Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective
NCT06322537
Recruiting
All heart surgery patients universally require hydration, which is given through a vein in the arm, but practices for treating patients are not universal. There are disagreements about whether crystalloids should be used alone or in combination with albumin. This question has important implications because albumin is an expensive blood product in relatively limited supply, and 20% of its use is by heart surgery patients. The goal of this study is to learn more about how crystalloids and albumin... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/12/2024
Locations: Royal Columbian Hospital, New Westminster, British Columbia +9 locations
Conditions: Cardiovascular Surgical Procedures, Albumin
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Fragility Fractures of the Pelvis (FFP)
NCT04182776
Recruiting
Prospective data will be collected in approximately 420 patients, above the age of 65, suffering from an FFP type fracture equal to or higher than type II, according to Rommens and Hofmann. Patients will be followed up according to the standard (routine) for up to 1 year after the treatment. Data collection will include underlying disease, treatment details, functional and patient reported outcomes (PRO)s, radiological outcomes, and anticipated or procedure-related adverse events (i.e. complica... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/11/2024
Locations: University of Missouri, Columbia, Missouri +9 locations
Conditions: Pelvic Fracture
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Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer
NCT04812366
Recruiting
The objective of this study is to see if providing an appropriate therapy based on the genomic testing of prostate tumour tissue will result in an improved clinical response. Each participant will be treated with 8 weeks of a luteinizing hormone-releasing hormone agonist (LHRHa) plus apalutamide (APA) while genome sequence characterization is being done. Participants with biopsy specimens deemed unevaluable for genomic testing will remain on LHRHa plus APA for an additional 16 weeks. Participa... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/11/2024
Locations: University of California Davis, Sacramento, California +8 locations
Conditions: Prostate Cancer
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Olfactory Training As a Treatment for Olfactory Dysfunction Post COVID-19
NCT05384561
Recruiting
Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT). The aim of this study is to assess the clinical outcomes of olfactory training (12 weeks) therapy in the treatment of persistent olfactory dysfunctions after COVID-19. Specially, we aim to compare the effectiveness of two different olfactory training (different odors). A group will train themselve... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/11/2024
Locations: Université du Québec à Trois-Rivières, Trois-Rivières, Quebec
Conditions: Hyposmia, COVID-19, Parosmia, Anosmia, SARS-CoV-2 Infection
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ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
NCT05388708
Recruiting
ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatr... Read More
Gender:
ALL
Ages:
Between 14 days and 20 years
Trial Updated:
12/11/2024
Locations: Children's of Alabama, Birmingham, Alabama +98 locations
Conditions: Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
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Do Intravaginal Devices Reduce Urinary Incontinence in Female Runners?
NCT05773378
Recruiting
More than one in five females experience the embarrassment and shame of urine leakage while exercising and this urinary incontinence (UI) is a substantial barrier to exercise. As many as one in three females with UI report that they limit their physical activity due to incontinence: 11.6% by not exercising at all, 11.3% by exercising less and 12.4% by changing the type of exercise they perform. It is imperative to look for alternatives to manage this condition, as it is a key reason why females... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/11/2024
Locations: McLean Function Measurement Lab, Ottawa, Ontario
Conditions: Urinary Incontinence
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Improving Cognition of Older Adults in Community Housing
NCT05932342
Recruiting
The I-COACH study will focus on seniors with mental health conditions who are living in senior community housing. This initiative proposes to assess the feasibility and acceptability of a 12-week integrated program of cognitive remediation (CR) in combination with social and physical activity using an open-label design. The program will be provided over three iterative groups of six participants each, with one Personal Support Worker (PSW). The program will be co-designed at a granular level in... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
12/11/2024
Locations: Center for Addiction and Mental Health, Toronto, Ontario
Conditions: Aging, Mental Disorder
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Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
NCT06725121
Recruiting
The goal of this clinical trial is to learn if locoregional therapy and immunotherapy can be used together to help patients with hepatocellular carcinoma (HCC) and macrovascular invasion achieve liver transplantation. The main questions it aims to answer are: * How many patients will achieve transplant with this treatment strategy? * What will the 5-year survival and recurrence-free survival rates be for these patients? Participants will: * Undergo a biopsy of the tumor. * Receive locoregion... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/11/2024
Locations: London Health Sciences Centre, London, Ontario +1 locations
Conditions: Hepatocellular Carcinoma (HCC), Macrovascular Invasion, Liver Transplant Surgery, Downstaging
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USG CMBB DSA Study
NCT06731920
Recruiting
Injections that freeze neck joints can be done using x-rays or ultrasound imaging, which as a newer way of guiding the needle to the right spot. This study will look at how often freezing liquid goes into a blood vessel during neck injections that freeze neck joints when ultrasound guidance is used to place the needle. When this happens, it can go undetected because it does not make the patient feel any different, however it could cause a test block to be falsely negative, leading to the wrong d... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
12/11/2024
Locations: Bill Nelems Pain and Research Centre, Kelowna, British Columbia
Conditions: Cervicalgia
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Nature-based Virtual Reality Intervention for Depression in Alzheimer's Disease
NCT06732128
Recruiting
Behavioural and psychological symptoms of dementia (BPSD), such as depression affect up to 90% patients with dementia. Non-pharmacological treatment of BPSD, can be difficult to access, require caregiver support, travel, and often have long waiting lists. Virtual reality (VR) is an innovative, portable, immersive, and accessible technology which can be used in-home. More information is required on the feasibility of using VR in-home with older adults with dementia. Our study will offer a 4-week... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
12/11/2024
Locations: Centre for Addictions and Mental Health (CAMH), Toronto, Ontario
Conditions: Alzheimer Disease, Depression
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Protein Needs Study
NCT04144907
Recruiting
Severe muscle loss in patients with cancer has been associated with increased physical disability, extended hospitalization, infectious and noninfectious complications, increased risk of severe toxicity during cancer treatment, poor quality of life and shortened survival. Adequate protein is key to sustain muscle mass and overall health. However, current nutritional recommendations are not specific or evidence-based. The aim of this project is to determine the protein needs of patients with colo... Read More
Gender:
ALL
Ages:
Between 45 years and 80 years
Trial Updated:
12/10/2024
Locations: University of Alberta, Edmonton, Alberta
Conditions: Colorectal Cancer, Breast Cancer
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Cannabis as a Complementary Treatment in Multiple Sclerosis
NCT05092191
Recruiting
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) afflicting over 77,000 Canadians. Unfortunately, the therapeutic arsenal to relieve MS symptoms is limited. It is therefore essential to develop better approaches to treat the symptoms of MS. The use of cannabis for recreational purposes is now legal in Canada. However, for many years, people with Multiple Sclerosis (PwMS) have used cannabis either to relax, to reduce pain and spasticity, or to improve sleep a... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/10/2024
Locations: CRCHUM, Montreal, Quebec
Conditions: Multiple Sclerosis
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