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All Clinical Trials in Canada
A listing of 3894 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.
Recruiting
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess how safe and effective Upadacitinib is in treating pediatric participants with UC. Adverse events and change in disease activity will be assessed.
Upadacitinib (RINVOQ) is a drug approved in adults for moderate- to severely active UC and is being developed for moderate- to severely active UC in pediatric participa... Read More
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess how safe and effective Upadacitinib is in treating pediatric participants with UC. Adverse events and change in disease activity will be assessed.
Upadacitinib (RINVOQ) is a drug approved in adults for moderate- to severely active UC and is being developed for moderate- to severely active UC in pediatric participants. This study is conducted in 2 periods: Period 1 is comprised of two phases: an 8-week open-label induction phase which means that the study doctor and patients know that participants will receive UPA Dose-A (or the adult equivalent based on body weight) followed by a 44-week double-blind maintenance phase meaning that neither the participants nor the study doctors will know which dose of upadacitinib will be given(UPA Dose B or Dose C). Period 2 is a 260 week open-label extension (OLE) of Period 1. Approximately 110 pediatric participants with moderate to severely active UC will be enrolled at up to 100 sites worldwide.
Participants will receive upadacitinib oral tablets once daily or oral solution twice daily at approximately the same time each day, with or without food. Participants will be followed up for 30 days after each phase (i.e. after induction, maintenance, OLE) and only if a participant doesn't continue into the next phase.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires. Read Less
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
07/16/2025
Locations: Phoenix Children's Hospital /ID# 250135, Phoenix, Arizona +85 locations
Phoenix Children's Hospital /ID# 250135, Phoenix, Arizona
Arkansas Children's Hospital /ID# 250106, Little Rock, Arkansas
Kindred Medical Institute - Corona /ID# 255484, Corona, California
UCSF Benioff Children's Hospital - Oakland /ID# 255067, Oakland, California
Lucile Packard Children's Hospital /ID# 258430, Palo Alto, California
Children's Hospital Colorado - Aurora /ID# 250110, Aurora, Colorado
Nemours/Alfred duPont Hospital for Children /ID# 255483, Wilmington, Delaware
Childrens Healthcare of Atlanta - Center for Advanced Pediatrics /ID# 255069, Atlanta, Georgia
OSF St. Francis Medical Center /ID# 256968, Peoria, Illinois
Massachusetts General Hospital /ID# 250142, Boston, Massachusetts
Boston Children's Hospital /ID# 250108, Boston, Massachusetts
NYU Langone Hospital - Long Island /ID# 250136, Mineola, New York
The Mount Sinai Hospital /ID# 250141, New York, New York
Univ NC Chapel Hill /ID# 254541, Chapel Hill, North Carolina
Levine Children's Hospital /ID# 250131, Charlotte, North Carolina
UH Cleveland Medical Center /ID# 250134, Cleveland, Ohio
Children's Hospital of Philadelphia - Main /ID# 258773, Philadelphia, Pennsylvania
Children's Specialty Group /ID# 256966, Norfolk, Virginia
University of Wisconsin - Madison /ID# 250632, Madison, Wisconsin
Children's Hospital at Westmead /ID# 255556, Westmead, New South Wales
Queensland Children's Hospital /ID# 261032, South Brisbane, Queensland
Monash Health - Monash Medical Centre /ID# 254726, Clayton, Victoria
Perth Children'S Hospital /ID# 254727, Perth, Western Australia
Universitair Ziekenhuis Antwerpen /ID# 251184, Edegem, Antwerpen
Universitair Ziekenhuis Leuven /ID# 251185, Leuven, Vlaams-Brabant
Hospital Pequeno Príncipe /ID# 251911, Curitiba, Parana
Hospital e Maternidade Celso Pierro - PUC-Campinas /ID# 251912, Campinas, Sao Paulo
Rocco & Nazato Servicos Medicos /ID# 251910, São Paulo, Sao Paulo
UMHAT Sveti Georgi /ID# 251949, Plovdiv, Not set
Specialized Hospital For Active Treatment Of Children Diseases Prof. Ivan Mitev /ID# 251285, Sofiya, Not set
UMHAT Sveta Marina /ID# 251948, Varna, Not set
Alberta Health Services /ID# 252088, Edmonton, Alberta
IWK Health Center /ID# 250943, Halifax, Nova Scotia
Hospital for Sick Children /ID# 250945, Toronto, Ontario
Fakultní Nemocnice Plzeň-Lochotín /ID# 253284, Pilsen, Plzen-jih
Fakultní nemocnice v Motole /ID# 251955, Prague, Praha 5
CHU Bordeaux - Hopital Pellegrin /ID# 253182, Bordeaux, Nouvelle-Aquitaine
Hospices Civils de Lyon - Hôpital Femme Mère Enfant /ID# 251502, Bron CEDEX, Rhone
AP-HP - Hopital Necker /ID# 251658, Paris, Not set
Hopitaux de Paris (AP-HP) - Hopital Robert Debre - CHU /ID# 252069, Paris, Not set
CHU Toulouse - Hopital Paule de Viguier /ID# 252070, Toulouse, Not set
Dr. von Haunerschen Kinderspital /ID# 251440, Muenchen, Bayern
Universitaetsklinikum Muenster /ID# 256763, Muenster, Nordrhein-Westfalen
Klinikum St. Georg gGmbH /ID# 262481, Leipzig, Sachsen
Charite Universitaetsmedizin Berlin Campus Virchow-Klinikum /ID# 251434, Berlin, Not set
Agia Sofia Hospital /ID# 250697, Athens, Attiki
University General Hospital of Heraklion PA.G.N.I /ID# 250696, Heraklion, Kriti
Debreceni Egyetem-Klinikai Kozpont /ID# 251835, Debrecen, Hajdu-Bihar
Semmelweis Egyetem /ID# 251083, Budapest, Not set
Schneider Children's Medical Center /ID# 254833, Petah Tikva, HaMerkaz
Shaare Zedek Medical Center /ID# 254832, Jerusalem, Yerushalayim
Azienda Ospedaliero Universitaria Meyer /ID# 251624, Florence, Firenze
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 251625, Rome, Roma
Ospedale Maggiore Carlo Alberto Pizzardi /ID# 251626, Bologna, Not set
Tsujinaka Hospital Kashiwanoha /ID# 251930, Kashiwa-shi, Chiba
Kurume University Hospital /ID# 251927, Kurume-shi, Fukuoka
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 251928, Sapporo-shi, Hokkaido
Miyagi Children's Hospital /ID# 251931, Sendai-shi, Miyagi
Osaka Women's and Children's Hospital /ID# 252397, Izumi-Shi, Osaka
Osaka General Medical Center /ID# 253678, Osaka-shi, Osaka
Saitama Children's Medical Center /ID# 252362, Saitama-shi, Saitama
Institute of Science Tokyo Hospital /ID# 251929, Bunkyo-ku, Tokyo
Tokyo Metropolitan Children's Medical Center /ID# 252477, Fuchu-shi, Tokyo
National Center for Child Health and Development /ID# 251926, Setagaya-ku, Tokyo
Seoul National University Hospital /ID# 252024, Seoul, Seoul Teugbyeolsi
Samsung Medical Center /ID# 252023, Seoul, Seoul Teugbyeolsi
Kyungpook National University Chilgok Hospital /ID# 252663, Daegu, Not set
Servicios de Oncologia Medica Integral SA de CV /ID# 252974, San Pedro Garza Garcia, Nuevo Leon
Amsterdam UMC, locatie AMC /ID# 250845, Amsterdam, Noord-Holland
Universitair Medisch Centrum Groningen /ID# 252003, Groningen, Not set
Christchurch Hospital /ID# 254703, Christchurch, Canterbury
Starship Child Health /ID# 254702, Auckland, Not set
Gastromed Sp. z o.o /ID# 251290, Torun, Kujawsko-pomorskie
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 251289, Warsaw, Mazowieckie
Clinical Research Puerto Rico /ID# 266477, San Juan, Not set
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 252105, Ferrol, A Coruna
Hospital Sant Joan de Deu /ID# 251194, Esplugues de Llobregat, Barcelona
Hospital Universitario Vall d'Hebron /ID# 252104, Barcelona, Not set
Hospital Regional Universitario de Malaga /ID# 251193, Malaga, Not set
National Taiwan University Hospital /ID# 251650, Taipei City, Taipei
Linkou Chang Gung Memorial Hospital /ID# 251654, Taoyuan City, Not set
Sheffield Children's Hospital NHS Foundation Trust /ID# 251600, Sheffield, England
Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 251917, London, Greater London
Great Ormond Street Children's Hospital /ID# 252126, London, Greater London
University Hospital Southampton NHS Foundation Trust /ID# 252097, Southampton, Hampshire
Birmingham Women's and Children's NHS Foundation Trust /ID# 253072, Birmingham, Not set
Conditions: Ulcerative Colitis
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
Recruiting
This is a Phase 1, multicenter, open-label dose escalation study to determine the safety and tolerability of intratumoral (IT) injection of tolododekin alfa (ANK-101) in participants with advanced solid tumors who have progressed during or after receiving standard of care (SOC) therapy or who will not benefit from such therapy. The study will be conducted in three parts; in Part 1, participants with superficial lesions will receive ANK-101 as a single agent; in Part 2, participants with visceral... Read More
This is a Phase 1, multicenter, open-label dose escalation study to determine the safety and tolerability of intratumoral (IT) injection of tolododekin alfa (ANK-101) in participants with advanced solid tumors who have progressed during or after receiving standard of care (SOC) therapy or who will not benefit from such therapy. The study will be conducted in three parts; in Part 1, participants with superficial lesions will receive ANK-101 as a single agent; in Part 2, participants with visceral lesions will receive ANK-101 as a single agent; and in Part 3, participants with cutaneous squamous cell carcinoma (CSCC) will receive ANK-101 in combination with cemiplimab. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: National Cancer Institute, Bethesda, Maryland +4 locations
National Cancer Institute, Bethesda, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Providence Cancer Institute, Portland, Oregon
Hillman Cancer Center, Pittsburgh, Pennsylvania
Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Advanced Solid Tumor, Cutaneous Tumor, Subcutaneous Tumor, Malignant Solid Tumor, Solid Tumor, Metastatic Solid Tumor, Metastasis to Soft Tissue, Non Small Cell Lung Cancer, Cutaneous Squamous Cell Carcinoma
Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
Recruiting
A global study to assess the efficacy and tolerability of rilvegostomig compared to placebo in combination with investigator's choice of chemotherapy in participants with BTC after surgical resection with curative intent.
