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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
2305 - 2316 of 3904
Longitudinal Prospective Natural History Study of Retinopathy in Zellweger Spectrum Disorder
Recruiting
The goal of this observational study is to define the course of the retinal degeneration in a ZSD patient cohort.
The objective of this study is to gather information so the investigators can:
1. define the course of the retinal degeneration in a ZSD patient cohort with retinal degeneration
2. define what tests best monitor the progression of the retinal degeneration
3. generate prognostic information about vision loss in ZSD.
At each yearly visit, the participants will answer a functional vi... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/21/2025
Locations: University of Rochester Medical Center/Flaum Eye Institute, Rochester, New York +1 locations
Conditions: Zellweger Spectrum Disorder
CHemotherapy and Stool Transplant in PDAC (CHASe-PDAC)
Recruiting
To confirm the safety of combining oral fecal microbiota transplantation (FMT) with gemcitabine and nab-paclitaxel chemotherapy as first line treatment in patients with unresectable or metastatic pancreatic ductal adenocarcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/21/2025
Locations: Verspeeten Family Cancer Centre (formerly known as the London Regional Cancer Program) London Health Sciences Centre, London, Ontario
Conditions: Unresectable or Metastatic Advanced Pancreatic Ductal Adenocarcinoma
Assessing the Impact of DAy Programs on Individuals Living with Dementia and Their Family/friend Caregivers
Recruiting
This study seeks to understand the effects of adult day programs on older adults, especially those with dementia, and their caregivers. A prospective cohort study will be conducted in the Canadian provinces of Alberta, British Columbia, Manitoba, and Ontario. Participants will be (1) older adults with dementia who attend a day program, and their caregivers, and (2) older adults with dementia in the community who do not attend a day program, and their caregivers. The objectives are to (1) evaluat... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
01/21/2025
Locations: Edmonton and Calgary Health Zones, Edmonton & Calgary, Alberta +3 locations
Conditions: Adult Day Programs, Continuing Care, Old Age; Dementia, Family/Friend Caregivers
ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression
Recruiting
To determine if an high intensity ketamine with ECT rescue (HIKER) approach for treatment resistant depression will: 1) reduce patient suffering by hastening disease remission, 2) have fewer side effects, 3) reduce the need for ECT, and 4) be preferred by most patients. Half of participants will be randomized to the HIKER arm and receive high intensity ketamine treatment for eight consecutive days, and the other half will be assigned to the ECT with ketamine anesthesia (EAST) arm and receive 8 E... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Royal University Hospital, Saskatoon, Saskatchewan
Conditions: Treatment Resistant Depression, Ketamine
DIFFIR - Geriatric Distal Femur Fixation Versus Replacement
Recruiting
The current standard of care for most intra-articular distal femur fractures (above the knee joint) in geriatric patients is a surgical fixation using plates and screws to hold the fracture pieces in the correct position, until the fracture as healed.
However, surgical fixation of these complex fractures in geriatric patients, is associated with significant complications, such as non-union (when the broken bone does not heal properly), infection and the need for revision surgery. Additionally,... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
01/20/2025
Locations: St Michael's Hospital - Unity Health Toronto, Toronto, Ontario
Conditions: Distal Femur Fracture
Safety, Tolerability and Efficacy of Nefopam Cream in Burn Patients
Recruiting
Burn patients very commonly develop abnormal scars after injury which can be red, raised or elevated, painful and very itchy. They can prevent normal movement of hands and other joints and lead to ugly deformities which makes physical and psychological recovery very difficult. This proposal seeks to test the usefulness of a cream called Nefopam to prevent and treat these bad scars after burns and other injury to the skin. Nefopam is a drug that has been used as a pain medicine in Europe but has... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2025
Locations: University of Alberta Hospital, Edmonton, Alberta
Conditions: Burn; Multiple Body Regions, Max. Second Degree, Third-Degree Burn, Burn Degree Second
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
Recruiting
The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST v 1.1\]) after completing at least 12 weeks of platinum-based therapy. A total of 220 participants will be enrolled in the study and randomized in a 1:1 ratio to maintenance therapy with either selinexor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: The University of Alabama at Birmingham, Birmingham, Alabama +206 locations
Conditions: Endometrial Cancer
PDIFFIR: Geriatric Periprosthetic DIstal Femur: FIxation Versus Replacement
Recruiting
Periprosthetic distal femur fractures are a significant source of morbidity and mortality for elderly patients. One treatment option involved a surgical fixation with plates or nails, screws and cables/wires along the side of your fractured bone. The second method consists in replacing your knee joint with an artificial knee prosthesis (artificial knee joint).
The primary objective is to determine if acute distal femur replacement improves knee pain and functional outcomes compared to surgical... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
01/20/2025
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee, Knee Fracture
Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome
Recruiting
Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin resistance, endothelial dysfunction, and elevated blood pressure. Accordingly, PCOS is associated with the development of CVD, the second leading cause of death in females in Canada. However, effective treatments to improve cardiovascular health in PCOS are lacking.
Exogenous ket... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
01/20/2025
Locations: Cardiovascular Health and Autonomic Research Laboratory, Montréal, Quebec
Conditions: PCOS
Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
Recruiting
The goal of this study is to compare 2 medications that are commonly used to prevent excess uterine bleeding (postpartum hemorrhage, or PPH) following cesarean delivery (CD), oxytocin and carbetocin. Most of the trials evaluating the preventative role of oxytocin and carbetocin after CD have focused on patient with low-risk of PPH.
This trial will focus on patients that are at increased risk of PPH, with risk factors such as: multiple gestation (twins, or more multiples), large baby, polyhydram... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
01/20/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Post Partum Hemorrhage
1:1 and Group-based Exercise Intervention for Post-secondary Student Mental Health and Well-being
Recruiting
Post-secondary students report alarming rates of feeling overwhelmed, hopeless, anxious, and depressed. To better support student mental health, there is a well-documented need to improve the range and quality of mental health services available to students. Focussing on formalized treatment approaches and strategies supporting well-being in the campus community more generally are needed. Physical activity is an alternative therapeutic approach that could be implemented as an evidence-based life... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/20/2025
Locations: University of Toronto, Mental Health and Physical Activity Research Centre, Toronto, Ontario
Conditions: Physical Activity, Mental Health Issue
The Patient AS EDUcator in Anesthesia: Exploring the Patients' Experience During and After Unexpected Cesarean Delivery Under Neuraxial Anesthesia to Inform Anesthetic Practice
Recruiting
This study aims to explore the patients' and providers' perspectives and inform future anesthetic practice for patients undergoing unexpected cesarean delivery (CD) under neuraxial anesthesia (NA). The consideration of patients' concerns, preferences, expectations, and suggestions may lead to enhanced patient satisfaction, compliance, and quality of care that future patients receive during unexpected CD under NA. The investigators will possibly be able to identify gaps in procedural performance... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
01/20/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Psychological Well Being
2305 - 2316 of 3904
