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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors
Recruiting
In DESTINY-Pan-Tumor \[DP-02\], DESTINY CRC02 \[DC-02\], and DESTINY-Lung01 \[DL-01\], T-DXd demonstrated tumor response across a broad range of HER2-expressing solid tumors, particularly IHC3+ patients.
This study will use real-world data (RWD) to identify IHC3+ patients in the real world who received standard of care (SoC) and compare them with IHC3+ patients who received T-DXd in the referent trials. The tumors included are: non-small cell lung cancer \[NSCLC\], colorectal cancer \[CRC\], en... Read More
In DESTINY-Pan-Tumor \[DP-02\], DESTINY CRC02 \[DC-02\], and DESTINY-Lung01 \[DL-01\], T-DXd demonstrated tumor response across a broad range of HER2-expressing solid tumors, particularly IHC3+ patients.
This study will use real-world data (RWD) to identify IHC3+ patients in the real world who received standard of care (SoC) and compare them with IHC3+ patients who received T-DXd in the referent trials. The tumors included are: non-small cell lung cancer \[NSCLC\], colorectal cancer \[CRC\], endometrial cancer, bladder cancer, epithelial ovarian cancer, cervical cancer, pancreatic cancer, biliary tract cancers, and other tumors.
This is a real-world external control arm (ECA) study to generate evidence on the comparative effectiveness of T-DXd versus real-world (RW) SoC in adult patients with HER2 IHC3+ solid tumors who have received prior systemic treatment. HER2 IHC3+ patients who initiated 5.4mg/kg of T-DXd in the referent trials (DP-02, DC-02, and DL-01) will be compared against IHC3+ patients who received RW SoC. This will be a retrospective observational study which will use secondary real-world data and data collected in the 3 aforementioned trials.
Objectives: The primary objective of this study is to evaluate the comparative effectiveness with respect to overall survival (OS) for T-DXd vs SoC for patients with HER2 IHC3+ expressing solid tumors in two pooled cohorts: one cohort reflecting the tumors in the three referent trials (referred to as the 'tumor agnostic' cohort), consisting of patients with NSCLC, CRC, endometrial, epithelial ovarian, cervical, pancreatic, biliary tract cancers, and other tumors; and a second cohort reflecting the tumors in the DP-02 trial (referred to as 'pan tumor'), consisting of the same tumors but excluding NSCLC and CRC. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/14/2025
Locations: Research Site, Spartanburg, South Carolina +26 locations
Research Site, Spartanburg, South Carolina
Research Site, Vienna, Not set
Research Site, Liege, Not set
Research Site, London, Ontario, Not set
Research Site, Olomouc, Not set
Research Site, Copenhagen, Not set
Research Site, Caen, Not set
Research Site, Lille, Not set
Research Site, Marseille, Not set
Research Site, Nice, Not set
Research Site, Paris, Not set
Research Site, Saint-Herblain, Not set
Research Site, Berlin, Not set
Research Site, Frankfurt, Not set
Research Site, Heidelberg, Not set
Research Site, W rzburg, Not set
Research Site, Meldola, Not set
Research Site, Rome, Not set
Research Site, Porto, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Pamplona, Not set
Research Site, Valencia, Not set
Research Site, Leeds, Not set
Research Site, London, Not set
Conditions: Bladder Cancer, Biliary Tract Cancer, Cervical Cancer, Endometrial Cancer, Ovarian Cancer, Pancreatic Cancer, Colorectal Cancer, Lung Cancer, Other Tumors
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Recruiting
This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive colorectal cancer. This study will also determine what side effects happen when participants take this combination of drugs. A side effect is anything a drug does to the body besides treating your disease.
Participants in this study have colorectal cancer that has spread through the body (metastatic) and/or cannot be removed with surgery (unresect... Read More
This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive colorectal cancer. This study will also determine what side effects happen when participants take this combination of drugs. A side effect is anything a drug does to the body besides treating your disease.
Participants in this study have colorectal cancer that has spread through the body (metastatic) and/or cannot be removed with surgery (unresectable).
Participants will be assigned randomly to the tucatinib group or standard of care group. The tucatinib group will get tucatinib, trastuzumab, and mFOLFOX6. The standard of care group will get either:
* mFOLFOX6 alone,
* mFOLFOX6 with bevacizumab, or
* mFOLFOX6 with cetuximab mFOLFOX6 is a combination of multiple drugs. All of the drugs given in this study are used to treat this type of cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Palo Verde Hematology Oncology, Glendale, Arizona +388 locations
Palo Verde Hematology Oncology, Glendale, Arizona
Mayo Clinic Building - Phoenix, Phoenix, Arizona
Mayo Clinic Hospital, Phoenix, Arizona
Mayo Clinic, Scottsdale, Arizona
Pacific Cancer Medical Center Inc., Anaheim, California
Kaiser Permanente Anaheim Kraemer Medical Offices, Anaheim, California
Kaiser Permanente Baldwin Park Medical Center, Baldwin Park, California
Kaiser Permanente Bellflower Medical Offices, Bellflower, California
Kaiser Permanente Fontana Medical Center, Fontana, California
Los Angeles Hematology Oncology Medical Group, Glendale, California
Los Angeles Hematology Oncology Medical Group, Glendale, California
Kaiser Permanente South Bay Medical center, Harbor City, California
Kaiser Permanente Alton/Sand Canyon Medical Offices, Irvine, California
Los Angeles Hematology Oncology Medical Group, Los Angeles, California
USC Norris Koreatown - Medical Oncology, Los Angeles, California
Kaiser Permanente Los Angeles Medical Offices, Los Angeles, California
Keck Hospital of USC, Los Angeles, California
USC/Norris Comprehensive Cancer Center / Investigational Drug Services, Los Angeles, California
USC/Norris Comprehensive Cancer Center, Los Angeles, California
Kaiser Permanente West Los Angeles Medical Center, Los Angeles, California
USC Norris Oncology/Hematology - Newport Beach, Newport Beach, California
Kaiser Permanente Ontario Medical Center, Ontario, California
Kaiser Permanente Panorama City Medical Center, Panorama City, California
Keck Medical Center of USC Pasadena, Pasadena, California
Los Angeles Hematology Oncology Medical Group, Pasadena, California
Kaiser Permanente Riverside Medical Center, Riverside, California
Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies), San Diego, California
Kaiser Permanente Zion Medical Center, San Diego, California
Kaiser Permanente San Marcos Medical Offices, San Marcos, California
Los Angeles Hematology Oncology Medical Group, Van Nuys, California
Kaiser Permanente Woodland Hills Medical Center, Woodland Hills, California
Rocky Mountain Cancer Centers, LLP, Aurora, Colorado
Rocky Mountain Cancer Centers, LLP, Boulder, Colorado
Rocky Mountain Cancer Centers, LLP, Colorado Springs, Colorado
Rocky Mountain Cancer Centers, LLP, Denver, Colorado
Rocky Mountain Cancer Centers, LLP, Denver, Colorado
Rocky Mountain Cancer Centers, LLP, Lakewood, Colorado
Rocky Mountain Cancer Centers, LLP, Littleton, Colorado
Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado
Rocky Mountain Cancer Centers, LLP, Longmont, Colorado
Rocky Mountain Cancer Centers, LLP, Pueblo, Colorado
Rocky Mountain Cancer Centers, LLP, Thornton, Colorado
Mount Sinai Medical Center Aventura ER, Aventura, Florida
Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida
Mount Sinai Medical Center, Miami Beach, Florida
Grady Health System, Atlanta, Georgia
Grady Memorial Hospital Investigational Drug Service, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital, Atlanta, Georgia
Investigational Drug Service, Atlanta, Georgia
Winship Cancer Institute, Atlanta, Georgia
Alliance for Multispecialty Research LLC., Merriam, Kansas
Baptist Health Lexington, Lexington, Kentucky
Norton Cancer Institute - Downtown, Louisville, Kentucky
Norton Cancer Institute, Downtown, Louisville, Kentucky
Norton Hospital, Louisville, Kentucky
Norton Audubon Hospital, Louisville, Kentucky
Norton Cancer Institute, Audubon Hospital Campus, Louisville, Kentucky
Norton Brownsboro Hospital, Louisville, Kentucky
Norton Cancer Institute, Brownsboro Hospital Campus, Louisville, Kentucky
Minnesota Oncology Hematology, PA, Burnsville, Minnesota
Allina Health Cancer institute, Coon Rapids, Minnesota
Minnesota Oncology Hematology, PA, Coon Rapids, Minnesota
M Health Fairview Cancer Clinic-Edina, Edina, Minnesota
Minnesota Oncology Hematology, PA, Edina, Minnesota
Minnesota Oncology Hematology, PA, Fridley, Minnesota
Minnesota Oncology Hematology, PA, Maple Grove, Minnesota
M Health Fairview St. John's Hospital, Maplewood, Minnesota
Minnesota Oncology Hematology, PA, Maplewood, Minnesota
Allina Health Cancer Institute (Virginia Piper Cancer Institute), Minneapolis, Minnesota
Minnesota Oncology Hematology, PA, Minneapolis, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
North Memorial Health Cancer Center, Robbinsdale, Minnesota
Mayo Clinic Cancer Center Outpatient Pharmacy, Rochester, Minnesota
Mayo Clinic, Rochester, Minnesota
Metro Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota
Park Nicollet Frauenshuh Cancer Center, Saint Louis Park, Minnesota
Regulatory Location: MMCORC, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
Minnesota Oncology Hematology, PA St. Paul Cancer Center, Saint Paul, Minnesota
Minnesota Oncology Hematology, PA Cornerstone Medical Specialty Center, Woodbury, Minnesota
MSK Basking Ridge, Basking Ridge, New Jersey
MSK Monmouth, Middletown, New Jersey
MSK Bergen, Montvale, New Jersey
MSK Commack, Commack, New York
MSK Westchester, Harrison, New York
Rockefeller Outpatient Pavilion (53rd Street), New York, New York
Memorial Solan Kettering Cancer Center- Main Campus, New York, New York
MSK Nassau, Uniondale, New York
Duke University Hospital, Durham, North Carolina
Duke University Medical Center, Duke Cancer Center, Durham, North Carolina
Duke University Medical Center, Durham, North Carolina
FirstHealth Cancer Center, Pinehurst, North Carolina
FirstHealth Moore Regional Hospital, Pinehurst, North Carolina
Gabrail Cancer Center Research, Canton, Ohio
Providence Cancer Institute Newberg Clinic, Newberg, Oregon
Providence Cancer Institute Willamette Falls Clinic, Oregon City, Oregon
Northwest Cancer Specialists, P.C., Portland, Oregon
Providence Cancer Institute Franz Clinic, Portland, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Oncology and Hematology Care Clinic - Westside, Portland, Oregon
Providence St. Vincent Medical Center- Investigational Drug Services, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Northwest Cancer Specialists, P.C., Portland, Oregon
Northwest Cancer Specialists, P.C., Tigard, Oregon
UPMC Hillman Cancer Center - Beaver, Beaver, Pennsylvania
UPMC Hillman Cancer Center at Butler Health System, Butler, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health, Greensburg, Pennsylvania
UPMC Hillman Cancer Center - Pinnacle (Community Osteopathic / Medical Sciences Pavillion), Harrisburg, Pennsylvania
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health, Irwin, Pennsylvania
UPMC Hillman Cancer Center - Pinnacle (Ortenzio Cancer Center), Mechanicsburg, Pennsylvania
UPMC Hillman Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center - St Margarets, Pittsburgh, Pennsylvania
University of Pittsburgh Medical Center (UPMC)/Hillman Cancer Center, Pittsburgh, Pennsylvania
UPMC Hillman Cancer Center - Passavant (HOA), Pittsburgh, Pennsylvania
St. Clair Cancer Center Medical Oncology, Pittsburgh, Pennsylvania
UPMC Hillman Cancer Center - Washington, Washington, Pennsylvania
Avera Cancer Institute, Sioux Falls, South Dakota
Henry-Joyce Cancer Clinic, Nashville, Tennessee
The University of Texas MD Anderson Cancer Center, Houston, Texas
US Oncology Investigational Product Center (IPC), Irving, Texas
US Oncology Investigational Products Center (IPC), Irving, Texas
US Oncology Investigational Products Center(IPC), Irving, Texas
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Blacksburg, Virginia
Oncology & Hematology Associates of Southwest Virginia, Low Moor, Virginia
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care, Roanoke, Virginia
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Salem, Virginia
Oncology & Hematology Associates of Southwest Virginia, Wytheville, Virginia
Providence Regional Cancer Partnership, Everett, Washington
Providence Regional Medical Center Everett, Everett, Washington
Northwest Cancer Specialists, P.C., Vancouver, Washington
Centro de Investigacion Pergamino SA, Pergamino, Buenos Aires
Instituto Medico de la Fundacion Estudios Clinicos, Rosario, Santa FE
Hospital Britanico de Buenos Aires, Caba, Not set
Instituto Medico Especializado Alexander Fleming, Ciudad Autónoma de Buenos Aires, Not set
IONC Instituto Oncologico de Cordoba Fundacion Richardet Longo, Cordoba, Not set
CEMAIC - Centro Medico Privado, Cordoba, Not set
Chris O'Brien Lifehouse, Camperdown, New South Wales
Townsville Hospital and Health Service, Townsville, Queensland
Princess Alexandra Hospital, Woolloongabba, Queensland
St Vincent's Hospital, Fitzroy, Victoria
