SWiFT Canada (Study of Whole Blood in Frontline Trauma)
NCT06495294
Recruiting
Traumatic injuries affect people of all ages, races, and socioeconomic backgrounds. The Global Burden of Disease study showed that globally in 2019, there were more than 4.4 million deaths due to injury. Furthermore, unintentional injuries are the leading cause of death for people aged 5-29 years worldwide. Uncontrolled bleeding accounts for a significant proportion of these deaths, with approximately 20% occurring in the first 24 hours and 40% occurring within the first 30 days. Blood transfus... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
03/03/2025
Locations: Ornge Air Ambulance, Toronto, Ontario
Conditions: Trauma
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Cervical Plexus Hydrodissection With D5W for PTSD
NCT04421573
Recruiting
PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with PTSD. This randomized trial will compare dextrose injection with a delayed/usual treatment control.
Gender:
ALL
Ages:
Between 19 years and 90 years
Trial Updated:
03/01/2025
Locations: Hawaii Center for Regenerative Medicine, Hilo, Hawaii +6 locations
Conditions: PTSD
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Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618
Recruiting
The Primary Completion Date and Study Completion Date have been updated to reflect completion of the adolescent cohort, which has been added to the protocol. The study is designed as a multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy.
Gender:
ALL
Ages:
Between 12 years and 60 years
Trial Updated:
03/01/2025
Locations: Childrens Hospital Colorado, Aurora, Colorado +81 locations
Conditions: C3G
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Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
NCT02715284
Recruiting
This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. Dose escalation will be based on ascending weight-based dose levels (DLs... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: GSK Investigational Site, Birmingham, Alabama +129 locations
Conditions: Neoplasms
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Effects of Compression Stockings in Asthma Symptoms At Night
NCT03303586
Recruiting
Nocturnal worsening of asthma is common. It is characterized by overnight exacerbation of asthma symptoms such as shortness of breath, chest tightness, coughing, and wheezing, increased need of asthma medications and airway hyperresponsiveness, and decline in lung function (1). Nocturnal asthma has been attributed in part to circadian variations in lung function and airway inflammation. However, other factors including sleep, supine posture and lung volume may also contribute to nocturnal asthma... Read More
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
02/28/2025
Locations: Toronto Rehabilitation Institute (TRI), Toronto, Ontario
Conditions: Asthma
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Advanced Endo-therapeutic Procedure : Registry-based Observational Study
NCT04117100
Recruiting
Advanced therapeutic endoscopy procedures are of increasing importance to provide minimal invasive treatment for GI diseases. The Centre Hospitalier de l'Université de Montréal as tertiary university center is dedicated to increase the availability of therapeutic endoscopy procedures for our population in Montreal and Quebec. Advanced endotherapeutic endoscopy can replace surgery for treatment of benign and malign GI diseases and the aim of this registry-based study is to improve quality related... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: Centre Hospitalier Universitaire de Montréal (CHUM), Montréal, Quebec
Conditions: Zenker Diverticulum, Polyp of Colon, Colo-rectal Cancer
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EMPower Mechanisms
NCT06861465
Recruiting
Primary Biliary Cholangitis (PBC) is a chronic liver disease that can cause fatigue, itching, brain fog, and emotional distress, all of which can lower quality of life. While the standard treatment, ursodeoxycholic acid (UDCA), helps slow the disease, it does not relieve these symptoms. Research shows that mind-body practices-such as breathing exercises, meditation, and gentle movement-can help improve mental and physical well-being in people with chronic conditions, but their benefits for PBC a... Read More
Gender:
FEMALE
Ages:
Between 40 years and 75 years
Trial Updated:
02/28/2025
Locations: University of Alberta, Edmonton, Alberta
Conditions: Primary Biliary Cholangitis (PBC)
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Artificial Intelligence (AI) Assisted Real-time Adenoma Detection and Classification During Colonoscopies
NCT05244278
Recruiting
This is a pragmatic, double-blind, randomized, controlled trial, to evaluate the effect of implementing a Computer-assisted detection (CADe) system within the routine clinical practice of Canadian healthcare institutions. The main hypothesis of this study is that the ADR in the operating room equipped with the GI genius CADe system will be significantly higher than the ADR in the ordinary operating room.
Gender:
ALL
Ages:
Between 45 years and 89 years
Trial Updated:
02/28/2025
Locations: Centre Hospitalier Universitaire de Montréal, Montréal, Quebec
Conditions: Artificial Intelligence
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Novel MRI Biomarkers for Monitoring Disease Progression in ALS
NCT03362658
Recruiting
Routine MRI is normal in motor neuron diseases such as ALS. However, advanced MRI techniques can provide an objective measure of degeneration (a "biomarker") by examining brain structure, wiring, chemistry, and function. We will develop and evaluate novel MRI techniques that could improve our understanding of ALS and provide a means to diagnose it sooner and monitor its progression. Importantly, we expect these techniques to improve how new drugs are tested, which may lead to the more rapid disc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2025
Locations: University of Miami, Miami, Florida +8 locations
Conditions: Amyotrophic Lateral Sclerosis, Motor Neuron Disease
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The Interplay Between Inborn Error of Immunity and Blood Disorders: Unravelling Immune Defects Behind Common Haematological Diseases
NCT06857604
Recruiting
The universe of Inborn errors of Immunity (IEI) is rapidly expanding: their clinical spectrum is not only characterised by infections but often includes haematological complications. Moreover, an increasing number of "IEI phenocopies" due to somatic mutations in specific cell types are progressively being unveiled and complicate the genetic plot of IEI, which are therefore not only caused by germline mutations. However, these aspects have never been studied by large prospective studies. This st... Read More
Gender:
ALL
Ages:
25 years and below
Trial Updated:
02/27/2025
Locations: CHU Sainte-Justine, Montreal, Not set +6 locations
Conditions: Hematologic Diseases
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A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants with ALS
NCT05279755
Recruiting
The primary purpose of this study is to evaluate the safety and tolerability of prosetin in healthy volunteers and participants with ALS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +3 locations
Conditions: Amyotrophic Lateral Sclerosis
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The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery
NCT06230198
Recruiting
The TheRAPy vanguard trial is a multicentre, multiple period randomized, cluster crossover vanguard trial testing the feasibility of a full-scale trial to evaluate whether a centre-based policy of routine use of RAP versus a policy of crystalloid priming reduces RBC transfusion for patients undergoing cardiac surgery on cardiopulmonary bypass. It will also provide information about key parameters of the TheRAPy full-scale trial.
Gender:
ALL
Ages:
Between 10 years and 110 years
Trial Updated:
02/27/2025
Locations: St. Boniface Hospital, Winnipeg, Manitoba +3 locations
Conditions: Red Blood Cell Transfusion
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