All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Safety, Tolerability and Efficacy of Nefopam Cream in Burn Patients

NCT04685577

Recruiting

Burn patients very commonly develop abnormal scars after injury which can be red, raised or elevated, painful and very itchy. They can prevent normal movement of hands and other joints and lead to ugly deformities which makes physical and psychological recovery very difficult. This proposal seeks to test the usefulness of a cream called Nefopam to prevent and treat these bad scars after burns and other injury to the skin. Nefopam is a drug that has been used as a pain medicine in Europe but has been found to have anti-scarring properties in rats and pigs. It has been tested in healthy people and found to be well tolerated and safe. The study purposes to make a scratch in the hip skin in 60 adult burn patients at two burn unit sites, the University of Alberta and the University of California at Davis, Sacramento CA. Burn patients in the study will have a scratch wound in the skin of the each side of the hip, part way through the thickness of the skin which is shallow at first but gets deeper. This scratch is made with a special guide which precisely controls the length and depth of the scratch so that each scratch is the same. Part of the scratch heals without scar and the deeper part heals with a red raised scar over a small region less than 2 inches long. One side will be treated with the drug and the other with a control or placebo are in a white cream that is indistinguishable, where you cannot tell which side contains the drug. Once the wound is nearly healed, usually less than 21 days, the cream will be applied twice daily for three weeks. Measurements will be done about once per month for four months where the healing scratches will be photographed, measurements of the thickness made with ultrasound and mexameter for scar color or pigment and redness. Ultrasound is a painless probe that uses sound waves to measure scar thickness and mexameter is a painless probe on the surface of the scratch to measure color and redness. Both measurements take only minutes to complete. Patients will be asked to answer a scar assessment form about on how they feel each scratch during the treatment and the research staff will also the complete scar form as well. It is the aim of the study to find a cream the works to prevent and reduce scarring after burn injury in military or civilian patients. In the future, an useful cream for scarring in burn patients may also be helpful for other skin damage which leads to scarring. Read Less

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

01/20/2025

Locations: University of Alberta Hospital, Edmonton, Alberta

Conditions: Burn; Multiple Body Regions, Max. Second Degree, Third-Degree Burn, Burn Degree Second

Learn More ›

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

NCT05611931

Recruiting

The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST v 1.1\]) after completing at least 12 weeks of platinum-based therapy. A total of 220 participants will be enrolled in the study and randomized in a 1:1 ratio to maintenance therapy with either selinexor... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/20/2025

Locations: The University of Alabama at Birmingham, Birmingham, Alabama +206 locations

The University of Alabama at Birmingham, Birmingham, Alabama

Honor Health, Phoenix, Arizona

University of Arkansas for Medical Sciences, Little Rock, Arkansas

City of Hope National Medical Center, Duarte, California

Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California

City of Hope at Irvine Lennar, Irvine, California

Cancer and Blood Specialty Clinic, Los Alamitos, California

UCLA - Women's Health Clinical Research Unit, Los Angeles, California

Long Beach Memorial Medical Center, Los Angeles, California

UC Irvine, Orange, California

Stanford University, Palo Alto, California

California Pacific Medical Center, San Francisco, California

Highlands Ranch Hospital, Highlands Ranch, Colorado

University of Colorado Cancer Center, Highlands Ranch, Colorado

Broward Health Medical Center, Fort Lauderdale, Florida

Jupiter Medical Center, Jupiter, Florida

Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida

Advent Health, Orlando, Florida

Grady Hospital, Atlanta, Georgia

Emory University, Atlanta, Georgia

Georgia Cancer Center at Augusta University, Augusta, Georgia

Northeast Georgia Medical Center, Gainesville, Georgia

Illinois Cancer Specialists, Arlington Heights, Illinois

NorthShore University Health System, Evanston, Illinois

Northwest Cancer Center, Dyer, Indiana

Goshen Health, Goshen, Indiana

St Vincent Hospital, Indianapolis, Indiana

Memorial Hospital of South Bend, South Bend, Indiana

University of Iowa, Iowa City, Iowa

Our Lady of the Lake Hospital, Inc., Baton Rouge, Louisiana

LSU Health Sciences Center New Orleans, New Orleans, Louisiana

Trials365, LLC, Shreveport, Louisiana

Maine Medical Center, Scarborough, Maine

Tufts Medical Center, Boston, Massachusetts

Karmanos Cancer Institute, Detroit, Michigan

USON - Minnesota Oncology Hematology, Minneapolis, Minnesota

University of Minnesota, Minneapolis, Minnesota

St. Dominic's Gynecologic Oncology, Jackson, Mississippi

Midwest Ventures Group HCA MId America Division, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Women's Cancer Center of Nevada, Las Vegas, Nevada