Alfred Health, Melbourne, Victoria
Klinikum Wels-Grieskirchen GmbH Austria, Wels, Upper Austria
Landesapotheke Salzburg, Salzburg, Not set
Uniklinikum Salzburg, Landeskrankenhaus, Salzburg, Not set
Klinikum Wels-Grieskirchen GmbH Austria, Wels, Not set
Landesklinikum Wiener Neustadt, Wiener Neustadt, Not set
Institut Jules Bordet, Anderlecht, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
UZA, Edegem, Not set
CHU HELORA - Hopital de Jolimont, Haine-Saint-Paul, Not set
Centre Hospitalier Chretien - Clinique MontLegia, Liège, Not set
Maag-,Darm- en Leverziekten AZ Turnhout, Turnhout, Not set
Oncologisch Dagziekenhuis AZ Turnhout Campus Sint-Elisabeth, Turnhout, Not set
CIONC-Centro Integrado de Oncologia de Curitiba, Curitiba, Parana
Centro Integrado de Pesquisa em Oncologia CIPO-GHC / Hospital Nossa Senhora da Conceicao, Porto Alegre, RIO Grande DO SUL
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI, Rio de Janeiro, RJ
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI, Rio de Janeiro, RJ
Hospital de Cancer de Barretos/Fundacao Pio XII, Barretos, SAO Paulo
Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho, Jau, SAO Paulo
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia., Santo Andre, SAO Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto, Sao Jose do Rio Preto, SP
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira., Sao Paulo, Not set
The Ottawa Hospital Cancer Centre, Ottawa, Ontario
Sunnybrook Research Institute, Toronto, Ontario
Mount Sinai Hospital, Toronto, Ontario
Jewish General Hospital, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Oncocentro Apys, Viña del Mar, Valparaíso
Biocenter, Concepcion, Not set
Centro de estudios clinicos SAGA, Santiago, Not set
Fujian Medical University Union Hospital, Fuzhou, Fujian
The 900th Hospital of The Chinese People's Liberation Army Joint Logistics Support Force, Fuzhou, Fujian
The First Hospital of Lanzhou University, Lanzhou, Gansu
The Sixth Affiliated hospital, Sun Yat-sen University, Guangzhou, Guangdong
Meizhou People's Hospital - Guangdong Province, Meizhou, Guangdong
Meizhou People's hospital, Meizhou, Guangdong
The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan
Hainan General Hospital, Haikou, Hainan
Affiliated Hospital of Chengde Medical University, Chengde City, Hebei
Affiliated Hospital of Chengde Medical University, Chengde, Hebei
Tangshan People's Hospital, Tangshan, Hebei
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang
Nanyang Second General Hospital, Nanyang, Henan
Henan Provincial People's Hospital, Zhengzhou, Henan
Hubei Cancer Hospital, Wuhan, Hubei
The Second Xiangya Hospital of Central South University, Changsha, Hunan
The First People's Hospital of Changzhou, Changzhou, Jiangsu
Changzhou Cancer Hospital, Changzhou, Jiangsu
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu
Xuzhou Central Hospital, Xuzhou, Jiangsu
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning
The First Hospital of China Medical University, Shenyang, Liaoning
Liaoning Cancer Hospital & Institute, Shenyang, Liaoning
Jinan Central Hospital, Jinan, Shandong
Shandong Cancer Hospital, Jinan, Shandong
LinYi Cancer Hospital, Linyi, Shandong
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai
Shanxi Province Cancer Hospital, Taiyuan, Shanxi
The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang
Beijing Cancer Hospital, Beijing, Not set
Hunan Cancer Hospital, Changsha, Not set
Army Specialty Medical Center of The Chinese People's Liberation Army, Chongqing, Not set
Shanghai General Hospital, Shanghai, Not set
Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz, Besancon Cedex, Other
Institut Sainte Catherine, Avignon cedex 9, Not set
CHU Brest Hopital Cavale Blanche, Brest, Not set
Hopital Henri Mondor, Creteil, Not set
Center Georges-Francois Leclerc, Dijon, Not set
Hopital Edouard Herriot, LYON Cedex 3, Not set
Höpital Saint-Joseph, Marseille CEDEX 8, Not set
Centre Hospitalier Universitaire Nantes-Hotel Dieu, Nantes Cedex 1, Not set
Centre Antoine Lacassagne, Nice cedex 2, Not set
Hopital Saint-Louis, Paris, Not set
Pharmacy Address:Hopital Saint-Louis, Paris, Not set
Hopital Saint-Antoine, Paris, Not set
Hopital Europeen Georges Pompidou, Paris, Not set
CHU Bordeaux Hopital Haut Leveque, Pessac, Not set
CHU Poitiers, Poitiers, Not set
CHU de Rouen, ROUEN Cedex, Not set
Institut de Cancérologie de l'Ouest - Saint-Herblain, Saint Herblain, Not set
Centre Hospitalier Universitaire Sainte-Etienne - Hopital Nord, Saint Priest En Jarez, Not set
Institut de Cancerologie Strasbourg Europe, Strasbourg, Not set
CCC Muenchen TUM, Muenchen, Bavaria
LMU Klinikum - Campus Großhadern, München, Bayern
Medizinische Hochschule Hannover (MHH), Hannover, Niedersachsen
Universitätsklinikum Leipzig, Leipzig, Sachsen
Landesdirektion Sachsen Dienststelle Leipzig, Leipzig, Saxony
Klinikum St. Marien Amberg, Amberg, Not set
Charité - Universitätsmedizin Berlin, Berlin, Not set
Apotheke Johannstadt, Dresden, Not set
Gemeinschaftspraxis Hämatologie - Onkologie, Dresden, Not set
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus, Dresden, Not set
Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Agaplesion Frankfurter Diakonie Kliniken gGmbH, Frankfurt, Not set
Agaplesion Markus Krankenhaus, Frankfurt, Not set
Hämatologisch Onkologische Praxis Eppendorf (HOPE), Hamburg, Not set
ZytoService Deutschland GmbH, Hamburg, Not set
Asklepios Kliniken Hamburg GmbH, Hamburg, Not set
Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona, Hamburg, Not set
Medizinische Hochschule Hannover (MHH), Hannover, Not set
Universitätsklinikum Leipzig, Leipzig, Not set
Klinikum rechts der Isar der TU München, Krankenhausapotheke, Muenchen, Not set
Klinikum Rechts der Isar der Technischen Universitaet Muenchen, Munchen, Not set
Klinik für Hämatologie, Onkologie und Gastroenterologie, Mönchengladbach, Not set
Klinikum rechts der Isar der Technischen Universitaet Muenchen, München, Not set
Zentrale Apotheke - Rheinland Klinikum Lukaskrankenhaus Neuss, Neuss, Not set
Universitaetsklinikum Ulm, Ulm, Not set
Athens Medical Center - Psychikon branch, Athens, Attikí
University General Hospital "Attikon", Athens, Chaidari
"University General Hospital of Heraklion Oncology Unit ", Heraklion, Crete
"Papageorgiou" General Hospital of Thessaloniki 2nd Internal Medicine/Oncology Clinic of Aristotle, Nea Efkarpia, Thessaloniki
Evgenidion Clinic Agia Trias Oncology Department, Athens, Not set
Cork University Hospital,Department of Medical Onncology, Cork, Not set
Bon Secours Hospital, Cork, Not set
St Vincents University Hospital, Dublin, Not set
Mater Misericordiae University Hospital, Dublin, Not set
Mater Private Hospital, Dublin, Not set
Beaumont Hospital, Dublin, Not set
University Hospital Waterford, Waterford, Not set
Azienda Ospedaliera Universitaria Cagliari, Monserrato, Cagliari
Farmacia AOU Cagliari - Presidio Ospedaliero ' Duilio Casula' di Monserrate, Monserrato, Cagliari
UOC Oncologia Medica - Dipartimento Onco Ematologico AORN San Giuseppe Moscati di Avellino, Avellino, Campania
IRCCS Ospedale Policlinico San Martino Farmacia, Genova, GE
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio
UOC Oncologia, Azienda Ospedaliera Cardinale Giovanni Panico, Tricase, Lecce
Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardy
lstituto Europeo di Oncologia, Milano, Lombardy
Niguarda Cancer Center Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Lombardy
UMaCA U.O.S.D. Farmacia Ospedaliera, Napoli, Naples
IRCCS Ospedale Policlinico San Martino, Genova, Other
Ospedale S Chiara Farmacia, Pisa, Other
Servizio Farmacia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona, Verona, Other
Farmacia Sperimentazioni, Reggio Emilia, RE
UOC Oncologia Medica, ARNAS GARIBALDI - PRESIDIO OSPEDALIERO NESIMA, Catania, Sicily
Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana
SODc Oncologia Medica e Clinica, AOU Careggi, Firenze, Tuscany
Istituto Oncologico Veneto - IRCCS, Padova, Veneto
Struttura Semplice Dipartimentale di Oncologia Medica e Terapia Biomolecolare Azienda Ospedaliero, Foggia, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori Farmacia, Milano, Not set
lstituto Europeo di Oncologia Servizio Farmacia, Milan, Not set
Istituto Oncologico Veneto-IRCCS Farmacia, Padova, Not set
Fondazione IRCCS Policlinico San Matteo Farmacia, Pavia, Not set
Fondazione IRCCS Policlinico San Matteo, Pavia, Not set
Farmacia UFA, Reggio Emilia, Not set
S.C Oncologia Arcispedale Santa Maria Nuova, Reggio Emilia, Not set
Farmacia degli Sperimentali Policlinico Gemelli IRCCS, Roma, Not set
ASST della Valtellina e dell'alto Lario - Presidio Ospedaliero di Sondrio, Sondrio, Not set
ASST della Valtellina e dell'alto Lario- Presidio Ospedaliero di Sondrio Farmacia, Sondrio, Not set
U.O.C. Oncologia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona, Verona, Not set
Chiba Cancer Center, Chiba-shi, Chiba-ken
National Cancer Center Hospital East, Kashiwa-shi, Chiba-ken
NHO Shikoku Cancer Center, Matsuyama-shi, Ehime-ken
National Hospital Organization Kyushu Cancer Center, Fukuoka-City, Fukuoka
Hokkaido University Hospital, Sapporo, Hokkaido
Kobe City Hospital Organization Kobe City Medical Center General Hospital, Kobe-shi, Hyōgo
Kagawa University Hospital, Kita-gun, Kagawa
St. Marianna University Hospital, Kawasaki-shi, Kanagawa
Kanagawa Cancer Center, Yokohama-shi, Kanagawa
Osaka University Hospital, Suita-shi, Osaka-fu
National Hospital Organization Osaka National Hospital, Chuo-Ku, Osaka
Osaka General Medical Center, Osaka-shi, Osaka
Kindai University Hospital, Osakasayama-shi, Osaka
Osaka Medical and Pharmaceutical University Hospital, Takatsuki-shi, Osaka
Saitama Cancer Center, Kitaadachi-gun, Saitama
National Cancer Center Hospital, Chuo-Ku, Tokyo
Cancer Institute Hospital of JFCR, Koto-ku, Tokyo
Gachon University Gil Medical Center, Incheon, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
St. Antonius Hospital, Nieuwegein, Other
Netherlands Cancer Institute, Amsterdam, Not set
Klinische Farmacie, Nieuwegein, Not set
St. Antonius Ziekenhuis - Ziekenhuis Utrecht, Utrecht, Not set
Viecuri Medisch Centrum, Venlo, Not set
Sjukehusapoteket i Bergen [Bergen Hospital Pharmacy], Bergen, Not set
Helse Bergen HF, Haukeland University Hospital, Bergen, Not set
Oslo University Hospital (OUH) - The Norwegian Radium Hospital, Oslo, Not set
Narodowy lnstytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy lnstytut Badawczy, Warszawa, Mazowieckie
Marii Sklodowskiej-Curie Panstwowy lnstytut Badawczy, Warszawa, Mazowieckie
Wojskowy Instytut Medyczny Klinika Onkologii, Warszawa, Mazowieckie
Wojskowy Instytut Medyczny, Warszawa, Mazowieckie
MRUK-MED | Sp. z.o.o Apteka szpitalna, Rzeszow, Podkarpackie
MRUK-MED | Sp. z.o.o, Rzeszow, Podkarpackie
Apteka Szpitalna Uniwersytie Centrum Kliniczne, Gdansk, Pomorskie
Przychodnia Lekarska KOMED Roman Karaszewski, Konin, Wielkopolskie
Salve Medica Apteka Szpitalna, Lodz, Not set
Hospital Garcia de Orta, Almada, Not set
Unidade Local de Saude da Guarda-Hospital Sousa Martins, Guarda, Not set
Fundacao Champalimaud, Lisboa, Not set
Centro Hospitalar Universitário de Santo Antonio,E.P.E., Porto, Not set
Narodny Onkologicky ustav II.Onkologicka Klinika LFUK a NOU, Bratislava, Not set
Hospital Duran i Reynals - Institut Catala d'Oncologia L'Hospitalet (ICO L'Hospitalet), L'Hospitalet de Llobregat, Barcelona
Clinica Universidad de Navarra, Pamplona, Navarra
CETIR Viladomat, Barcelona, Other
Complejo Hospitalario Universitario de Canarias, La Laguna, Santa CRUZ DE Tenerife
Hospital General Universitario de Alicante, Alicante, Not set
Radiology: CETIR Ascires, Barcelona, Not set
Data review: Vall d'Hebron institute of Oncology (VHIO)., Barcelona, Not set
Hospital Vall d'Hebron Unidad de Farmacia de Ensayos Clinicos Oncohematologia, Barcelona, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitari Arnau de Vilanova, Lleida, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Clínica Universidad de Navarra (Madrid), Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Malaga (Hospital Civil), Malaga, Not set
Complejo Hospitalario Universitario de Ourense, Ourense, Not set
Hospital Universitario Central de Asturias, Oviedo, Not set
Complejo Hospitalario de Navarra, Pamplona, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital General Universitario de Valencia, Valencia, Not set
Hospital Quiron Salud Zaragoza, Zaragoza, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Pharmacy:Kantonsspital Winterthur, Winterthur, Other
Zuripharm AG, Schlieren, Not set
Kantonsspital Winterthur, Winterthur, Not set
Universitatsspital Zurich - Klinik fur Medizinische Onkologie und Hamatologie USZ, Zurich, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
National Taiwan University Hospital Clinical Trial Pharmacy, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital LinKou, Taoyuan, Not set
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, Chelsea
Cambridge University Hospitals NHS Foundation Trust, Oncology Centre, Cambridge, England
The Royal Marsden Hospital, Sutton, Surrey
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, Not set
Leeds Teaching Hospitals NHS Trust, st James's Institute of Oncology, Leeds, Not set
Guy's and Saint Thomas' NHS Foundation Trust, London, Not set
The Royal Marsden Hospital - Chelsea Site, London, Not set
