All Clinical Trials in Canada

A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

NCT05923073

Recruiting

The purpose of this study is to evaluate the clinical and endoscopic efficacy of guselkumab in pediatric participants with Crohn's Disease (CD) at the end of maintenance therapy (Week 52) among participants who were in clinical response to guselkumab at Week 12.

Gender:

ALL

Ages:

Between 2 years and 17 years

Trial Updated:

08/14/2025

Locations: Connecticut Children's Medical Center, Hartford, Connecticut +68 locations

Connecticut Children's Medical Center, Hartford, Connecticut

Emory University, Atlanta, Georgia

Children's Center for Digestive Health Care, Atlanta, Georgia

Riley Hospital for Children, Indianapolis, Indiana

Weill Cornell Medical College - Judith Jaffe Multiple Sclerosis Center, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Medical Center, New York, New York

The Children's Medical Center of Dayton, Dayton, Ohio

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Cook Childrens Medical Center, Fort Worth, Texas

University of Vermont Medical Center, Colchester, Vermont

AKH - Medizinische Universitat Wien, Vienna, Not set

Universitair Ziekenhuis Brussel, Brussels, Not set

Cliniques Universitaires Saint Luc, Bruxelles, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Sociedade Campineira de Educacao e Instrucao Hospital e Maternidade Celso Pierro, Campinas, Not set

Associacao Hospitalar de Protecao a Infancia Dr. Raul Carneiro, Curitiba, Not set

Universidade Federal de Goias - Hospital das Clinicas da UFG, Goiania, Not set

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set

Centro de Ciências e Saúde da Universidade Federal do Espirito Santo-Núcleo de Doenças Infecciosas, Vitória, Not set

INTEGRAL Pesquisa e Ensino, Votuporanga, Not set

Iwk Health Centre, Halifax, Nova Scotia

CHU Amiens-Hopital Nord, Amiens Cedex 1, Not set

Hôpital Jeanne de FLANDRE, CHRU LILLE, Lille, Not set

Hôpital Necker - Enfants Malades, Paris cedex 15, Not set

Hôpital Robert Debré, Paris, Not set

Shamir Medical Center Assaf Harofeh, Be Er Ya Akov, Not set

Soroka University Medical Center, Beersheba, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Hadassah Medical Center, Jerusalem, Not set

Schneider Children's Medical Center, Petach-Tikva, Not set

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII), Bergamo, Not set

Ospedale Bellaria, U.O.Cardiologia Az. USL di Bologna, Bologna, Not set

Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer, Firenze, Not set

Azienda Socio Sanitaria Territoriale Fatebenefratelli Presidio Ospedale dei Bambini Vittore Buzzi, Milano, Not set

AOU Policlinico Umberto I, Roma, Not set

Hirosaki University Hospital, Hirosaki, Not set

Tsujinaka Hospital Kashiwanoha, Kashiwa-shi, Not set

Kobe University Hospital, Kobe, Not set

Saga University Hospital, Saga, Not set

Miyagi Children's Hospital, Sendai, Not set

National Center for Child Health and Development, Setagaya Ku, Not set

Juntendo University Hospital, Tokyo, Not set

Yokohama City University Medical Center, Yokohama-shi, Not set

Inje University Haeundae Paik Hospital, Busan, Not set

Kyungpook National University Chilgok Hospital, Daegu, Not set

Seoul National University Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

Erasmus Medisch Centrum, Rotterdam, Not set

Akershus Universitetssykehus HF, Nordbyhagen, Not set

Oslo University Hospital, Oslo, Not set

Universitetssykehuset Nord-Norge HF, Tromsø, Not set

St. Olavs Hospital, Trondheim, Not set

Korczowski Bartosz Gabinet Lekarski, Rzeszow, Not set

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Instytut Pomnik Centrum Zdrowia, Warszawa, Not set

Hospital de Braga, Braga, Not set

Centro Hospitalar de Lisboa Norte Hospital Santa Maria, Lisboa, Not set

Centro Hospitalar de Sao Joao E.P.E., Porto, Not set

Hosp Reina Sofia, Córdoba, Not set

Corporacio Sanitari Parc Tauli, Sabadell, Not set

Hosp. Univ. I Politecni La Fe, Valencia, Not set

Royal Hospital for Sick Children, Glasgow, Not set

Great Ormond Street Hospital, London, Not set

Nowgen Centre, Research and Innovation, Manchester, Not set

Royal Manchester Children's Hospital, Manchester, Not set

John Radcliffe Hospital, Oxford, Not set

Sheffield Children's Hospital, Sheffield, Not set

Conditions: Crohn's Disease

Learn More ›

Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD)

NCT05113641

Recruiting

Metabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well. This can be associated with a higher risk of worsening kidney function and death. The usual treatment is a medication called sodium bicarbonate which works to balance the acids in the body. The medication however often does not work and causes side effects. Consumption of alkalizing fruit and vegetables may work as a treatment for metabolic ac... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: Seven Oaks General Hospital Chronic Disease Innovation Centre, Winnipeg, Manitoba +2 locations

Conditions: Chronic Kidney Diseases, Metabolic Acidosis

Learn More ›

Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma

NCT05180097

Recruiting

This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: Concord Repatriation General Hospital, Concord, New South Wales +17 locations

Conditions: Hodgkin Lymphoma

Learn More ›

A Study to Learn More About the Effects and Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old

NCT06953583

Recruiting

In this study, researchers will learn more about the effects and safety of BIIB141, also known as omaveloxolone or SKYCLARYS®. This drug has been approved, or made available for doctors to prescribe, for people with Friedreich's Ataxia (FA) who are at least 16 years old. But, it is not yet available for children and teens with FA who are younger than 16 years old. The main objective of this study is to learn how BIIB141 works in the body and about its safety in children and teens who are 2 to 15 years old. The main questions researchers want to answer in this study are: * How does BIIB141 affect the participants' FA symptoms balance and stability? * How many participants have medical problems during the study? * Are there any changes in the participants' overall health during the study? * Are there any changes in the participants' heart health? * Are there any changes in how the participants move through puberty? Puberty is the time in someone's life when their body changes from a child to an adult. Researchers will also learn more about: - How the body processes BIIB141 in children and teens This study will be done as follows: * Participants will be screened to check if they can join the study. The screening period will be up to 28 days, after which participants will check into their study research center. * There are 2 parts in this study. During Part 1, participants will take either BIIB141 or a placebo once a day. * In Part 1, participants will take BIIB141 or the placebo in a study research center on Day 1, and then at in-person visits at Week 4, Week 12, Week 26, and Week 52. On all other days, they will take BIIB141 or the placebo at home. Part 1 lasts up to 52 weeks. * During Part 2, participants from Part 1 will either continue taking BIIB141 or start it if they were taking the placebo. Part 2 will last up to 104 weeks. * In Part 1, participants will have up to 10 visits to their study research center and a phone call at Week 2. In Part 2, participants will have visits at Weeks 4, 8,12, 26, and every 26 weeks after that until they leave the study, and a phone call at Week 2. There will be a final phone call to check on the participants' health 31 days after their last dose. * Each participant will be in the study for up to about 3 years Read Less

Gender:

ALL

Ages:

Between 2 years and 15 years

Trial Updated:

08/14/2025

Locations: UCLA Neurology Outpatient Clinic at Westwood, Los Angeles, California +26 locations

