All Clinical Trials in Canada

A listing of 3914 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

NCT06112314

Recruiting

This is a phase 3, randomized, controlled study of brenetafusp (IMC-F106C) plus nivolumab compared to standard nivolumab regimens in HLA-A\*02:01-positive participants with previously untreated advanced melanoma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: University of Arizona, Tucson, Arizona +173 locations

University of Arizona, Tucson, Arizona

University of California - San Diego, La Jolla, California

The Angeles Clinic and Research Institute- West Los Angeles, Los Angeles, California

ESC Norris Comprehensive Cancer Center, Los Angeles, California

UCLA Hematology/Oncology, Los Angeles, California

Stanford Cancer Institute - Stanford Cancer Center Palo Alto, Palo Alto, California

Saint John's Health Center - John Wayne Cancer Institute (JWCI), Santa Monica, California

University of Colorado, Anschutz Medical Campus, Aurora, Colorado

UConn Health-Farmington (University of Connecticut Health Center (UCHC)), Farmington, Connecticut

Georgetown University, Washington, District of Columbia

Mayo Clinic Florida, Jacksonville, Florida

University of Miami Health System-Sylvester Comprehensive Cancer Center-Miami, Miami, Florida

Northwestern University - Robert H. Lurie Comprehensive Cancer Center - NMDTI, Chicago, Illinois

The University of Kansas Cancer Center (KUCC) - Westwood, Westwood, Kansas

St. Elizabeth Healthcare - Edgewood, Edgewood, Kentucky

Dana Farber Cancer Institute, Boston, Massachusetts

Washington University School of Medicine, Saint Louis, Missouri

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey

Northwell Health Cancer Institute, Lake Success, New York

Columbia University Medical Center, New York, New York

Thomas Jefferson University, Philadelphia, Pennsylvania

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

Prisma Health Cancer Institute, Greenville, South Carolina

Spartanburg Regional Healthcare System - Spartanburg Medical Center (SMC), Spartanburg, South Carolina

Sarah Cannon Research Institute: USA/TN, Nashville, Tennessee

University of Utah Huntsman Cancer Institute, Salt Lake City, Utah

UVA Health-UVA Emily Couric Clinical Cancer Center, Charlottesville, Virginia

Swedish Medical Center - Swedish Cancer Institute (SCI) - First Hill Campus, Seattle, Washington

Sanatorio Finochietto, Caba, Buenos Aires

Clínica Adventista Belgrano - Sector Investigación, Caba, Buenos Aires

Instituto Alexander Fleming, Caba, Not set

CEMAIC (Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Córdoba, Not set

Clinica Viedma, Viedma, Not set

Calvary Mater Newcastle Hospital, Waratah, New South Wales

Gallipoli Medical Research Foundation (Greenslopes Private Hospital), Greenslopes, Queensland

Linear Clinical Research, Nedlands, Western Australia

One Clinical Research - Nedlands, Nedlands, Western Australia

Austin Hospital, Heidelberg, Not set

Peter MacCallum Cancer Centre, North Melbourne, Not set

University of Sydney - Melanoma Institute Australia (MIA) - The Poche Centre, Wollstonecraft, Not set

The University of Queensland (UQ) - Princess Alexandra Hospital (PAH), Woolloongabba, Not set

LKH - Universitaetsklinikum Graz, Graz, Not set

Universitätsklinikum St. Pölten, Pölten, Not set

Paracelsus Medizinischen Privatuniversitaet - SALK - Universitaetsklinik fuer Dermatologie - EB-Haus Austria, Salzburg, Not set

Universite Libre de Bruxelles (ULB)-Institut Jules Bordet, Anderlecht, Not set

AZ Sint-Jan Brugge-Oostende AV-Campus Sint-Jan, Brugge, Not set

Universitair Ziekenhuis Brussel, Brussel, Not set

Cliniques Universitaires Saint-Luc - Institut Roi Albert II, Bruxelles, Not set

UZ Leuven, Leuven, Not set

Centro de Pesquisa Clinica em Oncologia - Oncosite, Ijuí, RS

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa Ltda, Porto Alegre, RS

Fundacao Pio XII - Hospital de Cancer de Barretos - Hospital de Amor, Barretos, Not set

Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia, Brasília, Not set

Centro de Pesquisas Oncologicas (CEPON), Florianópolis, Not set

Oncocentro Sao Carlos Hospital, Fortaleza, Not set

A.C.Camargo Cancer Center - Centro Internacional de Pesquisa (CIPE), Liberdade, Not set

Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Not set

Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) - Hospital Sao Lucas - Centro de Pesquisa Clinica (CPC), Porto Alegre, Not set

National Cancer Institute, Rio De Janeiro, Not set

Instituto Américas - Instituto de Educação Pesquisa e Gestão em Saúde Oncosite, Rio De Janeiro, Not set

Instituto do Cancer do Estado de Sao Paulo (ICESP), São Paulo, Not set

Hospital 9 de Julho, São Paulo, Not set

Faculdade de Medicina de Sao Jose do Rio Preto-SP (FAMERP) - Hospital de Base (HB) - Centro Integrado de Pesquisa (CIP), São Paulo, Not set

Uni Hospital, Panagyurishte, Not set

Complex Oncology Center - Plovdiv Ltd., Plovdiv, Not set

University Hospital Tsaritsa Yoanna (ISUL) (Queen Giovanna University Hospital), Sofia, Not set

Regina Life Clinic, Sofia, Not set

Princess Margaret Cancer Centre, Toronto, Ontario

Cross Cancer Institute, Edmonton, Not set

Fakultni Nemocnice Hradec Kralove (FNHK) - Klinika Onkologie a Radioterapie, Hradec Králové, Not set

Fakultni Nemocnice Olomouc (FNOL), Olomouc, Not set

Sanatorium Profesora Arenbergera, Praha, Not set

Kobenhavns Universitet - Herlev Hospital (Amtssygehuset i Herlev), Herlev, Not set

Hôpital de la Timone, Marseille, Cedex

Oncopole Claudius Regaud- Institut Universitaire du Cancer de Toulouse, Toulouse, Cedex

