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All Clinical Trials in Canada
A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients With Antibody-Mediated Rejection (AMR)
Recruiting
The purpose of this study is to assess the safety, tolerability, and efficacy of efgartigimod PH20 SC given by a prefilled syringe in participants with Antibody-Mediated Rejection (AMR) after kidney transplantation.
After a screening period of up to 6 weeks, eligible participants will be randomized in a 1:1:1 ratio. The study drug will be administered subcutaneously while patients remain on their standard background immunosuppression therapy (tacrolimus, mycophenolate mofetil, steroids) during... Read More
The purpose of this study is to assess the safety, tolerability, and efficacy of efgartigimod PH20 SC given by a prefilled syringe in participants with Antibody-Mediated Rejection (AMR) after kidney transplantation.
After a screening period of up to 6 weeks, eligible participants will be randomized in a 1:1:1 ratio. The study drug will be administered subcutaneously while patients remain on their standard background immunosuppression therapy (tacrolimus, mycophenolate mofetil, steroids) during the treatment period (48 weeks). At the end of the treatment period, the participants will enter an observational/follow-up period (approximately 24 weeks). The participants will be in the study for up to 78 weeks. Read Less
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/14/2025
Locations: University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama +19 locations
University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama
Cedars-Sinai Medical Center, Los Angeles, California
Duke University Hospital, Durham, North Carolina
The Ohio State University Wexner Medical Center, Columbus, Ohio
Virginia Commonwealth University (VCU) Medical Center Hume-Lee Transplant Center, Richmond, Virginia
University of Washington Medical Center, Seattle, Washington
Allgemeines Krankenhaus der Stadt Wien (AKH Wien) - Medizinischer Universitätscampus, Wien, Not set
Universitair Ziekenhuis (UZ) Gent, Gent, Not set
Universitair Ziekenhuis Leuven (UZ Leuven) - Campus Gasthuisberg, Leuven, Not set
London Health Sciences Centre, London, Not set
Institut klinicke a experimentalni mediciny (IKEM), Praha, Not set
Centre Hospitalier Universitaire (CHU) de Bordeaux - Hôpital Pellegrin, Bordeaux, Not set
Centre Hospitalier Universitaire (CHU) de Grenoble Alpes - Hôpital Michallon, La Tronche, Not set
Centre Hospitalier Universitaire (CHU) de Toulouse - Hôpital de Rangueil, Toulouse, Not set
Charité - Universitätsmedizin Berlin, Berlin, Not set
Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set
Hospital Del Mar, Barcelona, Not set
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Hospital Universitario de Bellvitge, Barcelona, Not set
Conditions: Antibody-mediated Rejection
A Study of MK-6837 as a Monotherapy and Combination Therapy in Participants With Advanced/Metastatic Solid Tumors (MK-6837-001)
Recruiting
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of MK-6837, administered as a monotherapy and in combination with pembrolizumab (MK-3475), in participants with histologically or cytologically confirmed advanced/metastatic solid tumors that have not responded to conventional therapy. There will not be any hypothesis testing in the study.
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of MK-6837, administered as a monotherapy and in combination with pembrolizumab (MK-3475), in participants with histologically or cytologically confirmed advanced/metastatic solid tumors that have not responded to conventional therapy. There will not be any hypothesis testing in the study. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Atlantic Health System Morristown Medical Center ( Site 4001), Morristown, New Jersey +6 locations
Atlantic Health System Morristown Medical Center ( Site 4001), Morristown, New Jersey
Providence Portland Medical Center ( Site 4002), Portland, Oregon
South Texas Accelerated Research Therapeutics (START) ( Site 4003), San Antonio, Texas
Westmead Hospital ( Site 1002), Westmead, New South Wales
The Alfred Hospital ( Site 1001), Melbourne, Victoria
Princess Margaret Cancer Centre ( Site 2001), Toronto, Ontario
Sheba Medical Center-ONCOLOGY ( Site 3001), Ramat Gan, Not set
Conditions: Neoplasm Metastasis
A Phase 2a/b Study of the Efficacy and Safety of Subcutaneous Amlitelimab in Adults With Nonresponsive Celiac Disease
Recruiting
This is a Phase 2a/b, randomized, double-blind, placebo-controlled, parallel-group, 6-arm study to evaluate the efficacy and safety of amlitelimab in adult participants with non-responsive celiac disease (NRCD) who are on a gluten free diet (GFD) with and without simulated inadvertent gluten exposure (SIGE).
The primary purpose of this study is to demonstrate the efficacy of subcutaneous (SC) amlitelimab in male and female participants (aged 18 to 75 years, inclusive) with NRCD. The study will... Read More
This is a Phase 2a/b, randomized, double-blind, placebo-controlled, parallel-group, 6-arm study to evaluate the efficacy and safety of amlitelimab in adult participants with non-responsive celiac disease (NRCD) who are on a gluten free diet (GFD) with and without simulated inadvertent gluten exposure (SIGE).
The primary purpose of this study is to demonstrate the efficacy of subcutaneous (SC) amlitelimab in male and female participants (aged 18 to 75 years, inclusive) with NRCD. The study will assess the effect of amlitelimab when compared to placebo on gluten induced changes in the intestinal mucosa as measured by the villous height to crypt depth (Vh:Cd) ratio. The effect of amlitelimab on participant-reported celiac signs and symptoms along with the safety, tolerability, and pharmacokinetics of amlitelimab will also be studied.
Study details include:
The study duration will be up to 48 weeks (including a 16-week safety follow-up period) with 10 visits for participants who opt not to enter the optional long-term extension.
The study duration will be up to 172 weeks (including an 8-week safety follow-up period) with 22 visits for participants who enter the optional long-term extension.
The double-blind placebo-controlled treatment duration will be up to 28 weeks. Read Less
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/14/2025
Locations: FOMAT Medical Research - inSite Digestive Health Care - Arcadia- Site Number : 8400052, Arcadia, California +110 locations
FOMAT Medical Research - inSite Digestive Health Care - Arcadia- Site Number : 8400052, Arcadia, California
Ventura County Gastroenterology Medical Group- Site Number : 8400010, Camarillo, California
Om Research - Lancaster - 15th Street West- Site Number : 8400001, Lancaster, California
United Gastroenterologists - Los Alamitos- Site Number : 8400014, Los Alamitos, California
Advanced Research Institute - Denver- Site Number : 8400048, Denver, Colorado
Wellness Clinical Research - Miami Lakes - 8181 Northwest 154th Street- Site Number : 8400040, Miami Lakes, Florida
GI Pros- Site Number : 8400034, Naples, Florida
GCP Clinical Research- Site Number : 8400007, Tampa, Florida
Archbold Memorial Hospital- Site Number : 8400044, Thomasville, Georgia
Hutchinson Clinic- Site Number : 8400020, Hutchinson, Kansas
Boston Specialists- Site Number : 8400051, Boston, Massachusetts
Berkshire Medical Center, Inc.- Site Number : 8400017, Pittsfield, Massachusetts
Gastroenterology Associates of Western Michigan, P.L.C.- Site Number : 8400004, Wyoming, Michigan
Mayo Clinic Hospital Rochester- Site Number : 8400049, Rochester, Minnesota
Washington University- Site Number : 8400025, Saint Louis, Missouri
Advanced Research Institute- Site Number : 8400036, Reno, Nevada
Sanmora Bespoke Clinical Research Solutions- Site Number : 8400015, East Orange, New Jersey
Allied Health Clinical Research Organization, LLC- Site Number : 8400053, Freehold, New Jersey
Ospedale Maggiore Policlinico Milano-Site Number : 3800002, Charlotte, North Carolina
M3-Emerging Medical Research- Site Number : 8400008, Raleigh, North Carolina
Velocity Clinical Research - Providence- Site Number : 8400002, East Greenwich, Rhode Island
ClinSearch - Chattanooga - Shallowford Road- Site Number : 8400012, Chattanooga, Tennessee
Quality Medical Research- Site Number : 8400018, Nashville, Tennessee
Advanced Research Institute- Site Number : 8400030, Cedar Park, Texas
MedCare Pharma - Houston - Cypress Creek Parkway- Site Number : 8400016, Houston, Texas
LinQ Research, LLC- Site Number : 8400028, Pearland, Texas
DM Clinical Research - Tomball- Site Number : 8400042, Tomball, Texas
Advanced Research Institute - Sandy- Site Number : 8400046, Sandy, Utah
Velocity Clinical Research - Salt Lake City- Site Number : 8400023, West Jordan, Utah
Clinical Research Partners - Richmond - Forest Avenue- Site Number : 8400011, Richmond, Virginia
GI Alliance- Site Number : 8400033, Tacoma, Washington
Investigational Site Number : 0320010, Quilmes, Buenos Aires
Investigational Site Number : 0320008, San Isidro, Buenos Aires
Investigational Site Number : 0320005, Rosario, Santa Fe
Investigational Site Number : 0320002, San Miguel de Tucumán, Tucumán
Investigational Site Number : 0320007, Buenos Aires, Not set
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320003, Córdoba, Not set
Investigational Site Number : 0360002, Sydney, New South Wales
Investigational Site Number : 0360001, Mackay, Queensland
Investigational Site Number : 0320012, Maroochydore, Queensland
Investigational Site Number : 0360005, Melbourne, Victoria
Investigational Site Number : 0560002, Brussels, Not set
Investigational Site Number : 0560001, Leuven, Not set
Hospital Sao Rafael- Site Number : 0760005, Salvador, Bahia
Centro de Pesquisas da Clínica IBIS- Site Number : 0760006, Salvador, Bahia
Chronos Pesquisa Clínica- Site Number : 0760002, Brasília, Distrito Federal