The Royal Marsden NHS Foundation Trust, London, Not set
Imperial College Healthcare NHS Trust, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, Not set
Conditions: Colorectal Neoplasms
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Recruiting
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease. Read Less
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
08/14/2025
Locations: Imaging Endpoints, Scottsdale, Arizona +125 locations
Imaging Endpoints, Scottsdale, Arizona
Local Institution - 1657, Anaheim, California
Local Institution - 1637, La Jolla, California
Local Institution - 1662, Pomona, California
Local Institution - 1639, Torrance, California
Local Institution - 1651, Walnut Creek, California
Local Institution - 1630, Colorado Springs, Colorado
Local Institution - 1622, Maitland, Florida
Local Institution - 1631, Maitland, Florida
Local Institution - 1618, Miami, Florida
Local Institution - 1609, Miami, Florida
Nuovida Research Center, Miami, Florida
Local Institution - 1608, Ocala, Florida
Local Institution - 1635, Orlando, Florida
Local Institution - 1612, Port Orange, Florida
Local Institution - 1661, Savannah, Georgia
Local Institution - 1655, Marrero, Louisiana
CBH Health, Gaithersburg, Maryland
Local Institution - 1638, Newton, Massachusetts
Local Institution - 1642, South Dartmouth, Massachusetts
Local Institution - 1660, Springfield, Massachusetts
Local Institution - 1620, Troy, Michigan
Local Institution - 1649, Las Vegas, Nevada
Local Institution - 1647, Middletown, New Jersey
Local Institution - 1610, Inwood, New York
Local Institution - 1656, New Windsor, New York
Local Institution - 1645, Woodmere, New York
Local Institution - 1658, Woodmere, New York
Local Institution - 1601, Monroe, North Carolina
Local Institution - 1659, Centerville, Ohio
Central States Research, Tulsa, Oklahoma
Local Institution - 1652, Columbia, South Carolina
Local Institution - 1653, Columbia, South Carolina
Local Institution - 1643, El Paso, Texas
Local Institution - 1641, Salt Lake City, Utah
Local Institution - 1646, Bennington, Vermont
Local Institution - 1644, Seattle, Washington
Local Institution - 1654, Spokane, Washington
Local Institution - 1001, La Plata, Buenos Aires
Local Institution - 1002, Mar del Plata, Buenos Aires
Local Institution - 1006, Rosario, Santa Fe
Local Institution - 1003, Buenos Aires, Not set
Local Institution - 1005, Cordoba, Not set
Local Institution - 1000, Cordoba, Not set
Local Institution - 1004, Córdoba, Not set
Local Institution - 1051, Brasília, Distrito Federal
Local Institution - 1053, Curitiba, Paraná
Local Institution - 1052, Curitiba, Paraná
Local Institution - 1054, Porto Alegre, Rio Grande Do Sul
Local Institution - 1056, Sao Paulo, SP
Local Institution - 1050, Rio De Janeiro, Not set
Local Institution - 1055, São Paulo, Not set
Local Institution - 1100, Sofia, Sofia-Grad
Local Institution - 1101, Pleven, Not set
Local Institution - 1103, Razgrad, Not set
Local Institution - 1102, Varna, Not set
Local Institution - 1153, Hamilton, Ontario
Local Institution - 1151, Toronto, Ontario
Local Institution - 1154, Toronto, Ontario
Local Institution - 1152, Whitby, Ontario
Local Institution - 1150, Montreal, Quebec
Local Institution - 1550, Zagreb, Grad Zagreb
Local Institution - 1553, Zagreb, Grad Zagreb
Local Institution - 1554, Rijeka, Not set
Local Institution - 1551, Split, Not set
Local Institution - 1552, Varazdin, Not set
Local Institution - 1200, Patras, Achaḯa
Local Institution - 1205, Athens, Attiki
Local Institution - 1202, Athens, Attiki
Local Institution - 1206, Athens, Not set
Local Institution - 1203, Athens, Not set
Local Institution - 1207, Athens, Not set
Local Institution - 1201, Ioannina, Not set
Local Institution - 1204, Thessaloniki, Not set
Local Institution - 1251, Hyderabad, Andhra Pradesh
Local Institution - 1255, Ahmedabad, Gujarat
Local Institution - 1252, Hyderabad, Telangana
Local Institution - 1254, Varanasi, Uttar Pradesh
Local Institution - 1250, Kolkata, West Bengal
Local Institution - 1256, Delhi, Not set
Local Institution - 1253, New Delhi, Not set
Local Institution - 1301, Hadano, Kanagawa
Local Institution - 1307, Kawasaki, Kanagawa
Local Institution - 1304, Sakai, Osaka
Local Institution - 1300, Karatsu-shi, Saga-Ken
Local Institution - 1303, Kanzaki-Gun Yoshinogari-Cho, Saga
Local Institution - 1305, Bunkyo-ku, Tokyo
Local Institution - 1302, Fukuoka, Not set
Local Institution - 1306, Okayama, Not set
Local Institution - 1355, Saltillo, Coahuila
Local Institution - 1356, Ciudad de México, Distrito Federal
Local Institution - 1350, Monterrey, Nuevo León
Local Institution - 1361, Mexico City, Not set
Local Institution - 1363, Mexico City, Not set
Local Institution - 1360, Mexico City, Not set
Local Institution - 1362, San Luis Potosi, Not set
Local Institution - 1352, Tlalnepantla de Baz, Not set
Local Institution - 1401, Coimbra, Not set
Local Institution - 1402, Guimaraes, Not set
Local Institution - 1404, Lisboa, Not set
Local Institution - 1403, Senhora da Hora, Not set
Local Institution - 1400, Torres Vedras, Not set
Local Institution - 1459, Bucharest, București
Local Institution - 1450, Bucuresti, București
Local Institution - 1452, Bucuresti, București
Local Institution - 1453, Bucuresti, București
Local Institution - 1454, Bucuresti, București
Local Institution - 1455, Bucuresti, București
Local Institution - 1456, Bucuresti, București
Local Institution - 1458, Bucuresti, București
Local Institution - 1451, Bucuresti, Not set
Local Institution - 1461, Constanta, Not set
Local Institution - 1457, Iasi, Not set
Local Institution - 1460, Sanpetru /Brasov, Not set
Local Institution - 1462, Sibiu, Not set
Local Institution - 1510, Getxo, Bizkaia
Local Institution - 1509, Elche (alicante), Not set
Local Institution - 1508, Madrid, Not set
Local Institution - 1505, Madrid, Not set
Local Institution - 1502, Malaga, Not set
Local Institution - 1507, Pamplona, Not set
Local Institution - 1500, Salamanca, Not set
Local Institution - 1503, Sevilla, Not set
Local Institution - 1504, Terrassa, Not set
Local Institution - 1506, Valladolid, Not set
Local Institution - 1501, Zaragoza, Not set
Conditions: Alzheimer Disease
Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
Recruiting
The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs).
The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pe... Read More
The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs).
The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pemetrexed and carboplatin) in regard to progression-free survival (PFS) and overall survival (OS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Kaiser Permanente - Oakland ( Site 0054), Oakland, California +152 locations
Kaiser Permanente - Oakland ( Site 0054), Oakland, California
Kaiser Permanente - Roseville ( Site 0055), Roseville, California
Kaiser Permanente - San Francisco ( Site 0056), San Francisco, California
Kaiser Permanente - Santa Clara ( Site 0057), Santa Clara, California
Kaiser Permanente-Kaiser Permanente ( Site 0036), Vallejo, California
Kaiser Permanente - Walnut Creek ( Site 0058), Walnut Creek, California
Mid Florida Hematology and Oncology Center ( Site 0005), Orange City, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0003), Marietta, Georgia
University of Michigan ( Site 0009), Ann Arbor, Michigan
Cox Medical Center North - Cox Medical Center/ Hematology/Medical Oncology ( Site 0051), Springfield, Missouri
Astera Cancer Care ( Site 0032), East Brunswick, New Jersey
Stony Brook University-Cancer Center ( Site 0038), Stony Brook, New York
Sanford Fargo Medical Center ( Site 0028), Fargo, North Dakota
Sanford Cancer Center ( Site 0024), Sioux Falls, South Dakota
Millennium Research & Clinical Development ( Site 0035), Houston, Texas
Clinica Adventista Belgrano-Oncology ( Site 0315), Caba., Buenos Aires
Instituto Alexander Fleming ( Site 0307), Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0304), Ciudad autónoma de Buenos Aires, Caba
Centro Privado de RMI Río Cuarto S.A. II ( Site 0310), Río Cuarto, Cordoba
Instituto de Oncología de Rosario ( Site 0301), Rosario, Santa Fe
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0303), La Rioja, Not set
Cross Cancer Institute ( Site 0201), Edmonton, Alberta
Waterloo Regional Health Network (WRHN) ( Site 0207), Kitchener, Ontario
Princess Margaret Cancer Centre ( Site 0203), Toronto, Ontario
McGill University Health Centre ( Site 0204), Montréal, Quebec
Anhui Provincial Cancer Hospital ( Site 3132), Hefei, Anhui
Beijing Cancer hospital ( Site 3100), Beijing, Beijing
Beijing Peking Union Medical College Hospital-pneumology department ( Site 3107), Beijing, Beijing
Chongqing University Cancer Hospital-Medical Oncology ( Site 3128), Chongqing, Chongqing
Fujian Cancer Hospital ( Site 3124), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University ( Site 3125), XiaMen, Fujian
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 3102), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital-Respiratory Oncology ( Site 3103), Nanning, Guangxi
Harbin Medical University Cancer Hospital ( Site 3109), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 3105), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 3121), Wuhan, Hubei
Hubei Cancer Hospital ( Site 3122), Wuhan, Hubei
The Second Xiangya Hospital of Central South University-Oncology ( Site 3104), Changsha, Hunan
Nanjing Drum Tower Hospital JiangBei International Branch Hospital ( Site 3117), Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University-Respiratory Department ( Site 3118), Suzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University ( Site 3119), Nanchang, Jiangxi
The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 3130), XI An, Shaanxi
Jinan Central Hospital ( Site 3113), Jinan, Shandong
Shandong Cancer Hospital ( Site 3112), Jinan, Shandong
Zhongshan Hospital of Fudan University ( Site 3133), Shanghai, Shanghai
Shanxi Cancer Hospital ( Site 3114), Taiyuan, Shanxi
West China Hospital, Sichuan University ( Site 3126), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 3127), Chengdu, Sichuan
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3101), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 3106), Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 3120), Wenzhou, Zhejiang
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0601), Valledupar, Cesar
IMAT S.A.S ( Site 0602), Monteria, Cordoba
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0600), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0606), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 0604), Pereira., Risaralda
Fundacion Valle del Lili- CIC-Oncology CIC ( Site 0605), Cali, Valle Del Cauca
Nouvel Hôpital Civil (NHC) ( Site 1302), Strasbourg, Alsace
Clinique Clairval ( Site 1306), Marseille, Bouches-du-Rhone
Gustave Roussy ( Site 1303), Villejuif, Ile-de-France
Hopitaux Universitaires Paris Centre-Hopital Cochin-Unité d'Oncologie Thoracique ( Site 1304), Paris, Not set
All India Institute of Medical Sciences-Department of medical oncology ( Site 3303), New Delhi, Delhi
Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3301), New Delhi, Delhi
Rajiv Gandhi Cancer Institute And Research Centre ( Site 3300), New Delhi, Delhi
Artemis hospital ( Site 3307), Gurugram, Haryana
Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute-Centre for cancer ( Site 3302), Mumbai, Maharashtra
Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1803), Milano, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1800), Milan, Lombardia
Instituto Tumori Giovanni Paolo II-SSD Oncologia Medica per la Patologia Toracica ( Site 1802), Bari, Puglia
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1804), Firenze, Toscana
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1801), Roma, Not set
Fujita Health University Hospital ( Site 3409), Toyoake, Aichi
Ehime University Hospital ( Site 3411), Toon, Ehime
National Hospital Organization Kyushu Cancer Center ( Site 3401), Fukuoka,, Fukuoka
Gunma Prefectural Cancer Center ( Site 3413), Ota, Gunma
Kanazawa University Hospital ( Site 3402), Kanazawa, Ishikawa
St. Marianna University Hospital ( Site 3415), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 3416), Yokohama, Kanagawa
Miyagi Cancer Center ( Site 3406), Natori, Miyagi
Kansai Medical University Hospital ( Site 3414), Hirakata, Osaka
Saitama Prefectural Cancer Center ( Site 3417), Kitaadachi-gun, Saitama
Shizuoka Cancer Center ( Site 3405), Sunto-gun, Shizuoka
National Cancer Center Hospital ( Site 3408), Chuo, Tokyo
Toho University Omori Medical Center ( Site 3407), Ota, Tokyo
Kyushu University Hospital ( Site 3400), Fukuoka, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 3419), Hiroshima, Not set
Niigata Cancer Center Hospital ( Site 3403), Niigata, Not set
Okayama University Hospital ( Site 3404), Okayama, Not set
Osaka International Cancer Institute ( Site 3410), Osaka, Not set
Osaka Metropolitan University Hospital ( Site 3412), Osaka, Not set
Chungbuk National University Hospital ( Site 3804), Cheongju-si, Chungbuk
National Cancer Center ( Site 3803), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 3807), Seongnam, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital ( Site 3800), Suwon-si, Kyonggi-do
Ajou University Hospital ( Site 3813), Suwon, Kyonggi-do
