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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
Recruiting
This study is a Phase IIIb/IV, multicenter, randomized, two-arm, open-label 100-week study to investigate the efficacy, safety, and durability of intravitreal 6-mg faricimab administered at up to 24-week intervals in patients with neovascular age-related macular degeneration (nAMD) that are treatment-naïve in the study eye.
This study is a Phase IIIb/IV, multicenter, randomized, two-arm, open-label 100-week study to investigate the efficacy, safety, and durability of intravitreal 6-mg faricimab administered at up to 24-week intervals in patients with neovascular age-related macular degeneration (nAMD) that are treatment-naïve in the study eye. Read Less
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/06/2025
Locations: Retinal Diagnostic Center, Campbell, California +48 locations
Retinal Diagnostic Center, Campbell, California
Orange County Retina Medical Group, Santa Ana, California
Florida Retina Institute, Orlando, Florida
Ctr for Retina & Macular Dis, Winter Haven, Florida
Retinal Vitreal Consultants, Chicago, Illinois
University Retina and Macula Associates, PC, Lemont, Illinois
New England Retina Consultants, Springfield, Massachusetts
Sierra Eye Associates, Sparks, Nevada
Charles Retina Institute, Germantown, Tennessee
Retina Consultants of Texas, Schertz, Texas
Strathfield Retina Clinic, Strathfield, New South Wales
Sydney Eye Hospital, Sydney, New South Wales
Adelaide Eye and Retina Centre, Adelaide, South Australia
Centre For Eye Research Australia, East Melbourne, Victoria
Retina Specialists Victoria, Rowville, Victoria
The Lions Eye Institute, Nedlands, Western Australia
St. Joseph's Health Care, London, Ontario
Retina Institute of Ottawa, Ottawa, Ontario
Toronto Retina Institute, Toronto, Ontario
Toronto Western Hospital, Toronto, Ontario
Peking University People's Hospital, Beijing, Not set
West China Hospital of Sichuan University, Chengdu City, Not set
Sichuan Provincial People's Hospital, Chengdu, Not set
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou City, Not set
Eye and ENT hospital, Fudan University, Shanghai, Not set
Tongji Hosp, Tongji Med. Col, Huazhong Univ. of Sci. & Tech, Wuhan, Not set
Augenzentrum Prof. Koch GmbH, Frankfurt, Not set
Medizinische Hochschule Hannover, Klinik für Augenheilkunde, Hannover, Not set
Augenzentrum am St Franziskus-Hospital, Münster, Not set
Universitätsklinikum Ulm, Augenklinik und Poliklinik, Ulm, Not set
Azienda ospedaliero - universitaria Sant'Andrea;UOC Oculistica, Roma, Lazio
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Lombardia
Ospedale San Giuseppe, Milano, Lombardia
Azienda Ospedaliero Universitaria Ospedali Riuniti, Torrette - Ancona, Marche
Pusan National University Hospital, Busan, Not set
Yeungnam Univ. Hospital, Daegu, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Singapore Eye Research Institute, Singapore, Not set
Tan Tock Seng Hospital, Singapore, Not set
Hospital General de Catalunya, Sant Cugat De Valles, Barcelona
Oftalvist, Burjassot, Valencia(España), Valencia
Clinica Baviera, Madrid, Not set
Hospital Universitario Virgen del Rocio - Servicio de Oftalmologia;Servicio de Oftalmologia, Sevilla, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
National Taiwan University Hospital, Zhongzheng Dist., Not set
Conditions: Neovascular Age-related Macular Degeneration (nAMD)
A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 2)
Recruiting
This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6.
This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Center for Dermatology Clinical Research- Site Number : 8400226, Fremont, California +56 locations
Center for Dermatology Clinical Research- Site Number : 8400226, Fremont, California
Moore Clinical Research - Brandon- Site Number : 8400208, Brandon, Florida
Southern Indiana Clinical Research Center- Site Number : 8400230, Columbus, Indiana
Clinical Research of Philadelphia- Site Number : 8400215, Philadelphia, Pennsylvania
Austin Institute for Clinical Research - Pflugerville- Site Number : 8400203, Pflugerville, Texas
Progressive Clinical Research - San Antonio- Site Number : 8400206, San Antonio, Texas
Investigational Site Number : 0320204, Berazategui, Buenos Aires
Investigational Site Number : 0320202, San Miguel de Tucumán, Tucumán
Investigational Site Number : 0320201, Buenos Aires, Not set
Investigational Site Number : 0320203, Córdoba, Not set
Investigational Site Number : 0560202, Alken, Not set
Investigational Site Number : 1240210, Calgary, Alberta
Investigational Site Number : 1240207, Edmonton, Alberta
Investigational Site Number : 1240201, Surrey, British Columbia
Investigational Site Number : 1240205, London, Ontario
Investigational Site Number : 1240208, Markham, Ontario
Investigational Site Number : 1240209, Toronto, Ontario
Investigational Site Number : 1240203, Verdun, Quebec
Investigational Site Number : 1520202, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520201, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1560204, Chongqing, Not set
Investigational Site Number : 1560206, Guangzhou, Not set
Investigational Site Number : 1560201, Guangzhou, Not set
Investigational Site Number : 1560202, Guangzhou, Not set
Investigational Site Number : 1560203, Wuhan, Not set
Investigational Site Number : 2030201, Prague, Not set
Investigational Site Number : 2030202, Prague, Not set
Investigational Site Number : 2030203, Prague, Not set
Investigational Site Number : 2760201, Berlin, Not set
Investigational Site Number : 2760202, Frankfurt, Not set
Investigational Site Number : 2760205, Hamburg, Not set
Investigational Site Number : 2760203, Kiel, Not set
Investigational Site Number : 3000203, Athens, Not set
Investigational Site Number : 3000201, Athens, Not set
Investigational Site Number : 3000202, Ioannina, Not set
Investigational Site Number : 3480202, Orosháza, Not set
Investigational Site Number : 3480201, Pecs, Not set
Investigational Site Number : 3800201, Naples, Napoli
Investigational Site Number : 3800202, Rome, Roma
Investigational Site Number : 4100202, Ansan-si, Gyeonggi-do
Investigational Site Number : 4100203, Bupyeong-gu, Incheon-gwangyeoksi
Investigational Site Number : 4100201, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100204, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4840201, Guadalajara, Jalisco
Investigational Site Number : 4840202, Monterrey, Nuevo León
Investigational Site Number : 4840203, Mérida, Yucatán
Investigational Site Number : 7240203, Pozuelo de Alarcón, Madrid
Investigational Site Number : 7240204, Alicante, Not set
Investigational Site Number : 7240202, Madrid, Not set
Investigational Site Number : 7240201, Madrid, Not set
Investigational Site Number : 1580203, Hsinchu, Not set
Investigational Site Number : 1580202, Taichung, Not set
Investigational Site Number : 1580201, Taoyuan City, Not set
Investigational Site Number : 7920202, Gaziantep, Not set
Investigational Site Number : 7920201, Istanbul, Not set
Investigational Site Number : 7920203, Istanbul, Not set
Investigational Site Number : 8260201, Southampton, Hampshire
Conditions: Lichen Simplex Chronicus
Met Non Small Cell Cancer Registry (MOMENT)
Recruiting
The purpose of this multi-national disease registry is to collect prospectively (with longitudinal follow-up) high-quality, standardized, and contemporaneous data to capture changes in the non-small cell lung cancer (NSCLC) treatment landscape and outcomes over time.
The registry will capture data on participants; demographic, clinical characteristics (including biomarker data), treatment patterns, and effectiveness and safety outcomes for advanced NSCLC with mesenchymal-epithelial transition e... Read More
The purpose of this multi-national disease registry is to collect prospectively (with longitudinal follow-up) high-quality, standardized, and contemporaneous data to capture changes in the non-small cell lung cancer (NSCLC) treatment landscape and outcomes over time.