Center Of Hope, Reno, Nevada

Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, New Jersey

Women's Cancer Care Associates, LLC, Albany, New York

NYU Langone Hospital-Long Island, Mineola, New York

Mount Sinai Chelsea, New York, New York

Perlmutter Cancer Center at NYU Langone Health, New York, New York

Mount Sinai, New York, New York

University of Rochester, Rochester, New York

Atrium Health Levine Cancer Institute, Charlotte, North Carolina

Duke Cancer Center, Durham, North Carolina

University of Cincinnati Medical Center, Cincinnati, Ohio

MetroHealth, Cleveland, Ohio

Zangmeister Cancer Center, Columbus, Ohio

ProMedica Flower Hospital, Sylvania, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Oklahoma Cancer Specialists and Research Institute, LLC, Tulsa, Oklahoma

Oncology Associates of Oregon, Eugene, Oregon

Providence Portland Medical Center, Portland, Oregon

Alliance Cancer Specialists, Langhorne, Pennsylvania

Magee - Women's Hospital, Pittsburgh, Pennsylvania

Allegheny Health Network - West Penn Hospital, Pittsburgh, Pennsylvania

Avera, Sioux Falls, South Dakota

Chattanooga's Program in Women's Oncology, Chattanooga, Tennessee

The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee

University of Tennessee Medical Center, Knoxville, Tennessee

University of Tennessee Health Science Center, Memphis, Tennessee

USON - Texas Oncology, Austin Central, Austin, Texas

Parkland Health & Hospital System, Dallas, Texas

Texas Oncology - Dallas, Dallas, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

Texas Oncology - Fort Worth, Fort Worth, Texas

Houston Methodist, Houston, Texas

Texas Oncology - San Antonio, San Antonio, Texas

Texas Oncology - The Woodlands, The Woodlands, Texas

Texas Oncology, PC, Tyler, Tyler, Texas

University of Utah, Salt Lake City, Utah

University of Virginia, Charlottesville, Virginia

University of Wisconsin Hospital and Clinics, Madison, Wisconsin

Medical College of Wisconsin/ Freodtert Hospital, Milwaukee, Wisconsin

Border Medical Oncology and Haematology, Albury East, New South Wales

Macarthur Cancer Therapy Centre, Campbell Town, New South Wales

Chris O'Brien Lifehouse, Camperdown, New South Wales

Central Coast LHD - Gosford & Wyong Hospitals, Gosford, New South Wales

Newcastle Private Hospital, New Lambton Heights, New South Wales

Royal North Shore Hospital, Saint Leonards, New South Wales

Westmead Hospital, Wentworthville, New South Wales

ICON Cancer Centre Southport, Southport, Queensland

Toowoomba Hospital, Toowoomba, Queensland

Royal Hobart Hospital, Hobart, Tasmania

Box Hill Hospital - Eastern Health (Oncology), Box Hill, Victoria

Monash Health, Clayton, Victoria

Frankston Hospital, Frankston, Victoria

Cabrini Health, Malvern, Victoria

Peter MacCallum Cancer Centre/RWH/RMH, Melbourne, Victoria

The Royal Adelaide Hospital, Southport, Not set

Cliniques Universitaires St. Luc, Bruxelles, Not set

AZ Sint Lucas, Gent, Not set

UZ Leuven, Leuven, Not set

CHU Ambroise Pare, Mons, Not set

CHU UCL Namur, Site Sainte-Elisabeth, Namur, Not set

Tom Baker Cancer Centre, Calgary, Alberta

Cross Cancer Institute, Edmonton, Alberta

Nova Scotia Health / QEII Health Sciences Centre / Atlantic Clinical Cancer Research Unit, Halifax, Nova Scotia

