All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Physical Task Demands of Caregivers Working in a Long-Term Care Facility

NCT06534203

Recruiting

Providing care to residents and patients significantly contributes to work-related injuries among healthcare personnel, particularly those responsible for transferring and handling residents, who face a higher risk of injury due to the physical demands of their work and other environmental factors. The purpose of this project is to better understand the daily work requirements, identify their physical demands, and assess injury risk of caregivers. Data will be collected using a new pen-and-pape... Read More

Gender:

ALL

Ages:

19 years and above

Trial Updated:

07/29/2024

Locations: Université de Moncton, Moncton, New Brunswick

Conditions: Work Related Musculoskeletal Injuries (WRMSIs)

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Exploring Empathy and Compassion Using Digital Narratives

NCT04881084

Recruiting

Stories of suffering and struggle are shared continuously through digital formats such as internet videos, news stories, social marketing, and fundraising campaigns. Digital stories are often created and shared to generate awareness about a problem, impart knowledge on contemporary issues, or promote compassion. The practice of sharing critical life events and insights provided by these experiences are valuable for tellers and the listeners alike for catharsis, healing, reconciliation, and connectiveness. Portrayals of mental suffering are a matter of cultural and social interest as new media products become available to the public. Studies published since the 1990s overwhelmingly conclude that formal media depictions are biased, promoting the stereotype that people who suffer emotionally are mentally ill, dangerous, violent, or insane. Various agencies, organizations, and corporations are actively working to provide alternative stories/narratives to mainstream media by means of video testimonials in social marketing and fundraising campaigns and, ultimately, by taking advantage of the Internet. The impact of this work is under-researched. However, preliminary evaluations of social marketing campaigns report mixed results and raise questions about their effectiveness. As well, the first-person narrative prepared digitally and shared online is also providing alternative narratives to mainstream media stories. People are increasingly using digital videos to share their stories, viewing this as an opportunity to understand their emotions and thoughts, come to terms with disgrace around sensitive, personal issues and marginalization while providing hope and encouragement to others. This proposed study focuses on the process of creating digital narratives/stories, especially stories of mental and emotional suffering, and their impact in terms of inciting empathy, compassion, and good citizenship among viewers. Read Less

Gender:

ALL

Ages:

Between 18 years and 35 years

Trial Updated:

07/25/2024

Locations: McGill University, Montreal, Quebec

Conditions: Mental Disorders, Severe, Mental Illness, Stigma, Social, Compassion, Empathy

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Treatment to Promote Self-regulation in Children With Autism Spectrum Disorder

NCT05235919

Recruiting

This study will evaluate the feasibility of repetitive Transcranial Magnetic Stimulation (rTMS) in Autism Spectrum Disorder (ASD) with self-regulation impairment. Baseline and follow-up participant visits will include behavioral assessments of self-regulation and magnetic resonance imaging (MRI) to determine neurophysiological outcomes before and after rTMS treatment.

Gender:

ALL

Ages:

Between 9 years and 18 years

Trial Updated:

07/25/2024

Locations: Bloorivew Research Institute, Toronto, Ontario

Conditions: Autism Spectrum Disorder, Self-Regulation, Emotion

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Tele-rehabilitation in Chronic Respiratory Disease: an Observational Cohort Study

NCT05820776

Recruiting

Pulmonary rehabilitation is a program that helps people with lung disease improve their function. It uses exercise, education, and self-management strategies to improve physical ability and quality of life. Because some people are unable to visit West Park Healthcare Centre, we established a remote supervised pulmonary rehabilitation program that patients can access via an electronic device (computer, tablet or smart phone). Regular quality assurance is necessary to ensure that the program is ef... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/25/2024

Locations: West Park Healthcare Centre, Toronto, Ontario

Conditions: Chronic Respiratory Disease

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The Effects of the GOLO for Life® Plan With Release Supplement on Glycemic Control and Weight in Overweight and Obese Adults With Prediabetes or Type 2 Diabetes

NCT05844644

Recruiting

The objective of this study is to investigate the efficacy and safety of the GOLO for Life® Plan (G4LP) and Release supplementation on glycemic control and weight in overweight and obese adults with Prediabetes or Type 2 Diabetes. The change in glycemic control from baseline at Days 90 and 180 following the G4LP and supplementation with Release will be assessed. Additionally, the safety and tolerability of the G4LP and Release supplementation will be measured by the occurrence of and/or changes... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

