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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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Pompe Disease Registry Protocol
Recruiting
The Pompe Registry is a global, multicenter, international, longitudinal, observational, and voluntary program for patients with Pompe disease, designed to track the disease's natural history and outcomes in patients, both treated and not. Data from the Registry are also used to fulfill various global regulatory commitments, to support product development/reimbursement, and for other research and non-research related purposes.
The objectives of the Registry are:
* To enhance understanding of t... Read More
The Pompe Registry is a global, multicenter, international, longitudinal, observational, and voluntary program for patients with Pompe disease, designed to track the disease's natural history and outcomes in patients, both treated and not. Data from the Registry are also used to fulfill various global regulatory commitments, to support product development/reimbursement, and for other research and non-research related purposes.
The objectives of the Registry are:
* To enhance understanding of the variability, progression, identification, and natural history of Pompe disease, with the ultimate goal of better guiding and assessing therapeutic intervention.
* To assist the Pompe medical community with the development of recommendations for monitoring patients, and to provide reports on patient outcomes, to optimize patient care.
* To characterize the Pompe disease population.
* To evaluate the long-term effectiveness of alglucosidase alfa. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
08/06/2025
Locations: University Alabama at Birmingham- Site Number : 840106, Birmingham, Alabama +270 locations
University Alabama at Birmingham- Site Number : 840106, Birmingham, Alabama
Barrow Neurological Institute- Site Number : 840087, Phoenix, Arizona
Phoenix Children's Hospital- Site Number : 840003, Phoenix, Arizona
University of Arizona- Site Number : 840015, Tucson, Arizona
Arkansas Childrens Hospital- Site Number : 840109, Little Rock, Arkansas
University of Arkansas for Medical Sciences- Site Number : 840113, Little Rock, Arkansas
University of California at Irvine- Site Number : 840036, Irvine, California
Loma Linda University- Genetics- Site Number : 840070, Loma Linda, California
Southern California Permanente Medical Group- Site Number : 840108, Los Angeles, California
USC Health Sciences Center Dept of Genetics- Site Number : 840082, Los Angeles, California
Children's Hospital Oakland- Site Number : 840029, Oakland, California
Children's Hospital of Orange County- Site Number : 840074, Orange, California
UC Davis MIND Institute- Site Number : 840010, Sacramento, California
University of California at San Diego- Site Number : 840007, San Diego, California
University of California at San Francisco- Site Number : 840051, San Francisco, California
Stanford University Pediatrics- Site Number : 840021, Stanford, California
Children's Hospital Colorado - Aurora- Site Number : 840069, Aurora, Colorado
Yale - Site Number : 840047, New Haven, Connecticut
Children's National Medical Center- Site Number : 840067, Washington, District of Columbia
University of Florida College of Medicine- Site Number : 840012, Gainesville, Florida
University of Florida Pediatrics Genetics- Site Number : 840121, Jacksonville, Florida
University Of Miami SOM- Site Number : 840006, Miami, Florida
University of Florida-Genetics- Site Number : 840096, Tampa, Florida
Emory University School of Medicine- Human Genetics- Site Number : 840060, Decatur, Georgia
University of Colorado at Denver Genetics- Site Number : 840068, Aurora, Illinois
Ann and Robert Lurie Children's Hospital- Site Number : 840011, Chicago, Illinois
Ann and Robert Lurie Children's Hospital- Site Number : 840013, Chicago, Illinois
Rush University Medical Center Genetics- Site Number : 840079, Chicago, Illinois
Indianapolis University School of Medicine- Site Number : 840027, Indianapolis, Indiana
University of Iowa- Site Number : 840032, Iowa City, Iowa
University of Kansas Medical Center- Site Number : 840020, Kansas City, Kansas
University of Louisville- Genetics- Site Number : 840030, Louisville, Kentucky
Maine Medical Center Pediatrics- Site Number : 840064, Portland, Maine
John Hopkins- Site Number : 840044, Baltimore, Maryland
Massachusetts General Hospital-Genetics- Site Number : 840062, Boston, Massachusetts
Boston Children's Hospital- Site Number : 840092, Boston, Massachusetts
Baystate Health- Site Number : 840002, Springfield, Massachusetts
University of Michigan Pediatrics- Site Number : 840107, Ann Arbor, Michigan
Children's Hospital of Michigan- Site Number : 840066, Detroit, Michigan
Spectrum for Health- Site Number : 840019, Grand Rapids, Michigan
Infusion Associates- Site Number : 840050, Grand Rapids, Michigan
Children's Health Care- Site Number : 840114, Minneapolis, Minnesota
Children's Hospital and Clinics of Minnesota- Site Number : 840046, Minneapolis, Minnesota
University of Minnesota Medical Center Pediatrics- Site Number : 840035, Minneapolis, Minnesota
University of Minnesota Medical Center Pediatrics- Site Number : 840076, Minneapolis, Minnesota
University of Missouri Health System Department of Genetics- Site Number : 840031, Columbia, Missouri
Children's Mercy Hospital- Pediatrics- Site Number : 840063, Kansas City, Missouri
Washington University of St. Louis- Site Number : 840100, Saint Louis, Missouri
University of Nebraska Medical Center- Pediatrics- Site Number : 840084, Omaha, Nebraska
Children's Specialty Center of Nevada- Site Number : 840008, Las Vegas, Nevada
Cooper Health Center- Site Number : 840098, Camden, New Jersey
Hackensack University Medical Center- Site Number : 840101, Hackensack, New Jersey
Atlantic Health System- Site Number : 840099, Morristown, New Jersey
St. Peter's University Hospital- Site Number : 840016, New Brunswick, New Jersey
St. Joseph's Children's Hospital- Site Number : 840057, Paterson, New Jersey
Northwell Health- Site Number : 840102, Manhasset, New York
New York University School Of Medicine- Site Number : 840040, New York, New York
Metropolitan Hospital Center- Site Number : 840110, New York, New York
Mt. Sinai School of Medicine- Site Number : 840005, New York, New York
University of Rochester Medical Center SOM- Site Number : 840105, Rochester, New York
State University of New York- Site Number : 840052, Syracuse, New York
New York Medical College- Site Number : 840039, Valhalla, New York
Carolinas Medical Center Hospital- Site Number : 840065, Charlotte, North Carolina
Duke University Medical Center Genetics Dept- Site Number : 840037, Durham, North Carolina
University of Cincinnati Cancer Institute- Site Number : 840124, Cincinnati, Ohio
Cincinnati Children's Hospital-Genetics- Site Number : 840041, Cincinnati, Ohio
University Hospitals Cleveland Medical Center- Site Number : 840119, Cleveland, Ohio
Cleveland Clinic Foundation Pediatrics- Site Number : 840048, Cleveland, Ohio
Nationwide Children's Hospital- Site Number : 840091, Columbus, Ohio
LSD Data Registry Site LLC- Site Number : 840094, Dublin, Ohio
Oregon Health & Sciences University- Site Number : 840080, Portland, Oregon
Oregon Health and Science University- Site Number : 840095, Portland, Oregon
Oregon Health and Scinece University- Site Number : 840038, Portland, Oregon
Penn Hershey Medical Center- Site Number : 840061, Hershey, Pennsylvania
Penn State Health Milton South Hershey Medical Center- Site Number : 840126, Hershey, Pennsylvania
Children's Hospital of Philadelphia HUP Medical Genetics- Site Number : 840089, Philadelphia, Pennsylvania
Children's Hospital of Philadelphia- Site Number : 840034, Philadelphia, Pennsylvania
UPMC- Site Number : 840014, Pittsburgh, Pennsylvania
University of Pittsburgh- Site Number : 840023, Pittsburgh, Pennsylvania
Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Greenwood Genetcs- Site Number : 840055, Greenville, South Carolina
Vanderbilt University Hospital-Pediatrics- Site Number : 840049, Nashville, Tennessee
Baylor Research Center- Site Number : 840058, Dallas, Texas
Cook Children's Health Care System- Site Number : 840024, Fort Worth, Texas
University of Utah Department of Medical Genetics- Site Number : 840043, Salt Lake City, Utah
University of Virginia School of Medicine-Pediatrics- Site Number : 840078, Charlottesville, Virginia
O&O Alpan, LLC- Site Number : 840025, Fairfax, Virginia
Children's Hospital of the Kings Daughters- Site Number : 840072, Norfolk, Virginia
Seattle Children's Hospital- Site Number : 840028, Seattle, Washington
University Of Washington Medical Center- Site Number : 840059, Seattle, Washington
Multicare Health System ¿ Mary Bridge Childrens Hospital- Site Number : 840115, Tacoma, Washington
Children's Hospital of Wisconsin-Pediatrics- Site Number : 840054, Milwaukee, Wisconsin
Investigational Site Number : 152218, Caba, Buenos Aires
Investigational Site Number : 153194, Caba, Buenos Aires
Investigational Site Number : 153032, Ciudad Autónoma de Buenos Aires, Buenos Aires
Investigational Site Number : 036013, Westmead, New South Wales
Investigational Site Number : 151069, Westmead, New South Wales
Investigational Site Number : 154087, Brisbane, Queensland
Investigational Site Number : 152096, Brisbane, Queensland
Investigational Site Number : 151015, Murdoch, Western Australia
Investigational Site Number : 150722, Antwerp, Not set
Investigational Site Number : 154298, Bruges, Not set
Investigational Site Number : 056010, Brussels, Not set
Investigational Site Number : 150684, Bruxelles, Not set
Investigational Site Number : 152072, Edegem, Not set
Investigational Site Number : 152295, Gent, Not set
Investigational Site Number : 153179, Gosselies, Not set
Investigational Site Number : 151668, Leuven, Not set
Investigational Site Number : 152126, Leuven, Not set
Hospital Universitario Walter Cantidio- Site Number : 076011, Fortaleza, Ceará
Hospital Geral e Maternidade de Cuiabá- Site Number : 076003, Cuiabá, Mato Grosso
Hospital de Clinicas de Porto Alegre- Site Number : 076008, Porto Alegre, Rio Grande Do Sul
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto- Site Number : 076009, Ribeirão Preto, São Paulo
Instituto Fernandes Figueira - FIOCRUZ- Site Number : 076001, Rio de Janeiro, Not set
Instituto de Genética e Erros Inatos do Metabolismo- Site Number : 076002, São Paulo, Not set
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- Site Number : 076004, São Paulo, Not set
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- Site Number : 076007, São Paulo, Not set
Investigational Site Number : 100001, Sofia, Not set
Investigational Site Number : 124014, Calgary, Alberta
Investigational Site Number : 124002, Edmonton, Alberta
Investigational Site Number : 124010, Vancouver, British Columbia
Investigational Site Number : 124011, Vancouver, British Columbia
Investigational Site Number : 124019, Winnipeg, Manitoba
Investigational Site Number : 124022, Moncton, New Brunswick