Centro de Diagnostico e Pesquisa da Osteoporose do Espirito Santo- Site Number : 8400013, Vitoria, Espírito Santo
Hospital Moinhos de Vento- Site Number : 0760004, Porto Alegre, Rio Grande Do Sul
Hospital São Lucas da PUCRS - Porto Alegre - Avenida Ipiranga- Site Number : 0760001, Porto Alegre, Rio Grande Do Sul
Praxis Pesquisa Medica- Site Number : 0760008, Santo Andre, São Paulo
Investigational Site Number : 1240001, Vancouver, British Columbia
Investigational Site Number : 1240002, Victoria, British Columbia
Investigational Site Number : 1520006, Concepción, Biobío
Investigational Site Number : 1520005, Talcahuano, Biobío
Investigational Site Number : 1520007, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520004, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 2030002, Brno, Not set
Investigational Site Number : 2030006, Havířov, Not set
Investigational Site Number : 2030005, Klatovy, Not set
Investigational Site Number : 2030001, Prague, Not set
Investigational Site Number : 2030003, Prague, Not set
Investigational Site Number : 0320009, Kuopio, Buenos Aires
Investigational Site Number : 2460002, Helsinki, Not set
Investigational Site Number : 2460003, Tampere, Not set
Investigational Site Number : 2460001, Turku, Not set
Centre Hospitalier Universitaire de Bordeaux - Hopital Pellegrin Tripode- Site Number : 8400006, Bordeaux, Idaho
Investigational Site Number : 2500002, Nice, Not set
Investigational Site Number : 2500001, Paris, Not set
Investigational Site Number : 2760004, Berlin, Not set
Investigational Site Number : 2760001, Halle, Not set
Investigational Site Number : 2760002, Mainz, Not set
Investigational Site Number : 3000001, Athens, Not set
Investigational Site Number : 3000002, Athens, Not set
Investigational Site Number : 3760002, Afula, Not set
Investigational Site Number : 3760006, Be'er Sheva, Not set
Investigational Site Number : 3760004, Jerusalem, Not set
Investigational Site Number : 3760003, Petah Tikva, Not set
Investigational Site Number : 3760007, Ramat Hasharon, Not set
Investigational Site Number : 3760001, Rehovot, Not set
Azienda Ospedaliera di Padova-Site Number : 3800004, Padova, Veneto
Ospedale di Cisanello-Site Number : 3800003, Pisa, Not set
Investigational Site Number : 5280001, Amsterdam, Not set
Investigational Site Number : 5280002, Arnhem, Not set
Investigational Site Number : 6160005, Wroclaw, Dolnoslaskie
Investigational Site Number : 6160001, Krakow, Malopolskie
Investigational Site Number : 6160002, Warsaw, Mazowieckie
Investigational Site Number : 6160004, Poznan, Wielkopolskie
Investigational Site Number : 7030001, Košice, Not set
Investigational Site Number : 7030003, Nitra, Not set
Investigational Site Number : 7030004, Šahy, Not set
Investigational Site Number : 7240006, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240009, Chiclana de La Frontera, Cádiz
Investigational Site Number : 7240002, Seville, Sevilla
Investigational Site Number : 7240007, Madrid, Not set
Investigational Site Number : 7240003, Madrid, Not set
Investigational Site Number : 7240004, Málaga, Not set
Investigational Site Number : 7240008, Sevilla, Not set
Investigational Site Number : 7522001, Linköping, Not set
Investigational Site Number : 7521001, Mölndal, Not set
Investigational Site Number : 7520003, Stockholm, Not set
Investigational Site Number : 7520001, Uppsala, Not set
Investigational Site Number : 7920004, Antalya, Not set
Investigational Site Number : 7920003, Gaziantep, Not set
Investigational Site Number : 7920006, Istanbul, Not set
Investigational Site Number : 7920001, Mersin, Not set
Investigational Site Number : 7920005, Sanliurfa, Not set
Investigational Site Number : 7920002, Zonguldak, Not set
Investigational Site Number : 8260001, Oxford, Oxfordshire
Investigational Site Number : 8260002, Sheffield, Not set
Conditions: Coeliac Disease, Celiac Disease
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)
Recruiting
Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat MASH.The goals of this study are to learn:
* If efinopegdutide can lower the amount of fat, inflammation, and scarring (fibrosis) in the liver
* About the safety of efinopegdutide and how well peopl... Read More
Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat MASH.The goals of this study are to learn:
* If efinopegdutide can lower the amount of fat, inflammation, and scarring (fibrosis) in the liver
* About the safety of efinopegdutide and how well people tolerate it Read Less
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/14/2025
Locations: The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149), Chandler, Arizona +64 locations
The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149), Chandler, Arizona
Arizona Clinical Trials ( Site 0158), Flagstaff, Arizona
The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0120), Peoria, Arizona
The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 0111), Tucson, Arizona
California Liver Research Institute ( Site 0113), Pasadena, California
Acclaim Clinical Research ( Site 0137), San Diego, California
Velocity Clinical Research, Panorama City ( Site 0124), Van Nuys, California
Rocky Mountain Gastroenterology ( Site 0127), Littleton, Colorado
Synergy Healthcare ( Site 0118), Bradenton, Florida
Homestead Associates in Research, Inc. ( Site 0139), Homestead, Florida
Florida Research Institute ( Site 0116), Lakewood Ranch, Florida
Floridian Clinical Research, LLC ( Site 0109), Miami Lakes, Florida
Southeast Clinical Research Center ( Site 0119), Dalton, Georgia
Delta Research Partners ( Site 0160), Bastrop, Louisiana
Louisiana Research Center ( Site 0161), Shreveport, Louisiana
Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 0130), Glen Burnie, Maryland
Velocity Clinical Research Rockville ( Site 0143), Rockville, Maryland
Huron Gastroenterology ( Site 0102), Ypsilanti, Michigan
The Machuca Foundation ( Site 0115), Las Vegas, Nevada
Excel Clinical Research, LLC ( Site 0101), Las Vegas, Nevada
Southwest Gastroenterology Associates ( Site 0129), Albuquerque, New Mexico
Coastal Research Institute - Fayetteville ( Site 0159), Fayetteville, North Carolina
Lucas Research, Inc ( Site 0105), Morehead City, North Carolina
Texas Clinical Research Institute ( Site 0126), Arlington, Texas
Pinnacle Clinical Research ( Site 0104), Austin, Texas
Pinnacle Clinical Research-Corpus Christi ( Site 0156), Corpus Christi, Texas
Zenos Clinical Research ( Site 0136), Dallas, Texas
GI Alliance Department of Research ( Site 0162), Fort Worth, Texas
Houston Research Institute ( Site 0172), Houston, Texas
Houston Research Institute ( Site 0117), Houston, Texas
American Research Corporation ( Site 0131), San Antonio, Texas
Pinnacle Clinical Research-Clinical Research Coordination ( Site 0125), San Antonio, Texas
Flinders Medical Centre-Hepatology and Liver Transplant Medicine ( Site 1202), Adelaide, South Australia
St Vincent's Hospital-Gastroenterology Department ( Site 1205), Melbourne, Victoria
Toronto General Hospital ( Site 0207), Toronto, Ontario
Diex Recherche Quebec ( Site 0204), Quebec, Not set
Fundacion Santa Fe de Bogota ( Site 0403), Bogotá, Cundinamarca
Fundación Valle del Lili ( Site 0402), Cali, Valle Del Cauca
CHU Bordeaux Haut-Leveque-Service d'Hépato-gastroentérologie ( Site 0701), Pessac, Aquitaine
Hôpital Beaujon-Hépatologie ( Site 0703), Clichy, Hauts-de-Seine
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren-Hépato-gastroentérologie ( Site 0702), Limoges, Limousin
Hôpital de la Croix Rousse-Centre de Recherche Clinique ( Site 0705), Lyon, Rhone-Alpes
Rambam Health Care Campus ( Site 0801), Haifa, Not set
Carmel Hospital-Liver Unit ( Site 0802), Haifa, Not set
Shaare Zedek Medical Center ( Site 0805), Jerusalem, Not set
Maccabi Health Services - Petah Tikva ( Site 0804), Petah Tikva, Not set
Shinyurigaoka General Hospital ( Site 1401), Kawasaki, Kanagawa
Yokohama City University Hospital ( Site 1402), Yokohama, Kanagawa
University Hospital,Kyoto Prefectural University of Medicine ( Site 1404), Kyoto, Not set
Osaka Metropolitan University Hospital ( Site 1403), Osaka, Not set
Saga University Hospital ( Site 1405), Saga, Not set
ISIS CLINICAL RESEARCH CENTER ( Site 0606), Guaynabo, Not set
Klinical Investigations Group-Clinical Research ( Site 0601), San Juan, Not set
Hospital Universitario Marqués de Valdecilla-Gastroenterology and Hepatology ( Site 1004), Santander, Cantabria
Hospital Clínico Universitario de Valladolid-Servicio de Endocrinologia y Nutricion ( Site 1008), Valladolid, Castilla Y Leon
Hospital General de Tomelloso-Aparato Digestivo ( Site 1006), Tomelloso, Ciudad Real
CHUAC-Complejo Hospitalario Universitario A Coruña-Endocrinología ( Site 1007), A Coruña, La Coruna
CHUS - Hospital Clinico Universitario ( Site 1011), Santiago de Compostela, La Coruna
Hospital Universitari Vall d'Hebron-Liver Unit - Department of Internal Medicine ( Site 1002), Barcelona, Not set
Hospital Universitario La Paz-HEPATOLOGIA ( Site 1005), Madrid, Not set
HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Unidad de Ensayos clinicos de Aparato Digestivo ( Site 1001), Sevilla, Not set
Chulalongkorn University ( Site 1301), Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 1302), Bangkok, Krung Thep Maha Nakhon
King's College Hospital ( Site 1104), London, London, City Of
Aberdeen Royal Infirmary-Department of Gastroenterology ( Site 1102), Aberdeen, Scotland
Conditions: Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, NAFLD, Metabolic Dysfunction-associated Steatotic Liver Disease, Metabolic Dysfunction-associated Steatohepatitis
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Study Participants With Active Psoriatic Arthritis
Recruiting
The purpose of the study is to compare the efficacy of bimekizumab versus risankizumab after 16 weeks of treatment in study participants with active psoriatic arthritis (PsA).
