All Clinical Trials in Canada

A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata

NCT07133308

Recruiting

This study evaluates the safety and effectiveness of deuruxolitinib in adolescents aged 12 to less than 18 years who have 50% or greater scalp hair loss.

Gender:

ALL

Ages:

Between 12 years and 17 years

Trial Updated:

08/13/2025

Locations: Total Skin And Beauty Dermatology Center, Birmingham, Alabama +21 locations

Conditions: Alopecia Areata

Learn More ›

Alpha Radiation Emitters Device for the Treatment of Pancreatic Cancer Emitters With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer

NCT06698458

Recruiting

This is a multi-center clinical study enrolling up to 30 participants (15 patients in each cohort). The primary objective of the study is to evaluate the safety of Alpha DaRT in combination with chemotherapy, based on the cumulative incidence rate, severity and outcome of device related AEs. Classification of AEs will be done according to CTCAE V5. The secondary objectives of the study are to: * Assess efficacy of the Alpha DaRT sources in combination with chemotherapy, determined by overall an... Read More

Gender:

ALL

Ages:

Between 18 years and 120 years

Trial Updated:

08/13/2025

Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +15 locations

Conditions: Pancreatic Cancer, Pancreatic Adenocarcinoma, Metastatic Pancreatic Cancer

Learn More ›

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

NCT05243797

Recruiting

This is a multicenter, randomized, open-label, Phase 3 study in participants with newly diagnosed multiple myeloma to evaluate the benefits of teclistamab in combination with lenalidomide and teclistamab alone versus lenalidomide alone as maintenance therapy after autologous stem cell transplant.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/13/2025

Locations: The University of Arizona Cancer Center, Phoenix, Arizona +207 locations

The University of Arizona Cancer Center, Phoenix, Arizona

University of California-Davis Cancer Center, Sacramento, California

University of California, San Diego (UCSD) Medical Center, San Diego, California

University of Colorado Hospital, Aurora, Colorado

Colorado Blood Cancer Institute, Denver, Colorado

Yale New Haven Hospital, New Haven, Connecticut

Christiana Care, Newark, Delaware

Blood & Marrow Transplant Center, Florida Hospital Medical Group, Orlando, Florida

Moffitt at Memorial Healthcare System, Tampa, Florida

University of Illinois Medical Center at Chicago, Chicago, Illinois

Greenebaum Cancer Center UM of MD, Baltimore, Maryland

John Hopkins, Baltimore, Maryland

Tufts Medical Center, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Boston, Massachusetts

Karmanos Cancer Institute, Detroit, Michigan

Montefiore Medical Cente, Bronx, New York

Mount Sinai Medical Center - 2, New York, New York

Levine Cancer Institute, Charlotte, North Carolina

Duke University, Durham, North Carolina

East Carolina University, Greenville, North Carolina

University of Cincinnati, Cincinnati, Ohio

Seidman Cancer Center-University Hospitals Cleveland Medical Center, Cleveland, Ohio

Ohio State Medical Center, James Cancer Center, Columbus, Ohio

Lehigh Valley Health Network, Allentown, Pennsylvania

Penn State Hershey Medical Center, Hershey, Pennsylvania

Abramson Cancer Center University of Pennsylvania Medical Center, Philadelphia, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Medical University of South Carolina (MUSC), Charleston, South Carolina

Gibbs Cancer Center, Spartanburg, South Carolina

Vanderbilt University, Nashville, Tennessee

Baylor College of Medicine Center for Cell and Gene Therapy, Houston, Texas

LDS Hospital/ Intermountain Healthcare, Salt Lake City, Utah

Virginia Oncology Associates, Norfolk, Virginia

St Vincent HSHS (Green Bay Oncology), Green Bay, Wisconsin

University of Wisconsin Hospital and Clinics, Madison, Wisconsin

Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin

Hospital Italiano, Buenos Aires, Not set

Hospital Privado, Córdoba, Not set

Sanatorio Britanico Rosario, Rosario, Not set

Sunshine Coast Health, Birtinya, Queensland

Flinders Medical Centre, Adelaide, Not set

Townsville University Hospital, Douglas, Not set

Barwon Health University Hospital Geelong Andrew Love Cancer Centre, Geelong, Not set

Alfred Hospital, Melbourne, Not set

Austin Health, Melbourne, Not set

Calvary Mater Hospital, Newcastle, Not set

Sunshine Coast Health, Sunshine Coast, Not set

Concord Repatriation General Hospital, Sydney, Not set

Royal North Shore Hospital, Sydney, Not set

Landeskrankenhaus, Feldkirch, Feldkirch, Not set

Medizinische Universitaet Innsbruck, Innsbruck, Not set

University Hospital Krems/Donau, Krems, Not set

Kepler Universitätsklinikum Med Campus III, Linz, Not set

Ordensklinikum Linz GmbH, Linz, Not set

Uniklinikum Salzburg, Salzburg, Not set

Clinic Ottakring, Vienna, Not set

LKH Hochsteiermark, Vienna, Not set

Jessa Ziekenhuis, Hasselt, Not set

Department of Hematology, CH Jolimont, La Louvière, Not set

Algemeen Ziekenhuis Delta, Leuven, Not set

University Hospital Leuven, Leuven, Not set

Centre hospitalier universitaire de Liege, Liège, Not set

Hospital Mãe de Deus - Centro Integrado de Oncologia, Porto Alegre, Not set

Hospital Santa Rita, Porto Alegre, Not set

Instituto Americas de Ensino,Pesquisa e Inovação, Rio de Janeiro, Not set

IDOR- Instituto D'or de pesquisa. Av. São Rafael, Salvador, Not set

A Real e Benemérita Associação Portuguesa de Beneficência, São Paulo, Not set

Clínica Medica São Germano,Grupo Oncoclínicas Pesquisa Clínica, São Paulo, Not set

Departamento de Oncologia Clínica AC Camargo Cancer Center, São Paulo, Not set

Grupo Oncoclínicas Pesquisa Clínica, São Paulo, Not set

Hcor, Associacao Siria, São Paulo, Not set

Hemocentro UNICAMP, Universidade Estadual de Campinas, São Paulo, Not set

Hospital das Clínicas da Universidade de São Paulo, São Paulo, Not set

Hospital Paulistano, Centro de Pesquisa Clinica R. Martiniano de Carvalho, São Paulo, Not set

Onco Star, São Paulo, Not set

Universidade Federal de São Paulo - Hospital São Paulo, São Paulo, Not set

Cross Cancer Institute, Edmonton, Not set

QEII Health Sciences Centre, Halifax, Not set

The Ottawa General Hospital, Ottawa, Not set

Saskatoon Cancer Center, Saskatoon, Not set

"Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)", Sherbrooke, Not set

Princess Margaret Cancer Centre, Toronto, Not set

BC Cancer, Vancouver, Not set

Beijing Chaoyang Hospital, Beijing, Not set

Peking University First Hospital, Beijing, Not set

North China University of Science and Technology Affiliated Hospital.Hematology Department, Hebei, Not set

Henan Cancer Hospital, Henan, Not set

Shandong Qilu Hospital, Shandong, Not set

Shanghai Fourth People's Hospital, Shanghai, Not set

Shenyang City, Liaoning Province, Hematology department, Shenyang, Not set

Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Science, Tianjin, Not set

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set

Tongji Hospital, Tongji Medical College of Hust, Wuhan, Not set

The First Affiliated Hospital, Zhejiang University College of Medicine, Zhejiang, Not set