The registry will capture data on participants; demographic, clinical characteristics (including biomarker data), treatment patterns, and effectiveness and safety outcomes for advanced NSCLC with mesenchymal-epithelial transition exon 14 (METex14) participants treated with systemic therapy. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
08/06/2025
Locations: Holy Cross Health, Fort Lauderdale, Florida +63 locations
Holy Cross Health, Fort Lauderdale, Florida
The Ohio State University Wexner Medical Center, Columbus, Ohio
Vanderbilt University Medical Center, Nashville, Tennessee
Klinikum Klagenfurt Am Woerthersee, Klagenfurt am Wörthersee, Not set
Klinik Floridsdorf, Wien, Not set
AZ Delta, Roeselare, Not set
AZ Nikolaas, Sint-Niklaas, Not set
Ottawa Hospital General Campus, Ottawa, Not set
Princess Margaret Cancer Centre, Toronto, Not set
FN Olomouc, Olomouc, Not set
University Hospital Na Bulovce, Praha 8, Not set
University Hospital of Tampere, Tampere, Not set
Turun Yliopistollinen Keskussairaala, Turku, Not set
Centre Hospitalier de Cholet, Cholet, Not set
CHRU Lille, Lille cedex, Not set
Hôpital du Scorff, Lorient, Not set
Centre Leon Berard, Lyon Cedex 08, Not set
Institut Curie - Centre de Lutte Contre le Cancer (CLCC), Paris Cedex 05, Not set
Hospital Tenon & University Paris 6, Paris, Not set
CHU de Toulouse Hopital Larrey, Toulouse, Not set
Klinikum Chemnitz GmbH, Chemnitz, Not set
KKH Grosshansdorf GmbH, Grosshansdorf, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Klinik Löwenstein GmbH, Löwenstein, Not set
Haemek Medical Center, Afula, Not set
Assuta Ashdod Medical Center, Ashdod, Not set
Bnei-Zion Medical Center, Haifa, Not set
Carmel Medical Center, Haifa, Not set
Rambam Medical Center - PPDS, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Rabin Medical Center Oncology Beilinson Campus, Petach Tikva, Not set
Chaim Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
Istituto Europeo di Oncologia, Milano, Not set
Istituto Nazionale Dei Tumori, Milano, Not set
AOU dell'Università degli Studi della Campania Luigi Vanvitelli, Napoli, Not set
I.F.O. Istituto Nazionale Tumori Regina Elena IRCCS, Rome, Not set
Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Torino, Not set
Ospedale di Circolo, Varese, Not set
VU Medisch Centrum, Amsterdam, Not set
Universitair Medisch Centrum Groningen - Department of Medical Oncology, Groningen, Not set
Leiden University Medical Center, Leiden, Not set
Centro Hospitalar de Lisboa Norte, EPE - Hospital de Santa Maria, Lisboa, Not set
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto Covo, Not set
Centro Hospitalar do Porto E.P.E. Hospital de Santo António, Porto, Not set
Clinica Tres Torres, Barcelona, Not set
Institut Universitari Dexeus-Quiron - Servei d oncologia medica - Institut Oncologic Dr. Rosell, Barcelona, Not set
Complejo Hospitalario Universitario Insular-Materno Infantil, las Palmas de Gran Canaria, Not set
Centro Integral Oncologico Clara Campa, Madrid, Not set
Centro Oncologico MD Anderson, Madrid, Not set
Hospital Regional Universitario de Malaga - Hospital General, Malaga, Not set
Hospidal Universitario Ntra. Sra. De Valme, Sevilla, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Universitetssjukhuset i Linköping, Linköping, Not set
Bedford General Hospital, Bedford, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
Royal Bournemouth Hospital, Bournemouth, Not set
The Royal Marsden Hospital, Chelsea, Not set
Royal Surrey County Hospital, Guildford, Not set
Northwick Park Hospital, Harrow, Not set
Clatterbridge Cancer Centre - Liverpool, Liverpool, Not set
Charing Cross Hospital, London, Not set
Preston Hospital, Preston, Not set
Conditions: Cancer
Consolidative Use of Radiotherapy to Block Oligoprogression in Patients With Metastatic Melanoma
Recruiting
This open-label, prospective, single-arm Phase II trial explores whether adding stereotactic body radiotherapy (SBRT) or hypofractionated radiotherapy to oligoprogressive lesions can help delay disease progression in patients with metastatic melanoma. Participants may have up to ten extracranial oligoprogressive sites, with no upper limit on the total number of metastatic lesions. The study aims to assess whether targeting these progressing sites with focused radiotherapy can extend progression-... Read More
This open-label, prospective, single-arm Phase II trial explores whether adding stereotactic body radiotherapy (SBRT) or hypofractionated radiotherapy to oligoprogressive lesions can help delay disease progression in patients with metastatic melanoma. Participants may have up to ten extracranial oligoprogressive sites, with no upper limit on the total number of metastatic lesions. The study aims to assess whether targeting these progressing sites with focused radiotherapy can extend progression-free survival in this patient population. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: University Health Network, Toronto, Ontario
University Health Network, Toronto, Ontario
Conditions: Metastatic Melanoma, OligoProgressive Metastatic Disease
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
Recruiting
This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML).
This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML). Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/06/2025
Locations: City of Hope Phoenix, Goodyear, Arizona +267 locations
City of Hope Phoenix, Goodyear, Arizona
Mayo Clinic - Phoenix, Phoenix, Arizona
University of Arizona Cancer Center, Tucson, Arizona
Ucsf - School of Medicine, San Francisco, California
Stanford University School of Medicine- Parent, Stanford, California
Colorado Blood Cancer Institute, Denver, Colorado
Yale University, New Haven, Connecticut
Mayo Clinic Hospital, Jacksonville, Florida
Florida Hospital Cancer Institute - Kissimmee, Kissimmee, Florida
Tampa General Hospital, Tampa, Florida
Moffit Cancer Center, Tampa, Florida
Augusta University, Augusta, Georgia
University of Illinois Hospital & Health Sciences System, Chicago, Illinois
The University of Chicago Medical Center, Chicago, Illinois
University of Kentucky, Lexington, Kentucky
Ochsner Medical Center - New Orleans, New Orleans, Louisiana
Johns Hopkins Hospital, Baltimore, Maryland
University of Michigan Comprehensive Cancer Center Michigan Medicine, Ann Arbor, Michigan
Henry Ford Hospital, Detroit, Michigan
University of Minnesota Medical School - Twin Cities Campus, Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
Washington University, Saint Louis, Missouri
Hackensack University Medical Center, Hackensack, New Jersey
Thomas Jefferson Univ Hosp, Haddonfield, New Jersey
Roswell Park Comprehensive Cancer Center, Buffalo, New York
Memorial Sloan Kettering Cancer Center - Main, New York, New York
Upstate University Hospital, Syracuse, New York
University of North Carolina Hospitals, Chapel Hill, North Carolina
Duke Cancer Institute - Sarcoma Research, Durham, North Carolina
University of Cincinnati, Cincinnati, Ohio
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio
The James Cancer Hospital and Solove Research Institute, Columbus, Ohio
Ohio Health Marion Area Physicians, Columbus, Ohio
Oregon Health & Science University (Ohsu), Portland, Oregon
University of Pennsylvania, Philadelphia, Pennsylvania
Upmc Hillman Cancer Center, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Tristar Bone Marrow Transplant, Nashville, Tennessee
South Austin Medical Center, Austin, Texas
Houston Methodist Hospital, Houston, Texas
The University of Texas Md Anderson Cancer Center, Houston, Texas
Uva Health System, Charlottesville, Virginia
Virginia Commonwealth University (Vcu) Massey Cancer Center, Richmond, Virginia
Medical College of Wisconsin, Milwaukee, Wisconsin
Royal Adelaide Hospital, Adelaide, Not set
Flinders Medical Centre (Fmc), Bedford Park, Not set
Box Hill Hospital, Box Hill, Not set
Concord Repatriation General Hospital, Concord, Not set
St Vincent'S Hospital Melbourne, Darlinghurst, Not set
Townsville University Hospital, Douglas, Not set
Liverpool Hospital, Liverpool, Not set
The Alfred Hospital, Melbourne, Not set
Fiona Stanley Hospital, Murdoch, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Ordensklinikum Linz Gmbh - Elisabethinen, Linz, Not set
LKH - Universitätsklinikum der PMU Salzburg, Salzburg, Not set
Hanusch Krankenhaus Der Wgkk Wien, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
ZNA, Antwerpen, Not set
Az Sint-Jan, Brugge, Not set
Uz Leuven, Leuven, Not set
Chu of Liège, Liege, Not set
AZ DELTA, Roeselare, Not set
Unesp - Faculdade de Medicina Da Universidade Estadual Paulista - Campus Botucatu, Botucatu, Not set
Centro de Hematologia E Hemoterapia - Hemocentro de Campinas - Unicamp, Campinas, Not set
Centro de Hematologia e Hemoterapia - Hemocentro de Campinas - UNICAMP, Campinas, Not set
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba, Not set
Hospital Erasto Gaertner - Liga Paranaense de Combate Ao Că'Ncer, Curitiba, Not set
Cepon - Centro De Pesquisas Oncolagicas de Santa Catarina, Florianopolis, Not set
HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará, Fortaleza, Not set
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás, Goiania, Not set
Hc-Ufg - Hospital Das Clă Nicas Da Universidade Federal de Goiă S, Goiania, Not set
Fundacao Doutor Amaral Carvalho, Jau, Not set
Fundaã§Ã£O Doutor Amaral Carvalho, Jaú, Not set
Hospital de Clínicas de Passo Fundo, Passo Fundo, Not set
Hospital de Clă Nicas de Passo Fundo, Passo Fundo, Not set
Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Not set
Hospital de Clă Nicas de Porto Alegre, Porto Alegre, Not set
Hospital Ernesto Dornelles, Porto Alegre, Not set
INCA - Instituto Nacional de Cancer, Rio de Janeiro, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, Sao Jose Rio Preto, Not set
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, Sao Paulo, Not set
Hospital Beneficencia Portuguesa da Sao Paulo, Sao Paulo, Not set