Investigational Site Number : 124007, Hamilton, Ontario
Investigational Site Number : 124021, London, Ontario
Investigational Site Number : 124006, Toronto, Ontario
Investigational Site Number : 124004, Montreal, Quebec
Investigational Site Number : 124018, Montreal, Quebec
Investigational Site Number : 124001, Sherbrooke, Quebec
Investigational Site Number : 152002, Punta Arenas, Not set
Investigational Site Number : 152001, Santiago, Not set
Investigational Site Number : 152380, Beijing, Not set
Investigational Site Number : 153202, Beijing, Not set
Investigational Site Number : 153203, Beijing, Not set
Investigational Site Number : 152379, Guangzhou, Not set
Investigational Site Number : 152381, Jinan, Not set
Investigational Site Number : 157250, Jinan, Not set
Investigational Site Number : 152356, Shanghai, Not set
Investigational Site Number : 152382, Shanghai, Not set
Investigational Site Number : 170001, Bogota, Not set
Investigational Site Number : 1910001, Zagreb, Not set
Investigational Site Number : 1910002, Zagreb, Not set
Investigational Site Number : 150809, Praha 2, Not set
Investigational Site Number : 151229, København Ø, Not set
Investigational Site Number : 250010, Bordeaux, Not set
Investigational Site Number : 250012, Brest, Not set
Investigational Site Number : 250003, BRON Cedex, Not set
Investigational Site Number : 250007, BRON Cedex, Not set
Investigational Site Number : 250009, Caen, Not set
Investigational Site Number : 250015, La Tronche, Not set
Investigational Site Number : 250008, Lille, Not set
Investigational Site Number : 250002, Marseille Cedex 05, Not set
Investigational Site Number : 250017, Nancy, Not set
Investigational Site Number : 250019, Nantes, Not set
Investigational Site Number : 250005, Nice, Not set
Investigational Site Number : 250011, Nîmes, Not set
Investigational Site Number : 250004, Paris, Not set
Investigational Site Number : 250001, Paris, Not set
Investigational Site Number : 250018, St Priest en Jarez, Not set
Investigational Site Number : 250016, Strasbourg, Not set
Investigational Site Number : 250014, Toulouse, Not set
Investigational Site Number : 250006, Tours, Not set
Investigational Site Number : 25013, Vannes Cedex, Not set
Investigational Site Number : 152041, Berlin, Not set
Investigational Site Number : 151686, Berlin, Not set
Investigational Site Number : 152293, Berlin, Not set
Investigational Site Number : 152234, Bochum, Not set
Investigational Site Number : 152200, Bonn, Not set
Investigational Site Number : 152108, Freiburg, Not set
Investigational Site Number : 154150, Gießen, Not set
Investigational Site Number : 152045, Halle (Saale), Not set
Investigational Site Number : 154215, Hamburg, Not set
Investigational Site Number : 150031, Mainz, Not set
Investigational Site Number : 152075, München, Not set
Investigational Site Number : 152299, Münster, Not set
Investigational Site Number : 300001, Thessaloniki, Not set
Investigational Site Number : 344001, Kowloon, Not set
Investigational Site Number : 3480009, Debrecen, Not set
Investigational Site Number : 3480007, Nyíregyháza, Not set
Investigational Site Number : 3480011, Pécs, Not set
Investigational Site Number : 356003, Ahmedabad, Not set
Investigational Site Number : 356001, Kolkata, Not set
Investigational Site Number : 3560004, Secunderabad, Not set
Investigational Site Number : 356002, Vellore, Not set
Investigational Site Number : 360001, Jakarta, Not set
Investigational Site Number : 3760002, Beer Sheva, Not set
Investigational Site Number : 3760001, Haifa, Not set
Investigational Site Number : 3760003, Tel Aviv, Not set
Investigational Site Number : 380007, Milan, Milano
Investigational Site Number : 380011, Padua, Padova
Investigational Site Number : 380008, Brescia, Not set
Investigational Site Number : 380006, Cagliari, Not set
Investigational Site Number : 380014, Ferrara, Not set
Investigational Site Number : 380005, Firenze, Not set
Investigational Site Number : 380004, Genova, Not set
Investigational Site Number : 380013, Messina, Not set
Investigational Site Number : 380016, Milano, Not set
Investigational Site Number : 380009, Monza, Not set
Investigational Site Number : 380010, Napoli, Not set
Investigational Site Number : 380019, Napoli, Not set
Investigational Site Number : 380002, Padova, Not set
Investigational Site Number : 380003, Pavia, Not set
Investigational Site Number : 157218, Pisa, Not set
Investigational Site Number : 380015, Roma, Not set
Investigational Site Number : 380012, Roma, Not set
Investigational Site Number : 380017, Torino, Not set
Investigational Site Number : 380001, Udine, Not set
Investigational Site Number : 392106, Sakyo-ku, Kyoto
Investigational Site Number : 392105, Ginowan, Okinawa
Investigational Site Number : 4000001, Amman, Not set
Investigational Site Number : 153178, Yangsan-si, Gyeongsangnam-do
Investigational Site Number : 153180, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 153196, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 153176, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 153191, Daejeon, Not set
Investigational Site Number : 153192, Seoul, Not set
Investigational Site Number : 151149, Seoul, Not set
Investigational Site Number : 153212, Seoul, Not set
Investigational Site Number : 153222, Seoul, Not set
Investigational Site Number : 154225, Kuwait, Not set
Investigational Site Number : 4220004, Beirut, Not set
Investigational Site Number : 458001, Jalan Pahang, Not set
Investigational Site Number : 458002, Kuala Lumpur, Not set
Investigational Site Number : 152029, Rotterdam, Not set
Investigational Site Number : 154264, Karachi, Not set
Investigational Site Number : 154266, Lahore, Not set
Investigational Site Number : 608001, Manila, Not set
Investigational Site Number : 150575, Warszawa, Not set
Investigational Site Number : 620008, Coimbra, Not set
Investigational Site Number : 620006, Lisboa, Not set
Investigational Site Number : 154099, Bucuresti, Not set
Investigational Site Number : 643002, Moscow, Not set
Investigational Site Number : 682004, Makkah, Not set
Investigational Site Number : 682001, Qatif, Not set
Investigational Site Number : 6880001, Belgrade, Not set
Investigational Site Number : 702001, Singapore, Not set
Investigational Site Number : 703001, Bratislava, Not set
Investigational Site Number : 154093, Chiayi, Not set
Investigational Site Number : 152152, Hualian, Not set
Investigational Site Number : 152246, Kaohsiung City, Not set
Investigational Site Number : 152244, Kaohsiung, Not set
Investigational Site Number : 151534, New Taipei City, Not set
Investigational Site Number : 151500, Putz City, Chia-yi, Not set
Investigational Site Number : 151181, Taichung, Not set
Investigational Site Number : 151179, Taichung, Not set
Investigational Site Number : 153248, Tainan City, Not set
Investigational Site Number : 152153, Tainan City, Not set
Investigational Site Number : 151182, Taipei City, Not set
Investigational Site Number : 152226, Taipei City, Not set
Investigational Site Number : 152321, Taipei, Not set
Investigational Site Number : 153158, Taoyuan City, Not set
Investigational Site Number : 764002, Bangkok, Not set
Investigational Site Number : 764003, Bangkok, Not set
Investigational Site Number : 764004, Bangkok, Not set
Investigational Site Number : 764001, Bangkok, Not set
Investigational Site Number : 764005, Khon Kaen, Not set
Investigational Site Number : 7840001, Dubai, Not set
Investigational Site Number : 151340, Cambridge, Cambridgeshire
Investigational Site Number : 152334, Cardiff, Cardiff [Caerdydd Gb-crd]
Investigational Site Number : 152287, Birmingham, England
Investigational Site Number : 151646, London, London, City Of
Investigational Site Number : 150303, London, London, City Of
Investigational Site Number : 150964, Salford, Manchester
Investigational Site Number : 154240, Birmingham, Not set
Investigational Site Number : 152156, Glasgow, Not set
Investigational Site Number : 151123, London, Not set
Investigational Site Number : 150455, Manchester, Not set
Investigational Site Number : 152087, Newcastle, Not set
Investigational Site Number : 154212, Hanoi, Not set
Investigational Site Number : 704002, Ho Chi Minh City, Not set
Conditions: Glycogen Storage Disease Type II, Pompe Disease
CRS Questionnaire Validation Project
Recruiting
The 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel questionnaires designated to measure self-perceived severity and control of Chronic Rhinosinusitis (with or without nasal polyps).
This study will validate translated versions of the same set of questionnaires simultaneously in the centers involved after recruiting a total of 1000 patients, while data collection, statistical analysis, and crea... Read More
The 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel questionnaires designated to measure self-perceived severity and control of Chronic Rhinosinusitis (with or without nasal polyps).
This study will validate translated versions of the same set of questionnaires simultaneously in the centers involved after recruiting a total of 1000 patients, while data collection, statistical analysis, and creation of the study report will be carried out by the statistical department of the University of Leuven.
Patients will be recruited from the regular ENT practice of their hospital to minimize the complexity of the study. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: UCLA Santa Monica Medical Center, Santa Monica, California +31 locations
UCLA Santa Monica Medical Center, Santa Monica, California
Northwestern University Feinberg School of Medicine, Chicago, Illinois
Brigham Sinus Center at Brigham and Women's Hospital, Boston, Massachusetts
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Eastern Virginia Medical School, Virginia, Virginia
UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
St. Michael's Hospital, Toronto, Not set
Univ of Copenhagen, Copenhagen, Not set
HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Not set
Univ Munich, Munich, Not set
University General Hospital of Heraklion, Iraklio, Not set
U. Aristotle, Thessaloniki, Not set
Univ Hospital Roma, Roma, Not set
Univ Amsterdam, Amsterdam, Not set
Alrijne Zorggroep, Leiden, Not set
University of Oradea, Oradea, Not set
Ahmed Alkhadi Hospital, Durban, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Universitario Jerez de La Frontera, Cadiz, Not set
Hospital Universitario Puerta del Mar, Cadiz, Not set
Hospital Universitario Puerto Real, Cadiz, Not set
Hospital de La Línea de La Concepción, Cádiz, Not set
Hospital Clínico Universitario de Compostela, La Coruña, Not set
Hospital Universitario Fuenlabrada, Madrid, Not set
Hospital Universitario Infanta Elena, Madrid y Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital del Bierzo, Ponferrada, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital General Universitario de Valencia, Valencia, Not set
Conditions: Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
Recruiting
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%.