Fakultni Nemocnice Hradec Kralove, Hradec Králové, Not set

University Hospital Olomouc, Olomouc, Not set

Fakultni Nemocnice Ostrava, Ostrava, Not set

Fakultni Nemocnice Plzen, Plzen, Not set

Vseobecna Fakultni Nemocnice V Praze, Praha, Not set

Aarhus Universitetshospital, Aarhus, Not set

Rigshospitalet, Copenhagen, Not set

Odense University Hospital, Odense, Not set

Lillebaelt Hospital, Vejle, Not set

Centre Hospitalier Universitaire De Bordeaux, Bordeaux, Not set

Department of Hematology, CHU Lille, Lille, Not set

Institut Paoli Calmettes, Marseille, Not set

Centre Hospitalier Universitaire De Montpellier, Montpellier, Not set

Centre Hospitalier Universitaire De Nantes, Nantes, Not set

Hopital Saint Louis, Paris, Not set

Hôpital Saint-Antoine, Paris, Not set

Centre Hospitalier Universitaire De Poitiers, Poitiers, Not set

Centre Hospitalier Universitaire De Toulouse, Toulouse, Not set

University Medical Center Hamburg-Eppendorf, Hamburg, Not set

Universitaetsklinikum Heidelberg AöR, Heidelberg, Not set

Universitaetsklinikum Jena KöR, Jena, Not set

Universitaetsklinikum Schleswig-Holstein AöR, Lübeck, Not set

Klinikum rechts der Isar der TU Muenchen AöR, München, Not set

Klinikum Nuernberg, Nürnberg, Not set

Universitaetsklinikum Tuebingen AöR, Tübingen, Not set

University Hospital of Würzburg, Würzburg, Not set

University General Hospital Of Alexandroupoli, Alexandroupolis, Not set

Evaggelismos Hospital, Athens, Not set

Regional General Hospital Alexandra, Athens, Not set

Theageneio Cancer Hospital, Thessaloníki, Not set

Cork University Hospital, Cork, Not set

Beaumont Hospital, Dublin, Not set

St James's Hospital, Dublin, Not set

St Vincent's University Hospital, Dublin, Not set

University Hospital Galway, Galway, Not set

University Hospital Limerick, Limerick, Not set

The Barzilai Medical Center, Be'er Sheva, Not set

Health Care Campus, Haifa, Not set

Hadassah Medical Center, Jerusalem, Not set

Beilinson Hospital, Petah tikva, Not set

Chaim Sheba Medical Center, Ramat Gan, Not set

Tel-Aviv Sourasky Medical Center, Tel Aviv, Not set

Azienda Sanitaria Locale Al Di Alessandria, Alessandria, Not set

Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi, Ancona, Not set

AOU G. Baccelli, Bari, Not set

Policlinico di Bari, Bari, Not set

A.O. Papa Giovanni XXIII, Bergamo, Not set

A.O.U. di Bologna - Policlinico S. Orsola Malpighi, Bologna, Not set

A.O.Spedali Civili di Brescia, Brescia, Not set

Ospedale Oncologico 'A. Businco', Cagliari, Not set

Azienda Ospedaliera-Universitaria Di Cosenza, Cosenza, Not set

Careggi University Hospital, Firenze, Not set

IRCCS Ospedale Policlinico San Martino, Genova, Not set

IRCCS Ospedale Maggiore Policlinico, Milano, Not set

Azienda Ospedaliero Universitaria Di Modena, Modena, Not set

Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli, Napoli, Not set

UOC Oncoematologia, Ospedale Policlinico Federico II, Napoli, Not set

Azienda Ospedaliero-Universitaria Maggiore Della Carita, Novara, Not set

UOC Ematologia - Azienda Ospedale - Università Padova Ospedale Giustinianeo, Padova, Not set

Department of Hematology and Bone Marrow Transplant Centre, Azienda Ospedaliero - Universitaria di Parma, Parma, Not set

Fondazione IRCCS Policlinico San Matteo, Pavia, Not set

Azienda Sanitaria Locale Di Pescara, Pescara, Not set

Ospedale Santa Maria delle Croci, Ravenna, Not set

Azienda USL IRCCS Di Reggio Emilia, Reggio, Not set

Ospedale "Infermi" di Rimini, Rimini, Not set

Ematologia, Azienda Policlinico Umberto I, Roma, Not set

Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Not set

A.O.U. Città della Salute e della Scienza di Torino - SC Ematologia U, Torino, Not set

A.O.U. Ospedali Riuniti di Trieste, Trieste, Not set

Azienda Sanitaria Universitaria Friuli Centrale, Udine, Not set

Chonnam National University Hwasun Hospital, Gwangju, Not set

Department of Oncology, Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Seoul National University Hospital, Internal Medicine, Seoul, Not set

Severance Hospital, Seoul, Not set

St. Mary's Hospital, Seoul, Not set

Noordwest Ziekenhuisgroep Stichting, Alkmaar, Not set

Amsterdam University Medical Center, Amsterdam, Not set

Albert Schweitzer Ziekenhuis, Dordrecht, Not set

Maxima Medisch Centrum, Eindhoven, Not set

University Medical Center Groningen, Groningen, Not set

Dijklander Ziekenhuis, Hoorn, Not set

St. Antonius Ziekenhuis, Nieuwegein, Not set

Erasmus University Medical Center Rotterdam, Rotterdam, Not set

Maasstad Ziekenhuis, Rotterdam, Not set

Oslo University Hospital, Oslo, Not set

St. Olavs hospital HF, Trondheim, Not set

Department of Hematology and Transplantology University Clinical Center, Gdańsk, Not set

SPZOZ MSWiA w Poznaniu im. Prof. Ludwika Bierkowskiego, Poznań, Poznań, Not set

Uniwersytecki Szpital Kliniczny, Wrocław, Not set

CCAB Centro Clinico Academico Braga Associacao, Braga, Not set

Champalimaud Clinical Centre, Lisboa, Not set

Instituto Portugues De Oncologia De Lisboa Francisco Gentil E.P.E., Lisboa, Not set

Instituto Portugues De Oncologia Do Porto Francisco Gentil E.P.E., Porto, Not set

Sao Joao University Hospital Center, Porto, Not set

Unidade Local De Saude De Gaia/Espinho E.P.E., Porto, Not set

Unidade Local De Saude De Tras-Os-Montes E Alto Douro E.P.E., Vila Real, Not set

University Clinical Center of Serbia, Belgrade, Not set

Clinical Centre of Kragujevac, Kragujevac, Not set

Clinical Centre of Nis, Niš, Not set

Clinical Centre of Vojvodina, Novi Sad, Not set

University Hospital Basel, Basel, Not set

Inselspital, Bern, Not set

Kantonsspital St. Gallen, Saint Gallen, Not set

Ankara Liv Hospital, Ankara, Not set

Ankara University Hospital, Ankara, Not set

Florence Nightingale Hospital, Istanbul, Not set

Medipol Mega University Hospital, Istanbul, Not set

Ege University Medical faculty Hospital Internal Medicine Department Adult Hematology Unit, İzmir, Not set

Izmir Economy University, Medical Point Hospital, İzmir, Not set

Erciyes University Hospital, Kayseri, Not set

Hammersmith Hospital - Imperial College NHS Healthcare Trust, London, Not set

University College London (UCL), London, Not set

The Royal Marsden Hospital, Sutton, Not set

Conditions: Multiple Myeloma

Learn More ›

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

NCT05789082

Recruiting

The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of divarasib combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/13/2025

Locations: City of Hope National Medical Center, Duarte, California +65 locations

City of Hope National Medical Center, Duarte, California

City of Hope - Seacliff, Huntington Beach, California

City of Hope at Irvine Lennar, Irvine, California

UCSD Moores Cancer Center, La Jolla, California

Yale Cancer Center, New Haven, Connecticut

NYU Langone Hospital - Long Island, Mineola, New York

NYU Cancer Center, New York, New York

Mount SInai Medical Center, New York, New York

MD Anderson Cancer Center, Houston, Texas

Oncology & Hematology Associates of Southwest Virginia, Inc, Blacksburg, Virginia

Virginia Oncology Associates, Norfolk, Virginia

Hospital Britanico, Buenos Aires, Not set

Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires, Not set

Centro Oncologico Riojano Integral (CORI), La Rioja, Not set

Concord Repatriation General Hospital, Concord, New South Wales

Peter MacCallum Cancer Centre, Melbourne, Victoria

Alfred Health, Melbourne, Victoria

Cliniques Universitaires St-Luc, Bruxelles, Not set

Jessa Zkh (Campus Virga Jesse), Hasselt, Not set

Clinique Ste-Elisabeth, Namur, Not set

AZ Delta (Campus Rumbeke), Roeselare, Not set

Hospital de Cancer de Barretos, Barretos, São Paulo

Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, São Paulo

Ottawa Hospital Regional Cancer Centre, Ottawa, Ontario

Princess Margaret Cancer Center, Toronto, Ontario

Jewish General Hospital, Montreal, Quebec

Hunan Cancer Hospital, Changsha CITY, Not set

Harbin Medical University Cancer Hospital, Harbin, Not set

Shanghai Pulmonary Hospital, Shanghai, Not set

Rambam Medical Center, Haifa, Not set

Rabin MC, Petach Tikva, Not set

Tel Aviv Sourasky Medical Ctr, Tel Aviv, Not set

Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania

Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio

Irccs Istituto Nazionale Dei Tumori (Int), Milano, Lombardia

A.O. Universitaria S. Luigi Gonzaga, Orbassano, Piemonte

National Cancer Center Hospital East, Chiba, Not set

Kindai University Hospital, Osaka, Not set

National Cancer Center Hospital, Tokyo, Not set

The Cancer Institute Hospital of JFCR, Tokyo, Not set

Wakayama Medical University Hospital, Wakayama, Not set

Pusan National University Hospital, Busan, Not set

Seoul National University Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Korea University Guro Hospital, Seoul, Not set

NKI The Netherlands Cancer Institute, Amsterdam, Not set

UMC St Radboud, Nijmegen, Not set

Uniwersyteckie Centrum Kliniczne, Gda?sk, Not set

Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II, Kraków, Not set

Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn, Not set

ICO Badalona-H.U. Germans Trias i Pujol, Badalona, Barcelona

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set

Hospital General Universitario Gregorio Marañon, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Sahlgrenska University Hospital, Göteborg, Not set

Universitätsspital Basel, Basel, Not set

Inselspital Bern, Bern, Not set

Taichung Veterans General Hospital, Taichung, Not set

National Cheng Kung University Hospital, Tainan, Not set

National Taiwan Uni Hospital, Taipei, Not set

Chang Gung Medical Foundation - Linkou, Taoyuan, Not set

Beatson West of Scotland Cancer Centre, Glasgow, Not set

Barts & London School of Med, London, Not set

Conditions: Non-Small Cell Lung Cancer

Learn More ›

Study to Evaluate Tulisokibart for Hidradenitis Suppurativa (MK-7240-012)

NCT06956235

Recruiting

This is a phase 2b randomized, double-blind, placebo-controlled study of the safety and efficacy of tulisokibart in participants with moderate to severe hidradenitis suppurativa. The primary hypothesis is that at least 1 dose of tulisokibart is superior to placebo with respect to the proportion of participants achieving a 50% reduction in Hidradenitis Suppurativa Clinical Response (HiSCR50) at Week 16 (ie, at end of double-blind treatment).

