Evaluating the Effect of Questionnaire Context on the Reporting of Somatic Items Among People with Systemic Sclerosis
NCT06772896
Recruiting
There is concern that self-reported depression questionnaires that contain items assessing somatic symptoms may result in biased scores in people with a chronic disease due to symptoms that overlap with their physical disease. However, it has been shown in previous studies that biases associated with somatic items do not affect total depression scores. The reason for this is still unclear but could be associated with the context in which these items are presented. The goal of this experiment is... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Jewish General Hospital, Montreal, Quebec +1 locations
Conditions: Scleroderma, Systemic Sclerosis (SSc), Scleroderma (limited and Diffuse)
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Stem Cell Study in Osteoarthritis of the Knee and Hip Joints
NCT05507099
Recruiting
The purpose of this trial is to compare the effect of a single intra-articular injection of Lipoaspirate Concentrate vs Bone Marrow Aspirate on pain reduction and functional improvement in the treatment of the knee and hip OA.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
03/03/2025
Locations: Karmy Clinic, Brampton, Ontario
Conditions: Osteoarthritis
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JoyPop Mobile Mental Health App with Indigenous Youth
NCT05898516
Recruiting
Indigenous youth in Northwestern Ontario who need mental health supports experience longer waits than non-Indigenous youth within the region and when compared to youth in other more urban areas. Limited access and extended waits can exacerbate symptoms, prolong distress, and increase risk for more serious outcomes. Novel, innovative approaches are urgently needed to provide support for Indigenous youth in Northwestern Ontario. In partnership with Dilico Anishinabek Family Care, the investigators... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
03/03/2025
Locations: Lakehead University, Thunder Bay, Ontario
Conditions: Emotion Regulation, Depression, Anxiety, Stress
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Investigating Genetic Status in Patients Presenting to Clinic
NCT05911932
Recruiting
The causes of neurodegenerative dementias such as Frontotemporal Dementia, Lewy Body Disease and Alzheimer's disease are still largely unknown. While the contribution of some genetic mutations and polymorphisms is associated with autosomal dominant patterns of inheritance of these dementias, in many cases, the specific causative mutation in these families is not yet identified. Further, in many patients, polygenic risk is thought to give rise to pathophysiologic changes, but which specific genes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Parkwood Institute, London, Ontario
Conditions: Dementia, Frontotemporal, Alzheimer Dementia (AD), Lewy Body Dementia (LBD)
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Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
NCT06142773
Recruiting
The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to the lungs via a breathing machine greater the brain activity and also the greater the injury to the brain cells. There is no study in humans that investigates the physiological communication between the volume of air delivered to the lungs and brain activity. This is imp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Toronto General Hospital, Toronto, Ontario
Conditions: Ventilation Therapy; Complications
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Biobeat Digital Home Monitoring Feasibility
NCT06417996
Recruiting
To assess the feasibility of evaluating postoperative home monitoring with Biobeat digital monitoring. The investigators hypothesize that the Biobeat digital home monitoring platform will lead to a decrease in unplanned visits to the ED (Emergency Department). In addition, patients' quality of life is postulated to be improved compared to patients receiving the current standard of care without home monitoring.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: London Health Sciences Centre, London, Ontario
Conditions: Thoracic Surgery, Home Monitoring
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SWiFT Canada (Study of Whole Blood in Frontline Trauma)
NCT06495294
Recruiting
Traumatic injuries affect people of all ages, races, and socioeconomic backgrounds. The Global Burden of Disease study showed that globally in 2019, there were more than 4.4 million deaths due to injury. Furthermore, unintentional injuries are the leading cause of death for people aged 5-29 years worldwide. Uncontrolled bleeding accounts for a significant proportion of these deaths, with approximately 20% occurring in the first 24 hours and 40% occurring within the first 30 days. Blood transfus... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
03/03/2025
Locations: Ornge Air Ambulance, Toronto, Ontario
Conditions: Trauma
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Cervical Plexus Hydrodissection With D5W for PTSD
NCT04421573
Recruiting
PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with PTSD. This randomized trial will compare dextrose injection with a delayed/usual treatment control.
Gender:
ALL
Ages:
Between 19 years and 90 years
Trial Updated:
03/01/2025
Locations: Hawaii Center for Regenerative Medicine, Hilo, Hawaii +6 locations
Conditions: PTSD
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Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618
Recruiting
The Primary Completion Date and Study Completion Date have been updated to reflect completion of the adolescent cohort, which has been added to the protocol. The study is designed as a multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy.
Gender:
ALL
Ages:
Between 12 years and 60 years
Trial Updated:
03/01/2025
Locations: Childrens Hospital Colorado, Aurora, Colorado +81 locations
Conditions: C3G
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Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
NCT02715284
Recruiting
This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. Dose escalation will be based on ascending weight-based dose levels (DLs... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: GSK Investigational Site, Birmingham, Alabama +129 locations
Conditions: Neoplasms
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Effects of Compression Stockings in Asthma Symptoms At Night
NCT03303586
Recruiting
Nocturnal worsening of asthma is common. It is characterized by overnight exacerbation of asthma symptoms such as shortness of breath, chest tightness, coughing, and wheezing, increased need of asthma medications and airway hyperresponsiveness, and decline in lung function (1). Nocturnal asthma has been attributed in part to circadian variations in lung function and airway inflammation. However, other factors including sleep, supine posture and lung volume may also contribute to nocturnal asthma... Read More
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
02/28/2025
Locations: Toronto Rehabilitation Institute (TRI), Toronto, Ontario
Conditions: Asthma
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Advanced Endo-therapeutic Procedure : Registry-based Observational Study
NCT04117100
Recruiting
Advanced therapeutic endoscopy procedures are of increasing importance to provide minimal invasive treatment for GI diseases. The Centre Hospitalier de l'Université de Montréal as tertiary university center is dedicated to increase the availability of therapeutic endoscopy procedures for our population in Montreal and Quebec. Advanced endotherapeutic endoscopy can replace surgery for treatment of benign and malign GI diseases and the aim of this registry-based study is to improve quality related... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: Centre Hospitalier Universitaire de Montréal (CHUM), Montréal, Quebec
Conditions: Zenker Diverticulum, Polyp of Colon, Colo-rectal Cancer
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