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Research Site, Prescott, Arizona +297 locations
Research Site, Prescott, Arizona
Research Site, Hot Springs National Park, Arkansas
Research Site, Springdale, Arkansas
Research Site, Long Beach, California
Research Site, Palo Alto, California
Research Site, Lone Tree, Colorado
Research Site, Newark, Delaware
Research Site, Fort Myers, Florida
Research Site, Gainesville, Florida
Research Site, Orlando, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tallahassee, Florida
Research Site, West Palm Beach, Florida
Research Site, Fort Wayne, Indiana
Research Site, Indianapolis, Indiana
Research Site, Des Moines, Iowa
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Baton Rouge, Louisiana
Research Site, Marrero, Louisiana
Research Site, Annapolis, Maryland
Research Site, Baltimore, Maryland
Research Site, Baltimore, Maryland
Research Site, Silver Spring, Maryland
Research Site, Towson, Maryland
Research Site, Detroit, Michigan
Research Site, Hattiesburg, Mississippi
Research Site, Grand Island, Nebraska
Research Site, Lincoln, Nebraska
Research Site, Omaha, Nebraska
Research Site, Belleville, New Jersey
Research Site, Albany, New York
Research Site, East Syracuse, New York
Research Site, Fresh Meadows, New York
Research Site, Westbury, New York
Research Site, Cleveland, Ohio
Research Site, Columbus, Ohio
Research Site, Columbus, Ohio
Research Site, Dayton, Ohio
Research Site, Portland, Oregon
Research Site, Horsham, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Memphis, Tennessee
Research Site, Nashville, Tennessee
Research Site, Nashville, Tennessee
Research Site, Houston, Texas
Research Site, Irving, Texas
Research Site, Lancaster, Texas
Research Site, Fairfax, Virginia
Research Site, Henrico, Virginia
Research Site, Tacoma, Washington
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Ciudad de Córdoba, Not set
Research Site, Córdoba, Not set
Research Site, La Plata, Not set
Research Site, La Plata, Not set
Research Site, Rosario, Not set
Research Site, Clayton, Not set
Research Site, Fitzroy, Not set
Research Site, Heidelberg, Not set
Research Site, South Brisbane, Not set
Research Site, Sydney, Not set
Research Site, Linz, Not set
Research Site, Wels, Not set
Research Site, Aalst, Not set
Research Site, Antwerpen, Not set
Research Site, Gent, Not set
Research Site, Barretos, Not set
Research Site, Curitiba, Not set
Research Site, Florianópolis, Not set
Research Site, Fortaleza, Not set
Research Site, Natal, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio De Janeiro, Not set
Research Site, Santa Cruz do Sul, Not set
Research Site, Sao Paulo, Not set
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, Barrie, Ontario
Research Site, Oshawa, Ontario
Research Site, Toronto, Ontario
Research Site, Levis, Quebec
Research Site, Trois-Rivières, Quebec
Research Site, Chicoutimi, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Bengbu, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Fuzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hefei, Not set
Research Site, Hefei, Not set
Research Site, Lanzhou, Not set
Research Site, Linhai, Not set
Research Site, Linyi, Not set
Research Site, Nanchang, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nanning, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenzhen, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Yangzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Olomouc, Not set
Research Site, Ostrava - Vitkovice, Not set
Research Site, Praha, Not set
Research Site, Praha, Not set
Research Site, Angers, Not set
Research Site, Avignon, Not set
Research Site, Bayonne, Not set
Research Site, Bordeaux, Not set
Research Site, Caen, Not set
Research Site, Lille, Not set
Research Site, Limoges, Not set
Research Site, Marseille, Not set
Research Site, Montpellier, Not set
Research Site, Paris Cedex 5, Not set
Research Site, Quimper, Not set
Research Site, Reims, Not set
Research Site, Saint-Malo, Not set
Research Site, Strasbourg Cedex, Not set
Research Site, Suresnes, Not set
Research Site, Toulon Naval, Not set
Research Site, Berlin-Zehlendorf, Not set
Research Site, Bonn, Not set
Research Site, Bonn, Not set
Research Site, Braunschweig, Not set
Research Site, Dresden, Not set
Research Site, Essen, Not set
Research Site, Freiburg, Not set
Research Site, Gauting, Not set
Research Site, Georgsmarienhuette, Not set
Research Site, Gütersloh, Not set
Research Site, Halle, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Immenhausen, Not set
Research Site, Koblenz, Not set
Research Site, Ludwigsburg, Not set
Research Site, Nürnberg, Not set
Research Site, Tuebingen, Not set
Research Site, Velbert, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Deszk, Not set
Research Site, Gyöngyös - Mátraháza, Not set
Research Site, Gyöngyös, Not set
Research Site, Győr, Not set
Research Site, Kecskemét, Not set
Research Site, Pécs, Not set
Research Site, Szekszárd, Not set
Research Site, Székesfehérvár, Not set
Research Site, Törökbálint, Not set
Research Site, Bengaluru, Not set
Research Site, Delhi, Not set
Research Site, Hyderabad, Not set
Research Site, Kolkata, Not set
Research Site, Kolkata, Not set
Research Site, Mysuru, Not set
Research Site, Nagpur, Not set
Research Site, Nashik, Not set
Research Site, New Delhi, Not set
Research Site, Varanasi, Not set
Research Site, Bari, Not set
Research Site, Bergamo, Not set
Research Site, Catanzaro, Not set
Research Site, Milano, Not set
Research Site, Padova, Not set
Research Site, Parma, Not set
Research Site, Pavia, Not set
Research Site, Ravenna, Not set
Research Site, Roma, Not set
Research Site, Roma, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Kawasaki-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sapporo-Shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Ube-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Cheongju-si, Not set
Research Site, Daegu, Not set
Research Site, Incheon, Not set
Research Site, Jinju-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Suwon, Not set
Research Site, Ciudad de México, Not set
Research Site, Ciudad de México, Not set
Research Site, Culiacan, Not set
Research Site, Guadalajara, Not set
Research Site, Guadalajara, Not set
Research Site, Mexico City, Not set
Research Site, Monterrey, Not set
Research Site, Naucalpan, Not set
Research Site, Amsterdam, Not set
Research Site, Groningen, Not set
Research Site, Nieuwegein, Not set
Research Site, Tilburg, Not set
Research Site, Lublin, Not set
Research Site, Olsztyn, Not set
Research Site, Poznań, Not set
Research Site, Przemysl, Not set
Research Site, Radom, Not set
Research Site, Rzeszów, Not set
Research Site, Szklarska Poręba, Not set
Research Site, Tomaszów Mazowiecki, Not set
Research Site, Toruń, Not set
Research Site, Warszawa, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Banska Bystrica, Not set
Research Site, Bratislava, Not set
Research Site, Bratislava, Not set
Research Site, Kosice, Not set
Research Site, Trnava, Not set
Research Site, Amanzimtoti, Not set
Research Site, Bloemfontein, Not set
Research Site, George, Not set
Research Site, Johannesburg, Not set
Research Site, Johannesburg, Not set
Research Site, Pietermaritzburg, Not set
Research Site, Pretoria, Not set
Research Site, Rondebosch, Not set
Research Site, Soweto, Not set
Research Site, Alicante, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Bilbao (Vizcaya), Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Palma, Not set
Research Site, Hsinchu, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, New Taipei, Not set
Research Site, Tainan City, Not set
Research Site, Tainan, Not set
Research Site, Taipei City, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan, Not set
Research Site, Yunlin, Not set
Research Site, Lampang, Not set
Research Site, Muang, Not set
Research Site, Songkhla, Not set
Research Site, Ankara, Not set
Research Site, Antalya, Not set
Research Site, Diyarbakir, Not set
Research Site, Fatih-Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, İzmir, Not set
Research Site, Pamukkale, Not set
Research Site, Çankaya, Not set
Research Site, Birmingham, Not set
Research Site, Blackpool, Not set
Research Site, Bury St Edmunds, Not set
Research Site, Colchester, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Truro, Not set
Conditions: Metastatic Non-small Cell Lung Cancer
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
Recruiting
This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy.