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

08/13/2025

Locations: Cahaba Dermatology & Skin Health Center ( Site 0012), Birmingham, Alabama +20 locations

Cahaba Dermatology & Skin Health Center ( Site 0012), Birmingham, Alabama

Medical Dermatology Specialists ( Site 0027), Phoenix, Arizona

Northridge Clinical Trials ( Site 0004), Northridge, California

Integrative Skin Science and Research ( Site 0015), Sacramento, California

Skin Care Physicians of Georgia ( Site 0033), Macon, Georgia

Dawes Fretzin Clinical Research Group, LLC ( Site 0025), Indianapolis, Indiana

Revival Research Institute, LLC ( Site 0005), Troy, Michigan

DJL Clinical Research, PLLC ( Site 0021), Charlotte, North Carolina

Wright State Physicians Health Center ( Site 0041), Fairborn, Ohio

Palmetto Clinical Trial Services, LLC ( Site 0023), Anderson, South Carolina

Arlington Center for Dermatology ( Site 0045), Arlington, Texas

Texas Dermatology Research Center ( Site 0019), Dallas, Texas

Reveal Research Institute ( Site 0018), Frisco, Texas

Progressive Clinical Research ( Site 0020), San Antonio, Texas

Fremantle Dermatology ( Site 1402), Fremantle, Western Australia

York Dermatology Clinic & Research Centre ( Site 0106), Richmond Hill, Ontario

The Second Xiangya Hospital of Central South University ( Site 1505), Changsha, Hunan

Huashan Hospital of Fudan University ( Site 1506), Shanghai, Shanghai

Medical Corporation Kojinkai Sapporo Skin Clinic ( Site 1606), Sapporo, Hokkaido

University of the Ryukyus Hospital ( Site 1601), Ginowan, Okinawa

University Hospital,Kyoto Prefectural University of Medicine ( Site 1605), Kyoto, Not set

Conditions: Hidradenitis Suppurativa

Learn More ›

Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

NCT05156398

Recruiting

The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to \<18 years with episodic migraine.

Gender:

ALL

Ages:

Between 6 years and 17 years

Trial Updated:

08/13/2025

Locations: The Belinga Clinic, Fort Smith, Arkansas +91 locations

The Belinga Clinic, Fort Smith, Arkansas

Advanced Investigative Medicine, Inc., Hawthorne, California

Velocity Clinical Research San Diego, La Mesa, California

Colorado Springs Neurological Associates, Colorado Springs, Colorado

Advanced Neurosciences Research, LLC, Fort Collins, Colorado

Meridian Clinical Research, LLC, Washington, District of Columbia

Synergy Healthcare, Bradenton, Florida

Accel Research Sites Network - Edgewater Clinical Research Unit, Edgewater, Florida

Direct Helpers Research Center, Hialeah, Florida

New Med Research, Inc, Hollywood, Florida

Complete Health Research, Ormond Beach, Florida

D&H Tamarac Research Center LLC, Tamarac, Florida

Santos Research Center, CORP, Tampa, Florida

Augusta University, Augusta, Georgia

WR-Mount Vernon Clinical Research, LLC, Sandy Springs, Georgia

Meridian Clinical Research, LLC, Savannah, Georgia

Extraordinary Family Healthcare, Snellville, Georgia

Renew Health Clinical Research LLC, Snellville, Georgia

Northwest Clinical Trials, Inc., Boise, Idaho

Diamond Headache Clinic, Chicago, Illinois

Safe Haven Clinical Research, Clinton, Mississippi

University of Missouri - Investigational Pharmacy, Columbia, Missouri

Velocity Clinical Research, Inc., Grand Island, Nebraska

Papillion Research Center/CCT Research, Papillion, Nebraska

Renown Regional Medical Center, Reno, Nevada

Dent Neurosciences Research Center, Inc., Amherst, New York

Montefiore Medical Center, Bronx, New York

Carolina Institute for Clinical Research, LLC, Fayetteville, North Carolina

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Velocity Clinical Research, Cincinnati, Ohio

Lynn Health Science Institute, Oklahoma City, Oklahoma

Coastal Pediatric Research, Charleston, South Carolina

Tribe Clinical Research LLC, Greenville, South Carolina

Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota

Avera Medical Group Pediatric Specialists, Sioux Falls, South Dakota

Avera Research Institute, Sioux Falls, South Dakota

Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee

Alina Clinical Trials, LLC., Dallas, Texas

North Texas Center for Clinical Research, Frisco, Texas

DM Clinical Research - Cy Fair, Houston, Texas

SCLA Management - Drop Box, Houston, Texas

SCLA Management Office, Houston, Texas

NeuroCare Plus, Houston, Texas

Red Star Research, LLC, Lake Jackson, Texas

DCT-McAllen Primary Care Research, LLC dba Discovery Clinical Trials, McAllen, Texas

Texas Institute for Neurological Disorders, Sherman, Texas

DM Clinical Research (Administrative Office Only), Tomball, Texas

Victoria Clinical Research Group, Victoria, Texas

South Ogden Family Medicine Ogden Clinic/CCT Research, South Ogden, Utah

Meridian Clinical Research, LLC, Portsmouth, Virginia

Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia

Children's Hospital of Eastern Ontario, Ottawa, Ontario

Centre Hospitalier Intercommunal de Créteil, Créteil, Not set

Centre Hospitalier Universitaire de Montpellier, Montpellier, Not set

Hopital des Enfants, Toulouse, Not set

UOSVD Centro Epilessia ed EEG dellEta Evolutiva, Bari, BARI / Puglia

Spedali Civili di Brescia, Brescia, Brescia/lombardy

Sapienza Universita di Roma Polo Pontino - ICOT, Headache clinic, Latina, Latina/lazio

Ospedale Pediatrico Bambino Gesu, Roma, Lazio

IRCCS San Raffaele, Roma, Lazio

Istituto Neurologico "Carlo Besta" Fondazione IRCCS, Milano, Lombardia

U.O. Neuropsichiatria Infantile, IRCCS Fondazione Mondino, Pavia, Lombardia

Dipartimento Materno Infantile e Scienze UroGinecologiche - UOC Pediatria, Roma, Not set

Jinnouchi Neurosurgical Clinic, Kasuga-shi, Fukuoka

Hikita Pediatric Clinic, Kiryu-shi, Gunma

Konan Medical Center, Higashinada-ku Kobe-shi, Hyōgo

Yamaguchi Clinic, Nishinomiya-shi, Hyōgo

Mito Kyodo General Hospital, Mito-shi, Ibaraki

Tanaka Neurosurgery & Headache Clinic, Kagoshima-city, Kagoshima

Atago Hospital, Kochi-shi, Kōchi

Sendai Headache and Neurology Clinic, Taihaku-ku Sendai-shi, Miyagi

Tennouji Dai Brain Clinic, Abeno-ku Osaka-shi, Osaka

Tominaga Clinic, Naniwa-ku, Osaka

Saitama Neuropsychiatric Institute, Chuo-ku Saitama-shi, Saitama

Tokyo Headache Clinic, Shibuya-ku, Tokyo

Tokyo Medical University Hospital, Shinjuku-ku, Tokyo

LIAC Hiroshima City Hospital Organization Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Not set

MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak, Wroclaw, Dolnoslaskie

NZOZ Neuromed M. i M. Nastaj Sp. P., Lublin, Lubelskie

Wojewodzki Specjalistyczny Szpital Dzieciecy, Krakow, Malopolskie

MTZ Clinical Research Powered by Pratia, Warszawa, Mazowieckie

NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Katowice, Slaskie

Neurologia Slaska Centrum Medyczne, Katowice, Slaskie

Clinical Research Center Sp. z o.o. MEDIC-R Sp. k., Poznan, Wielkopolskie

Next Stage Sp. Z o.o., Warsaw, WOJ. Mazowieckie

Hospital Universitari Parc Tauli, Sabadell, Barcelona

Hospital Clinico Universitario de Valladolid (HCUV), Valladolid, Castilla Y LEON

Hospital Alvaro Cunqueiro, Vigo, Galicia

Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, LA Coruna

Instituto de Investigaciones del Sueno, Madrid, Not set

Virgen del Rocio Hospital, Sevilla, Not set

Hospital Universitario y Politecnico La Fe, Valencia, Not set

Conditions: Migraine

Learn More ›

Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

NCT06858839

Recruiting

The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.