07/25/2024

Locations: One Retreat Wellness, Lasalle, Ontario +1 locations

Conditions: Type 2 Diabetes, Obese, Overweight, Prediabetes

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Harry Potter as a Novel Educational Paradigm to Improve Mental Wellness in Children: A Prospective Trial

NCT04770168

Recruiting

School-based mental health literacy interventions have been shown to reduce and/or prevent suicidal ideation and attempts. Most programs to date include an adapted version of Cognitive Behavioural Therapy (CBT) - the gold standard treatment for youth and adult mood and anxiety disorders. CBT teaches youth about the relationship between their thoughts, feelings, and behaviours, and provides strategies for managing distress. However, there is no established standard mental health literacy curriculum in Ontario. The investigators developed a school-based mental health literacy program that uses the third book in the Harry Potter series ('Harry Potter and the Prisoner of Azkaban') to teach students how to cope with distress through CBT skills. This study will determine whether the Harry Potter-based mental health literacy curriculum diminishes suicidality in students. The study will also determine whether the curriculum decreases depression and anxiety symptoms and improves well-being. The 3-month intervention is a manual-based curriculum which teaches CBT skills in English class. The website includes video and text-based onboarding to train teachers on all the lessons. Youth complete online exercises for each unit and teachers follow a manual with checklists to preserve high fidelity and standardization of core learning. Participating classes will be randomized in 1:1 fashion to receive the curriculum in the fall (\~Oct-Dec) or the winter (\~Feb-Apr). The study will use a stepped-wedge design to introduce the curriculum to classes sequentially testing whether students who receive it in fall will improve at mid-year and those in winter will catch up by year-end. The winter group is included as a "maturational" control to account for changes over the school year that are independent of the intervention and so that order effects of curriculum delivery can be tested. For this design, questionnaires will be administered four times throughout the school year (once before and after each semester), and once more the following year to measure duration of response. At each timepoint, subjects will complete validated questionnaires about suicide attempts and self-harm, anxiety, depression, well-being, and health services usage. Students may also choose to participate in focus groups to collect qualitative data on their experience with the curriculum. With additional consent (Ontario youth only), we will also collect aggregate lists of the Ontario Health Insurance Plan (OHIP) numbers for participating students. These will be provided to the Institute of Clinical Evaluative Sciences (ICES) who will identify sex, age and pre-existing healthcare utilization matched controls from regions that do not adopt the curriculum. Read Less

Gender:

ALL

Ages:

Between 11 years and 18 years

Trial Updated:

07/24/2024

Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario

Conditions: Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide Attempt

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Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

NCT02227251

Recruiting

A multicenter, open-label Phase 2b study of selinexor (KPT-330) in participants with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who have no therapeutic options of demonstrated clinical benefit.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2024

Locations: UACC Arizona, Tucson, Arizona +175 locations

UACC Arizona, Tucson, Arizona

University of California San Francisco, San Francisco, California

University of California Los Angeles (UCLA), Santa Monica, California

Boca Raton Cancer Research Medical Center, Plantation, Florida

University of Chicago, Chicago, Illinois

Robert H. Lurie Comprehensive Cancer Center/Northwestern University, Chicago, Illinois

Norton Cancer Institute, Louisville, Kentucky

Dana Farber Cancer Institute, Boston, Massachusetts

Tufts Medical Center, Boston, Massachusetts

Lahey Clinic, Burlington, Massachusetts

University of Massachusetts Medical School, Worcester, Massachusetts

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey

Clinical Research Alliance, Lake Success, New York

New York Presbyterian Hospital/ Cornell Medical College, New York, New York

Stony Brook University Hospital, Stony Brook, New York

Gabrail Cancer Center, Canton, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

University Hospitals Seidman Cancer Center, Cleveland, Ohio

University of Oklahoma, Oklahoma City, Oklahoma

Greenville Hospital System, Greenville, South Carolina

MD Anderson, Houston, Texas

Swedish Cancer Institute, Seattle, Washington

Virginia Mason Hospital & Medical Center, Seattle, Washington

St. Vincent's Hospital Sydney, Darlinghurst, New South Wales

Liverpool Hospital, Ingham Institute of Medical Research, Liverpool, New South Wales

