Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
NCT03511118
Recruiting
Over half of women in the US who are breastfeeding their infants take prescription drugs. You are being asked to participate in this study because you are breastfeeding your infant and are currently taking, as part of your medical care, at least one of the drugs we are studying. We are interested in studying drugs commonly prescribed to women who are breastfeeding so we can learn more about the amount of drug that is transferred to breastmilk and estimate how much of drug that is consumed by bre... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/12/2024
Locations: University of California-San Diego Medical Center, La Jolla, California +21 locations
Conditions: Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI
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Post-market Study of the Biodesign Hernia Graft
NCT04294446
Recruiting
The purpose of this study is to collect data on the performance of the Biodesign® Hernia Graft when used to reinforce soft tissues during ventral hernia repair.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee +2 locations
Conditions: Ventral Hernia
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STING MARK Universal Fiducial Marker System
NCT05465161
Recruiting
Currently available fiducial marker and fiducial insertion strategies are rudimentary, imprecise, not compatible with multiple insertion catheters/needles and are overall unreliable. STING-MARK device is the first universal, fully detachable and non-premounted radiopaque fiducial device system. Allowing biopsy prior to insertion, STING-MARK is easily and reliably delivered through-the-needle to the tumor, in order to accurately pinpoint its location for image-guided therapies. This study aims at... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: CHUM, Montréal, Quebec
Conditions: Cancer
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Supporting Patients by Family Education in Psychotic Illness: A Prospective Cohort Study
NCT05500001
Recruiting
Background: A lack of education, resources, and support for family carers of young adults with psychotic illnesses leaves them ill-equipped to support their loved one. Although family support groups exist, few groups offer evidence-based, skills-focused, psychoeducation taught by certified professionals and provided on a public-health level. By equipping families with skills and knowledge, public healthcare harnesses a powerful ally to maintain community stabilization. Aims: The primary study g... Read More
Gender:
ALL
Ages:
Between 17 years and 27 years
Trial Updated:
12/12/2024
Locations: Royal Alexandra Hospital, Edmonton, Alberta +3 locations
Conditions: Psychotic Disorders, Family Members, Anosognosia, Paranoia
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Neuromodulation for Schizophrenia
NCT05580211
Recruiting
Our proposed study employs a novel approach to determine the clinical and functional imaging effects of brainstem neuromodulation, with an investigational study device, on illness awareness in schizophrenia - a significant contributor to medication non-adherence and poor treatment outcomes, and arguably the most treatment resistant manifestation of the disorder. The study device under investigation provides a safe and non-invasive method of brainstem stimulation that will be used in conjunction... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Schizophrenia
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Defining a Technique for the Use of Cryogenic Catheters for Biopsy and Ablation for the Diagnostic and Treatment of Pulmonary Lesions: An Ex-Vivo Human Lung Model Study.
NCT05948904
Recruiting
Developing a standardized methodology for the use of novel cryogenic catheters for transbronchial cryobiopsy and cryoablation of pulmonary lesions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: CHUM, Montréal, Quebec
Conditions: Lung Diseases
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Validation of a System Using Aerosol Glycerine to Detect and Localize Intraoperatively Pulmonary Air Leaks
NCT05971719
Recruiting
Air leaks represent one of the most common complications and postoperative morbidity in thoracic surgery. Air leaks have been associated with the largest preventable morbidity associated with increased costs following lobectomy (typically related to increased length of stay). However, the standard used to detect and localize the air leaks, the submersion test, is not suitable for the standard surgical procedure, Video Assisted Thoracic Surgery. Considering the prevalence of this complication and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: CHUM, Montréal, Not set
Conditions: Air Leak From Lung
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Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective
NCT06322537
Recruiting
All heart surgery patients universally require hydration, which is given through a vein in the arm, but practices for treating patients are not universal. There are disagreements about whether crystalloids should be used alone or in combination with albumin. This question has important implications because albumin is an expensive blood product in relatively limited supply, and 20% of its use is by heart surgery patients. The goal of this study is to learn more about how crystalloids and albumin... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/12/2024
Locations: Royal Columbian Hospital, New Westminster, British Columbia +9 locations
Conditions: Cardiovascular Surgical Procedures, Albumin
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Fragility Fractures of the Pelvis (FFP)
NCT04182776
Recruiting
Prospective data will be collected in approximately 420 patients, above the age of 65, suffering from an FFP type fracture equal to or higher than type II, according to Rommens and Hofmann. Patients will be followed up according to the standard (routine) for up to 1 year after the treatment. Data collection will include underlying disease, treatment details, functional and patient reported outcomes (PRO)s, radiological outcomes, and anticipated or procedure-related adverse events (i.e. complica... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/11/2024
Locations: University of Missouri, Columbia, Missouri +9 locations
Conditions: Pelvic Fracture
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Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer
NCT04812366
Recruiting
The objective of this study is to see if providing an appropriate therapy based on the genomic testing of prostate tumour tissue will result in an improved clinical response. Each participant will be treated with 8 weeks of a luteinizing hormone-releasing hormone agonist (LHRHa) plus apalutamide (APA) while genome sequence characterization is being done. Participants with biopsy specimens deemed unevaluable for genomic testing will remain on LHRHa plus APA for an additional 16 weeks. Participa... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/11/2024
Locations: University of California Davis, Sacramento, California +8 locations
Conditions: Prostate Cancer
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ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
NCT05388708
Recruiting
ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatr... Read More
Gender:
ALL
Ages:
Between 14 days and 20 years
Trial Updated:
12/11/2024
Locations: Children's of Alabama, Birmingham, Alabama +98 locations
Conditions: Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
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Do Intravaginal Devices Reduce Urinary Incontinence in Female Runners?
NCT05773378
Recruiting
More than one in five females experience the embarrassment and shame of urine leakage while exercising and this urinary incontinence (UI) is a substantial barrier to exercise. As many as one in three females with UI report that they limit their physical activity due to incontinence: 11.6% by not exercising at all, 11.3% by exercising less and 12.4% by changing the type of exercise they perform. It is imperative to look for alternatives to manage this condition, as it is a key reason why females... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/11/2024
Locations: McLean Function Measurement Lab, Ottawa, Ontario
Conditions: Urinary Incontinence
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