Princess Margaret, Toronto, Ontario

Sunnybrook Research Institute, Toronto, Ontario

Centre Hospitalier de l'Université de Montréal, Montreal, Quebec

Hospital Maisonneuve-Rosemont, Montreal, Quebec

McGill University Health Centre (MUHC), Montréal, Quebec

University Hospital Brno, Brno, Not set

University Hospital Ostrava, Ostrava, Not set

UH Královské Vinohrady, Prague, Not set

General University Hospital in Prague, Prague, Not set

Hospital Na Bulovce, Prague, Not set

High Technology Hospital Medcenter, Batumi, Not set

Todua Clinic, Tbilisi, Not set

LTD New Hospitals, Tbilisi, Not set

Tbilisi Cancer Center, Tbilisi, Not set

JSC - K.Eristavi National Center of Experimental and Clinical Surgery, Tbilisi, Not set

Caucasus Medical Centre, Tbilisi, Not set

LTD Innova Medical Center, Tbilisi, Not set

Multiprofile Clinic "Consilium Medulla", Tbilisi, Not set

Charite Berlin Universitatsmedizin, Berlin, Not set

Universitätsklinikum Hamburg Eppendorf, Hamburg, Not set

University Hospital Dresden, Kiel, Not set

Universitatsklinikum Schleswig-Holstein, Kiel, Not set

Helios Klinikum Krefeld, Krefeld, Not set

Universitätsklinik Leipzig, Liepzig, Not set

Universitätsfrauenklinik Mainz, Mainz, Not set

Universitätsmedizin Mannheim, Mannheim, Not set

Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe GroBhadern, Munich, Not set

Klinikum Südstadt Rostock, Rostock, Not set

Universitätsfrauenklinik Ulm, Ulm, Not set

IASO Hospital, Maroúsi, Athens

ALEXANDRA Hospital, Athens, Not set

Hygeia Hospital, Athens, Not set

Euromedica General Clinic, Thessaloníki, Not set

Unit of Gynecol.Oncol., Dept.Obstet.Gynecol., Clinical Center, University of Debrecen, Debrecen, Not set

Petz Aladár University Teaching Hospital, Győr, Not set

Cork University Hospital, Cork, Not set

St. James Hospital, Dublin, Not set

Galway University, Galway, Not set

University Hospital Waterford, Waterford, Not set

Hillel-Yaffe Medical Center, Hadera, Not set

Wolfson Medical Center, Holon, Not set

Hadassah Medical Center, Jerusalem, Not set

Sheba Medical Center, Ramat Gan, Not set

IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Not set

ASST Spedali Civili Di Brescia, Brescia, Not set

IRCCS Istituto Romagnolo Per Lo Studio Del Tumori "Dino Amadori" - IRST S.R.L., Meldola, Not set

Istituto Nazionale dei Tumori IRCCS - MILANO S. C. Ginecologia Oncologica, Milano, Not set

Instituto Europeo di Oncologia, Milano, Not set

Humanitas San Pio X Hospital, Milano, Not set

San Raffaele Hospital, Milan, Not set

Ospedale San Gerardo - Asst Monza, Monza, Not set

"Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" - NAPOLI Struttura Complessa Oncologia Medica Uro-Ginecologica", Napoli, Not set

Istituto Oncologico Veneto, Padova, Not set

Universita di Pisa, Pisa, Not set

Nuovo Ospedale di Prato, Prato, Not set

Fondazione Policlinico Universitario Agostino Gemelli - ROMA, Roma, Not set

Ospedale Ostetrico Ginecologico Sant'Anna, Torino, Not set

AO Ordine Mauriziano, Torino, Not set

Samsung Changwon Hospital, Changwon-si, Not set

Soon Chun Hyang University Hospital Cheonan, Cheonan-si, Not set

National Cancer Center (NCC), Goyang-si, Not set

Severance Hospital (Yonsei University Health System), Seongbuk-gu, Not set

CHA University/Bundang CHA General Hospital, Seongnam-si, Not set

Seoul National University Hospital, Seoul, Not set

Gangnam Severance Hospital, Seoul, Not set

Seoul St. Mary's Hospital, Seoul, Not set

Seoul National University Bundang Hospital, Seoul, Not set

Korea University Anam Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Asan Medical Center, Seoul, Not set