The purpose of the study is to compare the efficacy of bimekizumab versus risankizumab after 16 weeks of treatment in study participants with active psoriatic arthritis (PsA). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Pa0016 50662, Gilbert, Arizona +143 locations
Pa0016 50662, Gilbert, Arizona
Pa0016 50062, Glendale, Arizona
Pa0016 50058, Phoenix, Arizona
Pa0016 50677, Scottsdale, Arizona
Pa0016 50131, Sun City, Arizona
Pa0016 50654, Covina, California
Pa0016 50301, La Jolla, California
Pa0016 50663, San Diego, California
Pa0016 50672, Santa Monica, California
Pa0016 50239, Brandon, Florida
Pa0016 50630, Clearwater, Florida
Pa0016 50679, Cutler Bay, Florida
Pa0016 50685, Fort Lauderdale, Florida
Pa0016 50059, Ormond Beach, Florida
Pa0016 50324, Plantation, Florida
Pa0016 50678, Zephyrhills, Florida
Pa0016 50651, Skokie, Illinois
Pa0016 50650, Willowbrook, Illinois
Pa0016 50686, Hagerstown, Maryland
Pa0016 50665, Lansing, Michigan
Pa0016 50551, Saint Clair Shores, Michigan
Pa0016 50689, Eagan, Minnesota
Pa0016 50682, Kansas City, Missouri
Pa0016 50016, Saint Louis, Missouri
Pa0016 50653, Albuquerque, New Mexico
Pa0016 50666, Brooklyn, New York
Pa0016 50521, New York, New York
Pa0016 50664, Middletown, Ohio
Pa0016 50680, Vandalia, Ohio
Pa0016 50652, Duncansville, Pennsylvania
Pa0016 50006, Wyomissing, Pennsylvania
Pa0016 50001, Jackson, Tennessee
Pa0016 50048, Baytown, Texas
Pa0016 50687, Dallas, Texas
Pa0016 50673, Fort Worth, Texas
Pa0016 50657, Lubbock, Texas
Pa0016 50655, Tomball, Texas
Pa0016 50027, Seattle, Washington
Pa0016 50061, Spokane, Washington
Pa0016 50674, Glendale, Wisconsin
Pa0016 30002, Clayton, Not set
Pa0016 30034, Footscray, Not set
Pa0016 30033, Heidelberg, Not set
Pa0016 30003, Maroochydore, Not set
Pa0016 30032, Parramatta, Not set
Pa0016 30009, Westmead, Not set
Pa0016 40313, Pleven, Not set
Pa0016 40006, Plovdiv, Not set
Pa0016 40813, Plovdiv, Not set
Pa0016 40818, Plovdiv, Not set
Pa0016 40820, Plovdiv, Not set
Pa0016 40823, Ruse, Not set
Pa0016 40656, Russe, Not set
Pa0016 40314, Sofia, Not set
Pa0016 40380, Sofia, Not set
Pa0016 40811, Sofia, Not set
Pa0016 40819, Sofia, Not set
Pa0016 50041, Quebec, Not set
Pa0016 50658, St. John's, Not set
Pa0016 50044, Trois-rivieres, Not set
Pa0016 40065, Brno, Not set
Pa0016 40062, Ostrava, Not set
Pa0016 40802, Ostrava, Not set
Pa0016 40066, Praha 2, Not set
Pa0016 40801, Praha 4, Not set
Pa0016 40010, Uherske Hradiste, Not set
Pa0016 40012, Zlin, Not set
Pa0016 40073, Bad Nauheim, Not set
Pa0016 40025, Berlin, Not set
Pa0016 40515, Berlin, Not set
Pa0016 40138, Bonn, Not set
Pa0016 40808, Cologne, Not set
Pa0016 40072, Freiburg, Not set
Pa0016 40029, Hamburg, Not set
Pa0016 40810, Herne, Not set
Pa0016 40724, München, Not set
Pa0016 40800, Ratingen, Not set
Pa0016 40814, Tuebingen, Not set
Pa0016 40081, Budapest, Not set
Pa0016 40804, Budapest, Not set
Pa0016 40809, Hodmezovasarhely, Not set
Pa0016 40031, Szeged, Not set
Pa0016 20035, Bunkyo-ku, Not set
Pa0016 20043, Itabashi-ku, Not set
Pa0016 20045, Kita-gun, Not set
Pa0016 20049, Kitakyushu, Not set
Pa0016 20069, Meguro-ku, Not set
Pa0016 20336, Mitaka-shi, Not set
Pa0016 20033, Nagoya, Not set
Pa0016 20041, Osaka, Not set
Pa0016 20046, Osaka, Not set
Pa0016 20031, Sapporo, Not set
Pa0016 20335, Yokohama, Not set
Pa0016 40789, Bialystok, Not set
Pa0016 40791, Bialystok, Not set
Pa0016 40824, Bialystok, Not set
Pa0016 40119, Bydgoszcz, Not set
Pa0016 40798, Bydgoszcz, Not set
Pa0016 40038, Elblag, Not set
Pa0016 40795, Katowice, Not set
Pa0016 40092, Krakow, Not set
Pa0016 40490, Krakow, Not set
Pa0016 40502, Krakow, Not set
Pa0016 40792, Krakow, Not set
Pa0016 40037, Lublin, Not set
Pa0016 40483, Nadarzyn, Not set
Pa0016 40091, Nowa Sól, Not set
Pa0016 40796, Olsztyn, Not set
Pa0016 40794, Opole, Not set
Pa0016 40044, Poznan, Not set
Pa0016 40090, Poznan, Not set
Pa0016 40807, Poznan, Not set
Pa0016 40790, Sochaczew, Not set
Pa0016 40788, Torun, Not set
Pa0016 40094, Warszawa, Not set
Pa0016 40394, Warszawa, Not set
Pa0016 40539, Warszawa, Not set
Pa0016 40604, Warszawa, Not set
Pa0016 40793, Warszawa, Not set
Pa0016 40797, Warszawa, Not set
Pa0016 40043, Wroclaw, Not set
Pa0016 40095, Wroclaw, Not set
Pa0016 40805, Wroclaw, Not set
Pa0016 40806, A Coruna, Not set
Pa0016 40269, Bilbao, Not set
Pa0016 40105, Cordoba, Not set
Pa0016 40231, Madrid, Not set
Pa0016 40102, Málaga, Not set
Pa0016 40803, Sabadell, Not set
Pa0016 40753, Santiago de Compostela, Not set
Pa0016 40049, Sevilla, Not set
Pa0016 40799, Sevilla, Not set
Pa0016 40099, Vigo, Not set
Pa0016 40833, Barnet, Not set
Pa0016 40829, Cambridge, Not set
Pa0016 40281, Leeds, Not set
Pa0016 40113, London, Not set
Pa0016 40827, Luton, Not set
Pa0016 40237, Manchester, Not set
Pa0016 40306, Newcastle Upon Tyne, Not set
Pa0016 40812, Peterborough, Not set
Pa0016 40828, Reading, Not set
Pa0016 40108, Salford, Not set
Pa0016 40825, Wolverhampton, Not set
Conditions: Psoriatic Arthritis
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
Recruiting
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug.
The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM.
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug.
The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +96 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
USC/Norris Comprehensive Cancer Center, Los Angeles, California
University of California, Davis Comprehensive Cancer Center, Sacramento, California
UC San Diego Moores Cancer Center, San Diego, California
University of California San Francisco Medical Center, San Francisco, California
UCLA Department of Medicine-Hematology/Oncology, Santa Monica, California
Stanford Cancer Institute, Stanford, California
Colorado Blood Cancer Institute, Denver, Colorado
Moffitt Cancer Center, Tampa, Florida
Winship Cancer Institute, Atlanta, Georgia
IU Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana
Norton Cancer Institute, St. Matthews Campus, Louisville, Kentucky
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
University of Michigan, Ann Arbor, Michigan
Corewell Health - Lemmen-Holton Cancer Pavilion, Grand Rapids, Michigan
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York
Novant Health Cancer Institute Hematology, Charlotte, North Carolina
Novant Health Cancer Institute Hematology- Forsyth, Winston-Salem, North Carolina
University of Cincinnati Medical Center, Cincinnati, Ohio
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
Oregon Health and Science University, Portland, Oregon
University of Tennessee Medical Center, Knoxville, Tennessee
Baptist Cancer Center, Memphis, Tennessee
Henry-Joyce Cancer Clinic, Nashville, Tennessee
St. David's South Austin Medical Center, Austin, Texas
Houston Methodist Hospital Cancer Center, Houston, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Swedish Cancer Institute, Seattle, Washington
University of Washington Medical Center, Seattle, Washington
Royal Prince Alfred Hospital, Camperdown, New South Wales
Royal North Shore Hospital, St. Leonards, New South Wales
Royal Adelaide Hospital, Adelaide, South Australia
Epworth HealthCare, Richmond, Victoria
Sir Charles Gairdner Hospital, Nedlands, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Hamatologie mit Stammzelltransplantation, Hamostaseologie und medizinische Onkologie, Linz, Not set
Paracelsus Medizinischen Privatuniversitaet, Salzburg, Not set
University Hospital St. Poelten, Department of Internal Medicine I, St. Poelten, Not set
Medical University of Vienna, Wien, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
University Hospital of Antwerp, Edegem, Not set
UZ Leuven, Flemish Brabant, Not set
UZ Gent, Gent Oost-Vlaanderen, Not set
QEII Health Sciences Centre, Halifax, Not set
University Health Network - The Princess Margaret Cancer Centre, Toronto, Not set
CHU de Lille- Hopital Claude Huriez, Lille, Not set
Institut Paoli Calmettes, Marseille, Not set
CHU De Montpellier - Hopital Saint Eloi, Montpellier, Not set
Centre Hospitalier Universitaire de Nantes, Nantes, Not set
Hopital Saint Louis, Paris, Not set
Hopital Saint Antoine, Paris, Not set
Hôpital Lyon Sud, Pierre-Benite, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
CHU de Rennes, Rennes, Not set
CHU de Toulouse. IUCT Oncopole, Toulouse, Not set
Universitatsklinikum Hamburg Eppendorf, Hamburg, Not set
Universitatsklinikum Koln, Klinik I fOr lnnere Medizin, Köln, Not set
Universitatsklinikum Leipzig, Leipzig, Not set
TUM Klinikum, Rechts der Isar, Klinik und Poliklinik fur Innere Medizin III, Hamatologie und Onkologie, München, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, MI
IRCCS AOU di Bologna, Bologna, Not set
Ospedale San Raffaele, Milano, Not set
AOU Città della Salute e della Scienza Presidio Ospedaliero Molinette, Torino, Not set
Hyogo Medical University Hospital, Hyogo, Not set
Nagoya City University Hospital, Nagoya City, Not set
The University of Osaka Hospital, Osaka, Not set
Hamamatsu University Hospital, Shizuoka, Not set
Jichi Medical University Hospital, Tochigi, Not set
Juntendo University School of Medicine Juntendo Clinic, Tokyo, Not set
Japanese Red Cross Medical Center, Tokyo, Not set
Amsterdam UMC - Location vUmc, Amsterdam, Not set
University Medical Center Groningen, Groningen, Not set
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wroclaw, Not set
ICO Badalona-H.U. Germans Trias i Pujol, Badalona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital Duran i Reynals, Barcelona, Not set
Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital Universitario Ramon Y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Universitario Virgen del Rocio, Seville, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Inselspital - Universitätsspital Bern, Berne, Not set
Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
University Hospitals Bristol NHS Foundation Trust, Bristol Haematology and Oncology Centre, Bristol, Not set
University Hospital of Wales, Cardiff, Not set
Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, Not set
King's College Hospital, London, Not set
University College London Hospital, London, Not set
Newcastle Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle, Not set
Conditions: Multiple Myeloma
Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma
Recruiting
The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy vs placebo in combination with R-CHOP chemotherapy in participants with previously untreated high-risk large B-cell lymphoma (LBCL).
