All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Incomplete Cervical SCI Without Instability

NCT05653206

Recruiting

A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of administering a set of additional core and optional outcome assessments in cervical SCI patients to capture the aspects of neurologic impairment. Baseline, intraoperative, and postoperative characteristics, including demographics, injury details, treatment details, neurological ass... Read More

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

07/23/2025

Locations: San Francisco General Hospital, San Francisco, California +9 locations

Conditions: Cervical Spinal Cord Injury

Learn More ›

Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression

NCT07094789

Recruiting

The goal of this clinical trial is to evaluate the safety and initial effectiveness of Magnetic Resonance-guided focused ultrasound neuromodulation using the Next Generation Dome Helmet (NGDH) device in patients with treatment-resistant depression. This is a prospective, single-arm, non-randomized study. Participants will: * Undergo two focused ultrasound treatment sessions targeting nodes of the cortical-striatal-thalamic circuit (CSTC) , spaced four weeks apart. * Return for follow-up visits... Read More

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

07/23/2025

Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario

Conditions: Treatment-Resistant Depression, Treatment-resistant Depression (TRD)

Learn More ›

Prostate Active Surveillance Study

NCT00756665

Recruiting

The Prostate Active Surveillance Study (PASS) is a research study for men who have chosen active surveillance as a management plan for their prostate cancer. Active surveillance is defined as close monitoring of prostate cancer with the offer of treatment if there are changes in test results. This study seeks to discover markers that will identify cancers that are more aggressive from those tumors that grow slowly.

Gender:

MALE

Ages:

21 years and above

Trial Updated:

07/23/2025

Locations: Veterans Affairs San Francisco Health Care System, San Francisco, California +10 locations

Conditions: Prostatic Neoplasms

Learn More ›

Radioembolization Trial Utilizing Eye90 Microspheres™ for the Treatment of Hepatocellular Carcinoma (HCC)

NCT05953337

Recruiting

This is a prospective, multi-center, open-label study to evaluate the effectiveness and safety of Eye90 microspheres® in the treatment of subjects with unresectable Hepatocellular Carcinoma (HCC). Eye90 microspheres is a medical device containing yttrium-90 (Y-90), a radioactive material, and provides local radiation brachytherapy for the treatment of liver tumors.

Gender:

ALL

Ages:

Between 18 years and 99 years

Trial Updated:

07/23/2025

Locations: The University of Arizona Cancer Center, Tucson, Arizona +20 locations

Conditions: Hepatocellular Carcinoma, Hepatocellular Carcinoma Non-resectable, Liver Cancer

Learn More ›

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

NCT06764485

Recruiting

The purpose of this study is to compare the efficacy and safety of BMS-986365 versus the investigator's choice of therapy in participants with Metastatic Castration-resistant Prostate Cancer.

Gender:

MALE

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: Local Institution - 0330, Birmingham, Alabama +247 locations

Local Institution - 0330, Birmingham, Alabama

Banner MD Anderson Cancer Center, Gilbert, Arizona

Los Angeles Cancer Network (LACN), Anaheim, California

Moores Cancer Center, La Jolla, California

Cancer and Blood Specialty Clinic, Los Alamitos, California

Local Institution - 0364, Los Angeles, California

Pacific Hematology Oncology Associates, San Francisco, California

Local Institution - 0411, San Francisco, California

Local Institution - 0238, Aurora, Colorado

Rocky Mountain Cancer Centers, LLP, Denver, Colorado

Local Institution - 0419, Lakewood, Colorado

Sibley Memorial Hospital, Washington, District of Columbia

Local Institution - 0426, Lakeland, Florida

University Cancer & Blood Center, LLC, Athens, Georgia

Local Institution - 0048, Chicago, Illinois

The University of Kansas Cancer Center - Westwood, Westwood, Kansas

Wichita Urology Group, Wichita, Kansas

Johns Hopkins Hospital, Baltimore, Maryland

Local Institution - 0344, Frederick, Maryland

Local Institution - 0054, Towson, Maryland

Local Institution - 0104, Minneapolis, Minnesota

Local Institution - 0049, Las Vegas, Nevada

Local Institution - 0429, Sewell, New Jersey

University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico

New Mexico Oncology Hematology Consultants Ltd., Albuquerque, New Mexico

Local Institution - 0197, Buffalo, New York

Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York

Laura and Isaac Perlmutter Cancer Center, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Local Institution - 0085, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Associated Medical Professionals - Urology, Syracuse, New York