Hospital Nove de Julho, Sao Paulo, Not set
Icesp - Instituto Do Câncer Do Estado de São Paulo Octavio Frias de Oliveira, SĂŁo Paulo, Not set
Umhat 'Dr. Georgi Stranski', Ead, Pleven, Not set
Umhat 'Sv. Georgi', Ead, Plovdiv, Not set
Umhat  Sv. Ivan Rilskiâ , Ead, Sofia, Not set
Military Medical Academy - Mhat - Sofia, Sofia, Not set
'Shathd' Ead Sofia, Sofia, Not set
Umhat Prof. Dr. Stoyan Kirkovich Ad, Stara Zagora, Not set
London Health Sciences Centre, London, Not set
The Ottawa Hospital - General Campus, Ottawa, Not set
Saskatoon Cancer Centre, Saskatoon, Not set
Princess Margaret Cancer Center, Toronto, Not set
Peking University First Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
Peking Union Medical College Hospital, Beijing, Not set
The First Hospital of Jilin University, Changchun, Not set
Xiangya Hospital, Central South University, Changsha, Not set
The Second Xiangya Hospital of Central South University, Changsha, Not set
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Not set
Sun Yat-Sen University, Cancer Center, Guangzhou, Not set
Guangdong Provincial People'S Hospital, Guangzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
Qilu Hospital of Shandong University, Jinan, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Zhong Da Hospital, Southeast University, Nanjing, Not set
Affiliated Hospital of Nantong University, Nantong, Not set
The Affiliated Hospital of Qingdao University, Qingdao, Not set
Shanghai Tongren Hospital, Shanghai, Not set
Shengjing Hospital of China Medical University, Shengyang, Not set
Shenzhen Second People'S Hospital, Shenzhen, Not set
The First Affiliated Hospital of Soochow University, Suzhou, Not set
Institute of Hematology and Hospital of Blood Disease, Tianjin, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
Wuxi People'S Hospital, Wuxi, Not set
The First Affiliated Hospital of Xiâ An Jiaotong University, Xi'an, Not set
Yantai Yuhuangding Hospital, Yantai, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Clinical Hospital Centre Rijeka, Rijeka, Not set
Clinical Hospital Centar Zagreb, Zagreb, Not set
Clinical Hospital Dubrava, Zagreb, Not set
Fakultni Nemocnice Brno, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni Nemocnice Ostrava, Ostrava - Poruba, Not set
Fakultni Nemocnice Plzen, Plzen, Not set
Fakultni Nemocnice Kralovske Vinohrady, Praha 10, Not set
Ustav Hematologie A Krevni Transfuze, Praha 2, Not set
Chu Angers - Hă"Pital Hă"Tel Dieu, Angers, Not set
Chu de Caen, Caen, Not set
Chu de Grenoble - Hospital Albert Michallon, La Tronche, Not set
Centre Hospitalier de Versailles, Le Chesnay Cedex, Not set
Hopital Claude Huriez - Chru Lille, Lille cedex, Not set
Centre Léon Bérard, Lyon, Not set
Hopital de La Conception - Aphm, Marseille Cedex 05, Not set
Chu de Nantes - Hotel Dieu, Nantes cedex 1, Not set
CHU Nice - Hôpital de l'Archet 1, Nice, Not set
Hospital Saint-Louis, Paris cedex 10, Not set
Chu de Bordeaux - Hă"Pital Haut-Lă Vă Que, Pessac cedex, Not set
Centre Hospitalier Lyon Sud, Pierre BĂŠnite, Not set
Chu Rennes - Hopital Pontchaillou, Rennes cedex 09, Not set
Chu Amiens - Hopital Sud, Salouel, Not set
Institut de Cancă Rologie de Strasbourg Europe - Icans, Strasbourg, Not set
Institut Universitaire Du Cancer de Toulouse- Iuct-O, Toulouse, Not set
Klinikum Aschaffenburg-Alzenau, Alzenau, Not set
Staedtisches Klinikum Braunschweig Ggmbh, Braunschweig, Not set
Universitaetsklinikum Carl Gustav Carus Tu Dresden, Dresden, Not set
Universitaetsklinikum Essen, Essen, Not set
Krh Klinikum Siloah, Hannover, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Schleswig-Holstein, Kiel, Not set
Universită"Tsklinikum Leipzig Klinik Fă R Hă"Matologie Internistische Onkologie Hă"Mostaseol, Leipzig, Not set
Universitaetsklinikum Muenster, Münster, Not set
The University of Hong Kong, Hong kong, Not set
The Chinese University of Hong Kong (Cuhk), Shatin, Not set
Semmelweis Egyetem, Budapest, Not set
Debreceni Egyetem, Debrecen, Not set
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz, Gyor, Not set
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged, Not set
Azienda Ospedaliero Universitaria Consorziale Policlinico Di Bari, Bari, Not set
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili), Brescia, Not set
Irccs Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori 'Dino Amadori' - Irst, Meldola, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda), Milano, Not set
Ospedale Maggiore Di Novara, Novara, Not set
Azienda Ospedaliera Vincenzo Cervello, Palermo, Not set
Fondazione Policlinico Universitario Agostino Gemelli Irccs, Roma, Not set
Azienda Ospedaliera Universitaria Policlinico Tor Vergata, Rome, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Irccs Ospedale Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Not set
Azienda Ospedaliero-Universitaria Cittă Della Salute E Della Scienza Di Torino, Torino, Not set
Ospedale Mauriziano Umberto I, Torino, Not set
Asst Dei Sette Laghi Ospedale Di Circolo E Fondazione Macchi Varese, Varese, Not set
Akita University Hospital, Akita, Not set
Aomori Prefetural Central Hospital, Aomori, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo-ku, Not set
Chiba Aoba Municipal Hospital, Chiba-shi, Not set
Kyushu University Hospital, Fukuoka, Not set
Chugoku Central Hospital, Fukuyama, Not set
Gifu Municipal Hospital, Gifu, Not set
Hamamatsu University School of Medicine, University Hospital, Hamamatsu, Not set
Tesshokai Kameda General Hospital, Kamogawa-shi, Not set
Kanazawa University Hospital, Kanazawa, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set
Saiseikai Maebashi Hospital, Maebashi, Not set
Ehime Prefectural Central Hospital, Matsuyama, Not set
Nagoya University Hospital, Nagoya, Not set
Japan RED CROSS OSAKA HOSPITAL, Osakar, Not set
Hokkaido University Hospital, Sapporo, Not set
Sapporo Hokuyu Hospital, Sapporo, Not set
Tenri Hospital, Tenri, Not set
Inje University Haeundae Paik Hospital, Busan, Not set
Pusan National University Hospital, Busan, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Yeungnam University Hospital, Daegu, Not set
Daegu Catholic University Medical Center, Daegu, Not set
Chonnam National University Hwasun Hospital, Hwasun-gun, Not set
Gachon University Gil Medical Center, Incheon, Not set
Jeonbuk National University Hospital, Jeonju-si, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary'S Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Ajou University Hospital, Suwon, Not set
Ulsan University Hospital, Ulsan, Not set
Haukeland Universitetssykehus, Bergen, Not set
Oslo University Hospital, Oslo, Not set
University Hospital of North Norway, Tromsø, Not set
Klinika Hematoonkologii I Transplantacji Szpiku, Lublin, Not set
Spzoz Msw Zwarmiĺ Sko-Mazurskimcen.Onko.Wolsztynie, Olsztyn, Not set
Wojewodzki Szpital Zespolony Im. L. Rydygiera W Toruniu, Torun, Not set
Instytut Hematologii I Transfuzjologii, Warszawa, Not set
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisboa, Not set
Instituto Portugues De Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Spitalul Clinic Colentina, Bucuresti, Not set
Institutul Clinic Fundeni, Bucuresti, Not set
Spitalul Clinic Coltea, Bucuresti, Not set
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, Cluj-Napoca, Not set
Spitalul Clinic Municipal Filantropia Craiova, Craiova, Not set
Military Medical Academy, Belgrade, Not set
University Clinical Center of Serbia, Belgrade, Not set
University Clinical Center Nis, Nis, Not set
National University Hospital, Singapore, Not set
Curie Oncology Pte Ltd, Singapore, Not set
Complejo Hospitalario Universitario de Albacete, Albacete, Not set
Hospital de La Santa Creu I Sant Pau, Barcelona, Not set
Hospital Universitario De Burgos, Burgos, Not set
Hospital San Pedro de Alcantara, Caceres, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas, Not set
Clinica Universidad de Navarra, Madrid, Not set
Md Anderson Cancer Centre, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Not set
Hospital Regional Universitario de Malaga, Malaga, Not set
Hospital General Universitario Morales Meseguer, Murcia, Not set
Hospital Universitari Son Espases, Palma de Mallorca, Not set
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Not set
Hospital Universitario Virgen Del Rocio, Seville, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Hospital Universitario Dr. Peset, Valencia, Not set
Hospital Universitari I Politecnic La Fe, Valencia, Not set
Sahlgrenska Universitetssjukhuset, Gasteborg, Not set
Skă Nes Universitetssjukhus, Lund, Lund, Not set
Akademiska Sjukhuset, Uppsala, Not set
Inselspital - Universitaetsspital Bern, Bern, Not set
Luzerner Kantonsspital - Luzern, Lazern 16, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
National Cheng Kung University Hospitalx, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital, Taoyuan County, Not set
King'S College Hospital, London, Not set
Hammersmith Hospital, London, Not set
Maidstone Hospital, Maidstone, Not set
Manchester Royal Infirmary, Manchester, Not set
Churchill Hospital, Oxford, Not set
Torbay Hospital, Torquay, Not set
Conditions: Leukemia
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Recruiting
This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810), called "study drugs". The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the combination of fianlimab and cemiplimab is in treating melanoma, in comparison with the combination of two medications, relatlimab and nivolumab, commercialized under the bra... Read More
This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810), called "study drugs". The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the combination of fianlimab and cemiplimab is in treating melanoma, in comparison with the combination of two medications, relatlimab and nivolumab, commercialized under the brand name Opdualag™ and approved for the treatment of melanoma in adults and children.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drugs.
