Search
                    All Clinical Trials in Canada
A listing of 3905  clinical trials  actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
            529 - 540 of 3905
        
                
                                    Phase I Trial of Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for Refractory Anorexia Nervosa With Comorbid Obsessive Compulsive Disorder or Major Depressive Disorder
                                
            
            
        Recruiting
                            
            
                The goal of this clinical trial is to evaluate the safety and initial clinical effectiveness of MRI-guided focused ultrasound (MRgFUS) thermal ablation (capsulotomy) in patients with treatment-refractory anorexia nervosa (AN) and comorbid obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). The main questions it aims to answer are:
1. Can MR-guided focused ultrasound capsulotomy be safely delivered through an intact skull in patients with treatment-refractory anorexia nervos...  Read More             
        
        
    Gender:
                ALL
            Ages:
                Between 18 years and 65 years
            Trial Updated:
                08/06/2025
            
            Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario         
        
        
            Conditions: Anorexia Nervosa (DSM-IV Revised Criteria)
        
            
        
    
                
                                    A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 2)
                                
            
            
        Recruiting
                            
            
                This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Center for Dermatology Clinical Research- Site Number : 8400226, Fremont, California  +56 locations         
        
        
            Conditions: Lichen Simplex Chronicus
        
            
        
    
                
                                    A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 1)
                                
            
            
        Recruiting
                            
            
                This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Dermatology Research Associates - Los Angeles- Site Number : 8400004, Los Angeles, California  +56 locations         
        
        
            Conditions: Lichen Simplex Chronicus
        
            
        
    
                
                                    A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
                                
            
            
        Recruiting
                            
            
                Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood...  Read More             
        
        
    Gender:
                ALL
            Ages:
                Between 1 year and 18 years
            Trial Updated:
                08/06/2025
            
            Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona  +164 locations         
        
        
            Conditions: Chronic Kidney Disease, Proteinuria, Children
        
            
        
    
                
                                    Post-operative Changes Study
                                
            
            
        Recruiting
                            
            
                The goal of this observational pilot study is to evaluate the feasibility and acceptability of the protocol to explore the functional post-operative trajectory in a developmentally and neurologically impaired pediatric population.
The main objectives of the study are:
* Objective 1: To evaluate the feasibility and acceptability of the study protocol for children and families living with severe neurological impairment (SNI). To evaluate feasibility the investigators will assess consent rate, pr...  Read More             
        
        
    Gender:
                ALL
            Ages:
                Between 5 years and 18 years
            Trial Updated:
                08/06/2025
            
            Locations: BC Children's Hospital Research Institute, Vancouver, British Columbia         
        
        
            Conditions: Post-operative Functional Decline, Severe Neurological Impairment
        
            
        
    
                
                                    An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study
                                
            
            
        Recruiting
                            
            
                The purpose of this study is:
* To investigate the optimal timing for revaccination after the initial RSVPreF3 OA vaccine dose,
* To evaluate the long-term immune persistence and safety up to 5 consecutive RSV seasons (approximately 60 months) of a single dose of RSVPreF3 OA vaccine,
* To give the opportunity to participants who received only placebo in the RSVOA=ADJ- 006 study, to receive a dose of the RSVPreF3 OA vaccine and collect additional safety information.             
        
        
    Gender:
                ALL
            Ages:
                60 years and above
            Trial Updated:
                08/06/2025
            
            Locations: GSK Investigational Site, Birmingham, Alabama  +251 locations         
        
        
            Conditions: Respiratory Syncytial Virus Infections
        
            
        
    
                
                                    A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
                                
            
            
        Recruiting
                            
            
                In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that made it hard to continue.
The main objective of the study is to learn about the effect litifilimab h...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Pinnacle Research Group, LLC, Anniston, Alabama  +257 locations         
        
        
            Conditions: Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
        
            
        
    
                
                                    A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease
                                
            
            
        Recruiting
                            
            
                This is a study where a new drug, called GSK4771261 is being tested. Neither the study doctors, study staff or participants will be aware of what treatment is being given. Part A is testing the new study treatment on healthy people. This is to see if it's safe, what it does to the body, and how the body's defense system responds to it. Part B is similar, but the study treatment will be given to people who have a kidney disease called autosomal dominant polycystic kidney disease (ADPKD).             
        
        
    Gender:
                ALL
            Ages:
                Between 25 years and 65 years
            Trial Updated:
                08/06/2025
            
            Locations: GSK Investigational Site, Bruxelles, Not set  +13 locations         
        
        
            Conditions: Kidney Disease
        
            
        
    
                
                                    A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada
                                
            
            
        Recruiting
                            
            
                Acute Myeloid Leukemia (AML) is a cancer of the blood and bone marrow and is the most common acute leukemia in adults. This study will evaluate how well venetoclax works to treat AML in adult participants who are ineligible for intensive induction chemotherapy in Canada.
Venetoclax is a drug approved to treat Acute Myeloid Leukemia (AML). All study participants will receive Venetoclax as prescribed by their study doctor in accordance with approved local label. Adult participants with a new diag...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Tom Baker Cancer Centre /ID# 248113, Calgary, Alberta  +19 locations         
        
        
            Conditions: Acute Myeloid Leukemia
        
            
        
    
                
                                    Consolidative Use of Radiotherapy to Block Oligoprogression in Patients With Metastatic Melanoma
                                
            
            
        Recruiting
                            
            
                This open-label, prospective, single-arm Phase II trial explores whether adding stereotactic body radiotherapy (SBRT) or hypofractionated radiotherapy to oligoprogressive lesions can help delay disease progression in patients with metastatic melanoma. Participants may have up to ten extracranial oligoprogressive sites, with no upper limit on the total number of metastatic lesions. The study aims to assess whether targeting these progressing sites with focused radiotherapy can extend progression-...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: University Health Network, Toronto, Ontario         
        
        
            Conditions: Metastatic Melanoma, OligoProgressive Metastatic Disease
        
            
        
    
                
                                    A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors
                                
            
            
        Recruiting
                            
            
                The purpose of this study is to assess the safety and tolerability of BMS-986484 administered alone, in combination with nivolumab in participants with advanced/metastatic solid tumors including non-small cell lung cancer (NSCLC), microsatellite stable (MSS) colorectal carcinoma (CRC), pancreatic ductal adenocarcinoma (PDAC), gastric/gastroesophageal junction adenocarcinoma (G/GEJC), and squamous cell carcinoma of the head and neck (SCCHN).             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: University of Arizona Cancer Center, Tucson, Arizona  +8 locations         
        
        
            Conditions: Advanced Solid Tumors
        
            
        
    
                
                                    Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
                                
            
            
        Recruiting
                            
            
                The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC.             
        
        
    Gender:
                MALE
            Ages:
                Between 18 years and 130 years
            Trial Updated:
                08/06/2025
            
            Locations: Research Site, Chandler, Arizona  +408 locations         
        
        
            Conditions: Metastatic Castration-Sensitive Prostate Cancer
        
            
        
    529 - 540 of 3905
            