Local Institution - 0056, Columbus, Ohio

Providence Portland Medical Center, Portland, Oregon

Providence St. Vincent Medical Center, Portland, Oregon

Local Institution - 0345, Philadelphia, Pennsylvania

Local Institution - 0414, Philadelphia, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Local Institution - 0349, Willow Grove, Pennsylvania

Local Institution - 0055, Charleston, South Carolina

Carolina Urologic Research Center, LLC, Myrtle Beach, South Carolina

Tennessee Oncology, Nashville, Tennessee

Local Institution - 0114, Austin, Texas

Texas Oncology - Central/South Texas, Austin, Texas

Local Institution - 0220, Houston, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

Intermountain Medical Center, Murray, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

Local Institution - 0023, Richmond, Virginia

Local Institution - 0078, Seattle, Washington

Northwest Cancer Specialists, P.C., Vancouver, Washington

Local Institution - 0112, Milwaukee, Wisconsin

Hospital Británico de Buenos Aires, Caba, Buenos Aires

Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires

Local Institution - 0128, ABB, Ciudad Autónoma De Buenos Aires

Hospital Italiano de Córdoba, Cordoba, Córdoba

Local Institution - 0130, Río Cuarto, Córdoba

Clinica Viedma S. A, Viedma, R

Asociación de Beneficencia Hospital Sirio Libanés, Buenos Aires, Not set

GenesisCare - Campbelltown, Campbelltown, New South Wales

St Vincent's Hospital, Darlinghurst, New South Wales

Macquarie University, Macquarie University, New South Wales

Port Macquarie - Mid North Coast Cancer Institute, Port Macquarie, New South Wales

Sydney Adventist Hospital, Wahroonga, New South Wales

Greenslopes Private Hospital - Gallipoli Medical Research Foundation, Greenslopes, Queensland