Pusan National University Yangsan Hospital ( Site 3802), Pusan, Kyongsangnam-do
Pusan National University Hospital ( Site 3805), Busan, Pusan-Kwangyokshi
Keimyung University Dongsan Hospital CRC room 1 ( Site 3814), Daegu, Taegu-Kwangyokshi
Chungnam national university hospital ( Site 3806), Jung-gu, Taejon-Kwangyokshi
The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3812), Seoul, Not set
Asan Medical Center ( Site 3810), Seoul, Not set
Samsung Medical Center ( Site 3811), Seoul, Not set
Korea University Guro Hospital ( Site 3808), Seoul, Not set
University Malaya Medical Centre ( Site 3507), Lembah Pantai, Kuala Lumpur
National Cancer Institute-Radiotherapy and Oncology ( Site 3504), Putrajaya, Kuala Lumpur
Hospital Tengku Ampuan Afzan ( Site 3506), Kuantan, Pahang
Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 3501), George Town, Pulau Pinang
Sarawak General Hospital-Radiotherapy Unit ( Site 3508), Kuching, Sarawak
Arké SMO S.A. de C.V. ( Site 0706), Mexico, Distrito Federal
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0700), Guadalajara, Jalisco
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0705), Monterrey, Nuevo Leon
Centro de Investigacion Clinica de Oaxaca ( Site 0704), Oaxaca de Juarez, Oaxaca
Oaxaca Site Management Organization S.C. ( Site 0701), Oaxaca, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2003), Bydgoszcz, Kujawsko-pomorskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2000), Warszawa, Mazowieckie
Bialostockie Centrum Onkologii ( Site 2010), Bialystok, Podlaskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach-II Klinika Radioterapi i Chemioterapii ( Site 2002), Gliwice, Slaskie
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2321), LHospitalet de Llobregat, Barcelona
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2322), Santiago de compostela, La Coruna
Hospital Universitario Juan Ramon Jimenez-Oncología Medica ( Site 2323), Huelva, Not set
Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2324), Sevilla, Not set
Karolinska Universitetssjukhuset Solna ( Site 2401), Stockholm, Stockholms Lan
National Cheng Kung University Hospital ( Site 3901), Tainan City, Tainan
Chi Mei Hospital - Liouying Branch ( Site 3909), Tainan City, Tainan
National Taiwan University Cancer Center (NTUCC) ( Site 3907), Taipei City, Taipei
Changhua Christian Hospital ( Site 3904), Changhua, Not set
National Taiwan University Hospital - Hsinchu branch ( Site 3900), Hsinchu, Not set
Chang Gung Memorial Hospital at Kaohsiung ( Site 3905), Kaohsiung, Not set
Far Eastern Memorial Hospital ( Site 3912), New Taipei, Not set
Taichung Veterans General Hospital-Chest ( Site 3910), Taichung, Not set
National Taiwan University Hospital-Oncology ( Site 3908), Taipei, Not set
Mackay Memorial Hospital-Chest Medicine ( Site 3902), Taipei, Not set
Taipei Medical University Hospital ( Site 3903), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 3911), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 4005), Muang, Chiang Mai
Faculty of Medicine - Khon Kaen University ( Site 4002), Muang, Khon Kaen
Faculty of Medicine Siriraj Hospital ( Site 4004), Bangkok, Krung Thep Maha Nakhon
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 4006), Dusit, Krung Thep Maha Nakhon
Ramathibodi Hospital ( Site 4001), Ratchathewi, Krung Thep Maha Nakhon
Lampang Cancer Hospital ( Site 4000), Mueang Lampang, Lampang
Songklanagarind hospital ( Site 4003), HatYai, Songkhla
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2504), Adana, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 2501), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 2505), Ankara, Not set
Ankara Bilkent Şehir Hastanesi ( Site 2500), Ankara, Not set
I.E.U. Medical Point Hastanesi-Oncology ( Site 2503), Izmir, Not set
Hanoi Oncology Hospital ( Site 4198), Hanoi, Ha Noi
K Hospital - National Cancer Hospital ( Site 4193), Hanoi, Ha Noi
National Lung Hospital-Oncology Department ( Site 4194), Hanoi, Ha Noi
Thong Nhat Hospital ( Site 4192), Tan Binh District, Ho Chi Minh
Cho Ray Hospital ( Site 4190), Ho Chi Minh, Not set
Ho Chi Minh City Oncology Hospital - Tan Phu Ward ( Site 4191), Ho Chi Minh, Not set
Tam Anh Hospital ( Site 4196), Ho Chi Minh, Not set
Conditions: Non-small Cell Lung Cancer (NSCLC)
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
Recruiting
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug.
The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM.
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug.
The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +96 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
USC/Norris Comprehensive Cancer Center, Los Angeles, California
University of California, Davis Comprehensive Cancer Center, Sacramento, California
UC San Diego Moores Cancer Center, San Diego, California
University of California San Francisco Medical Center, San Francisco, California
UCLA Department of Medicine-Hematology/Oncology, Santa Monica, California
Stanford Cancer Institute, Stanford, California
Colorado Blood Cancer Institute, Denver, Colorado
Moffitt Cancer Center, Tampa, Florida
Winship Cancer Institute, Atlanta, Georgia
IU Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana
Norton Cancer Institute, St. Matthews Campus, Louisville, Kentucky
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
University of Michigan, Ann Arbor, Michigan
Corewell Health - Lemmen-Holton Cancer Pavilion, Grand Rapids, Michigan
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York
Novant Health Cancer Institute Hematology, Charlotte, North Carolina
Novant Health Cancer Institute Hematology- Forsyth, Winston-Salem, North Carolina
University of Cincinnati Medical Center, Cincinnati, Ohio
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
Oregon Health and Science University, Portland, Oregon
University of Tennessee Medical Center, Knoxville, Tennessee
Baptist Cancer Center, Memphis, Tennessee
Henry-Joyce Cancer Clinic, Nashville, Tennessee
St. David's South Austin Medical Center, Austin, Texas
Houston Methodist Hospital Cancer Center, Houston, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Swedish Cancer Institute, Seattle, Washington
University of Washington Medical Center, Seattle, Washington
Royal Prince Alfred Hospital, Camperdown, New South Wales
Royal North Shore Hospital, St. Leonards, New South Wales
Royal Adelaide Hospital, Adelaide, South Australia
Epworth HealthCare, Richmond, Victoria
Sir Charles Gairdner Hospital, Nedlands, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Hamatologie mit Stammzelltransplantation, Hamostaseologie und medizinische Onkologie, Linz, Not set
Paracelsus Medizinischen Privatuniversitaet, Salzburg, Not set
University Hospital St. Poelten, Department of Internal Medicine I, St. Poelten, Not set
Medical University of Vienna, Wien, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
University Hospital of Antwerp, Edegem, Not set
UZ Leuven, Flemish Brabant, Not set
UZ Gent, Gent Oost-Vlaanderen, Not set
QEII Health Sciences Centre, Halifax, Not set
University Health Network - The Princess Margaret Cancer Centre, Toronto, Not set
CHU de Lille- Hopital Claude Huriez, Lille, Not set
Institut Paoli Calmettes, Marseille, Not set
CHU De Montpellier - Hopital Saint Eloi, Montpellier, Not set
Centre Hospitalier Universitaire de Nantes, Nantes, Not set
Hopital Saint Louis, Paris, Not set
Hopital Saint Antoine, Paris, Not set
Hôpital Lyon Sud, Pierre-Benite, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
CHU de Rennes, Rennes, Not set
CHU de Toulouse. IUCT Oncopole, Toulouse, Not set
Universitatsklinikum Hamburg Eppendorf, Hamburg, Not set
Universitatsklinikum Koln, Klinik I fOr lnnere Medizin, Köln, Not set
Universitatsklinikum Leipzig, Leipzig, Not set
TUM Klinikum, Rechts der Isar, Klinik und Poliklinik fur Innere Medizin III, Hamatologie und Onkologie, München, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, MI
IRCCS AOU di Bologna, Bologna, Not set
Ospedale San Raffaele, Milano, Not set
AOU Città della Salute e della Scienza Presidio Ospedaliero Molinette, Torino, Not set
Hyogo Medical University Hospital, Hyogo, Not set
Nagoya City University Hospital, Nagoya City, Not set
The University of Osaka Hospital, Osaka, Not set
Hamamatsu University Hospital, Shizuoka, Not set
Jichi Medical University Hospital, Tochigi, Not set
Juntendo University School of Medicine Juntendo Clinic, Tokyo, Not set
Japanese Red Cross Medical Center, Tokyo, Not set
Amsterdam UMC - Location vUmc, Amsterdam, Not set
University Medical Center Groningen, Groningen, Not set
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wroclaw, Not set
ICO Badalona-H.U. Germans Trias i Pujol, Badalona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital Duran i Reynals, Barcelona, Not set
Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital Universitario Ramon Y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Universitario Virgen del Rocio, Seville, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Inselspital - Universitätsspital Bern, Berne, Not set
Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
University Hospitals Bristol NHS Foundation Trust, Bristol Haematology and Oncology Centre, Bristol, Not set
University Hospital of Wales, Cardiff, Not set
Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, Not set
King's College Hospital, London, Not set
University College London Hospital, London, Not set
Newcastle Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle, Not set
Conditions: Multiple Myeloma
Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial
Recruiting
This phase II trial compares tuvusertib in combination with avelumab to tuvusertib alone to determine whether the combination therapy will lengthen the time before the cancer starts getting worse in patients with Merkel cell cancer that has not responded to previous treatment (refractory). Tuvusertib is a drug that inhibits an enzyme called ataxia telangiectasia and Rad3 related (ATR) kinase, which is an enzyme that plays a role in repair of damaged deoxyribonucleic acid (DNA) as well as tumor c... Read More
This phase II trial compares tuvusertib in combination with avelumab to tuvusertib alone to determine whether the combination therapy will lengthen the time before the cancer starts getting worse in patients with Merkel cell cancer that has not responded to previous treatment (refractory). Tuvusertib is a drug that inhibits an enzyme called ataxia telangiectasia and Rad3 related (ATR) kinase, which is an enzyme that plays a role in repair of damaged deoxyribonucleic acid (DNA) as well as tumor cell replication and survival. It may lead to tumor cell death by inhibiting ATR kinase activity. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving tuvusertib in combination with avelumab may lengthen the time before Merkel cell cancer starts getting worse compared to giving avelumab alone. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California +51 locations
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
UC San Diego Moores Cancer Center, La Jolla, California
Keck Medicine of USC Koreatown, Los Angeles, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
USC Norris Oncology/Hematology-Newport Beach, Newport Beach, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Yale University, New Haven, Connecticut
Sibley Memorial Hospital, Washington, District of Columbia
UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida
UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida
Moffitt Cancer Center - McKinley Campus, Tampa, Florida
Moffitt Cancer Center, Tampa, Florida
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Northwestern University, Chicago, Illinois
Memorial Hospital East, Shiloh, Illinois
HaysMed, Hays, Kansas
University of Kansas Cancer Center, Kansas City, Kansas
Lawrence Memorial Hospital, Lawrence, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
University Health Truman Medical Center, Kansas City, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Wake Forest University Health Sciences, Winston-Salem, North Carolina
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
University Health Network-Princess Margaret Hospital, Toronto, Ontario
Conditions: Locally Advanced Merkel Cell Carcinoma, Metastatic Merkel Cell Carcinoma, Refractory Merkel Cell Carcinoma, Unresectable Merkel Cell Carcinoma, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
Recruiting
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent.
* EC is a type of cancer that starts in the tissues inside the uterus (womb)
* pMMR indicates that certain normal proteins are present in the cancer cells
* Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery
* Recurrent means the cancer came back after surgery
Sacituzumab tirumo... Read More
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent.
* EC is a type of cancer that starts in the tissues inside the uterus (womb)
* pMMR indicates that certain normal proteins are present in the cancer cells
* Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery
* Recurrent means the cancer came back after surgery
Sacituzumab tirumotecan (also known as sac-TMT) and pembrolizumab are the study medicines. Sac-TMT is an antibody drug conjugate (ADC). An ADC attaches to specific targets on cancer cells and delivers treatment to destroy those cells.