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopitaux Universitaires Paris Seine-Saint-Denis - Hopital Avicenne, Bobigny, Not set

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Ambroise-Pare, Boulogne-Billancourt, Not set

UNICANCER-Centre Francois Baclesse (CFB), Caen, Not set

CHU de Dijon Bourgogne - Hôpital François Mitterrand, Dijon, Not set

Centre Hospitalier Universitaire de Lille (CHU Lille)-Hopital Claude Huriez, Lille, Not set

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu, Nantes, Not set

Hospital Saint Louis, Paris, Not set

Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud, Pierre-Benite, Not set

Centre Hospitalier Universitaire de Rouen (CHU de Rouen) - Hopital Charles-Nicolle, Rouen, Not set

Hopital Robert Debre, Valence, Not set

Institut Gustave Roussy (IGR) Service de Dermatolgie, Villejuif, Not set

Charite-Universitaetsmedizin Berlin - Campus Charite Mitte (CCM) - Klinik fuer Dermatologie Venerologie und Allergologie - Hauttumorcentrum Charite (HTCC), Berlin, Not set

Universitätsklinikum Carl Gustav Carus, Dresden, Not set

Helios Klinikum Erfurt - Klinik fuer Hautkrankheiten und Allergologie, Erfurt, Not set

Universitaetsklinikum Essen, Essen, Not set

Johann Wolfgang Goethe-Universitaet Frankfurt am Main - Klinik fuer Dermatologie, Venerologie und Allergologie, Frankfurt, Not set

Justus-Liebig-Universitaet Giessen - Klinik fuer Dermatologie und Andrologie, Gießen, Not set

University of Hamburg, Hamburg, Not set

Elbe Kliniken Stade - Hautkrebszentrum Buxtehude, Hamburg, Not set

Universitaetsklinikum Heidelberg (UKHD) - Hautklinik, Heidelberg, Not set

Universitaetsklinikum Leipzig - Klinik fuer Dermatologie, Venerologie und Allergologie, Leipzig, Not set

Johannes Wesling Klinikum Minden, Minden, Not set

LMU Klinikum - Klinik und Poliklinik fur Dermatologie und Allergologie, Munich, Not set

Universitaetsklinikum Tuebingen (UKT) - Zentrum fuer Dermatoonkologie - Hautklinik, Tübingen, Not set

Universitaetsklinikum Wuerzburg - Klinik und Poliklinik fuer Dermatologie Venerologie und Allergologie, Würzburg, Not set

Semmelweis Egyetem Általános Orvostudományi Kar, Budapest, Not set

Pecsi Tudomanyegyetem (PTE) (University of Pecs), Pécs, Not set

Szegedi Tudomanyegyetem (University of Szeged), Szeged, Not set

Istituto Tumori Giovanni Paolo II - Ospedale Oncologico di Bari, Bari, Not set

Humanitas Gavazzeni (Cliniche Gavazzeni S.p.A), Bergamo, Not set

IRCCS Istituto Scientifico Romagnolo per lo Studio dei Tumori "Dino Amadori" Srl (IRST), Meldola, Not set

Fondazione IRCCS - Istituto Nazionale dei Tumori - Milano, Milano, Not set

Istituto Europeo di Oncologia (IEO) (European Institute of Oncology), Milan, Not set

Istituto Nazionale Tumori (INT) "Fondazione G. Pascale" di Napoli, Napoli, Not set

Istituto Oncologico Veneto (IOV) IRCCS, Padova, Not set

Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia, Perugia, Not set

Azienda Sanitaria Locale di Biella (ASL BI) - Ospedale degli Infermi, Ponderano, Not set

National Cancer Institute Regina Elena, Roma, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Not set

" Azienda Ospedaliera Universitaria Senese - Policlinico Santa Maria Alle Scotte - Clinica Immunoterapia Oncologica", Siena, Not set

Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino, Torino, Not set

Haukeland University Hospital, Bergen, Not set

Oslo University Hospital, Oslo, Not set

Centrum Onkologii im. Prof. Franciszka Łukaszczyka, Bydgoszcz, Not set

Klinika Onkologii i Radioterapii Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

Centrum Medyczne Pratia Poznań - Skorzewo, Skorzewo, Not set

Klinika Nowotworów Tkanek Miękkich, Kości i Czerniaków, Warszawa, Not set

L'Institute Oncologique Prof. Dr. Ion Chiricuta (IOCN) (The Oncology Institute Prof. Dr. Ion. Chiricuta), Cluj-Napoca, Not set

Sf Nectarie Oncology Center, Craiova, Not set

Victoria Hospital (Centrul de oncologie Euroclinic SRL) (Centrul De Oncologie Medicala) (Euroclinic Onchology Center), Iaşi, Not set

Universidad de Cantabria (UC) - Hospital Universitario Marques de Valdecilla (HUMV), Santander, Cantabria

Universidad de Murcia - Hospital Universitario Virgen de la Arrixaca (HUVA), El Palmar, Murcia

Complejo Hospitalario Universitario A Coruna (CHUAC), A Coruña, Not set

Hospital Universitari Vall d'Hebron, Barcelona, Not set

Hospital Universitario Dexeus, Barcelona, Not set

Hospital Duran i Reynals, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Universitario Reina Sofia, Córdoba, Not set

Hospital Universitario Virgen de las Nieves (HUVN), Granada, Not set

Hospital General Universitario Gregorio Marañon, Madrid, Not set

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Madrid, Madrid, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

Universidad Complutense de Madrid (UCM)-Hospital Universitario 12 de Octubre (H12O), Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Centro Integral Oncologico Clara Campal (CIOCC), Madrid, Not set

Hospital Regional Universitario de Malaga, Málaga, Not set

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Pamplona, Pamplona, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

Hospital Universitario Virgen Macarena, Seville, Not set

Instituto de Investigacion Sanitaria (INCLIVA) (Institute of Health Research Hospital Clinic of Valencia), Valencia, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia, Not set

Servicio Aragones de Salud - Hospital Universitario Miguel Servet (HUMS), Zaragoza, Not set