The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy vs placebo in combination with R-CHOP chemotherapy in participants with previously untreated high-risk large B-cell lymphoma (LBCL). Read Less
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/14/2025
Locations: USA Mitchell Cancer Institute, Mobile, Alabama +343 locations
USA Mitchell Cancer Institute, Mobile, Alabama
Alaska Oncology and Hematology, Anchorage, Alaska
Mayo Clinic in Arizona - Phoenix, Phoenix, Arizona
Local Institution - 0342, San Francisco, California
Florida Cancer Specialists - South, Fort Myers, Florida
Mayo Clinic in Florida, Jacksonville, Florida
D&H Cancer Research Center LLC, Margate, Florida
Mount Sinai Cancer Center, Miami Beach, Florida
Sacred Heart Medical Oncology Group, Pensacola, Florida
Florida Cancer Specialists - North, Saint Petersburg, Florida
Moffitt Cancer Center, Tampa, Florida
Florida Cancer Specialists - East, West Palm Beach, Florida
Cleveland Clinic Florida, Weston, Florida
Emory University School of Medicine- Grady Campus, Atlanta, Georgia
Winship Cancer Institute, Emory University, Atlanta, Georgia
Local Institution - 0182, Chicago, Illinois
Orchard Healthcare Research Inc., Skokie, Illinois
Mission Cancer + Blood, Waukee, Iowa
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
Local Institution - 0436, Edgewood, Kentucky
Mary Bird Perkins Cancer Center Baton Rouge, Baton Rouge, Louisiana
University of Michigan, Ann Arbor, Michigan
Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis, Minnesota
Mayo Clinic in Rochester, Minnesota, Rochester, Minnesota
Local Institution - 0437, Kansas City, Missouri
Cancer Care Specialists, Reno, Nevada
Astera Cancer Care, East Brunswick, New Jersey
Local Institution - 0480, Hackensack, New Jersey
Atlantic Health System Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Local Institution - 0190, Buffalo, New York
Hematology-Oncology Associates of Central New York, PC, East Syracuse, New York
Local Institution - 0484, New York, New York
Local Institution - 0369, New York, New York
Icahn School of Medicine at Mount Sinai, New York, New York
Local Institution - 0174, Chapel Hill, North Carolina
Local Institution - 0066, Massillon, Ohio
Oklahoma Cancer Specialists and Research Institute, Tulsa, Oklahoma
Oregon Health and Science University, Portland, Oregon
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
WellSpan Oncology Research, York, Pennsylvania
Brooke Army Medical Center, Fort Sam Houston, Texas
Local Institution - 0516, Houston, Texas
Memorial Hermann Hospital - Texas Medical Center, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
Virginia Commonwealth University (VCU) Medical Center, Richmond, Virginia
Local Institution - 0465, Tacoma, Washington
Hospital Aleman, Buenos Aires, Ciudad Autónoma De Buenos Aires
Local Institution - 0421, Buenos Aires, Ciudad Autónoma De Buenos Aires
Clínica Zabala, Buenos Aires, Not set
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC), Buenos Aires, Not set
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Not set
Hospital Privado Universitario de Córdoba, Córdoba, Not set
Gosford Hospital, Gosford, New South Wales
Campbelltown Hospital, Sydney, New South Wales
Westmead Hospital, Westmead, New South Wales
Royal Darwin Hospital, Tiwi, Northern Territory
Sunshine Coast University Hospital, Birtinya, Queensland
Gold Coast University Hospital, Southport, Queensland
Peninsula Private Hospital, Frankston, Victoria
Austin Health, Heidelberg, Victoria
Western Health-Sunshine & Footscray Hospitals, St Albans, Victoria
South West Healthcare, Warrnambool, Victoria
Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich
Kepler Universitätsklinikum, Linz, Not set
Local Institution - 0386, Vienna, Not set
Núcleo de Oncologia e Hematologia do Ceará, Fortaleza, Ceara
Hospital Brasilia, Lago sul, Distrito Federal
Universidade Federal de Goias, Goiania, Goias
Hospital Erasto Gaertner, Curitiba, Paraná
CHN - Complexo Hospitalar de Niterói, Niteroi, Rio De Janeiro
Liga Norte Riograndense Contra o Câncer, Natal, Rio Grande Do Norte
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre, Rio Grande Do Sul
Clínica Supera, Chapecó, Santa Catarina
Instituto Joinvilense de Hematologia e Oncologia, Joinville, Santa Catarina
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, São Paulo
Hospital Amaral Carvalho, Jaú, São Paulo
Hospital Alemao Oswaldo Cruz, Sao Paulo, São Paulo
A. C. Camargo Cancer Center, Sao Paulo, São Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo
Hospital São Lucas de Copacabana, Rio de Janeiro, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, Not set
Hospital 9 De Julho, São Paulo, Not set
Hospital das Clinicas FMUSP, São Paulo, Not set
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo, Not set
University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD, Plovdiv, Not set
Local Institution - 0392, Sofia, Not set
UMHAT 'Sveti Ivan Rilsky', Sofia, Not set
Local Institution - 0492, Edmonton, Alberta
BC Cancer Victoria, Victoria, British Columbia
St. Marys Hospital Center, Montreal, Quebec
Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - Hôpital du Sacré-Coeur, Montreal, Quebec
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUS, Sherbrooke, Quebec
Local Institution - 0109, Chile, Región Metropolitana De Santiago
Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago
Clínica Inmunocel, Santiago, Región Metropolitana De Santiago
Clínica UC San Carlos de Apoquindo, Santiago, Región Metropolitana De Santiago
Clínica Alemana de Santiago, Santiago, Región Metropolitana De Santiago
Bradfordhill, Santiago, Región Metropolitana De Santiago
Centro de Investigaciones, Viña del Mar, Valparaíso
Peking University Third Hospital, Beijing, Beijing
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Fujian Cancer Hospital, Fuzhou, Fujian
The First Affiliated hospital of Xiamen University, Xiamen, Fujian
Southern Medical University Nanfang Hospital, Guangzhou, Guangdong
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang
Henan Cancer Hospital, Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Hubei
Hunan Cancer Hospital, Changsha, Hunan
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
Jiangxi Provincial Cancer Hospital, Nanchang, Jiangxi
The First Hospital of Jilin University, Changchun, Jilin
The First Hospital of China Medical University, Shenyang, Liaoning
Shengjing Hospital of China Medical University, 沈阳市, Liaoning
Qilu Hospital of Shandong University, Jinan, Shandong
Shandong Cancer Hospital, Jinan, Shandong
Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai
Fudan University Shanghai Cancer Center, Shanghai, Shanghai
Shanxi Bethune Hospital, Taiyuan, Shanxi
West China Hospital, Sichuan University, Cheng Du, Sichuan
Local Institution - 0289, Tianjin, Tianjin
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin
Local Institution - 0155, Urumchi, Xinjiang
Xinjiang Medical University Cancer Hospital - Urumqi, Urumqi, Xinjiang
The first Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang
The Second Affiliated hospital of Zhejiang University school of medicine, Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang
Instituto Nacional De Cancerologia, Bogota, Cundinamarca
Fundacion Ctic Centro de Tratamiento E Investigacion Sobre Cancer Luis Carlos Sarmiento Angulo, Bogotá, Distrito Capital De Bogotá
Local Institution - 0390, Zagreb, Grad Zagreb
Local Institution - 0440, Osijek, Not set
Fakultní nemocnice Brno Bohunice, Brno, Brno-město
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové
Fakultni nemocnice Olomouc, Olomouc, Olomoucký Kraj
Fakultni Nemocnice Plzen, Pilsen, Plzeňský Kraj
Fakultni nemocnice Kralovske Vinohrady, PRague, Praha 10
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Local Institution - 0285, Aarhus, Midtjylland
Local Institution - 0284, Odense, Syddanmark
Local Institution - 0281, Oulu, Pohjois-Pohjanmaa
Local Institution - 0283, Kuopio, Pohjois-Savo
Local Institution - 0282, Turku, Varsinais-Suomi
Local Institution - 0280, Helsinki, Not set
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice, Alpes-Maritimes
Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg, Alsace
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux, Aquitaine
Local Institution - 0324, Pessac, Aquitaine
Institut Paoli-Calmettes, Marseille, Bouches-du-Rhône
Local Institution - 0292, Dijon, Côte-d'Or
Chu Jean Minjoz, Besançon, Doubs
CHRU de Brest, Brest, Finistère
Institut Curie - site Saint-Cloud, Saint-Cloud, Hauts-de-Seine
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours, Indre-et-Loire
Chu Grenoble Alpes, La Tronche, Isère
Centre Hospitalier Sud Réunion, Saint-Pierre, La Réunion
Chu Saint Eloi, Montpellier, Languedoc-Roussillon
CHU de Saint-Etienne, Saint Priest en Jarez, Loire
Hôpital Saint Vincent-de-Paul, Lille, Nord-Pas-de-Calais
Hopital Claude Huriez - CHU de Lille, Lille, Nord
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes, Pays-de-la-Loire
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Henri Mondor Hospital, Creteil, Val-de-Marne
Gustave Roussy, Villejuif, Val-de-Marne
Centre Hospitalier Universitaire de Poitiers, Poitiers, Vienne
Centre Hospitalier de la Côte Basque, Bayonne, Not set
Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre, Caen, Not set
Hôpital Saint-Louis, Paris, Not set
Bundeswehrkrankenhaus Ulm, Ulm, Baden-Württemberg
Klinikum Augsburg, Augsburg, Bayern
Klinikum Bayreuth, Bayreuth, Bayern
Universitaetsklinikum Erlangen, Erlangen, Bayern
Gemeinschaftspraxis für Hämatologie und Onkologie, Langen, Hessen
KRH Klinikum Siloah-Oststadt-Heidehaus-Pneumology, Hannover, Niedersachsen
InVO Institut für Versorgungsforschung in der Onkologie, Koblenz, Rheinland-Pfalz
Universitätsklinikum Halle, Halle, Sachsen-Anhalt
Universitätsklinikum Schleswig-Holstein, Lübeck, Schleswig-Holstein
Local Institution - 0508, Berlin, Not set
Medizinische Universität Lausitz- Carl Thiem, Cottbus, Not set
Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf, Dresden, Not set
Universitaetsklinikum Essen, Essen, Not set
Evangelismos General Hospital of Athens, Athens, Attikí
General Hospital of Athens "Laiko", Athens, Attikí
Attikon General University Hospital, Chaidari, Attikí
University Hospital of Alexandroupolis, Alexandroupolis, Not set
University Hospital of Ioannina, Ioannina, Ípeiros
Debreceni Egyetem Klinikai Kozpont, Debrecen, Hajdú-Bihar
Somogy Vármegyei Kaposi Mór Oktató Kórház, Kaposvár, Somogy
Szabolcs Szatmár Bereg Vármegyei Oktatókórház, Nyíregyháza, Szabolcs-Szatmár-Bereg