* How much study drug is in the blood at different times.
* Whether the body makes antibodies against the study drugs (which could make the drug less effective or could lead to side effects) Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Ironwood Cancer & Research Centers, Chandler, Arizona +98 locations
Ironwood Cancer & Research Centers, Chandler, Arizona
Banner MD Anderson Cancer Center, Gilbert, Arizona
Arizona Oncology Associates, Tucson, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Providence Medical Foundation, Fullerton, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
University of California Los Angeles, Los Angeles, California
St. Joseph Hospital Orange, Orange, California
Eisenhower Medical Center, Rancho Mirage, California
Sutter Health, Sacramento, California
University of California San Francisco (UCSF), San Francisco, California
Sansum Clinic, Santa Barbara, California
St John's Cancer Institute, Santa Monica, California
Rocky Mountain Regional VA Medical Center, Aurora, Colorado
University of Colorado Cancer Center, Aurora, Colorado
The Melanoma And Skin Cancer Institute, Englewood, Colorado
UCHealth, Fort Collins, Colorado
Yale Cancer Center, New Haven, Connecticut
Clermont Oncology Center, Clermont, Florida
Mayo Clinic Florida, Jacksonville, Florida
Cancer Specialist of North Florida, Jacksonville, Florida
Boca Raton Clinical Research (BRCR) Global, Tamarac, Florida
H. Lee Moffitt Cancer Center, Tampa, Florida
University Cancer & Blood Center, Athens, Georgia
John B. Amos Cancer Center, Columbus, Georgia
Beacon Clinic, Coeur d'Alene, Idaho
Hope and Healing Cancer Services, Hinsdale, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare, Peoria, Illinois
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana
The University of Kansas Cancer Center, Westwood, Kansas
Markey Cancer Center Clinical Research Organization, Lexington, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Maryland Oncology Hematology, P.A., Columbia, Maryland
Karmanos Cancer Institute, Detroit, Michigan
Minnesota Oncology Hematology, P.A, Fridley, Minnesota
Allina Health Cancer Institute, Minneapolis, Minnesota
VA St. Louis Healthcare System, Saint Louis, Missouri
Washington University, Saint Louis, Missouri
Mercy South, Saint Louis, Missouri
St. Vincent Healthcare, Billings, Montana
Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha, Nebraska
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
John Theurer Cancer Center, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
The Valley Hospital Inc., Paramus, New Jersey
New York Oncology Hematology, Albany, New York
Messino Cancer Center, Asheville, North Carolina
Levine Cancer Institute, Charlotte, North Carolina
Novant Health Cancer Institute, Charlotte, North Carolina
Novant Health Weisiger Cancer Institute - Charlotte, Charlotte, North Carolina
Duke Health System, Durham, North Carolina
Novant Health Zimmer Cancer Institute - Wilmington, Wilmington, North Carolina
Oncology Hematology Care Clinical Trials, Cincinnati, Ohio
Seidman Cancer Center, Cleveland, Ohio
Oklahoma Cancer Specialists and Research Institute, LLC, Tulsa, Oklahoma
Oncology Associates of Oregon PC, Eugene, Oregon
Kaiser Foundation Hospitals, Portland, Oregon
St. Luke's University Health Network, Easton, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania
Lifespan Cancer Institute, Providence, Rhode Island
Saint Francis Cancer Center, Greenville, South Carolina
Tennessee Oncology - Chattanooga, Chattanooga, Tennessee
University of Tennessee Medical Center, Knoxville, Tennessee
Sarah Cannon Research Institute (SCRI) Oncology Partners, Nashville, Tennessee
Tennessee Oncology, Nashville, Tennessee
Texas Oncology - Austin Midtown, Midtown Medical Center I, Austin, Texas
Texas Oncology - Austin Central, Central Austin Cancer Center, Austin, Texas
Texas Oncology - Bedford, Bedford, Texas
Texas Oncology - Medical City, Dallas, Texas
Texas Oncology, Dallas, Texas
Center For Disease And Blood Disorder, Fort Worth, Texas
Texas Oncology - Fort Worth, Fort Worth, Texas
Texas Oncology - Grapevine, Grapevine, Texas
Texas Oncology - Harlingen, Medical Arts Pavillion, Harlingen, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
Texas Oncology - Longview, Longview, Texas
Joe Arrington Cancer Research & Treatment Center, Lubbock, Texas
Texas Oncology - McAllen, McAllen, Texas
Texas Oncology-Palestine Cancer Center, Palestine, Texas
The University of Texas Health Science Center at Tyler D/B/A UT Health East Texas HOPE Cancer Center, Tyler, Texas
Texas Oncology-Tyler, Northeast Texas Cancer Institute, Tyler, Texas
Texas Oncology - Weslaco, Knapp Medical Plaza, Weslaco, Texas
University of Utah Huntsman Cancer Institute, Salt Lake City, Utah
University of Virginia, Charlottesville, Virginia
Virginia Cancer Specialists, PC, Fairfax, Virginia
Virginia Oncology Associates, Norfolk, Virginia
Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia
Oncology & Hematology Associates of Southwest Virginia, Inc., Roanoke, Virginia
Swedish Cancer Institute - Edmonds Campus, Edmonds, Washington
Swedish Cancer Institute - Issaquah Campus, Issaquah, Washington
Swedish Cancer Institute, Seattle, Washington
West Virginia University, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
London Regional Cancer Centre, London, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Centre Hospitalier Universitaire de Quebec (CHUQ) - Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Conditions: Melanoma
Phase I Trial of Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for Refractory Anorexia Nervosa With Comorbid Obsessive Compulsive Disorder or Major Depressive Disorder
Recruiting
The goal of this clinical trial is to evaluate the safety and initial clinical effectiveness of MRI-guided focused ultrasound (MRgFUS) thermal ablation (capsulotomy) in patients with treatment-refractory anorexia nervosa (AN) and comorbid obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). The main questions it aims to answer are:
1. Can MR-guided focused ultrasound capsulotomy be safely delivered through an intact skull in patients with treatment-refractory anorexia nervos... Read More
The goal of this clinical trial is to evaluate the safety and initial clinical effectiveness of MRI-guided focused ultrasound (MRgFUS) thermal ablation (capsulotomy) in patients with treatment-refractory anorexia nervosa (AN) and comorbid obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). The main questions it aims to answer are:
1. Can MR-guided focused ultrasound capsulotomy be safely delivered through an intact skull in patients with treatment-refractory anorexia nervosa and comorbid OCD and/or MDD, with a safety and side-effect profile comparable to traditional radiofrequency neurosurgical approaches?
2. Does MRgFUS capsulotomy produce clinical outcomes comparable to open surgical ablative procedures-specifically, improvements in anxiety, mood, quality of life, anorexia nervosa psychopathology, habit formation, and weight-in patients with treatment-refractory anorexia nervosa?
Participants will:
1. Undergo baseline imaging and clinical assessments
2. Receive a single MRgFUS capsulotomy targeting the ALIC
3. Be monitored for 24 months post-treatment to assess adverse events, quality of life, and symptom changes using standardized clinical and neuropsychiatric measures Read Less
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/06/2025
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Anorexia Nervosa (DSM-IV Revised Criteria)
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
Recruiting
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood... Read More
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can help improve kidney function by reducing the activity of the renin-angiotensin-aldosterone system (RAAS). The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can impair the ability of the kidneys to work properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system.