This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Clinical Site, Avondale, Arizona +114 locations
Clinical Site, Avondale, Arizona
Clinical Site, Chandler, Arizona
Clinical Site, Flagstaff, Arizona
Clinical Site, Mesa, Arizona
Clinical Site, Phoenix, Arizona
Clinical Site, Scottsdale, Arizona
Clinical Site, Tucson, Arizona
Clinical Site, Jonesboro, Arkansas
Clinical Site, Pomona, California
Clinical Site, San Diego, California
Clinical Site, Thousand Oaks, California
Clinical Site, Upland, California
Clinical Site, Avon Park, Florida
Clinical Site, Clearwater, Florida
Clinical Site, Hialeah, Florida
Clinical Site, Miami Gardens, Florida
Clinical Site, Tampa, Florida
Clinical Site, Zephyrhills, Florida
Clinical Site, Gainesville, Georgia
Clinical Site, Springfield, Illinois
Clinical Site, Lake Charles, Louisiana
Clinical Site, Grand Blanc, Michigan
Clinical Site, Charlotte, North Carolina
Clinical Site, Leland, North Carolina
Clinical Site, Middleburg Heights, Ohio
Clinical Site, Portland, Oregon
Clinical Site, Duncansville, Pennsylvania
Clinical Site, Jackson, Tennessee
Clinical Site, Memphis, Tennessee
Clinical Site, Murfreesboro, Tennessee
Clinical Site, Allen, Texas
Clinical Site, Austin, Texas
Clinical Site, Baytown, Texas
Clinical Site, Colleyville, Texas
Clinical Site, Houston, Texas
Clinical Site, Lubbock, Texas
Clinical Site, Plano, Texas
Clinical Site, Beckley, West Virginia
Clinical Site, Pleven, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Ruse, Not set
Clinical Site, Sofia, Not set
Clinical Site, Stara Zagora, Not set
Clinical Site, Calgary, Not set
Clinical Site, Trois-Rivières, Not set
Clinical Site, Waterloo, Not set
Clinical Site, Winnipeg, Not set
Clinical Site, Brno, Not set
Clinical Site, Ostrava, Not set
Clinical Site, Studénka, Not set
Clinical Site, Zlín, Not set
Clinical Site, Caluire-et-Cuire, Not set
Clinical Site, Montpellier, Not set
Clinical Site, Narbonne, Not set
Clinical Site, Nice, Not set
Clinical Site, Rouen, Not set
Clinical Site, Tours, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Berlin, Not set
Clinical Site, Berlin, Not set
Clinical Site, Berlin, Not set
Clinical Site, Erlangen, Not set
Clinical Site, Hamburg, Not set
Clinical Site, Herne, Not set
Clinical Site, Muenchen, Not set
Clinical Site, Munich, Not set
Clinical Site, Munich, Not set
Clinical Site, Budapest, Not set
Clinical Site, Budapest, Not set
Clinical Site, Debrecen, Not set
Clinical SIte, Gyula, Not set
Clinical Site, Hódmezővásárhely, Not set
Clinical Site, Nyíregyháza, Not set
Clinical Site, Székesfehérvár, Not set
Clinical Site, Veszprém, Not set
Clinical Site, Białystok, Not set
Clinical Site, Bydgoszcz, Not set
Clinical Site, Częstochowa, Not set
Clinical Site, Elbląg, Not set
Clinical Site, Kraków, Not set
Clinical Site, Kraków, Not set
Clinical Site, Nadarzyn, Not set
Clinical Site, Poznań, Not set
Clinical Site, Poznań, Not set
Clinical Site, Poznań, Not set
Clinical Site, Poznań, Not set
Clinical Site, Sochaczew, Not set
Clinical Site, Warsaw, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Wołomin, Not set
Clinical Site, Wrocław, Not set
Clinical Site, Wrocław, Not set
Clinical Site, Świdnica, Not set
Clinical Site, A Coruña, Not set
Clinical Site, Castellón De La Plana, Not set
Clinical Site, Madrid, Not set
Clinical SIte, Sabadell, Not set
Clinical Site, Santiago De Compostela, Not set
Clinical Site, Santiago De Compostela, Not set
Clinical Site, Sevilla, Not set
Clinical Site, Sevilla, Not set
Clinical Site, Sevilla, Not set
Clinical Site, Barnet, Not set
Clinical Site, Leeds, Not set
Conditions: Arthritis, Psoriatic
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
Recruiting
EFC18418 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study with 3 treatment groups. The purpose of the study is to evaluate the efficacy, safety and tolerability of 2 dosing regimens of itepekimab compared to placebo as add-on therapy to intranasal corticosteroids (INCS) in male and female participants with chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18 years of age and older.
Study details include:
* The study duration per participant (... Read More
EFC18418 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study with 3 treatment groups. The purpose of the study is to evaluate the efficacy, safety and tolerability of 2 dosing regimens of itepekimab compared to placebo as add-on therapy to intranasal corticosteroids (INCS) in male and female participants with chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18 years of age and older.
Study details include:
* The study duration per participant (4-week screening, 52-week treatment, 20-week safety follow-up) will be up to 76 weeks. For participants transitioning to the LTS18420 study, the study duration will be 56 weeks.
* The treatment duration will be up to 52 weeks.
* The number of visits will be 9 site visits and 20 phone/home visits. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Sensa Health- Site Number : 8400038, Los Angeles, California +61 locations
Sensa Health- Site Number : 8400038, Los Angeles, California
Newport Native MD- Site Number : 8400031, Newport Beach, California
Breathe Clear Institute for Sinus and Allergy Relief- Site Number : 8400040, Torrance, California
Orso Health- Site Number : 8400035, Torrance, California
Advanced Research Associates (ARA) Professionals- Site Number : 8400011, Miami, Florida
Paradisus Med Research- Site Number : 8400009, Miami, Florida
Orlando ENT & Allergy- Site Number : 8400008, Orlando, Florida
Emory University- Site Number : 8400047, Atlanta, Georgia
North Shore University Hospital- Site Number : 8400028, Manhasset, New York
Ten20 Clinical Research- Site Number : 8400015, Dallas, Texas
Investigational Site Number : 0320004, Rosario, Santa Fe
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320003, Mendoza, Not set
Investigational Site Number : 0400005, Graz, Not set
Investigational Site Number : 1240002, Montreal, Quebec
Investigational Site Number : 1240001, Québec City, Quebec
Investigational Site Number : 1520006, Valdivia, Los Ríos
Investigational Site Number : 1520003, Talca, Maule
Investigational Site Number : 1520002, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520004, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 2460003, Helsinki, Not set
Investigational Site Number : 2460004, Helsinki, Not set
Investigational Site Number : 2460002, Kuopio, Not set
Investigational Site Number : 2760003, Wuerzburg, Not set
Investigational Site Number : 3480002, Budapest, Not set
Investigational Site Number : 3480001, Pecs, Not set
Investigational Site Number : 3760007, Haifa, Not set
Investigational Site Number : 3760005, Petah Tikva, Not set
Investigational Site Number : 3760009, Tel Aviv, Not set
Investigational Site Number : 3800006, Milan, Milano
Investigational Site Number : 3800008, Padua, Padova
Investigational Site Number : 3800002, Rome, Roma
Investigational Site Number : 3920002, Odawara, Kanagawa
Investigational Site Number : 3920006, Fukui, Not set
Investigational Site Number : 3920003, Kumamoto, Not set
Investigational Site Number : 4100005, Cheonan-si, Chungcheongnam-do
Investigational Site Number : 4100003, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100004, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100002, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100001, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 5280004, Alkmaar, Not set
Investigational Site Number : 5280002, Leiderdorp, Not set
Investigational Site Number : 6160001, Wroclaw, Dolnoslaskie
Investigational Site Number : 6160002, Warsaw, Mazowieckie
Investigational Site Number : 6160003, Bialystok, Not set
Investigational Site Number : 6160004, Wroclaw, Not set
Investigational Site Number : 6200003, Guimaraes, Not set
Investigational Site Number : 6200004, Matosinhos, Not set
Investigational Site Number : 6200002, Porto, Not set
Investigational Site Number : 7240003, Santiago de Compostela, A Coruña [La Coruña]
Investigational Site Number : 7240002, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 7240004, Jerez de La Frontera, Cádiz
Investigational Site Number : 7240001, Majadahonda, Madrid
Investigational Site Number : 7240006, Seville, Sevilla
Investigational Site Number : 7240005, Zaragoza, Not set
Investigational Site Number : 7520002, Lund, Not set
Investigational Site Number : 7920003, Ankara, Not set
Investigational Site Number : 8260002, London, London, City Of
Investigational Site Number : 8260006, Oxford, Oxfordshire
Investigational Site Number : 8260004, Bradford, Not set
Investigational Site Number : 8260001, Newcastle Upon Tyne, Not set
Conditions: Chronic Rhinosinusitis With Nasal Polyps
A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 1)
Recruiting
This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6.
This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC.
Study details include:
The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Dermatology Research Associates - Los Angeles- Site Number : 8400004, Los Angeles, California +56 locations
Dermatology Research Associates - Los Angeles- Site Number : 8400004, Los Angeles, California
Michigan Center for Research Company- Site Number : 8400013, Clarkston, Michigan
Equity Medical- Site Number : 8400017, New York, New York
Red River Research Partners - Fargo- Site Number : 8400007, Fargo, North Dakota
MedCare Pharma - Houston - Cypress Creek Parkway- Site Number : 8400014, Houston, Texas
Care Access - Arlington- Site Number : 8400022, Arlington, Virginia
Investigational Site Number : 0320003, Rosario, Santa Fe
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320004, Buenos Aires, Not set
Investigational Site Number : 0320002, Mendoza, Not set
Investigational Site Number : 1240005, Edmonton, Alberta
Investigational Site Number : 1240001, London, Ontario
Investigational Site Number : 1240007, Mississauga, Ontario
Investigational Site Number : 1240009, Montreal, Quebec
Investigational Site Number : 1240008, Québec City, Quebec
Investigational Site Number : 1240010, Regina, Saskatchewan
Investigational Site Number : 1240002, Saskatoon, Saskatchewan
Investigational Site Number : 1520002, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520003, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1560002, Beijing, Not set
Investigational Site Number : 1560004, Hangzhou, Not set
Investigational Site Number : 1560001, Shanghai, Not set
Investigational Site Number : 1560003, Shijiazhuang, Not set
Investigational Site Number : 1560005, Suzhou, Not set
Investigational Site Number : 2030001, Ostrava, Not set
Investigational Site Number : 2760003, Bad Bentheim, Not set
Investigational Site Number : 2760002, Lübeck, Not set
Investigational Site Number : 2760001, Magdeburg, Not set
Investigational Site Number : 3000001, Athens, Not set
Investigational Site Number : 3000002, Thessaloniki, Not set
Investigational Site Number : 3000003, Thessaloniki, Not set
Investigational Site Number : 3480001, Debrecen, Not set
Investigational Site Number : 3480002, Kaposvár, Not set
Investigational Site Number : 3800001, Rome, Roma
Investigational Site Number : 3800002, Bologna, Not set
Investigational Site Number : 3920002, Ebina-shi, Kanagawa
Investigational Site Number : 3920001, Kamiamakusa, Kumamoto
Investigational Site Number : 3920007, Sakai, Osaka
Investigational Site Number : 3920003, Tachikawa, Tokyo
Investigational Site Number : 3920009, Fukuoka, Not set
Investigational Site Number : 3920005, Kagoshima, Not set
Investigational Site Number : 4840001, Chihuahua, Not set
Investigational Site Number : 6200002, Coimbra, Not set
Investigational Site Number : 6200003, Lisbon, Not set
Investigational Site Number : 6200001, Porto, Not set
Investigational Site Number : 7240003, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240005, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 7240002, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 7240004, Valencia, Not set
Investigational Site Number : 1580002, Kaohsiung City, Not set
Investigational Site Number : 1580001, Taipei City, Not set
Investigational Site Number : 7920003, Adapazari, Not set
Investigational Site Number : 7920002, Istanbul, Not set
Investigational Site Number : 7920001, Samsun, Not set
Investigational Site Number : 8260002, Milton Keynes, Buckinghamshire
Investigational Site Number : 8260001, London, England
Conditions: Lichen Simplex Chronicus
A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease
Recruiting
This is a study where a new drug, called GSK4771261 is being tested. Neither the study doctors, study staff or participants will be aware of what treatment is being given. Part A is testing the new study treatment on healthy people. This is to see if it's safe, what it does to the body, and how the body's defense system responds to it. Part B is similar, but the study treatment will be given to people who have a kidney disease called autosomal dominant polycystic kidney disease (ADPKD).
