ADVENT Post Approval Study
NCT06431815
Recruiting
The ADVENT Post Approval Study (PAS) is a prospective, global, multicenter, observational study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Mobile Infirmary Medical Center, Mobile, Alabama +33 locations
Conditions: Paroxysmal Atrial Fibrillation
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NEO-BLAST: Neoadjuvant Therapy for Bladder Cancer Followed by Active Surveillance vs Treatment
NCT06537154
Recruiting
Invasive bladder cancer is managed with neoadjuvant therapy followed by bladder removal (cystectomy). Research shows that approximately 40% of patient will have no remaining cancer left in their bladder after completion of the initial systemic treatment, and perhaps could have avoided the surgery. However, currently physicians lack the ability to identify these patients. The investigators believe that by using advanced imaging (MRI), bladder biopsies and novel biomarkers that detect tumor DNA i... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
07/28/2025
Locations: Vancouver Prostate Centre, Vancouver, British Columbia
Conditions: Muscle-Invasive Bladder Carcinoma
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Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
NCT06293365
Recruiting
The purpose of this study is to demonstrate the comparability of ianalumab exposure following the sub-cutaneous (s.c.) administration of one injection of 300 mg/2 mL auto-injector (AI) versus two injections of 150 mg/1 mL pre-filled syringe (PFS), and to evaluate the safety and tolerability of ianalumab following the s.c. administration of both devices in participants with rheumatoid arthritis (RA), Sjögren's disease (SjD), or systemic lupus erythematosus (SLE). A second cohort will be included... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/28/2025
Locations: Pinnacle Research Group Llc, Anniston, Alabama +36 locations
Conditions: Sjögrens Disease, Systemic Lupus Erythematosus, Rheumatoid Arthritis
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ATI-045 Versus Placebo in Patients With Moderate-to-Severe Atopic Dermatitis
NCT07011706
Recruiting
This study evaluates ATI-045 versus placebo in patients with Moderate-to-Severe Atopic Dermatitis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/28/2025
Locations: Aclaris Study Site, Bryant, Arkansas +22 locations
Conditions: Atopic Dermatitis, Atopic, Dermatitis, AD, Eczema
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A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
NCT06979362
Recruiting
This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by chance. The study will last for about 60 weeks.
Gender:
ALL
Ages:
Between 40 years and 84 years
Trial Updated:
07/28/2025
Locations: Univ of Alabama Birmingham, Birmingham, Alabama +88 locations
Conditions: Heart Failure
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Anticoagulation After GI Bleeding Pilot Study and Registry
NCT05290857
Recruiting
PANTHER-GI Pilot Study will assess the feasibility of a full-scale multicentre cohort management study evaluating the safety of a standardized strategy for resuming direct oral anticoagulants (DOACs) after major DOAC-related gastrointestinal (GI) bleeding among patients at moderate to high risk of re-bleeding and thrombosis. A parallel registry will assess whether eligible patients who are not enrolled in the PANTHER-GI Pilot Study are systematically different than enrolled patients and to explo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Alberta Health Services - Peter Lougheed Center Endoscopy Unit, Calgary, Alberta +1 locations
Conditions: GastroIntestinal Bleeding, Anticoagulant-induced Bleeding
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A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
NCT06025578
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
07/28/2025
Locations: The University of Alabama at Birmingham, Birmingham, Alabama +533 locations
Conditions: Progressive Pulmonary Fibrosis
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Early Genomic Testing for Inherited Bleeding Disorders
NCT06736158
Recruiting
The investigators aim to test the introduction of genomic testing early in the diagnostic pathway for inherited bleeding disorders in patients who have not received a diagnosis after first-line testing. The goal of this clinical trial is to test the introduction of genomic testing early in the diagnostic pathway for patients referred to Hematology for a suspected inherited bleeding disorder. The main questions it aims to answer are: 1. Does adding early genomic testing increase the number of p... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/28/2025
Locations: Queen's University/Kingston Health Sciences Centre, Kingston, Ontario +2 locations
Conditions: Bleeding Disorder
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A Study of CC-97540 (BMS-986353), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)
NCT07015983
Recruiting
The purpose of this study is to evaluate the efficacy, safety and drug levels of CC-97540 in participants with active systemic lupus erythematosus (SLE) including lupus nephritis with inadequate response to glucocorticoids and at least 2 immunosuppressants.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
07/28/2025
Locations: Local Institution - 0009, Birmingham, Alabama +70 locations
Conditions: Lupus Erythematosus, Systemic, Lupus Nephritis
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Low Versus Standard Pressure Pneumoperitoneum on Shoulder Tip Pain
NCT06504277
Recruiting
This proposed study is a single-center, double blind, parallel group RCT comparing the use of low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum at the time of benign gynecologic laparoscopic surgery. Patients will be randomized to the control group (standard pressure) or the intervention group (low pressure) and surgeons will be blinded to the study pressure. Data on post-operative recovery and pain scores will be recorded for each patient.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Women's College Hospital, Toronto, Ontario
Conditions: Surgery, Laparoscopic, Laparoscopy, Penumoperitoneum, Post-operative Pain, Post-operative Recovery
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A Study of Barzolvolimab in Patients With Prurigo Nodularis
NCT06366750
Recruiting
The purpose of this study is to assess the efficacy and safety of barzolvolimab in adults with prurigo nodularis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Total Dermatology, Birmingham, Alabama +57 locations
Conditions: Prurigo Nodularis
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Low-Dose Weekly vs High-Dose Cisplatin
NCT03649048
Recruiting
This study is a prospective open-label randomized clinical trial. Following informed consent eligible LASCCHN patients (n=100) planned for CRT will be stratified by tumor p16 status and then randomized in a 1:1 fashion to either concurrent HD cisplatin or concurrent weekly LD cisplatin.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Juravinski Cancer Centre, Hamilton, Ontario +2 locations
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
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