Sahlgrenska Akademin - Institutionen for Kliniska Vetenskaper (Institute of Clinical Sciences), Göteborg, Not set

Lanssjukhuset Ryhov - Onkologiska Kliniken, Jönköping, Not set

Skanes Universitetssjukhus - Lund - Onkologiska Klinik, Lund, Not set

Karolinska Universitetssjukhuset, Stockholm, Not set

Uppsala Universitet - Akademiska Sjukhuset (Uppsala University Hospital), Uppsala, Not set

UniversitaetsSpital Zuerich - Dermatologische Klinik, Zurich, Not set

Memorial Saglik Grubu - Memorial Ankara Hastanesi, Çankaya, Ankara

Medical Park Hastaneler Grubu - I.A.U. VM Medical Park Florya, Antalya, Campus

Medical Park Gaziantep Hastanesi, Şehitkamil, Gaziantep

Memorial Saglik Grubu - Memorial Bahcelievler Hastanesi, Bahçelievler, Istanbul

Ege Universitesi Tip Fakultesi (Ege University Faculty of Medicine), Bornova, İzmir

Izmir Ekonomi Universitesi Medikal Point Hastanesi, Karşıyaka, İzmir

Kanser Enstitusu (Hacettepe University Cancer Institute), Altındağ, Not set

T.C. Saglik Bakanligi - SBU Gulhane Egitim ve Arastirma Hastanesi, Ankara, Not set

Inonu Universitesi - Turgut Ozal Tip Merkezi, Malatya, Not set

Ondokuz Mayis Universitesi (OMU) - Tip Facultesi, Samsun, Not set

Medical Park Seyhan Hastanesi, Seyhan, Not set

T.C. Saglik Bakanligi - Ankara Etlik sehir Hastanesi, Yenimahalle, Not set

Ankara Bilkent City Hospital, Oncology Department, Çankaya, Not set

Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital (AH) - Oncology Centre, Cambridge, Not set

Beatson West of Scotland Cancer Centre, Glasgow, Not set

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, Not set

Sarah Cannon Research Institute (SCRI) - London (SCRI-UK), London, Not set

The Christie NHS Foundation Trust, Manchester, Not set

Royal Marsden Hospital - Sutton, Surrey Quays, Not set

Conditions: Advanced Melanoma

Learn More ›

Radioembolization Trial Utilizing Eye90 Microspheres™ for the Treatment of Hepatocellular Carcinoma (HCC)

NCT05953337

Recruiting

This is a prospective, multi-center, open-label study to evaluate the effectiveness and safety of Eye90 microspheres® in the treatment of subjects with unresectable Hepatocellular Carcinoma (HCC). Eye90 microspheres is a medical device containing yttrium-90 (Y-90), a radioactive material, and provides local radiation brachytherapy for the treatment of liver tumors.

Gender:

ALL

Ages:

Between 18 years and 99 years

Trial Updated:

07/23/2025

Locations: The University of Arizona Cancer Center, Tucson, Arizona +20 locations

Conditions: Hepatocellular Carcinoma, Hepatocellular Carcinoma Non-resectable, Liver Cancer

Learn More ›

Prostate Active Surveillance Study

NCT00756665

Recruiting

The Prostate Active Surveillance Study (PASS) is a research study for men who have chosen active surveillance as a management plan for their prostate cancer. Active surveillance is defined as close monitoring of prostate cancer with the offer of treatment if there are changes in test results. This study seeks to discover markers that will identify cancers that are more aggressive from those tumors that grow slowly.

Gender:

MALE

Ages:

21 years and above

Trial Updated:

07/23/2025

Locations: Veterans Affairs San Francisco Health Care System, San Francisco, California +10 locations

Conditions: Prostatic Neoplasms

Learn More ›

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

NCT05503797

Recruiting

The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with locally advanced or metastatic solid tumors, or recurrent or progressive primary central nervous system (CNS) tumors harboring BRAF fusions, or in participants with rare BRAF V600-mutated solid tumors, melanoma, thyroid, or recurrent primary CNS tumors.

Gender:

ALL

Ages:

10 years and above

Trial Updated:

07/23/2025

Locations: UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California +59 locations

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California

University of California Los Angeles Rheumatology, Westwood, California

University of Miami Hospital and Clinics, Miami, Florida

The John Hopkins Hospital, Baltimore, Maryland

Maryland Oncology Hematology- Columbia, Rockville, Maryland

Tufts Medical Center, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

St. Luke's Hospital, Duluth, Minnesota

Mosaic Life Care at Saint Joseph - Medical Center, Saint Joseph, Missouri

Nebraska Cancer Specialists - Midwest Cancer Center - Legacy, Omaha, Nebraska

Overlook Medical Center, Summit, New Jersey

Columbia University Irving Medical Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Nationwide Children's Hospital, Columbus, Ohio