UCLA Neurology Outpatient Clinic at Westwood, Los Angeles, California

Norman Fixel Institute for Neurological Diseases UF Health, Gainesville, Florida

USF Health Morsani College of Medicine Department of Neurology, Tampa, Florida

Children's Hospital of Philadelphia Buerger Center, Philadelphia, Pennsylvania

St Jude Children's Research Hospital, Memphis, Tennessee

Children's Hospital of the King's Daughters, Norfolk, Virginia

Murdoch Childrens Research Institute (MCRI), Parkville, Victoria

Universitätsklinikum Innsbruck, Innsbruck, Not set

L2 Ip - Instituto de Pesquisas Clinicas Ltda - ME, Brasília, Distrito Federal

University of Campinas (UNICAMP) School of Medical Sciences, Campinas, Sao Paulo

PSEG Centro de Pesquisa Clinica, Sao Paulo, Not set

McGill University, Montreal, Quebec

Rigshospitalet - Juliane Marie Centret (JMC) Copenhagen, Copenhagen, Not set

CHU de Montpellier - Hôpital Arnaud de Villeneuve, Montpellier, Hérault

AP-HP - Hôpital Armand Trousseau, Paris, Not set

Universitätsklinikum Aachen, Aachen, Not set

UKGM - Universitätsklinikum Giessen und Marburg GmbH - Standort Gießen, Giessen, Not set

UKE Hamburg, Hamburg, Not set

CHI at Temple Street, Dublin, Not set

Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Lazio

IRCCS Eugenio Medea - Polo. Scientifico Veneto, Conegliano, Veneto

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Not set

Radboud Universitair Medisch Centrum, Nijmegen, Not set

Hospital Sant Joan de Deu, Espluges De Llobregat, Not set

Hospital Universitario La Paz - PPDS, Madrid, Not set

Sheffield Children's Hospital, Sheffield, South Yorkshire

University College London, Institue of Neurology, London, Not set

Conditions: Friedreich Ataxia

Learn More ›

Sex Differences in Metabolism Following a High-fat Meal

NCT05332301

Recruiting

Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (\>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2 diabetes. Women tend to be better protected against the development of high-fat diet-induced insulin resistance compared with men, but it is not fully understand why this sex difference exists. It is possible that women metabolize high-fat meals differently than men, which m... Read More

Gender:

ALL

Ages:

Between 18 years and 35 years

Trial Updated:

08/14/2025

Locations: McMaster University, Hamilton, Ontario

Conditions: Healthy Nutrition

Learn More ›

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

NCT06465186

Recruiting

Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat MASH.The goals of this study are to learn: * If efinopegdutide can lower the amount of fat, inflammation, and scarring (fibrosis) in the liver * About the safety of efinopegdutide and how well peopl... Read More

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

08/14/2025

Locations: The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149), Chandler, Arizona +64 locations

The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149), Chandler, Arizona

Arizona Clinical Trials ( Site 0158), Flagstaff, Arizona

The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0120), Peoria, Arizona

The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 0111), Tucson, Arizona

California Liver Research Institute ( Site 0113), Pasadena, California

Acclaim Clinical Research ( Site 0137), San Diego, California

Velocity Clinical Research, Panorama City ( Site 0124), Van Nuys, California

Rocky Mountain Gastroenterology ( Site 0127), Littleton, Colorado

Synergy Healthcare ( Site 0118), Bradenton, Florida

Homestead Associates in Research, Inc. ( Site 0139), Homestead, Florida

Florida Research Institute ( Site 0116), Lakewood Ranch, Florida

Floridian Clinical Research, LLC ( Site 0109), Miami Lakes, Florida

Southeast Clinical Research Center ( Site 0119), Dalton, Georgia

Delta Research Partners ( Site 0160), Bastrop, Louisiana

Louisiana Research Center ( Site 0161), Shreveport, Louisiana

Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 0130), Glen Burnie, Maryland

Velocity Clinical Research Rockville ( Site 0143), Rockville, Maryland

Huron Gastroenterology ( Site 0102), Ypsilanti, Michigan

The Machuca Foundation ( Site 0115), Las Vegas, Nevada

Excel Clinical Research, LLC ( Site 0101), Las Vegas, Nevada

Southwest Gastroenterology Associates ( Site 0129), Albuquerque, New Mexico

Coastal Research Institute - Fayetteville ( Site 0159), Fayetteville, North Carolina

Lucas Research, Inc ( Site 0105), Morehead City, North Carolina

Texas Clinical Research Institute ( Site 0126), Arlington, Texas

Pinnacle Clinical Research ( Site 0104), Austin, Texas

Pinnacle Clinical Research-Corpus Christi ( Site 0156), Corpus Christi, Texas

Zenos Clinical Research ( Site 0136), Dallas, Texas

GI Alliance Department of Research ( Site 0162), Fort Worth, Texas

Houston Research Institute ( Site 0172), Houston, Texas

Houston Research Institute ( Site 0117), Houston, Texas

American Research Corporation ( Site 0131), San Antonio, Texas

Pinnacle Clinical Research-Clinical Research Coordination ( Site 0125), San Antonio, Texas

Flinders Medical Centre-Hepatology and Liver Transplant Medicine ( Site 1202), Adelaide, South Australia

St Vincent's Hospital-Gastroenterology Department ( Site 1205), Melbourne, Victoria

Toronto General Hospital ( Site 0207), Toronto, Ontario

Diex Recherche Quebec ( Site 0204), Quebec, Not set

Fundacion Santa Fe de Bogota ( Site 0403), Bogotá, Cundinamarca

Fundación Valle del Lili ( Site 0402), Cali, Valle Del Cauca

CHU Bordeaux Haut-Leveque-Service d'Hépato-gastroentérologie ( Site 0701), Pessac, Aquitaine

Hôpital Beaujon-Hépatologie ( Site 0703), Clichy, Hauts-de-Seine

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren-Hépato-gastroentérologie ( Site 0702), Limoges, Limousin

Hôpital de la Croix Rousse-Centre de Recherche Clinique ( Site 0705), Lyon, Rhone-Alpes

Rambam Health Care Campus ( Site 0801), Haifa, Not set

Carmel Hospital-Liver Unit ( Site 0802), Haifa, Not set

Shaare Zedek Medical Center ( Site 0805), Jerusalem, Not set

Maccabi Health Services - Petah Tikva ( Site 0804), Petah Tikva, Not set

Shinyurigaoka General Hospital ( Site 1401), Kawasaki, Kanagawa

Yokohama City University Hospital ( Site 1402), Yokohama, Kanagawa

University Hospital,Kyoto Prefectural University of Medicine ( Site 1404), Kyoto, Not set

Osaka Metropolitan University Hospital ( Site 1403), Osaka, Not set

Saga University Hospital ( Site 1405), Saga, Not set

ISIS CLINICAL RESEARCH CENTER ( Site 0606), Guaynabo, Not set

Klinical Investigations Group-Clinical Research ( Site 0601), San Juan, Not set

Hospital Universitario Marqués de Valdecilla-Gastroenterology and Hepatology ( Site 1004), Santander, Cantabria

Hospital Clínico Universitario de Valladolid-Servicio de Endocrinologia y Nutricion ( Site 1008), Valladolid, Castilla Y Leon

Hospital General de Tomelloso-Aparato Digestivo ( Site 1006), Tomelloso, Ciudad Real

CHUAC-Complejo Hospitalario Universitario A Coruña-Endocrinología ( Site 1007), A Coruña, La Coruna

CHUS - Hospital Clinico Universitario ( Site 1011), Santiago de Compostela, La Coruna

Hospital Universitari Vall d'Hebron-Liver Unit - Department of Internal Medicine ( Site 1002), Barcelona, Not set