This is a study where a new drug, called GSK4771261 is being tested. Neither the study doctors, study staff or participants will be aware of what treatment is being given. Part A is testing the new study treatment on healthy people. This is to see if it's safe, what it does to the body, and how the body's defense system responds to it. Part B is similar, but the study treatment will be given to people who have a kidney disease called autosomal dominant polycystic kidney disease (ADPKD). Read Less
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
08/06/2025
Locations: GSK Investigational Site, Bruxelles, Not set +13 locations
GSK Investigational Site, Bruxelles, Not set
GSK Investigational Site, Leuven, Not set
GSK Investigational Site, London, Ontario
GSK Investigational Site, MontrEal, Quebec
GSK Investigational Site, Brest, Not set
GSK Investigational Site, Koeln, Nordrhein- Westfalen
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Cambridge, Not set
GSK Investigational Site, Exeter, Not set
GSK Investigational Site, London, Not set
GSK Investigational Site, Newcastle Upon Tyne, Not set
Conditions: Kidney Disease
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
Recruiting
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood... Read More
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can help improve kidney function by reducing the activity of the renin-angiotensin-aldosterone system (RAAS). The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can impair the ability of the kidneys to work properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system.
The study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB.
So, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function.
The main purpose of this study is to learn how safe the treatment is when used of finerenone in addition to an ACEI or ARB in long-term.
To see how safe the treatment is, the study team will collect information on medical problems which are also known as "treatment emergent adverse events" (TEAEs). And they will also collect levels of an electrolyte called potassium in the blood by taking blood samples, and measure blood pressure during the study.
The secondary purpose of this study is to learn how well long-term use of finerenone can reduce the amount of protein in the participants' urine and benefit kidney function when taken with standard of care.
To see how the treatment works, the study team will collect participants' urine samples to assess urinary albumin-to-creatinine ratio (UACR) and urinary protein-to-creatinine ratio (UPCR), which are important assessments for calculating the level of protein in the urine. Researchers will also collect blood samples to analyze serum creatinine and calculate estimated glomerular filtration rate (eGFR). A significant decline in eGFR indicates worsening kidney function.
The study will include participants who had previously participated in FIONA study (NCT05196035). The participants will be aged from 1 year up to 18 years.
The participants will be in the study for approximately 19 months. They will take study treatment for up to 18 months and will be follow up for 1 month. During this period, at least 12 visits are planned for patients who newly start finerenone, and at least 8 visits for patients who already received finerenone.
In the visit, the study team will:
* have their blood pressure, heart rate, temperature, height and weight measured
* have blood and urine samples taken
* have physical examinations
* have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart)
* answer questions about their medication and whether they have any adverse events, or have their parents or guardian's answer
* answer questions about how they are feeling, or have their parents or guardian's answer
* answer question about how they like the study medication, or have their parents or guardian's answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.
The doctors will check the participants' health about 30 days after the participants take their last treatment. Read Less
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
08/06/2025
Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona +164 locations
Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona
Cedars-Sinai Samuel Oschin Cancer Center, Los Angeles, California
Lucille Packard Children's Hospital Stanford - Pediatric Nephrology, Palo Alto, California
Rady Children's Hospital San Diego - Cardiology, San Diego, California
Children's National Medical Center - Nephrology, Washington, District of Columbia
Memorial Transplant Institute - Pediatric Nephrology, Hollywood, Florida
Emory University Hospital/Children's Healthcare of Atlanta - Nephrology, Atlanta, Georgia
University of Iowa Health Care Medical Center - Nephrology, Iowa City, Iowa
The Charlotte R. Bloomberg Children's Center Building - Nephrology, Baltimore, Maryland
Boston Children's Hospital - Main Campus - Nephrology, Boston, Massachusetts
Children's Mercy Hospital Kansas City - Nephrology, Kansas City, Missouri
Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension, Cincinnati, Ohio
Cleveland Clinic | Pediatric Nephrology, Cleveland, Ohio
OHSU Doernbecher Children's Hospital - Neurology, Portland, Oregon
Children's Hospital of Philadelphia - Nephrology, Philadelphia, Pennsylvania
University Hospital - San Antonio - Pediatric Nephrology, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
Seattle Children's Hospital - Nephrology, Seattle, Washington
Hospital de Niños Sor María Ludovica, La Plata, Buenos Aires
Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department, Ciudad Autonoma de Buenos Aire, Ciudad Auton. De Buenos Aires
Centro de Rehabilitacion Cardiovascular | San Luis, Argentina, San Luis, Provincia De San Luis
Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina, Santa Fe, Provincia De Santa Fe
Hospital Italiano de Buenos Aires, Buenos Aires, Not set
Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Not set
Hospital General de Ninos Pedro de Elizalde | Nephrology Department, Ciudad Autonoma de Buenos Aire, Not set
Many Locations, Multiple Locations, Not set
Queensland Children's Hospital, South Brisbane, Queensland
Monash Children's Hospital, Clayton, Victoria
Royal Children's Hospital Melbourne, Parkville, Victoria
Kepler Universitätsklinikum Campus IV, Linz, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Many Locations, Multiple Locations, Not set
Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, Not set
Universitätsklinikum AKH Wien, Wien, Not set
Huderf / Ukzkf, Bruxelles - Brussel, Not set
CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel, Not set
UZ Gent, Gent, Not set
UZ Gasthuisberg - Pediatric Nephrology, Leuven, Not set
CHC Montlégia - Pediatrics, Liège, Not set
Many Locations, Multiple Locations, Not set
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais
Hospital Pequeno Principe, Curitiba, Parana
Hosp Clínicas Facult. Med. de Ribeirão Preto / USP, Ribeirão Preto/SP, Sao Paulo
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas, São Paulo, Sao Paulo
Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil, Sao Paulo, SP
Instituto da Crianca e do Adolescente, Sao Paulo, Not set
UMHAT Sveti Georgi, Plovdiv, Not set
SHATPD "Prof. Ivan Mitev", Sofia, Not set
MHAT prof. Stoyan Kirkovitch AD, Stara Zagora, Not set
Alberta Children's Hospital - Nephrology Clinic, Calgary, Alberta
The Hospital for Sick Children (SickKids), Toronto, Ontario
CHU Sainte-Justine, Montreal, Quebec
Many Locations, Multiple Locations, Not set
Všeobecná fakultní nemocnice v Praze, Praha 2, Not set
Fakultní nemocnice v Motole, Praha 5, Not set
Rigshospitalet - Børn og Unge, Copenhagen, Not set
Many Locations, Multiple Locations, Not set
Odense Universitetshospital - HC Andersen Børne og Ungehospital, Odense C, Not set
Aarhus Universitetshospital - Børn og Unge, Århus N, Not set
Helsinki University Hospital | Children's Hospital - Clinical Trial Unit, Nephrology Department, Helsinki, Not set
Many Locations, Multiple Locations, Not set
Tays Service Centre | Tampere University Hospital - Pediatric Early Phase Clinical Trials Unit, Tampere, Not set
Turun yliopistollinen keskussairaala, Turku, Not set
CHU bordeaux - Hopital Pellegrin, BORDEAUX cedex, Not set
CHU de Lyon - Hopital Femme Mère Enfant, Bron, Not set
Hopital Arnaud de Villeneuve CHU Montpellier, Montpellier, Not set
Many Locations, Multiple Locations, Not set
Hopital Robert Debre, Paris, Not set
CHU Strasbourg - Hopital Hautepierre, Strasbourg, Not set
Hôpital des Enfants, TOULOUSE Cedex 9, Not set
Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg
Universitätsklinikum Erlangen, Erlangen, Bayern
Medizinische Hochschule Hannover (MHH) | Zentrum Innere Medizin | Klinik fuer Kardiologie und Angiologie, Hannover, Niedersachsen
Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen
Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen
Universitätsklinikum Essen, Essen, Nordrhein-Westfalen
Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen
Charité / Pädiatrie, Berlin, Not set
Universitätsklinikum Hamburg Eppendorf (UKE), Hamburg, Not set
Many Locations, Multiple Locations, Not set
Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department, Athens, Not set
Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department, Athens, Not set
University General Hospital of Heraklion - Department of Paediatrics, Heraklion, Not set
Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit, Ioannina, Not set
Many Locations, Multiple Locations, Not set
Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit', Thessaloniki, Not set
Semmelweis University, Budapest, Not set
Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set
Many Locations, Multiple Locations, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set
SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont, Szeged, Not set
All India Institute of Medical Sciences (AIIMS) - New Delhi, Delhi, Not set
NRS Medical college, Kolkata, Not set
Clalit Health | Soroka Medical Center - Internal Medicine Department, Beer Sheva, Not set
Wilf Children's Hospital Shaare Zedek Medical Center, Jerusalem, Not set
Many Locations, Multiple Locations, Not set
Health Corporation of Galilee Medical Center, Nahariya, Not set
Clalit Health Services Schneider Children's Medical Center, Petach Tikva, Not set
Dana-Dwek Children's Hospital, Tel Aviv, Not set
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria, Bologna, Emilia-Romagna
Ospedale Pediatrico Bambino Gesù - Nefrologia, Roma, Lazio
IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene, Genova, Liguria
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene, Milano, Lombardia
Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi, Firenze, Not set
Many Locations, Multiple Locations, Not set
A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica, Torino, Not set
Kyungpook National University Hospital, Daegu, Daegu Gwang''yeogsi