Tasman Oncology Research, Southport, Queensland

Royal Adelaide Hospital, Adelaide, South Australia

Lyell McEwin Hospital, Elizabeth Vale, South Australia

ICON Cancer Centre - Kurralta Park, Kurralta Park, South Australia

Icon Cancer Centre Hobart, Hobart, Tasmania

Austin Health, Heidelberg, Victoria

Cabrini Hospital - Malvern, Malvern, Victoria

Peter MacCallum Cancer Centre, Melbourne, Victoria

The Alfred Hospital, Melbourne, Victoria

St. John of God Murdoch Hospital, Murdoch, Western Australia

Universitätsklinikum Krems, Krems, Niederösterreich

Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich

Local Institution - 0367, Salzburg, Not set

Medizinische Universität Wien, Wien, Not set

Local Institution - 0039, Vitória, Espírito Santo

Local Institution - 0025, Belo Horizonte, Minas Gerais

Local Institution - 0035, Natal, Rio Grande Do Norte

Local Institution - 0026, Porto Alegre, Rio Grande Do Sul

Local Institution - 0395, Sao Paulo, São Paulo

Local Institution - 0031, Sao Paulo, São Paulo

Local Institution - 0304, Kelowna, British Columbia

BC Cancer Vancouver, Vancouver, British Columbia

Local Institution - 0151, Halifax, Nova Scotia

Local Institution - 0193, Toronto, Ontario

CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec

Local Institution - 0149, Montreal, Quebec

Local Institution - 0305, Montréal, Quebec

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Quebec City, Quebec

Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski, Quebec

Local Institution - 0236, Valdivia, Los Rios

Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago

Bradfordhill, Santiago, Región Metropolitana De Santiago

Oncocentro Apys, Viña del Mar, Valparaíso

Local Institution - 0232, Hefei, Anhui

Local Institution - 0168, Beijing, Beijing

Local Institution - 0192, Beijing, Beijing

Local Institution - 0176, Beijing, Beijing

Local Institution - 0237, Chongqing, Chongqing

Local Institution - 0249, Fuzhou, Fujian

Local Institution - 0213, Xiamen, Fujian

Local Institution - 0226, Guangzhou, Guangdong

Local Institution - 0180, Guangzhou, Guangdong

Local Institution - 0415, Huizhou, Guangdong

Local Institution - 0222, Harbin, Heilongjiang

Local Institution - 0211, Zhengzhou, Henan

Local Institution - 0279, Zhengzhou, Henan

Local Institution - 0284, Wuhan, Hubei

Local Institution - 0216, Changsha, Hunan

Local Institution - 0217, Changsha, Hunan

Local Institution - 0417, Changzhou, Jiangsu

Local Institution - 0233, Nanjing, Jiangsu

Local Institution - 0228, Nanjing, Jiangsu

Local Institution - 0229, Nanjing, Jiangsu

Local Institution - 0219, Nanchang, Jiangxi

Local Institution - 0198, Xi'an, Shaanxi

Local Institution - 0191, Jinan, Shandong

Local Institution - 0221, Yantai, Shandong

Local Institution - 0300, Shanghai, Shanghai

Local Institution - 0212, Shanghai, Shanghai

Local Institution - 0214, Shanghai, Shanghai

Local Institution - 0215, Shanghai, Shanghai

Local Institution - 0308, Shanghai, Shanghai

Local Institution - 0205, Taiyuan, Shanxi

Local Institution - 0278, Cheng Du, Sichuan

Local Institution - 0240, Chengdu, Sichuan

Local Institution - 0283, Chengdu, Sichuan

Local Institution - 0218, Urumqi, Xinjiang

Local Institution - 0181, Hangzhou, Zhejiang

Local Institution - 0196, Hangzhou, Zhejiang

Local Institution - 0280, Hangzhou, Zhejiang

Local Institution - 0281, Linhai, Zhejiang

Local Institution - 0223, Wenzhou, Zhejiang

Local Institution - 0011, Horovice, Beroun

Masarykuv onkologicky ustav, Brno, Brno-město

Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové

Fakultni nemocnice Olomouc, Olomouc, Olomoucký Kraj

Local Institution - 0009, Prague, Praha 2

Local Institution - 0418, Prague, Praha 4

Fakultni nemocnice v Motole, Praha, Praha 5

Local Institution - 0006, Praha 2, Not set

Herlev and Gentofte Hospital, Copenhagen, Hovedstaden

Rigshospitalet, Copenhagen, Hovedstaden

Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland

Aalborg Universitetshospital, Syd, Aalborg, Nordjylland

Local Institution - 0167, Nice, Alpes-Maritimes

Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg, Alsace

Oncopole Claudius Regaud, Toulouse, Haute-Garonne

Institut de Cancérologie de Lorraine Alexis Vautrin, Vandoeuvre-lès-Nancy, Lorraine

Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône

Clinique Victor Hugo Le Mans, Le Mans, Sarthe

Local Institution - 0179, Villejuif, Val-de-Marne

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne, Clermont-Ferrand, Not set

Local Institution - 0178, Paris, Not set

Local Institution - 0421, Nürtingen, Baden-Württemberg

TUM Universitätsklinikum, Technische Universität München, München, Bayern

Universitätsklinikum Schleswig-Holstein, Lübeck, Schleswig-Holstein

Universitätsklinikum Jena, Jena, Thüringen

Local Institution - 0382, Bonn, Not set

Universitaetsklinikum Essen, Essen, Not set

Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Not set

Universitaetsklinikum Heidelberg, Heidelberg, Not set

Marienhospital Herne, Herne, Not set

Universitaetsklinikum Tuebingen, Tübingen, Not set

Universitaetsklinikum Wuerzburg, Wuerzburg, Not set

Local Institution - 0271, Cork, Not set

Tallaght University Hospital, Dublin, Not set

Beaumont Hospital, Dublin, Dublin, Not set

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia

Local Institution - 0234, Orbassano, Piemonte

Local Institution - 0155, Rome, Roma

Local Institution - 0153, Padova, Veneto

Azienda USL 8 di Arezzo, Arezzo, Not set

Local Institution - 0424, Catania, Not set

Azienda Ospedaliero Universitaria Policlinico Riuniti di Foggia, Foggia, Not set

Local Institution - 0425, Milano, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Not set

