Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Fountain Valley, California +277 locations
Conditions: Chronic Lymphocytic Leukemia
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A Safety Study of AZD4041 in Healthy Volunteers
NCT05209334
Recruiting
This is a Phase 1, single-centre, randomized, double-blind, placebo-controlled, MAD study in healthy male and female adult subjects. The study will include up to 48 subjects (12 subjects per cohort) who will be randomized 9:3 to active drug or placebo. Each cohort will receive AZD4041 or placebo in a MAD study. A sequential cohort MAD design will be employed to assure that higher doses are administered to healthy subjects only after lower doses have demonstrated an acceptable safety profile.... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
01/12/2022
Locations: Research Site, Laval, Quebec +1 locations
Conditions: Opioid Use Disorder (OUD)
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Antibiotic Treatment Of Staphylococcus Aureus In Stable People With CF
NCT04553419
Recruiting
This is a randomized, double-blinded study that aims to assess the effect of an oral antibiotic called Cephalexin (150 mg/kg/day) compared to placebo in clinically stable children with cystic fibrosis who have grown a bacteria called MSSA (methicillin-susceptible Staphylococcus aureus) over the course of 2 weeks. A sensitive technique called MBW (multiple breath washout) will be used to look at how well the participants lungs are functioning during the study and to see if the antibiotic improve... Read More
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
01/12/2022
Locations: BC Children's Hospital, Vancouver, British Columbia +1 locations
Conditions: Cystic Fibrosis
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Canadian Cohort of Convective Thermal Therapy Using Rezūm System in Benign Prostatic Hyperplasia (BPH).
NCT05201131
Recruiting
To document the clinical outcome of Rezūm therapy for BPH patient in Canadian cohort.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/07/2022
Locations: Dean Elterman, Toronto, Ontario
Conditions: Urologic Diseases
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Canadian Observational Study Evaluating the Long-term IMPACT of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators on People With CF
NCT05200429
Recruiting
This observational study intends to investigate health trends and data in cystic fibrosis patients all across Canada that are receiving modulator treatment so researchers can determine if CFTR treatments are effective over a long period of time and if so, which treatments work best for each individual. The study will collect clinical data from routine standard of care, patient reported outcomes via survey data and samples for a biobank.
Gender:
ALL
Ages:
All
Trial Updated:
01/06/2022
Locations: British Columbia Children's Hospital, Vancouver, British Columbia +1 locations
Conditions: Cystic Fibrosis
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Aquablation in Benign Prostatic Hyperplasia in Canada
NCT05169892
Recruiting
To document the clinical outcome of Aquablation therapy for BPH patient in Canadian cohort.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/09/2021
Locations: Dean Elterman, Toronto, Ontario
Conditions: Urologic Diseases
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Using Antibiotics Wisely - An Antimicrobial Stewardship Program
NCT04388293
Recruiting
There are significant variations in antimicrobial consumption across Canadian Neonatal Intensive Care Units (NICUs). Inappropriate and overuse of antibiotics can result in antimicrobial resistance and adverse outcomes among vulnerable neonatal populations. There are limited data on broad-spectrum antimicrobial use, multi-drug resistant organisms (MDRO) prevalence, and effective NICU-specific antimicrobial stewardship strategies. The aim of this study is to develop and implement NICU-specific ant... Read More
Gender:
ALL
Ages:
Between 22 weeks and 44 weeks
Trial Updated:
12/07/2021
Locations: Royal Alexandra Hospital, Edmonton, Alberta
Conditions: Multi-Drug Resistant Organisms, Late-Onset Sepsis, Neonatal, Antimicrobial Resistance
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TARGet Kids!: Measuring Nutrition in Young Preschool Children in the Primary Care Practice Setting
NCT01869530
Recruiting
TARGet Kids! (The Applied Research Group for Kids) is a research study enrolling healthy children aged 0-5 years. The aim of the TARGet Kids! registry is to link early life exposures to health problems including obesity, micronutrient deficiencies, and developmental problems. TARGet Kids! represents an innovative collaboration between child health researchers and children's primary care doctors (pediatricians and family physicians) to promote research that really matters and create solutions to... Read More
Gender:
ALL
Ages:
5 years and below
Trial Updated:
11/09/2021
Locations: St. Michael's Hospital, Toronto, Ontario +2 locations
Conditions: Nutritional Disorders, Obesity, Development
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Bilateral Essential Tremor Treatment With Gamma Knife
NCT04748640
Recruiting
Combined Phase II/III, multi-center, prospective, single-blinded trial. Ten (10) patients with essential tremor who previously underwent successful and uncomplicated GK thalamotomy for essential tremor will undergo a contralateral treatment. The incidence of side effects will be determined at 3 months postoperatively, graded per the CTCAE v5 and analyzed by a data safety monitoring board. Upon successful review, this Phase II trial will be converted to a Phase III trial of utility that will enr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2021
Locations: Toronto Western Hospital, University Health Network, Toronto, Ontario +1 locations
Conditions: Essential Tremor
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Left vs. Right Non-Inferiority Trial
NCT04999553
Recruiting
The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established intermittent thetaburst rTMS (iTBS) treatment for treatment resistant depression (TRD).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/08/2021
Locations: Non-Invasive Neurostimulation Therapies Centre, University of British Columbia, Vancouver, British Columbia +1 locations
Conditions: Depression, Major Depressive Disorder, Major Depressive Episode
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Robotic Evaluations of Motor Learning During Stroke Neurorehabilitation
NCT05106140
Recruiting
The RELEARN trial is a a prospective longitudinal cohort study sampled by convenience. Stroke survivors and healthy control individuals will be recruited to analyze motor learning in the upper extremity and its neural basis in early stroke recovery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/02/2021
Locations: Carewest Dr. Vernon Fanning Centre, Calgary, Alberta +3 locations
Conditions: Stroke
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Imaging Measures of Respiratory Health Registry
NCT05102825
Recruiting
This is a prospective, observational cohort registry that aims to collect data on pulmonary structure and function in healthy people and those with respiratory disease, using structural and functional pulmonary 1H-MRI and hyperpolarized 129Xe-MRI. Outcome measures generated from MRI may include but are not limited to measures of regional ventilation, pulmonary microarchitecture, and regional gas exchange. Additionally, one of the goals of the registry is to facilitate the development of novel i... Read More
Gender:
ALL
Ages:
Between 0 years and 99 years
Trial Updated:
10/29/2021
Locations: British Columbia Children's Hospital, Vancouver, British Columbia +1 locations
Conditions: Respiratory Disease, Healthy
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