The study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB.
So, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function.
The main purpose of this study is to learn how safe the treatment is when used of finerenone in addition to an ACEI or ARB in long-term.
To see how safe the treatment is, the study team will collect information on medical problems which are also known as "treatment emergent adverse events" (TEAEs). And they will also collect levels of an electrolyte called potassium in the blood by taking blood samples, and measure blood pressure during the study.
The secondary purpose of this study is to learn how well long-term use of finerenone can reduce the amount of protein in the participants' urine and benefit kidney function when taken with standard of care.
To see how the treatment works, the study team will collect participants' urine samples to assess urinary albumin-to-creatinine ratio (UACR) and urinary protein-to-creatinine ratio (UPCR), which are important assessments for calculating the level of protein in the urine. Researchers will also collect blood samples to analyze serum creatinine and calculate estimated glomerular filtration rate (eGFR). A significant decline in eGFR indicates worsening kidney function.
The study will include participants who had previously participated in FIONA study (NCT05196035). The participants will be aged from 1 year up to 18 years.
The participants will be in the study for approximately 19 months. They will take study treatment for up to 18 months and will be follow up for 1 month. During this period, at least 12 visits are planned for patients who newly start finerenone, and at least 8 visits for patients who already received finerenone.
In the visit, the study team will:
* have their blood pressure, heart rate, temperature, height and weight measured
* have blood and urine samples taken
* have physical examinations
* have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart)
* answer questions about their medication and whether they have any adverse events, or have their parents or guardian's answer
* answer questions about how they are feeling, or have their parents or guardian's answer
* answer question about how they like the study medication, or have their parents or guardian's answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.
The doctors will check the participants' health about 30 days after the participants take their last treatment. Read Less
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
08/06/2025
Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona +164 locations
Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona
Cedars-Sinai Samuel Oschin Cancer Center, Los Angeles, California
Lucille Packard Children's Hospital Stanford - Pediatric Nephrology, Palo Alto, California
Rady Children's Hospital San Diego - Cardiology, San Diego, California
Children's National Medical Center - Nephrology, Washington, District of Columbia
Memorial Transplant Institute - Pediatric Nephrology, Hollywood, Florida
Emory University Hospital/Children's Healthcare of Atlanta - Nephrology, Atlanta, Georgia
University of Iowa Health Care Medical Center - Nephrology, Iowa City, Iowa
The Charlotte R. Bloomberg Children's Center Building - Nephrology, Baltimore, Maryland
Boston Children's Hospital - Main Campus - Nephrology, Boston, Massachusetts
Children's Mercy Hospital Kansas City - Nephrology, Kansas City, Missouri
Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension, Cincinnati, Ohio
Cleveland Clinic | Pediatric Nephrology, Cleveland, Ohio
OHSU Doernbecher Children's Hospital - Neurology, Portland, Oregon
Children's Hospital of Philadelphia - Nephrology, Philadelphia, Pennsylvania
University Hospital - San Antonio - Pediatric Nephrology, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
Seattle Children's Hospital - Nephrology, Seattle, Washington
Hospital de Niños Sor María Ludovica, La Plata, Buenos Aires
Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department, Ciudad Autonoma de Buenos Aire, Ciudad Auton. De Buenos Aires
Centro de Rehabilitacion Cardiovascular | San Luis, Argentina, San Luis, Provincia De San Luis
Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina, Santa Fe, Provincia De Santa Fe
Hospital Italiano de Buenos Aires, Buenos Aires, Not set
Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Not set
Hospital General de Ninos Pedro de Elizalde | Nephrology Department, Ciudad Autonoma de Buenos Aire, Not set
Many Locations, Multiple Locations, Not set
Queensland Children's Hospital, South Brisbane, Queensland
Monash Children's Hospital, Clayton, Victoria
Royal Children's Hospital Melbourne, Parkville, Victoria
Kepler Universitätsklinikum Campus IV, Linz, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Many Locations, Multiple Locations, Not set
Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, Not set
Universitätsklinikum AKH Wien, Wien, Not set
Huderf / Ukzkf, Bruxelles - Brussel, Not set
CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel, Not set
UZ Gent, Gent, Not set
UZ Gasthuisberg - Pediatric Nephrology, Leuven, Not set
CHC Montlégia - Pediatrics, Liège, Not set
Many Locations, Multiple Locations, Not set
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais
Hospital Pequeno Principe, Curitiba, Parana
Hosp Clínicas Facult. Med. de Ribeirão Preto / USP, Ribeirão Preto/SP, Sao Paulo
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas, São Paulo, Sao Paulo
Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil, Sao Paulo, SP
Instituto da Crianca e do Adolescente, Sao Paulo, Not set
UMHAT Sveti Georgi, Plovdiv, Not set
SHATPD "Prof. Ivan Mitev", Sofia, Not set
MHAT prof. Stoyan Kirkovitch AD, Stara Zagora, Not set
Alberta Children's Hospital - Nephrology Clinic, Calgary, Alberta
The Hospital for Sick Children (SickKids), Toronto, Ontario
CHU Sainte-Justine, Montreal, Quebec
Many Locations, Multiple Locations, Not set
Všeobecná fakultní nemocnice v Praze, Praha 2, Not set
Fakultní nemocnice v Motole, Praha 5, Not set
Rigshospitalet - Børn og Unge, Copenhagen, Not set
Many Locations, Multiple Locations, Not set
Odense Universitetshospital - HC Andersen Børne og Ungehospital, Odense C, Not set
Aarhus Universitetshospital - Børn og Unge, Århus N, Not set
Helsinki University Hospital | Children's Hospital - Clinical Trial Unit, Nephrology Department, Helsinki, Not set
Many Locations, Multiple Locations, Not set
Tays Service Centre | Tampere University Hospital - Pediatric Early Phase Clinical Trials Unit, Tampere, Not set
Turun yliopistollinen keskussairaala, Turku, Not set
CHU bordeaux - Hopital Pellegrin, BORDEAUX cedex, Not set
CHU de Lyon - Hopital Femme Mère Enfant, Bron, Not set
Hopital Arnaud de Villeneuve CHU Montpellier, Montpellier, Not set
Many Locations, Multiple Locations, Not set
Hopital Robert Debre, Paris, Not set
CHU Strasbourg - Hopital Hautepierre, Strasbourg, Not set
Hôpital des Enfants, TOULOUSE Cedex 9, Not set
Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg
Universitätsklinikum Erlangen, Erlangen, Bayern
Medizinische Hochschule Hannover (MHH) | Zentrum Innere Medizin | Klinik fuer Kardiologie und Angiologie, Hannover, Niedersachsen
Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen
Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen
Universitätsklinikum Essen, Essen, Nordrhein-Westfalen
Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen
Charité / Pädiatrie, Berlin, Not set
Universitätsklinikum Hamburg Eppendorf (UKE), Hamburg, Not set
Many Locations, Multiple Locations, Not set
Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department, Athens, Not set
Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department, Athens, Not set
University General Hospital of Heraklion - Department of Paediatrics, Heraklion, Not set
Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit, Ioannina, Not set
Many Locations, Multiple Locations, Not set
Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit', Thessaloniki, Not set
Semmelweis University, Budapest, Not set
Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set
Many Locations, Multiple Locations, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set
SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont, Szeged, Not set
All India Institute of Medical Sciences (AIIMS) - New Delhi, Delhi, Not set
NRS Medical college, Kolkata, Not set
Clalit Health | Soroka Medical Center - Internal Medicine Department, Beer Sheva, Not set
Wilf Children's Hospital Shaare Zedek Medical Center, Jerusalem, Not set
Many Locations, Multiple Locations, Not set
Health Corporation of Galilee Medical Center, Nahariya, Not set
Clalit Health Services Schneider Children's Medical Center, Petach Tikva, Not set
Dana-Dwek Children's Hospital, Tel Aviv, Not set
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria, Bologna, Emilia-Romagna
Ospedale Pediatrico Bambino Gesù - Nefrologia, Roma, Lazio
IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene, Genova, Liguria
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene, Milano, Lombardia
Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi, Firenze, Not set
Many Locations, Multiple Locations, Not set
A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica, Torino, Not set
Kyungpook National University Hospital, Daegu, Daegu Gwang''yeogsi
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggido
Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnamdo
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Many Locations, Multiple Locations, Not set
Korea University Guro Hospital, Seoul, Not set
Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas, Not set
Klaipeda Children's Hospital, Klaipeda, Not set
Many Locations, Multiple Locations, Not set
Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre, Vilnius, Not set
Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan
Sitio Alfredo Chew Wong | Aguascalientes, Mexico, Aguascalientes, Agguascalientes
Hospital Infantil de México "Dr. Federico Gómez", México D.F., Distrito Federal
Instituto Nacional de Pediatría, México, D.F., Distrito Federal
Hospital Universitario "José Eleuterio González", Monterrey, Nuevo Leon
Instituto Veracruzano en Investigación Clinica SC, Veracruz, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Many Locations, Multiple Locations, Not set
University Medical Center Utrecht, Utrecht, Not set
Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
Many Locations, Multiple Locations, Not set
Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Not set
Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu, Wroclaw, Not set
Hospital Santa Maria | Centro de Investigacao Clinica, Missing, Lisboa
Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set
Hospital Pediátrico de Coimbra I ULS Coimbra, Coimbra, Not set
Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica, Porto, Not set
Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set
Hospital de Sant Joan de Déu, Barcelona, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital la Paz, Madrid, Not set
Many Locations, Multiple Locations, Not set
Hospital Universitario Regional De Malaga - Nefrologia pediatrica, Málaga, Not set
Hospital Universitario Virgen Del Rocio S.L. - Nefrologia pediatrica, Sevilla, Not set
Skåne University Hospital, Lund, Not set
Many Locations, Multiple Locations, Not set
Karolinska University Hospital, Stockholm, Not set
Uppsala University Hospital, Uppsala, Not set
Universitäts-Kinderspital UKBB, Basel, Basel-Stadt
Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud
Hopital des Enfants HUG, Geneva, Not set
Many Locations, Multiple Locations, Not set
Hacettepe Universitesi Tip Fakultesi, Ankara, Not set
Baskent Universitesi Tip Fakultesi Hastanesi, Ankara, Not set
Gazi Universitesi Tip Fakultesi, Ankara, Not set
Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara, Not set
Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics, Istanbul, Not set
Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi, Istanbul, Not set
Marmara University Medical Faculty | Pediatric Nephrology, Istanbul, Not set
Many Locations, Multiple Locations, Not set
NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility, Glasgow, Stratchclyde
Birmingham Children's Hospital, Birmingham, West Midlands
Great Ormond Street Hospital for Children, London, Not set
Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility, Manchester, Not set
Many Locations, Multiple Locations, Not set
Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility, Nottingham, Not set
Conditions: Chronic Kidney Disease, Proteinuria, Children
Post-operative Changes Study
Recruiting
The goal of this observational pilot study is to evaluate the feasibility and acceptability of the protocol to explore the functional post-operative trajectory in a developmentally and neurologically impaired pediatric population.