The goal of this study is to learn if people who receive sac-TMT with pembrolizumab live longer and without the cancer getting worse compared to people who receive pembrolizumab alone. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Mount Sinai Cancer Center ( Site 6031), Miami Beach, Florida +20 locations
Mount Sinai Cancer Center ( Site 6031), Miami Beach, Florida
TRIALS 365 ( Site 6005), Shreveport, Louisiana
Miami Valley Hospital South ( Site 6014), Centerville, Ohio
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6047), Tulsa, Oklahoma
Texas Oncology - DFW ( Site 8004), Fort Worth, Texas
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0108), Mar del Plata, Buenos Aires
Fundación Respirar ( Site 0101), Buenos Aires, Caba
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0605), Montreal, Quebec
ONCOCENTRO APYS ( Site 0704), Vina del Mar, Valparaiso
Rambam Health Care Campus ( Site 2025), Haifa, Not set
Carmel Hospital ( Site 2023), Haifa, Not set
Shaare Zedek Medical Center ( Site 2020), Jerusalem, Not set
Sourasky Medical Center ( Site 2022), Tel Aviv, Not set
Keimyung University Dongsan Hospital ( Site 3105), Daegu, Taegu-Kwangyokshi
Asan Medical Center ( Site 3103), Seoul, Not set
Puerto Rico Cancer Specialists Clinical Trials ( Site 4201), San Juan, Not set
National Cancer Centre Singapore ( Site 3201), Singapore, Central Singapore
Taichung Veterans General Hospital ( Site 3703), Taichung, Not set
National Taiwan University Hospital ( Site 3701), Taipei, Not set
Mackay Memorial Hospital ( Site 3704), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 3705), Taoyuan, Not set
Conditions: Endometrial Cancer
A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Pediatric Participants With Moderate to Severe Plaque Psoriasis
Recruiting
The purpose of this pediatric study is to evaluate the drug levels, efficacy and safety of Deucravacitinib in pediatric participants aged 4 to \<18 years with moderate to severe plaque psoriasis. This study includes two cohorts; Cohort 1 (age 12 to \<18 years) and Cohort 2 (age 4 to \<12 years), with two parts; for each cohort. Part A will evaluate the drug levels of BMS-986165 to enable selection of 2 dose levels to be studied in Part B. Part B will assess the efficacy and safety of two dose le... Read More
The purpose of this pediatric study is to evaluate the drug levels, efficacy and safety of Deucravacitinib in pediatric participants aged 4 to \<18 years with moderate to severe plaque psoriasis. This study includes two cohorts; Cohort 1 (age 12 to \<18 years) and Cohort 2 (age 4 to \<12 years), with two parts; for each cohort. Part A will evaluate the drug levels of BMS-986165 to enable selection of 2 dose levels to be studied in Part B. Part B will assess the efficacy and safety of two dose levels in pediatric participants with moderate to severe plaque psoriasis. The 5-year long-term extension (LTE) period will observe the long-term safety and tolerability of deucravacitinib in pediatric participants with psoriasis who have completed Parts A or B of the study. Read Less
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
08/14/2025
Locations: Instituto de Neumonologia Y Dermatologia, Ciudad Autonoma de Buenos Aires, Buenos Aires +62 locations
Instituto de Neumonologia Y Dermatologia, Ciudad Autonoma de Buenos Aires, Buenos Aires
Psoriahue, Ciudad Autonoma de Buenos Aires, Buenos Aires
CONEXA Investigacion Clinica S.A., Buenos Aires, Not set
Hospital Italiano de Buenos Aires, Caba, Not set
Centro de Investigaciones Metabólicas (CINME), Ciudad Autónoma de Buenos Aires, Not set
Consultora Integral de Salud, Córdoba, Not set
The Skin Hospital, Darlinghurst, New South Wales
Local Institution - 0002, Westmead, New South Wales
Queensland Children's Hospital, Brisbane, Queensland
Veracity Clinical Research, Woolloongabba, Queensland
Monash Health, Clayton, Victoria
Local Institution - 0001, Melbourne, Victoria
Centro de Pesquisas da Clínica IBIS, Salvador, Bahia
Hospital Moinhos de Vento, Porto Alegre, Rio Grande Do Sul
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) - HCFMRP, Ribeirão Preto, São Paulo
Local Institution - 0083, Rio de Janeiro, Not set
Local Institution - 0067, São Paulo, Not set
Local Institution - 0010, Calgary, Alberta
Alberta Dermasurgery Centre, Edmonton, Alberta
Local Institution - 0039, Hamilton, Ontario
Lynderm Research Inc., Markham, Ontario
The Hospital for Sick Children, Toronto, Ontario
Local Institution - 0090, Calais, Not set
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand-dermatology, Dijon, Not set
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice, Not set
Local Institution - 0021, Paris, Not set
Universitätsklinikum Münster, Münster, Nordrhein-Westfalen
Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz, Rheinland-Pfalz
Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Sachsen
Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin, Not set
Kath. Kinderkrankenhaus Wilhelmstift, Hamburg, Not set
Nagoya City University Hospital, Nagoya, Aichi
Fukuoka University Hospital, Fukuoka, Jonan-Ku, Fukuoka
Local Institution - 0040, Isehara, Kanagawa
Mie University Hospital, Tsu, Mie
Teikyo University Hospital, Itabashi-ku, Tokyo
Tokyo Medical University Hospital, Shinjuku-ku, Tokyo
Nippon Life Hospital, Osaka, Not set
Local Institution - 0048, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0047, Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
RM Pharma Specialists, Mexico City, Distrito Federal
Crea de Guadalajara, Guadalajara, Jalisco
Grupo Clínico CATEI S.C., Guadalajara, Jalisco
Arké SMO S.A de C.V, Veracruz, Not set
Local Institution - 0011, Krakow, Not set
Dermoklinika Centrum Medyczne S.C. M. Kierstan, J. Narbutt, A. Lesiak, Lodz, Not set
Państwowy Instytut Medyczny MSWiA-Klinika Dermatologii, Warsaw, Not set
WroMedica, Wroclaw, Not set
Local Institution - 0080, Bucharest, București
Lotus-Med Tunari, Bucharest, București
Local Institution - 0088, Bucharest, București
Local Institution - 0081, Bucuresti, București
CCBR Clinical Research, Bucuresti, București
Spitalul clinic de urgenta pentru copii Sf. Maria, Iasi, Not set
Spitalul Clinic Judetean Mures, Targu Mures, Not set
Hospital General Universitario de Alicante-Dermatology, Alicante, Not set
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces-Dermatology, Barakaldo, Not set
Hospital Sant Joan de Déu-URC Dermatology, Esplugues de Llobregat, Not set
Hospital Universitario de Gran Canaria Doctor Negrín-Dermatología, Las Palmas De GC, Not set
Hospital Universitario 12 de Octubre-DERMATOLOGY, Madrid, Not set
Hospital Universitario La Paz-UCICEC/DERMA, Madrid, Not set
Mounts Bay Medical, Connor Downs, Not set
Conditions: Plaque Psoriasis
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Recruiting
This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or has spread to other parts of the body, it is called unresectable. These types of cancer are harder to... Read More
This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or has spread to other parts of the body, it is called unresectable. These types of cancer are harder to treat.
Participants in this study must have cancer that has come back or did not get better with treatment. Participants must have a solid tumor cancer that can't be treated with standard of care drugs.
This clinical trial uses an experimental drug called PF-08046050. PF-08046050 is a type of antibody-drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. They may also stick to some normal cells.
This study will test the safety of PF-08046050 in participants with solid tumors that are hard to treat or have spread throughout the body.
This study has 5 different study parts. Part A and Part B of the study will find out how much PF-08046050 should be given to participants. Part C will use the information from Parts A and B to see if PF-08046050 is safe and if it works to treat certain solid tumor cancers. Part D of the study, together with information from Parts A and B, will find out how much PF-08046050 should be given to participants in combination with bevacizumab. Part E will use the information from Parts A, B, and D to see if PF-08046050 is safe in combination with bevacizumab and if it works to treat a certain solid tumor. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Mayo Clinic Hospital, Phoenix, Arizona +26 locations
Mayo Clinic Hospital, Phoenix, Arizona
City of Hope, Duarte, California
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora, Colorado
University of Colorado Hospital/University of Colorado, Aurora, Colorado
Florida Cancer Specialists, Orlando, Florida
Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, Florida
Sidney Kimmel Comprehensive Cancer at Johns Hopkins, Baltimore, Maryland
Beth Israel Deaconess Medical Center, Boston, Massachusetts
START Midwest, Grand Rapids, Michigan
Mayo Clinic Cancer Center, Rochester, Minnesota
Sarah Cannon Research Institute - Pharmacy, Nashville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
The University of Texas MD Anderson Cancer Center, Houston, Texas
South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas
South Texas Accelerated Research Therapeutics Mountain Region, West Valley City, Utah
The Ottawa Hospital, Ottawa, Ontario
University Health Network, Princess Margaret Hospital, Toronto, Ontario
McGill University Health Centre, Montreal, Quebec
Institut Gustave Roussy, Villejuif Cedex, Paris
Gustave Roussy, Villejuif, Not set
Netherlands Cancer Institute, Amsterdam, Not set
Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), L'Hospitalet de Llobregat, Catalunya [cataluña]
START Madrid-CIOCC_Hospital HM Sanchinarro, Madrid, Not set
Karolinska University Hospital, Solna, Not set
ApoEx NKS, Stockholm, Not set
The University of Edinburgh, Edinburgh, Not set
Sarah Cannon Research Institute UK, London, Not set
Conditions: Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Pancreatic Ductal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small Cell Lung Carcinoma
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
Recruiting
This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating th... Read More
This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating the disease.
Participants in this study will have cancer that has spread through the body (metastatic) or spread near where it started (locally advanced).
In this study, there are 2 different groups. Participants will be assigned to a group randomly. Participants in the disitamab vedotin arm will get the study drug disitamab vedotin once every two weeks and pembrolizumab once every 6 weeks. Participants in the standard of care arm will get gemcitabine once a week for 2 weeks with either cisplatin or carboplatin once every 3 weeks. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Banner Gateway Medical Center, Gilbert, Arizona +328 locations
Banner Gateway Medical Center, Gilbert, Arizona
Banner MD Anderson Cancer Center, Gilbert, Arizona
UCLA Hematology/Oncology - Alhambra, Alhambra, California
Foothill Cardioology, Arcadia, California
Beverly Hills Multi-Specialties Practice, Beverly Hills, California
Providence Saint Joseph Medical Center, Burbank, California
UCLA Burbank Cardiology, Burbank, California
UCLA Hematology/Oncology - Burbank, Burbank, California
UCLA Calabasas Specialty Care, Calabasas, California
UCLA Encino Specialty Care (Radiology), Encino, California
UCLA Hematology/Oncology - Encino, Encino, California
Helios Clinical Research, Glendale, California
Foothill Cardiology Glendora, Glendora, California
Helios Clinical Research, Long Beach, California
UCLA Downtown Los Angeles Primary & Specialty Care, Los Angeles, California
Administrative Address: UCLA Hematology/Oncology, Los Angeles, California
UCLA Cardiovascular Center, Los Angeles, California
UCLA Hematology & Oncology Clinic, Los Angeles, California
UCLA Hematology / Oncology, Los Angeles, California
UCLA Westwood Specialty Care, Los Angeles, California
UCLA Montecito Primary & Specialty Care, Montecito, California
Pacific Cancer Care, Monterey, California
Newport Diagnostics, Newport Beach, California
Foothill Cardiology Pasadena, Pasadena, California
Southern California Heart Specialists, Pasadena, California
UCLA Porter Ranch Primary & Specialty Care, Porter Ranch, California
UCSF Center at China Basin Imaging, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Divisadero, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Post, San Francisco, California
UCSF Cancer Center MZ Phlebotomy, San Francisco, California
UCSF Mount Zion Phlebotomy, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Parnassus, San Francisco, California
UCSF Parnassus Phlebotomy, San Francisco, California
UCSF Parnassus-5 Lab, San Francisco, California
Cardiovascular Care and Prevention Center at Mission Bay, San Francisco, California
UCSF Investigational Drugs Pharmacy, San Francisco, California
UCSF Mission Bay Gateway-2 Lab, San Francisco, California
UCSF Mission Bay PCMB-5 Lab, San Francisco, California
UCSF Mission Bay Pediatric Clinical Research Center, San Francisco, California
UCSF Mission Bay Radiology and Nuclear Medicine, San Francisco, California
University of California San Francisco, San Francisco, California
University of California, San Francisco | HDFCCC - Hematopoietic malignancies, San Francisco, California
Diagnostic Medical Group of Southern California, , San Gabriel, CA, San Gabriel, California
Southern California Heart Centers, San Gabriel, California
UCLA Hematology/Oncology - San Luis Obispo, San Luis Obispo, California
Sierra Vista Regional Medical Center, San Luis Obispo, California
Helios Clinical Research, Santa Ana, California
UCLA Hematology/Oncology - Santa Barbara, Santa Barbara, California
UCLA Hematology/Oncology - Santa Monica, Santa Monica, California
UCLA Simi Valley Alamo Specialty Care, Simi Valley, California
Twin Cities Community Hospital, Templeton, California
UCLA Thousand Oaks Primary & Specialty Care, Thousand Oaks, California
UCLA Hematology/Oncology - Torrance, Torrance, California
UCLA Torrance Lomita Specialty Care, Torrance, California
UCLA Santa Clarita Primary & Specialty Care, Valencia, California
UCLA Ventura Cardiology, Ventura, California
UCLA Hematology/Oncology - Westlake, Westlake Village, California
Helios Clinical Research, Whittier, California
Greater Baltimore Medical Center, Baltimore, Maryland
M Health Fairview Ridges Cancer Clinic, Burnsville, Minnesota
M Health Fairview Cancer Clinic-Edina, Edina, Minnesota
Minnesota Oncology Hematology Pa, Edina, Minnesota
Minnesota Oncology Hematology, PA, Fridley, Minnesota
M Health Fairview Maple Grove Cancer Center, Maple Grove, Minnesota
