A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation
NCT04065399
Recruiting
Phase 1 dose escalation will determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of revumenib in participants with acute leukemia. In Phase 2, participants will be enrolled in 3 indication-specific expansion cohorts to determine the efficacy, short- and long-term safety, and tolerability of revumenib.
Gender:
ALL
Ages:
30 days and above
Trial Updated:
11/19/2024
Locations: City of Hope Comprehensive Cancer Center, Duarte, California +56 locations
Conditions: Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia of Ambiguous Lineage
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Impact of FDG-PET/CT on Management of Patients with Native Valve Infective Endocarditis
NCT04792281
Recruiting
The proposed study is a multicentric prospective observational cohort study of patients with suspected NVE. The study population includes those with Possible IE according to the modified Duke criteria and investigated at one of the 6 participating sites which include 2 cardiac centers, the MHI and the IUCPQ, as well as 4 tertiary care centers, the Jewish General Hospital , the McGill University Health Centre and the CHUS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Jewish General Hospital, Montreal, Quebec +5 locations
Conditions: Infective Endocarditis, Native Valve Endocarditis
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A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma
NCT04814108
Recruiting
This is a Phase 2 study to evaluate the clinical activity and safety of ZN-c3 (azenosertib) in adult women with recurrent or persistent uterine serous carcinoma (USC).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Alaska Women's Cancer Care, Anchorage, Alaska +51 locations
Conditions: Uterine Serous Carcinoma
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Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode
NCT04887337
Recruiting
Each year within Canada and the US, more than 30,000 children and adolescents will have an injury to their shoulder resulting in a shoulder dislocation. Although the current practice is to manage this initial dislocation without surgery, the vast majority of these children and adolescents will, unfortunately continue to have instability episodes of their shoulder. Recurrent instability can cause damage to the bones and cartilage that form the shoulder resulting in potentially more difficult surg... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
11/19/2024
Locations: McMaster University, Hamilton, Ontario
Conditions: Shoulder Dislocation
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Sputum-guided Treatment With Comprehensive Care Management in COPD - A Randomized-controlled Trial
NCT04890938
Recruiting
Chronic obstructive pulmonary disease (COPD) is a lung condition affecting 1 in 6 Canadians and does not have a cure. Flare-ups of COPD are the most common reason someone goes to hospital in Canada. This is made worse because within 30-days of having a flare-up, 1 in 5 patients will come back to hospital for the same problem. Flare-ups of COPD often have many causes and these are different person to person. Sometimes it is related to behaviours such as smoking or not using medicines properly. O... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
11/19/2024
Locations: Hamilton General Hospital, Hamilton, Ontario +1 locations
Conditions: COPD
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Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC
NCT04919811
Recruiting
The main purpose of the study is to evaluate safety and efficacy of taletrectinib (also known as AB-106 or DS-6051b) monotherapy in the treatment of advanced NSCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Beverly Hills Cancer Center, Beverly Hills, California +72 locations
Conditions: Non Small Cell Lung Cancer
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Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults.
NCT05035212
Recruiting
Efficacy Study: This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of a single dose of RSVpreF in the prevention of LRTI-RSV in adults: * At a dose of 120µg. * In adults 60 years of age and older. * The duration of the study for each participant will be up to approximately 24 months. * The study will be conducted in the United States, Canada, Netherlands, Finland, Argentina, Japan and South Africa. Substudy A: This s... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/19/2024
Locations: St. Vincent's Birmingham (Pharmacy), Birmingham, Alabama +327 locations
Conditions: Lower Respiratory Tract Illness
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Abatacept in Immune Checkpoint Inhibitor Myocarditis
NCT05335928
Recruiting
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California +30 locations
Conditions: Myocarditis Acute, Cancer
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Pain Informed Movement for People With Knee Osteoarthritis
NCT05730829
Recruiting
The goal of this clinical trial is to compare a pain informed movement program to standard neuromuscular exercise in people with knee osteoarthritis. The main question it aims to answer are: 1. Are the two interventions a) pain informed movement program plus pain neuroscience education and b) neuromuscular exercise plus standard osteoarthritis education feasible in terms of recruitment, treatment adherence, timelines, data collection procedures, patient follow-up, and resources required? 2. Is... Read More
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
11/19/2024
Locations: McMaster University, Hamilton, Ontario
Conditions: Knee Osteoarthritis
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Single Pre-Operative Radiation Therapy - With Delayed or No Surgery (SPORT-DNS)
NCT05217966
Recruiting
Eligible women will receive neoadjuvant single fraction radiotherapy followed by surgery performed after one year
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
11/18/2024
Locations: Maisonneuve-Rosemont Hospital, Montreal, Quebec +1 locations
Conditions: Breast Cancer
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Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
NCT05254730
Recruiting
record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy
Gender:
ALL
Ages:
All
Trial Updated:
11/18/2024
Locations: McGill University, Montreal, Quebec
Conditions: Epilepsy, Refractory
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Senescent Endometrial Cells in Patients with Thin Endometrial Lining
NCT06450301
Recruiting
The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is: Are there any senescent cells present in thin endometrial lining? During the luteal phase of the cycle, participants will will undergo: * Gynecologic US to measure the endometrial lining thickness and pattern. * Endometrial bio... Read More
Gender:
FEMALE
Ages:
Between 18 years and 39 years
Trial Updated:
11/18/2024
Locations: Trio Fertility, Toronto, Ontario
Conditions: Asherman's Syndrome, Thin Endometrial Lining, Cell Senescence
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