A global study to assess the efficacy and tolerability of rilvegostomig compared to placebo in combination with investigator's choice of chemotherapy in participants with BTC after surgical resection with curative intent. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Research Site, Birmingham, Alabama +209 locations
Research Site, Birmingham, Alabama
Research Site, Phoenix, Arizona
Research Site, Duarte, California
Research Site, Los Angeles, California
Research Site, Newport Beach, California
Research Site, Orange, California
Research Site, Stanford, California
Research Site, West Hollywood, California
Research Site, Aurora, Colorado
Research Site, Denver, Colorado
Research Site, Littleton, Colorado
Research Site, Washington, District of Columbia
Research Site, Washington, District of Columbia
Research Site, Altamonte Springs, Florida
Research Site, Gainesville, Florida
Research Site, Jacksonville, Florida
Research Site, Atlanta, Georgia
Research Site, Chicago, Illinois
Research Site, Iowa City, Iowa
Research Site, Kansas City, Kansas
Research Site, Lexington, Kentucky
Research Site, New Orleans, Louisiana
Research Site, Baltimore, Maryland
Research Site, Grand Rapids, Michigan
Research Site, Rochester, Minnesota
Research Site, Saint Louis, Missouri
Research Site, Commack, New York
Research Site, Mineola, New York
Research Site, Philadelphia, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Nashville, Tennessee
Research Site, Dallas, Texas
Research Site, Tyler, Texas
Research Site, Vancouver, Washington
Research Site, Camperdown, Not set
Research Site, Clayton, Not set
Research Site, Murdoch, Not set
Research Site, Reservoir, Not set
Research Site, Westmead, Not set
Research Site, Brussels, Not set
Research Site, Bruxelles, Not set
Research Site, Edegem, Not set
Research Site, Leuven, Not set
Research Site, Natal, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Santa Maria, Not set
Research Site, Santo Andre, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, Vitória, Not set
Research Site, Vancouver, British Columbia
Research Site, Moncton, New Brunswick
Research Site, Halifax, Nova Scotia
Research Site, Brampton, Ontario
Research Site, Kingston, Ontario
Research Site, London, Ontario
Research Site, Mississauga, Ontario
Research Site, Ottawa, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Quebec, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Deyang, Not set
Research Site, Fuzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guiyang, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Hefei, Not set
Research Site, Hefei, Not set
Research Site, Kunming, Not set
Research Site, Lanzhou, Not set
Research Site, Lishui, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nanjing, Not set
Research Site, Nanning, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Tianjin Shi, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Zhengzhou, Not set
Research Site, Herlev, Not set
Research Site, Marseille, Not set
Research Site, Montpellier, Not set
Research Site, Paris Cedex 5, Not set
Research Site, Pessac, Not set
Research Site, Rennes, Not set
Research Site, Strasbourg, Not set
Research Site, Toulouse Cedex 9, Not set
Research Site, Villejuif, Not set
Research Site, Berlin, Not set
Research Site, Bonn, Not set
Research Site, Dortmund, Not set
Research Site, Dresden, Not set
Research Site, Erlangen, Not set
Research Site, Essen, Not set
Research Site, Esslingen A. N., Not set
Research Site, Frankfurt, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Köln, Not set
Research Site, Leipzig, Not set
Research Site, Lübeck, Not set
Research Site, München, Not set
Research Site, München, Not set
Research Site, Münster, Not set
Research Site, Stuttgart, Not set
Research Site, Tuebingen, Not set
Research Site, Ulm, Not set
Research Site, Hong Kong, Not set
Research Site, Hong Kong, Not set
Research Site, Hong Kong, Not set
Research Site, Shatin, Not set
Research Site, Delhi, Not set
Research Site, Kolkata, Not set
Research Site, Mumbai, Not set
Research Site, Mysuru, Not set
Research Site, New Delhi, Not set
Research Site, New Delhi, Not set
Research Site, Vadodara, Not set
Research Site, Varanasi, Not set
Research Site, Firenze, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Padova, Not set
Research Site, Pisa, Not set
Research Site, Rozzano, Not set
Research Site, Tricase, Lecce, Not set
Research Site, Chuo-ku, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Kitaadachi-gun, Not set
Research Site, Koto-ku, Not set
Research Site, Mitaka-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Suita-shi, Not set
Research Site, Toyama-shi, Not set
Research Site, Ube, Not set
Research Site, Wakayama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Oslo, Not set
Research Site, Bydgoszcz, Not set
Research Site, Katowice, Not set
Research Site, Koszalin, Not set
Research Site, Kraków, Not set
Research Site, Lublin, Not set
Research Site, Przemysl, Not set
Research Site, Tomaszów Mazowiecki, Not set
Research Site, Warszawa, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, L'Hospitalet de Llobregat, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Pamplona, Not set
Research Site, Santander, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Tainan City, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan, Not set
Research Site, Hat Yai, Not set
Research Site, Khon Kaen, Not set
Research Site, Muang, Not set
Research Site, Muang, Not set
Research Site, Naimuang, Not set
Research Site, Sisaket, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Antalya, Not set
Research Site, Erzurum, Not set
Research Site, Fatih-Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Samsun, Not set
Research Site, Cambridge, Not set
Research Site, Edgbaston, Not set
Research Site, Glasgow, Scotland, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Sutton, Not set
Conditions: Biliary Tract Cancer
Fabry Disease Registry & Pregnancy Sub-registry
Recruiting
The Fabry Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Fabry disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician.
The primary objectives of the Registry are:
* To enhance the understanding of the variability, progression, and natural history of F... Read More
The Fabry Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Fabry disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician.
The primary objectives of the Registry are:
* To enhance the understanding of the variability, progression, and natural history of Fabry disease, including heterozygous females with the disease;
* To assist the Fabry medical community with the development of recommendations for monitoring patients and reports on patient outcomes to help optimize patient care;
* To characterize and describe the Fabry population as a whole;
* To evaluate the long-term safety and effectiveness of Fabrazyme®
Fabry Pregnancy Sub-registry: This Sub-registry is a multicenter, international, longitudinal, observational, and voluntary program designed to track pregnancy outcomes for any pregnant woman enrolled in the Fabry Registry, regardless of whether she is receiving disease-specific therapy (such as enzyme replacement therapy with agalsidase beta) and irrespective of the commercial product with which she may be treated. Data from the Sub-registry are also used to fulfill various global regulatory requirements, to support product development/reimbursement, and for other research and non-research-related purposes. No experimental intervention is given; thus a patient will undergo clinical assessments and receive standard of care treatment as determined by the patient's physician. If a patient consents to this Sub-registry, information about the patient's medical and obstetric history, pregnancy, and birth will be collected, and, if a patient consents to data collection for her infant, data on infant growth through month 36 postpartum will be collected. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
07/16/2025
Locations: University of Alabama Birmingham- Nephrology- Site Number : 840018, Birmingham, Alabama +281 locations
University of Alabama Birmingham- Nephrology- Site Number : 840018, Birmingham, Alabama
University of Alabama Birmingham- Nephrology- Site Number : 840073, Birmingham, Alabama
Phoenix Children's Hospital- Site Number : 840003, Phoenix, Arizona
University of Arizona- Site Number : 840015, Tucson, Arizona
Arkansas Childrens Hospital- Site Number : 840109, Little Rock, Arkansas
University of Arkansas for Medical Sciences- Site Number : 840113, Little Rock, Arkansas
University of California at Irvine- Site Number : 840036, Irvine, California
Southern California Permanente Medical Group- Site Number : 840108, Los Angeles, California
USC Health Sciences Center Dept of Genetics- Site Number : 840082, Los Angeles, California
UCLA School Of Medicine- Site Number : 840088, Los Angeles, California
Children's Hospital Oakland- Site Number : 840029, Oakland, California
Children's Hospital of Orange County- Site Number : 840074, Orange, California
Stanford Unviersity MC Dept of Genetics- Site Number : 840022, Palo Alto, California
UC Davis MIND Institute- Site Number : 840010, Sacramento, California
Kaiser Permanente Hospital- Site Number : 840042, Sacramento, California
Loma Linda University Children's Hospital- Site Number : 840117, San Bernardino, California
University of California at San Diego- Site Number : 840007, San Diego, California
University of California at San Francisco- Site Number : 840051, San Francisco, California
Yale - Site Number : 840047, New Haven, Connecticut
Children's National Medical Center- Site Number : 840067, Washington, District of Columbia
University Hematology Oncology- Site Number : 840075, Coral Springs, Florida
University of Florida Dept of Genetics- Site Number : 840083, Gainesville, Florida
University of Florida Pediatrics Genetics- Site Number : 840121, Jacksonville, Florida
The Atwal Clinic- Site Number : 840112, Jacksonville, Florida
University Of Miami SOM- Site Number : 840006, Miami, Florida
University of Florida-Genetics- Site Number : 840096, Tampa, Florida
Emory University School of Medicine- Human Genetics- Site Number : 840060, Decatur, Georgia
University of Colorado at Denver Genetics- Site Number : 840068, Aurora, Illinois
Ann and Robert Lurie Children's Hospital- Site Number : 840013, Chicago, Illinois
Rush University Medical Center Genetics- Site Number : 840079, Chicago, Illinois
Indianapolis University School of Medicine- Site Number : 840027, Indianapolis, Indiana
University of Iowa- Site Number : 840032, Iowa City, Iowa
University of Kansas Medical Center- Site Number : 840071, Kansas City, Kansas
University of Louisville- Genetics- Site Number : 840030, Louisville, Kentucky
Ochsner Medical Center- Site Number : 840120, Baton Rouge, Louisiana
Tulane University Medical Center- Site Number : 840001, New Orleans, Louisiana
Maine Medical Center Pediatrics- Site Number : 840064, Portland, Maine
John Hopkins- Site Number : 840044, Baltimore, Maryland
Massachusetts General Hospital-Genetics- Site Number : 840062, Boston, Massachusetts
Brigham and Women's Hospital-Neurology- Site Number : 840103, Boston, Massachusetts
Boston Children's Hospital- Site Number : 840092, Boston, Massachusetts
Baystate Health- Site Number : 840002, Springfield, Massachusetts
University of Michigan Pediatrics- Site Number : 840107, Ann Arbor, Michigan
Children's Hospital of Michigan- Site Number : 840066, Detroit, Michigan
Spectrum for Health- Site Number : 840019, Grand Rapids, Michigan
Infusion Associates- Site Number : 840050, Grand Rapids, Michigan
Children's Health Care- Site Number : 840114, Minneapolis, Minnesota
Children's Hospital and Clinics of Minnesota- Site Number : 840046, Minneapolis, Minnesota
University of Minnesota Medical Center Pediatrics- Site Number : 840076, Minneapolis, Minnesota
University of Missouri Health System Department of Genetics- Site Number : 840031, Columibia, Missouri
