STABLE (Strength Training and Balance Leg Exercise) Study
NCT04518098
Recruiting
Falls are a major health concern amongst older adults with cancer, and are often related to decreased physical strength due to effects of cancer and its treatments. Ample evidence demonstrates the benefits of exercise programs incorporating strength and balance training on lower body strength, balance, and fall prevention older adults. However, gaps in research exist within the geriatric oncology context. The purpose of this study is to determine the feasibility and efficacy of a 3-month, remote... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
05/08/2023
Locations: Cross Cancer Institute, Edmonton, Saskatchewan
Conditions: Neoplasms
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Comparing Local Anesthesia With and Without iPACK Block
NCT04635176
Recruiting
Total knee arthroplasty is an effective surgical intervention for patients with chronic osteoarthritis commonly performed worldwide. Postoperative pain management has been a key focus in patient care for this procedure. Poorly controlled pain following total knee arthroplasty is associated with decreased ambulation, increased length of hospital stay, increased complications (particularly related to significant opioid use), and overall suboptimal patient recovery. Appropriate postoperative pain m... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/08/2023
Locations: University of Calgary/AB Hip and Knee Clinic, Calgary, Alberta
Conditions: Osteo Arthritis Knee, Analgesia, Pain, Postoperative
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Using Clinical Prediction Models to Improve Treatment for Patients With Chronic Obstructive Pulmonary Disease (COPD)
NCT05309356
Recruiting
Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease of the lungs that affects more than 2.5 million Canadians. Patients with COPD experience episodes of lung attacks (or exacerbations). During these attacks, patients experience an intense increase in symptoms, such as breathlessness and cough. It is challenging to decide which patients should be put on treatments that would reduce the risk of such lung attacks. The digitization of health records in many clinics and hospitals means... Read More
Gender:
ALL
Ages:
35 years and above
Trial Updated:
05/08/2023
Locations: The Lung Centre, Vancouver General Hospital, Vancouver, British Columbia +1 locations
Conditions: Chronic Obstructive Pulmonary Disease
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Subgenual Cingulate Deep Brain STIMulation for Apathetic Behavioral Variant FRONtotemporal Dementia
NCT05699330
Recruiting
Frontotemporal dementia (FTD), the most common dementia in individuals younger than 60 years of age, has no disease-modifying treatment. Neuroimaging studies have revealed salience and default mode network dysfunction, frontotemporal atrophy and hypometabolism as pathophysiological hallmarks of behavioral variant FTD (bvFTD). A key brain structure affected by bvFTD is the subgenual cingulate (SGC), which serves as a hub for multi-axonal projections to and from the ventromedial prefrontal, dorsal... Read More
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
05/08/2023
Locations: Toronto Western Hospital, Toronto, Ontario
Conditions: Deep Brain Stimulation, Frontotemporal Dementia
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Syphilis and HIV Point of Care Testing (POCT) in Saskatchewan
NCT05863117
Recruiting
The goal of this clinical trial is to learn about Syphilis and HIV point of care testing among inner city, remote, rural and hard to reach populations in Saskatchewan. The main question\[s\] it aims to answer are: 1. To evaluate the field diagnostic test performance (e.g. sensitivity, specificity, predictive values) of finger prick whole blood point of care testing (POCT) when compared to standard serum based testing for syphilis POCT, HIV POCT and dual syphilis and HIV POCT. 2. To evaluate the... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
05/08/2023
Locations: Queen City Wellness Pharmacy, Regina, Saskatchewan +1 locations
Conditions: Syphilis, HIV Infections
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Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions
NCT05358340
Recruiting
The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2023
Locations: University Health Network, Toronto, Ontario
Conditions: Brain Tumor, Brain Metastases
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Honey to Improve Sleep Quality
NCT04207281
Recruiting
Inadequate sleep quality and duration affects quality of life, and can cause adverse health outcomes, for many Canadians. Existing sleep therapies have limitations, such as inability to adhere to a cognitive behaviour modification or the risk of dependence on pharmaceutical therapies. Raw honey has a long history of anecdotal reports supporting its use to improve sleep quality. In an effort to develop an evidence base for honey as a sleep aid, we completed a preliminary proof-of-principle study... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/03/2023
Locations: University of Saskatchewan, Saskatoon, Saskatchewan
Conditions: Poor Quality Sleep
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Does the Newborn Infant Parasympathetic Evaluation (NIPE) Index Predict Postsurgical Pain in Children
NCT04909060
Recruiting
An investigation to find out if Newborn Infant Parasympathetic Evaluation (NIPE) index predicts postsurgical pain in children, since NIPE is thought to may be of guide to the appropriate therapy in a timely and objective manner, thereby improving patient safety, parental satisfaction, and reducing healthcare costs. We think that, validating the utility of NIPE in children under 3 years of age will allow the implementation of a novel pain assessment tool to our current practice of anesthetic care... Read More
Gender:
ALL
Ages:
Between 3 years and 7 years
Trial Updated:
05/01/2023
Locations: Montreal Children's Hospital, Montréal, Quebec
Conditions: Post Operative Pain
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Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
NCT03945162
Recruiting
This is a phase II, open-label, single-arm, multi-center Study conducted in Canada and the United States. Patients with NMIBC CIS (with or without resected papillary disease (Ta, T1)) that are considered Bacillus Calmette-Guerin ("BCG")-Unresponsive or who are intolerant to BCG therapy. BCG-Unresponsive is at least one of the following: At least five of six doses of an initial induction course plus at least two of three doses of maintenance therapy; or, at least five of six doses of an initial i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/27/2023
Locations: Site 02-012 - University of Chicago, Chicago, Illinois +11 locations
Conditions: Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: The Kirklin Clinic of UAB Hospital, Birmingham, Alabama +190 locations
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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Dietary Counseling or Potassium Supplement to Increase Potassium Intake in Patients With High Blood Pressure
NCT03809884
Recruiting
High blood pressure is the leading cause of cardiovascular disease worldwide. Many medicines are available to lower blood pressures successfully, as well as many non-medical options, such as dietary changes. Some effective dietary changes include decreasing sodium and increasing potassium in the diet. A lot of focus has been on sodium intake yet; potassium intake in the diet remains low amongst adult Canadians. Excellent data exist in the published research reporting that increasing potassium in... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2023
Locations: Ottawa Hospital Research Institute, Ottawa, Ontario
Conditions: Hypertension
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Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
NCT05129748
Recruiting
One common side effect of cisplatin chemotherapy is ototoxicity. The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss. Specifically, sodium thiosulfate has been found to protect the cells in the inner ear, and may therefore prevent hearing loss. Mannitol can help sodium thiosulfate enter the inner ear, and ponteially increase the effectiveness of sodium thiosulfate. This study aims to assess the efficacy of sodium thiosulfate and mannitol to reduce the hea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2023
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Ototoxic Hearing Loss
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