Clinical Trials & Research Studies in Canada(Updated 8/25)

A Study to Assess the Safety of ARGX-109 in Healthy Volunteers

NCT06799416

Recruiting

This study aims to assess the safety of ARGX-109 in healthy adults. Another aim is to measure the amount of ARGX-109 in the blood over time to learn how it moves through the body and acts in the body. Each participant will remain in the study for approximately 20 weeks.

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

01/23/2025

Locations: Altasciences - Montreal - Phase I unit, Mount-Royal, Quebec

Conditions: Healthy Volunteer

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Breakthrough CMV Lung Transplant -Multicentre

NCT04439916

Recruiting

Cytomegalovirus (CMV) infection is the most common opportunistic infection in lung transplantation leading to direct and indirect effects that can result in life threatening complications. The risk of CMV infection is highest when the recipient of the transplant has never been in contact with CMV (negative immunity) and the donor had previous contact with CMV (positive immunity). This is called CMV mismatch. For these lung transplant patients 6 to 12 months of prophylaxis with an antiviral calle... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/22/2025

Locations: University of Alberta Hospital, Edmonton, Alberta

Conditions: Cytomegalovirus Infections

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Pediatric Orthopaedic Implant Safety & Efficacy

NCT05361980

Recruiting

Implant devices are important tools - their use is essential across a number of orthopaedic indications, including hip conditions, trauma and limb deformity. Given the vital role fixation devices play in maintaining alignment, promoting healthy bone healing and preventing joint degeneration, it is essential to understand the expected lifetime outcomes of these implants, and evaluate their safety and efficacy. Prospective implant efficacy and safety registries are needed to support this endeavo... Read More

Gender:

ALL

Ages:

Between 0 years and 25 years

Trial Updated:

01/22/2025

Locations: BC Children's Hospital, Vancouver, British Columbia

Conditions: Fracture, Lengthening; Leg, Orthopedic Disorder, Deformity of Limb, Deformity; Bone, Implant Breakage, Implant Complication, Hip Dysplasia, Pediatric ALL, Hip Disease, Hip Dislocation

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CHARM-COPD Program of Care

NCT06253013

Recruiting

The investigators' goal for this project is to evaluate the feasibility, acceptability, and actual usage of a program of care for patients with COPD recently discharged after an acute exacerbation. The program of care includes virtual pulmonary rehabilitation, integrated care, and remote clinical monitoring.

Gender:

ALL

Ages:

40 years and above

Trial Updated:

01/22/2025

Locations: University Health Network, Toronto, Ontario

Conditions: Chronic Obstructive Pulmonary Disease

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Optimal Intensity of Reactive Balance Training Post-stroke

NCT06555016

Recruiting

Falls in daily life are a serious risk for people with stroke. A new type of balance training, called reactive balance training (RBT). may help to reduce this risk of falling. In some previous studies participants improved their balance reactions a lot after RBT, whereas others did not improve at all. These studies used different types and amounts of training. Differences in training program features might explain differences in the study results. Training intensity is the difficulty or challen... Read More

Falls in daily life are a serious risk for people with stroke. A new type of balance training, called reactive balance training (RBT). may help to reduce this risk of falling. In some previous studies participants improved their balance reactions a lot after RBT, whereas others did not improve at all. These studies used different types and amounts of training. Differences in training program features might explain differences in the study results. Training intensity is the difficulty or challenge of the training program. For other types of exercise (like 'cardio' or strength training) if the intensity of exercise is increased, someone can get the same benefits in less time than with lower intensity exercise. Physiotherapists report that they have limited time in rehabilitation to do everything they need to do with their stroke patients, so it would be valuable to know if high-intensity RBT improves balance reactions quickly. The goal of this study is to see if more intense RBT improves balance reactions faster than less intense RBT. People with chronic stroke will be randomly placed in one of three groups: high-intensity RBT, moderate-intensity RBT, or a walking control group. The investigators will find the fastest moving platform speed that participants can respond to with single step (multi-step threshold). There will then be 4 1-hour long training sessions in one week. Participants in the high-intensity group will experience platform movements that are 50% faster than the multi-step threshold. Participants in the moderate-intensity group will experience platform movements at the multi-step threshold. Participants in both RBT groups will experience 36 multi-directional platform movements in each training session, causing them to start to fall forwards, to the left, or to the right. Participants in the walking group will walk on the platform 36 times without any platform movements. The investigators will measure how quickly people improve their balance reactions over the training program. Read Less

Gender:

ALL

Ages:

20 years and above

Trial Updated:

01/22/2025

Locations: Toronto Rehabilitation Institute, Toronto, Ontario

Conditions: Accidental Fall, Stroke

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RSV Vaccine in Transplant Recipients