Washington University of St. Louis- Site Number : 840100, Saint Louis, Missouri
Billings Clinic - Billings- Site Number : 840118, Billings, Montana
Shodair Children's Hospital- Site Number : 840090, Helena, Montana
University of Nebraska Medical Center- Pediatrics- Site Number : 840084, Omaha, Nebraska
Children's Specialty Center of Nevada- Site Number : 840008, Las Vegas, Nevada
Cooper Health Center- Site Number : 840098, Camden, New Jersey
Joseph M. Sanzari Children's Hospital- Site Number : 840101, Hackensack, New Jersey
Atlantic Health System- Site Number : 840099, Morristown, New Jersey
St. Peter's University Hospital- Site Number : 840016, New Brunswick, New Jersey
St. Joseph's Children's Hospital- Site Number : 840057, Paterson, New Jersey
Northwell Health- Site Number : 840102, Manhasset, New York
New York University School Of Medicine- Site Number : 840040, New York, New York
Metropolitan Hospital Center- Site Number : 840110, New York, New York
Icahn School of Medicine at Mount Sinai- Site Number : 840080, New York, New York
University of Rochester Medical Center SOM- Site Number : 840105, Rochester, New York
State University of New York- Site Number : 840052, Syracuse, New York
New York Medical College- Site Number : 840039, Valhalla, New York
Carolinas Medical Center- Site Number : 840065, Charlotte, North Carolina
Duke University Medical Center Genetics Dept- Site Number : 840045, Durham, North Carolina
Cincinnati Children's Hospital-Genetics- Site Number : 840033, Cincinnati, Ohio
University Hospitals Cleveland Medical Center- Site Number : 840119, Cleveland, Ohio
Cleveland Clinic Foundation Pediatrics- Site Number : 840048, Cleveland, Ohio
Nationwide Children's Hospital- Site Number : 840091, Columbus, Ohio
Ohio State University Department of Genetics- Site Number : 840097, Columbus, Ohio
LSD Data Registry Site LLC- Site Number : 840094, Dublin, Ohio
Oregon Health and Science University- Site Number : 840116, Portland, Oregon
Oregon Health and Scinece University- Site Number : 840038, Portland, Oregon
Geisinger- Site Number : 840111, Danville, Pennsylvania
Penn State University Medical Center-Neurology- Site Number : 840104, Hershey, Pennsylvania
Children's Hospital of Philadelphia HUP Medical Genetics- Site Number : 840089, Philadelphia, Pennsylvania
Children's Hospital of Philadelphia- Site Number : 840034, Philadelphia, Pennsylvania
University of Pittsburgh- Site Number : 840023, Pittsburgh, Pennsylvania
Rhode Island Hospital Genetics- Site Number : 840053, Providence, Rhode Island
Greenwood Genetcs- Site Number : 840055, Greenville, South Carolina
Vanderbilt University Hospital-Pediatrics- Site Number : 840049, Nashville, Tennessee
Baylor Research Center- Site Number : 840058, Dallas, Texas
Cook Children's Health Care System- Site Number : 840024, Fort Worth, Texas
University of Utah Department of Medical Genetics- Site Number : 840043, Salt Lake City, Utah
University of Virginia School of Medicine-Pediatrics- Site Number : 840078, Charlottesville, Virginia
O&O Alpan, LLC- Site Number : 840025, Fairfax, Virginia
Children's Hospital of the Kings Daughters- Site Number : 840072, Norfolk, Virginia
Seattle Children's Hospital- Site Number : 840028, Seattle, Washington
University Of Washington Medical Center- Site Number : 840059, Seattle, Washington
Multicare Health System ¿ Mary Bridge Childrens Hospital- Site Number : 840115, Tacoma, Washington
Children's Hospital of Wisconsin-Pediatrics- Site Number : 840054, Milwaukee, Wisconsin
Investigational Site Number : 153032, Ciudad Autónoma de Buenos Aires, Buenos Aires
Investigational Site Number : 153172, Buenos Aires, Not set
Investigational Site Number : 153130, Buenos Aires, Not set
Investigational Site Number : 153194, Catamarca, Not set
Investigational Site Number : 032005, La Rioja, Not set
Investigational Site Number : 032004, Santa Fe, Not set
Investigational Site Number : 036013, Westmead, New South Wales
Investigational Site Number : 151069, Westmead, New South Wales
Investigational Site Number : 153063, Brisbane, Queensland
Investigational Site Number : 151002, Adelaide, South Australia
Investigational Site Number : 153040, Parkville, Victoria
Investigational Site Number : 153090, Perth, Western Australia
Investigational Site Number : 150722, Antwerp, Not set
Investigational Site Number : 153133, Antwerp, Not set
Investigational Site Number : 153001, Brussels, Not set
Investigational Site Number : 0560008, Brussels, Not set
Investigational Site Number : 150517, Brussels, Not set
Investigational Site Number : 151668, Leuven, Not set
Investigational Site Number : 154275, Liège, Not set
Investigational Site Number : 153100, Seraing, Not set
Clínica Senhor do Bonfim LTDA- Site Number : 076008, Feira de Santana, Bahia
Medicordis- Site Number : 076009, Brasília, Distrito Federal
Hospital Geral e Maternidade de Cuiabá- Site Number : 076006, Cuiabá, Mato Grosso
CTDR - Centro de Tratamento de Doenças Renais EIRELI- Site Number : 076007, Uberlândia, Minas Gerais
Instituto do Rim do Paraná- Site Number : 076004, Curitiba, Paraná
Instituto de Medicina Integral Professor Fernando Figueira - IMIP - Site Number : 076005, Recife, Pernambuco
Saúde Center Clínica - Clínica Médica Nossa Senhora de Fátima - Site Number : 076002, Tapejara, Rio Grande Do Sul
Hospital Universitário Professor Polydoro Ernani de São Thiago - UFSC- Site Number : 076012, Florianopolis, Santa Catarina
Hospital e Maternidade Celso Pierro - PUC-Campinas- Site Number : 076013, Campinas, São Paulo
Serviço de Terapia Renal de Ourinhos- Site Number : 076011, Ourinhos, São Paulo
Instituto de Genética e Erros Inatos do Metabolismo- Site Number : 076001, São Paulo, Not set
Investigational Site Number : 153169, Sofia, Not set
Investigational Site Number : 100001, Sofia, Not set
Investigational Site Number : 124014, Calgary, Alberta
Investigational Site Number : 124002, Edmonton, Alberta
Investigational Site Number : 124010, Vancouver, British Columbia
Investigational Site Number : 124011, Vancouver, British Columbia
Investigational Site Number : 124019, Winnipeg, Manitoba
Investigational Site Number : 124022, Moncton, New Brunswick
Investigational Site Number : 124023, St. John's, Newfoundland and Labrador
Investigational Site Number : 124008, Halifax, Nova Scotia
Investigational Site Number : 124005, Kingston, Ontario
Investigational Site Number : 124021, London, Ontario
Investigational Site Number : 124006, Toronto, Ontario
Investigational Site Number : 124009, Toronto, Ontario
Investigational Site Number : 124013, Montreal, Quebec
Investigational Site Number : 124001, Sherbrooke, Quebec
Investigational Site Number : 152004, Antofagasta, Not set
Investigational Site Number : 152001, Coquimbo, Not set
Investigational Site Number : 152003, Iquique, Not set
Investigational Site Number : 152002, Santiago, Not set
Investigational Site Number : 152005, Vallenar, Not set
Investigational Site Number : 153165, Beijing, Not set
Investigational Site Number : 1560003, Hangzhou, Not set
Investigational Site Number : 1560002, Jinan, Not set
Investigational Site Number : 1560004, Nanjing, Not set
Investigational Site Number : 153163, Shanghai, Not set
Investigational Site Number : 170001, Bogotá, Not set
Investigational Site Number : 1910001, Rijena, Not set
Investigational Site Number : 1910002, Zagreb, Not set
Investigational Site Number : 153126, Praha 2, Not set
Investigational Site Number : 153041, Copenhagen, Not set
Investigational Site Number : 151229, København Ø, Not set
Investigational Site Number : 153106, Tartu, Not set
Investigational Site Number : 153024, Turku, Not set
Investigational Site Number : 250005, Bordeaux, Not set
Investigational Site Number : 250002, BRON Cedex, Not set
Investigational Site Number : 250001, Garches, Not set
Investigational Site Number : 250007, Lille, Not set
Investigational Site Number : 250003, Limoges, Not set
Investigational Site Number : 250006, Marseille, Not set
Investigational Site Number : 250004, St-priest-en-jarez, Not set
Investigational Site Number : 250009, Strasbourg, Not set
Investigational Site Number : 153013, Berlin, Not set
Investigational Site Number : 154150, Gießen, Not set
Investigational Site Number : 153147, Münster, Not set
Investigational Site Number : 153011, Würzburg, Not set
Investigational Site Number : 344001, Kowloon, Not set
Investigational Site Number : 3480002, Budapest, Not set
Investigational Site Number : 3480003, Létavértes, Not set
Investigational Site Number : 3480005, Pécs, Not set
Investigational Site Number : 3480004, Sopron, Not set
Investigational Site Number : 356003, Ahmedabad, Not set
Investigational Site Number : 356001, Kolkata, Not set
Investigational Site Number : 3560004, Secunderabad, Not set
Investigational Site Number : 356002, Vellore, Not set
Investigational Site Number : 360001, Jakarta, Not set
Investigational Site Number : 380002, Bassano Del Grappa (VI), Not set
Investigational Site Number : 380004, Firenze, Not set
Investigational Site Number : 380013, Firenze, Not set
Investigational Site Number : 380005, Genova, Not set
Investigational Site Number : 380009, Milano, Not set
Investigational Site Number : 380006, Milano, Not set
Investigational Site Number : 380003, Modena, Not set
Investigational Site Number : 380010, Monza (MB), Not set
Investigational Site Number : 380008, Napoli, Not set
Investigational Site Number : 380007, Rimini, Not set
Investigational Site Number : 380012, Roma, Not set
Investigational Site Number : 380011, Torino, Not set
Investigational Site Number : 380001, Udine, Not set
Investigational Site Number : 380014, Vittoria (RG), Not set
Investigational Site Number : 392007, Kobe, Hyogo
Investigational Site Number : 153201, Nangoku-shi, Kochi
Investigational Site Number : 153205, Abeno-ku, Osaka
Investigational Site Number : 153217, Chiba, Not set
Investigational Site Number : 392006, Niigata, Not set
Investigational Site Number : 153204, Tokyo, Not set
Investigational Site Number : 153178, Yangsan-si, Gyeongsangnam-do
Investigational Site Number : 154148, Yangsan, Gyeongsangnam-do
Investigational Site Number : 154208, Yangsan, Gyeongsangnam-do
Investigational Site Number : 153180, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 153196, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 154246, Busan, Not set
Investigational Site Number : 153191, Daejeon, Not set
Investigational Site Number : 153228, Jeju-si, Not set
Investigational Site Number : 153225, Jeonnam, Not set
Investigational Site Number : 153192, Seoul, Not set
Investigational Site Number : 151149, Seoul, Not set
Investigational Site Number : 153188, Seoul, Not set
Investigational Site Number : 153212, Seoul, Not set
Investigational Site Number : 153222, Seoul, Not set
Investigational Site Number : 154273, Suwon-si, Not set
Investigational Site Number : 154225, Kuwait, Not set
Investigational Site Number : 154244, Vilnius, Not set
Investigational Site Number : 154652, Vilnius, Not set
Investigational Site Number : 458001, Jalan Pahang, Not set
Investigational Site Number : 458002, Kuala Lumpur, Not set
Investigational Site Number : 151171, Amsterdam, Not set
Investigational Site Number : 153004, Amsterdam, Not set
Investigational Site Number : 153141, Bergen, Not set
Investigational Site Number : 604002, Callao, Not set
Investigational Site Number : 608001, Manila, Not set
Investigational Site Number : 150575, Warszawa, Not set
Investigational Site Number : 620005, Lisboa, Not set
Investigational Site Number : 620001, Porto, Not set
Investigational Site Number : 154099, Bucuresti, Not set
Investigational Site Number : 154164, Bucuresti, Not set
Investigational Site Number : 153081, Cluj-napoca, Not set
Investigational Site Number : 643001, Moscow, Not set
Investigational Site Number : 643003, Nizhny Novgorod, Not set
Investigational Site Number : 643002, Saint-Peterburg, Not set
Investigational Site Number : 682002, Al Mubarraz, Not set
