TES RCT Fleet Enema vs Oral Mechanical Bowel Prep
Recruiting
There is no consensus about the best bowel preparation prior to transanal endoscopic surgery TES). Cleanliness and visibility in the rectosigmoid and rectum are of utmost importance, possibly even more so than during colonoscopy, to facilitate safe, precise and efficient resection of the rectal lesion and potentially adequate closure of the defect. Both Fleet enemas and oral mechanical bowel preparation are considered standard of care in preparation for TES. This single center two arm single bli... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/24/2024
Locations: Victoria General Hospital, Halifax, Nova Scotia
Conditions: Colorectal Neoplasms, Surgery
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, Alabama +59 locations
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
Early Detection of Liver Cancer by QUS
Recruiting
Worldwide, liver cancers are the third most common cause of cancer mortality. Even when liver cancer is suspected by blood tests, imaging is required to determine the location, size, and extent of disease. Medical societies therefore recommend surveillance with ultrasound every 6 months in at-risk patients. However, a key challenge to improving the survival is that ultrasound may miss half of early-stage liver cancers, thus diagnosis must rely on additional tests such as computed tomography (CT)... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Quebec
Conditions: Hepatocellular Carcinoma, Liver Cancer
The European Paediatric Network for Haemophilia Management ( PedNet Registry)
Recruiting
Rationale: Haemophilia is a rare disease; to improve knowledge international collaboration is needed. Well-defined clinical data will be collected from complete cohorts in order to prevent selection bias. Objective: To collect data on bleeding during neonatal period, endogenous (genetic) and exogenous (treatment-related) determinants of inhibitor development and long term outcome.
Gender:
ALL
Ages:
All
Trial Updated:
08/22/2024
Locations: Universitäts-Klinik für Kinder- und Jugendheilkunde, Graz, Not set +38 locations
Conditions: Factor VIII Deficiency, Factor IX Deficiency
68Ga-DOTATATE Neuroblastoma Imaging Pilot
Recruiting
Neuroblastoma is the most frequent extracranial childhood tumor, with an annual incidence of approximately 10.2 per million children. Staging of the disease can be done by different imaging strategies (CT, MRI, scintigraphy and PET/CT). Discrepancies may be observed among these different strategies resulting in different treatment strategies. The goal of this study is to assess the feasibility and safety of 68Ga-DOTATATE and to compare it to 123I-MIBG when investigating neuroblastoma.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
08/22/2024
Locations: McGill University Health Center - Children's hospital, Montréal, Quebec +2 locations
Conditions: Neuroblastoma
Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome
Recruiting
Perinatal depression and anxiety (PDA) are the leading causes of maternal mortality in developed countries. Women with a history of depression have a 20 fold higher risk of PDA at subsequent pregnancies. The adverse outcomes extend beyond maternal well-being to long-term deficits in children and families. The gut-brain axis is a newly recognized key player in mental health disorders. Specifically, the microbial composition of the gut along with their metabolites are directly involved in disease... Read More
Gender:
FEMALE
Ages:
Between 18 years and 43 years
Trial Updated:
08/22/2024
Locations: Sunnybrook Health Science Center, Toronto, Ontario
Conditions: Perinatal Depression, PerinatalAnxiety
Evaluating Cannabidiol as a Novel Anticraving Medication for Alcohol Use Disorder
Recruiting
This human laboratory study aims to assess the effects of cannabidiol on alcohol consumption and craving in participants with alcohol use disorder. In this double-blind within-subject placebo-controlled crossover trial, participants will be randomized to receive both cannabidiol and placebo with a 2-week washout period separating the two treatment phases.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
08/22/2024
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Alcohol Use Disorder
Predicting Appendicular Lean and Fat Mass With Bioelectrical Impedance Analysis Among Adult Patients With Obesity.
Recruiting
This study aims to develop and cross-validate novel bioelectrical impedance analysis (BIA) equations for predicting appendicular soft tissue masses, specifically fat mass (FM) and appendicular lean mass (ALM), in a sample of Caucasian adult subjects affected by obesity. The research will compare these new BIA equations with three established BIA-derived prediction models and validate them using dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) data. This study utilizes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2024
Locations: Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana +8 locations
Conditions: Obesity
S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +841 locations
Conditions: Multiple Myeloma
Topical Infliximab in Eyes With Penetrating Keratoplasty
Recruiting
Penetrating keratoplasty is a cornea surgery involving several inflammatory complications, of which the most important is glaucoma. Researchers wish to determine whether it is safe to administer infliximab (an anti-inflammatory drug) eye drops after surgery, and whether this eye drop could prevent the occurrence of glaucoma.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/21/2024
Locations: Centre Hospitalier de l'Université de Montréal, Montréal, Quebec
Conditions: Glaucoma Following Surgery
Piloting of an Intervention to Reduce Problematic Alcohol Use in Early Phase Psychosis Patients
Recruiting
A focus of research for youth and Emerging Adults with early phase psychosis (EPP) has been cannabis use. However, this focus has led to overlooking the possible negative influence of another legal recreational drug, alcohol. Previous studies our research group has done have demonstrated that over use of alcohol reduces the effectiveness of early intervention in psychosis treatment services. These treatment services are wrap around services that address medical, and social needs of young people... Read More
Gender:
ALL
Ages:
Between 16 years and 35 years
Trial Updated:
08/21/2024
Locations: Nova Scotia Health Authority, Halifax, Nova Scotia
Conditions: Psychosis, Alcohol Use Disorder
PATH Program for for Severely Frail or Cognitively Impaired Patients Scheduled for Cancer Surgery.
Recruiting
This is a single center, non-blinded randomized control trial taking place at the Queen Elizabeth II hospital (QEII) in Nova Scotia. Patients are eligible if aged 75 and older scheduled for elective cancer surgery (proven cancer or highly suspicious cancer) and screened to have mild or greater frailty (with cognitive impairments) or moderate to greater frailty (with medical/physical conditions). Eligible participants will then be randomized to preoperative standard of care or geriatric assessmen... Read More
Gender:
ALL
Ages:
75 years and above
Trial Updated:
08/21/2024
Locations: QEII, Victoria General Hospital, Halifax, Nova Scotia
Conditions: Frailty, Oncology Problem, Cognitive Impairment