Taylor Cancer Research Center, Maumee, Ohio

Toledo Clinic Cancer Center, Toledo, Ohio

Thomas Jefferson University, Philadelphia, Pennsylvania

Lifespan Cancer Institute - Rhode Island Hospital, Providence, Rhode Island

Baylor Scott & White Research Institute, Dallas, Texas

Baylor Scott & White Medical Center, Temple, Texas

University of Washington School of Medicine, Seattle, Washington

West Virginia University Health Sciences Campus, Morgantown, West Virginia

Newcastle Private Hospital, New Lambton Heights, New South Wales

Orange Health Service, Orange, New South Wales

Sydney Children's Hospital Network - Randwick, Randwick, New South Wales

The Alfred, Melbourne, Victoria

Sunny brook Health Sciences Centre- Bayview Campus, Toronto, Ontario

Centre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec

Institut Bergonie, Bordeaux Cedex, Aquitaine

Hôpital Nord de Marseille, Marseille, Bouches-du-Rhône

Hôpital Morvan, Brest, Finistère

Hôpital Universitaire Pitié Salpêtrière, Paris, Ile-de-France

Institut de Cancerologie de l'Ouest- Angers, Angers, Pays De La Loire

Gustave Roussy, Villejuif, Val-de-Marne

Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, Not set

Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg

Krankenhaus Nordwest, Frankfurt, Hessen

Charité - Universitätsmedizin Berlin, Berlin, Not set

Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST, Meldola, Forli-Cesena

Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Naples

Istituto Europeo di Oncologia, Milano, Not set

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele, Milan, Not set

Catholic University of Korea Saint Vincent's Hospital, Suwon-si, Gyeonggi-do

Seoul National University Hospital, Suwon, Gyeonggido

Dong-A University Hospital, Busan, Gyeongsangnam-do

Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do

Seoul National University Hospital, Seoul, Seoul Teugbyeoisi

Severance Hospital, Seoul, Seoul Teugbyeolsi

Haukeland Univeritetssjukehus, Bergen, Hordaland

Oslo Universitetssykehus-Radiumhospitalet, Oslo, Not set

Hospital Clinico Universitarlo de Santiago, Santiago De Compostela, A Coruña

Hospital Clinico Universitarlo de Valencia, València, Valencia

Hospital Universitari Vall d'Hebron, Barcelona, Not set

Hospital Infantil Universitario Niño Jesús, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario Virgen del Rocío, Sevilla, Not set

Skånes Universitetssjukhus, Lund, Skåne Län

Karolinska Universitetssjukhuset, Solna, Stockholms Län

The Christie NHS Foundation Trust, Manchester, England

Sarah Cannon Research Institute, London, Not set

Conditions: Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors, Melanoma BRAF V600E/K Mutated, Thyroid Cancer

Learn More ›

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

NCT06764485

Recruiting

The purpose of this study is to compare the efficacy and safety of BMS-986365 versus the investigator's choice of therapy in participants with Metastatic Castration-resistant Prostate Cancer.

Gender:

MALE

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: Local Institution - 0330, Birmingham, Alabama +247 locations

Local Institution - 0330, Birmingham, Alabama

Banner MD Anderson Cancer Center, Gilbert, Arizona

Los Angeles Cancer Network (LACN), Anaheim, California

Moores Cancer Center, La Jolla, California

Cancer and Blood Specialty Clinic, Los Alamitos, California

Local Institution - 0364, Los Angeles, California

Pacific Hematology Oncology Associates, San Francisco, California

Local Institution - 0411, San Francisco, California

Local Institution - 0238, Aurora, Colorado

Rocky Mountain Cancer Centers, LLP, Denver, Colorado

Local Institution - 0419, Lakewood, Colorado

Sibley Memorial Hospital, Washington, District of Columbia

Local Institution - 0426, Lakeland, Florida

University Cancer & Blood Center, LLC, Athens, Georgia

Local Institution - 0048, Chicago, Illinois

The University of Kansas Cancer Center - Westwood, Westwood, Kansas

Wichita Urology Group, Wichita, Kansas

Johns Hopkins Hospital, Baltimore, Maryland

Local Institution - 0344, Frederick, Maryland

Local Institution - 0054, Towson, Maryland

Local Institution - 0104, Minneapolis, Minnesota

Local Institution - 0049, Las Vegas, Nevada

Local Institution - 0429, Sewell, New Jersey

University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico

New Mexico Oncology Hematology Consultants Ltd., Albuquerque, New Mexico

Local Institution - 0197, Buffalo, New York

Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York

Laura and Isaac Perlmutter Cancer Center, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Local Institution - 0085, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Associated Medical Professionals - Urology, Syracuse, New York

Local Institution - 0056, Columbus, Ohio

Providence Portland Medical Center, Portland, Oregon

Providence St. Vincent Medical Center, Portland, Oregon

Local Institution - 0345, Philadelphia, Pennsylvania

Local Institution - 0414, Philadelphia, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Local Institution - 0349, Willow Grove, Pennsylvania

Local Institution - 0055, Charleston, South Carolina

Carolina Urologic Research Center, LLC, Myrtle Beach, South Carolina

Tennessee Oncology, Nashville, Tennessee

Local Institution - 0114, Austin, Texas

Texas Oncology - Central/South Texas, Austin, Texas

Local Institution - 0220, Houston, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

Intermountain Medical Center, Murray, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

Local Institution - 0023, Richmond, Virginia

Local Institution - 0078, Seattle, Washington

Northwest Cancer Specialists, P.C., Vancouver, Washington

Local Institution - 0112, Milwaukee, Wisconsin

Hospital Británico de Buenos Aires, Caba, Buenos Aires

Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires

Local Institution - 0128, ABB, Ciudad Autónoma De Buenos Aires

Hospital Italiano de Córdoba, Cordoba, Córdoba

Local Institution - 0130, Río Cuarto, Córdoba

Clinica Viedma S. A, Viedma, R

Asociación de Beneficencia Hospital Sirio Libanés, Buenos Aires, Not set

GenesisCare - Campbelltown, Campbelltown, New South Wales

St Vincent's Hospital, Darlinghurst, New South Wales

Macquarie University, Macquarie University, New South Wales

Port Macquarie - Mid North Coast Cancer Institute, Port Macquarie, New South Wales

Sydney Adventist Hospital, Wahroonga, New South Wales

Greenslopes Private Hospital - Gallipoli Medical Research Foundation, Greenslopes, Queensland