Investigational Site Number : 6880001, Novi Sad, Not set
Investigational Site Number : 702001, Singapore, Not set
Investigational Site Number : 703001, Bratislava, Not set
Investigational Site Number : 705001, Slovenj Gradec, Not set
Investigational Site Number : 154146, A Coruña, A Coruña [La Coruña]
Investigational Site Number : 154159, A Coruña, A Coruña [La Coruña]
Investigational Site Number : 153237, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 154147, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 154204, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 154135, Barakaldo, Pais Vasco
Investigational Site Number : 153213, Vigo, Pontevedra [Pontevedra]
Investigational Site Number : 154136, Tarragona, Tarragona [Tarragona]
Investigational Site Number : 153067, Barcelona, Not set
Investigational Site Number : 153077, Barcelona, Not set
Investigational Site Number : 154123, Barcelona, Not set
Investigational Site Number : 153050, Göteborg, Not set
Investigational Site Number : 151484, Stockholm, Not set
Investigational Site Number : 154093, Chiayi, Not set
Investigational Site Number : 152152, Hualien, Not set
Investigational Site Number : 153088, Kaohsiung City, Not set
Investigational Site Number : 152246, Kaohsiung City, Not set
Investigational Site Number : 152244, Kaohsiung, Not set
Investigational Site Number : 151534, New Taipei City, Not set
Investigational Site Number : 151500, Putz City, Chia-yi, Not set
Investigational Site Number : 151179, Taichung, Not set
Investigational Site Number : 151181, Taichung, Not set
Investigational Site Number : 153248, Tainan City, Not set
Investigational Site Number : 152153, Tainan City, Not set
Investigational Site Number : 151182, Taipei City, Not set
Investigational Site Number : 152226, Taipei City, Not set
Investigational Site Number : 152321, Taipei, Not set
Investigational Site Number : 153158, Taoyuan City, Not set
Investigational Site Number : 764003, Bangkok, Not set
Investigational Site Number : 764004, Bangkok, Not set
Investigational Site Number : 764001, Bangkok, Not set
Investigational Site Number : 764005, Khon Kaen, Not set
Investigational Site Number : 151340, Cambridge, Cambridgeshire
Investigational Site Number : 152287, Birmingham, England
Investigational Site Number : 151646, London, London, City Of
Investigational Site Number : 150303, London, London, City Of
Investigational Site Number : 152361, Salford, Manchester
Investigational Site Number : 154196, Belfast, Not set
Investigational Site Number : 151123, London, Not set
Investigational Site Number : 150455, Manchester, Not set
Investigational Site Number : 154212, Hanoi, Not set
Conditions: Fabry Disease
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
Recruiting
Migraine is a disease that most often causes moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms. The goals of the study are to evaluate adverse events and how well treatment of atogepant works compared to placebo (looks like the study treatment but contains no medicine) in preventing chronic migraine in participants between 12 and 17 years of age.
Atogepant... Read More
Migraine is a disease that most often causes moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms. The goals of the study are to evaluate adverse events and how well treatment of atogepant works compared to placebo (looks like the study treatment but contains no medicine) in preventing chronic migraine in participants between 12 and 17 years of age.
Atogepant is a medicine currently approved in the United States and Europe for the preventive treatment of migraine in adult patients with migraine and is being studied for the preventative treatment of chronic migraine in participants between the ages of 12 and 17 years. Participants will be randomly assigned to one of the 2 groups to be treated with either atogepant or placebo. This study is double-blinded, which means that neither the patients nor the study doctors know who is given which study treatment. Approximately 420 participants 12 to 17 years of age with chronic migraine will be enrolled at approximately 70 sites across the world.
Participants will receive oral tablets of atogepant or placebo once daily for 12 weeks and will be followed for 4 weeks.
Participants will attend regular visits during the study at a hospital or clinic and the effects of treatment will be checked by completion of a daily diary, medical assessments, blood tests, checking for side effects, and completing questionnaires. Read Less
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
07/16/2025
Locations: Rehabilitation & Neurological Services /ID# 270782, Huntsville, Alabama +40 locations
Rehabilitation & Neurological Services /ID# 270782, Huntsville, Alabama
Preferred Research Partners /ID# 270389, Little Rock, Arkansas
Preferred Research Partners /ID# 270419, Little Rock, Arkansas
Advanced Research Center /ID# 270257, Anaheim, California
Neuro Pain Medical Center /ID# 271048, Fresno, California
Excell Research /ID# 270258, Oceanside, California
Sunwise Clinical Research /ID# 270431, Walnut Creek, California
Auzmer Research /ID# 271158, Lakeland, Florida
My Preferred Research /ID# 270312, Miami, Florida
Deaconess Midtown Hospital /ID# 270572, Evansville, Indiana
Proven Endpoints LLC /ID# 270269, Ridgeland, Mississippi
Cct Research - Papillion Research Center /ID# 270393, Papillion, Nebraska
Healthy Perspectives - Innovate Mental Health Services /ID# 270847, Nashua, New Hampshire
Dent Neurologic Institute - Amherst /ID# 270260, Amherst, New York
Headache Wellness Center /ID# 270568, Greensboro, North Carolina
Frontier Clinical Research - Scottdale /ID# 270854, Scottdale, Pennsylvania
Frontier Clinical Research - Smithfield /ID# 270849, Smithfield, Pennsylvania
Access Clinical Trials Inc /ID# 270280, Nashville, Tennessee
Earle Research /ID# 270424, Houston, Texas
Clinpoint Trials /ID# 270261, Waxahachie, Texas
Pantheon Clinical Research /ID# 270259, Bountiful, Utah
Highland Clinical Research /ID# 270281, Salt Lake City, Utah
Frontier Clinical Research - Kingwood /ID# 271053, Kingwood, West Virginia
McGill University Health Centre - Glen Site /ID# 270662, Montreal, Quebec
Herlev Hospital /ID# 270482, Herlev, Hovedstaden
Semmelweis Egyetem /ID# 271219, Budapest, Not set
Konan Medical Center /ID# 270486, Kobe-shi, Hyogo
Umenotsuji Clinic /ID# 270484, Kochi-shi, Kochi
Tominaga Clinic /ID# 270483, Osaka-shi, Osaka
Tokyo Headache Clinic /ID# 271610, Shibuya-ku, Tokyo
Tokyo Medical University Hospital /ID# 270487, Shinjuku-ku, Tokyo
Tendo Brain Clinic /ID# 271410, Tendo-shi, Yamagata
Nagaseki Headache Clinic /ID# 271699, Kai, Yamanashi
Tanaka Neurosurgery & Headache Clinic /ID# 271346, Kagoshima, Not set
MIGRE Polskie Centrum Leczenia Migreny /ID# 270239, Wroclaw, Dolnoslaskie
Athleticomed Sp. z o.o /ID# 270243, Bydgoszcz, Kujawsko-pomorskie
Specjalistyczne Gabinety Sp. z o.o /ID# 270238, Krakow, Malopolskie
OHA-MED sp. z o.o /ID# 270242, Warszawa, Mazowieckie
Clinical Research Center Sp. z o.o., Medic-R /ID# 270235, Poznan, Wielkopolskie
Caribbean Medical Research Center /ID# 271300, San Juan, Not set
Royal Aberdeen Children's Hospital /ID# 271664, Aberdeen, Scotland
Conditions: Chronic Migraine
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
Recruiting
This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participants with endocrine-sensitive PIK3CA-mutated hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced breast cancer (ABC).
This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participants with endocrine-sensitive PIK3CA-mutated hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced breast cancer (ABC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia +79 locations
Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia
Springfield Clinic, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Baptist Health Lexington, Lexington, Kentucky
Baptist Health Hamburg, Lexington, Kentucky
Cancer & Hematology Centers of Western Michigan, Grand Rapids, Michigan
Nebraska Cancer Specialists, Grand Island, Nebraska
Nebraska Cancer Specialists, Omaha, Nebraska
West Cancer Center, Germantown, Tennessee
Northwest Medical Specialties, Tacoma, Washington
Centro Oncologico Korben, Caba, Not set
Centro Médico Fleischer, Capital Federal, Not set
Hospital Privado Centro Medico de Cordoba, Cordoba, Not set
Centro Oncológico de Excelencia, San Juan, Not set
Royal North Shore Hospital, St Leonards, New South Wales
Lyell McEwin Hospital, Elizabeth Vale, South Australia
Obras Sociais Irma Dulce - Osid, Salvador, Bahia
Crio - Centro Regional Integrado de Oncologia, Fortaleza, Ceará
Hospital Santa Rita de Cassia Vitoria, Vitoria, Espírito Santo
Hospital Araujo Jorge, Goiania, Goiás
Centro de Oncologia de Alfenas, Alfenas, Minas Gerais
Hospital do Câncer de Londrina, Londrina, Paraná
Hospital do Cancer de Pernambuco - HCP, Recife, Pernambuco
Vencer Oncoclínica - Centro de Pesquisa do Piauí, Teresina, Piauí
Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande Do Sul
Hospital de Cancer de Barretos, Barretos, São Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, São Paulo
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda, Sao Paulo, São Paulo
Instituto Nacional de Cancer - INCa, Rio de Janeiro, Not set
St. Joseph's Health Centre, Toronto, Ontario
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec
Jewish General Hospital, Montreal, Quebec
Unité de Recherche Clinique du CISSS de Laurentides, Saint-jerome, Quebec
Xiangyang Central Hospital, Xiangyang, Hubei
Peking Union Medical College Hospital, Beijing City, Not set
Hunan Cancer Hospital, Changsha CITY, Not set
West China Hospital - Sichuan University, Chengdu City, Not set
Sichuan Provincial People's Hospital, Chengdu, Not set
Sun yat-sen University Cancer Center, Guangzhou, Not set
Sun Yat-Sen University Cancer Center - Huangpu Campus, Guangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou City, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Jiangmen Central Hospital, Jiangmen, Not set
Shandong Cancer Hospital, Jinan, Not set
Jinhua municipal central hospital, Jinhua City, Not set
Yunnan Cancer Hospital, Kunming, Not set
Guangxi Cancer Hospital of Guangxi Medical University, Nanning City, Not set
Shantou Center Hospital, Shantou City, Not set
Tianjin Cancer Hospital, Tianjin, Not set
Tianjin Cancer hospital Airport hospital, Tianjin, Not set
Xinjiang Medical University Cancer Hospital, Urumqi City, Not set
The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an City, Not set
Shanxi Provincial People's Hospital, Xian, Not set
Ospedale Civile - Livorno, Livorno, Toscana
Kyungpook National University Chilgok Hospital, Daegu, Not set
Soon Chun Hyang University Cheonan Hospital, Dongnam-gu, Cheonan-si, Not set
National Cancer Center, Goyang-si, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Gangnam Severance Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Przychodnia Lekarska KOMED, Roman Karaszewski, Konin, Not set
MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie, Rzeszow, Not set
Abraham Oncology, Richards Bay, Not set
Chia-Yi Christian Hospital, Chiayi, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung Uni Hospital, Tainan, Not set
National Taiwan Uni Hospital, Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Abdurrahman Yurtarslan Onkoloji Training and Research Hospital, Ankara, Not set
Ankara City Hospital, Ankara, Not set
Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji, Bakirkoy / Istanbul, Not set
Ba?c?lar Medipol Mega Üniversite Hastanesi, Istanbul, Not set
Katip Celebi University Ataturk Training and Research Hospital, Izmir, Not set
Mersin City Education and Research Hospital, Mersin, Not set
Princess Alexandra Hospital, Harlow, Not set
St Bartholomew's Hospital, London, Not set
Conditions: Breast Cancer
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Recruiting
Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF.