Gender:

ALL

Ages:

Between 18 years and 99 years

Trial Updated:

08/13/2025

Locations: Pinnacle Research Group LLC, Anniston, Alabama +242 locations

Pinnacle Research Group LLC, Anniston, Alabama

Alliance For Multispecialty Research - Daphne, Daphne, Alabama

Alliance for Multispecialty Research Mobile, Mobile, Alabama

Avacare Foothills Research Center, Phoenix, Arizona

Ark Clinical Research- Tustin, Fountain Valley, California

Long Beach Clinical Trials Services Inc, Long Beach, California

Ark Clinical Research- Long Beach, Long Beach, California

Catalina Research Institute, Montclair, California

Artemis Institute for Clinical Research, Riverside, California

Artemis Institute for Clinical Research, San Diego, California

Apex Clinical Research, San Diego, California

Southern California Clinical Research, Santa Ana, California

Diablo Clinical Research, Walnut Creek, California

Yale School of Medicine, New Haven, Connecticut

Chase Medical Research LLC, Waterbury, Connecticut

Indago Research and Health Center, Hialeah, Florida

Jacksonville Center for Clinical Research, Jacksonville, Florida

Clinical Neuroscience Solutions - Jacksonville, Jacksonville, Florida

South Florida Wellness and Clinical Research Institute, Margate, Florida

Optimus U Corporation, Miami, Florida

Research Institute of South Florida, Miami, Florida

Renstar Medical Research, Ocala, Florida

Clinical Neuroscience Solutions - Orlando, Orlando, Florida

Combined Research Orlando Phase I IV, Orlando, Florida

Florida Institute for Clinical Research, Orlando, Florida

Encore Medical Research of Weston LLC, Weston, Florida

Center for Advanced Research and Education, Gainesville, Georgia

Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group, Union City, Georgia

East-West Medical Research, Honolulu, Hawaii

Solaris Clinical Research, Meridian, Idaho

Flourish Research - Great Lakes Clinical Trials, Chicago, Illinois

Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie, Skokie, Illinois

Evanston Premier Healthcare Research LLC, Skokie, Illinois

Alliance for Multispecialty Research Newton, Newton, Kansas

Louisville Metabolic and Atherosclerosis Research Center, Louisville, Kentucky

Velocity Clinical Research - Baton Rouge, Baton Rouge, Louisiana

Tandem Clinical Research - Marrero, Marrero, Louisiana

Headlands Research - Detroit, Southfield, Michigan

Prime Health and Wellness Sky Clinical Research Network Group, Fayette, Mississippi

Alliance for Multispecialty Research - Kansas City, Kansas City, Missouri

Palm Research Center Inc, Las Vegas, Nevada

Vector Clinical Trials, Las Vegas, Nevada

Rochester Clinical Research, Rochester, New York

Velocity Clinical Research- Binghamton, Vestal, New York

Accellacare of Hickory, Hickory, North Carolina

Carolina Research Center Inc, Shelby, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Clinical Trial Investigator Clinical Research Center, Cincinnati, Ohio

Velocity Clinical Research - Cincinnati, Cincinnati, Ohio

Alliance for Multispecialty Research - Norman, Norman, Oklahoma

Capital Area Research LLC, Newport, Pennsylvania

Velocity Clinical Research - Providence, East Greenwich, Rhode Island

Tribe Clinical Research LLC Dba Mountain View Clinical Research, Greenville, South Carolina

New Phase Research and Development, Knoxville, Tennessee

Accellacare US Inc., d/b/a Accellacare of Knoxville, Knoxville, Tennessee

Elligo Clinical Research Center, Austin, Texas

Cedar Health Research, LLC, Dallas, Texas

Epic Medical Research - Texas, DeSoto, Texas

Great Lakes Research Institute El Paso Research, El Paso, Texas

Cedar Health Research, LLC, Euless, Texas

Juno Research LLC, Houston, Texas

Biopharma Informatic, LLC, Houston, Texas

Juno Research LLC, Houston, Texas

Southern Endocrinology Associates PA, Mesquite, Texas

Great Lakes Research Institute - McAllen Research, Pharr, Texas

Clinical Trials of Texas, San Antonio, Texas

Sugar Lakes Family Practice, Sugar Land, Texas

Pantheon Clinical Research, Bountiful, Utah

Alliance for Multispecialty Research Layton Research Center, Layton, Utah

Chrysalis Clinical Research, LLC, Saint George, Utah

Washington Center for Weight Management and Research, Inc, Arlington, Virginia

Health Research of Hampton Roads, Newport News, Virginia

Selma Medical Associates, Winchester, Virginia

Allegiance Research Specialists, Milwaukee, Wisconsin

Cedic - Centro de Investigacion Clinica, Caba, Buenos Aires

Centro Medico Viamonte, Caba, Buenos Aires

Cemedic Centro de Especialidades Medicas, Caba, Buenos Aires

Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada, Caba, Buenos Aires

Consultorios Medicos Dr Besada, Caba, Buenos Aires

Fundacion Respirar, Caba, Buenos Aires

Cinme - Centro de Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires, Buenos Aires

Ciprec - Centro de Investigacion y Prevencion Cardiovascular, Ciudad Autonoma de Buenos Aires, Buenos Aires

Emeritus Research Sydney, Botany, New South Wales

Novatrials, Charlestown, New South Wales

Canopy Clinical Sutherland, Miranda, New South Wales

Royal North Shore Hospital, St Leonards, New South Wales

Canopy Clinical Wollongong, Wollongong, New South Wales

Logan Hospital, Meadowbrook, Queensland

Fusion Clinical Research, Norwood, South Australia

Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia

Canopy Clinical Altona North, Altona North, Victoria

Emeritus Research Camberwell, Camberwell, Victoria

Austin Health, Heidelberg Repatriation Hospital, Heidelberg West, Victoria

Hopital de Warquignies, Boussu, Not set

Universitair Ziekenhuis Antwerpen, Edegem, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Algemeen Ziekenhuis Groeninge - Campus Kennedylaan, Kortrijk, Not set

Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Not set

Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège, Not set

Algemeen Ziekenhuis Sint-Maarten, Mechelen, Not set

tlc Diabetes and Endocrinology, Surrey, British Columbia

Wharton Medical Clinic, Hamilton, Ontario

North York Diagnostic and Cardiac Centre, North York, Ontario

Centricity Research Oshawa Multispecialty, Oshawa, Ontario

Heart Health Institute Research Incorporated, Scarborough, Ontario

Curans Heart Center, Thunder Bay, Ontario

Centricity Research Toronto, Toronto, Ontario

Diabetes Heart Research Centre, Toronto, Ontario

Ecogene-21, Chicoutimi, Quebec

CardioVasc HR Incorporated, St Jean sur Richelieu, Quebec

Centre de Medecine Metabolique de Lanaudiere, Terrebonne, Quebec

Institut Universitaire de cardiologie et de pneumologie de Quebec, Quebec, Not set

Medicus Services sro, Brandys nad Labem, Not set

Fakultni nemocnice Brno, Brno, Not set

Endohope Havirov sro, Havirov, Not set

PreventaMed sro, Olomouc, Not set

CCR Ostrava sro, Ostrava, Not set

Fakultni nemocnice Kralovske Vinohrady, Praha 10, Not set

Ob klinika as, Praha 3, Not set

Institut klinicke a experimentalni mediciny, Praha 4, Not set

Endokrinologie Cerny Most sro, Praha 9, Not set

Vseobecna fakultni nemocnice v Praze, Praha, Not set

Endohope klinika sro, Praha, Not set

Sanos Gandrup, Gandrup, Not set

Gentofte Hospital, Hellerup, Not set

Sanos Clinic, Herlev, Not set

Steno Diabetes Center Copenhagen, Herlev, Not set

Regionshospitalet Godstrup, Herning, Not set

Hvidovre Hospital, Hvidovre, Not set

Obesity Research Unit, Helsinki, Not set

Health Step Finland, Kuopio, Not set

Oulu University Hospital, Oulu, Not set

Universitaetsklinikum Aachen, Aachen, Not set

Kardiologische Praxis Dr med Wolfgang Jungmair, Bad Homburg, Not set

Universitaets-Herzzentrum Freiburg - Bad Krozingen, Bad Krozingen, Not set

Diabetespraxis Bad Mergentheim, Bad Mergentheim, Not set

Universitaetsklinikum der Ruhr-Universitaet Bochum, Bad Oeynhausen, Not set

Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin, Not set

Velocity Clinical Research GmbH, Berlin, Not set

Diabetespraxis Dr. Hermann Braun, Berlin, Not set

Mvz am Bahnhof Spandau, Berlin, Not set

Universitaetsklinikum Dresden, Dresden, Not set

Zentrum fuer Klinische Studien Suedbrandenburg GmbH, Elsterwerda, Not set

InnoDiab Forschung, Essen, Not set

Praxis am Markt Dr. Bernd Becker, Essen, Not set

Schwerpunktpraxis fuer Diabetes, Gefaess- & Ernaehrungsmedizin, Falkensee, Not set

ClinPhenomics CVC GmbH, Frankfurt am Main, Not set

Diabeteszentrum Hamburg West, Hamburg, Not set

Endokrinologikum Hamburg, Hamburg, Not set

Diabetologische Schwerpunktpraxis Hohenmoelsen, Hohenmoelsen, Not set

Braun Ambulantes Herzzentrum Kassel, Kassel, Not set

Universitaetsklinikum Leipzig, Leipzig, Not set

AmBeNet GmbH, Leipzig, Not set

Universitaetsklinikum Schleswig-Holstein - Luebeck, Luebeck, Not set

Marienhaus Klinikum Mainz, Mainz, Not set

Kardiologische Praxis Doktor Jens Taggeselle, Markkleeberg, Not set

Centrum für Diagnostik und Gesundheit, Muenchen, Not set

Zentrum fuer Diabtes und Gefaesskrankheiten im Franziskus Carré Muenster, Muenster, Not set

Praxis Segner - Dr. Braun - Kirsch, Oberwuerzbach, Not set

Red-Institut GmbH, Oldenburg, Not set

Gemeinschaftspraxis Prof Jacob/ Dr Jacob, Villingen-Schwenningen, Not set

Zentrum fuer klinische Forschung Allgaeu Oberschwaben, Wangen IM Allgaeu, Not set

IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola, Bologna, Not set

Universita degli Studi Gabriele D Annunzio di Chieti e Pescara, Chieti, Not set

Azienda Ospedaliero Universitaria Careggi, Firenze, Not set

IRCCS Centro Cardiologico Monzino, Milano, Not set

Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milano, Not set

Ospedale Civico, Di Cristina e Benfratelli, Palermo, Not set

Azienda Ospedaliero Universitaria Pisana, Pisa, Not set

Fondazione Policlinico Tor Vergata, Roma, Not set

Medical Corporation Hitomikai Motomachi Takatsuka Naika Clinic, Yokohama-shi, Kanagawa