St. Elisabeth Cancer Institute, Bratislava, Not set

UH Bratislava, Bratislava, Not set

National Cancer Institute, Bratislava, Not set

UH Trenčín, Trenčín, Not set

ICO Badalona, Badalona, Not set

Hospital Universitari Vall d' Hebrón, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Institut Catala d'Oncologia Hospitalet, Barcelona, Not set

Hospital Universitario Reina Sofía, Córdoba, Not set

Virgen de la Arrixaca University Clinical Hospital, El Palmar Murcia, Not set

Hospital Universitario Donostia, Gipuzkoa, Not set

Institut Catala d'Oncologia de Girona, Girona, Not set

Hospital Universitario Virgen de las Nieves, Granada, Not set

MD Anderson Cancer Center Madrid, Madrid, Not set

Hospital Universitario Ramón y Cajal, Madrid, Not set

Hospital Universitario Clinico San Carlos, Madrid, Not set

H 12 de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitatrio Virgen de la Victoria, Málaga, Not set

Hospital Universitario Virgen del Rocío, Sevilla, Not set

Instituto Valenciano de Oncología, Valencia, Not set

Hospital Clínico Universitario de Valencia, Valencia, Not set

Hospital LaFe Uacenlia, Valencia, Not set

Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set

Hospital Miguel Servet, Zaragoza, Not set

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Not set

TaiChung Veterans General Hospital, Taichung, Not set

Chi Mei Medical Center, Tainan, Not set

Taipei Veterans General Hospital, Taipei City, Not set

Mackay Memorial Hospital, Taipei, Not set

Taipei Medical University- Shuang Ho Hospital, Ministry of Health and Welfare, Taipei, Not set

Chang Gung Memorial Hospital, Taoyuan City, Not set

Adana Baskent Hospital, Adana, Not set

Conditions: Endometrial Cancer

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PDIFFIR: Geriatric Periprosthetic DIstal Femur: FIxation Versus Replacement

NCT05805774

Recruiting

Periprosthetic distal femur fractures are a significant source of morbidity and mortality for elderly patients. One treatment option involved a surgical fixation with plates or nails, screws and cables/wires along the side of your fractured bone. The second method consists in replacing your knee joint with an artificial knee prosthesis (artificial knee joint). The primary objective is to determine if acute distal femur replacement improves knee pain and functional outcomes compared to surgical... Read More

Gender:

ALL

Ages:

65 years and above

Trial Updated:

01/20/2025

Locations: St. Michael's Hospital, Toronto, Ontario

Conditions: Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee, Knee Fracture

Learn More ›

Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome

NCT06155708

Recruiting

Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin resistance, endothelial dysfunction, and elevated blood pressure. Accordingly, PCOS is associated with the development of CVD, the second leading cause of death in females in Canada. However, effective treatments to improve cardiovascular health in PCOS are lacking. Exogenous ket... Read More

Gender:

ALL

Ages:

Between 18 years and 40 years

Trial Updated:

01/20/2025

Locations: Cardiovascular Health and Autonomic Research Laboratory, Montréal, Quebec

Conditions: PCOS

Learn More ›

Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery

NCT06333340

Recruiting

The goal of this study is to compare 2 medications that are commonly used to prevent excess uterine bleeding (postpartum hemorrhage, or PPH) following cesarean delivery (CD), oxytocin and carbetocin. Most of the trials evaluating the preventative role of oxytocin and carbetocin after CD have focused on patient with low-risk of PPH. This trial will focus on patients that are at increased risk of PPH, with risk factors such as: multiple gestation (twins, or more multiples), large baby, polyhydram... Read More

Gender:

FEMALE

Ages:

Between 18 years and 50 years

Trial Updated:

01/20/2025

Locations: Mount Sinai Hospital, Toronto, Ontario

Conditions: Post Partum Hemorrhage

Learn More ›

1:1 and Group-based Exercise Intervention for Post-secondary Student Mental Health and Well-being