The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full screening assessments. Participants will not be required to visit the site and no informed consent i... Read More
Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF.
The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full screening assessments. Participants will not be required to visit the site and no informed consent is required for the optional pre-screening period. The pre-screening assessments do not replace the full screening tests at Visit 1.
Upon entering the screening period, all consented participants (after signature of screening ICF) will be screened during an up to 14-day screening period. Participants who meet all screening inclusion/exclusion criteria but are not treated with SGLT2i or are treated for less than 4 weeks will enter a run-in period with dapagliflozin 10 mg once daily for at least 4 weeks (and not more than 6 weeks) before randomisation.
Site visits will take place at approximately 2-, 4-, 8-, 16-, and 34-weeks following randomisation. Thereafter visits will occur approximately every 4 months.
The study closure procedures will be initiated when the predetermined number of the first secondary endpoint events (ie, the composite of hospitalisation for HF or CV death) is predicted to have occurred i.e., the PACD.
In case of premature discontinuation of the blinded study intervention, participants will remain in the study. Unless a participant meets the dapagliflozin specific discontinuation criteria, they will continue to receive open label dapagliflozin 10 mg. It is important that the scheduled study visits and data collection continue according to the study protocol. Read Less
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/16/2025
Locations: Research Site, Birmingham, Alabama +850 locations
Research Site, Birmingham, Alabama
Research Site, Centreville, Alabama
Research Site, Fairhope, Alabama
Research Site, Huntsville, Alabama
Research Site, Mobile, Alabama
Research Site, Mobile, Alabama
Research Site, Vestavia Hills, Alabama
Research Site, Gilbert, Arizona
Research Site, Glendale, Arizona
Research Site, Dublin, California
Research Site, Huntington Beach, California
Research Site, Inglewood, California
Research Site, La Jolla, California
Research Site, Lakewood, California
Research Site, Lincoln, California
Research Site, Loma Linda, California
Research Site, San Diego, California
Research Site, San Dimas, California
Research Site, San Francisco, California
Research Site, San Francisco, California
Research Site, Thousand Oaks, California
Research Site, Englewood, Colorado
Research Site, Stamford, Connecticut
Research Site, Waterbury, Connecticut
Research Site, Crystal River, Florida
Research Site, Fort Lauderdale, Florida
Research Site, Fort Myers, Florida
Research Site, Gainesville, Florida
Research Site, Hialeah, Florida
Research Site, Jacksonville, Florida
Research Site, Lakeland, Florida
Research Site, Miami, Florida
Research Site, Miami, Florida
Research Site, Palmetto Bay, Florida
Research Site, Saint Augustine, Florida
Research Site, Albany, Georgia
Research Site, Atlanta, Georgia
Research Site, Canton, Georgia
Research Site, Columbus, Georgia
Research Site, Suwanee, Georgia
Research Site, Woodstock, Georgia
Research Site, Chicago, Illinois
Research Site, Chicago, Illinois
Research Site, Park Ridge, Illinois
Research Site, Indianapolis, Indiana
Research Site, Munster, Indiana
Research Site, South Bend, Indiana
Research Site, El Dorado, Kansas
Research Site, Lenexa, Kansas
Research Site, Newton, Kansas
Research Site, Wichita, Kansas
Research Site, Lexington, Kentucky
Research Site, Paducah, Kentucky
Research Site, Shreveport, Louisiana
Research Site, Baltimore, Maryland
Research Site, Beltsville, Maryland
Research Site, Potomac, Maryland
Research Site, Boston, Massachusetts
Research Site, New Bedford, Massachusetts
Research Site, Roslindale, Massachusetts
Research Site, Troy, Michigan
Research Site, Mankato, Minnesota
Research Site, Minneapolis, Minnesota
Research Site, Columbia, Missouri
Research Site, Kansas City, Missouri
Research Site, Saint Louis, Missouri
Research Site, Missoula, Montana
Research Site, Norfolk, Nebraska
Research Site, Omaha, Nebraska
Research Site, Carson City, Nevada
Research Site, Portsmouth, New Hampshire
Research Site, Somerset, New Jersey
Research Site, Albuquerque, New Mexico
Research Site, Albuquerque, New Mexico
Research Site, Brooklyn, New York
Research Site, Brooklyn, New York
Research Site, Massapequa, New York
Research Site, Charlotte, North Carolina
Research Site, Durham, North Carolina
Research Site, Kernersville, North Carolina
Research Site, Monroe, North Carolina
Research Site, Morehead City, North Carolina
Research Site, New Bern, North Carolina
Research Site, Raleigh, North Carolina
Research Site, Rocky Mount, North Carolina
Research Site, Beavercreek, Ohio
Research Site, Cincinnati, Ohio
Research Site, Cincinnati, Ohio
Research Site, Columbus, Ohio
Research Site, Maumee, Ohio
Research Site, Norman, Oklahoma
Research Site, Grants Pass, Oregon
Research Site, Medford, Oregon
Research Site, Camp Hill, Pennsylvania
Research Site, Horsham, Pennsylvania
Research Site, Scottdale, Pennsylvania
Research Site, Smithfield, Pennsylvania
Research Site, Fort Mill, South Carolina
Research Site, Greenville, South Carolina
Research Site, Mount Pleasant, South Carolina
Research Site, North Charleston, South Carolina
Research Site, Morristown, Tennessee
Research Site, Nashville, Tennessee
Research Site, Abilene, Texas
Research Site, Austin, Texas
Research Site, Beaumont, Texas
Research Site, El Paso, Texas
Research Site, Mesquite, Texas
Research Site, Paris, Texas
Research Site, Pearland, Texas
Research Site, San Antonio, Texas
Research Site, Stephenville, Texas
Research Site, Sugar Land, Texas
Research Site, Woodway, Texas
Research Site, Roy, Utah
Research Site, Burke, Virginia
Research Site, Charlottesville, Virginia
Research Site, Falls Church, Virginia
Research Site, Richmond, Virginia
Research Site, Salem, Virginia
Research Site, Kingwood, West Virginia
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Cordoba, Not set
Research Site, Córdoba, Not set
Research Site, La Plata, Not set
Research Site, Mar del Plata, Not set
Research Site, Mar del Plata, Not set
Research Site, Rosario, Not set
Research Site, Rosario, Not set
Research Site, San Nicolas de los Arroyos, Not set
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Research Site, Calgary, Alberta
Research Site, Calgary, Alberta
Research Site, Sherwood Park, Alberta
Research Site, Surrey, British Columbia
Research Site, Moncton, New Brunswick
Research Site, St. John, New Brunswick
Research Site, St. John's, Newfoundland and Labrador
Research Site, Halifax, Nova Scotia
Research Site, Sydney, Nova Scotia
Research Site, Cambridge, Ontario
Research Site, Guelph, Ontario
Research Site, Hamilton, Ontario
Research Site, Hamilton, Ontario
Research Site, Markham, Ontario
Research Site, Newmarket, Ontario
Research Site, North York, Ontario
Research Site, North York, Ontario
Research Site, Oakville, Ontario
Research Site, Ottawa, Ontario
Research Site, Sarnia, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Laval, Quebec
Research Site, Levis, Quebec
Research Site, Mirabel, Quebec
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Saint-Charles-Borromee, Quebec
Research Site, Sherbrooke, Quebec
Research Site, Terrebonne, Quebec
Research Site, Trois-Rivières, Quebec
Research Site, Regina, Saskatchewan
Research Site, Quebec, Not set
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Research Site, Benesov, Not set
Research Site, Brandys nad Labem, Not set
Research Site, Brno, Not set
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Research Site, Broumov, Not set
Research Site, Chlumec nad Cidlinou, Not set
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Research Site, Jílové u Prahy, Not set
Research Site, Krnov, Not set
Research Site, Olomouc, Not set
Research Site, Ostrava, Not set
Research Site, Plzeň, Not set
Research Site, Police nad Metují, Not set
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Research Site, Praha 10, Not set
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Research Site, Aalborg, Not set
Research Site, Aarhus N, Not set
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Research Site, Frederiksberg, Not set
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Research Site, Bad Homburg, Not set
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Research Site, Bamberg, Not set
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Research Site, Zwenkau, Not set
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Research Site, Jerusalem, Not set
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Research Site, Roma, Not set
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Research Site, Rozzano, Not set
Research Site, Siena, Not set
Research Site, Torino, Not set
Research Site, Udine, Not set
Research Site, Aizu Wakamatsu-shi, Not set
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Research Site, Asahikawa-shi, Not set
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Research Site, Himeji, Not set
Research Site, Itabashi-ku, Not set
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Research Site, Sungai Buloh, Not set
Research Site, Acapulco, Not set
Research Site, Aguascalientes, Not set
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Research Site, Zapopan, Not set
Research Site, Amsterdam, Not set
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Research Site, Den Bosch, Not set
Research Site, Deventer, Not set
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Research Site, Nijmegen, Not set
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Research Site, Angeles City, Not set
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Research Site, Las Pinas, Not set
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Research Site, Puerto Princesa City, Not set
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Research Site, Chrzanów, Not set
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Research Site, Myszków, Not set
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Research Site, Ostrów Mazowiecka, Not set
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Research Site, Przemyśl, Not set
Research Site, Płock, Not set
Research Site, Radzionków, Not set
Research Site, Rzeszów, Not set
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Research Site, Prievidza, Not set
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Research Site, Roznava, Not set
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Research Site, East London, Not set
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Research Site, Lenasia, Not set
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Research Site, Worcester, Not set
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Research Site, Barcelona, Not set
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Research Site, Hospitalet de Llobregat(Barcel, Not set
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Conditions: Heart Failure
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
Recruiting
For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the... Read More
For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the wild-type Huntington (wtHTT) and mutant Huntington (mHTT) alleles. Read Less
Gender:
ALL
Ages:
Between 25 years and 60 years
Trial Updated:
07/16/2025
Locations: Uab Medicine, Birmingham, Alabama +37 locations
Uab Medicine, Birmingham, Alabama
Barrow Neurological Institute, Phoenix, Arizona
University of California San Diego, La Jolla, California
University of California Davis Medical System, Sacramento, California
CenExel Rocky Mountain Clinical Research, LLC, Englewood, Colorado
University of South Florida, Tampa, Florida
Northwestern University, Chicago, Illinois
University of Iowa Hospitals and Clinics, Iowa City, Iowa
John Hopkins University School of Medicine, Baltimore, Maryland
Beth Israel Deaconess Medical Center, Boston, Massachusetts
University of Pittsburgh, Pittsburgh, Pennsylvania
EvergreenHealth Investigational Drug Services, Kirkland, Washington
Hospital Britanico de Buenos Aires, Ciudad Autonoma Buenos Aires, Not set
Calvary Health Care Bethlehem, Caulfield South, New South Wales
Westmead Hospital, Westmead, New South Wales
Royal Melbourne Hospital, Parkville, Victoria
University of Alberta, Edmonton, Alberta
Centricity Research, Halifax, Nova Scotia
North York General Hospital, Toronto, Ontario
McGill University, Montreal, Quebec
Charité - Universitätsmed. Berlin, Klinik für Psychiatrie und Psychotherapie, Berlin, Not set
St. Josef-Hospital, Neurologische Klinik der Ruhr-Uni, Bochum, Not set
Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie, Erlangen, Not set
Universitätsklinikum Ulm, Ulm, Not set
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Lombardia
New Zealand Brain Research Institute, Christchurch, Not set
Wellington Hospital, Wellington, Not set
Szpital Sw. Wojciecha, Gda?sk, Not set
Wojskowy Instytut Medycyny Lotniczej, Warszawa, Not set
Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria, Lisboa, Not set
CNS - Campus Neurológico, Torres Vedras, Not set
Hospital Universitario de Badajoz, Badajoz, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Universitario de Burgos. Servicio de Neurología, Burgos, Not set
Hospital Ramon y Cajal, Madrid, Not set
Birmingham and Solihull Mental Health Foundation NHS Trust, Birmingham, Not set
Addenbrookes Hospital, Cambridge, Not set
National Hospital For Neurology and Neurosurgery, London, Not set
Conditions: Huntington Disease
Evaluation of Maralixibat in Pruritus Associated With General Cholestatic Liver Disease (EXPAND)
Recruiting
The purpose of this study is to determine whether the investigational treatment (maralixibat) is safe and effective in pediatric and adult participants who have cholestatic liver disease with pruritus that has been refractory to other therapies, and who have no other treatment options.