Azienda Ospedaliera Santa Maria Terni, Terni, Not set

APSS- Presidio Ospedaliero S. Chiara, Trento, Not set

National Cancer Center, Goyang-si, Kyǒnggi-do

Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do

Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]

Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 0346, Wroclaw, Dolnośląskie

Państwowy Instytut Medyczny MSWiA, Warszawa, Mazowieckie

SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu, Opole, Opolskie

COPERNICUS PL, Wojewodzkie Centrum Onkologii, Gdansk, Pomorskie

Pratia Poznań, Poznań, Wielkopolskie

Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set

Local Institution - 0336, Katowice, Not set

Regional Specialised Hospital No. 4 in Bytom, Bytom, Śląskie

BRCR Global - Mayagüez, Mayaguez, Not set

Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj

Spitalul Municipal Schuller Ploiești, Ploiești, Prahova

Institutul Oncologic Cluj, Cluj, Not set

Spitalul Universitar C.F. Cluj-Napoca, Cluj, Not set

Institutul Regional de Oncologie, Iași, Not set

Local Institution - 0275, Banska Bystrica, Banskobystrický Kraj

Local Institution - 0381, Prešov, Prešovský Kraj

Local Institution - 0201, Bratislava, Not set

Local Institution - 0200, Martin, Žilinský Kraj

Hospital Universitario Reina Sofia, Cordoba, Andalucía

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Hospital Universitari Parc Tauli, Sabadell, Barcelona [Barcelona]

OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, Bizkaia

Local Institution - 0314, Santander, Cantabria

Local Institution - 0315, Barcelona, Catalunya [Cataluña]

Local Institution - 0319, Lugo, Lugo [Lugo]

Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad De

Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De

Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De

Hospital Universitario La Paz, Madrid, Madrid, Comunidad De

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De

Complejo Hospitalario de Navarra, Pamplona, Navarra

Complexo Hospitalario Universitario de Ourense, Ourense, Ourense [Orense]

Hospital Infanta Cristina, Badajoz, Not set

Hospital Universitario de Burgos, Burgos, Not set

Hospital Vithas La Salud, Granada, Not set

Hospital Clinico San Carlos, Madrid, Not set

Local Institution - 0327, Málaga, Not set

Hospital Universitario Virgen Macarena, Sevilla, Not set

Hospital Universitario Virgen Del Rocio, Sevilla, Not set

Local Institution - 0324, València, Not set

Local Institution - 0099, Lund, Skåne Län [se-12]

Karolinska Universitetssjukhuset Solna, Solna, Stockholms Län [se-01]

Akademiska sjukhuset, Uppsala, Uppsala Län [se-03]

Sahlgrenska Universitetssjukhuset, Gothenburg, Västra Götalands Län [se-14]

China Medical University Hospital, Taichung, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Local Institution - 0420, Taoyuan, Not set

Local Institution - 0340, Adana, Not set

Local Institution - 0339, Ankara, Not set

Local Institution - 0338, Ankara, Not set

Local Institution - 0341, Ankara, Not set

Local Institution - 0337, Istanbul, Not set

Local Institution - 0342, Istanbul, Not set

The Beatson West of Scotland Cancer Centre, Glasgow, Glasgow City

Mount Vernon Hospital, Northwood, Hillingdon

St Bartholomew's Hospital, London, London, City Of

Royal Marsden Hospital (Sutton), London, Sutton

The Christie NHS Foundation Trust, Manchester, Not set

Conditions: Metastatic Castration-resistant Prostate Cancer

Learn More ›

An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment

NCT06883240

Recruiting

This non-interventional study (NIS) is designed to collect information on the effectiveness and safety of treatment received in routine clinical care, as well as measure the health-related quality of life (HRQoL) of participants with Type 3 von Willebrand disease (VWD) receiving prophylactic therapy per local standard of care (SOC) over an observation period of at least 24 weeks.