NCT06350877

Recruiting

Post-secondary students report alarming rates of feeling overwhelmed, hopeless, anxious, and depressed. To better support student mental health, there is a well-documented need to improve the range and quality of mental health services available to students. Focussing on formalized treatment approaches and strategies supporting well-being in the campus community more generally are needed. Physical activity is an alternative therapeutic approach that could be implemented as an evidence-based lifestyle intervention for supporting mental health and well-being on post-secondary campuses. Despite the growing evidence supporting physical activity for student mental health, there are significant knowledge gaps in the literature. First, there is a paucity of research exploring the effects of different delivery styles (i.e., one-on-one (1:1) vs. group) on primary (i.e., mental health symptomology including anxiety symptoms, depression symptoms, psychological distress) and secondary (i.e., social support, social connectedness) outcomes. Secondly, the maintenance effects of a physical activity program on mental health or sustained physical activity behaviour change are largely unknown. Lastly, limited research has explored contextual implementation factors (e.g., intervention reach, adherence, and program satisfaction) that may influence the sustainability and scale-up of physical activity programs for student mental health. Examining contextual implementation factors is critical for optimizing physical activity intervention delivery and for facilitating wider dissemination of research findings into practice. The goal of this 3-arm parallel randomized controlled trial is to test the effectiveness of 1:1 physical activity intervention and group-based physical activity intervention compared to a wait-list control group in supporting post-secondary student mental health. The main questions include: * Are there group differences between 1:1, group-based delivery, and waitlist control in the immediate (post-intervention) and follow-up (1-month) maintenance effects on the primary and secondary outcomes? * Grounded in recommendations for process evaluation of complex interventions, what are contextual implementation factors that may be linked to variation in primary and secondary outcomes while offering insight for wider dissemination? Trial participants will be randomly assigned to one of the following groups: 1. 1:1 physical activity training; 2. Group-based physical activity training consisting of small 5-8 person groups; or 3. Waitlist control. Students will participate in the physical activity intervention after the intervention and follow-up period (10 weeks); however, their participation will not be monitored or evaluated. The physical activity training will involve a 6-week physical activity intervention consisting of weekly 1-hour sessions. Each session involves: (1) 30-minutes of behaviour change coaching (e.g., goal setting, action-planning, brainstorming strategies to overcome barriers to engaging in physical activity); and (2) 30-minutes of supervised and structured physical activity training. To address the aims of the study, participants will complete self-report questionnaires at baseline, post-intervention (following completion of the 6-week physical activity intervention), and 1-month following completion of the physical activity intervention. Questionnaires will assess demographic characteristics, primary outcomes (i.e., mental health symptomology including anxiety symptoms, depression symptoms, psychological distress), secondary outcomes (i.e., social support, social connectedness, physical activity behaviour) and contextual implementation factors (e.g., intervention reach, adherence, and program satisfaction) that may be linked to variation in primary and secondary outcomes while offering insight for wider dissemination. It is hypothesized that there will be no group differences between 1:1 delivery and group-based delivery on the primary outcomes. It is also hypothesized that group-based delivery, in comparison to 1:1 delivery will achieve greater improvements and more favourable maintenance effects in the secondary outcomes. Lastly, it is hypothesized that in comparison to the control group, 1:1 delivery and group-based delivery will be more effective in achieving change in the primary and secondary outcomes. Read Less

Gender:

ALL

Ages:

All

Trial Updated:

01/20/2025

Locations: University of Toronto, Mental Health and Physical Activity Research Centre, Toronto, Ontario

Conditions: Physical Activity, Mental Health Issue

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The Patient AS EDUcator in Anesthesia: Exploring the Patients' Experience During and After Unexpected Cesarean Delivery Under Neuraxial Anesthesia to Inform Anesthetic Practice

NCT06589687

Recruiting

This study aims to explore the patients' and providers' perspectives and inform future anesthetic practice for patients undergoing unexpected cesarean delivery (CD) under neuraxial anesthesia (NA). The consideration of patients' concerns, preferences, expectations, and suggestions may lead to enhanced patient satisfaction, compliance, and quality of care that future patients receive during unexpected CD under NA. The investigators will possibly be able to identify gaps in procedural performance... Read More

Gender:

FEMALE

Ages:

Between 18 years and 50 years

Trial Updated:

01/20/2025

Locations: Mount Sinai Hospital, Toronto, Ontario

Conditions: Psychological Well Being

Learn More ›

Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

NCT06735378

Recruiting

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

Gender:

ALL

Ages:

Between 18 years and 79 years

Trial Updated:

01/20/2025

Locations: London Health Sciences Centre, London, Ontario

Conditions: Hemodialysis, Cardioprotection

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Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients

NCT04608357

Recruiting

The investigators propose to use clinically validated patient avatar technology ("PDXovo") that can test multiple drugs against patients' cancers to identify the most promising systemic therapy for each individual.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/17/2025

Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario

Conditions: Breast Cancer, Breast Neoplasms, Metastatic Breast Cancer, Cancer, Breast

Learn More ›

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

NCT04779320

Recruiting

Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedolizumab. The main aim of the study is to check if participants achieve remission after treatment with the vedolizumab. Remission means symptoms improve or disappear and an endoscopy shows no signs of inflammation. Participants will receive 3 infusions of vedolizumab over 6 weeks. Then, those who have... Read More

Gender:

ALL

Ages:

Between 2 years and 17 years

Trial Updated:

01/17/2025

Locations: Phoenix Childrens Hospital, Phoenix, Arizona +95 locations

Phoenix Childrens Hospital, Phoenix, Arizona

Cedars Sinai Medical Center, Los Angeles, California

Rady Childrens Hospital San Diego - PIN, San Diego, California

University of California San Francisco, San Francisco, California

I.H.S Health LLC, Kissimmee, Florida

Childrens Center For Digestive Healthcare, Atlanta, Georgia

Advocate Children's Hospital Park Ridge, Park Ridge, Illinois

Riley Hospital For Children, Indianapolis, Indiana

Johns Hopkins University, Baltimore, Maryland

Boston Children's Hospital, Boston, Massachusetts

MNGI Digestive Health, PA, Minneapolis, Minnesota

Mayo Clinic - PIN, Rochester, Minnesota

Goryeb Children's Hospital, Morristown, New Jersey

The Steven and Alexandra Cohen Childrens Medical Center of New York - BRANY - PPDS, New Hyde Park, New York

University of Rochester Medical Center PPDS, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

SUNY Upstate Medical Center, Syracuse, New York

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Hasbro Children's Hospital, Providence, Rhode Island

Texas Children's Hospital, Houston, Texas

Carilion Children's Tanglewood Center, Roanoke, Virginia

Children's Hospital at Westmead, Westmead, New South Wales

Queensland Childrens Hospital, South Brisbane, Queensland

Monash Health, Monash Medical Centre, Clayton, Victoria

Royal Children's Hospital Melbourne - PIN, Parkville, Victoria

UZ Antwerpen, Edegem, Antwerpen

Universitair Ziekenhuis Brussel - PIN, Jette, Brussels

UZ Leuven, Leuven, Vlaams Brabant

University of Alberta Hospital, Edmonton, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

London Health Sciences Centre, London, Ontario

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Beijing Children Hospital,Capital Medical University, Beijing, Beijing

Henan Children's Hospital(Zhengzhou Children's Hospital), Zhengzhou, Henan

Children's Hospital of Fudan University, Shanghai, Shanghai

The Children's Hospital Zhejiang UniversitySchool of Medicine, Hangzhou, Zhejiang

Klinika Za Djecje Bolesti Zagreb, Zagreb, Grad Zagreb

University Hospital Center Zagreb, Zagreb, Grad Zagreb

University Hospital Centre Split, Split, Not set

Fakultni nemocnice Kralovske Vinohrady, Prague, Praha, Hlavni Mesto

Fakultni Thomayerova Nemocnice, Praha, Praha, Hlavni Mesto

Fakultni nemocnice Ostrava, Ostrava, Not set

Attikon University General Hospital, Athens, Attiki

Children's Hospital "Agia Sofia", Athens, Not set

Ippokratio General Hospital of Thessaloniki, Thessaloniki, Not set

Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktato Korhaz, Miskolc, Borsod-Abauj-Zemplen