Allina Health Cancer Institute-United(VPCI), Minneapolis, Minnesota
Hennepin Country Medical Center, Minneapolis, Minnesota
M Health Fairview University of Minnesota Investigational Drug Services, Minneapolis, Minnesota
Metro Minnesota Community Oncology Research Consortium(MMCORC), Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
M Health Fairview Lakes Medical Center, Wyoming, Minnesota
Nebraska Medicine- Bellevue Medical Center, Bellevue, Nebraska
Nebraska Medicine -Nebraska Medical Center, Omaha, Nebraska
Nebraska Medicine-Cancer Center at Village Pointe Health Center, Omaha, Nebraska
The University of Nebraska Medical Center, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Optum Care Cancer Care at Seven Hills, Las Vegas, Nevada
OptumCare Cancer center, Las Vegas, Nevada
OptumCare Cancer Center Care at Fort Apache, Las Vegas, Nevada
Icahn School of Medicine at Mount Sinai, New York, New York
Ship study drug to: Mount Sinai Hospital- Pharmacy Dept, New York, New York
ECU Health Medical Center, Greenville, North Carolina
AHN Saint Vincent Hospital, Erie, Pennsylvania
AHN Jefferson Hospital, Jefferson Hills, Pennsylvania
AHN Forbes Hospital, Monroeville, Pennsylvania
Allegheny Valley Hospital, Natrona Heights, Pennsylvania
AHN Cancer Institute - Allegheny General Hospital, Pittsburgh, Pennsylvania
AHN Cancer Institute Pharmacy, Pittsburgh, Pennsylvania
AHN West Penn Hospital, Pittsburgh, Pennsylvania
UT Southwestern Medical Center - Redbird, Dallas, Texas
University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas, Texas
University of Texas Southwestern Medical Center-Simmons Cancer Center Pharmacy, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
UT Southwestern - Simmons Cancer Center - Fort Worth, Fort Worth, Texas
UT Southwestern - Simmons Cancer Center - Richardson/Plano, Richardson, Texas
Inova Schar Cancer Institue Infusion Pharmacy, Fairfax, Virginia
Inova Schar Cancer Institute, Fairfax, Virginia
Harborview Medical Center, Seattle, Washington
Fred Hutchinson Cancer Center., Seattle, Washington
University of Washington Medical Center, Seattle, Washington
Clinica Viedma, Viedma, RIO Negro
Fundación Dr. Ruben Kowalyszyn, Viedma, RÍO Negro
Comisión Provincial de Evaluación de Proyectos de Investigación en Salud Humana (CEEPISH), Viedma, RÍO Negro
Centro de Oncologia e Investigacion de Buenos Aires (COIBA), Berazategui, Not set
Instituto Médico Especializado Alexander Fleming, Buenos Aires, Not set
Centro Medico Austral, Buenos Aire, Not set
Centro Oncologico Korben, Buenos Aire, Not set
Fundacion Cenit, Caba, Not set
Investigaciones Clinicas Moleculares (ICM), Caba, Not set
CEMAIC - Centro Medico Privado, Cordoba, Not set
Hospital Municipal de Morón. O. B. Lavignolle, Morón, Not set
Centro de Investigacion Pergamino SA, Pergamino, Not set
Comité Provincial de Bioética-Rosario, Rosario, Not set
Sanatorio Parque, Rosario, Not set
Consultorio Dr. Miguel Angel Escudero, Salta, Not set
Oncologia Salta, Salta, Not set
Centro para la Atencion Integral del paciente Oncologico, Tucuman, Not set
Concord Repatriation General Hospital, Concord, New South Wales
Saint Vincents Hospital Sydney - Human Research Ethics Committee, Darlinghurst, New South Wales
St Vincent's Clinic, Darlinghurst, New South Wales
Macquarie University Hospital, Macquarie University, New South Wales
Macquarie University, North Ryde, New South Wales
Prince of Wales Hospital, Randwick, New South Wales
North Shore Private Hospital, St Leonards, New South Wales
Mater Misericordiae - Mater Hospital Brisbane, Brisbane, Queensland
Icon Cancer Centre Chermside, Herston, Queensland
Mater Research, South Bribane, Queensland
Peninsula & South Eastern Hematology and Oncology Group (PASO), Frankston, Victoria
Austin Health, Melbourne, Victoria
South Eastern Sydney Local Health District, Caringbah, Not set
Lyell McEwin Hospital, Elizabeth Vale, Not set
Peninsula And South East Oncology, Frankston, Not set
Cabrini., Malvern, Not set
Mid North Coast Local Health District, NSW, Not set
Port Macquarie Base Hospital, Port Macquarie, Not set
Mater Cancer Care Centre, South Brisbane, Not set
Royal North Shore Hospital, St Leonards, Not set
Algemeen Ziekenhuis Maria Middelares, Gent, Not set
AZ St. Lucas, Ghent, Not set
University Hospital Ghent, Ghent, Not set
CHU de Liege Service Oncologie Medicale, Liege, Not set
CHU UCL Namur-Site de Saint Elisabeth, Namur, Not set
GZA Hospital Sint-Augustinus, Wilrijk, Not set
Centro de Oncologia da Bahia, Salvador, BA
Suporte Nutricional e Quimioterapia - PRONUTRIR, Fortaleza, Ceará
Associacao Mario Penna - Hospital Luxemburgo - NEPI Nucleo de Ensino Pesquisa e Inovacao, Belo Horizonte, MG
Hospital Sao Vicente de Paulo, Passo Fundo, RIO Grande DO SUL
Hospital Mae de Deus, Porto Alegre, RIO Grande DO SUL
Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS
Hospital Nossa Senhora da Conceicao / Grupo Hospitalar Conceicao, Porto Alegre, RS
Fundacao Doutor Amaral Carvalho, Jaú, SÃO Paulo
Hospital de Cancer de Barretos - Fundacao Pio XII, Barretos, Not set
Erasto Gaertner Hospital, CuriBba, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
University of Alberta / Cross Cancer Institute, Edmonton, Alberta
Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC), Oshawa, Ontario
Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario
Centro de Estudios Clínicos SAGA, Santiago, Not set
Centro de Investigaciones Clinicas Vina del Mar, Vina del mar, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové
Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika, Olomouc, Not set
University Hospital of Besancon, Besancon, Not set
Institut Bergonié Centre de Lutte Contre le Cancer (CLCC), Bordeaux Cedex, Not set
Centre de Lutte contre le Cancer - François Baclesse, Caen Cedex 5, Not set
Institut Paoli Calmettes, Marseille, Not set
Institut régional du Cancer de Montpellier - ICM Val d'Aurelle, MONTPELLIER Cedex 5, Not set
Pharmacy ICM Val d'Aurelle - Bat A - Rez-de-Jardin, MONTPELLIER Cedex 5, Not set
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne, Nice Cedex 2, Not set
Hopital Europeen Georges Pompidou, Paris, Not set
Hospices Civils de Lyon, Pierre Benite, Not set
Unite de Coordination de la Biologie des Essais Cliniques, Strasbourg, Not set
Institut de Cancerologie Strasbourg Europe, Strasbourg, Not set
Institut Gustave Roussy, Villejuif Cedex, Not set
Athens Medical Center, Maroussi, Attikí
Bioclinic Thessalonikis Private Clinic Single Member S.A., Thessaloniki, Kentrikí Makedonía
Metropolitan General Hospital, Cholargos, Not set
Semmelweis Egyetem Urologiai Klinika, Budapest, Not set
Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemét, Not set
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi
Nirmal Hospital Pvt Ltd, Surat, Gujarat
Cancer Trials Cork, Cork, Not set
Tallaght University Hospital, Tallaght, Not set
Cork University Hospital, Wilton, Not set
Shaare Zedek Medical Center, Jerusalem, Other
Hadassah Medical Center, Jerusalem, Other
Sheba Medical Center., Ramat Gan, Other
Emek Medical Center, Afula, Not set
Soroka Medical Center, Be'er Sheva, Not set
Rambam Health Care Campus, Hafia, Not set
Meir Medical Center, Kefar Sava, Not set
Rabin Medical Center, Petach Tikva, Not set
Kaplan Medical Center, Rehovot, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
IRCCS Istituto Tumori Giovanni Paolo II, Bari, Apulia
Azienda Ospedaliera Cardinale Giovanni Panico, Tricase, Apulia
Oncologia Medica, Ospedale Civile S. Maria delle Croci, Ravenna, Emilia-romagna
Ospedale Policlinico San Martino, Genova, Liguria
Ospedale San Raffaele, Milano, Lombardy
Istituto Clinico Humanitas-Humanitas Cancer Center, Rozzano (Milano), Lombardy
IRCCS Istituto Clinico Humanitas, Rozzano, Milano
IRCCS - Ospedale San Raffaele, Milano, Milan
Azienda Sanitaria Locale Napoli 2 Nord, Giugliano in Campania, Naples
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Other
P.O. "S. Maria Delle Grazie" - Pozzuoli - ASL Napoli Nord 2, Pozzuoli (NA), Other
ASL-AT, Ospedale Cardinal Massaia di Asti, Asti, Piemonte
SOSD Farmacia Ospedaliera, Aviano, Pordenone
Centro di Riferimento Oncologico Di Aviano, Aviano, Pordenone
AUSL Romagna - Presidio Ospedale "Umberto I" di Lugo, Lugo, Ravenna
AUSL della Romagna - Ospedale degli infermi, Faenza, RA
Azienda Ospedaliero Universitaria Careggi, Firenze, Tuscany
Azienda Ospedaliera S. Maria di Terni, Terni, Umbria
ASL Asti - Ospedale Cardinal Massaia - S.C. Farmacia Ospedaliera, Asti, Not set
ASST Cremona Farmacia Ospedaliera, Cremona, Not set
U.O. Farmacia Ospedaliera a Politiche del Farmaco Az. Osp. Universitaria Careggi, Firenze, Not set
Ospedale Policlinico San Martino Farmacia, Genova, Not set
Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale, Napoli, Not set
SC Farmacia Ospedaliera C/O Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale, Napoli, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara, Pisa, Not set
Azienda Ospedaliera Universitaria Pisana, U.O. Farmacia Ospedaliera, Pisa, Not set
Policlinico Universitario Agostino Gemelli, Roma, Not set
Centro Ricerche Cliniche Di Verona Srl, Verona, Not set
Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Not set
Hirosaki University Hospital, Hirosaki, Aomori
Ehime University Hospital, Toon, Ehime
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Fukuoka
Gunma Prefectural Cancer Center, Ota-Shi, Gunma
Kobe University Hospital, Kobe-shi, Hyogo
University of Tsukuba Hospital, Tsukuba, Ibaraki
Kagawa University Hospital, Kita-gun, Kagawa
Yokohama City University Medical Center, Yokohama, Kanagawa
Kanagawa Cancer Center, Yokohama, Kanagawa
University of Miyazaki Hospital, Miyazaki City, Miyazaki
Nara Medical University Hospital, Kashihara, Nara
Kindai University Hospital, Osakasayama-Shi, Osaka
Osaka University Hopsital, Suita-city, Osaka
Tokushima University Hospital, Tokushima-Shi, Tokushima
Keio University Hospital, Shinjuku-ku, Tokyo
Wakayama Medical University Hospital, Wakayama-shi, Wakayama
Yamaguchi University Hospital, Ube, Yamaguchi
Chiba Cancer Center, Chiba, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set
Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka, Not set
Yamagata University Hospital, Yamagata, Not set
National Cancer Center, Goyang-si, Gyeonggi-do
CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do
The Catholic University of Korea, St. Vincent's Hospital, Suwon-si, Gyeonggi-do
Jeonbuk National University Hospital, Jeonju-si, Jeollabuk-do
Chonnam National University Hwasun Hospital, Hwasun-gun, Jeollanam-do
Wonkwang University Hospital, Iksan-si, Jeonlabuk-do
Inje University Haeundae Paik Hospital, Busan, Not set
Kosin University Gospel Hospital, Busan, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center - Oncology, Seoul, Not set
Amphia Ziekenhuis, Breda, Noord-brabant
Haga Ziekenhuis, Den Haag, Zuid-holland
Antoni van Leeuwenhoek Apotheek,I-2, Amsterdam, Not set
Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, Not set
Rijnstate Hospital, Arnhem, Not set
Maastricht Universitair Medisch Centrum+, Maastricht, Not set
Radboud University Medical Center, Nijmegen, Not set
Akershus universitetssykehus HF, Lørenskog, Akershus
Avdeling for blod og kreft sykdommer. Stavanger universitetssykehus, Stavanger, Not set
Hospital Militar Central Coronel Luis Arias Schreiber, Lima, Not set
Hospital Maria Auxiliadora, Lima, Not set
Hospital de Braga, Sao Victor, Braga
Hospital de Braga, Braga, Not set
Centro Clinico Champalimaud, Lisboa, Not set
Hospital de Santa Maria - Centro Hospitalar Universitario Lisboa Norte, Lisboa, Not set
Champalimaud Clinical Center, Lisbon, Not set
Centro Hospitalar Universitário de São João, Porto, Not set
National University Hospital, Singapore, Not set
National University Cancer Institute, Singapore, Not set
National Cancer Centre Singapore, Singapore, Not set
Raffles Hospital, Singapore, Not set
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, A Coruna
Farmacia Oncologica - Unidad de Ensayos Clinicos, Santiago de Compostela, A Coruna
Hospital Universitario Badajoz, Badajoz, A Coruña [LA Coruña]
Institut Catala d' Oncologia de Badalona - Hospital Universitari Germans Trias i Pujos, Badalona, Barcelona
Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona
Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), L'Hospitalet de Llobregat, Barcelona
Hospital de Cruzes, Barakaldo, Bizkaia
Hospital Universitario Marques de Valdecilla, Santander, Cantabria
Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda, Madrid
Infanta Cristina Hospital, Badajoz, Not set
Hospital Del Mar, Barcelona, Not set
Hospital Universitari Vall D Hebron, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau- Pharmacy, Barcelona, Not set
Hospital de La Santa Creu i Sant Pau, Barcelona, Not set
Unitat d'Assajos Clinics Servei de Farmacia, L'Hospitaler De Llobregat, Not set
Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
MD Anderson Cancer Center Madrid, Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz: Servicio de Farmacia, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
HM Centro Integral Oncologico Clara Campal, Madrid, Not set
Hospital Universitario HM Sanchinarro, Madrid, Not set
Complejo Hospitalario Universitario de Ourense (CHOU), Ourense, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Consorcio Hospital General Universitario de Valencia (CHGUV), Valencia, Not set
Consorcio Hospital General Universitario de Valencia, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Ryhov Hospital, Jonkoping, Not set
Karolinska University Hospital, Stockholm, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Not set
Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung City, Not set
Kaohsiung Medical University Hospital, Kaohsiung, Not set
China Medical University Hospital - Pharmacy, Taichung, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital Clinical Trials Pharmacy, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Hospital liouying, Tainan City, Not set
Clinical Trial Pharmacy, Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Not set
National Cheng-Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Investigational Drug Service, Taipei, Not set
National Taiwan University Hospital, Taipei, Not set
NHS Greater Glasgow and Clyde (NHSGGC) - The Beatson West of Scotland Cancer Centre, Glasgow, Other
Barts Health NHS Trust Saint Bartholomews Hospital, London, Not set
Guy's and St Thomas' NHS Foundation Trust, London, Not set
Guy's and St Thomas' NHS Foundation, London, Not set
Conditions: Urothelial Carcinoma
Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma
Recruiting
This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma.
