Neuromodulation Parameter Efficacy
NCT04933370
Recruiting
The objective of this study is to determine the efficacy of neuromodulation using various stimulation paradigms in the treatment of several disorders including chronic pain.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/06/2024
Locations: University of Calgary, Calgary, Alberta
Conditions: Chronic Pain
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Occipital Nerve Stimulation in Trigeminal Autonomic Cephalgias
NCT04937010
Recruiting
The objective of this study is to determine the efficacy of occipital nerve stimulation (ONS) in the treatment of chronic trigeminal autonomic cephalalgias (TACs).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/06/2024
Locations: University of Calgary, Calgary, Alberta
Conditions: Trigeminal Autonomic Cephalgia
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Management of Sleeve Gastrectomy Failure Using Single-anastomosis Metabolic Surgery
NCT05242835
Recruiting
Sleeve gastrectomy (SG) has become the most commonly performed weight loss surgery, accounting for 60% of all bariatric operations worldwide. While technically easier with less side-effects and nutritional risks than other operations, SG is also associated with a higher risk of failure (20 to 40%). In such case, the most effective option consists in adding an intestinal bypass called the Biliopancreatic Diversion with Duodenal Switch (BPD-DS). This surgery is, however, technically challenging an... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/06/2024
Locations: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, Quebec
Conditions: Obesity, Obesity, Morbid
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Single-Sided Deafness in the Medicare Population
NCT05250414
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of cochlear implantation in adults 65 years of age and older.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/06/2024
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa +2 locations
Conditions: Hearing Loss, Unilateral
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Increased Early Pain Relief by Adding Vertebroplasty to SBRT
NCT05317026
Recruiting
The goal of treating metastases is to preserve stability and neurological function while reducing pain. The actual standard of care is stereotaxic body radiation therapy (SBRT) alone in non-surgical patients. The added value of vertebroplasty to SBRT is not well documented in the literature, nor whether performing vertebroplasty before radiotherapy treatment leads to a reduction in the rate of fractures and post-SBRT pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: CHUM, Montréal, Quebec +1 locations
Conditions: Spine Metastases, Radiation Therapy, Pain
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MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
NCT05487612
Recruiting
MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS). It is designed to ultimately address the emerging effectiveness of MiECC systems in the light of modern perfusion practice worldwide. The primary hypothesis is that MiECC, as compared to conventional CPB (cCPB), reduces the proportion of patients experiencing serious perfusion-related posto... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/06/2024
Locations: Perfusion Services University Health Network, Toronto General Hospital, Toronto, Not set +11 locations
Conditions: Coronary Artery Disease, Aortic Valve Stenosis, Extracorporeal Circulation; Complications
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ABTECT - Maintenance
NCT05535946
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: University of Alabama -Birmingham, Birmingham, Alabama +553 locations
Conditions: Ulcerative Colitis
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Thulium Fiber Laser (TFL) Versus Holmium MOSES Laser for Ureteroscopic Management of Kidney Stones
NCT05598645
Recruiting
This study aims to compare the efficacy and safety of both types of lasers, Holmium MOSES and TFL, in management of kidney stones requiring treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario
Conditions: Kidney Stone
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Effectiveness of Empagliflozin Added to Automated Insulin Delivery (AID) Systems in Adults With Type 1 Diabetes With Sub-optimal Glycemic Outcomes
NCT06021145
Recruiting
The goal of this 26-week multicenter, randomized, parallel, placebo-controlled trial is to test the effectiveness of empagliflozin use in conjunction with automated insulin delivery (AID) to improve glucose control in individuals with type 1 diabetes who do not meet target recommendations for time in range (3.9-10.0 mmol/L). The main question it aims to answer is: - Will use of empagliflozin (2.5 mg/day) increase time spent in the target range of 3.9 to 10.0 mmol/L compared to placebo for indiv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: McGill University Health Centre, Montreal, Quebec
Conditions: Type 1 Diabetes
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Quantitative Sensory Testing and Central Sensitization in Endometriosis
NCT06215937
Recruiting
Endometriosis is a gynecologic condition where there is growth of endometrial-like tissue outside the uterus, leading to severe pelvic pain. Despite conventional treatment, many patients experience persistent pelvic pain due to central sensitization (CS), where the central nervous system amplifies pain signals. Quantitative Sensory Testing (QST) enables objective testing of CS. However, there are several patient-reported questionnaires that have shown promising potential as subjective proxies of... Read More
Gender:
FEMALE
Ages:
Between 19 years and 49 years
Trial Updated:
08/06/2024
Locations: BC Women's Hospital + Health Centre, Vancouver, British Columbia
Conditions: Endometriosis, Pain
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Slim Sheath 22F Holmium Laser Enucleation of the Prostate (HoLEP) vs 26 F Sheath HoLEP for BPH: RCT
NCT06546865
Recruiting
Holmium laser enucleation of the prostate (HoLEP) is routinely performed with 24F, 26F, and 28F laser scopes. Proponents of larger caliber scopes suggest that the larger scope size allows for improved visualization, hemostasis, and operative efficiencies. Proponents of a smaller scope diameter suggest that by eliminating the need for pre-HoLEP urethral dilation to accommodate a larger scope. It has also been proposed that a smaller caliber scope is less traumatic to the urethra resulting in lowe... Read More
Gender:
MALE
Ages:
50 years and above
Trial Updated:
08/06/2024
Locations: Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario
Conditions: Benign Prostatic Hyperplasia
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Brexpiprazole Treatment for Bipolar I Depression
NCT04569448
Recruiting
Bipolar disorder (BD) is a frequent and lifelong recurrent mood disorder with treatment-resistant depressive episodes. Importantly, depressive symptoms and cognitive decline are major determinants of functionality and quality of life in this clinical population. There is robust evidence that individuals with BD have neurocognitive deficits (especially in memory and executive functioning domains) compared to the healthy population. These deficits are present in all mood states and can greatly aff... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/05/2024
Locations: McMaster University, Hamilton, Ontario +2 locations
Conditions: Bipolar Depression
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