The purpose of this study is to determine whether the investigational treatment (maralixibat) is safe and effective in pediatric and adult participants who have cholestatic liver disease with pruritus that has been refractory to other therapies, and who have no other treatment options. Read Less
Gender:
ALL
Ages:
6 months and above
Trial Updated:
07/16/2025
Locations: Children's Hospital Los Angeles (CHLA), Los Angeles, California +34 locations
Children's Hospital Los Angeles (CHLA), Los Angeles, California
Stanford Children's Health in Palo Alto, Palo Alto, California
Lurie Children's Hospital, Chicago, Illinois
Ochsner Clinic Foundation, New Orleans, Louisiana
NYU Langone Health, New York, New York
Mount Sinai Hospital, New York, New York
Morgan Stanley Children's Hospital - NewYork Presbyterian, New York, New York
Science 37, Inc (Remote-homebase Telemedicine), Morrisville, North Carolina
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Vanderbilt University Medical Center, Nashville, Tennessee
Baylor College of Medicine, Houston, Texas
University of Utah, Salt Lake City, Utah
Seattle Children's Hospital, Seattle, Washington
Hospital de Criança de Brasília (HCB), Brasília, Not set
Hospital da Criança Santo Antonio, Porto Alegre, Not set
Hospital Sírio-Libanês, São Paulo, Not set
Stollery Children's Hospital, Edmonton, Alberta
Hôpital Femme Mère Enfant, Lyon, Not set
Hôpitaux Universitaires de Marseille Timone, Marseille, Not set
Hôpital Kremlin Bicêtre, Paris, Not set
Universitätsklinikum Hamburg Eppendorf - Klinik für Kinder- und Jugendmedizin, Hamburg, Not set
LMU Klinikum - Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, Munich, Not set
Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Not set
ISMETT - Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Not set
Ospedale Pediatrico Bambino Gesu, Rome, Not set
Hotel Dieu de France, Beirut, Not set
Hospital Infantil de México Federico Gómez, Mexico City, Not set
Consultario de Joshue David Covarrubias Esquer, Zapopan, Not set
Instytut Pomnik Centrum Zdrowia Dziecka, Warsaw, Not set
King Faisal Specialist Hospital & Research Center, Riyadh, Not set
Hospital Sant Joan de Deu, Barcelona, Not set
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Hospital Universitario La Paz, Madrid, Not set
King's College Hospital NHS Foundation Trust, London, Not set
Conditions: Cholestatic Liver Disease (except ALGS, PFIC, PBC and PSC)
A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)
Recruiting
The goal of this clinical trial is to assess the efficacy of DB-1303/BNT323 compared with investigator's choice chemotherapy in terms of progression-free survival (PFS) by blinded independent central review (BICR) in the HR+, HER2-low (immunohistochemistry \[IHC\]2+/in situ hybridization \[ISH\]- and IHC 1+) population.
The goal of this clinical trial is to assess the efficacy of DB-1303/BNT323 compared with investigator's choice chemotherapy in terms of progression-free survival (PFS) by blinded independent central review (BICR) in the HR+, HER2-low (immunohistochemistry \[IHC\]2+/in situ hybridization \[ISH\]- and IHC 1+) population. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Research Site 1141-0, Tucson, Arizona +252 locations
Research Site 1141-0, Tucson, Arizona
Research Site 1114-0, Fullerton, California
Research Site 1107-0, Los Angeles, California
Research Site 1118-0, Orange, California
Research Site 1143-0, Sacramento, California
Research Site 1132-0, Santa Barbara, California
Research Site 1137-0, Aurora, Colorado
Research Site 1129-0, Lone Tree, Colorado
Research Site 1154-0, Jacksonville, Florida
Research Site 1145-0, Miami, Florida
Research Site 1150-0, Orange City, Florida
Research Site 1125-0, Palm Bay, Florida
Research Site 1110-0, Savannah, Georgia
Research Site 1124-0, Chicago Ridge, Illinois
Research Site 1147-0, Chicago, Illinois
Research Site 1152-0, Fort Wayne, Indiana
Research Site 1106-0, Merriam, Kansas
Research Site 1104-0, Louisville, Kentucky
Research Site 1122-0, Silver Spring, Maryland
Research Site 8639-0, Silver Spring, Maryland
Research Site 1109-0, Kansas City, Missouri
Research Site 1111-0, Florham Park, New Jersey
Research Site 1157-0, Santa Fe, New Mexico
Research Site 1148-0, Staten Island, New York
Research Site 1105-0, Westbury, New York
Research Site 1144-0, Chapel Hill, North Carolina
Research Site 1138-0, Akron, Ohio
Research Site 1160-0, Cincinnati, Ohio
Research Site 1133-0, Eugene, Oregon
Research Site 1126-0, Tigard, Oregon
Research Site 1134-0, Broomall, Pennsylvania
Research Site 1123-0, Horsham, Pennsylvania
Research Site 1149-0, Knoxville, Tennessee
Research Site 1102-0, Nashville, Tennessee
Research Site 1101-0, Dallas, Texas
Research Site 1116-0, Denison, Texas
Research Site 1115-0, Houston, Texas
Research Site 1117-0, San Antonio, Texas
Research Site 1130-0, Salt Lake City, Utah
Research Site 1108-0, Fairfax, Virginia
Research Site 1131-0, Fairfax, Virginia
Research Site 1127-0, Roanoke, Virginia
Research Site 5411-0, Bahia Blanca, Buenos Aires
Research Site 5414-0, Caba, Buenos Aires
Research Site 5405-0, La Plata, Buenos Aires
Research Site 5413-0, Mar del Plata, Buenos Aires
Research Site 5408-0, Quilmes, Buenos Aires
Research Site 5403-0, Caba, Ciudad Autonoma Buenos Aires
Research Site 5402-0, Viedma, Rio Negro
Research Site 5401-0, Rosario, Santa Fe
Research Site 5406-0, Rosario, Santa Fe
Research Site 5404-0, San Miguel de Tucuman, Tucuman
Research Site 5407-0, Ciudad Autonoma Buenos Aires, Not set
Research Site 5409-0, Ciudad Autonoma Buenos Aires, Not set
Research Site 6108-0, Camperdown, New South Wales
Research Site 6116-0, Kingswood, New South Wales
Research Site 6109-0, Liverpool, New South Wales
Research Site 6102-0, Sydney, New South Wales
Research Site 6106-0, Birtinya, Queensland
Research Site 6101-0, South Brisbane, Queensland
Research Site 6107-0, Southport, Queensland
Research Site 6104-0, Townsville, Queensland
Research Site 6110-0, Adelaide, South Australia
Research Site 6103-0, Bendigo, Victoria
Research Site 6105-0, St. Albans, Victoria
Research Site 6113-0, Traralgon, Victoria
Research Site 6114-0, Perth, Western Australia
Research Site 3201-0, Brussels, Not set
Research Site 3204-0, Gent, Not set
Research Site 3205-0, Jette, Not set
Research Site 3203-0, Leuven, Not set
Research Site 3207-0, Liege, Not set
Research Site 3202-0, Roeselare, Not set
Research Site 1007-0, Winnipeg, Manitoba
Research Site 1003-0, Brampton, Ontario
Research Site 1001-0, Toronto, Ontario
Research Site 1004-0, Montreal, Quebec
Research Site 1005-0, Montreal, Quebec
Research Site 1006-0, Montreal, Quebec
Research Site 1002-0, Sherbrooke, Quebec
Research Site 8640-0, Hefei, Anhui
Research Site 8614-0, Hefei, Anhui
Research Site 8601-0, Beijing, Beijing
Research Site 8625-0, Beijing, Beijing
Research Site 8653-0, Beijing, Beijing
Research Site 8627-0, Chongqing, Chongqing
Research Site 8651-0, Fuzhou, Fujian
Research Site 8638-0, Xiamen, Fujian
Research Site 8630-0, Lanzhou, Gansu
Research Site 8604-0, Guangzhou, Guangdong
Research Site 8628-0, Guangzhou, Guangdong
Research Site 8621-0, Huizhou, Guangdong
Research Site 8622-0, Zhuhai, Guangdong
Research Site 8615-0, Nanning, Guangxi
Research Site, Baoding, Hebei
Research Site 8629-0, Baoding, Hebei
Research Site 8645-0, Shijiazhuang, Hebei
Research Site 8619-0, Harbin, Heilongjiang
Research Site 8649-0, Anyang, Henan
Research Site 8609-0, Luoyang, Henan
Research Site 8648-0, Weihui, Henan
Research Site 8605-0, Zhengzhou, Henan
Research Site 8623-0, Zhengzhou, Henan
Research Site 8637-0, Wuhan, Hubei
Research Site 8608-0, Wuhan, Hubei
Research Site 8633-0, Xiangyang, Hubei
Research Site 8635-0, Changsha, Hunan
Research Site 8654-0, Yongzhou, Hunan
Research Site 8646-0, Huai'an, Jiangsu
Research Site 8607-0, Nanjing, Jiangsu
Research Site 8624-0, Xuzhou, Jiangsu
Research Site 8631-0, Nanchang, Jiangxi
Research Site 8612-0, Changchun, Jilin
Research Site 8618-0, Changchun, Jilin
Research Site 8644-0, Changchun, Jilin
Research Site 8636-0, Dalian, Liaoning
Research Site-8636-0, Dalian, Liaoning
Research Site 8643-0, Shenyang, Liaoning
Research Site 8642-0, Shenyang, Liaoning
Research Site 8634-0, Jinan, Shandong
Research Site 8613-0, Jining, Shandong
Research Site 8610-0, Linyi, Shandong
Research Site 8650-0, Weihai, Shandong
Research Site 8603-0, Shanghai, Shanghai
Research Site 8602-0, Shanghai, Shanghai
Research Site 8611-0, Xi'an, Shanxi
Research Site 8606-0, Chengdu, Sichuan
Research Site 8626-0, Neijiang, Sichuan
Research Site 8647-0, Zigong, Sichuan
Research Site 8617-0, Tianjin, Tianjin
Research Site 8616-0, Urumqi, Xinjiang
Research Site 8632-0, Kunming, Yunnan
Research Site 8652-0, Hangzhou, Zhejiang
Research Site 8620-0, Hangzhou, Zhejiang
Research Site 8641-0, Hangzhou, Zhejiang
Research Site 3311-0, Marseille cedex 20, Bouches-du-Rhône
Research Site 3303-0, La Rochelle cedex, Charente Maritime
Research Site 3312-0, Besancon Cedex, Doubs
Research Site 3308-0, Nimes, Gard
Research Site 3314-0, Bordeaux, Gironde
Research Site 3305-0, Toulouse cedex 09, Haute Garonne
Research Site 3309-0, Limoges, Haute Vienne
Research Site 3304-0, Montpellier, Herault
Research Site 3310-0, Saint Herblain, Loire Atlantique
Research Site 3301-0, Angers Cedex 2, Maine Et Loire
Research Site 3315-0, Lille cedex, Nord
Research Site 3306-0, Bayonne cedex, Pyrenees Atlantiques
Research Site 3318-0, Pierre Benite cedex, Rhone
Research Site 3313-0, Rouen, Seine Maritime
Research Site 3307-0, Avignon Cedex 9, Vaculuse
Research Site 3302-0, Creteil Cedex, Val De Marne
Research Site 3316-0, Paris, Not set
Research Site 4907-0, Erlangen, Bayern
Research Site 4909-0, Wiesbaden, Hessen
Research Site 4904-0, Bottrop, Nordrhein Westfalen
Research Site 4901-0, Witten, Nordrhein Westfalen
Research Site 4903-0, Dresden, Sachsen
Research Site 4905-0, Berlin, Not set
Research Site 4906-0, Berlin, Not set
Research Site 8504-0, Hong Kong, Not set
Research Site 8501-0, Hong Kong, Not set
Research Site 8503-0, Hong Kong, Not set
Research Site 8502-0, Hong Kong, Not set
Research Site 8505-0, Hong Kong, Not set
Research Site 3603-0, Budapest, Not set
Research Site 3606-0, Gyor, Not set
Research Site 3604-0, Kecskemet, Not set
Research Site 3602-0, Salgotarjan, Not set
Research Site 3607-0, Tatabanya, Not set
Research Site 3605-0, Zalaegerszeg, Not set
Research Site 9710-0, Ashdod, Not set
Research Site 9706-0, Haifa, Not set
Research Site 9708-0, Haifa, Not set
Research Site 9702-0, Jerusalem, Not set
Research Site 9707-0, Jerusalem, Not set