Calvary Mater Newcastle Hospital, Waratah, New South Wales

Icon Cancer Care, South Brisbane, Queensland

Royal Adelaide Hospital, Adelaide, South Australia

Ashford Cancer Centre, Kurralta Park, South Australia

Monash Medical Centre, Clayton, Victoria

Epworth Hospital, East Melbourne, Victoria

St. Vincent's Melbourne, Fitzroy, Victoria

The Alfred Hospital, Melbourne, Victoria

Fiona Stanley Hospital, Murdoch, Western Australia

Medical University of Graz, Graz, Not set

Medizinische Universität Innsbruck für Innere Medizin, Innsbruck, Not set

LKH Leoben Department for Haemato-Oncology, Leoben, Not set

Akh Linz Innere Med III - Zentrum für Hämatologie und med. Onkologie, Linz, Not set

Krankenhaus Barmherzigen Schwestern Linz, Linz, Not set

Krankenhaus der Elisabethinen Linz GmbH, Linz, Not set

Uni. Klinik für Innere Medizin III Universitätsklinikum der PMU LKH Salzburg, Salzburg, Not set

Medical University of Vienna (MUW) Department of Medicine I, Vienna, Not set

Univ. General Hospital Hietzing, Vienna, Not set

Ziekenhuis Netwerk Antwerpen, Antwerpen, Not set

AZ Sint-Jan, Bruges, Not set

Institut Jules Bordet, Brussels, Not set

Cliniques Universitaires Saint-Luc, Brussels, Not set

UZ Gent, Gent, Not set

CH Jolimont, La Louviere, Not set

AZ Delta, Roeselare, Not set

H-Hartziekenhuis Roeselare-Menen, Roeselare, Not set

University Hospital for Active Treatment Dr. Georgi Stranski, Pleven, Not set

University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD, Sofia, Not set

Specialized Hospital for Active Treatment of Haematological Diseases EAD, Sofia, Not set

Princess Margaret Cancer Centre, Toronto, Ontario

Sir Mortimer B Davis Jewish General Hospital/McGill University, Montreal, Quebec

CHU Lyon Sud, Pierre-Bénite, Lyon

Centre Hospitalier Universitaire Henri Mondor, Créteil, Not set

Unite Hemopathies Lymphoides Chu Henri Mondor, Créteil, Not set

Chu Dijon-Bourgogne - Hematologie Clinique, Dijon, Not set

Hospitalier de la Rochelle-Ré-Aunis, La Rochelle, Not set

CHRU de Lille - Hopital Claude-Huriez, Lille, Not set

Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes, Marseille, Not set

CHU Montpellier, Montpellier, Not set

Hostpial Saint Louis - CIRCO (Centre d'Investigations et de Recherche Clinique en Oncologie), Paris, Not set

Hôpital Necker Service d'Hématologie Adult, Paris, Not set

Pitié-Salpêtrière Hospital, Paris, Not set

Centre Henri Becquerel, Rouen, Not set

Uniklinik Aachen Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation, Aachen, Not set

HELIOS Klinikum Bad Saarow, Bad Saarow, Not set

Charite Universitatsmedizin Berlin (Benjamin Franklin Campus), Berlin, Not set

Charite Universitatsmedizin Berlin (Virchow Campus), Berlin, Not set

Ev. Diakonie-Krankenhaus gGmbH, Bremen, Not set

Gemeinschaftspraxis Haematologie and Onkologie-Dresden, Dresden, Not set

Martin-Luther-University Halle-Wittenberg Department of Oncology, Halle, Not set

Medizinische Hochschule, Hannover, Not set

Universität Heidelberg Medizinische Klinik V Hämatologie, Onkologie und Rheumatologie, Heidelberg, Not set

Klinikum Kempten Klinik für Innere Medizin III - Hämatologie, Onkologie und Palliativmedizin, Koln, Not set

Klinikum Leverkusen, Leverkusen, Not set

Klinikum Ludwigshafen, Ludwigshafen, Not set

Rotkreuzklinikum München, Muenchen, Not set

Klinikum Nürnberg Nord, Nuernberg, Not set

Haematology Department and HCT Unit G.Papanicolaou Hospital, Exochi, Thessaloniki