Tasman Oncology Research, Southport, Queensland

Royal Adelaide Hospital, Adelaide, South Australia

Lyell McEwin Hospital, Elizabeth Vale, South Australia

ICON Cancer Centre - Kurralta Park, Kurralta Park, South Australia

Icon Cancer Centre Hobart, Hobart, Tasmania

Austin Health, Heidelberg, Victoria

Cabrini Hospital - Malvern, Malvern, Victoria

Peter MacCallum Cancer Centre, Melbourne, Victoria

The Alfred Hospital, Melbourne, Victoria

St. John of God Murdoch Hospital, Murdoch, Western Australia

Universitätsklinikum Krems, Krems, Niederösterreich

Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich

Local Institution - 0367, Salzburg, Not set

Medizinische Universität Wien, Wien, Not set

Local Institution - 0039, Vitória, Espírito Santo

Local Institution - 0025, Belo Horizonte, Minas Gerais

Local Institution - 0035, Natal, Rio Grande Do Norte

Local Institution - 0026, Porto Alegre, Rio Grande Do Sul

Local Institution - 0395, Sao Paulo, São Paulo

Local Institution - 0031, Sao Paulo, São Paulo

Local Institution - 0304, Kelowna, British Columbia

BC Cancer Vancouver, Vancouver, British Columbia

Local Institution - 0151, Halifax, Nova Scotia

Local Institution - 0193, Toronto, Ontario

CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec

Local Institution - 0149, Montreal, Quebec

Local Institution - 0305, Montréal, Quebec

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Quebec City, Quebec

Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski, Quebec

Local Institution - 0236, Valdivia, Los Rios

Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago

Bradfordhill, Santiago, Región Metropolitana De Santiago

Oncocentro Apys, Viña del Mar, Valparaíso

Local Institution - 0232, Hefei, Anhui

Local Institution - 0168, Beijing, Beijing

Local Institution - 0192, Beijing, Beijing

Local Institution - 0176, Beijing, Beijing

Local Institution - 0237, Chongqing, Chongqing

Local Institution - 0249, Fuzhou, Fujian

Local Institution - 0213, Xiamen, Fujian

Local Institution - 0226, Guangzhou, Guangdong

Local Institution - 0180, Guangzhou, Guangdong

Local Institution - 0415, Huizhou, Guangdong

Local Institution - 0222, Harbin, Heilongjiang

Local Institution - 0211, Zhengzhou, Henan

Local Institution - 0279, Zhengzhou, Henan

Local Institution - 0284, Wuhan, Hubei

Local Institution - 0216, Changsha, Hunan

Local Institution - 0217, Changsha, Hunan

Local Institution - 0417, Changzhou, Jiangsu

Local Institution - 0233, Nanjing, Jiangsu

Local Institution - 0228, Nanjing, Jiangsu

Local Institution - 0229, Nanjing, Jiangsu

Local Institution - 0219, Nanchang, Jiangxi

Local Institution - 0198, Xi'an, Shaanxi

Local Institution - 0191, Jinan, Shandong

Local Institution - 0221, Yantai, Shandong

Local Institution - 0300, Shanghai, Shanghai

Local Institution - 0212, Shanghai, Shanghai

Local Institution - 0214, Shanghai, Shanghai

Local Institution - 0215, Shanghai, Shanghai

Local Institution - 0308, Shanghai, Shanghai

Local Institution - 0205, Taiyuan, Shanxi

Local Institution - 0278, Cheng Du, Sichuan

Local Institution - 0240, Chengdu, Sichuan

Local Institution - 0283, Chengdu, Sichuan

Local Institution - 0218, Urumqi, Xinjiang

Local Institution - 0181, Hangzhou, Zhejiang

Local Institution - 0196, Hangzhou, Zhejiang

Local Institution - 0280, Hangzhou, Zhejiang

Local Institution - 0281, Linhai, Zhejiang

Local Institution - 0223, Wenzhou, Zhejiang

Local Institution - 0011, Horovice, Beroun

Masarykuv onkologicky ustav, Brno, Brno-město

Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové

Fakultni nemocnice Olomouc, Olomouc, Olomoucký Kraj

Local Institution - 0009, Prague, Praha 2

Local Institution - 0418, Prague, Praha 4

Fakultni nemocnice v Motole, Praha, Praha 5

Local Institution - 0006, Praha 2, Not set

Herlev and Gentofte Hospital, Copenhagen, Hovedstaden

Rigshospitalet, Copenhagen, Hovedstaden

Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland

Aalborg Universitetshospital, Syd, Aalborg, Nordjylland

Local Institution - 0167, Nice, Alpes-Maritimes

Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg, Alsace

Oncopole Claudius Regaud, Toulouse, Haute-Garonne

Institut de Cancérologie de Lorraine Alexis Vautrin, Vandoeuvre-lès-Nancy, Lorraine

Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône

Clinique Victor Hugo Le Mans, Le Mans, Sarthe

Local Institution - 0179, Villejuif, Val-de-Marne

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne, Clermont-Ferrand, Not set

Local Institution - 0178, Paris, Not set

Local Institution - 0421, Nürtingen, Baden-Württemberg

TUM Universitätsklinikum, Technische Universität München, München, Bayern

Universitätsklinikum Schleswig-Holstein, Lübeck, Schleswig-Holstein

Universitätsklinikum Jena, Jena, Thüringen

Local Institution - 0382, Bonn, Not set

Universitaetsklinikum Essen, Essen, Not set

Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Not set

Universitaetsklinikum Heidelberg, Heidelberg, Not set

Marienhospital Herne, Herne, Not set

Universitaetsklinikum Tuebingen, Tübingen, Not set

Universitaetsklinikum Wuerzburg, Wuerzburg, Not set

Local Institution - 0271, Cork, Not set

Tallaght University Hospital, Dublin, Not set

Beaumont Hospital, Dublin, Dublin, Not set

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia

Local Institution - 0234, Orbassano, Piemonte

Local Institution - 0155, Rome, Roma

Local Institution - 0153, Padova, Veneto

Azienda USL 8 di Arezzo, Arezzo, Not set

Local Institution - 0424, Catania, Not set

Azienda Ospedaliero Universitaria Policlinico Riuniti di Foggia, Foggia, Not set

Local Institution - 0425, Milano, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Not set

Azienda Ospedaliera Santa Maria Terni, Terni, Not set

APSS- Presidio Ospedaliero S. Chiara, Trento, Not set

National Cancer Center, Goyang-si, Kyǒnggi-do

Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do

Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]

Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 0346, Wroclaw, Dolnośląskie