The main objectives of the study are:
* Objective 1: To evaluate the feasibility and acceptability of the study protocol for children and families living with severe neurological impairment (SNI). To evaluate feasibility the investigators will assess consent rate, pr... Read More
The goal of this observational pilot study is to evaluate the feasibility and acceptability of the protocol to explore the functional post-operative trajectory in a developmentally and neurologically impaired pediatric population.
The main objectives of the study are:
* Objective 1: To evaluate the feasibility and acceptability of the study protocol for children and families living with severe neurological impairment (SNI). To evaluate feasibility the investigators will assess consent rate, protocol delivery and outcome completion. To evaluate acceptability, the investigators will conduct end-of-study interviews with caregivers to assess outcomes related to the ease and utility of participating in the study, including the methods of data collection.
* Objective 2: To explore patterns of recovery in children with SNI during the peri-operative period. To do this, the investigators will be be assessing function in children with SNI, quality of life in children with SNI and their families, and the profile of inflammatory biomarkers during the perioperative period. The investigators will then compare the inflammatory profile of these children with SNI against a group of neurotypical children also undergoing surgery. To assess function and quality of life of the child with SNI, the investigators will be using the Caregivers Priorities and Child Health Index of Life with Disabilities (CPCHILD) Questionnaire. Parents/caregivers will also be asked to answer two supplemental questions to provide further insight into 1) other areas of function that were not described by CPCHILD and 2) the quality of life of the caregivers. To collect information on the peri-operative inflammatory profile of the child with SNI and the control participants, the investigators will collect blood samples at different peri-operative time points. Read Less
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
08/06/2025
Locations: BC Children's Hospital Research Institute, Vancouver, British Columbia
BC Children's Hospital Research Institute, Vancouver, British Columbia
Conditions: Post-operative Functional Decline, Severe Neurological Impairment
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
Recruiting
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC.
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC. Read Less
Gender:
MALE
Ages:
Between 18 years and 130 years
Trial Updated:
08/06/2025
Locations: Research Site, Chandler, Arizona +408 locations
Research Site, Chandler, Arizona
Research Site, Gilbert, Arizona
Research Site, Phoenix, Arizona
Research Site, Tucson, Arizona
Research Site, Little Rock, Arkansas
Research Site, Springdale, Arkansas
Research Site, Bakersfield, California
Research Site, Fountain Valley, California
Research Site, Fullerton, California
Research Site, Los Angeles, California
Research Site, Los Angeles, California
Research Site, Montebello, California
Research Site, Pasadena, California
Research Site, Pomona, California
Research Site, Sacramento, California
Research Site, San Diego, California
Research Site, San Francisco, California
Research Site, Santa Barbara, California
Research Site, Santa Monica, California
Research Site, Santa Rosa, California
Research Site, Golden, Colorado
Research Site, Lakewood, Colorado
Research Site, New Haven, Connecticut
Research Site, Norwich, Connecticut
Research Site, Newark, Delaware
Research Site, Jacksonville, Florida
Research Site, Jacksonville, Florida
Research Site, Palm Bay, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tampa, Florida
Research Site, Atlanta, Georgia
Research Site, Glenview, Illinois
Research Site, Lake Barrington, Illinois
Research Site, Fort Wayne, Indiana
Research Site, Indianapolis, Indiana
Research Site, Des Moines, Iowa
Research Site, Westwood, Kansas
Research Site, Wichita, Kansas
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Shreveport, Louisiana
Research Site, Scarborough, Maine
Research Site, Baltimore, Maryland
Research Site, Baltimore, Maryland
Research Site, Bethesda, Maryland
Research Site, Towson, Maryland
Research Site, Upper Marlboro, Maryland
Research Site, Grand Rapids, Michigan
Research Site, Troy, Michigan
Research Site, Rochester, Minnesota
Research Site, Columbia, Missouri
Research Site, Billings, Montana
Research Site, Bozeman, Montana
Research Site, Las Vegas, Nevada
Research Site, Las Vegas, Nevada
Research Site, Belleville, New Jersey
Research Site, Brick, New Jersey
Research Site, Camden, New Jersey
Research Site, East Brunswick, New Jersey
Research Site, Voorhees, New Jersey
Research Site, Albuquerque, New Mexico
Research Site, Albuquerque, New Mexico
Research Site, Rio Rancho, New Mexico
Research Site, Albany, New York
Research Site, Bronx, New York
Research Site, East Syracuse, New York
Research Site, New Hyde Park, New York
Research Site, New York, New York
Research Site, New York, New York
Research Site, Shirley, New York
Research Site, Syracuse, New York
Research Site, Durham, North Carolina
Research Site, Fayetteville, North Carolina
Research Site, Cincinnati, Ohio
Research Site, Cincinnati, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Columbus, Ohio
Research Site, Independence, Ohio
Research Site, Wooster, Ohio
Research Site, Florence, Oregon
Research Site, Portland, Oregon
Research Site, Portland, Oregon
Research Site, Bala-Cynwyd, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, York, Pennsylvania
Research Site, Providence, Rhode Island
Research Site, Myrtle Beach, South Carolina
Research Site, North Charleston, South Carolina
Research Site, Sioux Falls, South Dakota
Research Site, Germantown, Tennessee
Research Site, Nashville, Tennessee
Research Site, Dallas, Texas
Research Site, Dallas, Texas
Research Site, Denton, Texas
Research Site, Flower Mound, Texas
Research Site, Grapevine, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Plano, Texas
Research Site, San Antonio, Texas
Research Site, San Antonio, Texas
Research Site, Sugar Land, Texas
Research Site, Tyler, Texas
Research Site, Wichita Falls, Texas
Research Site, Saint George, Utah
Research Site, Salt Lake City, Utah
Research Site, Salt Lake City, Utah
Research Site, Fairfax, Virginia
Research Site, Winchester, Virginia
Research Site, Spokane Valley, Washington
Research Site, Spokane, Washington
Research Site, Tacoma, Washington
Research Site, Chermside, Not set
Research Site, Darlinghurst, Not set
Research Site, Hyde Park, Not set
Research Site, Kurralta Park, Not set
Research Site, Melbourne, Not set
Research Site, Randwick, Not set
Research Site, South Brisbane, Not set
Research Site, Graz, Not set
Research Site, Innsbruck, Not set
Research Site, Krems an der Donau, Not set
Research Site, Linz, Not set
Research Site, Wien, Not set
Research Site, Wien, Not set
Research Site, Charleroi, Not set
Research Site, Gent, Not set
Research Site, Kortrijk, Not set
Research Site, Leuven, Not set
Research Site, Curitiba, Not set