Hematology Clinic,General Hospital of Athens,G. Gennimatos, Athens, Not set

National & Kapodistrian University of Athens, Laiko General Hospital, Athens, Not set

Hematology Department Laiko General Hospital, Athens, Not set

Second Depth of Internal Medicine, Attiko University Hospital, Athens, Not set

National & Kapodistrian University of Athens, Attiko University Hospital, Chaidari, Not set

Department of clinical hematology ,university hospital Ioannina, Ioánnina, Not set

University of Patras Medical School, Patras, Not set

Semmelweis Egyetem Általános Orvosi Kar, Budapest, Not set

Országos Onkológiai Intézet "A" Belgyógyászati Onkológiai Osztály, Budapest, Not set

Semmelweis University Department of Medicine and Oncology, Budapest, Not set

Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár, Not set

Pécsi Tudományegyetem, ÁOK, I. számú Belgyógyászati Klinika, Pécs, Not set

Veszprém Megyei Csolnoky Ferenc Kórház, Veszprém, Not set

CSolnoky ferenc Hospital, Veszprém, Not set

Regional Cancer Centre, IGIMS, Patna, Bihar

SRM Institutes for Medical Science, Vadapalani, Chennai

Rajiv Gandhi Cancer Hospital, New Delhi, Delhi

Regional Cancer Centre, Thiruvananthapuram, Kerala

Prince Aly Khan Hospital, Mumbai, Maharashtra

Jaslok Hospital and Research Centre, Mumbai, Maharashtra

Deenanath Mangeshkar Hospital, Pune, Maharashtra

Institute of Medical Sciences & SUM Hospital, Bhubaneswar, Odisha

Dayanand Medical College and Hospital, Ludhiāna, Punjab

Cancer Institute (WIA), Chennai, Tamil Nadu

Saveetha Medical College Hospital, Chennai, Tamil Nadu

G. Kuppu Swamy Naidu Hospital, Coimbatore, Tamil Nadu

Meenakshi Mission Hospital & Research Centre, Madurai, Tamil Nadu

King George's Medical University (KGMU), Lucknow, Uttar Pradesh

Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal

Netaji Subhas Chandra Bose Cancer Research Hospital, Kolkata, West Bengal

TATA Memorial Centre, Kolkata, West Bengal

Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata, West Bengal

IRCH, All India Institute of Medical Sciences, Delhi, Not set

Dr. B.R.A. Institute Rotary Cancer Hospital All India Institute of Medical Sciences, New Delhi, Not set

Hematology-Soroka, Beer Sheva, Not set

Rambam Healthcare Campus, Haifa, Not set

Wolfson MC, Holon, Not set

Hadassah Medical Center, Jerusalem, Not set

Rabin Medical Center, Petach Tikva, Not set

Assuta Medical Center, Tel Aviv, Not set

TLV Sorasky Medical Center, Tel Aviv, Not set

Sheba Medical Center, Tel Hashomer, Not set

Instituto di Ematologia Seragnoli Pad 8 Universita di Bologna, Bologna, Not set

SODc Ematologica ,AOU Careggi, Florence, Not set

AOU Maggiore della Carità SCDU Ematologia, Florence, Not set

Hematology-Oncology & Stem Cell Transplantation Unit, National Cancer Institute, Fondazione 'G. Pascale', IRCCS, Naples, Not set

SCDU Ematologia, Division of Hematology, Dept. of Translational Medicine, Universita del Piemonte Orientale, Novara, Not set

Fondazione Policlinico Universitario A. Gemelli, Rome, Not set

Azienda Ospedaliero-Universitaria Senese, Siena, Not set

Città della Salute e della Scienza di Torino, Torino, Not set

VUMc (Vrije Universiteit Amsterdam), Amsterdam, Not set

LUMC (leidse universitair medisch centrum), Leiden, Not set

North Shore Hospital, Auckland, Not set

Christchurch Hospital, Christchurch, Not set

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza, Wrocław, Radeckiego

Szpitale Wojewódzkie w Gdyni, Gdyńskie Centrum onkologii, Gdynia, Not set

MCM (Małopolskie Centrum Medyczne), Krakow, Not set

Wojewodzki Szpital Specjalistyczny w Legnicy, Legnica, Not set

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, Lublin, Not set

Hematology Department St John's Cancer Centre, Lublin, Not set

Samodzielny Publiczny Zakład Opieki Zdrowotnej Ministerstwa, Olsztyn, Not set

Instytut Hematologii i Transfuzjologii, Warszawa, Not set

Centrum Onkologii- Insytut Im. Marii Skłodowskiej-Curie Klinika Nowotworow Ukladu Chlonnego, Warszawa, Not set

