Study the Effect of Upper Expansion Appliances on Lower Jaw Forward Projection/Growth
NCT03286569
Recruiting
Young children with backward positioned lower jaw/chin will be recruited to have an upper jaw expansion appliance. Previous research showed that the use of similar appliances can lead to lower jaw forward growth. 60 young children aged 9-11 will be recruited to have either active or non-active Wilson type upper arch expansion appliance. Patients will have special x-ray (Cone Beam computed tomography) before and after treatment (after 9 months) of starting the treatment. After participation, rout... Read More
Gender:
ALL
Ages:
Between 9 years and 11 years
Trial Updated:
11/03/2024
Locations: University of Alberta, Edmonton, Alberta
Conditions: Overbite (Excessive) Horizontal
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Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation
NCT04195256
Recruiting
Orthopedic injuries comprise more than 10% of ED visits in children and 25 to 50% of children will sustain a fracture before age 16 years. Distal radius fractures account for 20-32% of fractures in children, making them the most common fracture type. Between 20 and 40% of extremity fractures in children require a closed reduction, often necessitating procedural sedation and analgesia (PSA). Intravenous (IV) ketamine is the most commonly used sedative agent used to perform a closed reduction. How... Read More
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
11/01/2024
Locations: Stollery Children's Hospital, Edmonton, Alberta +5 locations
Conditions: Fracture, Dislocation
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Optimizing CBSST with Executive Function Training for Schizophrenia
NCT06251193
Recruiting
The purpose of this research study to test a blended intervention that combines Executive Function Training with Cognitive-Behavioral Skills Training (E-CBSST). The aims include determining whether E-CBSST is feasible and increases Cognitive Behavioral Social Skills Training (CBSST) Skills Learning to a level that will lead to a clinically meaningful improvement in functioning.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/01/2024
Locations: UC San Diego, La Jolla, California +1 locations
Conditions: Schizophrenia, Schizoaffective Disorder
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Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth
NCT06672562
Recruiting
The goal of this pilot clinical trial is to assess the feasibility of conducting a full-scale study to learn if a new youth-adapted Narrative Enhancement and Cognitive Therapy (NECT-Y) reduces self-stigma in youth living with bipolar disorder or multiple mental health conditions. The main questions it aims to answer are: * What is the feasibility of conducting a definitive clinical trial in terms of recruitment success, study retention/compliance, treatment retention/compliance, and absence of... Read More
Gender:
ALL
Ages:
Between 16 years and 29 years
Trial Updated:
11/01/2024
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Bipolar Disorder, Multiple Mental Health Conditions
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Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
NCT05632601
Recruiting
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary revascularization, stroke, total and cardiovascular mortality). This future study will be the first longitudinal cohort study, to our knowledge, that is focused entirely on researching the pathophysiology and natural history of cardiovascular disease in women with known fem... Read More
Gender:
FEMALE
Ages:
Between 25 years and 55 years
Trial Updated:
10/31/2024
Locations: University of Ottawa Heart Institute, Ottawa, Ontario
Conditions: Cardiovascular Diseases
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Directional Bilateral Thalamic Patterned Stimulation (Chronos)
NCT06325852
Recruiting
Population Size and Eligible Patients: The investigators aim to recruit 5 to 10 patients with tremors who have previously undergone Ventral Intermedius Deep Brain Stimulation (VIM-DBS) treatment but have experienced early or late loss of benefits. Additionally, the investigators will enroll ten patients with essential tremor who require VIM-DBS surgery. These individuals will undergo bilateral implantation of Boston Scientific Genus Implantable Pulse Generator (IPG) devices, connected to Boston... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/31/2024
Locations: Movement Disorders Centre - Toronto Western Hospital, Toronto, Ontario
Conditions: Essential Tremor
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Study of Individuals Affected With Hypoplasminogenemia
NCT03797495
Recruiting
This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities
Gender:
ALL
Ages:
All
Trial Updated:
10/30/2024
Locations: Rush University Medical Center, Chicago, Illinois +21 locations
Conditions: Plasminogen Deficiency
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UPTAKE - Virtual Care: Virtual Home Hospital With Remote Monitoring to Reduce Acute Care Hospitalization
NCT06537453
Recruiting
Method: Randomized Controlled Trial Study Duration: 3 Years Study Centre(s) University of Calgary and University of Alberta Objectives: To fill care gaps by implementing strategies to reduce length of hospital stay, readmission rates, and improve long-term outcomes after Acute Kidney Injury (AKI). Number of Participants: Three Hundred and fifty four (n=354) Diagnosis and Main Inclusion Criteria: Hospitalized adults with AKI at high risk of hospital readmission or death Study Intervention: Multi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: University of Calgary, Calgary, Alberta +1 locations
Conditions: Acute Kidney Injury
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The DRAGON 2 Trial
NCT05428735
Recruiting
In the randomized controlled DRAGON 2 trial study subjects will be randomized between two arms, PVE alone (control group) and PVE/HVE (interventional group).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut +23 locations
Conditions: Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR)
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One-Month DAPT in CABG Patients
NCT05997693
Recruiting
The purpose of this study is to compare the effect of ticagrelor plus low-dose aspirin versus low-dose aspirin alone in patients with chronic coronary disease undergoing coronary artery bypass grafting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Weill Cornell Medicine, New York, New York +11 locations
Conditions: Chronic Coronary Disease
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Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma
NCT05352672
Recruiting
This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called REGN2810, also known as cemiplimab (each individually called a "study drug" or called "study drugs" when combined). The study is focused on patients with a type of skin cancer known as melanoma. The aims of the study are to see how effective the combination of fianlimab and cemiplimab are in treating the melanoma skin cancer, in comparison with a medicati... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
10/28/2024
Locations: University of California San Diego, La Jolla, California +218 locations
Conditions: Melanoma
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Emergency Medicine Pulmonary Embolism Testing Multicentre Study
NCT06320236
Recruiting
It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2024
Locations: Kingston Health Sciences Centre, Kingston, Ontario
Conditions: Pulmonary Embolism, D-dimer, Diagnosis
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