This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Concord Repatriation General Hospital, Concord, New South Wales +17 locations
Concord Repatriation General Hospital, Concord, New South Wales
Shoalhaven Cancer Care Centre, Nowra, New South Wales
Wollongong Hospital, Wollongong, New South Wales
Royal Adelaide Hospital, Adelaide, South Australia
Austin Hospital, Heidelberg, Victoria
Sir Charles Gairdner Hospital, Perth, Western Australia
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
BCCA - Vancouver, Vancouver, British Columbia
Dr. H. Bliss Murphy Cancer Centre, St. John's, Newfoundland and Labrador
QEII Health Sciences Centre, Halifax, Nova Scotia
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
London Health Sciences Centre Research Inc., London, Ontario
Ottawa Hospital Research Institute, Ottawa, Ontario
University Health Network, Toronto, Ontario
The Jewish General Hospital, Montreal, Quebec
The Research Institute of the McGill University, Montreal, Quebec
CIUSSS de l'Estrie - Centre hospitalier, Sherbrooke, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Conditions: Hodgkin Lymphoma
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Recruiting
The purpose of this study is to assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) previously treated with one next-generation hormonal agent (NHA). The primary study hypotheses are that opevesostat is superior to alternative abiraterone acetate or enzalutamide with respect to radiographic progression free survival (rPFS) per P... Read More
The purpose of this study is to assess the efficacy and safety of opevesostat plus hormone replacement therapy (HRT) compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) previously treated with one next-generation hormonal agent (NHA). The primary study hypotheses are that opevesostat is superior to alternative abiraterone acetate or enzalutamide with respect to radiographic progression free survival (rPFS) per Prostate Cancer Working Group (PCWG) Modified Response Evaluation Criteria in Solid Tumors (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and overall survival (OS), in androgen receptor ligand binding domain (AR LBD) mutation positive and negative participants. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: The University of Arizona Cancer Center - North Campus ( Site 0073), Tucson, Arizona +318 locations
The University of Arizona Cancer Center - North Campus ( Site 0073), Tucson, Arizona
UCLA Hematology/Oncology - Santa Monica ( Site 0044), Los Angeles, California
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040), Orange, California
Stanford Cancer Center ( Site 0036), Palo Alto, California
Emad Ibrahim,MD,INC. ( Site 0012), Redlands, California
Kaiser Permanente Riverside Medical Center ( Site 0099), Riverside, California
University of California Davis (UC Davis) Comprehensive Cancer Center ( Site 0114), Sacramento, California
San Francisco VA Health Care System ( Site 0093), San Francisco, California
Kaiser Permanente-Kaiser Permanente, Vallejo Medical Center, Adult Oncology ( Site 0101), Vallejo, California
University of Colorado Anschutz Medical Campus ( Site 0046), Aurora, Colorado
UCHealth Highlands Ranch Hospital ( Site 0111), Highlands Ranch, Colorado
Colorado Clinical Research ( Site 0067), Lakewood, Colorado
University of Colorado Health - Lone Tree Medical Center ( Site 0112), Lone Tree, Colorado
Yale-New Haven Hospital-Yale Cancer Center ( Site 0064), New Haven, Connecticut
MedStar Washington Hospital Center ( Site 0103), Washington, District of Columbia
Florida Cancer Specialists - South ( Site 7003), Fort Myers, Florida
Mount Sinai Cancer Center ( Site 0107), Miami Beach, Florida
Memorial Hospital West-Memorial Cancer Institute ( Site 0109), Pembroke Pines, Florida
Northside Hospital-Northside Hospital Oncology Network ( Site 0100), Atlanta, Georgia
Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0074), Elmhurst, Illinois
Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0075), Naperville, Illinois
Illinois Cancer Care ( Site 0104), Peoria, Illinois
Urology of Indiana - Carmel ( Site 0055), Carmel, Indiana
University of Kentucky Chandler Medical Center ( Site 0048), Lexington, Kentucky
Baltimore Veterans Affairs Medical Center ( Site 0069), Baltimore, Maryland
Greenebaum Comprehensive Cancer Center ( Site 0049), Baltimore, Maryland
Chesapeake Urology ( Site 0009), Towson, Maryland
Henry Ford Hospital ( Site 0015), Detroit, Michigan
Cancer and Hematology Centers of Western Michigan ( Site 0005), Grand Rapids, Michigan
HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0072), Saint Louis Park, Minnesota
HealthPartners Cancer Research Center-HealthPartners Cancer Center at Regions Hospital ( Site 0092), Saint Paul, Minnesota
St. Vincent Frontier Cancer Center-Research ( Site 0037), Billings, Montana
Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 0026), Omaha, Nebraska
OptumCare Cancer Care-Research Department ( Site 0078), Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada ( Site 0010), Las Vegas, Nevada
Rutgers Cancer Institute of New Jersey ( Site 0033), New Brunswick, New Jersey
Associated Medical Professionals - Urology ( Site 0081), Syracuse, New York
University Hospitals Cleveland Medical Center ( Site 0043), Cleveland, Ohio
Central Ohio Urology Group - Gahanna ( Site 0098), Gahanna, Ohio
Genesis Healthcare System ( Site 0102), Zanesville, Ohio
MidLantic urology ( Site 0022), Bala-Cynwyd, Pennsylvania
Fox Chase Cancer Center ( Site 0076), Philadelphia, Pennsylvania
Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083), Charleston, South Carolina
Avera Cancer Institute - Pierre ( Site 0118), Pierre, South Dakota
Avera Cancer Institute- Research ( Site 0094), Sioux Falls, South Dakota
Avera Cancer Institute - Yankton ( Site 0117), Yankton, South Dakota
The West Clinic, PLLC dba West Cancer Center ( Site 0063), Germantown, Tennessee
Texas Oncology - Central/South Texas ( Site 8003), Austin, Texas
Texas Oncology - DFW ( Site 8001), Dallas, Texas
Urology Clinics of North Texas, PLLC ( Site 0077), Dallas, Texas
Texas Oncology - Gulf Coast ( Site 8002), Houston, Texas
University of Virginia Health System ( Site 0054), Charlottesville, Virginia
Inova Schar Cancer Institute ( Site 0017), Fairfax, Virginia
Virginia Cancer Specialists (VCS) ( Site 8004), Fairfax, Virginia
VCU Health Adult Outpatient Pavillion ( Site 0061), Richmond, Virginia
Blue Ridge Cancer Care ( Site 0004), Roanoke, Virginia
Spokane Urology ( Site 0035), Spokane, Washington
Northwest Cancer Specialists (Compass Oncology) ( Site 8008), Vancouver, Washington
MEDICAL COLLEGE OF WISCONSIN ( Site 0020), Milwaukee, Wisconsin
Macquarie University-MQ Health Clinical Trials Unit ( Site 0214), Macquarie University, New South Wales
Westmead Hospital ( Site 0212), Westmead, New South Wales
Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Site 0211), Brisbane, Queensland
Monash Health ( Site 0219), Clayton, Victoria
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0210), Melbourne, Victoria
Obras Sociais Irma Dulce ( Site 0255), Salvador, Bahia
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0256), Fortaleza, Ceara
Hospital Santa Rita de Cassia ( Site 0271), Vitória, Espirito Santo
Hospital São Domingos ( Site 0258), Sao Luis, Maranhao
Hospital Mario Penna ( Site 0264), Belo Horizonte, Minas Gerais
Universidade Federal do Triangulo Mineiro - Hospital de Clinicas ( Site 0262), Uberaba, Minas Gerais
ICTRIALS Pesquisa e Desenvolvimento ( Site 0274), Curitiba, Parana
Hospital Universitário Evangélico Mackenzie ( Site 0252), Curitiba, Parana
Hospital São Lucas da PUCRS ( Site 0270), Porto Alegre, Rio Grande Do Sul
Clínica de Neoplasias Litoral ( Site 0269), Itajaí, Santa Catarina
Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0251), Bragança Paulista, Sao Paulo
Hospital de Base de São José do Rio Preto ( Site 0275), São José do Rio Preto, Sao Paulo
Instituto do Câncer Brasil - Unidade Taubaté ( Site 0263), Taubaté, Sao Paulo
Hospital Paulistano ( Site 0259), Sao Paulo, Not set
The Ottawa Hospital - General Campus ( Site 0286), Ottawa, Ontario
Sunnybrook Research Institute ( Site 0285), Toronto, Ontario
Centre Hospitalier de l'Université de Montréal ( Site 0276), Montréal, Quebec
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0277), Quebec City, Quebec
CIDO SpA-Oncology ( Site 0302), Temuco, Araucania
Clinica Universidad Catolica del Maule-Oncology ( Site 0306), Talca, Maule
FALP ( Site 0303), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0304), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0301), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0305), Viña del Mar, Valparaiso
The Second Hospital Of Anhui Medical University ( Site 1633), Hefei, Anhui
Peking University First Hospital-Urology ( Site 1602), Beijing, Beijing
Beijing Cancer hospital-Urinary Surgery ( Site 1620), Beijing, Beijing
First Medical Center of Chinese PLA General Hospital ( Site 1601), Beijing, Beijing
Beijing Cancer Hospital ( Site 1623), Beijing, Beijing
Chongqing University Cancer Hospital ( Site 1603), Chongqing, Chongqing
Southwest Hospital of Third Military Medical University ( Site 1645), Chongqing, Chongqing
The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 1639), Fuzhou, Fujian
The first affiliated hospital of Guangzhou medical university ( Site 1637), Guangzhou, Guangdong
Sun Yat-sen University Cancer Center-Urology Surgery ( Site 1638), Guangzhou, Guangdong
Tongji Hospital Tongji Medical,Science & Technology ( Site 1632), Wuhan, Hubei
The Central Hospital of Wuhan ( Site 1635), Wuhan, Hubei
Hubei Cancer Hospital-Urinary surgery ( Site 1631), Wuhan, Hubei
Hunan Cancer Hospital ( Site 1630), Changsha, Hunan
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 1615), NanJing, Jiangsu
Nantong Tumor Hospital-Urology ( Site 1609), Nantong, Jiangsu
Wuxi People's Hospital ( Site 1612), Wuxi, Jiangsu
The First Affiliated Hospital of Xi'an Jiaotong University-Oncology department ( Site 1618), XI An, Shaanxi
The Second Affiliated Hospital of Xi'an Jiaotong University-Oncology Department ( Site 1619), Xi'an, Shaanxi
Yantai Yuhuangding Hospital ( Site 1622), Yantai, Shandong
Renji Hosp Shanghai Jiaotong U School of Med ( Site 1624), Shanghai, Shanghai
Huadong Hospital Affiliated to Fudan University-Urology ( Site 1613), Shanghai, Shanghai
West China Hospital, Sichuan University-Urology Surgery ( Site 1642), Cheng Du, Sichuan
Nanchong Central Hospital-urology ( Site 1647), Nanchong, Sichuan
The Second Hospital of Tianjin Medical University ( Site 1616), Tianjin, Tianjin
Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 1644), Urumqi, Xinjiang
Yunnan Province Cancer Hospital ( Site 1643), Kunming, Yunnan
Zhejiang Provincial People's Hospital-Urology ( Site 1641), Hangzhou, Zhejiang
The First Hospital of Jiaxing-urology ( Site 1605), Jiaxing, Zhejiang
Ningbo First Hospital-Urology ( Site 1608), Ningbo, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University ( Site 1604), Wenzhou, Zhejiang
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0327), Valledupar, Cesar
IMAT S.A.S ( Site 0329), Monteria, Cordoba
Los Cobos Medical Center ( Site 0336), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0326), Bogota, Distrito Capital De Bogota
Fundación Cardiovascular de Colombia ( Site 0328), Piedecuesta, Santander
Fundación Valle del Lili ( Site 0330), Cali, Valle Del Cauca
Clínica Imbanaco S.A.S ( Site 0334), Cali, Valle Del Cauca
CIMCA-Hemato-Oncology ( Site 0380), San José, San Jose
Hospital Metropolitano - Sede Lindora-Metropolitano Research Institute Sede Lindora ( Site 0379), Santa Ana, San Jose
Onco Tech, S.A. ( Site 0376), San Jose, Not set
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0403), Brno, Brno-mesto
Fakultni Nemocnice u sv. Anny v Brne-Onkologicko-chirurgicke oddeleni ( Site 0404), Brno, Jihomoravsky Kraj
Krajská nemocnice Liberec-Department of Urology ( Site 0407), Liberec, Liberecky Kraj
Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0401), Praha, Praha 5
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0405), Olomouc, Not set
Vseobecna fakultni nemocnice v Praze ( Site 0406), Praha 2, Not set
East-Tallinn Central Hospital ( Site 1528), Tallinn, Harjumaa
North Estonia Medical Centre Foundation ( Site 1526), Tallinn, Harjumaa
Tartu University Hospital-Radiotherapy and oncology ( Site 1527), Tartu, Tartumaa
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0451), Strasbourg, Alsace
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0461), Bordeaux, Aquitaine
CHU-BREST Cavale Blanche ( Site 0456), Brest, Finistere