Research Site 9703-0, Kfar-Saba, Not set
Research Site 9704-0, Petach-Tikva, Not set
Research Site 9709-0, Ramat-Gan, Not set
Research Site 9705-0, Rehovot, Not set
Research Site 9701-0, Tel Aviv, Not set
Research Site 3908-0, Bergamo, Not set
Research Site 3907-0, Brescia, Not set
Research Site 3901-0, Catania, Not set
Research Site 3903-0, Catanzaro, Not set
Research Site 3906-0, Milano, Not set
Research Site 3911-0, Milano, Not set
Research Site 3904-0, Milano, Not set
Research Site 3909-0, Napoli, Not set
Research Site 3902-0, Pavia, Not set
Research Site 3905-0, Verona, Not set
Research Site 8211-0, Wonju, Gangwon-do
Research Site 8204-0, Seongnam, Gyeonggi-do
Research Site 8201-0, Seoul, Gyeonggi-do
Research Site 8202-0, Suwon, Gyeonggi-do
Research Site 8208-0, Busan, Not set
Research Site 8212-0, Cheonan, Not set
Research Site 8209-0, Incheon, Not set
Research Site 8207-0, Seoul, Not set
Research Site 8213-0, Seoul, Not set
Research Site 8206-0, Seoul, Not set
Research Site 8210-0, Seoul, Not set
Research Site 8203-0, Seoul, Not set
Research Site 8205-0, Seoul, Not set
Research Site 8214-0, Ulsan, Not set
Research Site 4804-0, Krakow, Not set
Research Site 4801-0, Poznan, Not set
Research Site 4802-0, Rzeszów, Not set
Research Site 4807-0, Torun, Not set
Research Site 4805-0, Warszawa, Not set
Research Site 4809-0, Wroclaw, Not set
Research Site 4803-0, Łódź, Not set
Research Site 3403-0, Sant Cugat del Valles, Barcelona
Research Site 3409-0, Santiago de Compostela, La Coruña
Research Site 3406-0, Majadahonda, Madrid
Research Site 3411-0, Pozuelo de Alarcon, Madrid
Research Site 3405-0, Pamplona, Navarra
Research Site 3410-0, Barcelona, Not set
Research Site 3402-0, Barcelona, Not set
Research Site 3404-0, Barcelona, Not set
Research Site 3416-0, Madrid, Not set
Research Site 3407-0, Madrid, Not set
Research Site 3414-0, Madrid, Not set
Research Site 3401-0, Madrid, Not set
Research Site 3418-0, Malaga, Not set
Research Site 3415-0, Málaga, Not set
Research Site 3408-0, Sevilla, Not set
Research Site 3413-0, Sevilla, Not set
Research Site 3417-0, Sevilla, Not set
Research Site 3412-0, Valencia, Not set
Research Site 9001-0, Adana, Not set
Research Site 9002-0, Ankara, Not set
Research Site 9006-0, Ankara, Not set
Research Site 9003-0, Ankara, Not set
Research Site 9004-0, Ankara, Not set
Research Site 9009-0, Diyarbakir, Not set
Research Site 9008-0, Istanbul, Not set
Research Site 9010-0, Izmir, Not set
Research Site 9007-0, Samsun, Not set
Research Site 4404-0, Truro, Cornwall
Research Site 4408-0, London, Greater London
Research Site 4411-0, London, Greater London
Research Site 4406-0, London, Greater London
Research Site 4416-0, London, Greater London
Research Site 4409-0, London, Greater London
Research Site 4402-0, Manchester, Greater Manchester
Research Site 4415-0, Maidstone, Kent
Research Site 4414-0, Bath, Somerset
Research Site 4410-0, Cardiff, South Glamorgan
Research Site 4405-0, Glasgow, Strathclyde
Research Site 4416-A, Sutton, Surrey
Research Site 4407-0, Leeds, West Yorkshire
Research Site 4403-0, Middlesex, Not set
Research Site 4401-0, Nottingham, Not set
Conditions: Metastatic Breast Cancer
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer
Recruiting
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, wor... Read More
This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The purpose of this study is to compare the usual treatment (radiation therapy with cisplatin chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy, and using the usual treatment plus an immunotherapy drug, atezolizumab. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +325 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
The Kirklin Clinic at Acton Road, Birmingham, Alabama
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California
Mercy San Juan Medical Center, Carmichael, California
UC San Diego Health System - Encinitas, Encinitas, California
UC San Diego Moores Cancer Center, La Jolla, California
Cedars Sinai Medical Center, Los Angeles, California
Memorial Medical Center, Modesto, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Saint Helena Hospital, Saint Helena, California
UCSF Medical Center-Mount Zion, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Mills Health Center, San Mateo, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
AdventHealth Porter, Denver, Colorado
Shaw Cancer Center, Edwards, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado
Longmont United Hospital, Longmont, Colorado
Banner McKee Medical Center, Loveland, Colorado
AdventHealth Parker, Parker, Colorado
University of Connecticut, Farmington, Connecticut
Yale University, New Haven, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Helen F Graham Cancer Center, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
George Washington University Medical Center, Washington, District of Columbia
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Holy Cross Hospital, Fort Lauderdale, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Moffitt Cancer Center, Tampa, Florida
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Queen's Medical Center, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho
Northwestern University, Chicago, Illinois
John H Stroger Jr Hospital of Cook County, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Crossroads Cancer Center, Effingham, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Ascension Saint Vincent Anderson, Anderson, Indiana
Elkhart General Hospital, Elkhart, Indiana
Radiation Oncology Associates PC, Fort Wayne, Indiana
Parkview Hospital Randallia, Fort Wayne, Indiana
Parkview Regional Medical Center, Fort Wayne, Indiana
Goshen Center for Cancer Care, Goshen, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
IU Health Methodist Hospital, Indianapolis, Indiana
IU Health Central Indiana Cancer Centers-East, Indianapolis, Indiana
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana
Memorial Hospital of South Bend, South Bend, Indiana
McFarland Clinic - Ames, Ames, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Tulane University School of Medicine, New Orleans, Louisiana
University Medical Center New Orleans, New Orleans, Louisiana
Touro Infirmary, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
Central Maryland Radiation Oncology in Howard County, Columbia, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
Holy Cross Hospital, Silver Spring, Maryland
Boston Medical Center, Boston, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
University of Michigan - Brighton Center for Specialty Care, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Henry Ford Hospital, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Allegiance Health, Jackson, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
University of Michigan Health - West, Wyoming, Michigan
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Miller-Dwan Hospital, Duluth, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Saint Francis Medical Center, Cape Girardeau, Missouri
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
North Kansas City Hospital, Kansas City, Missouri
The University of Kansas Cancer Center-South, Kansas City, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
CHI Health Good Samaritan, Kearney, Nebraska
Nebraska Methodist Hospital, Omaha, Nebraska
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
The Cancer Institute of New Jersey Hamilton, Hamilton, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Virtua Memorial, Mount Holly, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
Sparta Cancer Treatment Center, Sparta, New Jersey
Community Medical Center, Toms River, New Jersey
Virtua Voorhees, Voorhees, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
New Mexico Oncology Hematology Consultants, Albuquerque, New Mexico
South Shore University Hospital, Bay Shore, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
NYU Langone Hospital - Brooklyn, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Sands Cancer Center, Canandaigua, New York
Memorial Sloan Kettering Commack, Commack, New York
Arnot Ogden Medical Center/Falck Cancer Center, Elmira, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
NYU Langone Hospital - Long Island, Mineola, New York
Mount Sinai Union Square, New York, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Wilmot Cancer Institute Radiation Oncology at Greece, Rochester, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow, New York
State University of New York Upstate Medical University, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Atrium Health Stanly/LCI-Albemarle, Albemarle, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Atrium Health Pineville/LCI-Pineville, Charlotte, North Carolina
Atrium Health University City/LCI-University, Charlotte, North Carolina
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina
East Carolina University, Greenville, North Carolina
ECU Health Oncology Kinston, Kinston, North Carolina
Atrium Health Union/LCI-Union, Monroe, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Cleveland Clinic Akron General, Akron, Ohio
UH Seidman Cancer Center at UH Avon Health Center, Avon, Ohio
Summa Health System - Barberton Campus, Barberton, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Geauga Hospital, Chardon, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Mercy Cancer Center-Elyria, Elyria, Ohio
Cleveland Clinic Cancer Center Independence, Independence, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
Summa Health Medina Medical Center, Medina, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio
University Hospitals Parma Medical Center, Parma, Ohio
Southern Ohio Medical Center, Portsmouth, Ohio
University Hospitals Portage Medical Center, Ravenna, Ohio
North Coast Cancer Care, Sandusky, Ohio
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Clackamas Radiation Oncology Center, Clackamas, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
UPMC Altoona, Altoona, Pennsylvania
UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
IRMC Cancer Center, Indiana, Pennsylvania
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania
UPMC Cancer Center at UPMC McKeesport, McKeesport, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center in Coraopolis, Moon, Pennsylvania
UPMC Cancer Center-Natrona Heights, Natrona Heights, Pennsylvania
UPMC Jameson, New Castle, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Temple University Hospital, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Margaret, Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