Państwowy Instytut Medyczny MSWiA, Warszawa, Mazowieckie

SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu, Opole, Opolskie

COPERNICUS PL, Wojewodzkie Centrum Onkologii, Gdansk, Pomorskie

Pratia Poznań, Poznań, Wielkopolskie

Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set

Local Institution - 0336, Katowice, Not set

Regional Specialised Hospital No. 4 in Bytom, Bytom, Śląskie

BRCR Global - Mayagüez, Mayaguez, Not set

Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj

Spitalul Municipal Schuller Ploiești, Ploiești, Prahova

Institutul Oncologic Cluj, Cluj, Not set

Spitalul Universitar C.F. Cluj-Napoca, Cluj, Not set

Institutul Regional de Oncologie, Iași, Not set

Local Institution - 0275, Banska Bystrica, Banskobystrický Kraj

Local Institution - 0381, Prešov, Prešovský Kraj

Local Institution - 0201, Bratislava, Not set

Local Institution - 0200, Martin, Žilinský Kraj

Hospital Universitario Reina Sofia, Cordoba, Andalucía

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Hospital Universitari Parc Tauli, Sabadell, Barcelona [Barcelona]

OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, Bizkaia

Local Institution - 0314, Santander, Cantabria

Local Institution - 0315, Barcelona, Catalunya [Cataluña]

Local Institution - 0319, Lugo, Lugo [Lugo]

Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad De

Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De

Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De

Hospital Universitario La Paz, Madrid, Madrid, Comunidad De

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De

Complejo Hospitalario de Navarra, Pamplona, Navarra

Complexo Hospitalario Universitario de Ourense, Ourense, Ourense [Orense]

Hospital Infanta Cristina, Badajoz, Not set

Hospital Universitario de Burgos, Burgos, Not set

Hospital Vithas La Salud, Granada, Not set

Hospital Clinico San Carlos, Madrid, Not set

Local Institution - 0327, Málaga, Not set

Hospital Universitario Virgen Macarena, Sevilla, Not set

Hospital Universitario Virgen Del Rocio, Sevilla, Not set

Local Institution - 0324, València, Not set

Local Institution - 0099, Lund, Skåne Län [se-12]

Karolinska Universitetssjukhuset Solna, Solna, Stockholms Län [se-01]

Akademiska sjukhuset, Uppsala, Uppsala Län [se-03]

Sahlgrenska Universitetssjukhuset, Gothenburg, Västra Götalands Län [se-14]

China Medical University Hospital, Taichung, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Local Institution - 0420, Taoyuan, Not set

Local Institution - 0340, Adana, Not set

Local Institution - 0339, Ankara, Not set

Local Institution - 0338, Ankara, Not set

Local Institution - 0341, Ankara, Not set

Local Institution - 0337, Istanbul, Not set

Local Institution - 0342, Istanbul, Not set

The Beatson West of Scotland Cancer Centre, Glasgow, Glasgow City

Mount Vernon Hospital, Northwood, Hillingdon

St Bartholomew's Hospital, London, London, City Of

Royal Marsden Hospital (Sutton), London, Sutton

The Christie NHS Foundation Trust, Manchester, Not set

Conditions: Metastatic Castration-resistant Prostate Cancer

Learn More ›

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

NCT06875310

Recruiting

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: Local Institution - 0347, Birmingham, Alabama +327 locations

Local Institution - 0347, Birmingham, Alabama

Local Institution - 0581, Fullerton, California

Local Institution - 0202, Long Beach, California

Local Institution - 0643, Newport Beach, California

Local Institution - 0666, Orange, California

Local Institution - 0623, Santa Barbara, California

Local Institution - 0442, Denver, Colorado

Local Institution - 0651, Gainesville, Florida

Local Institution - 0621, Palm Bay, Florida

Local Institution - 0377, Tamarac, Florida

Local Institution - 0647, Tampa, Florida

Local Institution - 0392, Fort Eisenhower, Georgia

Local Institution - 0031, Marietta, Georgia

Local Institution - 0665, Arlington Heights, Illinois

Local Institution - 0423, Munster, Indiana

Local Institution - 0366, Edgewood, Kentucky

Local Institution - 0566, Louisville, Kentucky

Local Institution - 0644, Shreveport, Louisiana

Local Institution - 0385, Columbia, Maryland

Local Institution - 0019, Boston, Massachusetts

Local Institution - 0437, Worcester, Massachusetts

Local Institution - 0618, White Plains, New York

Local Institution - 0624, Asheville, North Carolina

Local Institution - 0672, Salisbury, North Carolina

Local Institution - 0620, Columbus, Ohio

Local Institution - 0657, York, Pennsylvania

Local Institution - 0658, Greenville, South Carolina

Local Institution - 0652, Laredo, Texas

Local Institution - 0622, San Antonio, Texas

Local Institution - 0575, Ciudad Autónoma de Buenos Aires, Buenos Aires

IDIM - Instituto de Investigaciones Metabólicas, Ciudad de Buenos Aires, Buenos Aires

Local Institution - 0584, Pilar, Buenos Aires

Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires

Local Institution - 0571, Buenos Aires, Ciudad Autónoma De Buenos Aires

Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires

Sanatorio Plaza, Rosario, Santa Fe

Local Institution - 0126, Canberra, Australian Capital Territory

Tamworth Hospital, North Tamworth, New South Wales

Orange Hospital, Orange, New South Wales

Princess Alexandra Hospital, Brisbane, Queensland

Lyell McEwin Hospital, Elizabeth Vale, South Australia

Frankston Hospital, Frankston, Victoria

Northern Hospital, Melbourne, Victoria

Local Institution - 0160, Traralgon, Victoria

Joondalup Health Campus, Joondalup, Western Australia

Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich

Medizinische Universität Graz, Graz, Steiermark

Kepler Universitätsklinikum, Linz, Not set

Medizinische Universität Wien, Wien, Not set

Local Institution - 0673, Wien, Not set

UZ Brussel, Brussels, Bruxelles-Capitale, Région De

Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De

Local Institution - 0215, Hasselt, Limburg

Local Institution - 0216, Gent, Oost-Vlaanderen

UZ Leuven, Leuven, Vlaams-Brabant

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set

Local Institution - 0257, Salvador, Bahia

Local Institution - 0242, Vitória, Espírito Santo

Local Institution - 0244, Belo Horizonte, Minas Gerais

Local Institution - 0235, Ijui, Rio Grande Do Sul

Local Institution - 0233, Porto Alegre, Rio Grande Do Sul

Local Institution - 0238, Santa Cruz do Sul, Rio Grande Do Sul

Local Institution - 0243, Porto Velho, Rondonia

Local Institution - 0237, Blumenau, Santa Catarina

Local Institution - 0245, Itajaí, Santa Catarina

Local Institution - 0240, Barretos, São Paulo

Local Institution - 0254, Sao Paulo, São Paulo

Local Institution - 0241, São Carlos, São Paulo

Local Institution - 0239, São José do Rio Preto, São Paulo

Local Institution - 0236, Rio de Janeiro, Not set

Local Institution - 0258, São Paulo, Not set

Local Institution - 0629, Panagyurishte, Pazardzhik

Local Institution - 0628, Sofia, Sofia (stolitsa)

