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                    All Clinical Trials in Canada
A listing of 3905  clinical trials  actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
            409 - 420 of 3905
        
                
                                    Adding Chondrus Crispus Seaweeds to a Meal: Effect on Sensory Perception, Physical Comfort, Satiety and Food Intake
                                
            
            
        Recruiting
                            
            
                The study investigates the sensory characteristics, consumer perception and the effect on satiety and food intake of the meal with added Chondrus crispus seaweed produced by Acadian Seaplants in Atlantic Canada.             
        
        
    Gender:
                MALE
            Ages:
                Between 19 years and 35 years
            Trial Updated:
                08/11/2025
            
            Locations: Appetite Lab, Halifax, Nova Scotia         
        
        
            Conditions: Satiety and Food Intake, Sensory Evaluation, Physical Comfort
        
            
        
    
                
                                    LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery
                                
            
            
        Recruiting
                            
            
                To evaluate the percentage of subjects with AKI within 7 days following on-pump cardiac surgery defined by the KDIGO (Kidney Disease: Improving Global Outcomes) criteria:
1. Increase in baseline (pre-surgery) serum creatinine (SCr) by ≥26.5 μmol/L (≥0.3 mg/dL) within 7 days; OR
2. Increase in baseline SCr to ≥1.5 times baseline, which is known or presumed to have occurred within the first 7 days following surgery; OR
3. Urine output \< 0.5 mL/kg/h for \>6 hours.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: Cumming School of Medicine & Libin Cardiovascular Centre, University of Calgary, Calgary, Alberta  +7 locations         
        
        
            Conditions: Acute Kidney Injury, Cardiac Surgery
        
            
        
    
                
                                    A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome
                                
            
            
        Recruiting
                            
            
                The purpose of this study is to assess the safety and efficacy of two doses of Deucravacitinib in adult participants with Active Sjögren's Syndrome.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: Local Institution - 0228, Fullerton, California  +228 locations         
        
        
            Conditions: Sjögren's Syndrome
        
            
        
    
                
                                    Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
                                
            
            
        Recruiting
                            
            
                This is a Phase 3 global, multicenter, 52-week, open-label extension (OLE) rollover study for subjects completing study CN012-0026, CN012-0027 or CN012-0056. Subjects (randomized or non-randomized) who complete the 38-week CN012-0026 study, 14-week CN012-0027 study or 14-week CN012-0056 study will be eligible to enroll in CN012-0028.
The primary objective of the study is to assess the long-term safety and tolerability of KarXT in subjects with psychosis associated with Alzheimer's Disease.             
        
        
    Gender:
                ALL
            Ages:
                Between 55 years and 90 years
            Trial Updated:
                08/11/2025
            
            Locations: Local Institution - 1029, Homewood, Alabama  +382 locations         
        
        
            Conditions: Psychosis Associated With Alzheimer's Disease
        
            
        
    
                
                                    Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma
                                
            
            
        Recruiting
                            
            
                This study is being done to answer the following question: Can the addition of a new drug to the usual treatment lower the chance of primary central nervous system lymphoma growing or spreading?
This study is being done to find out if this approach is better or worse than the usual approach for this type of cancer. The usual approach is defined as the care most people get for Primary Central Nervous System Lymphoma (PCNSL).             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta  +6 locations         
        
        
            Conditions: Non-hodgkin Lymphoma
        
            
        
    
                
                                    Tracking Results of Ablations to Combat AF Registry Generation 2
                                
            
            
        Recruiting
                            
            
                The primary objective of the TRAC-AF Registry is to capture real-world safety and effectiveness data on AtriCure devices used to conduct concomitant open heart and/or hybrid ablation, and management of the Left Atrial Appendage concomitant to a cardiac ablation.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: Huntsville Hospital, Huntsville, Alabama  +22 locations         
        
        
            Conditions: Atrial Fibrillation
        
            
        
    
                
                                    A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
                                
            
            
        Recruiting
                            
            
                The purpose of this study is to establish the efficacy, safety and tolerability of barzolvolimab in adult participants with Chronic Spontaneous Urticaria (CSU) inadequately controlled by non-sedating second generation H1-antihistamines in comparison to placebo.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: Cahaba Dermatology Skin Health Center, Birmingham, Alabama  +219 locations         
        
        
            Conditions: Chronic Spontaneous Urticaria
        
            
        
    
                
                                    Type 1 Diabetes Virtual Self-management Education and Support
                                
            
            
        Recruiting
                            
            
                OVERVIEW: People living with type 1 diabetes (T1D) are expected to fit self-management and regular clinical consultations into busy lives. T1D self-management programs that offer frequent contact with care teams are most effective in helping patients achieve optimal glycemic control. However, this is difficult to deliver in the context of current T1D care which involves time-consuming in-person visits during working hours. The proposed study will test a virtual health care intervention to delive...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: Waterloo Regional Health Network, Kitchener, Ontario  +6 locations         
        
        
            Conditions: type1diabetes
        
            
        
    
                
                                    Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
                                
            
            
        Recruiting
                            
            
                This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.             
        
        
    Gender:
                ALL
            Ages:
                Between 18 years and 85 years
            Trial Updated:
                08/11/2025
            
            Locations: Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre, London, Ontario         
        
        
            Conditions: Cannabis Use, Cannabis Smoking, Marijuana Smoking, Marijuana Usage
        
            
        
    
                
                                    A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)
                                
            
            
        Recruiting
                            
            
                This study is to assess the effectiveness and safety of pacritinib in patients with VEXAS (i.e., Vacuoles in myeloid progenitors, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory manifestations, and somatic) syndrome. 78 patients will be enrolled, randomized to either pacritinib dose A, pacritinib dose B + placebo, or placebo. Randomization will be stratified by prescribed GC dose on the day of randomization.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: Mayo Clinic - Scottsdale, Scottsdale, Arizona  +39 locations         
        
        
            Conditions: VEXAS, VEXAS Syndrome
        
            
        
    
                
                                    LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
                                
            
            
        Recruiting
                            
            
                This study will evaluate the safety and efficacy of intravesical administration of EG-70 in the bladder and its effect on bladder tumors in patients with NMIBC.
This study study consists of two phases; a Phase 1 dose-escalation to establish safety and recommended the phase 2 dose, followed by a Phase 2 study to establish how effective the treatment is.
The Study will include patients with NMIBC with Cis for whom BCG therapy is unresponsive and patients with NMIBC with Cis who are BCG-naïve or...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: The University of Alabama at Birmingham Clinical Research Unit (CRU), Birmingham, Alabama  +98 locations         
        
        
            Conditions: Superficial Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
        
            
        
    
                
                                    A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
                                
            
            
        Recruiting
                            
            
                An open-label, controlled, multi-site, interventional, 2-arm, Phase II/III trial of BNT113 in combination with pembrolizumab vs pembrolizumab monotherapy as first line treatment in patients with unresectable recurrent or metastatic HPV16+ HNSCC expressing programmed cell death ligand-1 (PD-L1) with combined positive score (CPS) ≥1.
This trial has two parts.
Part A, is an initial non-randomized Safety Run-In Phase to confirm the safety and tolerability at the selected dose range level of BNT113...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/11/2025
            
            Locations: California Research Institute, Los Angeles, California  +186 locations         
        
        
            Conditions: Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
        
            
        
    409 - 420 of 3905
            