Research Site, Pelotas, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Salvador, Not set
Research Site, Sao Luis, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Calgary, Alberta
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Abbotsford, British Columbia
Research Site, Kelowna, British Columbia
Research Site, Vancouver, British Columbia
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, Kingston, Ontario
Research Site, London, Ontario
Research Site, Mississauga, Ontario
Research Site, Newmarket, Ontario
Research Site, Ottawa, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Chicoutimi, Quebec
Research Site, Greenfield Park, Quebec
Research Site, Montreal, Quebec
Research Site, Montréal, Quebec
Research Site, Montréal, Quebec
Research Site, Saskatoon, Saskatchewan
Research Site, Quebec, Not set
Research Site, Concepcion, Not set
Research Site, La Serena, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Temuco, Not set
Research Site, Viña del Mar, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Chongqing, Not set
Research Site, Dongguan, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guilin, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Jiaxing, Not set
Research Site, Jinan, Not set
Research Site, Lanzhou, Not set
Research Site, Nanchang, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nantong, Not set
Research Site, Ningbo, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Shenyang, Not set
Research Site, Shenyang, Not set
Research Site, Suining, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Weifang, Not set
Research Site, Wenzhou, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Yantai, Not set
Research Site, Zhengzhou, Not set
Research Site, Helsinki, Not set
Research Site, Tampere, Not set
Research Site, Turku, Not set
Research Site, Angers, Not set
Research Site, Bayonne, Not set
Research Site, Bordeaux Cedex, Not set
Research Site, Caen Cedex 5, Not set
Research Site, Clermont Ferrand, Not set
Research Site, Creteil, Not set
Research Site, Lyon, Not set
Research Site, Montpellier, Not set
Research Site, Nice, Not set
Research Site, Nîmes, Not set
Research Site, Paris, Not set
Research Site, Pierre Bénite, Not set
Research Site, Poitiers Cedex, Not set
Research Site, Quimper Cedex, Not set
Research Site, Rennes Cedex 9, Not set
Research Site, Strasbourg, Not set
Research Site, Tours, Not set
Research Site, Vandoeuvre les Nancy, Not set
Research Site, Bergisch Gladbach, Not set
Research Site, Berlin, Not set
Research Site, Bonn, Not set
Research Site, Braunschweig, Not set
Research Site, Dresden, Not set
Research Site, Duisburg, Not set
Research Site, Erlangen, Not set
Research Site, Frankfurt am Main, Not set
Research Site, Frankfurt, Not set
Research Site, Freiburg, Not set
Research Site, Göttingen, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Herne, Not set
Research Site, Homburg, Not set
Research Site, Köln, Not set
Research Site, Magdeburg, Not set
Research Site, Mannheim, Not set
Research Site, Marburg, Not set
Research Site, Mettmann, Not set
Research Site, München, Not set
Research Site, Münster, Not set
Research Site, Nürtingen, Not set
Research Site, Oldenburg, Not set
Research Site, Regensburg, Not set
Research Site, Stuttgart, Not set
Research Site, Trier, Not set
Research Site, Tübingen, Not set
Research Site, Ulm, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Győr, Not set
Research Site, Miskolc, Not set
Research Site, Nyíregyháza, Not set
Research Site, Szeged, Not set
Research Site, Szekszárd, Not set
Research Site, Bangalore, Not set
Research Site, Calicut, Not set
Research Site, Delhi, Not set
Research Site, Hyderabad, Not set
Research Site, JAipur, Not set
Research Site, Kanpur, Not set
Research Site, Kolkata, Not set
Research Site, Kolkata, Not set
Research Site, Mohali, Not set
Research Site, Nagpur, Not set
Research Site, New Delhi, Not set
Research Site, New Delhi, Not set
Research Site, Pune, Not set
Research Site, Surat, Not set
Research Site, Vadodara, Not set
Research Site, Varanasi, Not set
Research Site, Bari, Not set
Research Site, Genoa, Not set
Research Site, Meldola, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Napoli, Not set
Research Site, Padova, Not set
Research Site, Rome, Not set
Research Site, Rozzano, Not set
Research Site, Terni, Not set
Research Site, Trento, Not set
Research Site, Chiba-shi, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Fukuoka, Not set
Research Site, Hirakata-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Kanazawa-shi, Not set
Research Site, Kashihara-shi, Not set
Research Site, Kawagoe-shi, Not set
Research Site, Kisarazu-shi, Not set
Research Site, Kita-gun, Not set
Research Site, Kobe-shi, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Maebashi-shi, Not set
Research Site, Nagano-shi, Not set
Research Site, Nagasaki-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sakura-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Shiwa-gun, Not set
Research Site, Suita-shi, Not set
Research Site, Tsu-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yufu-shi, Not set
Research Site, Daejeon, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon, Not set
Research Site, George Town, Not set
Research Site, Johor Bahru, Not set
Research Site, Kota Kinabalu, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuching, Not set
Research Site, Amsterdam, Not set
Research Site, Hilversum, Not set
Research Site, Nijmegen, Not set
Research Site, Arequipa, Not set
Research Site, Bellavista, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Bydgoszcz, Not set
Research Site, Koszalin, Not set
Research Site, Poznań, Not set
Research Site, Rzeszów, Not set
Research Site, Szczecin, Not set
Research Site, Warszawa, Not set
Research Site, Wrocław, Not set
Research Site, Żory, Not set
Research Site, San Juan, Not set
Research Site, Barcelona, Not set
Research Site, Córdoba, Not set
Research Site, L'Hospitalet de Llobregat, Not set
Research Site, Lugo, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Sabadell, Not set
Research Site, Valencia, Not set
Research Site, Göteborg, Not set
Research Site, Malmo, Not set
Research Site, Solna, Not set
Research Site, Stockholm, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Taoyuan, Not set
Research Site, Yung Kang City, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Chiang Mai, Not set
Research Site, Khlong Luang, Not set
Research Site, Songkla, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Bornova-Izmir, Not set
Research Site, Fatih-Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Karsiyaka, Not set
Research Site, Aberdeen, Not set
Research Site, Birmingham, Not set
Research Site, Cambridge, Not set
Research Site, Glasgow, Not set
Research Site, Guildford, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Newcastle upon Tyne, Not set
Research Site, Oxford, Not set
Research Site, Plymouth, Not set
Research Site, Preston, Not set
Research Site, Swansea, Not set
Research Site, Truro, Not set
Conditions: Metastatic Castration-Sensitive Prostate Cancer
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
Recruiting
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%.