Hospital Universitario La Paz-HEPATOLOGIA ( Site 1005), Madrid, Not set

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Unidad de Ensayos clinicos de Aparato Digestivo ( Site 1001), Sevilla, Not set

Chulalongkorn University ( Site 1301), Bangkok, Krung Thep Maha Nakhon

Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 1302), Bangkok, Krung Thep Maha Nakhon

King's College Hospital ( Site 1104), London, London, City Of

Aberdeen Royal Infirmary-Department of Gastroenterology ( Site 1102), Aberdeen, Scotland

Conditions: Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, NAFLD, Metabolic Dysfunction-associated Steatotic Liver Disease, Metabolic Dysfunction-associated Steatohepatitis

Learn More ›

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

NCT06401330

Recruiting

This phase III trial studies using risk factors in determining treatment for children with favorable tissue (histology) Wilms tumors (FHWT). Wilms Tumor is the most common type of kidney cancer in children, and FHWT is the most common subtype. Previous large clinical trials have established treatment plans that are likely to cure most children with FHWT, however some children still have their cancer come back (called relapse) and not all survive. Previous research has identified features of FHWT... Read More

Gender:

ALL

Ages:

30 years and below

Trial Updated:

08/14/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +89 locations

Children's Hospital of Alabama, Birmingham, Alabama

Providence Alaska Medical Center, Anchorage, Alaska

Banner Children's at Desert, Mesa, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

Loma Linda University Medical Center, Loma Linda, California

Cedars Sinai Medical Center, Los Angeles, California

Kaiser Permanente-Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

Rady Children's Hospital - San Diego, San Diego, California

Children's Hospital Colorado, Aurora, Colorado

Alfred I duPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington, District of Columbia

Broward Health Medical Center, Fort Lauderdale, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Nemours Children's Hospital, Orlando, Florida

Nemours Children's Clinic - Pensacola, Pensacola, Florida

Saint Mary's Medical Center, West Palm Beach, Florida

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Riley Hospital for Children, Indianapolis, Indiana

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Children's Hospital New Orleans, New Orleans, Louisiana

Maine Children's Cancer Program, Scarborough, Maine

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Dana-Farber Cancer Institute, Boston, Massachusetts

UMass Memorial Medical Center - University Campus, Worcester, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

Children's Hospital of Michigan, Detroit, Michigan

Mayo Clinic in Rochester, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Cardinal Glennon Children's Medical Center, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Jersey Shore Medical Center, Neptune, New Jersey

Saint Peter's University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Albany Medical Center, Albany, New York

Roswell Park Cancer Institute, Buffalo, New York

NYU Langone Hospital - Long Island, Mineola, New York

Stony Brook University Medical Center, Stony Brook, New York

State University of New York Upstate Medical University, Syracuse, New York

New York Medical College, Valhalla, New York

East Carolina University, Greenville, North Carolina

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Dayton Children's Hospital, Dayton, Ohio

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Legacy Emanuel Children's Hospital, Portland, Oregon

Geisinger Medical Center, Danville, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Prisma Health Richland Hospital, Columbia, South Carolina

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

East Tennessee Childrens Hospital, Knoxville, Tennessee

Saint Jude Children's Research Hospital, Memphis, Tennessee

Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas

Dell Children's Medical Center of Central Texas, Austin, Texas

Medical City Dallas Hospital, Dallas, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

UMC Cancer Center / UMC Health System, Lubbock, Texas

Children's Hospital of San Antonio, San Antonio, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

Primary Children's Hospital, Salt Lake City, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

Children's Hospital of The King's Daughters, Norfolk, Virginia

VCU Massey Comprehensive Cancer Center, Richmond, Virginia

Carilion Children's, Roanoke, Virginia

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin

IWK Health Centre, Halifax, Nova Scotia

Conditions: Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor, Stage III Mixed Cell Type Kidney Wilms Tumor, Stage IV Mixed Cell Type Kidney Wilms Tumor

Learn More ›

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

NCT05208762

Recruiting

This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable). This study will have five parts. Parts A and B of the study will find out how much PF-0804605... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +46 locations

University of Alabama at Birmingham, Birmingham, Alabama

University of Alabama at Birmingham, IDS Pharmacy, Birmingham, Alabama

University of Alabama at Birmingham, Birmingham, Alabama

University of California Davis Comprehensive Cancer Center, Sacramento, California

University of California, Davis Medical Center, Sacramento, California

University of Iowa Hospitals & Clinics, Iowa City, Iowa

Karmanos Cancer Institute, Detroit, Michigan

Karmanos Cancer Institute, Farmington Hills, Michigan

University Hospitals Cleveland Medical Center, Cleveland, Ohio

The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services, Houston, Texas

The University of Texas MD Anderson Cancer Center, Houston, Texas

South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas

START Mountain Region, West Valley City, Utah

NEXT Virginia, Fairfax, Virginia

Institut Jules Bordet, Anderlecht, Not set

University Health Network, Princess Margaret Hospital, Toronto, Ontario

McGill University Health Centre, Montreal, Quebec

Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing

Beijing Cancer Hospital, Beijing, Beijing

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei

Shanghai East Hospital, Shanghai, Shanghai

Hôpital Saint André - CHU Bordeaux, BORDEAUX Cedex, Not set

Clinique Ambroise Pare, Neuilly sur seine, Not set

Institut Curie, Paris Cedex 05, Not set

lnstitut Curie Pharmacy, Paris, Not set

Gustave Roussy Institute - Service pharmacie, Villejuif, Not set

Charite Universitatsmedizin Berlin, Berlin, Not set

Apotheke-Zytostatika Studien Charite- Universitatsmedizin Berlin Campus Virchow Klinkum, Berlin, Not set

Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative lstituto Europeo di Oncologia, Milano, Milan

Centro Ricerche Cliniche di Verona s.r.l. c/o Policlinico G.B Rossi, Verona, Other

Azienda Ospedaliera Universitaria Integrata Verona - Policlinico G.B Rossi, Verona, Veneto

UOC Oncologia - IRCCS Azienda Ospedaliero Universitaria Bologna, Bologna, Not set

National Cancer Center Hospital East, Kashiwa, Chiba

Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka

The Netherlands Cancer Institute, Amsterdam, Not set

CETIR Viladomat, Barcelona, Other

Hospital Duran I Reynals-Institut Català d'Oncologia L'Hospitalet (ICO L'Hospitalet), Barcelona, Other

Hospital Quiron Salud Barcelona, Barcelona, Not set

NEXT Oncology Barcelona - IOB - Hospital Quironsalud Barcelona, Barcelona, Not set

Hospital Universitari Vall d'Hebron, Barcelona, Not set

START Madrid - CIOCC - Hospital Universitario HM Sanchinarro, Madrid, Not set

Diagnostic Centre, London, Others

The Harley Street Clinic (THSC), London, Other

Pharmacy: Royal Marsden Hospital, Sutton, Surrey

Royal Marsden Hospital, Sutton, Surrey

Sarah Cannon Research Institute, London, Not set

Radiology, London, Not set

Conditions: Carcinoma, Non-Small-Cell Lung, Squamous Cell Carcinoma of the Head and Neck, Esophageal Squamous Cell Carcinoma, Ovarian Neoplasms, Melanoma, Triple Negative Breast Neoplasms, Gastric Cancer

Learn More ›

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

NCT07011732

Recruiting

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.