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged, Csongrad

Semmelweis Egyetem, Budapest, Not set

Schneider Childrens Medical Center of Israel Petah Tikvah PIN, Petah Tikva, HaMerkaz

Tel Aviv Sourasky Medical Center PPDS, Jerusalem, Yerushalayim

Soroka University Medical Centre, Beer Sheba, Not set

Rambam Medical Center - PPDS, Haifa, Not set

Carmel Medical Center, Haifa, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Hadassah Medical Center - PPDS, Jerusalem, Not set

AOU dell'Universita degli Studi della Campania Luigi Vanvitelli, Napoli, Campania

Azienda Ospedaliera Universitaria Federico II, Napoli, Campania

Azienda USL di Bologna, Bologna, Emilia-Romagna

Sapienza University of Rome, Roma, Lazio

ASST di Monza - Azienda Ospedaliera San Gerardo, Monza, Lombardia

Universita degli Studi di Padova, Padova, Veneto

Kurume University Hospital, Kurume-Shi, Hukuoka

Japanese Red Cross Kumamoto Hospital, Kumamoto-shi, Kumamoto

Juntendo University Hospital, Bunkyo-Ku, Tokyo

National Center for Child Health and Development, Setagaya-Ku, Tokyo

Kyungpook National University Chilgok hospital, Daegu, Daegu Gwang'yeogsi

Gachon University Gil Medical Center, Incheon, Incheon Gwang'yeogsi

Seoul National University Hospital, Seongnam, Not set

Samsung Medical Center - PPDS, Seoul, Not set

Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Kaunas, Kauno Apskritis

Vilnius University Hospital Santaros Klinikos, Vilnius, Vilniaus Apskritis

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu, Wroclaw, Dolnoslaskie

Instytut Centrum Zdrowia Matki Polki, Lodz, Lodzkie

Uniwersytecki Szpital Dzieciecy, Krakow, Malopolskie

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Mazowieckie

Instytut Pomnik Centrum Zdrowia Dziecka, Warszawa, Mazowieckie

Korczowski Bartosz, Gabinet Lekarski, Rzeszow, Podkarpackie

Copernicus Podmiot Leczniczy Sp. z o.o., Gdansk, Pomorskie

Gornoslaskie Centrum Zdrowia Dziecka Im. Sw. Jana Pawla II Spsk Nr 6 Sum W Katowicach, Katowice, Slaskie

Twoja Przychodnia SCM, Szczecin, Zachodniopomorskie

SPZOZ Centralny Szpital Kliniczny UM w Lodzi, Lodz, Not set

Detska fakultna nemocnica s poliklinikou Banska Bystrica, Banska Bystrica, Not set

Narodny ustav detskych chorob, Bratislava, Not set

Hospital Sant Joan de Deu - PIN, Esplugues de Llobregat, Barcelona

Hospital de Sagunto, Sagunto, Valencia

Hospital Infantil Universitario Nino Jesus - PIN, Madrid, Not set

Hospital Regional Universitario de Malaga - Hospital Materno Infantil, Malaga, Not set

Hospital Universitario Virgen del Rocio - PPDS, Sevilla, Not set

Kings College Hospital, London, London, City Of

Great Ormond Street Hospital (GOSH), London, London, City Of

Noahs Ark Childrens Hospital for Wales - PPDS - PIN, Cardiff, South Glamorgan

Birmingham Children's Hospital NHS Foundation Trust, Birmingham, West Midlands

Barts Health NHS Trust, London, Not set

Royal Manchester Children's Hospital - PPDS, Manchester, Not set

Conditions: Crohn's Disease (CD)

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Open Lung Protective Extubation Following General Anesthesia

NCT06296173

Recruiting

Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development. Protective "open lung" mechanical ventilation aims to minimize the occurrence of atelectasis during the perioperative period. Randomized controlled studies have been performed comparing various "open lung" ventilation protocols, but these studies report varying and conflicting effects. The interpretation of these studies is complicated by the... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/16/2025

Locations: The Ottawa Hospital, Ottawa, Ontario +3 locations

Conditions: Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury, Atelectasis

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A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)

NCT06346067

Recruiting

Stage 1: To select the optimal dose of naporafenib + trametinib to be studied in Stage 2. Stage 2: To compare progression free survival (PFS) and overall survival (OS) for patients with NRAS-mutant (NRASm) melanoma who are randomized to receive the combination of naporafenib + trametinib to that of patients who are randomized to physician's choice of therapy (dacarbazine, temozolomide, or trametinib monotherapy).