Gender:

ALL

Ages:

2 years and above

Trial Updated:

07/23/2025

Locations: UZ Leuven Gasthuisberg, Leuven, Not set +17 locations

Conditions: Von Willebrand Disease, Type 3

Learn More ›

Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

NCT05386394

Recruiting

While many have strongly suggested that transcranial direct current stimulation (tDCS) may represent a beneficial intervention for patients with primary progressive aphasia (PPA), this promising technology has not yet been applied widely in clinical settings. This treatment gap is underscored by the absence of any neurally-focused standard-of-care treatments to mitigate the devastating impact of aphasia on patients' family, work, and social lives. Given that tDCS is inexpensive, easy to use (it... Read More

Gender:

ALL

Ages:

Between 50 years and 90 years

Trial Updated:

07/23/2025

Locations: Johns Hopkins Hospital, Baltimore, Maryland +2 locations

Conditions: Primary Progressive Aphasia, Logopenic Progressive Aphasia, Non-Fluent Primary Progressive Aphasia

Learn More ›

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

NCT06428396

Recruiting

The purpose of this study is to assess the efficacy and safety of belzutifan (MK-6482) plus fulvestrant compared to everolimus plus endocrine therapy (ET) (investigator's choice of fulvestrant or exemestane) in adults with estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) unresectable metastatic breast cancer. There is no formal hypothesis testing in this study.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: City of Hope - Phoenix ( Site 0006), Goodyear, Arizona +35 locations

City of Hope - Phoenix ( Site 0006), Goodyear, Arizona

Cedars Sinai Medical Center ( Site 0012), Beverly Hills, California

Moores Cancer Center at UC San Diego Health ( Site 0025), La Jolla, California

USC/Norris Comprehensive Cancer Center ( Site 0013), Los Angeles, California

USC Norris Oncology Hematology Newport Beach ( Site 0029), Newport Beach, California

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0011), Marietta, Georgia

Southeastern Regional Medical Center ( Site 0010), Newnan, Georgia

CHRISTUS Highland ( Site 0005), Shreveport, Louisiana

Renown Regional Medical Center ( Site 0018), Reno, Nevada

Mays Cancer Center ( Site 0022), San Antonio, Texas

Centro de Investigaciones Metabólicas (CINME)-Oncology ( Site 0504), Caba, Buenos Aires

Hospital Británico de Buenos Aires-Oncology ( Site 0500), Ciudad autónoma de Buenos Aires, Buenos Aires

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0502), Mar del Plata, Buenos Aires

Instituto Alexander Fleming-Alexander Fleming ( Site 0505), Ciudad Autónoma de Buenos Aires, Caba

Sanatorio Allende - Cerro-Oncology ( Site 0506), Córdoba, Cordoba

Instituto de Oncología de Rosario ( Site 0501), Rosario, Santa Fe

Jewish General Hospital ( Site 0400), Montreal, Quebec

Centro de Investigación del Maule ( Site 4106), Talca, Maule

Bradfordhill ( Site 4100), Santiago., Region M. De Santiago

FALP ( Site 4102), Santiago, Region M. De Santiago

Pontificia Universidad Catolica de Chile ( Site 4108), Santiago, Region M. De Santiago

IMAT S.A.S ( Site 1205), Monteria, Cordoba

Oncologos Del Occidente ( Site 1200), Pereira, Risaralda

Fundacion Valle del Lili ( Site 1204), Cali, Valle Del Cauca

Seoul National University Hospital ( Site 3100), Seoul, Not set

Samsung Medical Center ( Site 3101), Seoul, Not set

National Cheng Kung University Hospital ( Site 3300), Tainan, Not set

National Taiwan University Hospital ( Site 3301), Taipei, Not set

National Taiwan University Cancer Center ( Site 3302), Taipei, Not set

Faculty of Medicine - Khon Kaen University ( Site 3502), Muang, Khon Kaen

Faculty of Medicine Siriraj Hospital ( Site 3500), Bangkoknoi, Krung Thep Maha Nakhon

Songklanagarind Hospital ( Site 3501), Hat Yai, Songkhla

The Royal Cornwall Hospital ( Site 1904), Truro, England

St Bartholomews Hospital ( Site 1900), London, London, City Of

The Christie Hospital NHS Foundation Trust ( Site 1902), Withington, Manchester

Ipswich Hospital ( Site 1911), Ipswich, Suffolk

Conditions: Metastatic Breast Cancer

Learn More ›

Enhancing Internet-Delivered Cognitive Behaviour Therapy With Additional Content

NCT07095582

Recruiting

This study evaluates the effectiveness of additional content on loneliness offered alongside the Wellbeing Course - an internet-delivered cognitive behavioral therapy (ICBT) intervention for symptoms of depression and anxiety- in improving treatment outcomes for individuals with elevated scores on loneliness seeking treatment for depression and anxiety at a routine care online therapy clinic (the Online Therapy Unit). In this partially randomized control trial, the investigators aim to contribut... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: Online Therapy Unit, Regina, Saskatchewan +1 locations