Gender:

ALL

Ages:

Between 55 years and 90 years

Trial Updated:

08/14/2025

Locations: Imaging Endpoints, Scottsdale, Arizona +125 locations

Imaging Endpoints, Scottsdale, Arizona

Local Institution - 1657, Anaheim, California

Local Institution - 1637, La Jolla, California

Local Institution - 1662, Pomona, California

Local Institution - 1639, Torrance, California

Local Institution - 1651, Walnut Creek, California

Local Institution - 1630, Colorado Springs, Colorado

Local Institution - 1622, Maitland, Florida

Local Institution - 1631, Maitland, Florida

Local Institution - 1618, Miami, Florida

Local Institution - 1609, Miami, Florida

Nuovida Research Center, Miami, Florida

Local Institution - 1608, Ocala, Florida

Local Institution - 1635, Orlando, Florida

Local Institution - 1612, Port Orange, Florida

Local Institution - 1661, Savannah, Georgia

Local Institution - 1655, Marrero, Louisiana

CBH Health, Gaithersburg, Maryland

Local Institution - 1638, Newton, Massachusetts

Local Institution - 1642, South Dartmouth, Massachusetts

Local Institution - 1660, Springfield, Massachusetts

Local Institution - 1620, Troy, Michigan

Local Institution - 1649, Las Vegas, Nevada

Local Institution - 1647, Middletown, New Jersey

Local Institution - 1610, Inwood, New York

Local Institution - 1656, New Windsor, New York

Local Institution - 1645, Woodmere, New York

Local Institution - 1658, Woodmere, New York

Local Institution - 1601, Monroe, North Carolina

Local Institution - 1659, Centerville, Ohio

Central States Research, Tulsa, Oklahoma

Local Institution - 1652, Columbia, South Carolina

Local Institution - 1653, Columbia, South Carolina

Local Institution - 1643, El Paso, Texas

Local Institution - 1641, Salt Lake City, Utah

Local Institution - 1646, Bennington, Vermont

Local Institution - 1644, Seattle, Washington

Local Institution - 1654, Spokane, Washington

Local Institution - 1001, La Plata, Buenos Aires

Local Institution - 1002, Mar del Plata, Buenos Aires

Local Institution - 1006, Rosario, Santa Fe

Local Institution - 1003, Buenos Aires, Not set

Local Institution - 1005, Cordoba, Not set

Local Institution - 1000, Cordoba, Not set

Local Institution - 1004, Córdoba, Not set

Local Institution - 1051, Brasília, Distrito Federal

Local Institution - 1053, Curitiba, Paraná

Local Institution - 1052, Curitiba, Paraná

Local Institution - 1054, Porto Alegre, Rio Grande Do Sul

Local Institution - 1056, Sao Paulo, SP

Local Institution - 1050, Rio De Janeiro, Not set

Local Institution - 1055, São Paulo, Not set

Local Institution - 1100, Sofia, Sofia-Grad

Local Institution - 1101, Pleven, Not set

Local Institution - 1103, Razgrad, Not set

Local Institution - 1102, Varna, Not set

Local Institution - 1153, Hamilton, Ontario

Local Institution - 1151, Toronto, Ontario

Local Institution - 1154, Toronto, Ontario

Local Institution - 1152, Whitby, Ontario

Local Institution - 1150, Montreal, Quebec

Local Institution - 1550, Zagreb, Grad Zagreb

Local Institution - 1553, Zagreb, Grad Zagreb

Local Institution - 1554, Rijeka, Not set

Local Institution - 1551, Split, Not set

Local Institution - 1552, Varazdin, Not set

Local Institution - 1200, Patras, Achaḯa

Local Institution - 1205, Athens, Attiki

Local Institution - 1202, Athens, Attiki

Local Institution - 1206, Athens, Not set

Local Institution - 1203, Athens, Not set

Local Institution - 1207, Athens, Not set

Local Institution - 1201, Ioannina, Not set

Local Institution - 1204, Thessaloniki, Not set

Local Institution - 1251, Hyderabad, Andhra Pradesh

Local Institution - 1255, Ahmedabad, Gujarat

Local Institution - 1252, Hyderabad, Telangana

Local Institution - 1254, Varanasi, Uttar Pradesh

Local Institution - 1250, Kolkata, West Bengal

Local Institution - 1256, Delhi, Not set

Local Institution - 1253, New Delhi, Not set

Local Institution - 1301, Hadano, Kanagawa

Local Institution - 1307, Kawasaki, Kanagawa

Local Institution - 1304, Sakai, Osaka

Local Institution - 1300, Karatsu-shi, Saga-Ken

Local Institution - 1303, Kanzaki-Gun Yoshinogari-Cho, Saga

Local Institution - 1305, Bunkyo-ku, Tokyo

Local Institution - 1302, Fukuoka, Not set

Local Institution - 1306, Okayama, Not set

Local Institution - 1355, Saltillo, Coahuila

Local Institution - 1356, Ciudad de México, Distrito Federal

Local Institution - 1350, Monterrey, Nuevo León

Local Institution - 1361, Mexico City, Not set

Local Institution - 1363, Mexico City, Not set

Local Institution - 1360, Mexico City, Not set

Local Institution - 1362, San Luis Potosi, Not set

Local Institution - 1352, Tlalnepantla de Baz, Not set

Local Institution - 1401, Coimbra, Not set

Local Institution - 1402, Guimaraes, Not set

Local Institution - 1404, Lisboa, Not set

Local Institution - 1403, Senhora da Hora, Not set

Local Institution - 1400, Torres Vedras, Not set

Local Institution - 1459, Bucharest, București

Local Institution - 1450, Bucuresti, București

Local Institution - 1452, Bucuresti, București

Local Institution - 1453, Bucuresti, București

Local Institution - 1454, Bucuresti, București

Local Institution - 1455, Bucuresti, București

Local Institution - 1456, Bucuresti, București

Local Institution - 1458, Bucuresti, București

Local Institution - 1451, Bucuresti, Not set

Local Institution - 1461, Constanta, Not set

Local Institution - 1457, Iasi, Not set

Local Institution - 1460, Sanpetru /Brasov, Not set

Local Institution - 1462, Sibiu, Not set

Local Institution - 1510, Getxo, Bizkaia

Local Institution - 1509, Elche (alicante), Not set

Local Institution - 1508, Madrid, Not set

Local Institution - 1505, Madrid, Not set

Local Institution - 1502, Malaga, Not set

Local Institution - 1507, Pamplona, Not set

Local Institution - 1500, Salamanca, Not set

Local Institution - 1503, Sevilla, Not set

Local Institution - 1504, Terrassa, Not set

Local Institution - 1506, Valladolid, Not set

Local Institution - 1501, Zaragoza, Not set

Conditions: Alzheimer Disease

Learn More ›

A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy

NCT05808764

Recruiting

This study will evaluate the pharmacokinetics (PK) and safety of risdiplam in participants with spinal muscular atrophy (SMA) under 20 days of age at first dose.