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Research Site, Prescott, Arizona +297 locations
Research Site, Prescott, Arizona
Research Site, Hot Springs National Park, Arkansas
Research Site, Springdale, Arkansas
Research Site, Long Beach, California
Research Site, Palo Alto, California
Research Site, Lone Tree, Colorado
Research Site, Newark, Delaware
Research Site, Fort Myers, Florida
Research Site, Gainesville, Florida
Research Site, Orlando, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tallahassee, Florida
Research Site, West Palm Beach, Florida
Research Site, Fort Wayne, Indiana
Research Site, Indianapolis, Indiana
Research Site, Des Moines, Iowa
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Baton Rouge, Louisiana
Research Site, Marrero, Louisiana
Research Site, Annapolis, Maryland
Research Site, Baltimore, Maryland
Research Site, Baltimore, Maryland
Research Site, Silver Spring, Maryland
Research Site, Towson, Maryland
Research Site, Detroit, Michigan
Research Site, Hattiesburg, Mississippi
Research Site, Grand Island, Nebraska
Research Site, Lincoln, Nebraska
Research Site, Omaha, Nebraska
Research Site, Belleville, New Jersey
Research Site, Albany, New York
Research Site, East Syracuse, New York
Research Site, Fresh Meadows, New York
Research Site, Westbury, New York
Research Site, Cleveland, Ohio
Research Site, Columbus, Ohio
Research Site, Columbus, Ohio
Research Site, Dayton, Ohio
Research Site, Portland, Oregon
Research Site, Horsham, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Memphis, Tennessee
Research Site, Nashville, Tennessee
Research Site, Nashville, Tennessee
Research Site, Houston, Texas
Research Site, Irving, Texas
Research Site, Lancaster, Texas
Research Site, Fairfax, Virginia
Research Site, Henrico, Virginia
Research Site, Tacoma, Washington
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Ciudad de Córdoba, Not set
Research Site, Córdoba, Not set
Research Site, La Plata, Not set
Research Site, La Plata, Not set
Research Site, Rosario, Not set
Research Site, Clayton, Not set
Research Site, Fitzroy, Not set
Research Site, Heidelberg, Not set
Research Site, South Brisbane, Not set
Research Site, Sydney, Not set
Research Site, Linz, Not set
Research Site, Wels, Not set
Research Site, Aalst, Not set
Research Site, Antwerpen, Not set
Research Site, Gent, Not set
Research Site, Barretos, Not set
Research Site, Curitiba, Not set
Research Site, Florianópolis, Not set
Research Site, Fortaleza, Not set
Research Site, Natal, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio De Janeiro, Not set
Research Site, Santa Cruz do Sul, Not set
Research Site, Sao Paulo, Not set
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, Barrie, Ontario
Research Site, Oshawa, Ontario
Research Site, Toronto, Ontario
Research Site, Levis, Quebec
Research Site, Trois-Rivières, Quebec
Research Site, Chicoutimi, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Bengbu, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Fuzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hefei, Not set
Research Site, Hefei, Not set
Research Site, Lanzhou, Not set
Research Site, Linhai, Not set
Research Site, Linyi, Not set
Research Site, Nanchang, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nanning, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenzhen, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Yangzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Olomouc, Not set
Research Site, Ostrava - Vitkovice, Not set
Research Site, Praha, Not set
Research Site, Praha, Not set
Research Site, Angers, Not set
Research Site, Avignon, Not set
Research Site, Bayonne, Not set
Research Site, Bordeaux, Not set
Research Site, Caen, Not set
Research Site, Lille, Not set
Research Site, Limoges, Not set
Research Site, Marseille, Not set
Research Site, Montpellier, Not set
Research Site, Paris Cedex 5, Not set
Research Site, Quimper, Not set
Research Site, Reims, Not set
Research Site, Saint-Malo, Not set
Research Site, Strasbourg Cedex, Not set
Research Site, Suresnes, Not set
Research Site, Toulon Naval, Not set
Research Site, Berlin-Zehlendorf, Not set
Research Site, Bonn, Not set
Research Site, Bonn, Not set
Research Site, Braunschweig, Not set
Research Site, Dresden, Not set
Research Site, Essen, Not set
Research Site, Freiburg, Not set
Research Site, Gauting, Not set
Research Site, Georgsmarienhuette, Not set
Research Site, Gütersloh, Not set
Research Site, Halle, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Immenhausen, Not set
Research Site, Koblenz, Not set
Research Site, Ludwigsburg, Not set
Research Site, Nürnberg, Not set
Research Site, Tuebingen, Not set
Research Site, Velbert, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Deszk, Not set
Research Site, Gyöngyös - Mátraháza, Not set
Research Site, Gyöngyös, Not set
Research Site, Győr, Not set
Research Site, Kecskemét, Not set
Research Site, Pécs, Not set
Research Site, Szekszárd, Not set
Research Site, Székesfehérvár, Not set
Research Site, Törökbálint, Not set
Research Site, Bengaluru, Not set
Research Site, Delhi, Not set
Research Site, Hyderabad, Not set
Research Site, Kolkata, Not set
Research Site, Kolkata, Not set
Research Site, Mysuru, Not set
Research Site, Nagpur, Not set
Research Site, Nashik, Not set
Research Site, New Delhi, Not set
Research Site, Varanasi, Not set
Research Site, Bari, Not set
Research Site, Bergamo, Not set
Research Site, Catanzaro, Not set
Research Site, Milano, Not set
Research Site, Padova, Not set
Research Site, Parma, Not set
Research Site, Pavia, Not set
Research Site, Ravenna, Not set
Research Site, Roma, Not set
Research Site, Roma, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Kawasaki-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sapporo-Shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Ube-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Cheongju-si, Not set
Research Site, Daegu, Not set
Research Site, Incheon, Not set
Research Site, Jinju-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Suwon, Not set
Research Site, Ciudad de México, Not set
Research Site, Ciudad de México, Not set
Research Site, Culiacan, Not set
Research Site, Guadalajara, Not set
Research Site, Guadalajara, Not set
Research Site, Mexico City, Not set
Research Site, Monterrey, Not set
Research Site, Naucalpan, Not set
Research Site, Amsterdam, Not set
Research Site, Groningen, Not set
Research Site, Nieuwegein, Not set
Research Site, Tilburg, Not set
Research Site, Lublin, Not set
Research Site, Olsztyn, Not set
Research Site, Poznań, Not set
Research Site, Przemysl, Not set
Research Site, Radom, Not set
Research Site, Rzeszów, Not set
Research Site, Szklarska Poręba, Not set
Research Site, Tomaszów Mazowiecki, Not set
Research Site, Toruń, Not set
Research Site, Warszawa, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Banska Bystrica, Not set
Research Site, Bratislava, Not set
Research Site, Bratislava, Not set
Research Site, Kosice, Not set
Research Site, Trnava, Not set
Research Site, Amanzimtoti, Not set
Research Site, Bloemfontein, Not set
Research Site, George, Not set
Research Site, Johannesburg, Not set
Research Site, Johannesburg, Not set
Research Site, Pietermaritzburg, Not set
Research Site, Pretoria, Not set
Research Site, Rondebosch, Not set
Research Site, Soweto, Not set
Research Site, Alicante, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Bilbao (Vizcaya), Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Palma, Not set
Research Site, Hsinchu, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, New Taipei, Not set
Research Site, Tainan City, Not set
Research Site, Tainan, Not set
Research Site, Taipei City, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan, Not set
Research Site, Yunlin, Not set
Research Site, Lampang, Not set
Research Site, Muang, Not set
Research Site, Songkhla, Not set
Research Site, Ankara, Not set
Research Site, Antalya, Not set
Research Site, Diyarbakir, Not set
Research Site, Fatih-Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, İzmir, Not set
Research Site, Pamukkale, Not set
Research Site, Çankaya, Not set
Research Site, Birmingham, Not set
Research Site, Blackpool, Not set
Research Site, Bury St Edmunds, Not set
Research Site, Colchester, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Truro, Not set
Conditions: Metastatic Non-small Cell Lung Cancer
A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 1)
Recruiting
This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6.
This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Dermatology Research Associates - Los Angeles- Site Number : 8400004, Los Angeles, California +56 locations
Dermatology Research Associates - Los Angeles- Site Number : 8400004, Los Angeles, California
Michigan Center for Research Company- Site Number : 8400013, Clarkston, Michigan
Equity Medical- Site Number : 8400017, New York, New York
Red River Research Partners - Fargo- Site Number : 8400007, Fargo, North Dakota
MedCare Pharma - Houston - Cypress Creek Parkway- Site Number : 8400014, Houston, Texas
Care Access - Arlington- Site Number : 8400022, Arlington, Virginia
Investigational Site Number : 0320003, Rosario, Santa Fe
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320004, Buenos Aires, Not set
Investigational Site Number : 0320002, Mendoza, Not set
Investigational Site Number : 1240005, Edmonton, Alberta
Investigational Site Number : 1240001, London, Ontario
Investigational Site Number : 1240007, Mississauga, Ontario
Investigational Site Number : 1240009, Montreal, Quebec
Investigational Site Number : 1240008, Québec City, Quebec
Investigational Site Number : 1240010, Regina, Saskatchewan
Investigational Site Number : 1240002, Saskatoon, Saskatchewan
Investigational Site Number : 1520002, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520003, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1560002, Beijing, Not set
Investigational Site Number : 1560004, Hangzhou, Not set
Investigational Site Number : 1560001, Shanghai, Not set
Investigational Site Number : 1560003, Shijiazhuang, Not set
Investigational Site Number : 1560005, Suzhou, Not set
Investigational Site Number : 2030001, Ostrava, Not set
Investigational Site Number : 2760003, Bad Bentheim, Not set
Investigational Site Number : 2760002, Lübeck, Not set
Investigational Site Number : 2760001, Magdeburg, Not set
Investigational Site Number : 3000001, Athens, Not set
Investigational Site Number : 3000002, Thessaloniki, Not set
Investigational Site Number : 3000003, Thessaloniki, Not set
Investigational Site Number : 3480001, Debrecen, Not set
Investigational Site Number : 3480002, Kaposvár, Not set
Investigational Site Number : 3800001, Rome, Roma
Investigational Site Number : 3800002, Bologna, Not set
Investigational Site Number : 3920002, Ebina-shi, Kanagawa
Investigational Site Number : 3920001, Kamiamakusa, Kumamoto
Investigational Site Number : 3920007, Sakai, Osaka
Investigational Site Number : 3920003, Tachikawa, Tokyo
Investigational Site Number : 3920009, Fukuoka, Not set
Investigational Site Number : 3920005, Kagoshima, Not set
Investigational Site Number : 4840001, Chihuahua, Not set
Investigational Site Number : 6200002, Coimbra, Not set
Investigational Site Number : 6200003, Lisbon, Not set
Investigational Site Number : 6200001, Porto, Not set
Investigational Site Number : 7240003, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240005, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 7240002, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 7240004, Valencia, Not set
Investigational Site Number : 1580002, Kaohsiung City, Not set
Investigational Site Number : 1580001, Taipei City, Not set
Investigational Site Number : 7920003, Adapazari, Not set
Investigational Site Number : 7920002, Istanbul, Not set
Investigational Site Number : 7920001, Samsun, Not set
Investigational Site Number : 8260002, Milton Keynes, Buckinghamshire
Investigational Site Number : 8260001, London, England
Conditions: Lichen Simplex Chronicus
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