Doujin Memorial Foundation, Meiwa Hospital, Chiyoda-ku, Tokyo

Tokyo Asbo Clinic, Chuo-ku, Tokyo

Medical Corp Seikoukai New Medical Research System Clinic, Hachioji-shi, Tokyo

Medical Corporation AOT Shinagawa Strings Clinic, Minato-ku, Tokyo

Clinical Research Hospital Tokyo, Shinjuku-ku, Tokyo

Medical Corporation Hanabusakai Shinei Medical Healthcare Clinic, Suginami-ku, Tokyo

Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, Not set

Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Not set

The Catholic University of Korea Bucheon St Marys Hospital, Bucheon, Gyeonggi-do, Not set

Dong-A University Hospital, Busan, Not set

Kyungpook National University Hospital, Daegu, Not set

Yeungnam University Medical Center, Daegu, Not set

Daejeon Eulji Medical Center, Eulji University, DaeJeon, Not set

Konyang University Hospital, Daejeon, Not set

Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do, Not set

Gachon University Gil Medical Center, Incheon, Not set

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Not set

Seoul National University Hospital, Seoul, Not set

Kangbuk Samsung Hospital, Seoul, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

KyungHee University Gangdong Hospital, Seoul, Not set

Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Not set

The Catholic University of Korea Yeouido St Marys Hospital, Seoul, Not set

Ajou University Hospital, Suwon-si Gyeonggi-do, Not set

Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnam-do, Not set

Gabinet Leczenia Otylosci i Chorob Dietozaleznych dr hab n med Lucyna Ostrowska, Bialystok, Not set

Kresmed Spolka z Ograniczona Odpowiedzialnoscia, Bialystok, Not set

Etg Lublin Spzoo, Debica, Not set

Futuremeds Spolka z ograniczona odpowiedzialnoscia, Gdynia, Not set

Uniwersyteckie Centrum Kliniczne im Prof K Gibinskiego Slaskiego UM w Katowicach, Katowice, Not set

Salvia-Lekston i Madej Spolka Jawna, Katowice, Not set

Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna, Lodz, Not set

Ekamed Spolka z Ograniczona Odpowiedzialnoscia, Lublin, Not set

Centrum Zdrowia Metabolicznego Pawel Bogdanski, Poznan, Not set

Clinical Research Center Spzoo Medic-R Spolka Komandytowa, Poznan, Not set

Futuremeds Spolka z ograniczona odpowiedzialnoscia, Warszawa, Not set

Clinical Best Solutions Sp zoo Spolka komandytowa, Warszawa, Not set

Ponce Medical School Foundation Inc, Ponce, Not set

Puerto Rico Medical Research Inc., Ponce, Not set

Latin Clinical Trial Center, San Juan, Not set

Wellness Clinical Research Vega Baja, Vega Baja, Not set

Centro Periferico de Especialidades Bola Azul, Almeria, Andalucía

Hospital Vithas Sevilla, Castilleja de la Cuesta, Andalucía

Hospital Infanta Elena, Huelva, Andalucía

Hospital Virgen del Camino, Sanlucar de Barrameda, Andalucía

Nuevas Tecnologias en Diabetes y Endocrinologia, Sevilla, Andalucía

Hospital Quironsalud Infanta Luisa, Sevilla, Andalucía

Hospital Medico Quirurgico San Rafael, A Coruña, Galicia

Clinica Ruber SA, Pozuelo de Alarcon, Madrid

Clinica Universidad de Navarra, Pamplona, Navarra

Clinica Juaneda, Palma, Not set

Hospital Universitario Doctor Peset, Valencia, Not set

Universitaetsspital Basel, Basel, Not set

Hopitaux Universitaires de Geneve, Geneve 14, Not set

Kantonsspital Sankt Gallen, Sankt Gallen, Not set

Stoffwechselzentrum Sankt Gallen, Sankt Gallen, Not set

Universitaetsspital Zuerich, Zuerich, Not set

Ormeau Clinical Trials Ltd, Belfast, Not set

FutureMeds Birmingham, Birmingham, Not set

Layton Medical Centre, Blackpool, Not set

Waterloo Medical Centre, Blackpool, Not set

Southmead Hospital, Bristol, Not set

The Rame Group Practice, Cornwall, Not set

Staploe Medical Centre, Ely, Not set

FutureMeds Glasgow, Glasgow, Not set

Hull Royal Infirmary, Hull, Not set

NIHR Leicestershire & Northamptonshire Commercial Research Delivery Centre, Leicester, Not set

Aintree University Hospital, Liverpool, Not set

FutureMeds Newcastle, Newcastle Upon Tyne, Not set

Atlantic Medical Group, Penzance, Not set

Clifton Medical Centre, Rotherham, Not set

Ashfields Primary Care Centre, Sandbach, Not set

Conditions: Obesity

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The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

NCT05203172

Recruiting

The purpose of this clinical trial (called the FLOTILLA study) is to give continued access to the study medicines, as well as safety follow-up, for participants in prior clinical trials of encorafenib and/or binimetinib. All participants who took part in earlier encorafenib and/or binimetinib studies may participate the FLOTILLA study if they are still benefiting from the use of the study medicines. This will be determined by the study doctor. People may not participate in the FLOTILLA study if... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/12/2025

Locations: St. Joseph's Hospital and Medical Center, Phoenix, Arizona +62 locations

St. Joseph's Hospital and Medical Center, Phoenix, Arizona

Emory University Hospital Midtown, Atlanta, Georgia

Emory University Hospital, Atlanta, Georgia

Investigational Drug Service Emory University Clinic, Atlanta, Georgia

Winship Cancer Institute of Emory University, Atlanta, Georgia

Massachusetts General Hospital, Boston, Massachusetts

HealthPartners Cancer Research Center, Saint Paul, Minnesota

Regions Hospital Pharmacy, Saint Paul, Minnesota

HealthPartners Specialty Center, Saint Paul, Minnesota

Siteman Cancer Center, Saint Louis, Missouri

Barnes-Jewish Hospital, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

MSK Basking Ridge, Basking Ridge, New Jersey

Rockefeller Outpatient Pavilion (53rd Street), New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Peter MacCallum Cancer Centre, Melbourne, Victoria

Liga Norte Riograndense Contra o Câncer, Natal, RIO Grande DO Norte

ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijui, RIO Grande DO SUL

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, SÃO Paulo

BP - A Beneficencia Portuguesa de São Paulo, Sao Paulo, SÃO Paulo

Real e Benemerita Associacao Portuguesa de Beneficencia, Sao Paulo, SÃO Paulo

Princess Margaret Cancer Centre, Toronto, Ontario

Jewish General Hospital, Montreal, Quebec

Vseobecna fakultni nemocnice v Praze, Prague 2, Praha 2

Hopital Claude Huriez - CHU de Lille, Lille, Nord

Gustave Roussy, Villejuif, Val-de-marne

Universitaetsklinikum Tuebingen, Tübingen, Baden-württemberg

Otto-von-Guericke-Universitat Magdeburg, Magdeburg, Sachsen-anhalt

Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin, Not set

Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set

Rambam Health Care Campus, Haifa, Hatsafon

Instituto Tumori Giovanni Paolo II, Bari, Puglia

Istituto Nazionale Tumori Regina Elena, Rome, Roma

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set

Istituto Europeo di Oncologia IRCCS, Milano, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Not set

Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [seoul]

Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [seoul]

Samsung Medical Center, Seoul, Seoul-teukbyeolsi [seoul]

Radboudumc, Nijmegen, Gelderland

Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, Noord-holland

Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL), Amsterdam, Noord-holland

Isala, locatie Zwolle, Zwolle, Not set

Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Lisboa

Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set

N.N.Petrov Research Institute of Oncology, Saint Petersburg, Sankt-peterburg

Fed State Budgetary Inst "N.N. Blokhin Med Center of Oncology" MHRF, Moscow, Not set

N.N.Petrov Research Institute of Oncology, Saint Petersburg, Not set

Narodny onkologicky ustav, Bratislava, Bratislavský KRAJ

CHUAC-Hospital Teresa Herrera, A Coruña, A Coruña [LA Coruña]

Institut Català d'Oncologia (ICO) - Badalona, Badalona, Barcelona [barcelona]

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [barcelona]

Hospital Clinic de Barcelona, Barcelona, Catalunya [cataluña]

Hospital Clínic de Barcelona, Barcelona, Catalunya [cataluña]

Hospital Universitario Arnau de Vilanova de Lleida, Lleida, Lleida [lérida]

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad DE

Hospital Universitari Vall d'Hebron, Barcelona, Not set

Hospital Universitario HM Sanchinarro, Madrid, Not set

H.R.U Málaga - Hospital General, Málaga, Not set

Hospital Universitario Central de Asturias, Oviedo, Not set

Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital, Preston, Lancashire

Conditions: Solid Tumors

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A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

NCT04176198

Recruiting

This study is a Phase 1/2, multicenter, dose-escalation, open-label trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of nuvisertib (TP-3654) in patients with intermediate or high-risk primary or secondary MF.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/12/2025