Gender:

ALL

Ages:

19 days and below

Trial Updated:

08/14/2025

Locations: Ann and Robert H. Lurie Children Hospital of Chicago, Chicago, Illinois +12 locations

Conditions: Muscular Atrophy, Spinal

Learn More ›

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

NCT05156281

Recruiting

To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis (RMS)

Gender:

ALL

Ages:

Between 18 years and 55 years

Trial Updated:

08/14/2025

Locations: Ctr for Neurology and Spine, Phoenix, Arizona +240 locations

Ctr for Neurology and Spine, Phoenix, Arizona

Vladimir Royter MD APMC, Hanford, California

VA Greater LA Healthcare System, Los Angeles, California

Regina Berkovich MD PhD Inc, West Hollywood, California

CU Anschutz Med Campus, Aurora, Colorado

Colorado Springs Neurological Associates, Colorado Springs, Colorado

Colorado Neurological Research PC, Denver, Colorado

New England Institute for Clinical Research, Stamford, Connecticut

Georgetown University Hospital Research, Washington, District of Columbia

Georgetown University Hospital, Washington, District of Columbia

SFM Clinical Research LLC, Boca Raton, Florida

Nova Clinical Research LLC, Bradenton, Florida

University of Florida, Gainesville, Florida

Memorial Healthcare System, Hollywood, Florida

Mayo Clinic Jacksonville, Jacksonville, Florida

Neurology Associates PA, Maitland, Florida

Gables Neurology, Miami, Florida

UM Department Of Neurology, Miami, Florida

Aqualane Clinical Research, Naples, Florida

Advent Health Orlando, Orlando, Florida

Humanity Clinical Research, Pembroke Pines, Florida

Emerald Coast Neurology, Pensacola, Florida

Brain and Spine Institute, Port Orange, Florida

Vero Beach Neurology, Vero Beach, Florida

Conquest Research, Winter Park, Florida

Georgia Neurology and Sleep Medicine Assoc, Suwanee, Georgia

Methodist Neuroscience Institute, Merrillville, Indiana

University of Kansas Hospital, Kansas City, Kansas

Baptist Physicians Lexington, Nicholasville, Kentucky

Ochsner Clinic Foundation, New Orleans, Louisiana

Comprehensive Neurology, Frederick, Maryland

Tufts Medical Center, Boston, Massachusetts

Memorial Healthcare, Owosso, Michigan

Kansas City VA Medical Center, Kansas City, Missouri

South Shore Neurologic Associates, Patchogue, New York

True North Neurology, Port Jefferson Station, New York

University Of NC At Chapel Hill, Chapel Hill, North Carolina

Piedmont HealthCare, Charlotte, North Carolina

The Boster Ctr for MS, Columbus, Ohio

Neurology Diagnostics Inc, Dayton, Ohio

Penn State Hershey Medical Center, Hershey, Pennsylvania

Medical Uni of South Carolina, Charleston, South Carolina

Premier Neurology, Greenville, South Carolina

Metrolina Neurological Associates PA, Indian Land, South Carolina

Sibyl Wray MD Neurology PC, Knoxville, Tennessee

Neurology Consultants Of Dallas PA, Dallas, Texas

Med Research Inc, El Paso, Texas

Lone Star Neurology, Frisco, Texas

Neurocare Plus, Houston, Texas

UT Health MARC Medical Arts and Research Center, San Antonio, Texas

Lonestar Neurology of San Antonio, San Antonio, Texas

Texas Institute for Neurological Disorders, Sherman, Texas

Baylor Scott and White, Temple, Texas

Virginia Mason Medical Centre, Seattle, Washington

University of Washington MS Clinic, Seattle, Washington

Elligo Health Research, Crab Orchard, West Virginia

Aurora BayCare Medical Center, Green Bay, Wisconsin

Ascension St Francis Center, Milwaukee, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