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggido
Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnamdo
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Many Locations, Multiple Locations, Not set
Korea University Guro Hospital, Seoul, Not set
Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas, Not set
Klaipeda Children's Hospital, Klaipeda, Not set
Many Locations, Multiple Locations, Not set
Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre, Vilnius, Not set
Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan
Sitio Alfredo Chew Wong | Aguascalientes, Mexico, Aguascalientes, Agguascalientes
Hospital Infantil de México "Dr. Federico Gómez", México D.F., Distrito Federal
Instituto Nacional de Pediatría, México, D.F., Distrito Federal
Hospital Universitario "José Eleuterio González", Monterrey, Nuevo Leon
Instituto Veracruzano en Investigación Clinica SC, Veracruz, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Many Locations, Multiple Locations, Not set
University Medical Center Utrecht, Utrecht, Not set
Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
Many Locations, Multiple Locations, Not set
Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Not set
Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu, Wroclaw, Not set
Hospital Santa Maria | Centro de Investigacao Clinica, Missing, Lisboa
Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set
Hospital Pediátrico de Coimbra I ULS Coimbra, Coimbra, Not set
Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica, Porto, Not set
Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set
Hospital de Sant Joan de Déu, Barcelona, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital la Paz, Madrid, Not set
Many Locations, Multiple Locations, Not set
Hospital Universitario Regional De Malaga - Nefrologia pediatrica, Málaga, Not set
Hospital Universitario Virgen Del Rocio S.L. - Nefrologia pediatrica, Sevilla, Not set
Skåne University Hospital, Lund, Not set
Many Locations, Multiple Locations, Not set
Karolinska University Hospital, Stockholm, Not set
Uppsala University Hospital, Uppsala, Not set
Universitäts-Kinderspital UKBB, Basel, Basel-Stadt
Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud
Hopital des Enfants HUG, Geneva, Not set
Many Locations, Multiple Locations, Not set
Hacettepe Universitesi Tip Fakultesi, Ankara, Not set
Baskent Universitesi Tip Fakultesi Hastanesi, Ankara, Not set
Gazi Universitesi Tip Fakultesi, Ankara, Not set
Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara, Not set
Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics, Istanbul, Not set
Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi, Istanbul, Not set
Marmara University Medical Faculty | Pediatric Nephrology, Istanbul, Not set
Many Locations, Multiple Locations, Not set
NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility, Glasgow, Stratchclyde
Birmingham Children's Hospital, Birmingham, West Midlands
Great Ormond Street Hospital for Children, London, Not set
Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility, Manchester, Not set
Many Locations, Multiple Locations, Not set
Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility, Nottingham, Not set
Conditions: Chronic Kidney Disease, Proteinuria, Children
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
Recruiting
This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis
This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis Read Less
Gender:
ALL
Ages:
Between 12 years and 100 years
Trial Updated:
08/06/2025
Locations: Childrens Hospital Colorado, Aurora, Colorado +43 locations
Childrens Hospital Colorado, Aurora, Colorado
Georgia Nephrology Research Inst, Lawrenceville, Georgia
University of Iowa Health Care, Iowa City, Iowa
Col Uni Med Center New York Presby, New York, New York
Novartis Investigative Site, Buenos Aires, Not set
Novartis Investigative Site, Belo Horizonte, MG
Novartis Investigative Site, Porto Alegre, RS
Novartis Investigative Site, Botucatu, Sao Paulo
Novartis Investigative Site, Sao Paulo, SP
Novartis Investigative Site, Toronto, Ontario
Novartis Investigative Site, Beijing, Not set
Novartis Investigative Site, Shanghai, Not set
Novartis Investigative Site, Praha 2, Not set
Novartis Investigative Site, Montpellier 5, Not set
Novartis Investigative Site, Paris 15, Not set
Novartis Investigative Site, Paris, Not set
Novartis Investigative Site, Toulouse, Not set
Novartis Investigative Site, Erlangen, Not set
Novartis Investigative Site, Essen, Not set
Novartis Investigative Site, Hamburg, Not set
Novartis Investigative Site, Mainz, Not set
Novartis Investigative Site, Heraklion Crete, Not set
Novartis Investigative Site, Petach Tikva, Not set
Novartis Investigative Site, Petach-Tikva, Not set
Novartis Investigative Site, Ranica, BG
Novartis Investigative Site, Roma, RM
Novartis Investigative Site, Nagoya, Aichi
Novartis Investigative Site, Asahikawa, Hokkaido
Novartis Investigative Site, Sapporo, Hokkaido
Novartis Investigative Site, Takatsuki, Osaka
Novartis Investigative Site, Ohtsu, Shiga
Novartis Investigative Site, Niigata, Not set
Novartis Investigative Site, Leiden, Zuid Holland
Novartis Investigative Site, Sevilla, Andalucia
Novartis Investigative Site, Barcelona, Catalunya
Novartis Investigative Site, Pamplona, Navarra
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Bern, Not set
Novartis Investigative Site, Ankara, Not set
Novartis Investigative Site, Kocaeli, Not set
Novartis Investigative Site, Talas Kayseri, Not set
Novartis Investigative Site, London, Not set
Novartis Investigative Site, Newcastle upon Tyne, Not set
Conditions: C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
Recruiting
This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC).
This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Highlands Oncology Group, Springdale, Arkansas +229 locations
Highlands Oncology Group, Springdale, Arkansas
Clinical Research Providence Medical Foundation, Fullerton, California
UCLA Hematology-Oncology, Los Angeles, California
UCSF Mission Bay Mission Hall, San Francisco, California
University of Miami Hospital and Clinics Sylvester Comprehensive Cancer Center, Miami, Florida
AdventHealth Orlando, Cancer Institute, Orlando, Florida
H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa, Florida
Rush University Medical Center, Chicago, Illinois
Baptist Health Lexington, Lexington, Kentucky
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
John Hopkins School of Medicine, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
Henry Ford Health System, Detroit, Michigan
Mercy Clinic Oncology and Hematology Sindelar Cancer Center, Saint Louis, Missouri
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Astera Cancer Care, East Brunswick, New Jersey
Meridian Health Systems, Neptune, New Jersey
Montefiore Medical Center Prime, Bronx, New York
Clinical Research Alliance, Inc, Lake Success, New York
New York University Cancer Center - Laura and Isaac, New York, New York
Cleveland Clinic Mercy Hospital, Canton, Ohio
Oncology/Hematology Care Clinical Trials, Llc, Cincinnati, Ohio
Providence Portland Medical Center, Portland, Oregon
THE WEST CLINIC, PLLC dba West Cancer Center, Germantown, Tennessee
Houston Methodist Cancer Center, Houston, Texas
University of Texas Md Anderson Cancer Center, Houston, Texas
Texas Oncology, P.A. - Tyler, Tyler, Texas
Medical College of Wisconsin, Milwaukee, Wisconsin
Ballarat Base Hospital, Ballarat, Not set
Flinders Medical Centre (Fmc), Bedford Park, Not set
Chris O Brien Lifehouse, Camperdown, Not set
Sunshine Hospital, St Albans, Not set
St John of God Subiaco Hospital, Subiaco, Not set
Townsville Cancer Centre, Townsville, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Landeskrankenhaus Feldkirch, Feldkirch, Not set
Landesklinikum Krems, Krems, Not set
Kepler University Hospital, Linz, Not set
Wiener Gesundheitsverband Klinik Penzing, Wien, Not set
Klinik Floridsdorf, Wien, Not set
Cliniques Universitaires Saint-Luc, Bruxelles, Not set
UZA, Edegem, Not set
Jessa Ziekenhuis Hospital, Hasselt, Not set
Centre Hospitalier Universitaire de Liege, Liege, Not set
AZ DELTA, Roeselare, Not set
Chu Ucl Namur, Yvoir, Not set
Departmento de Pesquisa Clinica- Hospital de Amor de Barretos, Barretos, Not set
Cepon - Centro de Pesquisas Oncolăgicas de Santa Catarina, FlorianĂłpolis, Not set
Clínica de Neoplasias Litoral, ItajaĂ-, Not set
Hospital São Lucas Da Pucrs, Porto Alegre, Not set
Cepho Centro de Estudos E Pesquisas de Hematologia E Oncologia, Santo Andre, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, Sao Jose Rio Preto, Not set
ICESP Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, São Paulo, Not set
Hospital Benefică Ncia Portuguesa de Să O Paulo, São Paulo, Not set
Hospital Alemão Oswaldo Cruz, São Paulo, Not set
Hospital Sirio-Libanes, SĂŁo Paulo, Not set
A. C. Camargo Cancer Center, SĂŁo Paulo, Not set
William Osler Health System - Brampton Civic Hospital, Brampton, Not set
Cross Cancer Institute, Edmonton, Not set
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec City, Not set
Princess Margaret Cancer Center, Toronto, Not set
Cancercare Manitoba, Winnipeg, Not set
China-Japan Friendship Hospital, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Beijing Chest Hospital,Capital Medical University, Beijing, Not set
Jilin Province Tumor Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
West China Hospital, Sichuan University, Chengdu Shi, Not set
Sichuan Cancer Hospital, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Harbin Medical University Cancer Hospital, Haerbin, Not set
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
The Second Affiliated Hospital of Nanchang University, Jiangxi, Not set
Shandong Cancer Hospital, Jinan, Not set
Linyi Cancer Hospital, Linyi, Not set
The Second Peoples Hospital of Neijiang, Neijiang, Not set
Yantai Yuhuangding Hospital, Shandong, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Liaoning Cancer Hospital & Institute, Shenyang, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, Not set
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Not set
Huazhong University of Science and Technology - Tongji Medical College - Tongji Hospital Tjh, Wuhan, Not set
Hubei Cancer Hospital, Wuhan, Not set
The First Affiliated Hospital of Xiân Jiaotong University, Xi'an, Not set
Xiangyang Central Hospital, Xiangyang, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Krajska Nemocnice Liberec A.S., Liberec, Not set
Fakultni Nemocnice Olomouc, Olomouc, Not set
Fakultni Thomayerova Nemocnice, Praha 4, Not set
Institut Sainte Catherine, Avignon, Not set
Chu Bordeaux, Bordeaux cedex, Not set
Centre Hospitalier Intercommunal de Cră Teil, Creteil Cedex, Not set
Institut Cœur Poumon CHU de Lille, Lille, Not set
Chu Limoges - Hopital Du Cluzeau, Limoges cedex, Not set
Centre Léon Bérard, Lyon, Not set