Markusovszky Egyetemi Oktatokorhaz, Szombathely, Vas
Semmelweis Egyetem, Budapest, Not set
Országos Onkológiai Intézet, Budapest, Not set
All India Institute of Medical Sciences, New Delhi, Delhi
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi
Local Institution - 0429, Srinagar, Jammu And Kashmir
KLES Dr. Prabhakar Kore Hospital & M.R.C, Belagavi, Karnataka
Aster Medcity, Kochi, Kerala
Tata Memorial Hospital, Mumbai, Maharashtra
Narayana Superspecialty Hospital, Howrah, West Bengal
Tata Medical Center, New Town, West Bengal
Ospedale Santa Maria delle Croci, Ravenna, Emilia-Romagna
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma, Lazio
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO, Palermo, Sicilia
Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Not set
Local Institution - 0276, Anjo, Aichi
Nagoya University Hospital, Nagoya, Aichi
National Cancer Center Hospital East, Kashiwa, Chiba
University of Fukui Hospital, Eiheiji-cho,Yoshida-gun, Fukui
Ogaki Municipal Hospital, Ogaki, Gifu
Hokkaido University Hospital, Sapporo, Hokkaido
Aiiku Hospital, Sapporo, Hokkaido
Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyogo
Japanease Red Cross Society Himeji Hospital, Himeji, Hyogo
Ishikawa Prefectural Central Hospital, Kanazawa, Ishikawa
Iwate Prefectural Central Hospital, Morioka, Iwate
Tokai University Hospital, Isehara, Kanagawa
Yokohama Municipal Citizens Hospital, Yokohama, Kanagawa
Tohoku University Hospital, Sendai-shi, Miyagi
Kindai University Hospital- Osakasayama Campus, Osaka-sayama, Osaka
Saitama Medical University International Medical Center, Hidaka, Saitama
Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Shizuoka
Juntendo University Hospital, Bunkyo-ku, Tokyo
Nihon University Itabashi Hospital, Itabashiku, Tokyo
University of Yamanashi Hospital, Chuo, Yamanashi
National Hospital Organization Kyushu Medical Center, Fukuoka, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set
Local Institution - 0215, Kyoto, Not set
Okayama University Hospital, Okayama, Not set
Osaka Red Cross Hospital, Osaka, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Yamagata University Hospital, Yamagata, Not set
National Cancer Center, Goyang-si, Kyǒnggi-do
Local Institution - 0117, Seongnam, Kyǒnggi-do
Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do
Ajou University Hospital, Suwon-si, Kyǒnggi-do
Dong-A University Hospital, Busan, Pusan-Kwangyǒkshi
Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi
Kosin University Gospel Hospital, Busan, Pusan-Kwangyǒkshi
Korea University Anam Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0100, Seoul, Seoul-teukbyeolsi [Seoul]
Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0070, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0442, Daegu, Taegu-Kwangyǒkshi
Kyungpook National University Chilgok Hospital, Deagu, Taegu-Kwangyǒkshi
Local Institution - 0116, Deagu, Taegu-Kwangyǒkshi
Local Institution - 0455, Seongnam, Not set
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Not set
Hospital Pulau Pinang, George Town, Pulau Pinang
Sarawak General Hospital, Kuching, Sarawak
Hospital Ampang, Ampang, Selangor
University Malaya Medical Centre, Lembah Pantai, Wilayah Persekutuan Kuala Lumpur
Health Pharma Professional Research S.A. de C.V:, Ciudad de México, DIF
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, DIF
Local Institution - 0126, Cdmx, Distrito Federal
Local Institution - 0128, México, Distrito Federal
Local Institution - 0448, Guadalajara, Jalisco
Centro de Investigacion Clinica Chapultepec, Morelia, Michoacán
Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Nuevo León
Centro de Investigacion Clinica de Oaxaca, Oaxaca de Juarez, Oaxaca
Local Institution - 0444, Hermosillo, Sonora
Local Institution - 0463, Hermosillo, Sonora
Local Institution - 0123, Huixquilucan, Not set
Unidad Médica Onco-hematológica, Puebla, Not set
Leids Universitair Medisch Centrum, Leiden, Zuid-Holland
University Medical Center Groningen, Groningen, Not set
Dunedin Hospital, Dunedin, Otago
Local Institution - 0366, Hamilton, Waikato
Auckland City Hospital, Auckland, Not set
Local Institution - 0391, Oslo, Not set
Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy, Bydgoszcz, Kujawsko-pomorskie
Centrum Onkologii Ziemi Lubelskiej, Lublin, Lubelskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie, Warszawa, Mazowieckie
Pratia MCM Krakow, Kraków, Małopolskie
Aidport, Skorzewo, Wielkopolskie
Local Institution - 0330, Katowice, Śląskie
Hospital da Luz Lisboa, Lisboa, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Pan American Center for Oncology Trials - Ciudadela, San Juan, Not set
Fundeni Clinical Institute, Bucuresti, București
Local Institution - 0375, Bucuresti, București
Spital Clinic Judetean de Urgenta Tg.Mures, Tg.Mures, Mureș
Sc Onco Card Srl, Brasov, Not set
Affidea Fundeni, București, Not set
Spitalul Clinic Colțea, București, Not set
Spitalul Clinic Colțea, București, Not set
Spitalul Universitar de Urgență București, București, Not set
Institutul Oncologic Cluj, Cluj, Not set
Institutul Regional de Oncologie, Iași, Not set
Spitalul Clinic Județean de Urgență Sibiu, Sibiu, Not set
King Abdulaziz Medical City - National Guard Hospital, Riyadh, Ar Riyāḑ
King Fahad Specialist Hospital - Dammam, Dammam, Ash Sharqīyah
King Abdulaziz Medical City, Jeddah, Not set
King Faisal Specialist Hospital and Research Center, Riyadh, Not set
National Cancer Centre Singapore, Singapore, Central Singapore
Local Institution - 0355, Banska Bystrica, Banskobystrický Kraj
Local Institution - 0204, Bratislava, Not set
CHUAC-Complejo Hospitalario Universitario A Coruña, A Coruña, A Coruña [La Coruña]
Institut Catalan d Oncologia (ICO) - Badalona, Badalona, Barcelona [Barcelona]
Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat, Barcelona [Barcelona]
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, Bizkaia
Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Canarias
Hospital Universitario Donostia, San Sebastian, Gipuzkoa
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Murcia, Región De
Hospital Universitario Virgen de la Victoria, Malaga, Málaga
Hospital San Pedro de Alcantara, Cáceres, Not set
Hospital La Princesa, Madrid, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Local Institution - 0279, Lund, Skåne Län [se-12]
Local Institution - 0487, Solna, Stockholms Län [se-01]
Local Institution - 0277, Uppsala, Uppsala Län [se-03]
Local Institution - 0278, Linköping, Östergötlands Län [se-05]
Chang Gung Memorial Hospital- Chiayi, Chiayi City, Chiayi
Chi Mei Medical Center, Tainan City, Tainan
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set
Chulalongkorn University, Bangkok, Krung Thep Maha Nakhon
Ramathibodi Hospital, Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital, Bangkok, Krung Thep Maha Nakhon
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Not set
Ankara University Health Practice and Research Hospitals, Ankara, Not set
Gazi University Health Research and Application Center Gazi Hospital, Ankara, Not set
Local Institution - 0422, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi, Ankara, Not set
Ege Universitesi Hastanesi, İzmir, Not set
VM Medical Park Mersin Hastanesi, Mersin, Not set
Ondokuz Mayıs Universitesi, Samsun, Not set
Karadeniz Teknik Universitesi Tip Fakultesi, Trabzon, Not set
Conditions: Large B-cell Lymphoma
A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease
Recruiting
The purpose of this study to evaluate the clinical efficacy of guselkumab in fistulizing, perianal Crohn's disease and to assess the overall safety of guselkumab.
The purpose of this study to evaluate the clinical efficacy of guselkumab in fistulizing, perianal Crohn's disease and to assess the overall safety of guselkumab. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +152 locations
University of Alabama at Birmingham, Birmingham, Alabama
Yale University, New Haven, Connecticut
University of Miami, Miami, Florida
Gastroenterology Group Of Naples, Naples, Florida
AdventHealth Medical Group Blood & Marrow Transplant at Orlando, Orlando, Florida
Kansas University Medical Center, Kansas City, Kansas
University of Kentucky Chandler Medical Center, Lexington, Kentucky
University of Louisville, Louisville, Kentucky
Washington University School Of Medicine, Saint Louis, Missouri
Mount Sinai School of Medicine, New York, New York
Digestive Disease Specialists Inc, Oklahoma City, Oklahoma
Gastro One, Germantown, Tennessee
Vanderbilt University Medical Center, Nashville, Tennessee
Tyler Research Institute, LLC, Tyler, Texas
Swedish Medical Center, Seattle, Washington
Flinders Medical Centre, Adelaide, Not set
St Vincent's Hospital - Melbourne, Fitzroy, Not set
Liverpool Hospital, Liverpool, Not set
Fiona Stanley Hospital, Murdoch, Not set
Royal Prince Alfred Hospital, Newtown, Not set
Royal Adelaide Hospital, North Terrace, Not set
Royal Melbourne Hospital, Parkville, Not set
Royal Perth Hospital, Perth, Not set
Mater Hospital, South Brisbane, Not set
Hopital Erasme, Bruxelles, Not set
Ziekenhuis Oost-Limburg, Genk, Not set
UZ Leuven, Leuven, Not set
CHU Sart Tilman, Liege, Not set
University of Alberta- Ziedler Ledcor Centre, Edmonton, Alberta
Nova Scotia Health Authority, Halifax, Nova Scotia
London Health Sciences Centre, London, Ontario
Mount Sinai Hospital, Toronto, Ontario
McGill University Health Centre, Montreal, Quebec
Nemocnice Ceske Budejovice a s, Ceske Budejovice, Not set
ISCARE a.s., Praha 9, Not set
Alexandria University Hospital, Alexandria, Not set
National Hepatology and Tropical Medicine Research Institute, Cairo, Not set
Ain Shams University Hospital, Cairo, Not set
Cairo university, Giza, Not set
Clinique Ambroise Pare, Neuilly-sur-Seine, Not set
CHU de Nice Hopital de l Archet, Nice, Not set
Hopital Saint Joseph, Paris, Not set
Centre Hospitalier Lyon Sud, Pierre-Benite, Not set
CHRU Hopital de Pontchaillou, Rennes, Not set
CHRU Nancy Brabois, Vandoeuvre les Nancy, Not set
Charite - Campus Mitte, Berlin, Not set
JWG-University Hospital, Frankfurt, Not set
Universitatsklinikum Schleswig Holstein Kiel, Kiel, Not set
Universitaetsklinikum Mannheim, Mannheim, Not set
Universitaetsklinikum Ulm, Ulm, Not set
Alexandra General Hospital of Athens, Athens Attica, Not set
Evangelismos General Hospital of Athens, Athens, Not set
Hippokration Hospital, Athens, Not set
Sotiria General State Hospital of Chest Diseases, Athens, Not set
University Hospital of Heraklion, Heraklion, Not set
University Hospital Of Larissa, Larissa, Not set