Novartis Investigative Site, Caba, Buenos Aires

Novartis Investigative Site, Bombal, Mendoza

Novartis Investigative Site, Rosario, Santa Fe

Novartis Investigative Site, San Miguel De, Tucuman

Novartis Investigative Site, Buenos Aires, Not set

Novartis Investigative Site, Cordoba, Not set

Novartis Investigative Site, Brasilia, DF

Novartis Investigative Site, Vitoria, ES

Novartis Investigative Site, Curitiba, PR

Novartis Investigative Site, Porto Alegre, Rio Grande Do Sul

Novartis Investigative Site, Porto Alegre, RS

Novartis Investigative Site, Joinville, Santa Catarina

Novartis Investigative Site, Sao Paulo, Not set

Novartis Investigative Site, Plovdiv, Not set

Novartis Investigative Site, Sofia, Not set

Novartis Investigative Site, Edmonton, Alberta

Novartis Investigative Site, Burnaby, British Columbia

Novartis Investigative Site, Halifax, Nova Scotia

Novartis Investigative Site, Ottawa, Ontario

Novartis Investigative Site, Greenfield Park, Quebec

Novartis Investigative Site, Levis, Quebec

Novartis Investigative Site, Montreal, Quebec

Novartis Investigative Site, St Jerome, Quebec

Novartis Investigative Site, Quebec, Not set

Novartis Investigative Site, Fuzhou, Fujian

Novartis Investigative Site, Wuhan, Hubei

Novartis Investigative Site, Nanjing, Jiangsu

Novartis Investigative Site, Yinchuan, Ningxia

Novartis Investigative Site, Taiyuan, Shanxi

Novartis Investigative Site, Hangzhou, Zhejiang

Novartis Investigative Site, Wenzhou, Zhejiang

Novartis Investigative Site, Beijing, Not set

Novartis Investigative Site, Shanghai, Not set

Novartis Investigative Site, Split, HRV

Novartis Investigative Site, Varazdin, HRV

Novartis Investigative Site, Vukovar, Not set

Novartis Investigative Site, Zagreb, Not set

Novartis Investigative Site, Tallinn, Not set

Novartis Investigative Site, Tartu, Not set

Novartis Investigative Site, Limoges, Haute Vienne

Novartis Investigative Site, Toulon Cedex 9, Val De Marne

Novartis Investigative Site, Caen, Not set

Novartis Investigative Site, Clermont-Ferrand Cedex 1, Not set

Novartis Investigative Site, Contamine Sur Arve, Not set

Novartis Investigative Site, Dijon, Not set

Novartis Investigative Site, Gonesse, Not set

Novartis Investigative Site, Grenoble, Not set

Novartis Investigative Site, Lille, Not set

Novartis Investigative Site, Marseille, Not set

Novartis Investigative Site, Nantes Cedex 1, Not set

Novartis Investigative Site, Nice, Not set

Novartis Investigative Site, Nimes, Not set

Novartis Investigative Site, Poissy, Not set

Novartis Investigative Site, Suresnes, Not set

Novartis Investigative Site, Toulouse, Not set

Novartis Investigative Site, Chaidari, Attiki

Novartis Investigative Site, Ioannina, GR

Novartis Investigative Site, Larissa, GR

Novartis Investigative Site, Athens, Not set

Novartis Investigative Site, Greece, Not set

Novartis Investigative Site, Thessaloniki, Not set

Novartis Investigative Site, New Delhi, Delhi

Novartis Investigative Site, Kochi, Kerala

Novartis Investigative Site, Pune, Maharashtra

Novartis Investigative Site, Amritsar, Punjab

Novartis Investigative Site, Hyderabad, Telangana

Novartis Investigative Site, Lucknow, Uttar Pradesh

Novartis Investigative Site, Kolkata, West Bengal

Novartis Investigative Site, Brindisi, BR

Novartis Investigative Site, Foggia, FG

Novartis Investigative Site, Firenze, FI

Novartis Investigative Site, Pozzilli, IS

Novartis Investigative Site, Messina, ME

Novartis Investigative Site, Baggiovara, MO

Novartis Investigative Site, Pavia, PV

Novartis Investigative Site, Orbassano, TO

Novartis Investigative Site, Napoli, Not set

Novartis Investigative Site, Nagoya, Aichi

Novartis Investigative Site, Ichihara, Chiba

Novartis Investigative Site, Fukuoka city, Fukuoka

Novartis Investigative Site, Koriyama city, Fukushima

Novartis Investigative Site, Sapporo city, Hokkaido

Novartis Investigative Site, Nishinomiya, Hyogo

Novartis Investigative Site, Isehara, Kanagawa

Novartis Investigative Site, Sagamihara, Kanagawa

Novartis Investigative Site, Sendai city, Miyagi

Novartis Investigative Site, Kashihara city, Nara

Novartis Investigative Site, Moriguchi, Osaka

Novartis Investigative Site, Suita, Osaka

Novartis Investigative Site, Higashimatsuyama, Saitama

Novartis Investigative Site, Itabashi-ku, Tokyo

Novartis Investigative Site, Kodaira, Tokyo

Novartis Investigative Site, Shinjuku Ku, Tokyo

Novartis Investigative Site, Shinjuku ku, Tokyo

Novartis Investigative Site, Shinjuku-ku, Tokyo

Novartis Investigative Site, Chiba, Not set

Novartis Investigative Site, Fukuoka, Not set

Novartis Investigative Site, Kobe shi, Not set

Novartis Investigative Site, Kyoto, Not set

Novartis Investigative Site, Niigata, Not set

Novartis Investigative Site, Ciudad de Mexico, Distrito Federal

Novartis Investigative Site, Chihuahua, Not set

Novartis Investigative Site, Ciudad De Mexico, Not set

Novartis Investigative Site, Queretaro, Not set

Novartis Investigative Site, Plewiska, Poznan

Novartis Investigative Site, Bialystok, Not set

Novartis Investigative Site, Glogow, Not set

Novartis Investigative Site, Katowice, Not set

Novartis Investigative Site, Krakow, Not set

Novartis Investigative Site, Wroclaw, Not set

Novartis Investigative Site, Zabrze, Not set

Novartis Investigative Site, Braga, Not set

Novartis Investigative Site, Coimbra, Not set

Novartis Investigative Site, Leiria, Not set

Novartis Investigative Site, Lisboa, Not set

Novartis Investigative Site, Matosinhos, Not set

Novartis Investigative Site, Santa Maria da Feira, Not set

Caribbean Center for Clinical Research, Inc, Guaynabo, Not set

Novartis Investigative Site, Targu Mures, Mures

Novartis Investigative Site, Brasov, ROM

Novartis Investigative Site, Constanta, ROM

Novartis Investigative Site, Bucharest, Not set

Novartis Investigative Site, Campulung Muscel, Not set

Novartis Investigative Site, Constanta, Not set

Novartis Investigative Site, Suceava, Not set

Novartis Investigative Site, Banska Bystrica, Not set

Novartis Investigative Site, Bratislava, Not set

Novartis Investigative Site, Celje, Not set

Novartis Investigative Site, Ljubljana, Not set

Novartis Investigative Site, Maribor, Not set

Novartis Investigative Site, Bloemfontein, Free State

Novartis Investigative Site, Pretoria, Not set

Novartis Investigative Site, Rosebank, Not set

Novartis Investigative Site, Sevilla, Andalucia

Novartis Investigative Site, Vitoria Gasteiz, Araba

Novartis Investigative Site, Gijon, Asturias

Novartis Investigative Site, Hospitalet de Llobregat, Barcelona

Novartis Investigative Site, Albacete, Castilla La Mancha

Novartis Investigative Site, Badalona, Catalunya

Novartis Investigative Site, Barcelona, Catalunya

Novartis Investigative Site, Valencia, Comunidad Valenciana

Novartis Investigative Site, Santiago De Compostela, Galicia

Novartis Investigative Site, Logrono, La Rioja

Novartis Investigative Site, Pozuelo de Alarcon, Madrid

Novartis Investigative Site, Torrejon de Ardoz, Madrid

Novartis Investigative Site, Barcelona, Not set

Novartis Investigative Site, Lleida, Not set

Novartis Investigative Site, Madrid, Not set

Novartis Investigative Site, Malaga, Not set

Novartis Investigative Site, Valencia, Not set

Novartis Investigative Site, Stockholm, Not set

Novartis Investigative Site, Sancaktepe, Istanbul

Novartis Investigative Site, Istanbul, TUR

Novartis Investigative Site, Bursa, Not set

Novartis Investigative Site, Istanbul, Not set

Novartis Investigative Site, Izmir, Not set

Novartis Investigative Site, Kayseri, Not set

Novartis Investigative Site, Kocaeli, Not set

Novartis Investigative Site, Meram, Not set

Novartis Investigative Site, Pendik Istanbul, Not set

Novartis Investigative Site, Samsun, Not set

Novartis Investigative Site, Inverness, Invernesshire

Novartis Investigative Site, Canterbury, Kent

Novartis Investigative Site, London, Not set

Conditions: Relapsing Multiple Sclerosis

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A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

NCT06459180

Recruiting

This study will have two phases: a sacituzumab tirumotecan safety run-in and a Phase 3 portion. The safety run-in phase will be used to evaluate the efficacy and safety of sacituzumab tirumotecan at the dose for evaluation in the Phase 3 portion. The purpose of this study is to compare the efficacy and safety of sacituzumab tirumotecan versus treatment of physician's choice as second-line treatment for participants with recurrent or metastatic cervical cancer in the Phase 3 portion. The primary... Read More

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: USA Mitchell Cancer Institute-Clinical Trials ( Site 4126), Mobile, Alabama +215 locations

USA Mitchell Cancer Institute-Clinical Trials ( Site 4126), Mobile, Alabama

Providence Alaska Medical Center ( Site 4137), Anchorage, Alaska

HonorHealth (HH) ( Site 8002), Phoenix, Arizona

Arizona Oncology Associates - HOPE ( Site 8001), Tucson, Arizona

Moores Cancer Center-Clinical Trials Office - Gynecological Oncology ( Site 4125), La Jolla, California

UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4105), Los Angeles, California

Hoag Memorial Hospital Presbyterian ( Site 4104), Newport Beach, California

Mount Sinai Comprehensive Cancer Center ( Site 4143), Miami Beach, Florida

Advent Health ( Site 4140), Orlando, Florida

Florida Cancer Specialists East ( Site 7001), West Palm Beach, Florida

Northside Hospital ( Site 4127), Atlanta, Georgia

Georgia Cancer Center at Augusta University ( Site 4112), Augusta, Georgia

Lewis Cancer and Research Pavilion ( Site 4114), Savannah, Georgia

University Medical Center New Orleans ( Site 4132), New Orleans, Louisiana

Willis Knighton Medical Center ( Site 4101), Shreveport, Louisiana

The Center of Hope ( Site 4106), Reno, Nevada

Holy Name Medical Center ( Site 4117), Teaneck, New Jersey

Optimum Clinical Research Group ( Site 4138), Albuquerque, New Mexico

Duke Cancer Institute ( Site 4120), Durham, North Carolina

University of Cincinnati Medical Center ( Site 4128), Cincinnati, Ohio

The Ohio State University ( Site 4103), Hilliard, Ohio

Oklahoma Cancer Specialists and Research Institute, LLC-Clinical Research ( Site 4116), Tulsa, Oklahoma

Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007), Eugene, Oregon

Legacy Good Samaritan Medical Center-Oncology Clinical Research ( Site 4115), Portland, Oregon

Sidney Kimmel Cancer Center - Jefferson Health ( Site 4142), Philadelphia, Pennsylvania

Asplundh Cancer Pavilion ( Site 4113), Willow Grove, Pennsylvania

Texas Oncology - DFW ( Site 8003), Fort Worth, Texas

Houston Methodist Hospital OB/GYN ( Site 4102), Houston, Texas

Texas Oncology - San Antonio ( Site 8006), San Antonio, Texas

University of Virginia Cancer Center ( Site 4123), Charlottesville, Virginia

Inova Schar Cancer Institute ( Site 4139), Fairfax, Virginia

Swedish Medical Center-Swedish Cancer Institute ( Site 4134), Seattle, Washington