Ramsay Santé - Clinical La Croix Du Sud ( Site 0460), Quint-Fonsegrives, Haute-Garonne
Hôpital Foch ( Site 0455), Suresnes, Hauts-de-Seine
Centre Bourgogne ( Site 0464), Lille, Nord-Pas-de-Calais
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0454), Clermont-Ferrand, Puy-de-Dome
CENTRE LEON BERARD ( Site 0459), Lyon Cedex08, Rhone-Alpes
Gustave Roussy ( Site 0452), Villejuif, Val-de-Marne
Sainte Catherine Institut du Cancer Avignon Provence ( Site 0458), Avignon, Vaucluse
Groupe Hospitalier Paris Saint Joseph ( Site 0465), Paris, Not set
Universitaetsklinikum Freiburg-Klinik für Urologie ( Site 0506), Freiburg, Baden-Wurttemberg
Universitaetsklinikum Heidelberg ( Site 0531), Heidelberg, Baden-Wurttemberg
Studienpraxis Urologie ( Site 0529), Nürtingen, Baden-Wurttemberg
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0521), Munich, Bayern
Caritas-Krankenhaus St. Josef-Klinik fuer Urologie ( Site 0523), Regensburg, Bayern
Universitätsklinikum Marburg-Comprehensive Cancer Center ( Site 0510), Marburg, Hessen
Universitätsmedizin Göttingen - Georg-August-Universität-Klinik für Urologie ( Site 0527), Göttingen, Niedersachsen
Marien-Krankenhaus ( Site 0515), Bergisch Gladbach, Nordrhein-Westfalen
Universitaetsklinikum Koeln ( Site 0518), Köln, Nordrhein-Westfalen
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Urologie ( Site 0528), Dresden, Sachsen
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0504), Berlin, Not set
Vivantes Klinikum Am Urban ( Site 0512), Berlin, Not set
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 0553), Patras, Achaia
Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 0551), Athens, Attiki
ATTIKON GENERAL UNIVERSITY HOSPITAL-2nd Dep. of Int. Medicine. Research Unit & Diabetes Center ( Site 0552), Chaidari, Attiki
Private Practice- Dr. Rixci Augusto Lenin Ramírez ( Site 0577), Ciudad de Guatemala, Not set
MEDI-K ( Site 0576), Guatemala, Not set
CELAN,S.A ( Site 0579), Guatemala, Not set
INTEGRA Cancer Institute-Oncology ( Site 0578), Guatemala, Not set
Sanatorio Nuestra Senora del Pilar ( Site 0580), Guatemala, Not set
Hong Kong Integrated Oncology Centre ( Site 0603), Central, Not set
Queen Mary Hospital ( Site 0602), Hong Kong, Not set
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás C ( Site 0630), Miskolc, Borsod-Abauj-Zemplen
Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0636), Salgótarján, Nograd
Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0631), Budapest, Pest
Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0632), Debrecen, Not set
St. Vincent's University Hospital ( Site 0652), Dublin 04, Dublin
Tallaght University Hospital ( Site 0651), Dublin, Not set
Emek Medical Center ( Site 0680), Afula, Not set
Rambam Health Care Campus-Oncology Division ( Site 0676), Haifa, Not set
Shaare Zedek Medical Center ( Site 0679), Jerusalem, Not set
Hadassah Medical Center ( Site 0683), Jerusalem, Not set
Meir Medical Center. ( Site 0682), Kfar Saba, Not set
Rabin Medical Center ( Site 0678), Petah Tikva, Not set
Sheba Medical Center ( Site 0677), Ramat Gan, Not set
Sourasky Medical Center ( Site 0681), Tel Aviv, Not set
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 1454), Meldola, Emilia-Romagna
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1452), Milan, Lombardia
Ospedale Cannizzaro ( Site 1455), Catania, Not set
Azienda Ospedaliero Universitaria Policlinico Riuniti di Foggia ( Site 1456), Foggia, Not set
Ospedale San Raffaele-Oncologia Medica ( Site 1451), Milano, Not set
Azienda Ospedaliera Santa Maria Terni ( Site 1458), Terni, Not set
Toho University Sakura Medical Center ( Site 0730), Sakura, Chiba
University of Fukui Hospital ( Site 0735), Eiheiji-cho,Yoshida-gun, Fukui
Hospital of the University of Occupational and Environmental Health, Japan ( Site 0746), Kitakyushu, Fukuoka
Sapporo Medical University Hospital ( Site 0726), Sapporo, Hokkaido
Hokkaido University Hospital ( Site 0756), Sapporo, Hokkaido
Kobe University Hospital ( Site 0741), Kobe, Hyogo
Kanazawa Medical University Hospital ( Site 0734), Uchinada, Ishikawa
Kagawa University Hospital ( Site 0744), Kita, Kagawa
Yokohama City University Medical Center ( Site 0733), Yokohama, Kanagawa
Mie University Hospital ( Site 0737), Tsu, Mie
National Hospital Organization Nagasaki Medical Center ( Site 0748), Ōmura, Nagasaki
Nara Medical University Hospital ( Site 0742), Kashihara, Nara
Nanbu Tokushukai Hospital ( Site 0755), Shimajiri, Okinawa
Kansai Medical University Hospital ( Site 0739), Hirakata, Osaka
Bell Land General Hospital ( Site 0740), Sakai, Osaka
The University of Osaka Hospital ( Site 0738), Suita, Osaka
Saga-Ken Medical Centre Koseikan ( Site 0747), Saga-shi, Saga
Nihon University Itabashi Hospital ( Site 0732), Itabashiku, Tokyo
The Jikei University Hospital ( Site 0731), Minato, Tokyo
Akita University Hospital ( Site 0728), Akita, Not set
Kyushu University Hospital ( Site 0745), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 0758), Fukushima, Not set
Gifu University Hospital ( Site 0736), Gifu, Not set
Hiroshima University Hospital ( Site 0743), Hiroshima, Not set
Kagoshima University Hospital ( Site 0754), Kagoshima, Not set
National Hospital Organization Kumamoto Medical Center ( Site 0749), Kumamoto, Not set
Miyazaki Prefectural Miyazaki Hospital ( Site 0752), Miyazaki, Not set
University of Miyazaki Hospital ( Site 0751), Miyazaki, Not set
Nagano Municipal Hospital ( Site 0757), Nagano, Not set
National Hospital Organization Oita Medical Center ( Site 0750), Oita, Not set
National Cancer Center-Center for Urologic Cancer ( Site 1254), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital-Urology ( Site 1253), Seongnam, Kyonggi-do
Kyungpook National University Chilgok Hospital-Urology ( Site 1252), Buk-gu, Kyongsangbuk-do
Pusan National University Yangsan Hospital ( Site 1256), Pusan, Kyongsangnam-do
Seoul National University Hospital-Urology ( Site 1251), Seoul, Not set
The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 1255), Seoul, Not set
Liepaja Regional Hospital ( Site 1553), Liepaja, Not set
Pauls Stradins Clinical Univeristy Hospital-Urological department ( Site 1551), Riga, Not set
Hospital of Lithuanian University of Health Sciences Kauno klinikos ( Site 1576), Kaunas, Kauno Apskritis
National Cancer Institute ( Site 1577), Vilnius, Vilniaus Miestas
Hospital Sultan Ismail ( Site 0905), Johor Bahru, Johor
University Malaya Medical Centre ( Site 0902), Lembah Pantai, Kuala Lumpur
Sarawak General Hospital-Radiotherapy Unit ( Site 0901), Kuching, Sarawak
National Cancer Institute ( Site 0904), Putrajaya, Wilayah Persekutuan Putrajaya
Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 0903), Kuala Lumpur, Not set
Health Pharma Professional Research S.A. de C.V: ( Site 0929), Ciudad de México, Distrito Federal
Higiea Oncologia ( Site 0938), Ciudad de México, Distrito Federal
Quemex Medical and Research ( Site 0937), Tlalpan, Distrito Federal
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0928), Guadalajara, Jalisco
Filios Alta Medicina ( Site 0931), Monterrey, Nuevo Leon
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0932), Monterrey, Nuevo Leon
Eukarya Pharmasite S.C. ( Site 0939), Monterrey, Nuevo Leon
Centro de Investigacion Clinica de Oaxaca ( Site 0934), Oaxaca de Juarez, Oaxaca
Dunedin Hospital ( Site 1032), Dunedin, Otago
Auckland City Hospital ( Site 1033), Auckland, Not set
Aliada-Oncologìa ( Site 1055), Lima, Not set
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1052), Lima, Not set
Oncosalud-Clinical Research ( Site 1057), Lima, Not set
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1054), Lima, Not set
Hospital de Cascais Doutor José de Almeida ( Site 1158), Alcabideche, Lisboa
Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 1156), Vila Nova de Gaia, Porto
Unidade Local de Saude de Braga - Hospital de Braga ( Site 1151), Braga, Not set
Hospital CUF - Tejo ( Site 1157), Lisboa, Not set
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 1153), Lisboa, Not set
Unidade Local de Saude de Santo António - Hospital Santo António ( Site 1152), Porto, Not set
Advance Urology and Laparoscopic Center ( Site 1178), Ponce, Not set
Ad-Vance Medical Research-Research ( Site 1177), Ponce, Not set
Pan American Center for Oncology Trials - Ciudadela ( Site 1176), San Juan, Not set
Spitalul Universitar de Urgență Elias ( Site 1504), București, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 1503), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL ( Site 1502), Florești, Cluj
Centrul de Oncologie "Sfântul Nectarie" ( Site 1501), Craiova, Dolj
National University Hospital ( Site 1201), Singapore, Central Singapore
National Cancer Centre Singapore ( Site 1202), Singapore, Central Singapore
Singapore General Hospital ( Site 1204), Singapore, Central Singapore
Tan Tock Seng Hospital-Medical Oncology ( Site 1203), Singapore, Central Singapore
UROEXAM ( Site 1479), Nitra, Nitriansky Kraj
Privatna Urologicka Ambulancia ( Site 1478), Trencin, Trenciansky Kraj
CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE-Clinical Trials Unit ( Site 1230), Port Elizabeth, Eastern Cape
Wits Clinical Research ( Site 1234), Johannesburg, Gauteng
Wilgers Oncology Centre ( Site 1232), Pretoria, Gauteng
Curo Oncology. ( Site 1237), Pretoria, Gauteng
LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 1236), Pretoria, Gauteng
Cape Town Oncology Trials ( Site 1233), Cape Town, Western Cape
Hospital Universitari Parc Tauli-oncologia ( Site 1282), Sabadell, Barcelona
HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 1284), Barcelona, Cataluna
Institut Català d'Oncologia (ICO) - Girona ( Site 1285), Girona, Gerona
Complexo Hospitalario Universitario A Coruna ( Site 1288), A Coruna, La Coruna
Hospital Insular de Gran Canaria-Oncology ( Site 1280), Las Palmas de Gran Canaria, Las Palmas
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 1283), Pozuelo de Alarcon, Madrid
Hospital Universitario de Burgos-Oncología ( Site 1281), Burgos, Not set
Hospital Quirón Málaga ( Site 1286), Malaga, Not set
Karolinska Universitetssjukhuset Solna ( Site 1302), Stockholm, Stockholms Lan
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1301), Uppsala, Uppsala Lan
Chi Mei Medical Center ( Site 1336), Tainan City, Tainan
Kaohsiung Veterans General Hospital ( Site 1337), Kaohsiung, Not set
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 1331), Kaohsiung, Not set
China Medical University Hospital-Department of Urology ( Site 1335), Taichung, Not set
Taichung Veterans General Hospital ( Site 1338), Taichung, Not set
Taipei Veterans General Hospital ( Site 1332), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 1334), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 1353), Muang, Chiang Mai
Faculty of Medicine - Khon Kaen University ( Site 1351), Muang, Khon Kaen
Chulalongkorn University ( Site 1355), Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital ( Site 1356), Bangkok, Krung Thep Maha Nakhon
Songklanagarind hospital ( Site 1352), Hatyai, Songkhla
Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1379), Adana, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1376), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1377), Ankara, Not set
Koc Universitesi Hastanesi ( Site 1384), Istanbul, Not set
T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training ( Site 1381), Istanbul, Not set
Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1383), Istanbul, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1378), Istanbul, Not set
Ege Universitesi Hastanesi-Medical Oncology ( Site 1380), Izmir, Not set
Samsun Medical Park Hastanesi-medical oncology ( Site 1382), Samsun, Not set
Addenbrooke's Hospital ( Site 1426), Cambridge, Cambridgeshire
Royal Derby Hospital ( Site 1431), Derby, Derbyshire
Torbay Hospital ( Site 1429), Torquay, Devon
Mount Vernon Cancer Centre ( Site 1440), Northwood, England
The Royal Cornwall Hospital ( Site 1430), Truro, England
The Beatson West of Scotland Cancer Centre ( Site 1428), Glasgow, Glasgow City
Charing Cross Hospital-Oncology Research ( Site 1434), London, Hammersmith And Fulham
University College London Hospital ( Site 1437), London, London, City Of
Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials ( Site 1435), London, London, City Of
St. George's Hospital-Oncology ( Site 1441), London, London, City Of
GenesisCare - Oxford ( Site 1442), Oxford, Oxfordshire
GenesisCare - Windsor ( Site 1443), Windsor, Windsor And Maidenhead
The Christie NHS Foundation Trust ( Site 1436), Manchester, Not set
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms
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