Screening Contrast-enhanced Mammography
NCT05390229
Recruiting
The main objective of this study is to compare the diagnostic performance of two diagnostic methods, namely CESM and MRI, in the evaluation of a lesion suspicious of breast cancer in 300 Quebec women referred for the investigation of breast cancer. breast lesion suspected of cancer. All suspicious lesions will be evaluated by these two diagnostic imaging and by TNM. Then, radiologists will respectively interpret diagnostic imaging, without knowing the result of the other imaging in parallel with... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: St-Sacrement Hospital, Quebec City, Quebec
Conditions: Breast Cancer
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IL-13 Blockade and Airway Autoimmunity in Asthma
NCT05564078
Recruiting
It has been observed that certain section of patients having severe to moderate Asthma, do not benefit from oral corticosteroids and IL-5 blocking biologics. There is increasing evidence that Airway auto immunity may be responsible for this poor response to treatment. It has been seen in earlier study done at Nair lab that these patients might benefit from Dupilumab, a biologic blocking IL-13/ IL-4. IL-13/IL-4 are the cytokines responsible for increased inflammation in these Asthmatics. The hypo... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/12/2025
Locations: The Research Institute of St. Joe's Hamilton, Hamilton, Ontario
Conditions: Airway Auto Immunity in Asthma
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Safety and Efficacy of NMD670 in Ambulatory Adult Patients With Type 3 Spinal Muscular Atrophy
NCT05794139
Recruiting
The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of NMD670 in the treatment of ambulatory adults with spinal muscular atrophy type 3
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/12/2025
Locations: UCLA David Geffen School Of Medicine - Neurology, Los Angeles, California +28 locations
Conditions: Spinal Muscular Atrophy
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Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.
NCT06007495
Recruiting
The goal of this pilot randomized cross-over study is to compare the effect of a full-face mask with expiratory washout to a conventional full face mask on non-invasive ventilation (NIV) in patients with acute hypercapnic, and acute hypoxemic, respiratory failure. The main questions it aims to answer are: * Does a mask with expiratory washout improve minute ventilation in patients using non-invasive ventilation compared with a conventional single-limb NIV mask * How does a mask with expiratory... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec +1 locations
Conditions: Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure
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Partial Prostate Salvage High Dose Rate Brachytherapy
NCT03246802
Recruiting
A dose-response relationship for radiation in the management of prostate cancer is well established. Local recurrence of prostate cancer after external beam radiotherapy occurs in at least 40% of patients treated because of inability to deliver sufficient dose through external beam techniques. These patients respond well to re-irradiation using brachytherapy with about 50% of selected patients remaining free of recurrence 5 years after salvage. Advanced imaging using multiparametric Magnetic Res... Read More
Gender:
MALE
Ages:
45 years and above
Trial Updated:
03/11/2025
Locations: BCCA Center for the Southern Interior, Kelowna, British Columbia
Conditions: Recurrent Prostate Cancer
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The Sleep Course: an Online Sleep Intervention for Adults with Self-reported Sleep Difficulties
NCT06745349
Recruiting
This study evaluates an internet-delivered cognitive behavioural therapy for insomnia (ICBTi) intervention, known as the Sleep Course, within a routine online therapy clinic (the Online Therapy Unit). The Sleep Course will specifically be offered to clients with self-reported sleep difficulties (i.e., falling or staying asleep or waking early) and daytime distress and or impairment. This study aims to replicate the effectiveness and acceptability of the previously evaluated Sleep Course when del... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Online Therapy Unit, Regina, Saskatchewan
Conditions: Insomnia, Depression, Anxiety
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Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium
NCT04008563
Recruiting
A growing population of young women with obesity are developing atypical hyperplasia (pre-cancer) and endometrial cancer. Progestin is the standard treatment for women who wish to preserve fertility, but this approach does not address the underlying cause of endometrial cancer/atypical hyperplasia (obesity); thus response rates are low and recurrence rates are high. Significant weight loss by bariatric surgery, in combination with progestin therapy may result in greater and more durable response... Read More
Gender:
FEMALE
Ages:
Between 18 years and 41 years
Trial Updated:
03/11/2025
Locations: Princess Margaret Hospital, Toronto, Ontario
Conditions: Endometrial Cancer, Atypical Hyperplasia, Bariatric Surgery Candidate
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Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
NCT04278404
Recruiting
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Gender:
ALL
Ages:
Between 0 years and 20 years
Trial Updated:
03/11/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +50 locations
Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Hemophilia, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
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ED to EPI: Using SMS to Improve the Transition from the Emergency Department to Early Psychosis Intervention
NCT04298450
Recruiting
Psychosis is a disabling condition that typically has its onset in adolescence and early adulthood. Many young people with psychosis have difficulty navigating services or are reluctant to engage in treatment until their illness becomes an emergency. Consequently, nearly half of all new psychotic disorders are diagnosed in the emergency department (ED). Despite the rationale and evidence for early psychosis intervention (EPI), around half of youth do not access these services. The investigators... Read More
Gender:
ALL
Ages:
Between 16 years and 29 years
Trial Updated:
03/11/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: First Episode Psychosis, Psychosis, Psychotic Episode, Psychoses, Affective, Bipolar Disorder, Depressive Psychosis, Schizoaffective Disorder, Schizophreniform Disorders, Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Substance Induced Psychoses
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5500/20 Vs. SABR or Brachytherapy for PRimary OligoMetastatic Prostate Cancer Treatment (PROMPT)
NCT04610372
Recruiting
We will investigate whether ultrahypofractionation using stereotactic ablative radiotherapy (SABR) or brachytherapy is as well-tolerated as moderately hypofractionated external beam radiotherapy (EBRT) for treating the prostate in patients with oligometastatic prostate cancer. Secondary aims include assessment of progression-free survival (PFS) and overall survival (OS) as well as cost-effectiveness. We hypothesize that ultrahypofractionation will maintain favorable toxicity profiles and quality... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: British Columbia Cancer Agency Center for the Southern Interior, Kelowna, British Columbia +3 locations
Conditions: Oligometastatic Prostate Cancer
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Canada-wide Implementation of a Virtual Sexual Health and Rehabilitation eClinic (SHAReClinic) for Prostate Cancer Patients and Their Partners
NCT06877598
Recruiting
The goal of this observational study is to evaluate the effectiveness of SHAReClinic, a national, virtual Sexual Health and Rehabilitation eClinic designed to support prostate cancer patients and their partners. Specifically, this study aims to assess SHAReClinic's impact on improving sexual function, satisfaction, and relational intimacy after treatment. The primary objective is to evaluate SHAReClinic's effectiveness across participating sites and determine its role in supporting long-term se... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Vancouver Coastal Health Authority, Vancouver, British Columbia +9 locations
Conditions: Prostate Cancer, Sexual Dysfunction, Physiological, Sexual Dysfunction, Psychological, Sexual Dysfunction, Virtual Care, Virtual Clinic, Survivorship, Implementation of Evidence Based Programs, Implementation
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Feasibility of Early Swallowing and Speech Intervention for Head and Neck Cancer Patients Treated SURGically
NCT06192771
Recruiting
Oral cavity cancer (OCC) is one of the most common cancers worldwide, with tongue cancer being one of the most common subtypes. Patients with oral cancers can experience painful swallowing, swallowing difficulty (dysphagia), and associated weight loss long after surgery. Not only is dysphagia an independent predictor of quality of life (QoL) in cancer survivorship, it can also have a devastating impact on the health of patients resulting from complications such as pneumonia, malnutrition and fee... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: University Health Network, Toronto, Ontario
Conditions: Dysphagia, Head and Neck Cancer
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