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All Clinical Trials in Canada
A listing of 3894 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
3877 - 3888 of 3894
Canadian Network for Autoimmune Liver Disease
Recruiting
CaNAL is a longitudinal observational cohort study of patients diagnosed with Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), or overlap syndrome. This study creates a nationwide registry and network focusing on high quality long-term follow-up of individual patient data from major Canadian centers.
Primary Biliary Cholangitis (PBC) and Autoimmune Hepatitis (AIH) are rare and slowly progressive liver diseases associated with development of cirrhosis, liver cancer (HCC) and liver... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2021
Locations: Foothills Medical Centre, Calgary, Alberta +14 locations
Transfer of Sinonasal Microbiota to Treat Refractory Chronic Rhinosinusitis
Recruiting
Sinonasal microbiota transplant (SNMT) is the replacement of a patient's existing dysbiotic sinonasal microbiota with microbiota from a healthy donor, characterized by high levels of beneficial bacteria that can outcompete the existing pathogens and restore the microbial balance in the sinuses. We would like to investigate whether SNMT, using previously screened mucus from a donor, will change the microbiota of chronic rhinosinusitis (CRS) patients, thereby preventing the recurrence of sinus inf... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
06/03/2021
Locations: E.N.T. Clinic, St. Paul's Hospital, Vancouver, British Columbia
Conditions: Chronic Rhinosinusitis
Anatomic Stenosis Severity as a Prognostic Marker in Patients With Low-Flow Low-Gradient Aortic Stenosis Undergoing TAVI
Recruiting
The ATLAS TAVI Registry is a retrospective, investigator-initiated, multicenter registry including patients, who underwent Transcatheter Aortic Valve Implantation (TAVI) for classical or paradoxical low-flow, low-gradient aortic stenosis (LFLG AS) with available non-contrast MSCT data on aortic valve calcification (AVC). The main objective of this study is the assessment of outcome after TAVI according to AVC density severity in patients with LFLG AS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2021
Locations: Montreal Heart Institute, Montréal, Not set +10 locations
Conditions: Low-Flow, Low-Gradient Aortic Stenosis
Canadian SCAD Study
Recruiting
Natural history multicenter, prospective, observational registry with 10-year follow-up
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/25/2021
Locations: Vancouver General Hospital, Vancouver, British Columbia
Conditions: Spontaneous Coronary Artery Dissection, SCAD, Fibromuscular Dysplasia
Molecular Analysis of Diabetic Kidney Disease Biopsies
Recruiting
Despite decades of research, the pathogenesis of human diabetic kidney disease remains largely unclear. Our goal is to use archived human kidney biopsy tissue from patients with and with diabetic nephropathy to identify new molecules that drive and/or protect against disease progression. We will use RNA sequencing to identify transcriptomic changes that associate with histologic and functional outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/27/2021
Locations: University of British Columbia, Vancouver, British Columbia +3 locations
Conditions: Diabetic Nephropathies, Kidney Disease, Chronic
Brain Activity and Oxygenation Inflammatory Bowel Disease (IBD) Patients
Recruiting
Symptoms such as fatigue, sleep disturbances, anxiety and depression are common in patients with IBD, but the cause is unknown. Understanding how these behaviors occur in IBD and their role in symptoms may help improve management of IBD. How IBD leads to changes in brain function remains unclear. Inflammation and dysfunction of blood flow may occur in patients with IBD, which may be linked to these symptoms. Patients with IBD also have an alteration or imbalance of gut bacteria which may play a... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/26/2021
Locations: University of Calgary, Calgary, Alberta
Conditions: IBD, Maladaptive Behavior Associated With Physical Illness
Long-Term Outcomes of Hip Interventions for Children With Cerebral Palsy
Recruiting
Children with severe cerebral palsy (CP) are at high risk for progressive hip displacement, associated with pain and contractures interfering with many aspects of care, comfort and quality of life. These children undergo many types of interventions, the optimal timing and effectiveness of which, remain unclear. In 2014, CIHR funded the CP Hip Outcomes Project (CHOP), an international multi-centre prospective longitudinal cohort study of children with severe (non-ambulant) CP with evidence of hip... Read More
Gender:
ALL
Ages:
Between 2 years and 19 years
Trial Updated:
03/08/2021
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Cerebral Palsy
Personalized Oncogenomics (POG) Program of British Columbia
Recruiting
The genomic heterogeneity of cancers implies that to effectively use targeted therapies the investigators will need to assess each individual cancer and match it to a biologically relevant targeted therapy. The investigators will use full genome sequencing to try to identify cancer "drivers" and corresponding drugs that may inhibit these pathways.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/26/2021
Locations: BC Cancer Agency, Vancouver, British Columbia
Conditions: Metastatic Cancers, Advanced Cancers, Cancers That Cannot be Treated With Curative Intent
Women's Advanced Risk-assessment in Manitoba
Recruiting
The main objective of this study is to test the ability of novel cardiovascular disease (CVD) prognostic tools to identify women at risk for future CVD. We plan to establish a cardiovascular health screening program at the St. Boniface Hospital and to test the efficacy of these tests for predicting adverse cardiovascular outcomes amongst a cohort of 1000 Manitoban women aged 55 years and older in the 5-year period after screening.
A second purpose of this project is to identify novel CVD biomar... Read More
Gender:
FEMALE
Ages:
55 years and above
Trial Updated:
01/25/2021
Locations: St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba
Conditions: Cardiovascular Disease (CVD), Cardiovascular Risk Factor, Vascular Stiffness
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Tucson, Arizona +79 locations
Conditions: Ulcerative Colitis
MAVIPAN: My Life and the COVID-19 Pandemic
Recruiting
The health crisis imposed by COVID-19 is forcing major worldwide social reorganization that will have profound consequences on our society. Currently, one-third of the world's population (\~3 billion individuals) is living under some kind of isolation or quarantine measures, causing an unprecedented and rapidly evolving psychosocial crisis.
The psychosocial consequences of this health crisis will persist long after restriction measures are lifted and the pandemic is over. This impact will be si... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
10/02/2020
Locations: VITAM-Research Center in Sustainable Health, Québec, Not set
Conditions: Psychosocial Impacts of the COVID-19 Pandemic
Spinal Cord Injury Registry - North American Clinical Trials Network
Recruiting
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/22/2020
Locations: University of Miami, Miami, Florida +13 locations
Conditions: Spinal Cord Injury
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