Complex Oncology Center - Ruse EOOD, Ruse, Not set

Local Institution - 0635, Stara Zagora, Not set

Local Institution - 0074, Halifax, Nova Scotia

Local Institution - 0559, Montreal, Quebec

Bradfordhill, Recoleta, Región Metropolitana De Santiago

FALP, Santiago, Región Metropolitana De Santiago

The First Afflilated Hospital of Bengbu Medical College, Bengbu, Anhui

Anhui Provincial Hospital, Hefei, Anhui

Beijing Cancer hospital, Beijing, Beijing

Local Institution - 0491, Beijing, Beijing

Local Institution - 0397, Beijing, Beijing

Chongqing University Cancer Hospital, Chongqing, Chongqing

Local Institution - 0362, Fuzhou Fujian, Fujian

Local Institution - 0383, Xiamen, Fujian

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong

Local Institution - 0625, Guangzhou, Guangdong

Cancer Hospital of Shantou University Medical College, Shantou, Guangdong

Local Institution - 0461, Shenzhen, Guangdong

ShenZhen People's Hospital, Shenzhen, Guangdong

Local Institution - 0464, Nanning, Guangxi

Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei

Harbin Medical University Cancer Hospital, Harbin, Heilongjiang

Nanyang City Center Hospital, Nanyang, Henan

Local Institution - 0494, Xinxiang, Henan

Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Hubei

Local Institution - 0398, Changsha, Hunan

Local Institution - 0371, Nanjing, Jiangsu

The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu

Local Institution - 0378, Yangzhou, Jiangsu

Local Institution - 0467, Nanchang, Jiangxi

The First Hospital of Jilin University, Changchun, Jilin

Local Institution - 0473, Shenyang, Liaoning

Local Institution - 0479, Shenyang, Liaoning

Local Institution - 0493, Shenyang, Liaoning

Shandong Cancer Hospital, Jinan, Shandong

LinYi Cancer Hospital, Linyi, Shandong

Local Institution - 0470, Shanghai, Shanghai

Local Institution - 0381, Shanghai, Shanghai

Local Institution - 0353, Taiyuan, Shanxi

Local Institution - 0384, Cheng Du, Sichuan

Local Institution - 0667, Chengdu, Sichuan

Tianjin Medical University General Hospital, Tianjin, Tianjin

Local Institution - 0462, Hangzhou, Zhejiang

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang

Local Institution - 0463, Hangzhou, Zhejiang

Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang

Shanghai East Hospital, Shanghai, Not set

Local Institution - 0580, Medellín, Antioquia

Local Institution - 0171, Rionegro, Antioquia

Local Institution - 0191, Puerto Colombia, Atlántico

Local Institution - 0253, Valledupar, Cesar

Local Institution - 0167, Montería, COR

Local Institution - 0671, Bogota, Cundinamarca

Local Institution - 0189, Bogotá, Distrito Capital De Bogotá

Local Institution - 0170, Floridablanca, Santander

Local Institution - 0173, Cali, Valle Del Cauca

Local Institution - 0619, Dubrovnik, Dubrovačko-neretvanska Županija

Local Institution - 0664, Rijeka, Primorsko-goranska Županija

Local Institution - 0639, Split, Splitsko-dalmatinska Županija

Local Institution - 0567, Osijek, Not set

Local Institution - 0585, Zagreb, Not set

Local Institution - 0159, Mulhouse, Alsace

Centre François Baclesse, Caen, Calvados

Centre Georges François Leclerc, Dijon, Côte-d'Or

CHRU de Brest, Brest, Finistère

Institut Régional du Cancer Montpellier, Montpellier, Hérault

Chu Grenoble Alpes, La Tronche, Isère

Local Institution - 0560, Angers, Maine-et-Loire

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Meurthe-et-Moselle

Local Institution - 0636, Marseille, Provence-Alpes-Côte-d'Azur

Local Institution - 0552, Amiens, Somme

Gustave Roussy, Villejuif, Val-de-Marne

Hôpital Ambroise Paré, Boulogne-Billancourt, Not set

Chu Gabriel Montpied, Clermont-Ferrand, Not set

Local Institution - 0604, Limoges, Not set

Local Institution - 0164, Marseille, Not set

Local Institution - 0133, Paris, Not set

Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris, Not set

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, Saint-Herblain, Not set

Klinikum Esslingen, Esslingen, Baden-Württemberg

Local Institution - 0670, Ulm, Baden-Württemberg

Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Bayern

Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, Hessen

Local Institution - 0535, Gießen, Hessen

Praxis Onkologie am Raschplatz, Hannover, Niedersachsen

Pius Hospital Oldenburg, Oldenburg, Niedersachsen

Local Institution - 0603, Herne, Nordrhein-Westfalen

Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen

Local Institution - 0522, Halle, Sachsen-Anhalt

Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Schleswig-Holstein

Local Institution - 0524, Gera, Thüringen

Universitätsklinikum Jena, Jena, Thüringen

Vivantes Klinikum Neukölln, Berlin, Not set

Local Institution - 0537, Berlin, Not set

Local Institution - 0675, Halle, Not set

Local Institution - 0528, Hemer, Not set

Local Institution - 0517, Stuttgart, Not set

Local Institution - 0525, Wuerzburg, Not set

Local Institution - 0608, Athens, Attikí

Local Institution - 0612, Athens, Attikí

Local Institution - 0609, Larissa, Thessalía

Queen Mary Hospital, Hksar, Not set

Local Institution - 0601, Gyor, Győr-Moson-Sopron

Local Institution - 0144, Gyöngyös, Heves

Local Institution - 0157, Tatabánya, Komárom-Esztergom