Maria Sklodowska Curie National Research Institute, Warszawa, Not set

Memorial Provincial Specialist Hospital in Lodz, Łódź, Not set

Institut za onkologiju i radiologiju Srbije, Belgrade, Not set

Klinicko Bolnick Centar Zemun Odeljenje hematologije, Belgrade, Not set

Klinički centar Srbije Klinika za hematologiju, Belgrade, Not set

Kliničko bolnički centar Zvezdara, Belgrade, Not set

Klinički centar Niš Klinika za hematologiju, Nis, Not set

Institut za onkologiju Vojvodine, Sremska Kamenica, Not set

Hospitla Universitari Germans Trias i Pujol - ICO, Badalona, Not set

Hospital University Vall d'Hebron, Barcelona, Not set

Hospital Clinic i Provincial de Barcelona, Barcelona, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital de Son Llàtzer, Palma de Mallorca, Not set

Clínica Universidad De Navarra, Pamplona, Not set

Hospital Universitario de Salamanca, Salamanca, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

Gloucestershire Royal Hospital, Gloucester, Gloucestershire

Southampton University Hospital, Southampton, Hampshire

Royal Marsden Hospital, Sutton, London

Northwick Park Hospital, Harrow, Middlesex

Leeds Teaching Hospitals NHS Trust, Leeds, Yorkshire

Addenbrooke's Hospital Cambridge, Cambridge, Not set

Royal Liverpool University Hospital, Liverpool, Not set

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, Not set

King's College Hospital, London, Not set

Princess Royal University Hospital (PRUH), London, Not set

Guy's and St Thomas' NHS Foundation Trust, London, Not set

The Christie NHS Foundation Trust, Manchester, Not set

Oxford University Hospitals NHS Trust Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford, Not set

Derriford Hospital, Plymouth, Not set

Conditions: Diffuse Large B-cell Lymphoma

Learn More ›

MCID and PASS for Acute Pain and Quality of Recovery After Orthopedic Surgery

NCT04811209

Recruiting

This study seeks to define what constitutes an MCID and a PASS in patients undergoing a variety of elective major orthopedic surgery.

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

07/23/2024

Locations: Toronto Western Hopspital, Toronto, Ontario

Conditions: Pain Management

Learn More ›

Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy

NCT05753618

Recruiting

The goal of this randomized, pragmatic clinical trial is to evaluate the omission of granulocyte colony-stimulating factors (G-CSF) in breast cancer patients receiving paclitaxel portion of dose-dense adriamycin-cyclophosphamide and paclitaxel (DD-AC/T) chemotherapy. Participants will be randomized to either take G-CSF while on the paclitaxel portion of DD-AC/T chemotherapy or to omit G-CSF while on the paclitaxel portion of DD-AC/T chemotherapy.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2024

Locations: The Ottawa Hospital Cancer Centre, Ottawa, Ontario

Conditions: Early-stage Breast Cancer

Learn More ›

Emotion and Memory in Chronic Neuropathic Pain

NCT06518421

Recruiting

Chronic pain affects one in four Canadians, leading to severe personal and societal costs. Over 70% of chronic pain patients report memory difficulties and fear having unexpected pain. Abnormalities in brain structures associated with emotion and memory, including the hippocampus and amygdala, can be affected by chronic pain. Understanding the relationship between chronic pain, structural brain changes, and cognitive functioning will lead to improved diagnosis, treatment, and outcomes in chronic... Read More

Gender:

ALL

Ages:

Between 35 years and 60 years

Trial Updated:

07/23/2024

Locations: Toronto Western Hospital, Toronto, Ontario

Conditions: Trigeminal Neuralgia, Facial Pain

Learn More ›

Hypobaric L5-S1 Study

NCT06526156

Recruiting

Patients going through total hip or knee replacement (arthroplasty) have to be put under spinal anesthesia to prevent them from feeling any pain during surgery. Spinal anesthesia means having a small needle inserted between the bones of the lower lumbar spine (vertebrae). The choice of space used is decided by the anesthesiologist in charge of patient care. The space between these bones is often narrowed by arthritis or other age-related degenerative spine disease in patients having total hip or knee replacement surgery. The lowest L5-S1 (Lumbar 5- Sacral 1) space is the largest one and often least affected by arthritis, which makes it the easiest option. Despite this, it is not currently the most common space used for spinal anesthesia, because it is hard to find by palpation (feeling the bones through the skin), and because there is concern that local anesthetic will not always spread up high enough from this lowest space, which is needed for a successful spinal anesthesia. How far it spreads depends on the amount (dose) and density of local anesthetic given. There are two types of local anesthetic: one called isobaric, which has the same density as CSF (Cerebro-Spinal Fluid), and another called hypobaric, which has lower density than CSF. Isobaric local anesthetic spreads evenly throughout the CSF irrespective of patient positioning. However, a larger dose is required to achieve adequate anesthesia for surgery. Using larger doses, leads to a very long duration of sensory and motor block, far in excess of that required for surgical completion which leads to a slower recovery from anesthesia. Hypobaric local anesthetic, on the other hand, floats in CSF like oil on water. This allows anesthesiologists to use a smaller dose while still being sure that it will spread high enough to achieve adequate anesthesia for surgery. The smaller doses in turn allow for faster recovery of normal movement and feeling in the legs of patients after surgery. It has been observed that all of these dilemma can be solved by: 1. Using ultrasound imaging to find and mark the space, and 2. Injecting hypobaric local anesthetic. The goal of this observational study is to determine the success rate of spinal anesthesia with a lower dose of hypobaric bupivacaine injected into the L5-S1 space, when done on total hip or knee arthroplasty patients at Toronto Western Hospital. Read Less

Gender:

ALL

Ages:

20 years and above

Trial Updated:

07/23/2024

Locations: Toronto Western Hospital, Toronto, Ontario

Conditions: Anesthesia, Anesthesia, Local

Learn More ›

Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI

NCT04848636

Recruiting

Chronic kidney disease (CKD) is prevalent worldwide and affects around 10% of people living in developed health economies. As the kidney loses its function in patients with CKD, the kidneys are unable to filter toxins out of the blood as efficiently as those of healthy individuals. Arguably, sodium (salt) is the most relevant toxin in CKD and can build up in the kidneys of patients with CKD. Salt build-up has also been found to occur in the heart muscle tissue and could drive the development of scarring of the heart muscle tissue which contributes to heart failure. Using sodium magnetic resonance imaging (MRI), we would like to measure the levels of salt in the heart muscle tissue. We will examine whether the heart muscle tissue has high salt levels, and if so, whether this relates to any heart defects. A conventional proton MRI will be done to measure heart function. The MRI images of healthy volunteers, CKD patients, and those on hemodialysis will be analyzed for levels of salt and the findings will then be compared to the cardiac biomarkers (proteins or enzymes that are released into the blood when the heart is damaged or stressed) and fibrosis (scarring) measured from each patient's proton MRI images to establish a possible correlation. This research has the potential to precede additional studies that may investigate the effect of diuretics (a drug that increases the production of urine) on the heart muscle tissue of CKD patients. Using sodium magnetic resonance imaging (MRI), it is possible to measure the sodium content in the cardiac tissue of patients with kidney disease. In this research study, it will be investigated whether the elevated levels of sodium in patients with kidney disease is also present in their hearts, and if so, whether this relates to cardiac abnormalities. Cardiac sodium MRI images of healthy volunteers, hemodialysis patients, and CKD patients will be analyzed for sodium content. This sodium information will then be compared to the biomarkers of cardiac function and fibrosis measured from each patient's proton MRI images in order to establish a possible correlation. This research has the potential to precede additional studies that may investigate the effect of diuretics on the cardiac tissue of kidney disease patients. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/22/2024

Locations: Victoria Hospital, London, Ontario

Conditions: Chronic Kidney Diseases, Dialysis; Complications, Sodium Retention

Learn More ›