Individualized Fortification of Human Milk for Infants Born ≤ 1250 g (MaxiMoM-InForM)
NCT05308134
Recruiting
Very low birth weight infants have increased nutritional needs. Extra nutrients are added to their human milk feeds to help improve their nutritional status, growth and neurodevelopment. Standard fortification of human milk is routine in most neonatal units in North America, but despite the added nutrients, infants are often discharged from hospitals with poor growth, and their neurodevelopment remains suboptimal. Two individualized fortification methods, target and BUN adjustable, have been pro... Read More
Gender:
ALL
Ages:
21 days and below
Trial Updated:
07/30/2025
Locations: University of Alberta, Edmonton, Alberta +19 locations
Conditions: Very Low Birth Weight Infant
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A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
NCT06388564
Recruiting
This study will be conducted to determine the preliminary efficacy of axatilimab in combination with ruxolitinib and to assess the contribution of axatilimab to the combination treatment effect in participants with cGVHD.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/30/2025
Locations: Mayo Clinic Hospital, Phoenix, Arizona +69 locations
Conditions: Chronic Graft-versus-host-disease
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Non-invasive Ventilation and Dexmedetomidine in Critically Ill Adults
NCT06259565
Recruiting
Non-Invasive ventilation (NIV) is a life saving intervention for patients with acute respiratory failure (ARF). Some patients are not able to tolerate the NIV intervention and ultimately fail, requiring the use of invasive mechanical ventilation (IMV) and intubation. Sedation may improve a patient's NIV tolerance. However, this practice has not been adopted by intensivists as the risk of over-sedation resulting in respiratory depression, inability to protect the airway, and inadvertent need for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Fraser Health Authority, Surrey, British Columbia +5 locations
Conditions: Non-Invasive Ventilation
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A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
NCT05050136
Recruiting
The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Biliary Cholangitis (PBC), and to assess the possible impact on the disease progression of PBC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Southern California Research Center, Coronado, California +101 locations
Conditions: Primary Biliary Cholangitis, PBC
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Feasibility of Choose to Move Replacement Ready
NCT07069179
Recruiting
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR/THR) for osteoarthritis (OA). The primary goal of this observational study is to learn if the adapted program, Choose to Move Replacement Ready (CTM-RR), is feasible to deliver to people wi... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
07/30/2025
Locations: Active Aging Research Team, Robert H. N. Ho Research Centre, Vancouver, British Columbia
Conditions: Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis, Hip, Total Knee Arthroplasty; Total Hip Arthroplasty, Mobility Limitation, Social Isolation or Loneliness, Pain, Implementation Science, Physical Inactivity, Sedentary Behaviors
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Tibulizumab Skin Healing and Inflammation Evaluation for Lasting Defense
NCT06993610
Recruiting
The study is a Phase 2, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of tibulizumab over 16 weeks (Period 1) in adults with hidradenitis suppurativa, followed by a 16-week open-label extension period in which all participants will receive tibulizumab (Period 2)
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/30/2025
Locations: NorCal Clinical Research, Rocklin, California +21 locations
Conditions: Hidradenitis Suppurativa (HS)
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Prospective Evaluation of Breast-Conserving Surgery Alone in Low-Risk Ductal Carcinoma in Situ (DCIS)
NCT04797299
Recruiting
To evaluate whether the combination of clinicopathological factors and the use of the Oncotype DX DCIS score can avoid radiation in women with low risk DCIS who have had breast conserving surgery (BCS)
Gender:
FEMALE
Ages:
46 years and above
Trial Updated:
07/30/2025
Locations: Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta +21 locations
Conditions: DCIS
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CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
NCT05681351
Recruiting
The purpose of this study is to evaluate the safety and tolerability of olezarsen in participants with SHTG.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: LA Universal Research Center, Inc., Los Angeles, California +261 locations
Conditions: Severe Hypertriglyceridemia
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Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
NCT05615844
Recruiting
The Beads vs Vac trial is a multi-centre randomized controlled trial of 312 participants with a severe open tibia fracture requiring multiple irrigation and debridement surgeries. Eligible participants will be randomized to receive either an antibiotic bead pouch or negative pressure wound therapy (NPWT) for their temporary open fracture wound management. Outcomes will be assessed at 6 weeks, 3 months, and 6 months post-surgery. The primary outcome will be a composite outcome to evaluate clinica... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Dignity Health Chandler Regional Medical Center, Chandler, Arizona +23 locations
Conditions: Open tíbia Fracture
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A Registry for People With Lung Cancer
NCT06424327
Recruiting
Participants will complete questionnaires before surgery, between 2 to 4 weeks after surgery, and 6 months after surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Rush University Medical Center (Data collection only), Chicago, Illinois +9 locations
Conditions: Lung Cancer, Lung Cancer Stage I
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EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
NCT06531824
Recruiting
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. Th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Apogee Clinical Research, Huntsville, Alabama +161 locations
Conditions: Kidney Disease, Chronic
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Combined Pulsed Field and Radiofrequency Energy for Ablation of Ventricular Tachycardia
NCT06816368
Recruiting
This will be a single arm study evaluating a new ablation technology for performing catheter ablation of ventricular tachycardia. The technology combines novel pulsed field ablation with radiofrequency ablation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: McGill University Health Centre, Montreal, Quebec +2 locations
Conditions: Ventricular Tachycardia (V-Tach)
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