Conditions: Loneliness, Depression, Anxiety

Learn More ›

Using a Blood Test to Monitor Metastatic Breast Cancer Treatment

NCT05804578

Recruiting

The goal of this observational study is to assess the effectiveness of the mDETECT breast cancer blood test at monitoring treatment response in women with metastatic breast cancer undergoing treatment.

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

07/22/2025

Locations: Kingston Health Sciences Centre - Cancer Centre of Southeastern Ontario, Kingston, Ontario +1 locations

Conditions: Metastatic Breast Cancer

Learn More ›

Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

NCT04634240

Recruiting

Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty about the benefits and the optimal timing of revascularization for such patients. There is currently clinical equipoise regarding the management of concomitant CAD in patients undergoing TAVR. Some centers perform routine revascularization with percutaneous coronary intervention (PCI) (either before or after TAVR), while others follow an alternative strategy of medical management. The potential benefits and optimal timing of PCI in these patients are unknown. As TAVR expands to lower risk patients, and potentially becomes the preferred therapy for the majority of patients with severe aortic stenosis, the optimal management of concomitant coronary artery disease will be of increasing importance. The COMPLETE TAVR study will determine whether, on a background of guideline-directed medical therapy, a strategy of complete revascularization involving staged PCI using drug eluting stents to treat all suitable coronary artery lesions is superior to a strategy of medical therapy alone in reducing the composite outcome of Cardiovascular Death, new Myocardial Infarction, Ischemia-driven Revascularization or Hospitalization for Unstable Angina or Heart Failure. The study will be a randomized, multicenter, open-label trial with blinded adjudication of outcomes. Patients will be screened and consented for elective transfemoral TAVR and randomized within 96 hours of successful balloon expandable TAVR. Complete Revascularization: Staged PCI using third generation drug eluting stents to treat all suitable coronary artery lesions in vessels that are at least 2.5 mm in diameter and that are amenable to treatment with PCI and have a ≥70% visual angiographic diameter stenosis. Staged PCI can occur any time from 1 to 45 days post successful transfemoral TAVR. Vs. Medical Therapy Alone: No further revascularization of coronary artery lesions. All patients, regardless of randomized treatment allocation, will receive guideline-directed medical therapy consisting of risk factor modification and use of evidence-based therapies. The COMPLETE TAVR study will help address the current lack of evidence in this area. It will likely impact both the global delivery of health care and the management and clinical outcomes of all patients undergoing TAVR with concomitant CAD. Read Less

Gender:

ALL

Ages:

All

Trial Updated:

07/22/2025

Locations: Huntsville Heart Center, Huntsville, Alabama +71 locations

Huntsville Heart Center, Huntsville, Alabama

Arizona Cardiovascular Research, Phoenix, Arizona

Veteran Affairs Palo Alto Health Care System, Palo Alto, California

Loma Linda University, Redlands, California

Santa Barbara Cottage Hospital, Santa Barbara, California

Torrance Memorial Medical Center, Torrance, California

JFK Medical Center, Atlantis, Florida

Baptist Health Jacksonville, Jacksonville, Florida

Miami Cardiac and Vascular/Baptist Hospital, Miami, Florida

Piedmont, Atlanta, Georgia

Northeast Georgia Health System, Gainesville, Georgia

St. Alphonsus Regional Medical Center, Boise, Idaho

Ascension Alexian Brothers, Chicago, Illinois

Midwest Cardiovascular Research and Education Foundation, Elkhart, Indiana

Parkview Research Center, Fort Wayne, Indiana

University of Kansas Medical Center, Kansas City, Kansas

Midwest Heart and Vascular, Overland Park, Kansas

Cardiovascular Research Institute of Kansas, Wichita, Kansas

Tufts Medical, Boston, Massachusetts

Massachusetts General Hospital, Boston, Massachusetts

Sparrow Clinical Research Institute, Lansing, Michigan

William Beaumont Hospital, Royal Oak, Michigan

Ascension St. Mary's, Saginaw, Michigan

St. Joseph Mercy Health System, Ypsilanti, Michigan

University of Minnesota Medical Center, Minneapolis, Minnesota

CentraCare Heart and Vascular Center, Saint Cloud, Minnesota

Boone Hospital, Columbia, Missouri

St. Louis University, Saint Louis, Missouri

Missouri Baptist, Saint Louis, Missouri

Bryan Heart, Lincoln, Nebraska

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Our Lady of Lourdes, Camden, New Jersey

Valley Hospital, Ridgewood, New Jersey

Montefiore Medical Center, Bronx, New York

University at Buffalo, Buffalo, New York

NYU Langone Hospital - Long Island, Mineola, New York

Mount Sinai, New York, New York

Columbia University Medical Center, New York, New York

St. Joseph's Hospital, Syracuse, New York

Novant Health Heart and Vascular Institute, Charlotte, North Carolina

Summa Health System, Akron, Ohio

Mount Carmel, Columbus, Ohio

Oklahoma Heart, Oklahoma City, Oklahoma

Kaiser Permanente Northwest, Clackamas, Oregon

Rhode Island Hospital, Providence, Rhode Island

Methodist Le Bonheur Healthcare, Germantown, Tennessee

Ballad Health CVA Heart Institute, Kingsport, Tennessee

Parkwest Medical Center, Knoxville, Tennessee

Cardiovascular Surgery Clinic/Baptist Memorial, Memphis, Tennessee

HCA Houston Healthcare Medical Center, Houston, Texas

Baylor Scott & White Plano, Plano, Texas

Baylor Scott & White Round Rock, Round Rock, Texas

University of Vermont Medical Center, Burlington, Vermont

Bellin Health System, Green Bay, Wisconsin

Ascension Columbia St. Mary's, Milwaukee, Wisconsin

University of Alberta, Mazankowski Heart Institute, Edmonton, Alberta

Royal Columbian Hospital, New Westminster, British Columbia

Vancouver General Hospital, Vancouver, British Columbia

Centre for Cardiovascular Innovation-Centre d'Innovation Cardiovasculaire (CCI-CIC), Vancouver, British Columbia

St. Paul's Hospital, Vancouver, British Columbia

Saint Boniface, Winnipeg, Manitoba

New Brunswick Heart, Saint John, New Brunswick

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia

Hamilton Health Sciences, Hamilton, Ontario

Ottawa Heart, Ottawa, Ontario

Sunnybrook Hospital, Toronto, Ontario

St. Michael's Hospital, Toronto, Ontario

Montréal Heart, Montréal, Quebec

Centre Hospitalier de l'Université de Montréal, Montréal, Quebec

Sacré-Coeur, Montréal, Quebec

CIUSSS de l'Estrie-CHUS, Sherbrooke, Quebec

Prairie Vascular, Regina, Saskatchewan

Conditions: Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis

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Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy

NCT06568042

Recruiting

The purpose of this study is to evaluate how safe and how well a treatment works compared to placebo for people with nerve pain that begins in their feet and moves up the leg to just below the knee. Participation may last up to 30 weeks including screening.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/22/2025