Locations: University of Alabama, Birmingham, Alabama +77 locations

University of Alabama, Birmingham, Alabama

The University of Arizona Cancer Center, Tucson, Arizona

City of Hope, Duarte, California

University of Southern California, Los Angeles, California

Hoag Family Cancer Institute, Newport Beach, California

Blood Cancer Center, Denver, Colorado

Yale School of Medicine, New Haven, Connecticut

University of Florida Health Shands Cancer Hospital, Gainesville, Florida

University of Miami, Miami, Florida

Baptist Health - Miami Cancer Institute, Miami, Florida

Emory University, Atlanta, Georgia

University of Chicago, Chicago, Illinois

University of Maryland, Baltimore, Maryland

Massachusetts General Hospital, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

University of Minnesota, Minneapolis, Minnesota

Washington University of Medicine, Saint Louis, Missouri

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey

Montefiore Cancer Center, Bronx, New York

Roswell Park Comprehensive Cancer Center, Buffalo, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Weill Cornell Medical Center, New York, New York

Duke Cancer Institute, Durham, North Carolina

Ohio State University, Columbus, Ohio

Medical University of South Carolina, Charleston, South Carolina

Tri-Star Centennial Medical Center, Nashville, Tennessee

Vanderbilt University, Nashville, Tennessee

MD Anderson Cancer Center, Houston, Texas

Huntsman Cancer Institute, Salt Lake City, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

University of Washington - Fred Hutchinson Cancer Center, Seattle, Washington

Royal Adelaide Hospital, Adelaide, South Australia

Eastern Health Box Hill Hospital, Box Hill, Victoria

Monash University, Clayton, Victoria

Peter McCallum Center, Melbourne, Victoria

Epworth Healthcare, Richmond, Victoria

Icon Cancer Centre (Ashford Cancer Centre Research), Adelaide, Not set

University Hospitals Leuven, Leuven, Vlaams-Brabant

ZNA Cadix, Antwerp, Not set

ZNA Middelheim, Antwerp, Not set

Universitair Ziekenhuis Gent, Gent, Not set

CHU de Liege, Liege, Not set

University of Calgary, Calgary, Alberta

St. Paul's Hospital Hematology/Oncology Research, Vancouver, British Columbia

University of British Columbia, Vancouver, British Columbia

Princess Margaret Cancer Center, Toronto, Ontario

Jewish General Hospital, Montreal, Quebec

Centre Hospitalier Universitaire D'Amiens, Amiens, Not set

CHU Angers, Angers, Not set

Centre Hospitalier Lyon Sud, Lyon, Not set

Hospitalier Universitaire (CHU) de Nice - Hopital de l'Archet, Nice, Not set

Institut de cancerologie du Gard, Nimes, Not set

Hospital Saint Louis, Paris, Not set

Institut Gustave Roussy, Villejuif, Not set

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Not set

Istituto Nazionale Tumori, IRCCS Centro di Riferimento Oncologico di Aviano, Aviano, Not set

IRCCS Azienda Ospedaliero -Universitaria Di Bologna - Dipartimento Malattie Oncologiche ed Ematologiche - UO Ematologia, Bologna, Not set

ASST - Spedali Civili di Brescia, Brescia, Not set

IRCCS istituto Romagnolo per lo studio dei tumori "Dino Amadori", Meldola, Not set

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Not set

Università degli Studi di Milano-Bicocca, Milan, Not set

Azienda Ospedaliera Universitaria Citta' Della Salute E della Scienza di Torino, Torino, Not set

Aichi Medical University Hospital, Aichi, Not set

National Cancer Center Hospital East, Chiba, Not set

Kyushu University Hospital, Fukuoka, Not set

Hokkaido University Hospital, Hokkaido, Not set

University of Miyazaki Hospital, Miyazaki, Not set

Okayama University Hospital, Okayama, Not set

The University of Osaka Hospital, Osaka, Not set

Saitama Medical Center, Saitama, Not set

Tohoku University Hospital, Sendai, Not set

Shizuoka Cancer Center, Shizuoka, Not set

Juntendo University Hospital, Tokyo, Not set

Mie University Hospital, Tsu, Not set

United Lincolnshire Hospitals NHS Trust - Pilgrim Hospital, Lincoln, Not set

University College London Hospital's NHS foundation Trust, London, Not set

Conditions: Myelofibrosis

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A Study of MK-1084 Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

NCT06345729

Recruiting

This is a study evaluating the efficacy and safety of MK-1084 with pembrolizumab as first-line treatment in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) with identified Kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation and programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%. There are two primary study hypotheses: Hypothesis 1: Combination of MK-1084 and pembrolizumab is superior to placebo plus pembrolizumab with re... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/12/2025

Locations: CBCC Global Research, Inc. ( Site 0123), Bakersfield, California +184 locations

CBCC Global Research, Inc. ( Site 0123), Bakersfield, California

Beverly Hills Cancer Center ( Site 0116), Beverly Hills, California

Mount Sinai Cancer Center ( Site 0137), Miami Beach, Florida

Orchard Healthcare Research Inc. ( Site 0115), Skokie, Illinois

Truman Medical Center ( Site 0126), Kansas City, Missouri

Cox Medical Center North ( Site 0133), Springfield, Missouri

St. Vincent Frontier Cancer Center-Research ( Site 0105), Billings, Montana

Atlantic Health System Morristown Medical Center ( Site 0121), Morristown, New Jersey

New York Oncology Hematology, P.C. ( Site 0132), Albany, New York

University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0103), Cincinnati, Ohio

Kettering Health Main Campus-Kettering Health Cancer Center ( Site 0106), Kettering, Ohio

Oncology Consultants P.A. ( Site 0113), Houston, Texas

Circuit Clinical/SSM Health Dean Medical Group ( Site 0129), Madison, Wisconsin

AUSTRAL MEDICAL CENTER ( Site 0302), Caba, Buenos Aires

Centro Oncologico Korben ( Site 0304), Caba, Buenos Aires

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0300), Mar del Plata, Buenos Aires

Fundacion Estudios Clinicos ( Site 0306), Rosario, Santa Fe

Sanatorio Parque ( Site 0301), Rosario, Santa Fe

Chris O'Brien Lifehouse ( Site 3000), Camperdown, New South Wales

Frankston Hospital ( Site 3002), Frankston, Victoria

One Clinical Research ( Site 3001), Nedlands, Western Australia

Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 2401), Graz, Steiermark

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2400), Wien, Not set

Hospital Mario Penna ( Site 0436), Belo Horizonte, Minas Gerais

Hospital de Câncer de Recife ( Site 0447), Recife, Pernambuco

Oncoclínica Oncologistas Associados ( Site 0441), Terezina, Piaui

Liga Norte Riograndense Contra o Câncer ( Site 0439), Natal., Rio Grande Do Norte

Irmandade da Santa Casa de Misericórdia de Porto Alegre-Centro Multidisciplinar de Pesquisa Clínica ( Site 0435), Porto Alegre, Rio Grande Do Sul

Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 0437), Barretos., Sao Paulo

Instituto Nacional de Câncer - INCA ( Site 0446), Rio de Janeiro, Not set

Americas ( Site 0431), Rio de Janeiro, Not set

MBAL Uni Hospital-Department of Medical Oncology ( Site 1000), Panagyurishte, Pazardzhik

MHAT - Heart and Brain ( Site 1006), Pleven, Not set

CancerCare Manitoba ( Site 0210), Winnipeg, Manitoba

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0205), Hamilton, Ontario

Sunnybrook Research Institute ( Site 0206), Toronto, Ontario

St. Marys Hospital Center ( Site 0204), Montreal, Quebec

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0207), Trois-Rivières, Quebec

Clinica Universidad Catolica del Maule-Oncology ( Site 0500), Talca, Maule

Orlandi Oncologia-Oncology ( Site 0503), Santiago, Region M. De Santiago

FALP-UIDO ( Site 0501), Santiago, Region M. De Santiago

Centro de Oncología de Precisión-Oncology ( Site 0502), Santiago, Region M. De Santiago

Bradfordhill-Clinical Area ( Site 0504), Santiago, Region M. De Santiago

Anhui Provincial Cancer Hospital ( Site 3136), Hefei, Anhui

Beijing Cancer hospital ( Site 3133), Beijing, Beijing

Beijing Cancer hospital ( Site 3134), Beijing, Beijing

Beijing Peking Union Medical College Hospital-pneumology department ( Site 3102), Beijing, Beijing

Beijing Chest Hospital,Capital Medical University ( Site 3104), Beijing, Beijing

Chongqing University Cancer Hospital ( Site 3119), Chongqing, Chongqing

Army Medical Center of People's Liberation Army ( Site 3142), Chongqing, Chongqing

Fujian Cancer Hospital ( Site 3127), Fuzhou, Fujian

The First Affiliated hospital of Xiamen University ( Site 3148), Xiamen, Fujian

The First Affiliated Hospital of Guangzhou Medical University ( Site 3108), Guangzhou, Guangdong

Southern Medical University Nanfang Hospital ( Site 3128), Guangzhou, Guangdong

Sun Yat-sen University Cancer Center ( Site 3137), Guangzhou, Guangdong

Harbin Medical University Cancer Hospital ( Site 3123), Harbin, Heilongjiang

JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 3124), Jiamusi, Heilongjiang

Henan Cancer Hospital ( Site 3149), Zhengzhou, Henan

Tongji Hospital Tongji Medical,Science & Technology ( Site 3113), Wuhan, Hubei

Hubei Cancer Hospital ( Site 3126), Wuhan, Hubei

The Second Xiangya Hospital of Central South University ( Site 3130), Changsha, Hunan