NCT06593210

Recruiting

Adjuvant, non-live RSV vaccine will be administered to adult lung and allogeneic hematopoietic stem cell transplant recipients. The safety and immunogenicity of this intervention will be studied. Blood work will be collected before and after the intervention, to assess humoral and cellular immunity. Participants will be followed for adverse reaction, hospitalization, RSV breakthrough infection, graft rejection or graft versus host disease. This study has Health Canada and UHN REB approval.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/22/2025

Locations: University Health Network, Toronto, Not set

Conditions: Vaccine Response Impaired, Respiratory Syncytial Virus Infections, Immune Suppression

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Optimal Intensity of Reactive Balance Training for Healthy Older Adults

NCT06657989

Recruiting

Falls in daily life are a serious risk for older adults. A new type of balance training, called reactive balance training (RBT) involves people losing balance many times so that they can practice fast balance reactions, like stepping reactions. Differences in training program features might explain differences in the results of previous RBT studies. Training intensity is the difficulty or challenge of the training program. It would be valuable to know if high-intensity RBT improves balance react... Read More

Gender:

ALL

Ages:

Between 65 years and 80 years

Trial Updated:

01/22/2025

Locations: University Health Network, Toronto, Ontario

Conditions: Accidental Falls

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Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs

NCT02493478

Recruiting

Advanced airway interventions are common high risk, high stakes events for children in intensive care units (ICU) and emergency departments (ED), with risk for life and health threatening consequences.

Gender:

ALL

Ages:

All

Trial Updated:

01/21/2025

Locations: Children's of Alabama at Birmingham, Birmingham, Alabama +86 locations

Children's of Alabama at Birmingham, Birmingham, Alabama

Phoenix Children's Hospital, Phoenix, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

Children's Hospital of Central California, Madera, California

University of Colorado Hospital, Aurora, Colorado

Yale New Haven Children's Hospital, New Haven, Connecticut

Yale-New Haven Children's Hospital, New Haven, Connecticut

Nemours Children's Health, Delaware, Wilmington, Delaware

Miami Children's Hospital, Miami, Florida

Emory University, Atlanta, Georgia

Children's Hospital of Atlanta - Scottish Rite, Atlanta, Georgia

Children's Hospital of Georgia, Augusta, Georgia

Northwestern Medicine Prentice Women's Hospital, Chicago, Illinois

Riley Hospital for Children, Indianapolis, Indiana

Beacon Children's Hospital, South Bend, Indiana

Kentucky Children's Hospital, Lexington, Kentucky

Norton Children's Hospital - University of Louisville, Louisville, Kentucky

Johns Hopkins Medicine, Baltimore, Maryland

University of Maryland, Baltimore, Maryland

Boston Children's Hospital, Boston, Massachusetts

Baystate Medical Center, Springfield, Massachusetts

Gillette Children's Specialty Health, Saint Paul, Minnesota

Children's Hospitals and Clinics of Minnesota, Saint Paul, Minnesota

Children's Hospital and Medical Center, Omaha, Nebraska

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

Morristown Medical Center, Morristown, New Jersey

Albany Medical College, Albany, New York

The Children's Hospital at Montefiore, Bronx, New York

Oishei Children's Hospital, Buffalo, New York

Cohen Children's Medical Center, New Hyde Park, New York

New York Presbyterian Hospital Weill Cornell Medical College, New York, New York

University of Rochester at Golisano Children's Hospital, Rochester, New York

Stony Brook Children's Hospital, Stony Brook, New York

Maria Fareri Children's Hospital (West Chester Medical), Valhalla, New York

Duke Children's Hospital, Durham, North Carolina

WakeMed Health & Hospitals, Raleigh, North Carolina

WakeMed, Raleigh, North Carolina

Akron Children's Hospital, Akron, Ohio

Cincinnati Hospital Medical Center, Cincinnati, Ohio

Cleveland Clinic Childrens Hospital, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Oregon Health and Science University, Portland, Oregon

Children's Hospital - Penn State Hershey, Hershey, Pennsylvania

Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Hasbro Children's Hospital, Providence, Rhode Island

Le Bonheur Children's Hospital, Memphis, Tennessee

Dell Children's Medical Center - Ascension, Austin, Texas

Medical City Children's Hospital, Dallas, Texas

Baylor - Christus Children's - Main Hospital, Irving, Texas

Baylor - Christus Children's - Westover Hills, San Antonio, Texas

Baylor - Christus Children's - Stone Oak, San Antonio, Texas

The University of Vermont Children's Hospital, Burlington, Vermont

UVA Children's Hospital, Charlottesville, Virginia

Children's Hospital of Richmond at VCU, Richmond, Virginia

Seattle Children's Hospital, Seattle, Washington

University of Washington Medical Center, Seattle, Washington

University of Wisconsin - UnityPoint Meriter, Madison, Wisconsin

American Family Children's Hospital - University of Wisconsin, Madison, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