Patras University Hospital, Patras, Not set
Hippokration Hospital, Thessaloniki, Not set
Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Not set
Semmelweis Egyetem, Budapest, Not set
Semmelweis Egyetem, Budapest, Not set
Semmelweis Egyetem, Budapest, Not set
Pecsi Tudomanyegyetem Orvostudomanyi Es Egeszsegtudomanyi Centrum, I. Belgyogyaszati Klinika, Pecs, Not set
Szegedi Tud Egyetem Szent Gyorgyi Albert Klin Kozp, Szeged, Not set
Haemek Medical Center, Afula, Not set
Rambam Medical Center, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Rabin Medical Center Beilinson Campus, Petah Tikva, Not set
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Not set
Ospedale Classificato Equiparato Sacro Cuore Don Calabria di Negrar, Negrar ( Ve), Not set
Azienda Ospedaliera Universitaria Pisana, Pisa, Not set
Azienda Ospedaliera G.Salvini Ospedale di Rho, RHO, Not set
Policlinico Universitario Agostino Gemelli, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Casa Sollievo della Sofferenza, San Giovanni Rotondo, Not set
KOKIKAI Tokatsu Tsujinaka Hospital, Abiko, Not set
Fukuoka University Chikushi Hospital, Chikushino-shi, Not set
Kitakyushu Municipal Medical Center, Fukuoka-ken, Not set
Fukuoka University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima shi, Not set
Hospital of the University of Occupational and Enviromental Health, Hukuoka, Not set
Sameshima Hospital, Kagoshima, Not set
Nara Medical University Hospital, Kashihara, Not set
Tsujinaka Hospital Kashiwanoha, Kashiwa, Not set
Nagasaki University Hospital, Nagasaki, Not set
Kojunkai Daido Clinic, Nagoya, Not set
Nagoya University Hospital, Nagoya, Not set
The Hospital of Hyogo College of Medicine, Nishinomiya, Not set
Okayama University Hospital, Okayama, Not set
Kinshukai Infusion Clinic, Osaka, Not set
JOHAS Osaka Rosai Hospital, Sakai, Not set
Sapporo Higashi Tokushukai Hospital, Sapporo, Not set
Tokyo Yamate Medical Center, Shinjuku-ku, Not set
Matsuda Hospital, Shizuoka, Not set
Osaka University Hospital, Suita, Not set
Kyorin University Hospital, Tokyo, Not set
Ieda Hospital, Toyota, Not set
Mie University Hospital, Tsu, Not set
Yokkaichi Hazu Medical Center, Yokkaichi, Not set
Yokohama Municipal Citizen's Hospital, Yokohama, Not set
The Speciality Hospital (TSH) / Advanced Clinical Center, Amman, Not set
Jordan University Hospital, Amman, Not set
Abdali Hospital, Amman, Not set
Irbid Specialty Hospital, Irbid, Not set
King Abdullah University Hospital, Irbid, Not set
Inje University Haeundae Paik Hospital, Busan, Not set
Yeungnam University Hospital, Daegu, Not set
Seoul National University Bundang Hospital, Gyeonggi-do, Not set
Seoul National University Hospital, Seoul, Not set
Gangnam Severance Hospital, Yonsei University Health System, Seoul, Not set
Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam, Not set
Radboudumc, Nijmegen, Not set
Erasmus MC, Rotterdam, Not set
UMC Utrecht, Utrecht, Not set
Gastromed Kralisz Romatowski Stachurska Sp. j., Bialystok, Not set
Centrum Medyczne Promed, Krakow, Not set
Centrum Medyczne Med Gastr, Lodz, Not set
Centrum Medyczne Medyk, Rzeszow, Not set
Twoja Przychodnia - Szczecinskie Centrum Medyczne, Szczecin, Not set
GASTROMED Kopon Zmudzinski i wspolnicy SP j Specjalistyczne Centrum Gastrologii i Endoskopii, Torun, Not set
WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Not set
Melita Medical Sp. z o.o., Wroclaw, Not set
Centrum Medyczne Oporow, Wroclaw, Not set
Uls Braga - Hosp. Braga, Braga, Not set
Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos, Lisboa, Not set
H. Santo António - Centro Hospitalar do Porto, Porto, Not set
King Fahad Specialist hospital, Dammam, Not set
King Abdulaziz Medical City, Jeddah, Not set
King Saud University Medical City, Riyadh, Not set
King Faisal Specialist Hospital & Research Center, Riyadh, Not set
Hosp Clinic de Barcelona, Barcelona, Not set
Hosp. Arquitecto Marcide, Ferrol, Not set
Hosp. Univ. Dr. Josep Trueta, Girona, Not set
Hosp. Univ. de La Princesa, Madrid, Not set
Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda, Not set
Hosp. Virgen Macarena, Sevilla, Not set
Hosp. Alvaro Cunqueiro, Vigo, Not set
Hosp. Univ. Miguel Servet, Zaragoza, Not set
Changhua Christian Hospital, Changhua, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei City, Not set
Chang Gung Memorial Hospital Linkou Branch, Taoyuan City, Not set
Gazi University Medical Faculty, Ankara, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Acibadem Kozyatagi Hospital, Istanbul, Not set
Ege University Medical Faculty, İzmir, Not set
Mersin University Medical Faculty Hospital, Mersin, Not set
Hull University Teaching Hospitals NHS Trust, Hull, Not set
London North West University Healthcare NHS Trust, London, Not set
Guys and St Thomas NHS Foundation Trust, London, Not set
St George's University Hospital NHS Foundation Trust, London, Not set
Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, Not set
Pennine Acute Hospitals NHS Trust, Salford, Not set
Conditions: Fistulizing Crohns Disease, Perianal Crohns Disease
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis
Recruiting
The purpose of this study is to evaluate the efficacy and safety of efgartigimod PH20 SC given by a pre-filled syringe in adult patients with ocular myasthenia gravis. The study consists of a part A (approximately 7 weeks) and a part B (up to 2 years). In part A, half of the participants will receive efgartigimod PH20 SC and the other half will receive placebo. In part B, all participants will receive efgartigimod PH20 SC. The participants will be in the study for about up to 2 years and 12 week... Read More
The purpose of this study is to evaluate the efficacy and safety of efgartigimod PH20 SC given by a pre-filled syringe in adult patients with ocular myasthenia gravis. The study consists of a part A (approximately 7 weeks) and a part B (up to 2 years). In part A, half of the participants will receive efgartigimod PH20 SC and the other half will receive placebo. In part B, all participants will receive efgartigimod PH20 SC. The participants will be in the study for about up to 2 years and 12 weeks. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: HonorHealth Neurology - Bob Bové Neuroscience Institute, Scottsdale, Arizona +77 locations
HonorHealth Neurology - Bob Bové Neuroscience Institute, Scottsdale, Arizona
Neurology Offices of South Florida, Boca Raton, Florida
SFM Clinical Research, LLC, Boca Raton, Florida
Neurology Associates PA, Maitland, Florida
University of South Florida, Tampa, Florida
Northwestern Memorial Hospital, Chicago, Illinois
Robert Wood Johnson Medical School, New Brunswick, New Jersey
Duke Neurological Disorders Clinic, Durham, North Carolina
Cleveland Clinic, Cleveland, Ohio
Martha Morehouse Medical plaza, Columbus, Ohio
National Neuromuscular Research Institute, Austin, Texas
Box Hill Hospital, Box Hill, Not set
The Alfred Hospital, Melbourne, Not set
Gold Coast University Hospital, Southport, Not set
Universitätsklinikum AKH Wien, Vienna, Not set
UZ Leuven, Leuven, Not set
Hôpital de la Citadelle, Liège, Not set
Maritime Neurology, Halifax, Not set
Ottawa Hospital Research Institute, Ottawa, Not set
Xiangya Hospital Central South University, Changsha, Not set
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Not set
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Not set
Fujian Medical University Union Hospital, Fuzhou, Not set
Guangdong Province Traditional Chinese Medical Hospital, Guangzhou, Not set
The First Affiliated Hospital of Guangzhou University Chinese Medicine, Guangzhou, Not set
Qilu Hospital of Shandong University, Jinan, Not set
The First Affiliated Hospital of Nanchang University - Xianghu Campus, Nanchang, Not set
Huashan Hospital Fudan University, Shanghai, Not set
Shijiazhuang People's Hospital - Fangbeilu Campus, Shijiazhuang, Not set
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Not set
Renmin Hospital of Wuhan University - Main Campus, Wuhan, Not set
Cyprus Institute of Neurology and Genetics, Egkomi, Not set
Fakultni nemocnice Brno, Brno, Not set
Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice, Pardubice, Not set
Aarhus Universitetshospital, Aarhus N, Not set
Rigshospitalet, København, Not set
Turun Yliopistollinen Keskussairaala, Turku, Not set
Petre Sarajishvili Institute of Neurology, Tbilisi, Not set
New Hospitals, Tbilisi, Not set
Pineo Medical Ecosystem, Tbilisi, Not set
LLC Caucasus Medical Centre, Tbilisi, Not set
Universität Georg August, Göttingen, Not set
Eginitio Hospital, Athens, Not set
University General Hospital of Patras, Patras, Not set
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Not set
Azienda Ospedaliero-Universitaria Sant'Andrea, Roma, Not set
Chiba University Hospital, Chuo-Ku, Not set
Kyushu University Hospital, Fukuoka, Not set
General Hanamaki Hospital, Hanamaki-shi, Not set
Hiroshima University Hospital, Hiroshima, Not set
Saitama Medical Center, Kawagoe, Not set
National Hospital Organization Utano National Hospital, Kyoto-Shi, Not set
IUHW Narita Hospital, Narita, Not set
IUHW Narita Hospital, Narita, Not set
National Hospital Organization Hokkaido Medical Center, Sapporo-Shi, Not set
Tokyo Medical University Hospital, Shinjuku-Ku, Not set
Osaka University Hospital, Suita-Shi, Not set
Kyungpook National University Chilgok hospital, Daegu, Not set
Korea University Anam Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Leids Universitair Medisch Centrum, Leiden, Not set
MICS Centrum Medyczne Bydgoszcz, Bydgoszcz, Not set
Centrum Medyczne Neurologia Slaska, Katowice, Not set
SP ZOZ Szpital Uniwersytecki, Kraków, Not set
Krakowska Akademia Neurologii, Kraków, Not set
CLINIREM Sp z o.o., Lublin, Not set
University Clinical Center of Serbia, Belgrade, Not set
University Clinical Center Nis, Nis, Not set
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Hospital del Mar, Barcelona, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario de Donostia, San Sebastián, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Sahlgrenska Universitetssjukhuset, Göteborg, Not set
Royal Sussex County Hospital, Brighton, Not set
Panthera Biopartners - Glasgow, Glasgow, Not set
Dementech Neurosciences Clinical Academic Centre, London, Not set
Conditions: Myasthenia Gravis, Ocular
A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)
Recruiting
This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is superior to the best available therapy with respect to durable clinicohematologic response (DCHR).