Hunan Cancer Hospital ( Site 3141), Changsha, Hunan

Nanjing Gulou Hospital ( Site 3122), Nanjing, Jiangsu

Nanjing First Hospital ( Site 3154), Nanjing, Jiangsu

The First Affiliated Hospital of Soochow University ( Site 3146), Suzhou, Jiangsu

Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ) ( Site 3155), Wuxi City, Jiangsu

The Second Affiliated Hospital of Nanchang University ( Site 3139), Nanchang, Jiangxi

The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3138), Nanchang, Jiangxi

Jilin Province Tumor Hospital ( Site 3107), Changchun, Jilin

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3150), Xian, Shaanxi

Shandong Cancer Hospital ( Site 3116), Jinan, Shandong

LinYi Cancer Hospital ( Site 3111), Linyi, Shandong

Shanghai Chest Hospital ( Site 3100), Shanghai, Shanghai

Fudan University Shanghai Cancer Center ( Site 3144), Shanghai, Shanghai

Zhongshan Hospital,Fudan University ( Site 3143), Shanghai, Shanghai

Shanxi Cancer Hospital ( Site 3131), Taiyuan, Shanxi

The Second Affiliated Hospital of Air Force Medical University ( Site 3117), Xian, Shanxi

The Second Affiliated Hospital of Air Force Medical University ( Site 3152), Xian, Shanxi

West China Hospital, Sichuan University ( Site 3140), Cheng Du, Sichuan

The Third People's Hospital of Chengdu (CDTPH) ( Site 3157), Chengdu, Sichuan

Sichuan Cancer hospital. ( Site 3109), Chengdu, Sichuan

The Second People's Hospital of Neijiang ( Site 3105), Neijiang, Sichuan

Xinjiang Medical University Cancer Hospital - Urumqi ( Site 3101), Urumqi, Xinjiang

Yunnan Province Cancer Hospital ( Site 3153), Kunming, Yunnan

The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3115), Hangzhou, Zhejiang

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 3121), Hangzhou, Zhejiang

Taizhou Hospital of Zhejiang Province ( Site 3145), Linhai, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University ( Site 3151), Wenzhou, Zhejiang

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1103), Dijon, Bourgogne

Hôpital Ambroise Paré-Department of Respiratory Diseases and Thoracic Oncology ( Site 1105), Boulogne-Billancourt, Ile-de-France

Clinique Teissier Groupe ( Site 1100), Valenciennes, Nord

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1101), Clermont-Ferrand, Puy-de-Dome

Centre Hospitalier d'Avignon-Service d'Oncologie médicale et d'hématologie clinique ( Site 1104), Avignon, Vaucluse

High Technology Hospital Medcenter ( Site 1203), Batumi, Ajaria

Caucasus Medical Centre ( Site 1202), Tbilisi, Ajaria

American Hospital Network LLC ( Site 1208), Tbilisi, Not set

Todua Clinic, LLC ( Site 1204), Tbilisi, Not set

TSMU and Ingorokva High Medical Technology University Clinic LTD ( Site 1201), Tbilisi, Not set

New Hospitals ( Site 1200), Tbilisi, Not set

Cancer Research Centre. Mardaleishvili Medical Centre ( Site 1205), Tbilisi, Not set

Tbilisi Institute of Medicine ( Site 1206), Tbilisi, Not set

Marienhospital Stuttgart ( Site 1302), Stuttgart, Baden-Wurttemberg

Krankenhaus Bethanien ( Site 1303), Solingen, Nordrhein-Westfalen

UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1402), Patras, Achaia

THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1400), Athens, Attiki

University General Hospital of Larissa-Oncology Clinic ( Site 1403), Larissa, Thessalia

Agios Loukas Clinic ( Site 1404), Thessaloniki, Not set

G. Papanikolaou General Hospital-Pulmonary Clinic of Aristotle University of Thessaloniki ( Site 1405), Thessaloniki, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1607), Napoli, Campania

Ospedale Santa Maria delle Croci ( Site 1606), Ravenna, Emilia-Romagna

CRO-IRCCS-Clinical Oncology ( Site 1605), Aviano, Friuli-Venezia Giulia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1601), Roma, Lazio

Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1604), Milano, Lombardia

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1600), Milan, Lombardia

Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1609), Rome, Roma

Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno-UOC Oncologia Medica Livorno ( Site 1608), Livorno, Toscana

Istituto Oncologico Veneto IRCCS-Oncologia 2 ( Site 1603), Padova, Not set

Nagoya University Hospital ( Site 3309), Nagoya, Aichi

Fujita Health University Hospital ( Site 3310), Toyoake, Aichi

National Hospital Organization Shikoku Cancer Center ( Site 3315), Matsuyam, Ehime

National Hospital Organization Kyushu Cancer Center ( Site 3316), Fukuoka,, Fukuoka

Kurume University Hospital ( Site 3317), Kurume, Fukuoka

Gunma Prefectural Cancer Center ( Site 3302), Ota, Gunma

Kanazawa University Hospital ( Site 3308), Kanazawa, Ishikawa

St. Marianna University Hospital ( Site 3320), Kawasaki, Kanagawa

Matsusaka Municipal Hospital ( Site 3311), Matsusaka, Mie

Miyagi Cancer Center ( Site 3301), Natori, Miyagi

Sendai Kousei Hospital ( Site 3300), Sendai, Miyagi

Kansai Medical University Hospital ( Site 3312), Hirakata, Osaka

Osaka Medical and Pharmaceutical University Hospital ( Site 3313), Takatsuki, Osaka

Nippon Medical School Hospital ( Site 3306), Bunkyo, Tokyo

Toho University Omori Medical Center ( Site 3319), Ota, Tokyo

Tokyo Medical University Hospital ( Site 3307), Shinjuku, Tokyo

National Center for Global Health and Medicine ( Site 3305), Shinjuku, Tokyo

Chiba University Hospital ( Site 3322), Chiba, Not set

Hiroshima City Hiroshima Citizens Hospital ( Site 3314), Hiroshima, Not set

Saiseikai Kumamoto Hospital ( Site 3318), Kumamoto, Not set

Osaka Metropolitan University Hospital ( Site 3321), Osaka, Not set

The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 3606), Bupyeong-gu, Incheon

Chonnam National University Hwasun Hospital-Pulmonology ( Site 3604), Hwasun, Jeonranamdo

The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 3600), Suwon-si, Kyonggi-do

Pusan National University Yangsan Hospital-Lung Cancer Clinic ( Site 3603), Yangsan, Kyongsangnam-do

Chungnam national university hospital ( Site 3602), Jung-gu, Taejon-Kwangyokshi

Kyung Hee University Hospital ( Site 3605), Seoul, Not set

Korea University Guro Hospital ( Site 3601), Seoul, Not set

Arké SMO S.A. de C.V. ( Site 0602), Mexico, Distrito Federal

Oaxaca Site Management Organization S.C. ( Site 0603), Oaxaca, Not set

Ziekenhuis St. Jansdal-Poli Longziekten ( Site 1701), Harderwijk, Gelderland

Isala, locatie Zwolle-Poli Longziekten ( Site 1700), Zwolle, Overijssel

Universitair Medisch Centrum Utrecht ( Site 1704), Utrecht, Not set

Auckland City Hospital ( Site 3400), Auckland, Not set

Lung Center of the Philippines-Pulmonary, Critical Care and Sleep Medicine ( Site 3503), Quezon City, National Capital Region

Veterans Memorial Medical Center-Section of Oncology ( Site 3505), Quezon City, National Capital Region

Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1801), Gorlice, Malopolskie

Pratia MCM Krakow ( Site 1808), Krakow, Malopolskie

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1800), Warszawa, Mazowieckie

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1804), Przemysl, Podkarpackie

Centrul de Oncologie Sfantul Nectarie-Medical ( Site 1994), Craiova, Dolj

Cabinet Medical Oncomed ( Site 1998), Timișoara, Timis

SC ONCO CARD SRL ( Site 1995), Brasov, Not set

Institutul Oncologic Cluj-Oncologie Medicala ( Site 1999), Cluj, Not set

Sigmedical Services SRL ( Site 1997), Suceava, Not set

Hospital Insular de Gran Canaria-Oncology ( Site 2019), Las Palmas de Gran Canaria, Las Palmas

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-ONCOLOGY ( Site 2012), Madrid, Madrid, Comunidad De

H.R.U Málaga - Hospital General-Oncology ( Site 2014), Málaga, Malaga

Hospital Universitari Vall d Hebron ( Site 2010), Barcelona, Not set

Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 2017), Madrid, Not set

Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2015), Sevilla, Not set

Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2107), Adana, Not set

SBU GULHANE EGITIM VE ARASTIRMA HASTANESI Onkoloji ( Site 2104), Ankara, Not set

Hacettepe Universite Hastaneleri-oncology hospital ( Site 2101), Ankara, Not set

Memorial Ankara Hastanesi-Medical Oncology ( Site 2106), Ankara, Not set

Medipol Mega Universite Hastanesi-oncology ( Site 2105), Istanbul, Not set

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2103), Istanbul, Not set

COMMUNAL NONPROFIT ENTERPRISE "CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 2209), Cherkasy, Cherkaska Oblast

Regional Municipal Non-profit Enterprise "Bukovinian Clinica-structural unit of the clinical trials ( Site 2210), Chernivtsi, Chernivetska Oblast

Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 2215), Kryvyi Rih, Dnipropetrovska Oblast

Communal Non-Commercial Enterprise "Prykarpatski Clinical On-Surgery department #2 ( Site 2202), Ivano-Frankivsk, Ivano-Frankivska Oblast

Kirovohrad Regional Oncology Center-Chemotherapy department ( Site 2204), Kropyvnytskyi, Kirovohradska Oblast

Medical Center "MedOffice Group" ( Site 2219), Kiev, Kyivska Oblast

Municipal non-profit enterprise "Lviv Territorial Medical Union "Multidisciplinary Clinical Hospital ( Site 2217), Lviv, Lvivska Oblast

Rivne Regional Clinical Hospital ( Site 2205), Rivne, Rivnenska Oblast

ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2920), Rivne, Rivnenska Oblast

Communal Noncommercial Enterprise "Podillia Regional Oncolog-Cardiothoracic department ( Site 2211), Vinnytsia, Vinnytska Oblast

ME Volyn Regional Clinical Hospital of the Volyn Regional Council ( Site 2216), Lutsk, Volynska Oblast

Conditions: Non-small Cell Lung Cancer

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A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

NCT04462770

Recruiting

This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole hydrochloride (EPX-100) as adjunctive therapy in children and adult participants with Dravet syndrome (DS).