Assistance Publique-Hă"Pitaux de Marseille, Marseille, Not set
Hopital Arnaud de Villeneuve, Montpellier cedex 05, Not set
Institut Régional Du Cancer de Montpellier, Montpellier, Not set
Ch de Mulhouse - Hă"Pital Emile Muller, Mulhouse Cedex, Not set
Institut Curie - Site de Paris, Paris Cedex 05, Not set
Hopital Tenon, Paris, Not set
Chu Rennes - Hopital Pontchaillou, Rennes cedex 09, Not set
Chu Nantes - Hă"Pital Guillaume Et Renă Laă<Nnec, Saint Herblain, Not set
Institut de Cancerologie de La Loire, Saint-Priest-En-Jarez, Not set
Hă"Pital Foch, Suresnes Cedex, Not set
Institut Gustave Roussy, Villejuif, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Helios Klinikum Erfurt, Erfurt, Not set
Universtitaetsklinikum Essen, Essen, Not set
Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt am Main, Not set
Krankenhaus Nordwest Gmbh, Frankfurt, Not set
Asklepios Fachkliniken Muenchen-Gauting, Gauting, Not set
Srh Wald-Klinikum Gera Gmbh, Gera, Not set
UNIVERSITATSKLINIKUM GIeBEN UND MARBURG GMBH, Giessen, Not set
Asklepios Klinik Harburg, Hamburg, Not set
Lki Lungenfachklinik Immenhausen, Immenhausen/Krs. Kassel, Not set
Staedtisches Krankenhaus Kiel, Kiel, Not set
Johannes Wesling Klinikum Minden, Minden, Not set
Pius-Hospital Oldenburg, Oldenburg, Not set
Universitaetsklinikum Ulm, Ulm, Not set
'Henry Dynant' Hospital Center, Athens, Not set
General Hospital of Athens of Chest Diseases 'Sotiria', Athens, Not set
General Hospital of Athens Alexandra, Athens, Not set
University General Hospital "Attikon", Chaidari, Not set
University General Hospital of Larissa, Larisa, Not set
General Hospital of Patra Agios Andreas, Patra, Not set
Metropolitan Hospital, Piraeus, Not set
St Luke'S Hospital, Thessaloniki, Not set
Semmelweis Egyetem, Budapest, Not set
Orszagos Koranyi Pulmonologiai Intezet, Budapest, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz, Gyor, Not set
Bács-Kiskun Vármegyei Oktatókórház, Kecskemet, Not set
Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari, Bari, Not set
Humanitas Gavazzeni, Bergamo, Not set
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili), Brescia, Not set
Azienda Ospedaliera Universitaria Policlinico - Vittorio Emanuele (Presidio Gaspare Rodolico), Catania, Not set
Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Not set
Istituto Nazionale Per La Ricerca Sul Cancro Di Genova, Genova, Not set
Ospedale San Raffaele, Milano, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set
IEO Istituto Europeo di Oncologia, Milano, Not set
Azienda Socio Sanitaria Territoriale Di Monza (Presidio San Gerardo), Monza, Not set
Azienda Ospedaliera Universitaria- Universită Degli Studi Della Campania  Luigi Vanvitelliâ, Napoli, Not set
Azienda Ospedaliero Universitaria Di Parma, Parma, Not set
Azienda Ospedaliera Di Perugia Ospedale S. Maria Della Misericordia, Perugia, Not set
Istituto Nazionale Tumori Regina Elena Irccs, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Centro Ricerche Cliniche Di Verona S.R.L., Verona, Not set
National Cancer Center Hospital, Chuo-ku, Not set
Kyushu University Hospital, Fukuoka, Not set
Kansai Medical University Hospital, Hirakata-shi, Not set
National Cancer Center Hospital East, Kashiwa, Not set
The Cancer Institute Hospital of Jfcr, Koto-ku, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Not set
Okayama University Hospital, Okayama, Not set
Kindai University Hospital, Osaka-Sayama, Not set
Kitasato University Hospital, Sagamihara, Not set
National Hospital Organization Hokkaido Cancer Center, Sapporo, Not set
Shizuoka Cancer Center, Sunto-gun, Not set
Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Chungbuk National University Hospital, Cheongju, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
The Catholic University of Korea, St. Vincent'S Hospital, Suwon-si, Not set
Ajou University Hospital, Suwon, Not set
Netherlands Cancer Institute, Amsterdam, Not set
Maastricht University Medical Center, Maastricht, Not set
Jeroen Bosch Ziekenhuis, s Hertogenbosch, Not set
Etz Elisabeth, Tilburg, Not set
Centrum Onkologii Im. Prof. F. Lukaszczyka W Bydgoszczy, Bydgoszcz, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy, Otwock, Not set
Szpital Specjalistyczny W Prabutach, Prabuty, Not set
Provita Prolife, Tomaszow Mazowiecki, Not set
Centro Hospitalar E Universită Rio de Coimbra E.P.E., Coimbra, Not set
Hospital Da Senhora Da Oliveira Guimară Es, Guimarães, Not set
Hospital Da Luz, Lisboa, Not set
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital Pulido Valente, Lisboa, Not set
Centro Hospitalar Do Porto, E.P.E. - Hospital de Santo António, Porto, Not set
Institutul Oncologic 'Prof. Dr. Ion Chiricuta' Cluj Napoca, Cluj Napoca, Not set
S.C Radiotherapy Center Cluj S.R.L, Comuna Floresti, Not set
S.C Centrul de Oncologie Sfantul Nectarie Craiova, Craiova, Not set
S.C. Sigmedical Services Srl, Suceava, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de La Santa Creu I Sant Pau, Barcelona, Not set
Hospital Universitari Vall D'Hebron, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitario Ciudad de Jaen, Jaen, Not set
Hospital de Especialidades de Jerez de La Frontera, Jerez De Frontera, Not set
Ico L'Hospitalet - Hospital Duran I Reynals, L'Hospitalet de Llobregat, Not set
Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario Ramon Y Cajal, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Malaga, Malaga, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Universitario Nuestra Señora de Valme, Sevilla, Not set
Inselspital - Universitaetsspital Bern, Bern, Not set
Kantonsspital St. Gallen, St. Gallen, Not set
Hfr Fribourg/Kantonsspital Fribourg, Villars-sur-Glâne, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospitalx, Tainan, Not set
National Taiwan University Cancer Centre, Taipei, Not set
Taipei Medical University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital, Taoyuan County, Not set
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Dicle University, Medical Faculty, Diyarbakir, Not set
Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul, Not set
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul, Not set
Medipol University Medical Faculty, Istanbul, Not set
Izmir Medicalpark Hospital, Izmir, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
St James'S University Hospital, Leeds, Not set
Churchill Hospital, Oxford, Not set
Conditions: Small Cell Lung Cancer
A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors
Recruiting
This clinical trial is studying solid tumor cancers. A solid tumor is one that starts in part of your body like your lungs or liver instead of your blood. Once they've grown bigger in one spot or spread to other parts of the body, they're harder to treat. This is called advanced or metastatic cancer.
Participants in this study must have breast cancer or gastric cancer. Participants must have tumors that have HER2 on them. This allows the cancer to grow more quickly or spread faster. There are f... Read More
This clinical trial is studying solid tumor cancers. A solid tumor is one that starts in part of your body like your lungs or liver instead of your blood. Once they've grown bigger in one spot or spread to other parts of the body, they're harder to treat. This is called advanced or metastatic cancer.
Participants in this study must have breast cancer or gastric cancer. Participants must have tumors that have HER2 on them. This allows the cancer to grow more quickly or spread faster. There are few treatment options for patients with advanced or metastatic solid tumors that express HER2.
This clinical trial uses an experimental drug called disitamab vedotin (DV). Disitamab vedotin is a type of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them.
This clinical trial uses a drug called tucatinib, which has been approved to treat cancer in the United States and some other countries. This drug is sold under the brand name TUKYSA®.
This study will test how safe and how well DV with tucatinib works for participants with solid tumors. This study will also test what side effects happen when participants take these drugs. A side effect is anything a drug does to the body besides treating the disease. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Banner-University Medical Center Tucson Campus, Tucson, Arizona +122 locations
Banner-University Medical Center Tucson Campus, Tucson, Arizona
Banner-University Medical Center Tucson Campus, Tucson, Arizona
Banner-University Medical Center Tucson, Tucson, Arizona
The University of Arizona Cancer Center-North Campus Pharmacy, Attn: Kelly Myrdal, Tucson, Arizona
University of Arizona Cancer Center - North Campus, Tucson, Arizona
The University of Arizona Cancer Center-Main, Tucson, Arizona
UC Irvine Medical Center, Orange, California
University of California, San Francisco | HDFCCC - Hematopoietic Malignancies, San Francisco, California
UCLA Department of Medicine - Hematology & Oncology, Santa Monica, California
Colorado West Healthcare System, dba Community Hospital, Grand Junction, Colorado
Colorado West Healthcare, dba Grand Valley Oncology, Grand Junction, Colorado
Danbury Hospital, Danbury, Connecticut
The Whittingham Cancer Center / Norwalk Hospital, Norwalk, Connecticut
Georgetown University Medical Center, Washington, District of Columbia
MedStar Georgetown University Hospital, Washington, District of Columbia
Moffitt Cancer Center - International Plaza, Tampa, Florida
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Moffitt Cancer Center - McKinley Campus, Tampa, Florida
Moffitt McKinley Hospital, Tampa, Florida
Moffitt Cancer Center at Wesley Chapel, Wesley Chapel, Florida
Georgia Cancer Specialists - Athens, Athens, Georgia
Georgia Cancer Specialists - Annex, Atlanta, Georgia
Atlanta Cancer Care - Atlanta, Atlanta, Georgia
Georgia Cancer Specialists-Northside, Atlanta, Georgia
Northside Hospital, Inc.- Central Research Department, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Georgia Cancer Specialists - Blairsville, Blairsville, Georgia
Georgia Cancer Specialists - Canton, Canton, Georgia
Atlanta Cancer Care - Cumming, Cumming, Georgia
Georgia Cancer Specialists - Cumming, Cumming, Georgia
Georgia Cancer Specialists - Decatur, Decatur, Georgia
Suburban Hematology-Oncology Associates - Duluth, Duluth, Georgia
Suburban Hematology-Oncology Associates- Lawrenceville, Lawrenceville, Georgia
Georgia Cancer Specialists - Macon, Macon, Georgia
Georgia Cancer Specialists - Marietta, Marietta, Georgia
Memorial Hospital, Shiloh, Illinois
Siteman Cancer Center - Shiloh, Shiloh, Illinois
Massachusetts General Hospital., Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
Dana Farber Cancer Institute, Boston, Massachusetts
Dana Farber Cancer Institute- Chestnut Hill, Newton, Massachusetts
Siteman Cancer Center - West County, Creve Coeur, Missouri
Siteman Cancer Center - North County, Florissant, Missouri
Saint Luke's Cancer Institute LLC, Kansas City, Missouri
