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                    All Clinical Trials in Canada
A listing of 3905  clinical trials  actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
            541 - 552 of 3905
        
                
                                    A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
                                
            
            
        Recruiting
                            
            
                This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC).             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Highlands Oncology Group, Springdale, Arkansas  +229 locations         
        
        
            Conditions: Small Cell Lung Cancer
        
            
        
    
                
                                    Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
                                
            
            
        Recruiting
                            
            
                This is a parallel, Phase 3, 2-arm study to evaluate the efficacy and long-term safety of dupilumab treatment in children 2 to \<6 years of age with uncontrolled asthma and/or recurrent severe asthmatic wheeze. The study will be conducted in 2 parts. Part A will be a 52-week, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of dupilumab in children aged 2 to \<6 years old with uncontrolled asthma and/or recurrent severe asthmatic wheeze. At the end of Part A,...  Read More             
        
        
    Gender:
                ALL
            Ages:
                Between 2 years and 5 years
            Trial Updated:
                08/06/2025
            
            Locations: Phoenix Children's Hospital- Site Number : 8400001, Phoenix, Arizona  +73 locations         
        
        
            Conditions: Wheezing, Asthma
        
            
        
    
                
                                    First in Human Study of AZD9592 in Solid Tumors
                                
            
            
        Recruiting
                            
            
                This is a first-in-human (FIH) Phase I, multi-center, open-label, study of AZD9592, in patients with advanced solid tumors. The study consists of several study modules, each evaluating the safety, tolerability, preliminary efficacy, pharmacokinetics (PK), pharmacodynamics, anti-tumor activity, and immunogenicity of AZD9592, as monotherapy or in combination with anti-cancer agents.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Research Site, Duarte, California  +49 locations         
        
        
            Conditions: Advanced Solid Tumours, Carcinoma Non-small Cell Lung, Head and Neck Neoplasms, Colorectal Neoplasms
        
            
        
    
                
                                    A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced Participants With Active Psoriatic Arthritis
                                
            
            
        Recruiting
                            
            
                The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in biologic-experienced participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: AARA Clinical Research, Glendale, Arizona  +194 locations         
        
        
            Conditions: Arthritis, Psoriatic
        
            
        
    
                
                                    A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 2)
                                
            
            
        Recruiting
                            
            
                This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Center for Dermatology Clinical Research- Site Number : 8400226, Fremont, California  +56 locations         
        
        
            Conditions: Lichen Simplex Chronicus
        
            
        
    
                
                                    A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
                                
            
            
        Recruiting
                            
            
                This study is a Phase IIIb/IV, multicenter, randomized, two-arm, open-label 100-week study to investigate the efficacy, safety, and durability of intravitreal 6-mg faricimab administered at up to 24-week intervals in patients with neovascular age-related macular degeneration (nAMD) that are treatment-naïve in the study eye.             
        
        
    Gender:
                ALL
            Ages:
                50 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Retinal Diagnostic Center, Campbell, California  +48 locations         
        
        
            Conditions: Neovascular Age-related Macular Degeneration (nAMD)
        
            
        
    
                
                                    A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada
                                
            
            
        Recruiting
                            
            
                Acute Myeloid Leukemia (AML) is a cancer of the blood and bone marrow and is the most common acute leukemia in adults. This study will evaluate how well venetoclax works to treat AML in adult participants who are ineligible for intensive induction chemotherapy in Canada.
Venetoclax is a drug approved to treat Acute Myeloid Leukemia (AML). All study participants will receive Venetoclax as prescribed by their study doctor in accordance with approved local label. Adult participants with a new diag...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Tom Baker Cancer Centre /ID# 248113, Calgary, Alberta  +19 locations         
        
        
            Conditions: Acute Myeloid Leukemia
        
            
        
    
                
                                    Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation
                                
            
            
        Recruiting
                            
            
                The primary purpose of this registry is to obtain real-world clinical experience of Paroxysmal (PAF) and Persistent (PsAF) Atrial Fibrillation ablation radiofrequency (RF) technologies. Data from the registry will be used to assess clinical outcomes, including procedural efficiency, safety, and long-term, effectiveness of catheter ablation with novel RF technologies in PAF and PsAF patients.             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: University of Alabama at Birmingham, Birmingham, Alabama  +65 locations         
        
        
            Conditions: Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
        
            
        
    
                
                                    Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV.
                                
            
            
        Recruiting
                            
            
                The main objective of this study is to explore the efficacy of avacopan in participants affected by AAV.             
        
        
    Gender:
                ALL
            Ages:
                Between 6 years and 17 years
            Trial Updated:
                08/06/2025
            
            Locations: Emory University, Atlanta, Georgia  +27 locations         
        
        
            Conditions: Vasculitis
        
            
        
    
                
                                    Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
                                
            
            
        Recruiting
                            
            
                This clinical trial is designed to assess the efficacy and safety of the triplet combination of trastuzumab deruxtecan (ENHERTU, T-DXd, DS-8201a) plus a fluoropyrimidine plus pembrolizumab versus standard of care (SoC) chemotherapy plus trastuzumab plus pembrolizumab as first-line therapy in participants with unresectable, locally advanced or metastatic HER2-positive tumor PD-L1 CPS ≥1 gastric or GEJ cancer in the Main Cohort. An Exploratory Cohort will also be evaluated to assess the efficacy a...  Read More             
        
        
    Gender:
                ALL
            Ages:
                18 years and above
            Trial Updated:
                08/06/2025
            
            Locations: Yale Cancer Center, New Haven, Connecticut  +244 locations         
        
        
            Conditions: Gastric Cancer, Gastroesophageal Junction Cancer
        
            
        
    
                
                                    Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
                                
            
            
        Recruiting
                            
            
                This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis             
        
        
    Gender:
                ALL
            Ages:
                Between 12 years and 100 years
            Trial Updated:
                08/06/2025
            
            Locations: Childrens Hospital Colorado, Aurora, Colorado  +43 locations         
        
        
            Conditions: C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis
        
            
        
    
                
                                    Met Non Small Cell Cancer Registry (MOMENT)
                                
            
            
        Recruiting
                            
            
                The purpose of this multi-national disease registry is to collect prospectively (with longitudinal follow-up) high-quality, standardized, and contemporaneous data to capture changes in the non-small cell lung cancer (NSCLC) treatment landscape and outcomes over time.
The registry will capture data on participants; demographic, clinical characteristics (including biomarker data), treatment patterns, and effectiveness and safety outcomes for advanced NSCLC with mesenchymal-epithelial transition e...  Read More             
        
        
    Gender:
                ALL
            Ages:
                All
            Trial Updated:
                08/06/2025
            
            Locations: Holy Cross Health, Fort Lauderdale, Florida  +63 locations         
        
        
            Conditions: Cancer
        
            
        
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