This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is superior to the best available therapy with respect to durable clinicohematologic response (DCHR). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Los Angeles Cancer Network ( Site 3491), Glendale, California +158 locations
Los Angeles Cancer Network ( Site 3491), Glendale, California
Stanford Cancer Institute ( Site 0107), Stanford, California
The Lundquist Institute ( Site 3423), Torrance, California
University of Colorado Anschutz Medical Campus ( Site 3425), Aurora, Colorado
Tufts Medical Center ( Site 3408), Boston, Massachusetts
University of Michigan ( Site 0008), Ann Arbor, Michigan
Henry Ford Hospital ( Site 3413), Detroit, Michigan
Roswell Park Cancer Institute ( Site 3421), Buffalo, New York
Duke University Health System (DUHS) ( Site 0016), Durham, North Carolina
Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 3400), Winston-Salem, North Carolina
Medical University of South Carolina-Hollings Cancer Center ( Site 3426), Charleston, South Carolina
University of Virginia ( Site 3422), Charlottesville, Virginia
VCU Health Adult Outpatient Pavillion ( Site 3416), Richmond, Virginia
Hospital Universitario Austral ( Site 0104), Pilar, Buenos Aires
Hospital Italiano de Buenos Aires ( Site 0105), ABB, Caba
C.I.C.E. 9 de Julio ( Site 1001), San Miguel de Tucumán, Tucuman
Royal Prince Alfred Hospital ( Site 1100), Camperdown, New South Wales
Liverpool Hospital-Haematology ( Site 0501), Liverpool, New South Wales
Royal North Shore Hospital ( Site 0003), St Leonards, New South Wales
Calvary Mater Newcastle ( Site 0505), Waratah, New South Wales
Royal Adelaide Hospital-Haematology Clinical Trials Unit ( Site 0001), Adelaide, South Australia
Monash Health-Haematology Research ( Site 0006), Clayton, Victoria
Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research ( Site 0502), Melbourne, Victoria
Royal Perth Hospital-Haematology ( Site 0504), Perth, Western Australia
ZAS Cadix ( Site 1200), Antwerpen, Not set
The Moncton Hospital-Oncology ( Site 1500), Moncton, New Brunswick
The First Afflilated Hospital of Bengbu Medical College ( Site 3509), Bengbu, Anhui
Anhui Provincial Hospital ( Site 3513), Hefei, Anhui
Peking University Third Hospital-Hematology ( Site 3502), Beijing, Beijing
Peking Union Medical College Hospital ( Site 3531), Beijing, Beijing
The Second Affiliated Hospital Of Fujian Medical University ( Site 3525), Quanzhou, Fujian
The First Affiliated hospital of Xiamen University ( Site 3515), Xiamen, Fujian
Sun Yat-sen Memorial Hospital of Sun Yat-sen University ( Site 3524), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 3511), Guangzhou, Guangdong
The First Hospital of Hebei Medical University ( Site 3510), Shijiazhuang, Hebei
Henan Cancer Hospital-hematology department ( Site 3504), Zhengzhou, Henan
Wuhan Union Hospital ( Site 3500), Wuhan, Hubei
Jiangsu Province Hospital ( Site 3507), Nanjing, Jiangsu
Affiliated Hospital of Nantong University ( Site 3527), Nantong, Jiangsu
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3505), Nanchang, Jiangxi
The First Hospital of Jilin University-Hematology ( Site 3526), Changchun, Jilin
Shaanxi provincial people's hospital ( Site 3516), Xian, Shaanxi
Jinan Central Hospital ( Site 3523), Jinan, Shandong
Zhongshan Hospital,Fudan University-Hematology ( Site 3530), Shanghai, Shanghai
Huashan Hospital, Fudan University ( Site 3529), Shanghai, Shanghai
West China Hospital, Sichuan University ( Site 3518), Cheng Du, Sichuan
Institute of hematology&blood disease hospital ( Site 3501), Tianjin, Tianjin
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3508), Hangzhou, Zhejiang
Zhejiang University School of Medicine-The Fourth Affiliated Hospital ( Site 3517), Yiwu, Zhejiang
Fundacion Colombiana de Cancerología Clinica Vida ( Site 1403), Medellin, Antioquia
IMAT S.A.S ( Site 1401), Monteria, Cordoba
Los Cobos Medical Center ( Site 1404), Bogota, Distrito Capital De Bogota
Hôpital Saint Antoine-Service d'Hématologie et de Thérapie Cellulaire ( Site 1702), Paris, Ile-de-France
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 0417), Rennes, Ille-et-Vilaine
Centre Hospitalier Régional Universitaire de Tours - Hôpital-Hématologie et Thérapie Cellulaire ( Site 0413), Tours, Indre-et-Loire
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuyt-Hématologie Clinique et Thérapie Cellu ( Site 1701), Limoges, Limousin
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois-HEMATOLOGY ( Site 0407), Vandoeuvre lès Nancy, Lorraine
Centre Hospitalier de Roubaix ( Site 1703), Roubaix, Nord
centre hospitalier lyon sud ( Site 0406), Pierre-Bénite, Rhone
Hôpital Saint-Louis-Centre d'Investigations Cliniques ( Site 0405), Paris, Not set
Universitätsklinikum Aachen ( Site 1801), Aachen, Nordrhein-Westfalen
Universitätsklinikum Halle ( Site 0401), Halle, Sachsen-Anhalt
Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 0402), Dresden, Sachsen
Queen Mary Hospital ( Site 1901), Hksar, Not set
Petz Aladar Egyetemi Oktato Korhaz ( Site 2000), Győr, Gyor-Moson-Sopron
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór-Haematológia osztály ( Site 0706), Nyiregyhaza, Szabolcs-Szatmar-Bereg
Semmelweis Egyetem-Belgyógyászati és Hematológiai Klinika ( Site 0708), Budapest, Not set
Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 0707), Debrecen, Not set
Soroka Medical Center ( Site 2100), Be'er Sheva, Not set
Rambam Health Care Campus ( Site 2102), Haifa, Not set
Carmel Hospital ( Site 0906), Haifa, Not set
Hadassah Medical Center ( Site 0904), Jerusalem, Not set
Rabin Medical Center ( Site 0905), Petah Tikva, Not set
Sheba Medical Center ( Site 2101), Ramat Gan, Not set
Sourasky Medical Center ( Site 0902), Tel Aviv, Not set
Yitzhak Shamir Medical Center. ( Site 0901), Zerifin, Not set
Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0034), Alessandria, Ancona
Azienda Ospedaliero Universitaria di Ferrara ( Site 0304), Cona, Ferrara
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0308), Meldola, Forli-Cesena
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 2201), Milano, Lombardia
Azienda Ospedaliera Universitaria Careggi ( Site 0030), Firenze, Toscana
Azienda Ospedaliero Universitaria Pisana-UO Ematologia UNIV ( Site 0309), Pisa, Toscana
Istituto Oncologico Veneto IRCCS-Oncoematologia ( Site 0306), Castelfranco Veneto, Veneto
Azienda Ospedaliero Universitaria delle Marche ( Site 0302), Ancona, Not set
Arcispedale Santa Maria Nuova ( Site 0301), Reggio Emilia, Not set
Ospedale Mauriziano ( Site 0305), Torino, Not set
Ospedale di Circolo e Fondazione Macchi Varese ( Site 2200), Varese, Not set
Fujita Health University Hospital ( Site 3613), Toyoake, Aichi
National Cancer Center Hospital East ( Site 3610), Kashiwa, Chiba
Ehime University Hospital ( Site 3612), Toon, Ehime
Hokkaido University Hospital ( Site 3601), Sapporo, Hokkaido
Kobe City Medical Center General Hospital ( Site 3603), Kobe, Hyogo
Kanazawa University Hospital ( Site 3614), Kanazawa, Ishikawa
Mie University Hospital ( Site 3615), Tsu, Mie
National Hospital Organization Sendai Medical Center ( Site 3617), Sendai, Miyagi
Kansai Medical University Hospital ( Site 3607), Hirakata, Osaka
Kindai University Hospital ( Site 3600), Osakasayama, Osaka
Juntendo University Hospital ( Site 3611), Bunkyo-ku, Tokyo
Nippon Medical School Hospital ( Site 3608), Bunkyo-ku, Tokyo
University of Yamanashi Hospital ( Site 3606), Chuo, Yamanashi
Kyushu University Hospital ( Site 3605), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 3616), Fukushima, Not set
University of Miyazaki Hospital ( Site 3609), Miyazaki, Not set
Okayama University Hospital ( Site 3604), Okayama, Not set
Seoul National University Bundang Hospital-Hematology ( Site 0605), Seongnam, Kyonggi-do
Korea University Anam Hospital ( Site 0604), Seoul, Not set
Asan Medical Center ( Site 0603), Seoul, Not set
The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 0606), Seoul, Not set
Spaarne Gasthuis - Hoofddorp-Oncology ( Site 2301), Hoofddorp, Noord-Holland
Albert Schweitzer Ziekenhuis, locatie Dordwijk-Internal Medicine ( Site 2302), Dordrecht, Zuid-Holland
University Medical Center Groningen ( Site 2304), Groningen, Not set
Martini Ziekenhuis ( Site 2300), Groningen, Not set
North Shore Hospital-Department of Haematology ( Site 0051), Auckland, Not set
Aotearoa Clinical Trials ( Site 0050), Auckland, Not set
Pratia Onkologia Katowice ( Site 0702), Katowice, Slaskie
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S ( Site 2504), Kielce, Swietokrzyskie
Unidade Local de Saude de Braga - Hospital de Braga ( Site 0415), Braga, Not set
Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 2600), Lisboa, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 0414), Porto, Not set
Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 0409), Badalona, Barcelona
Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 2801), L'Hospitalet Del Llobregat, Barcelona
Hospital del Mar ( Site 2807), Barcelona, Cataluna
HOSPITAL CLÍNIC DE BARCELONA ( Site 2800), Barcelona, Cataluna
CHUS - Hospital Clinico Universitario ( Site 0421), Santiago de Compostela, La Coruna
Hospital Universitario Ramón y Cajal-Hematology ( Site 2803), Madrid, Madrid, Comunidad De
Hospital Costa del Sol-Hematology Service ( Site 0412), Marbella, Malaga
Hospital General Universitario de Albacete ( Site 0408), Albacete, Not set
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0404), Barcelona, Not set
Hospital Universitario 12 de Octubre ( Site 2806), Madrid, Not set
Hospital Universitario Virgen de la Victoria ( Site 0418), Malaga, Not set
Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 0419), Salamanca, Not set
Hospital Universitario Doctor Peset ( Site 0411), Valencia, Not set
Universitetssjukhuset Örebro ( Site 0403), Örebro, Orebro Lan
Karolinska Universitetssjukhuset Huddinge ( Site 2900), Huddinge, Stockholms Lan
Chang Gung Memorial Hospital- Chiayi ( Site 3102), Chiayi City, Chiayi
Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 3104), Kaohsiung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 3105), Tainan, Not set
National Taiwan University Hospital ( Site 3101), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch ( Site 3103), Taoyuan, Not set