Saint Luke's Hospital Investigational Pharmacy, Kansas City, Missouri
St Lukes Hospital, Kansas City, Missouri
Barnes-Jewish Hospital, Saint Louis, Missouri
Washington University in St Louis., Saint Louis, Missouri
Washington University School of Medicine - Siteman Cancer Center, Saint Louis, Missouri
Siteman Cancer Center - South County, Saint Louis, Missouri
Siteman Cancer Center - St Peters, Saint Peters, Missouri
Renown Regional Medical Center, Reno, Nevada
San Juan Oncology Associates, Farmington, New Mexico
Memorial Sloan Kettering Cancer Center - Main Hospital, New York, New York
Zangmeister Cancer Center, Columbus, Ohio
Saint Francis Hospital / Bon Secours - South Carolina, Greenville, South Carolina
Sarah Cannon Research Institute - Pharmacy, Nashville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Tennessee Oncology-Nashville/Sarah Cannon Research Institute, Nashville, Tennessee
Parkland Health and Hospital System, Dallas, Texas
University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas, Texas
University of Texas Southwestern Medical Center-Simmons Cancer Center Pharmacy, Dallas, Texas
University of Texas Southwestern Medical Center Simmons Cancer Center - Redbird, Dallas, Texas
University of Texas Southwestern Medical Center Clinical Lab-Zale Lipshy University Hospital, Dallas, Texas
University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
University of Texas Southwestern Simmons Cancer Center - Fort Worth, Fort Worth, Texas
University of Texas Southwestern Medical Center Simmons Cancer Center - Richardson/Plano, Richardson, Texas
Harborview Medical Center, Seattle, Washington
Fred Hutchinson Cancer Center / Seattle Cancer Care Alliance / University of Washington, Seattle, Washington
University of Washington Medical Center, Seattle, Washington
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
Carbone Cancer Center / University of Wisconsin, Madison, Wisconsin
Peninsula & South Eastern Hematology and Oncology Group (PASO), Frankston, Victoria
Slade Pharmacy Frankston, Frankston, Victoria
Slade Health, Mount Waverley, Victoria
Peninsula & South Eastern Hematology and Oncology Group (PASO), Frankston, Not set
BC Cancer Kelowna., Kelowna, British Columbia
Ottawa Hospital Cancer Centre, Ottawa, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
University Health Network, Princess Margaret Hospital, Toronto, Ontario
Universitatsklinikum Essen, Essen, Not set
Universitatsklinikum Heidelberg, Heidelberg, Not set
Klinikums rechts der Isar der TU München, Muenchen, Not set
A.O.U. Federico II, Napoli, Campania
Azienda Ospedaliera Universitaria (AOU) Federico II, Napoli, Campania
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale., Napoli, Campania
Istituto Europeo di Oncologia, Milano, Lombardia
Niguarda Ca' Granda Hospital, Milano, Lombardia
Humanitas Istituto Clinico Catanese, Misterbianco (CT), Sicilia
Azienda Ospedaliera Universitaria Integrata di Verona., Verona, Veneto
A.O.U. Federico II- U.O.C. Diagnostica per lmmagini e Radioterapia, Napoli, Not set
Dong-A University Hospital, Busan, Other
National Cancer Center, Goyang-si, Other
Chungbuk National University Hospital, Cheongju-si, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
St. Vincent's Hospital, The Catholic University of Korea, Suwon-si, Not set
Quirén Salud Barcelona, Barcelona, Not set
Hospital Universitari Vall d´Hebron, Barcelona, Not set
CETIR Grup Medic, Barcelona, Not set
Hospital Universitario de Basurto, Bilbao, Not set
Grupo Hospitalario QuironSalud, Erandio Bizkaia, Not set
L'Institut Catala d'Oncologia., L'Hospitalet de Llobregat, Not set
Farmacia-Ensayos. Planta S - Hospital Universitario HM Sanchinarro-CIOCC-START Madrid, Madrid, Not set
START Madrid-CIOCC_Hospital HM Sanchinarro, Madrid, Not set
Ecg Medica Sl, Valencia, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
National Taiwan University Hospital, Taipei, Not set
National Taiwan University Cancer Center, Taipei, Not set
The Royal Marsden Hospital, Sutton, Surrey
St Bartholomew's Hospital, London, Not set
The Royal Marsden Hospital, London, Not set
The Royal Marsden NHS Foundation Trust (RM), London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Royal Marsden NHS Foundation Trust, Sutton, Not set
Conditions: Breast Neoplasms, Gastroesophageal Junction Adenocarcinoma, HER2 Low Breast Neoplasms, HER2 Positive Breast Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms, Metastatic Breast Cancer, Metastatic Gastric Cancer, Advanced Breast Cancer, Advanced Gastric Cancer
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Recruiting
This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810), called "study drugs". The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the combination of fianlimab and cemiplimab is in treating melanoma, in comparison with the combination of two medications, relatlimab and nivolumab, commercialized under the bra... Read More
This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810), called "study drugs". The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the combination of fianlimab and cemiplimab is in treating melanoma, in comparison with the combination of two medications, relatlimab and nivolumab, commercialized under the brand name Opdualag™ and approved for the treatment of melanoma in adults and children.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drugs.
* How much study drug is in the blood at different times.
* Whether the body makes antibodies against the study drugs (which could make the drug less effective or could lead to side effects) Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Ironwood Cancer & Research Centers, Chandler, Arizona +98 locations
Ironwood Cancer & Research Centers, Chandler, Arizona
Banner MD Anderson Cancer Center, Gilbert, Arizona
Arizona Oncology Associates, Tucson, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Providence Medical Foundation, Fullerton, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
University of California Los Angeles, Los Angeles, California
St. Joseph Hospital Orange, Orange, California
Eisenhower Medical Center, Rancho Mirage, California
Sutter Health, Sacramento, California
University of California San Francisco (UCSF), San Francisco, California
Sansum Clinic, Santa Barbara, California
St John's Cancer Institute, Santa Monica, California
Rocky Mountain Regional VA Medical Center, Aurora, Colorado
University of Colorado Cancer Center, Aurora, Colorado
The Melanoma And Skin Cancer Institute, Englewood, Colorado
UCHealth, Fort Collins, Colorado
Yale Cancer Center, New Haven, Connecticut
Clermont Oncology Center, Clermont, Florida
Mayo Clinic Florida, Jacksonville, Florida
Cancer Specialist of North Florida, Jacksonville, Florida
Boca Raton Clinical Research (BRCR) Global, Tamarac, Florida
H. Lee Moffitt Cancer Center, Tampa, Florida
University Cancer & Blood Center, Athens, Georgia
John B. Amos Cancer Center, Columbus, Georgia
Beacon Clinic, Coeur d'Alene, Idaho
Hope and Healing Cancer Services, Hinsdale, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare, Peoria, Illinois
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana
The University of Kansas Cancer Center, Westwood, Kansas
Markey Cancer Center Clinical Research Organization, Lexington, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Maryland Oncology Hematology, P.A., Columbia, Maryland
Karmanos Cancer Institute, Detroit, Michigan
Minnesota Oncology Hematology, P.A, Fridley, Minnesota
Allina Health Cancer Institute, Minneapolis, Minnesota
VA St. Louis Healthcare System, Saint Louis, Missouri
Washington University, Saint Louis, Missouri
Mercy South, Saint Louis, Missouri
St. Vincent Healthcare, Billings, Montana
Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha, Nebraska
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
John Theurer Cancer Center, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
The Valley Hospital Inc., Paramus, New Jersey
New York Oncology Hematology, Albany, New York
Messino Cancer Center, Asheville, North Carolina
Levine Cancer Institute, Charlotte, North Carolina
Novant Health Cancer Institute, Charlotte, North Carolina
Novant Health Weisiger Cancer Institute - Charlotte, Charlotte, North Carolina
Duke Health System, Durham, North Carolina
Novant Health Zimmer Cancer Institute - Wilmington, Wilmington, North Carolina
Oncology Hematology Care Clinical Trials, Cincinnati, Ohio
Seidman Cancer Center, Cleveland, Ohio
Oklahoma Cancer Specialists and Research Institute, LLC, Tulsa, Oklahoma
Oncology Associates of Oregon PC, Eugene, Oregon
Kaiser Foundation Hospitals, Portland, Oregon
St. Luke's University Health Network, Easton, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania
Lifespan Cancer Institute, Providence, Rhode Island
Saint Francis Cancer Center, Greenville, South Carolina
Tennessee Oncology - Chattanooga, Chattanooga, Tennessee
University of Tennessee Medical Center, Knoxville, Tennessee
Sarah Cannon Research Institute (SCRI) Oncology Partners, Nashville, Tennessee
Tennessee Oncology, Nashville, Tennessee
Texas Oncology - Austin Midtown, Midtown Medical Center I, Austin, Texas
Texas Oncology - Austin Central, Central Austin Cancer Center, Austin, Texas
Texas Oncology - Bedford, Bedford, Texas
Texas Oncology - Medical City, Dallas, Texas
Texas Oncology, Dallas, Texas
Center For Disease And Blood Disorder, Fort Worth, Texas
Texas Oncology - Fort Worth, Fort Worth, Texas
Texas Oncology - Grapevine, Grapevine, Texas
Texas Oncology - Harlingen, Medical Arts Pavillion, Harlingen, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
Texas Oncology - Longview, Longview, Texas
Joe Arrington Cancer Research & Treatment Center, Lubbock, Texas
Texas Oncology - McAllen, McAllen, Texas
Texas Oncology-Palestine Cancer Center, Palestine, Texas
The University of Texas Health Science Center at Tyler D/B/A UT Health East Texas HOPE Cancer Center, Tyler, Texas
Texas Oncology-Tyler, Northeast Texas Cancer Institute, Tyler, Texas
Texas Oncology - Weslaco, Knapp Medical Plaza, Weslaco, Texas
University of Utah Huntsman Cancer Institute, Salt Lake City, Utah
University of Virginia, Charlottesville, Virginia
Virginia Cancer Specialists, PC, Fairfax, Virginia
Virginia Oncology Associates, Norfolk, Virginia
Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia
Oncology & Hematology Associates of Southwest Virginia, Inc., Roanoke, Virginia
Swedish Cancer Institute - Edmonds Campus, Edmonds, Washington
Swedish Cancer Institute - Issaquah Campus, Issaquah, Washington
Swedish Cancer Institute, Seattle, Washington
West Virginia University, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
London Regional Cancer Centre, London, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Centre Hospitalier Universitaire de Quebec (CHUQ) - Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Conditions: Melanoma
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