Hospital Británico de Buenos Aires-Oncology ( Site 0102), Ciudad autónoma de Buenos Aires, Buenos Aires

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0107), Mar del Plata, Buenos Aires

Instituto de Oncología Angel H. Roffo ( Site 0103), Buenos Aires, Caba

Instituto Alexander Fleming ( Site 0108), Buenos Aires, Caba

Sanatorio Allende - Cerro-Oncology ( Site 0106), Córdoba, Cordoba

Hospital Aleman-Oncology ( Site 0100), Buenos Aires, Not set

Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0109), Caba, Not set

Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0104), La Rioja, Not set

Blacktown Hospital ( Site 3006), Sydney, New South Wales

Campbelltown Hospital-Macarthur Cancer Therapy Centre Medical Oncology ( Site 3000), Sydney, New South Wales

Royal Brisbane and Women's Hospital ( Site 3001), Herston, Queensland

Monash Health-Oncology Research ( Site 3002), Clayton, Victoria

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3005), Melbourne, Victoria

Sir Charles Gairdner Hospital ( Site 3003), Nedlands, Western Australia

Kepler Universitätsklinikum-Department for Oncology and Hematology ( Site 1002), Linz, Oberosterreich

Medizinische Universität Graz-Abteilung für Gynäkologie / Onkologie ( Site 1003), Graz, Steiermark

Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 1000), Innsbruck, Tirol

Medizinische Universität Wien ( Site 1001), Wien, Not set

AZORG Campus Aalst-Moorselbaan ( Site 2905), Aalst, Oost-Vlaanderen

UZ Gent-Medical oncology ( Site 2901), Gent, Oost-Vlaanderen

UZ Leuven-Gynecologic Oncology ( Site 2900), Leuven, Vlaams-Brabant

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman-Medical Oncology ( Site 2904), Belgium, Wallonne, Region

CHU UCL Namur/Site Sainte Elisabeth-Trial Office ( Site 2902), Namur, Not set

Instituto do Câncer e Transplante de Curitiba ( Site 0205), Curitiba, Parana

Hospital Moinhos de Vento-Centro de Pesquisa Clínica ( Site 0204), Porto Alegre, Rio Grande Do Sul

Hospital do Câncer Mãe de Deus ( Site 0201), Porto Alegre, Rio Grande Do Sul

Centro de Hematologia e Oncologia ( Site 0203), Joinville, Santa Catarina

IBCC - Instituto Brasileiro de Controle do Câncer-Centro de Pesquisa Clínica ( Site 0200), São Paulo, Sao Paulo

Americas Centro de Oncologia Integrado ( Site 0202), Rio de Janeiro, Not set

Hospital Paulistano ( Site 0209), Sao Paulo, Not set

MBAL Uni Hospital-Department of Medical Oncology ( Site 1104), Panagyurishte, Pazardzhik

MHAT - Heart and Brain ( Site 1100), Pleven, Not set

Complex Oncology Center - Plovdiv EOOD ( Site 1102), Plovdiv, Not set

BC Cancer Kelowna ( Site 4007), Kelowna, British Columbia

BC Cancer Surrey ( Site 4006), Surrey, British Columbia

BC Cancer Victoria ( Site 4008), Victoria, British Columbia

Royal Victoria Regional Health Centre ( Site 4009), Barrie, Ontario

McGill University Health Centre ( Site 4000), Montreal, Quebec

Centre Hospitalier de l'Université de Montréal ( Site 4001), Montréal, Quebec

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 4002), Quebec City, Quebec

FALP-UIDO ( Site 0300), Santiago, Region M. De Santiago

Pontificia Universidad Catolica de Chile ( Site 0302), Santiago, Region M. De Santiago

ONCOCENTRO APYS-ACEREY ( Site 0303), Viña del Mar, Valparaiso

Anhui Provincial Cancer Hospital-Gynecological Oncology ( Site 5040), Hefei, Anhui

Anhui Provincial Hospital ( Site 5011), Hefei, Anhui

Beijing Peking Union Medical College Hospital ( Site 5045), Beijing, Beijing

Chongqing University Cancer Hospital ( Site 5003), Chongqing, Chongqing

Fujian Provincial Cancer Hospial ( Site 5012), Fuzhou, Fujian

The First Affiliated hospital of Xiamen University-Obstetrics and gynecology department ( Site 5027), Xiamen, Fujian

Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 5001), Guangzhou, Guangdong

Sun Yat-sen University Cancer Center-Internal medicine ( Site 5006), Guangzhou, Guangdong

Affiliated Hospital of Guangdong Medical University ( Site 5004), Zhanjiang, Guangdong

Guangxi Medical University Affiliated Tumor Hospital ( Site 5016), Nanning, Guangxi

Hainan General Hospital ( Site 5032), Haikou, Hainan

Harbin Medical University Cancer Hospital ( Site 5010), Harbin, Heilongjiang

The First Affiliated Hospital of Xinxiang Medical University-Oncology ( Site 5041), Xinxiang, Henan

Henan Cancer Hospital ( Site 5026), Zhengzhou, Henan

Wuhan Union Hospital ( Site 5020), Wuhan, Hubei

Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 5019), Wuhan, Hubei

Hunan Cancer Hospital ( Site 5021), Changsha, Hunan

Xiangya Hospital Central South University ( Site 5009), Changsha, Hunan

Jiangsu Province Hospital-Oncology Department ( Site 5018), Nanjing, Jiangsu

Jiangxi Maternal and Child Health Hospital ( Site 5031), Nanchang, Jiangxi

Jilin Province Tumor Hospital ( Site 5036), Changchun, Jilin

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 5007), Xi'an, Shaanxi

Shandong Cancer Hospital ( Site 5014), Jinan, Shandong

LinYi Cancer Hospital-Gastrology department ( Site 5039), Linyi, Shandong

Obstetrics & Gynecology Hospital of Fudan University ( Site 5015), Shanghai, Shanghai

Shanxi Cancer Hospital ( Site 5043), Taiyuan, Shanxi

West China Second University Hospital, Sichuan University ( Site 5017), Chengdu, Sichuan

Sichuan Cancer hospital-Oncology ( Site 5030), Chengdu, Sichuan

Yunnan Province Cancer Hospital-Gynecology Department ( Site 5005), Kunming, Yunnan

Women s Hospital School of Medicine Zhejiang University ( Site 5022), Hangzhou, Zhejiang

Zhejiang Cancer Hospital ( Site 5008), Hangzhou, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University ( Site 5033), Wenzhou, Zhejiang

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0401), Valledupar, Cesar

IMAT S.A.S ( Site 0402), Montería, Cordoba

Instituto Nacional De Cancerologia-Oncología Clínica ( Site 0404), Bogota, Cundinamarca

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0403), Bogota., Distrito Capital De Bogota

Oncologos del Occidente ( Site 0405), Pereira., Risaralda

Fundación Valle del Lili ( Site 0406), Cali, Valle Del Cauca

Rigshospitalet-Dept. of Oncology ( Site 1300), Kobenhavn, Hovedstaden

Aarhus Universitetshospital, Skejby ( Site 1301), Aarhus, Midtjylland

Odense Universitetshospital-Department of oncology ( Site 1302), Odense C, Syddanmark

Tampereen yliopistollinen sairaala-Gynecology and Obstetrics ( Site 1404), Tampere, Pirkanmaa