Locations: MD First Research - Chandler, Chandler, Arizona +80 locations

MD First Research - Chandler, Chandler, Arizona

HOPE Research Institute, Phoenix, Arizona

Neuro-Pain Medical Center, Fresno, California

Alpine Clinical Research Center, Boulder, Colorado

Accel Research Sites - St. Pete-Largo Clinical Research Unit, Largo, Florida

Design Neuroscience Center, Miami Lakes, Florida

Conquest Research - Orlando, Orlando, Florida

Charter Research - Lady Lake, The Villages, Florida

Encore Medical Research - Weston, Weston, Florida

Conquest Research, Winter Park, Florida

Integrated Clinical Trial Services, Inc., West Des Moines, Iowa

Lucida Clinical Trials, New Bedford, Massachusetts

SKY Integrative Medical Center/SKYCRNG, Ridgeland, Mississippi

StudyMetrix Research, Saint Peters, Missouri

Mid Hudson Medical Research, New Windsor, New York

University of Rochester Medical Center, Rochester, New York

Asheville Neurology Specialists, PA, Asheville, North Carolina

Center for Clinical Research, Winston-Salem, North Carolina

Neurology Diagnostics, Inc., Dayton, Ohio

New Phase Research and Development, Knoxville, Tennessee

Cedar Health Research, Dallas, Texas

Biopharma Informatic, LLC, Houston, Texas

Clinical Trial Network, Houston, Texas

Northwest Clinical Research Center, Bellevue, Washington

OCT Research ULC, Kelowna, British Columbia

Richmond Clinical Trials, Richmond, British Columbia

Med Trust Research, Courtice, Ontario

Dawson Clinical Research Inc., Guelph, Ontario

Premier Clinical Trial Network, Hamilton, Ontario

Bluewater Clinical Research Group Inc., Sarnia, Ontario

Genge Partners, Montreal, Quebec

MUDr. Alena Vachova, Ceske Budejovice, Jihočeský Kraj

MUDr. Miroslav Koliba s.r.o., Ostrava, Ostrava Město

NEUROS s.r.o., Pilsen, Plzeň-město

Milan Kvapil s.r.o., Diabetologicka ambulance, Praha, Praha 4

Praglandia s.r.o, Praha 5, Not set

Studienzentrum Dr. Bischof GmbH, Boeblingen, Baden-Württemberg

Studienzentrum Nord-West, Westerstede, Niedersachsen

ZNS Siegen, Siegen, Nordrhein-Westfalen

Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein

emovis GmbH, Berlin, Not set

Kamezawa Clinic, Kasugai, Aichi

Kojunkai Daido Hospital, Nagoya, Aichi

Kikuchi Naika Clinic, Maebashi, Gunma

Chugoku Central Hospital, Fukuyama-shi, Hiroshima

Nishinomiya Municipal Central Hospital, Nishinomiya, Hyogo

Mito Medical Center, Higashiibaraki, Ibaraki

Aizawa Hospital, Matsumoto, Nagano

Asama General Hospital, Saku, Nagano

Rinku General Medical Center, Izumisano, Osaka

Saga-Ken Medical Centre Koseikan, Saga-shi, Saga

St. Luke's International Hospital, Chuo-ku, Tokyo

The Cancer Institute Hospital of JFCR, Koto, Tokyo

Medical Corporation Sato Medical clinic, Ootaku, Tokyo

Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo

Sagara Hospital, Kagoshima, Not set

Fujigaki Clinic, Oita, Not set

Minamiosaka Hospital, Osaka, Not set

Niwa Family Clinic, Tokyo, Not set

Chosun University Hospital, Gwangju, Kwangju-Kwangyǒkshi

Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]

Konkuk University Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Grupo Medico Camino Sc, Mexico City, Distrito Federal

Centro de Investigación Clínica y Medicina Traslacional (CIMeT), Guadalajara, Jalisco

Cicmex Centro de Investigación Clínica de México, Morelia, Michoacán

Investigación Clínica Cuernavaca, S.C., Cuernavaca, Morelos

Centro de Investigacion Clinica de Oaxaca, Oaxaca de Juarez, Oaxaca

Health Pharma Querétaro, Juriquilla, Querétaro

Medical Care and Research SA de CV, Merida, Yucatán

Scientia Investigacion Clinica S.C., Chihuahua, Not set

Centrum Medyczne NEUROMED, Bydgoszcz, Kujawsko-pomorskie

MICS Centrum Medyczne Warszawa, Warszawa, Mazowieckie

Diamond Clinic, Krakow, Małopolskie

Podlaskie Centrum Psychogeriatrii, Białystok, Podlaskie

Centrum Badan Klinicznych PI-House sp. z o.o., Gdansk, Pomorskie

Nzoz Neuro-Kard Ilkowski i Partnerzy SPL, Poznan, Wielkopolskie

Santa Familia PTG Lodz, Lodz, Łódzkie

Neuro-Care Sp. z o.o. sp. kom., Katowice, Śląskie

Conditions: Neuropathic Pain, Distal Sensory Polyneuropathy

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