Gender:

ALL

Ages:

Between 18 years and 99 years

Trial Updated:

01/16/2025

Locations: Mayo Clinic - Arizona, Phoenix, Arizona +58 locations

Mayo Clinic - Arizona, Phoenix, Arizona

University of California, San Francisco, San Francisco, California

The Melanoma and Skin Care Institute, Englewood, Colorado

Mayo Clinic - Florida, Jacksonville, Florida

University of Miami Sylvester Cancer, Miami, Florida

University of Kansas Cancer Center, Kansas City, Kansas

Ochsner Clinic Foundation, Jefferson, Louisiana

Massachusetts General Hospital, Boston, Massachusetts

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

Mayo Clinic, Rochester, Minnesota

Washington University School of Medicine, Saint Louis, Missouri

Memorial Sloan Kettering Cancer Center, New York, New York

Cleveland Clinic Foundation, Cleveland, Ohio

SCRI Oncology Partners (formerly Tennessee Oncology), Nashville, Tennessee

Texas Oncology- Austin Midtown, Austin, Texas

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas

The University of Texas MD Anderson Cancer Center, Houston, Texas

The University of Utah - Huntsman Cancer Institute (HCI), Salt Lake City, Utah

Virginia Oncology Associates, Norfolk, Virginia

Fred Hutchinson Cancer Center, Seattle, Washington

University of Wisconsin, Madison, Wisconsin

Calvary Mater Newcastle, Waratah, New South Wales

Tasman Health Care, Southport, Queensland

Princess Alexandra Hospital, Woolloongabba, Queensland

Peter MacCallum Cancer Institute, Melbourne, Victoria

Hollywood Private Hospital, Nedlands, Western Australia

Alfred Hospital, Melbourne, Not set

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia

McGill University Health Centre, Montréal, Quebec

Masarykuv Onkologicky Ustav-MOU, Brno, Not set

Fakultni nemocnice Hradec Kralove, Nový Hradec Králové, Not set

Sanatorium Profesora Arenbergera, Prague, Not set

Centre Hospitalier Universitaire (CHU) de Bordeaux - Hospitalier Saint-Andre, Bordeaux, Not set

CHU Dijon Bourgogne - Hopital Francois Mitterand (Hopital du Bocage), Dijon, Not set

Centre Hospitalier du Mans, Le Mans, Not set

CHRU de Lille - HÃ´pital Claude Huriez, Lille, Not set

Centre Hospitalier Lyon-Sud, Lyon, Not set

Assistance Publique Hopitaux de Marseille (AP-HM) - Hopital de la Timone, Marseille, Not set

Hospital Ambroise Pairs, Paris, Not set

APHP - Hopital Saint Louis, Paris, Not set

CLCC Institute Gustave Roussy, Villejuif, Not set

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele (HSR) (Istituto Scientifico Universitario Sa, Milan, Not set

IRCCS Istituto Nazionale Tumori Regina Elena, Roma, Not set

Istituto Dermopatico dell Immacolata IDI-IRCCS, Roma, Not set

Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Not set

Isala Ziekenhuis, Amsterdam, Not set

Leids Universitair Medisch Centrum, Leiden, Not set

Radboud University, Nijmegen, Not set

Hospital Universitari Vall d'Hebron - Vall d'Hebron Institut d'Oncologia (VHIO), Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital General Universitario Gregorio Marañón, Madrid, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

Hospital HM Sanchinarro, Madrid, Not set

Hospital Universitario Central de Asturias, Oviedo, Not set

Royal Preston Hospital, Preston, Lancashire

Sarah Cannon Research Institute - HCA Healthcare, City of London, London

Royal Devon and Exeter Hospital, Exeter, Not set

The Royal Marsden NHS Foundation Trust, London, Not set

Christie Hospital, Manchester, Not set

Conditions: Advanced or Metastatic NRAS-mutant Melanoma

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