University of Wisconsin - American Family Children's Hospital, Shorewood Hills, Wisconsin

Royal Brisbane and Women's Hospital, Herston, Not set

The Royal Children's Hospital Melbourne, Parkville, Not set

Medical University of Vienna (Medizinische Universität Wien), Vienna, Not set

Foothills Medical Centre, Calgary, Alberta

Alberta Children's Hospital, Calgary, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

CHU Sainte-Justine, Montreal, Quebec

CHU Sainte-Justine, Montréal, Quebec

The University of Manitoba, Winnipeg, Not set

University Hospital Schleswig-Holstein, Campus Luebeck, Children's Hospital, Luebeck, Not set

Aster Hospitals - India, Bengaluru, Karnataka

Rainbow Children's Hospital, Bangalore, Not set

Bambino Gesu, Roma, Not set

National Center for Child Health and Development, Setagaya-Ku, Tokyo

Hiroshima University, Hiroshima, Not set

Hyogo Prefectural Kobe Children's Hospital, Kobe, Not set

Aichi Children's Health and Medical Center, Obu, Not set

Saitama Children's Medical Center, Saitama, Not set

Jichi Medical University Hospital, Shimotsuke, Not set

Tokyo Metropolitan, Tokyo, Not set

Starship Children's Hospital, Auckland, Not set

KK Women's and Children's Hospital, Singapore, Not set

KK Women's & Children's Hospital, Singapore, Singapore, Not set

Cardiff & Vale University Health Board, Cardiff, Wales

Conditions: Failed or Difficult Intubation, Sequela, Intubation; Difficult, Intubation Complication

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Resistance Intensive Personal Training for Youth with Cerebral Palsy

NCT05731609

Recruiting

Changes related to Cerebral Palsy (CP) include differences in muscle architecture and cortical activity. These result in weakness, decreased functional ability and limited participation in physical activity. Strength training programs, particularly those including power training components, show great potential in improving the gross motor function of youth with CP. However, this intervention is not currently offered in the Calgary area. Delivered via an innovative partnership with community sta... Read More

Gender:

ALL

Ages:

Between 8 years and 17 years

Trial Updated:

01/21/2025

Locations: Alberta Children's Hospital, Calgary, Alberta

Conditions: Cerebral Palsy, Exercise, Resistance Training

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Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma

NCT05734066

Recruiting

This study is conducted in two phases. The phase 1 portion of the study evaluates the safety, tolerability, pharmacokinetics (PK), recommended phase 2 dose (RP2D), and effectiveness of lurbinectedin monotherapy in pediatric participants with previously treated solid tumors. This is followed by the phase 2 portion, to further assess the effectiveness and safety in pediatric and young adult participants with recurrent/refractory Ewing sarcoma.

Gender:

ALL

Ages:

Between 2 years and 30 years

Trial Updated:

01/21/2025

Locations: Children's Hospital Los Angeles, Los Angeles, California +14 locations

Conditions: Refractory Ewing Sarcoma, Relapsed Ewing Sarcoma, Ewing Sarcoma

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Longitudinal Prospective Natural History Study of Retinopathy in Zellweger Spectrum Disorder

NCT06190626

Recruiting

The goal of this observational study is to define the course of the retinal degeneration in a ZSD patient cohort. The objective of this study is to gather information so the investigators can: 1. define the course of the retinal degeneration in a ZSD patient cohort with retinal degeneration 2. define what tests best monitor the progression of the retinal degeneration 3. generate prognostic information about vision loss in ZSD. At each yearly visit, the participants will answer a functional vi... Read More

Gender:

ALL

Ages:

All

Trial Updated:

01/21/2025

Locations: University of Rochester Medical Center/Flaum Eye Institute, Rochester, New York +1 locations

Conditions: Zellweger Spectrum Disorder

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CHemotherapy and Stool Transplant in PDAC (CHASe-PDAC)

NCT06393400

Recruiting

To confirm the safety of combining oral fecal microbiota transplantation (FMT) with gemcitabine and nab-paclitaxel chemotherapy as first line treatment in patients with unresectable or metastatic pancreatic ductal adenocarcinoma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/21/2025

Locations: Verspeeten Family Cancer Centre (formerly known as the London Regional Cancer Program) London Health Sciences Centre, London, Ontario

Conditions: Unresectable or Metastatic Advanced Pancreatic Ductal Adenocarcinoma

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