Brain Imaging Study on Biomarkers for Fibromyalgia
NCT03910010
Recruiting
Drugs used for managing Fibromyalgia pain have not proven to be effective and pain continues to cost Canadians $60 billion a year without truly helping those who suffer. The study proposes to investigate the factors related to a person that can enhance or reduce the effectiveness of pain treatments in people suffering with Fibromyalgia pain. Treatment response to painkillers in a person may be related to their brain, social, and psychological makeup. The investigators aim to study these factors... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Nova Scotia Health Authority, Halifax, Nova Scotia
Conditions: Fibromyalgia
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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
NCT04071457
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +841 locations
Conditions: Multiple Myeloma
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The ACTS Trial: N-acetylcysteine (NAC) and Night-splinting as a Non-operative Treatment for Carpal Tunnel Syndrome
NCT04460521
Recruiting
Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome worldwide, causing significant chronic pain, functional impairment, and lowered quality of life for individuals of various backgrounds. CTS is caused by chronic compression of the median nerve in the carpal tunnel of the wrist, causing numbness and pain in the palm, thumb, index, and middle fingers and eventual weakness of the hand. Many different treatments for CTS have been proposed and studied, including but not limite... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: Queen Elizabeth II Health Sciences Center, Halifax Infirmary Site, Halifax, Nova Scotia
Conditions: Carpal Tunnel Syndrome, Hand Injuries and Disorders, Nerve Compression, Splints, Carpal Tunnel, Carpal Tunnel Release
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The Effect of Weight Bearing on Patient Outcomes Following 1st MTP Joint Fusion
NCT04473196
Recruiting
randomized-controlled trial looking specifically at the effect of weight bearing on the outcomes of first MTP joint fusions
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: Nova Scotia Health Authority, Halifax, Nova Scotia
Conditions: Hallux Valgus, Hallux Rigidus
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Topical Infliximab in Eyes With Penetrating Keratoplasty
NCT05180994
Recruiting
Penetrating keratoplasty is a cornea surgery involving several inflammatory complications, of which the most important is glaucoma. Researchers wish to determine whether it is safe to administer infliximab (an anti-inflammatory drug) eye drops after surgery, and whether this eye drop could prevent the occurrence of glaucoma.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/21/2024
Locations: Centre Hospitalier de l'Université de Montréal, Montréal, Quebec
Conditions: Glaucoma Following Surgery
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Piloting of an Intervention to Reduce Problematic Alcohol Use in Early Phase Psychosis Patients
NCT05365347
Recruiting
A focus of research for youth and Emerging Adults with early phase psychosis (EPP) has been cannabis use. However, this focus has led to overlooking the possible negative influence of another legal recreational drug, alcohol. Previous studies our research group has done have demonstrated that over use of alcohol reduces the effectiveness of early intervention in psychosis treatment services. These treatment services are wrap around services that address medical, and social needs of young people... Read More
Gender:
ALL
Ages:
Between 16 years and 35 years
Trial Updated:
08/21/2024
Locations: Nova Scotia Health Authority, Halifax, Nova Scotia
Conditions: Psychosis, Alcohol Use Disorder
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Restrictive Fluid Management In Liver Transplantation (REFIL)
NCT05647733
Recruiting
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial Study population: Patients with end-stage liver disease undergoing a liver transplantation not meeting any exclusion criteria. Primary endpoint: The primary feasibility endpoint is an overall recruitment rate ≥ 4 patients/month across all three participating sites. Secondary endpoint: The secondary feasibility endpoints are a protocol adherence \> 90... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: London Health Sciences Centre, London, Ontario +2 locations
Conditions: Liver Transplantation
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PATH Program for for Severely Frail or Cognitively Impaired Patients Scheduled for Cancer Surgery.
NCT06022666
Recruiting
This is a single center, non-blinded randomized control trial taking place at the Queen Elizabeth II hospital (QEII) in Nova Scotia. Patients are eligible if aged 75 and older scheduled for elective cancer surgery (proven cancer or highly suspicious cancer) and screened to have mild or greater frailty (with cognitive impairments) or moderate to greater frailty (with medical/physical conditions). Eligible participants will then be randomized to preoperative standard of care or geriatric assessmen... Read More
Gender:
ALL
Ages:
75 years and above
Trial Updated:
08/21/2024
Locations: QEII, Victoria General Hospital, Halifax, Nova Scotia
Conditions: Frailty, Oncology Problem, Cognitive Impairment
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Prehab for Lung and Esophageal Cancer
NCT06354959
Recruiting
Research indicates that individuals diagnosed with lung or esophageal cancer who enter treatment with higher functional capacities, improved body composition, and better nutrition status tend to experience better outcomes and a higher quality of life. The primary objective of a prehabilitation health coaching program is to enhance the overall health and well-being of patients before they undergo major surgery.This personalized 8-week program encompasses elements such as nutrition, smoking cessat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: Victoria General Hospital, Halifax, Nova Scotia
Conditions: Neoplasm of Lung, Neoplasms, Exercise, Surgery
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GPS Project Evaluation of the Impact of the Reorganization of Work Into a Family Medicine Group on Pharmacotherapy and Support for the Autonomy of Seniors With Major Neurocognitive Disorders
NCT04889794
Recruiting
The model of care tested in the GPS project aims to optimize pharmacotherapy for seniors undergoing cognitive assessment or suffering from major neurocognitive disorder (MCND) at home. The goal is to reduce polymedication, inappropriate medications and the treatment burden of seniors and to maintain their cognitive health, quality of life and autonomy. The intervention will include knowledge exchange sessions with nurses, pharmacists, and doctors in FMGs, and increased collaboration between thes... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/20/2024
Locations: GMF Bordeaux-Cartierville, Montréal, Quebec +1 locations
Conditions: Major Neurocognitive Disorder
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Reversal of Atrial Substrate to Prevent Atrial Fibrillation Cohort Study
NCT06249269
Recruiting
Atrial fibrillation (AF) is a major health problem, with a prevalence of 0.4-1% of the population. It results in high healthcare costs and significant morbidity, especially for patients with severe symptoms. The RASTA-AF randomized control trial (RCT) is designed to answer the following question: does vigorous treatment of AF with aggressive risk factor management plus catheter ablation reduce AF-related outcomes as compared to catheter ablation plus usual care in patients with symptomatic AF an... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: QEIIHSC, Halifax, Nova Scotia
Conditions: Atrial Fibrillation, Paroxysmal or Persistent
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Predicting IBD Treatment Outcomes With Gut Microbiome Analysis
NCT06453720
Recruiting
The goal of this prospective observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn's disease (CD), a form of inflammatory bowel disease (IBD), living in British Columbia, Canada. The main questions this study seeks to answer are: 1. Can microbiome signatures across different sample types (fecal, intestinal washings, and intestinal epithelial biopsies) predict response to therapy in CD? 2. How do microbiome profiles d... Read More
Gender:
ALL
Ages:
Between 19 years and 80 years
Trial Updated:
08/20/2024
Locations: GI Research Institute, Vancouver, British Columbia
Conditions: Inflammatory Bowel Diseases, Crohn Disease
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