UPMC Jefferson Regional Radiation Oncology, Pittsburgh, Pennsylvania
UPMC-Passavant Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania
UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania
UPMC Uniontown Hospital Radiation Oncology, Uniontown, Pennsylvania
UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Wexford Health and Wellness Pavilion, Wexford, Pennsylvania
AnMed Health Cancer Center, Anderson, South Carolina
Saint Joseph's/Candler - Bluffton Campus, Bluffton, South Carolina
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Prisma Health Cancer Institute - Greer, Greer, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
Rock Hill Radiation Therapy Center, Rock Hill, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
MD Anderson in The Woodlands, Conroe, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
University of Texas Medical Branch, Galveston, Texas
M D Anderson Cancer Center, Houston, Texas
MD Anderson West Houston, Houston, Texas
MD Anderson League City, League City, Texas
UTMB Cancer Center at Victory Lakes, League City, Texas
Covenant Medical Center-Lakeside, Lubbock, Texas
MD Anderson in Sugar Land, Sugar Land, Texas
Intermountain Medical Center, Murray, Utah
Saint George Regional Medical Center, Saint George, Utah
Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Sentara Cancer Institute at Sentara CarePlex Hospital, Hampton, Virginia
Sentara Norfolk General Hospital, Norfolk, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Sentara Virginia Beach General Hospital, Virginia Beach, Virginia
Saint Francis Hospital, Federal Way, Washington
Tri-Cities Cancer Center, Kennewick, Washington
PeaceHealth Saint John Medical Center, Longview, Washington
Skagit Regional Health Cancer Care Center, Mount Vernon, Washington
University of Washington Medical Center - Montlake, Seattle, Washington
Spokane Valley Cancer Center-Mayfair, Spokane, Washington
Spokane Valley Cancer Center-Mission, Spokane, Washington
Wenatchee Valley Hospital and Clinics, Wenatchee, Washington
West Virginia University Healthcare, Morgantown, West Virginia
Camden Clark Medical Center, Parkersburg, West Virginia
Wheeling Hospital/Schiffler Cancer Center, Wheeling, West Virginia
Langlade Hospital and Cancer Center, Antigo, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Bay Area Medical Center, Marinette, Wisconsin
Marshfield Medical Center, Marshfield, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
Cancer Center of Western Wisconsin, New Richmond, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Cross Cancer Institute, Edmonton, Alberta
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Chinese University of Hong Kong-Prince of Wales Hospital, Shatin, Not set
Conditions: Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7, Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7, Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma
A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)
Recruiting
Researchers are looking for new ways to treat people with high-risk muscle-invasive urothelial carcinoma (MIUC). Urothelial carcinoma is a type of bladder cancer that begins in cells that line the inside of the bladder and other parts of the urinary tract, such as part of the kidneys, ureters, and urethra. People with MIUC usually have chemotherapy before surgery, then surgery to remove the cancer. Chemotherapy is a type of medicine to destroy cancer cells or stop them from growing. After surger... Read More
Researchers are looking for new ways to treat people with high-risk muscle-invasive urothelial carcinoma (MIUC). Urothelial carcinoma is a type of bladder cancer that begins in cells that line the inside of the bladder and other parts of the urinary tract, such as part of the kidneys, ureters, and urethra. People with MIUC usually have chemotherapy before surgery, then surgery to remove the cancer. Chemotherapy is a type of medicine to destroy cancer cells or stop them from growing. After surgery, some people receive more treatment to prevent cancer from returning. Pembrolizumab is an immunotherapy, which is a treatment that helps the immune system fight cancer. Enfortumab vedotin (EV) is an antibody drug conjugate (ADC). An ADC attaches to a protein on cancer cells and delivers treatment to destroy those cells. Researchers want to learn if giving intismeran autogene (the study treatment) with pembrolizumab can prevent MIUC from returning after surgery. Intismeran autogene (also called mRNA-4157) is designed to treat each person's cancer by helping the person's immune system identify and kill cancer cells based on certain proteins found on those cancer cells.
The goals of this study are to learn if people who receive intismeran autogene and pembrolizumab are alive and cancer free longer than those who receive placebo and pembrolizumab, and to learn about the safety of intismeran autogene, pembrolizumab, and EV, and if people tolerate them. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro ( Site 0104), Los Angeles, California +73 locations
UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro ( Site 0104), Los Angeles, California
AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlandoc ( Site 0102), Orlando, Florida
University of Chicago Medical Center ( Site 0109), Chicago, Illinois
University of Iowa ( Site 0110), Iowa City, Iowa
Icahn School of Medicine at Mount Sinai ( Site 0101), New York, New York
Duke Cancer Institute ( Site 0107), Durham, North Carolina
Cleveland Clinic Main ( Site 0100), Cleveland, Ohio
Fox Chase Cancer Center ( Site 0106), Philadelphia, Pennsylvania
UT Southwestern Medical Center ( Site 0103), Dallas, Texas
Houston Methodist Hospital-Department of Urology ( Site 0111), Houston, Texas
Macquarie University-MQ Health Clinical Trials Unit ( Site 1803), Macquarie University, New South Wales
Westmead Hospital ( Site 1802), Westmead, New South Wales
Mater Misericordiae Limited ( Site 1808), South Brisbane, Queensland
One Clinical Research ( Site 1807), Nedlands, Western Australia
BC Cancer Vancouver ( Site 0004), Vancouver, British Columbia
Princess Margaret Cancer Centre ( Site 0003), Toronto, Ontario
Centre Hospitalier de l'Université de Montréal ( Site 0005), Montréal, Quebec
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0001), Quebec City, Quebec
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0002), Sherbrooke, Quebec
CIDO SpA ( Site 1509), Temuco, Araucania
Bradfordhill-Clinical Area ( Site 1501), Recoleta, Santiago, Region M. De Santiago
FALP ( Site 1500), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile ( Site 1503), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 1506), Viña del Mar, Valparaiso
Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 1605), Valledupar, Cesar
Instituto Nacional De Cancerologia-Oncología Clínica ( Site 1606), Bogota, Cundinamarca
Clínica Universitaria Colombia ( Site 1600), Bogotá, Distrito Capital De Bogota
Fundacion Valle del Lili- CIC-Oncology CIC ( Site 1608), Cali, Valle Del Cauca
Oncopole Claudius Regaud ( Site 0302), Toulouse, Haute-Garonne
Gustave Roussy ( Site 0303), Villejuif, Ile-de-France
Institut de Cancérologie de l'Ouest ( Site 0300), ANGERS cedex 02, Maine-et-Loire
Hopital Claude Huriez - CHU de Lille ( Site 0301), Lille, Nord
Hôpital Saint-Louis ( Site 0304), Paris, Not set
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0401), Munich, Bayern
Caritas-Krankenhaus St. Josef-Klinik fuer Urologie ( Site 0404), Regensburg, Bayern
Universitätsklinikum Halle-Universitätsklinik und Poliklinik für Urologie ( Site 0402), Halle, Sachsen-Anhalt
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Urologie ( Site 0405), Dresden, Sachsen
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0400), Berlin, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 0504), Roma, Lazio
Ospedale San Martino-U.O. Oncologia Medica 1 ( Site 0500), Genova, Liguria
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0502), Milan, Lombardia
Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli-UOSC Oncologia ( Site 0503), Naples, Napoli
Ospedale San Raffaele-Oncologia Medica ( Site 0501), Milano, Not set
Korea University Anam Hospital ( Site 2002), Seoul, Not set
Seoul National University Hospital-Urology ( Site 2000), Seoul, Not set
Samsung Medical Center-Urology ( Site 2001), Seoul, Not set
Auckland City Hospital ( Site 1901), Auckland, Not set
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 1702), Lima, Not set
Oncosalud ( Site 1701), Lima, Not set
Hospital Militar Central Luis Arias Schereiber ( Site 1700), Lima, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 0801), Bydgoszcz, Kujawsko-pomorskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Moczowego ( Site 0800), Warszawa, Mazowieckie
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej ( Site 0806), Kielce, Swietokrzyskie
Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k ( Site 0805), Poznan, Wielkopolskie
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0802), Koszalin, Zachodniopomorskie
Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 1006), Badalona, Barcelona
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1005), Madrid, Madrid, Comunidad De
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 1003), Pozuelo de Alarcon, Madrid
Hospital Universitari Vall d'Hebron-Oncology ( Site 1002), Barcelona, Not set
HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 1001), Sevilla, Not set
Karolinska Universitetssjukhuset Solna ( Site 1101), Stockholm, Stockholms Lan
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1102), Uppsala, Uppsala Lan
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1200), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 1204), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1201), Ankara, Not set
Koc Universitesi Hastanesi ( Site 1206), Istanbul, Not set
T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training ( Site 1205), Istanbul, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1202), Istanbul, Not set
Ege Universitesi Hastanesi-Medical Oncology ( Site 1203), Izmir, Not set
Torbay Hospital ( Site 1303), Torquay, Devon
Royal Free Hospital ( Site 1300), London, England
Gartnavel General Hospital-Clinical Trials Unit ( Site 1301), Glasgow, Glasgow City
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1302), London, London, City Of
The Christie NHS Foundation Trust ( Site 1306), Manchester, Not set
Conditions: Bladder Cancer
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