Hacettepe Universite Hastaneleri-Department of Hematology ( Site 3204), Ankara, Not set
Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 3210), Ankara, Not set
Ankara Bilkent Şehir Hastanesi ( Site 3201), Ankara, Not set
Antalya Egitim ve Arastırma Hastanesi ( Site 3207), Antalya, Not set
Trakya University Medical Faculty Hospital-Hematology ( Site 3200), Edirne, Not set
Medipol Mega Universite Hastanesi-oncology ( Site 3203), Istanbul, Not set
Ege Universitesi Hastanesi ( Site 3202), İzmir, Not set
Kocaeli Üniversitesi-Hematology ( Site 3205), Kocaeli, Not set
VM Medical Park Mersin Hastanesi ( Site 3208), Mersin, Not set
Ondokuz Mayıs Universitesi-hematology ( Site 3206), Samsun, Not set
Addenbrooke's Hospital ( Site 3303), Cambridge, Cambridgeshire
Gloucestershire Royal Hospital ( Site 3302), Gloucester, Gloucestershire
Lincoln County Hospital ( Site 3310), Lincoln, Great Britain
Boston Pilgrim Hospital ( Site 3301), Boston, Lincolnshire
University College London Hospital ( Site 3300), London, London, City Of
Guy's & St Thomas' NHS Foundation Trust ( Site 3305), London, London, City Of
King's College Hospital ( Site 3308), London, London, City Of
Royal Gwent Hospital ( Site 3304), Gwent, Newport
GenesisCare - Windsor ( Site 3309), Windsor, Windsor And Maidenhead
The Christie NHS Foundation Trust ( Site 3307), Manchester, Not set
Conditions: Essential Thrombocythemia
Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial
Recruiting
This phase II trial compares tuvusertib in combination with avelumab to tuvusertib alone to determine whether the combination therapy will lengthen the time before the cancer starts getting worse in patients with Merkel cell cancer that has not responded to previous treatment (refractory). Tuvusertib is a drug that inhibits an enzyme called ataxia telangiectasia and Rad3 related (ATR) kinase, which is an enzyme that plays a role in repair of damaged deoxyribonucleic acid (DNA) as well as tumor c... Read More
This phase II trial compares tuvusertib in combination with avelumab to tuvusertib alone to determine whether the combination therapy will lengthen the time before the cancer starts getting worse in patients with Merkel cell cancer that has not responded to previous treatment (refractory). Tuvusertib is a drug that inhibits an enzyme called ataxia telangiectasia and Rad3 related (ATR) kinase, which is an enzyme that plays a role in repair of damaged deoxyribonucleic acid (DNA) as well as tumor cell replication and survival. It may lead to tumor cell death by inhibiting ATR kinase activity. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving tuvusertib in combination with avelumab may lengthen the time before Merkel cell cancer starts getting worse compared to giving avelumab alone. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California +51 locations
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
UC San Diego Moores Cancer Center, La Jolla, California
Keck Medicine of USC Koreatown, Los Angeles, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
USC Norris Oncology/Hematology-Newport Beach, Newport Beach, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Yale University, New Haven, Connecticut
Sibley Memorial Hospital, Washington, District of Columbia
UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida
UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida
Moffitt Cancer Center - McKinley Campus, Tampa, Florida
Moffitt Cancer Center, Tampa, Florida
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Northwestern University, Chicago, Illinois
Memorial Hospital East, Shiloh, Illinois
HaysMed, Hays, Kansas
University of Kansas Cancer Center, Kansas City, Kansas
Lawrence Memorial Hospital, Lawrence, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
University Health Truman Medical Center, Kansas City, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Wake Forest University Health Sciences, Winston-Salem, North Carolina
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
University Health Network-Princess Margaret Hospital, Toronto, Ontario
Conditions: Locally Advanced Merkel Cell Carcinoma, Metastatic Merkel Cell Carcinoma, Refractory Merkel Cell Carcinoma, Unresectable Merkel Cell Carcinoma, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Recruiting
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease. Read Less
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
08/14/2025
Locations: Imaging Endpoints, Scottsdale, Arizona +125 locations
Imaging Endpoints, Scottsdale, Arizona
Local Institution - 1657, Anaheim, California
Local Institution - 1637, La Jolla, California
Local Institution - 1662, Pomona, California
Local Institution - 1639, Torrance, California
Local Institution - 1651, Walnut Creek, California
Local Institution - 1630, Colorado Springs, Colorado
Local Institution - 1622, Maitland, Florida
Local Institution - 1631, Maitland, Florida
Local Institution - 1618, Miami, Florida
Local Institution - 1609, Miami, Florida
Nuovida Research Center, Miami, Florida
Local Institution - 1608, Ocala, Florida
Local Institution - 1635, Orlando, Florida
Local Institution - 1612, Port Orange, Florida
Local Institution - 1661, Savannah, Georgia
Local Institution - 1655, Marrero, Louisiana
CBH Health, Gaithersburg, Maryland
Local Institution - 1638, Newton, Massachusetts
Local Institution - 1642, South Dartmouth, Massachusetts
Local Institution - 1660, Springfield, Massachusetts
Local Institution - 1620, Troy, Michigan
Local Institution - 1649, Las Vegas, Nevada
Local Institution - 1647, Middletown, New Jersey
Local Institution - 1610, Inwood, New York
Local Institution - 1656, New Windsor, New York
Local Institution - 1645, Woodmere, New York
Local Institution - 1658, Woodmere, New York
Local Institution - 1601, Monroe, North Carolina
Local Institution - 1659, Centerville, Ohio
Central States Research, Tulsa, Oklahoma
Local Institution - 1652, Columbia, South Carolina
Local Institution - 1653, Columbia, South Carolina
Local Institution - 1643, El Paso, Texas
Local Institution - 1641, Salt Lake City, Utah
Local Institution - 1646, Bennington, Vermont
Local Institution - 1644, Seattle, Washington
Local Institution - 1654, Spokane, Washington
Local Institution - 1001, La Plata, Buenos Aires
Local Institution - 1002, Mar del Plata, Buenos Aires
Local Institution - 1006, Rosario, Santa Fe
Local Institution - 1003, Buenos Aires, Not set
Local Institution - 1005, Cordoba, Not set
Local Institution - 1000, Cordoba, Not set
Local Institution - 1004, Córdoba, Not set
Local Institution - 1051, Brasília, Distrito Federal
Local Institution - 1053, Curitiba, Paraná
Local Institution - 1052, Curitiba, Paraná
Local Institution - 1054, Porto Alegre, Rio Grande Do Sul
Local Institution - 1056, Sao Paulo, SP
Local Institution - 1050, Rio De Janeiro, Not set
Local Institution - 1055, São Paulo, Not set
Local Institution - 1100, Sofia, Sofia-Grad
Local Institution - 1101, Pleven, Not set
Local Institution - 1103, Razgrad, Not set
Local Institution - 1102, Varna, Not set
Local Institution - 1153, Hamilton, Ontario
Local Institution - 1151, Toronto, Ontario
Local Institution - 1154, Toronto, Ontario
Local Institution - 1152, Whitby, Ontario
Local Institution - 1150, Montreal, Quebec
Local Institution - 1550, Zagreb, Grad Zagreb
Local Institution - 1553, Zagreb, Grad Zagreb
Local Institution - 1554, Rijeka, Not set
Local Institution - 1551, Split, Not set
Local Institution - 1552, Varazdin, Not set
Local Institution - 1200, Patras, Achaḯa
Local Institution - 1205, Athens, Attiki
Local Institution - 1202, Athens, Attiki
Local Institution - 1206, Athens, Not set
Local Institution - 1203, Athens, Not set
Local Institution - 1207, Athens, Not set
Local Institution - 1201, Ioannina, Not set
Local Institution - 1204, Thessaloniki, Not set
Local Institution - 1251, Hyderabad, Andhra Pradesh
Local Institution - 1255, Ahmedabad, Gujarat
Local Institution - 1252, Hyderabad, Telangana
Local Institution - 1254, Varanasi, Uttar Pradesh
Local Institution - 1250, Kolkata, West Bengal
Local Institution - 1256, Delhi, Not set
Local Institution - 1253, New Delhi, Not set
Local Institution - 1301, Hadano, Kanagawa
Local Institution - 1307, Kawasaki, Kanagawa
Local Institution - 1304, Sakai, Osaka
Local Institution - 1300, Karatsu-shi, Saga-Ken
Local Institution - 1303, Kanzaki-Gun Yoshinogari-Cho, Saga
Local Institution - 1305, Bunkyo-ku, Tokyo
Local Institution - 1302, Fukuoka, Not set
Local Institution - 1306, Okayama, Not set
Local Institution - 1355, Saltillo, Coahuila
Local Institution - 1356, Ciudad de México, Distrito Federal
Local Institution - 1350, Monterrey, Nuevo León
Local Institution - 1361, Mexico City, Not set
Local Institution - 1363, Mexico City, Not set
Local Institution - 1360, Mexico City, Not set
Local Institution - 1362, San Luis Potosi, Not set
Local Institution - 1352, Tlalnepantla de Baz, Not set
Local Institution - 1401, Coimbra, Not set
Local Institution - 1402, Guimaraes, Not set
Local Institution - 1404, Lisboa, Not set
Local Institution - 1403, Senhora da Hora, Not set
Local Institution - 1400, Torres Vedras, Not set
Local Institution - 1459, Bucharest, București
Local Institution - 1450, Bucuresti, București
Local Institution - 1452, Bucuresti, București
Local Institution - 1453, Bucuresti, București
Local Institution - 1454, Bucuresti, București
Local Institution - 1455, Bucuresti, București
Local Institution - 1456, Bucuresti, București
Local Institution - 1458, Bucuresti, București
Local Institution - 1451, Bucuresti, Not set
Local Institution - 1461, Constanta, Not set
Local Institution - 1457, Iasi, Not set
Local Institution - 1460, Sanpetru /Brasov, Not set
Local Institution - 1462, Sibiu, Not set
Local Institution - 1510, Getxo, Bizkaia
Local Institution - 1509, Elche (alicante), Not set
Local Institution - 1508, Madrid, Not set
Local Institution - 1505, Madrid, Not set
Local Institution - 1502, Malaga, Not set
Local Institution - 1507, Pamplona, Not set
Local Institution - 1500, Salamanca, Not set
Local Institution - 1503, Sevilla, Not set
Local Institution - 1504, Terrassa, Not set
Local Institution - 1506, Valladolid, Not set
Local Institution - 1501, Zaragoza, Not set
Conditions: Alzheimer Disease
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