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All Clinical Trials in Canada
A listing of 3893 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
3649 - 3660 of 3893
The Effect of Intra-operative Ketorolac on Hematoma Rates in Breast Reduction Surgery
Recruiting
It has been a longstanding teaching in plastic surgery that intra-operative ketorolac use for postoperative pain control increases hematoma and bleeding in breast reduction surgery. However, there is no literature that supports this teaching. Ketorolac is used routinely in free flap reconstruction including breast reconstruction as well as many other surgeries including hand surgery without increased risks of hematoma or bleeding. Ketorolac has been shown to give good postoperative pain control.... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: St. Paul's Hospital, Saskatoon, Saskatchewan
Conditions: Hematoma Postoperative
Pilot Study for a Machine Learning Test for Migraine
Recruiting
This study is a single center, random participant selection, data analyst is blinded to patient identifiers, controlled clinical trial.
The proposed study is intended to establish safety and efficacy of quantifiable electrical biomarkers for migraine that can be used to confirm a diagnosis in people that have already been screened as positive for migraine using the gold standard participative criteria set out in the International Classification of Headache disorders-3 (ICHD-3) criteria.
It is... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/27/2023
Locations: Headache Sciences Incorporated Laboratory, Toronto, Ontario
Conditions: Migraine, Chronic Migraine, Tension-Type Headache
Determinants of Tooth Movement in Oral Appliance Treatment of OSA.
Recruiting
Obstructive sleep apnea (OSA) is a sleep related breathing disorder, affecting approximately 10% of adults. Mandibular advancement oral appliances (OAM) are an effective treatment for OSA, however, long term use has shown to lead to changes in teeth positioning and jaw alignment (bite changes), which has resulted in some patients stopping treatment.
It is becoming common clinical practice for doctors to prescribe the use of repositioning splints to help reduce the bite changes associated with u... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
09/26/2023
Locations: University of British Columbia, Vancouver, British Columbia
Conditions: Obstructive Sleep Apnea
WithHolding Enteral Feeds Around Blood Transfusion (International)
Recruiting
The WHEAT International trial is a comparative effectiveness trial exploring whether withholding enteral feeds around the time of blood transfusion in very premature infants (\<30 weeks) will reduce the occurrence of Necrotizing Enterocolitis (NEC). Currently both continued feeding and withholding feeding are approved care practices. The current study will randomize infants from Neonatal Intensive Care Units (NICUs) across Canada and the United Kingdom (UK) into one of the two care approaches (w... Read More
Gender:
ALL
Ages:
30 weeks and below
Trial Updated:
09/26/2023
Locations: IWK Health, Halifax, Nova Scotia
Conditions: Necrotizing Enterocolitis
5-HT3 Receptor Antagonist and Respiratory Drive in Patients With ARDS
Recruiting
This is a pilot study aimed at acquiring primary physiological data, describing and estimating the effects of a 5-HT3 receptor antagonist (ondansetron) on respiratory drive in patients with acute respiratory distress syndrome (ARDS). The results of this study will determine the interest and feasibility of assessing the clinical applications of ondansetron in reducing patient self-inflicted lung injury (P-SILI) in ARDS, in subsequent studies.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/26/2023
Locations: Hôpital Sacré-Coeur de Montréal, Montréal, Quebec
Conditions: Acute Respiratory Distress Syndrome
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Recruiting
The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpose to improve patients' survival, local, and regional tumor control and quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania +17 locations
Conditions: Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer, Brain Tumor, Brain Cancer, Gynecologic Tumor, Prostate Tumor, Prostate Neoplasm, Breast Tumor, Radiation Toxicity, Quality of Life, Rectal Cancer, Rectal Tumor, Rectal Neoplasms, Lung Cancer, Lung Tumor, Lung Neoplasm, Esophageal Cancer, Esophagus Cancer, Esophageal Tumor, Esophageal Neoplasm, Esophagus Tumor, Esophagus Neoplasm, Pancreatic Cancer, Pancreatic Tumor, Pancreatic Neoplasms, Head and Neck Cancer, Head and Neck Neoplasms, Head and Neck Tumor, Tumor, Neoplasms, Bladder Cancer, Bladder Neoplasm, Liver Cancer, Liver Neoplasms, Liver Metastases, Oligometastases
Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome
Recruiting
Most patients suffering from the irritable bowel syndrome (IBS) report that ingestion of certain foods is a major trigger of symptoms, but the reason is unclear. Previous studies have shown that foods containing poorly absorbed carbohydrates (FODMAPs) are fermented by the bacteria in our bowels and these cause symptoms in some but not all patients. Gut bacteria are capable of producing various products, such as neuroimmune mediator histamine, that may be related to IBS symptoms. Our recent data... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/25/2023
Locations: McMaster University Medical Centre, Hamilton, Ontario +1 locations
Conditions: Irritable Bowel Syndrome
E-field Guided iTBS for Treatment Resistant Depression
Recruiting
The purpose of this study is to establish how personalization of repetitive transcranial magnetic stimulation (rTMS) can change markers of brain activity and improve treatment response. To do this, all participants will receive the same active form of treatments, but some of the participants in this study will receive intermittent theta burst stimulation (iTBS) rTMS treatment with standard forms of targeting and intensity, and others will receive iTBS rTMS treatment using personalized magnetic r... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/25/2023
Locations: Poul Hansen Family Centre for Depression, Toronto Western Hospital, Toronto, Ontario +1 locations
Conditions: Major Depressive Disorder
Differential EFfects of Dual antIplatelet and Dual aNtithrombotic thErapy on Hemostasis in Chronic Coronary Syndrome Patients
Recruiting
The investigators will be comparing the effects of two different drug treatment strategies, in patients with history of a heart attack, on different markers of bleeding and clotting risk. Both treatment strategies are already approved for the indication of improving outcomes in high-risk patients with history of heart attack.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
09/21/2023
Locations: Nova Scotia Health, Halifax, Nova Scotia
Conditions: Thrombosis, Myocardial Infarction
A Trial Evaluating Toxicity of SBRT and LDRB in Localized Prostate Cancer.
Recruiting
The goal of this clinical trial is to compare SBRT (Stereotactic Body RadioTherapy) to LDRB (Low-Dose Rate Brachytherapy with Iodine-125 seed implant) in patients with low and favourable intermediate-risk prostate cancer. The two main questions it aims to answer are :
1. Does SBRT (Stereotactic Body RadioTherapy) for low and intermediate risk prostate cancer patients will result in less genito-urinary (GU) and gastro-intestinal (GI) toxicities than LDRB (Low-Dose Rate Brachytherapy)?
2. Does pr... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/21/2023
Locations: Centre Intégré de Cancérologie, CHU de Québec-Université Laval, Québec, Not set
Conditions: Prostate Cancer
Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial)
Recruiting
It is hypothesized that a strategy using prophylactic oral and intravenous Tranexamic Acid (TXA) with therapeutic platelet transfusions (if required) is safe and more effective than prophylactic platelet transfusions in patients undergoing an autologous hematopoietic stem cell transplantation (ASCT).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2023
Locations: Tom Baker Cancer Centre, Calgary, Alberta +10 locations
Conditions: Hematologic Neoplasms
Impact in Older Adults of Reducing Anticholinergic and Sedative Rx Burden on Physical Function Measured by Wearables
Recruiting
Medications with sedative or anticholinergic effects such as antidepressants, benzodiazepines, or opioids have been associated with impaired cognitive and physical function. They are referred to as potentially inappropriate medications or medications that are best avoided by older adults. The accumulated evidence has now shifted the clinical and research focus to evaluating the who, what, and how of the best way to deprescribe (i.e., dose reduction or cessation of these medications). The Drug Bu... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/15/2023
Locations: CIUSSS de l'Estrie-CHUS, Sherbrooke, Quebec
Conditions: Deprescribing Anticholinergic and Sedative Medications, Physical Function
3649 - 3660 of 3893