Gender:

ALL

Ages:

2 years and above

Trial Updated:

08/12/2025

Locations: Children's Hospital of Los Angeles, Los Angeles, California +45 locations

Children's Hospital of Los Angeles, Los Angeles, California

University of California Irvine, Orange, California

UCSF Medical Center, San Francisco, California

Yale University School of Medicine, New Haven, Connecticut

The Nemours Foundation, Wilmington, Delaware

Rare Disease Research FL, Kissimmee, Florida

Pediatric Neurology and Epilepsy Specialists, Winter Park, Florida

Clinical Integrative Research Center of Atlanta (CIRCA), Atlanta, Georgia

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

Norton Children's Research Institute, Louisville, Kentucky

University of Michigan- Mott Children's Hospital, Ann Arbor, Michigan

Children's Nebraska, Omaha, Nebraska

Northeast Regional Epilepsy Group, Hackensack, New Jersey

Neurology Center for Epilepsy and Seizures, Marlboro, New Jersey

Weill Cornell Medical Center, New York, New York

Northwell Health - Lenox Hill Hospital, New York, New York

Duke University Health System, Durham, North Carolina

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Cleveland Clinic, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Le Bonheur Children's Hospital, Memphis, Tennessee

Child Neurology Consultants of Austin, Austin, Texas

UT Southwestern/Children's Health, Dallas, Texas

University of Utah, Salt Lake City, Utah

Seattle Children's Hospital, Seattle, Washington

UBC Children's Hospital Research Institute, Vancouver, British Columbia

Children's Hospital of Eastern Ontario Research Institute Inc., Ottawa, Ontario

The Hospital for Sick Children, Toronto, Ontario

Toronto Western Hospital, University Health Network, Toronto, Ontario

Tbilisi State Medical University, Givi Zhvania Academic, Clinic of Pediatry, Tbilisi, Not set

Medi Club Georgia LLC, Tbilisi, Not set

Institute of Neurology and Neuropsychology LTD, Tbilisi, Not set

Semmelweis University, Budapest, Not set

University of Debrecen, Debrecen, Not set

University Clinical Center in Gdansk, Division of Developmental Neurology, Gdańsk, Not set

Medical Centre Plejady, Kraków, Not set

Institute of Mother and Child, Warsaw, Not set

"Prof. Dr. Al. Obregia" Psychiatry Clinical Hospital, Bucharest, Not set

Hospital Infantil Universitario Niño Jesús, Madrid, Madrid provincia

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Cardiff and Vale University Health Board, Cardiff, Not set

Alder Hey Children's NHS Foundation Trust, Liverpool, Not set

Great Ormond Street Hospital For Children, London, Not set

Sheffield Children's Hospital, Sheffield, Not set

Conditions: Dravet Syndrome

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Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis (OPERA-T Study)

NCT05238116

Recruiting

To assess the safety and efficacy of nebulized PC945 in combination with systemic antifungal therapy for the treatment of refractory IPA

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/12/2025

Locations: Clinical Research Site 029, Duarte, California +101 locations

Clinical Research Site 029, Duarte, California

Clinical Research Site 009, La Jolla, California

Clinical Research Site 122, Los Angeles, California

Clinical R Site 024, Los Angeles, California

Clinical Research Site 119, Sacramento, California

Clinical Research Site 031, Jacksonville, Florida

Clinical Research Site 022, Indianapolis, Indiana

Clinical Research Site 023, Lexington, Kentucky

Clinical Research Site 121, Baltimore, Maryland

Clinical Research Site 025, Boston, Massachusetts

Clinical Research Site 111, Ann Arbor, Michigan

Clinical Research Site 095, Minneapolis, Minnesota

Clinical Research Site 010, Saint Louis, Missouri

Clinical Research Site 018, Bronx, New York

Clinical Research Site 002, Philadelphia, Pennsylvania

Clinical Research Site 001, Pittsburgh, Pennsylvania

Clinical Research Site 030, Nashville, Tennessee

Clinical Research Site 003, Houston, Texas

Clinical Research Site 028, Houston, Texas

Clinical Research Site 118, Houston, Texas

Clinical Research Site 026, Seattle, Washington

Clinical Research Site 032, Madison, Wisconsin

Clinical Research Site 034, Buenos Aires, Not set

Clinical Research Site 033, Buenos Aires, Not set

Clinical Research Site 035, Buenos Aires, Not set

Clinical Research Site 108, Mendoza, Not set

Clinical Research Site 109, Santa Fe, Not set

Clinical Research Site 106, Melbourne, Parkville

Clinical Research Site 107, Melbourne, Victoria

Clinical Research Site 037, Graz, Not set

Clinical Research Site 036, Vienna, Not set

Clinical Research Site 098, Brussels, Not set

Clinical Research Site 038, Brussels, Not set

Clinical Research Site 039, Leuven, Not set

Clinical Research Site 044, Paraná, Curitiba

Clinical Research Site 040, Paranã, Curitiba

Clinical Research Site 042, São Paulo, Santos

Clinical Research Site 047, Rio Grande, Not set

Clinical Research Site 046, Rio Grande, Not set

Clinical Research Site 045, Rio Grande, Not set

Clinical Research Site 043, Santa Catarina, Not set

Clinical Research Site 041, São Paulo, Not set

Clinical Research Site 008, Toronto, Ontario

Clinical Research Site 110, Toronto, Ontario

Clinical Research Site 096, Hamilton, Not set

Clinical Research Site 049, Santiago, Not set

Clinical Research Site 048, Valparaíso, Not set

Clinical Research Site 051, Medellín, Not set

Clinical Research Site 050, Montería, Not set

Clinical Research Site 123, Valle, Not set

Clinical Research Site 060, Bordeaux, Not set

Clinical Research Site 097, Paris, Not set

Clinical Research Site 059, Strasbourg, Not set

Clinical Research Site 071, Würzburg, Bavaria

Clinical Research Site 069, Frankfurt, Hesse

Clinical Research Site 070, Cologne, Not set

Clinical Research Site 073, Exochí, Thessalonk

Clinical Research Site 072, Athens, Not set

Clinical Research Site104, Karna, Karnataka

Clinical Research Site 099, Pune, Maharashtra

Clinical Research Site 103, Hyderabad, Not set

Clinical Research Site 100, Hyderabad, Not set

Clinical Research Site 101, New Delhi, Not set

Clinical Research Site 102, Pune, Not set

Clinical Research Site 076, Haifa, Not set

Clinical Research Site 075, Ramat Gan, Not set

Clinical Research Site 074, Safed, Not set

Clinical Research Site 081, Brescia, Not set

Clinical Research Site 080, Milan, Not set

Clinical Research Site 077, Monza, Not set

Clinical Research Site 079, Naples, Not set

Clinical Research Site 078, Rome, Not set

Clinical Research Site 082, Siena, Not set

Clinical Research Site 086, Daejeon, Not set

Clinical Research Site 083, Gyeonggi do, Not set

Clinical Research Site 084, Incheon, Not set

Clinical Research Site 089, Seoul, Not set

Clinical Research Site 085, Seoul, Not set

Clinical Research Site 088, Seoul, Not set

Clinical Research Site 087, Seoul, Not set

Clinical Research Site 054, Barcelona, Not set

Clinical Research Site 057, Barcelona, Not set

Clinical Research Site 052, Córdoba, Not set

Clinical Research Site 053, Granada, Not set

Clinical Research Site 058, Madrid, Not set

Clinical Research Site 056, Santander, Not set

Clinical Research Site 055, Valencia, Not set

Clinical Research Site 094, Taipei, New Tapai City

Clinical Research Site 090, Tapei City, Tapai

Clinical Research Site 092, Kaohsiung, Not set

Clinical Research Site 091, New Taipei City, Not set

Clinical Research Site 093, Tainan, Not set

Clinical Research Site 113, Bangkok, Not set

Clinical Research Site 112, Bangkok, Not set

Clinical Research Site 114, Khon Kaen, Not set

Clinical Research Site 115, Pathum Thani, Not set

Clinical Research Site 065, Cambridge, Not set

Clinical Research Site 066, Harefield, Not set

Clinical Research Site 063, London, Not set

Clinical Research Site 062, London, Not set

Clinical Research Site 064, London, Not set

Clinical Research Site 067, Manchester, Not set

Conditions: Refractory IPA

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