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1400), Helsinki, Uusimaa

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1401), Turku, Varsinais-Suomi

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1501), Strasbourg, Alsace

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1503), Bordeaux, Aquitaine

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1508), Clermont-Ferrand, Auvergne

Institut Paoli-Calmettes ( Site 1504), Marseille, Bouches-du-Rhone

Hôpital Privé Des Côtes d'Armor ( Site 1510), Plérin, Cotes-d Armor

CHU Besançon ( Site 1507), Besancon, Franche-Comte

Oncopole Claudius Regaud ( Site 1502), Toulouse, Haute-Garonne

Institut Regional du Cancer Montpellier ( Site 1511), Montpellier, Herault

Gustave Roussy ( Site 1512), Villejuif, Ile-de-France

Hôpital privé du Confluent SAS ( Site 1509), Nantes, Loire-Atlantique

CENTRE LEON BERARD ( Site 1505), Lyon Cedex08, Rhone-Alpes

Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1506), Paris, Not set

Aretaieio Hospital ( Site 1700), Athens, Attiki

Mitera Hospital ( Site 1702), Athens, Attiki

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1703), Chaidari, Attiki

Agios Andreas Hospital Patras ( Site 1701), Patras, Peloponnisos

Cork University Hospital ( Site 1900), Cork, Not set

Mater Misericordiae University Hospital ( Site 1901), Dublin, Not set

St. James's Hospital-Cancer clinical trials office ( Site 1902), Dublin, Not set

Rambam Health Care Campus ( Site 2002), Haifa, Not set

Edith Wolfson Medical Center ( Site 2003), Holon, Not set

Hadassah Medical Center ( Site 2000), Jerusalem, Not set

Sheba Medical Center ( Site 2001), Ramat Gan, Not set

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlin-DEPARTMENT OF EXPERIMENTAL, DIAGNOSTIC ( Site 2105), Bologna, Emilia-Romagna

Istituto Europeo di Oncologia IRCCS ( Site 2108), Milano, Lombardia

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 2107), Milan, Lombardia

Ospedale Humanitas San Pio X ( Site 2113), Milan, Lombardia

Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2111), Monza, Lombardia

Humanitas University ( Site 2112), Rozzano, Milano

Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 2100), Torino, Piemonte

Azienda Ospedaliera Spedali Civili di Brescia-Obstetrics anf gynecology ( Site 2110), Brescia, Not set

Ospedale Cannizzaro ( Site 2104), Catania, Not set

Ospedale San Raffaele. ( Site 2106), Milano, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2103), Napoli, Not set

Istituto Oncologico Veneto IRCCS ( Site 2109), Padova, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2102), Roma, Not set

Aichi Cancer Center ( Site 5110), Nagoya, Aichi

National Cancer Center Hospital East ( Site 5113), Kashiwa, Chiba

National Hospital Organization Shikoku Cancer Center ( Site 5109), Matsuyama, Ehime

Ehime University Hospital ( Site 5102), Toon, Ehime

Kurume University Hospital ( Site 5105), Kurume, Fukuoka

Gunma Prefectural Cancer Center ( Site 5116), Ohta, Gunma

Hokkaido University Hospital ( Site 5106), Sapporo, Hokkaido

University of Tsukuba Hospital ( Site 5114), Tsukuba, Ibaraki

Iwate Medical University Hospital ( Site 5112), Shiwa-gun, Iwate

Saitama Medical University International Medical Center ( Site 5117), Hidaka, Saitama

Shizuoka Cancer Center ( Site 5107), Sunto-gun,, Shizuoka

National Cancer Center Hospital ( Site 5108), Chuo, Tokyo

Cancer Institute Hospital of JFCR ( Site 5111), Koto, Tokyo

Keio University Hospital ( Site 5101), Shinjyuku, Tokyo

National Hospital Organization Kyushu Cancer Center ( Site 5104), Fukuoka, Not set

Kagoshima City Hospital ( Site 5115), Kagoshima, Not set

Niigata Cancer Center Hospital ( Site 5100), Niigata, Not set

Osaka International Cancer Institute ( Site 5103), Osaka, Not set

Seoul National University Hospital ( Site 3403), Seoul, Not set

Severance Hospital, Yonsei University Health System ( Site 3402), Seoul, Not set

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 3401), Seoul, Not set

Samsung Medical Center ( Site 3400), Seoul, Not set

University Malaya Medical Centre ( Site 3102), Lembah Pantai, Kuala Lumpur

Sunway Medical Centre ( Site 3105), Petaling Jaya, Selangor

Pantai Hospital Kuala Lumpur ( Site 3100), Kuala Lumpur, Not set

Penang Adventist Hospital ( Site 3101), Pulau Pinang, Not set

Radboudumc-Medical Oncology ( Site 2202), Nijmegen, Gelderland

Catharina Ziekenhuis-Oncology ( Site 2203), Eindhoven, Noord-Brabant

Amsterdam UMC, locatie VUmc ( Site 2201), Amsterdam, Noord-Holland

Erasmus Medisch Centrum-Medical Oncology ( Site 2200), Rotterdam, Zuid-Holland

University Medical Center Groningen ( Site 2204), Groningen, Not set

Oslo universitetssykehus, Radiumhospitalet ( Site 2300), Oslo, Not set

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 2400), Warszawa, Mazowieckie

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2402), Bialystok, Podlaskie

Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 2404), Poznan, Wielkopolskie

UPR Comprehensive Cancer Center-Comprehensive Cancer Center Hospital ( Site 0601), San Juan, Not set

National University Hospital ( Site 3301), Singapore, Central Singapore

National Cancer Centre Singapore ( Site 3300), Singapore, Central Singapore

HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 2509), Barcelona, Cataluna

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2508), L Hospitalet De Llobregat, Cataluna

Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 2507), Girona, Gerona

Clinica Universidad de Navarra ( Site 2510), Madrid, Madrid, Comunidad De

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2502), Madrid, Madrid, Comunidad De

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 2506), Madrid, Madrid, Comunidad De

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2503), Valencia, Valenciana, Comunitat

HOSPITAL CLINICO DE VALENCIA ( Site 2505), Valencia, Valenciana, Comunitat

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2500), Barcelona, Not set

Hospital Universitario Reina Sofia-Oncologia Medica ( Site 2501), Cordoba, Not set

Hospital Universitario La Paz-Oncología Médica ( Site 2504), Madrid, Not set

Universitetssjukhuset i Linköping ( Site 2600), Linköping, Ostergotlands Lan

Skånes Universitetssjukhus Lund-Department of Hematology ( Site 2602), Lund, Skane Lan

Karolinska Universitetssjukhuset Solna ( Site 2601), Stockholm, Stockholms Lan

Akademiska sjukhuset ( Site 2603), Uppsala, Uppsala Lan

University Hospital Basel-Gynecology & Gynecologic Oncology ( Site 2701), Basel, Basel-Stadt

Inselspital Bern-Oncology ( Site 2700), Berne, Not set

ROYAL MARSDEN HOSPITAL (CHELSEA)-Gynaecology Research Centre ( Site 2807), London, England

Royal Marsden Hospital (Sutton)-Gynaecology Unit ( Site 2801), Sutton, England

Gartnavel General Hospital-Clinical Trials Unit ( Site 2800), Glasgow, Glasgow City

University College London Hospital ( Site 2805), London, London, City Of

St James's University Hospital ( Site 2804), Leeds, Not set

The Christie NHS Foundation Trust-Research and Development ( Site 2802), Manchester, Not set

Conditions: Cervical Cancer

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