Local Institution - 0593, Kaposvár, Somogy

Local Institution - 0143, Farkasgyepu, Veszprém

Local Institution - 0151, Budapest, Not set

Local Institution - 0140, Budapest, Not set

Local Institution - 0222, Visakhapatnam, Andhra Pradesh

Local Institution - 0312, New Delhi, Delhi

Local Institution - 0511, New Delhi, Delhi

Local Institution - 0135, New Delhi, Delhi

Local Institution - 0136, Ahmedabad, Gujarat

Local Institution - 0230, Ahmedabad, Gujarat

Local Institution - 0155, Thiruvananthapuram, Kerala

Local Institution - 0154, Mumbai, Maharashtra

Local Institution - 0226, Bhubaneswar, Odisha

Local Institution - 0224, Madurai, Tamil Nadu

Local Institution - 0663, Hyderabad, Telangana

Local Institution - 0153, Varanasi, Uttar Pradesh

Local Institution - 0161, Howrah, West Bengal

Local Institution - 0221, Kolkata, West Bengal

Local Institution - 0661, Hyderabad, Not set

Local Institution - 0102, Cork, Not set

Mater Private Hospital - Dublin, Dublin, Not set

Local Institution - 0101, Dublin, Not set

Local Institution - 0100, Dublin, Not set

Local Institution - 0106, Dublin, Not set

Local Institution - 0597, Petah Tikva, HaMerkaz

Local Institution - 0596, Ramat Gan, HaMerkaz

Yitzhak Shamir Medical Center, Zerifin, HaMerkaz

Hadassah Medical Center, Jerusalem, Yerushalayim

Local Institution - 0613, Haifa, Ḥeifā

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna

Local Institution - 0066, Naples, Napoli

Local Institution - 0070, Orbassano, Piemonte

Local Institution - 0071, Bari, Puglia

Local Institution - 0068, Rome, Roma

Local Institution - 0069, Firenze, Toscana

Local Institution - 0588, Genova, Not set

Local Institution - 0073, Padova, Not set

Local Institution - 0156, Parma, Not set

Local Institution - 0543, Pavia, Not set

Local Institution - 0556, Varese, Not set

Local Institution - 0607, Nagoya, Aichi

Local Institution - 0305, Nagoya, Aichi

Local Institution - 0298, Sapporo, Hokkaido

Local Institution - 0304, Kanazawa, Ishikawa

Local Institution - 0302, Sagamihara, Kanagawa

Local Institution - 0369, Yokohama, Kanagawa

Local Institution - 0301, Sendai, Miyagi

Local Institution - 0306, Kashihara, Nara

Local Institution - 0368, Kurashiki, Okayama

Local Institution - 0642, Hirakata, Osaka

Local Institution - 0303, Hidaka, Saitama

Local Institution - 0300, Ina-machi, Saitama

Local Institution - 0606, Hamamatsu, Shizuoka

Local Institution - 0299, Shimotsuga, Tochigi

Local Institution - 0343, Toyoma, Toyama

Local Institution - 0542, Iwakuni, Yamaguchi

Local Institution - 0307, Akashi, Not set

Local Institution - 0346, Aomori, Not set

Local Institution - 0310, Fukuoka, Not set

Local Institution - 0367, Fukushima, Not set

Local Institution - 0308, Kumamoto, Not set

Local Institution - 0297, Osaka, Not set

Local Institution - 0309, Osaka, Not set

Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]

Gachon University Gil Medical Center, Namdong-gu, Incheon-gwangyeoksi [Incheon]

Pusan National University Yangsan Hospital, Yangsan, Kyǒngsangnam-do

Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi

Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]

Konkuk University Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Korea University Guro Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 0583, Saltillo, Coahuila

Local Institution - 0176, Mexico City, DIF

Local Institution - 0579, Pachuca, Hidalgo

Local Institution - 0178, Guadalajara, Jalisco

Local Institution - 0591, Monterrey, Nuevo León

Local Institution - 0175, Chihuahua, Not set

Local Institution - 0181, Puebla, Not set

Local Institution - 0638, Puebla, Not set

Local Institution - 0180, Veracruz, Not set

Local Institution - 0615, Maastricht, Limburg

Local Institution - 0594, Amsterdam, Noord-Holland

Local Institution - 0205, Wrocław, Dolnośląskie

Local Institution - 0080, Lublin, Lubelskie

Local Institution - 0206, Gorlice, Małopolskie

Local Institution - 0079, Kraków, Małopolskie

Med-Polonia Sp. z o. o., Poznan, Wielkopolskie

Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set

Local Institution - 0078, Katowice, Not set

Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Not set

Local Institution - 0509, Lisbon, Lisboa

Local Institution - 0510, Coimbra, Not set

Local Institution - 0553, Porto, Not set

SC Memorial Healthcare International SRL, Bucharest, București

Institutul Oncologic Bucuresti, Bucharest, București

Local Institution - 0276, Cluj-Napoca, Cluj

SC Radiotherapy Center Cluj SRL, Florești, Cluj

Ovidius Clinical Hospital OCH, Ovidiu, Constanța

Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj

Spitalul Municipal Schuller Ploiești, Ploiești, Prahova

Cabinet Medical Oncomed, Timișoara, Timiș

Institutul Oncologic Cluj, Cluj, Not set

Local Institution - 0270, Cluj, Not set

Affidea Constanța, Constanța, Not set

S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set

Institutul Regional de Oncologie, Iași, Not set

Local Institution - 0614, Jeddah, Makkah Al Mukarramah

Local Institution - 0602, Riyadh, Not set

Local Institution - 0562, Riyadh, Not set

Local Institution - 0499, A Coruña, A Coruña [La Coruña]

Local Institution - 0506, Santiago de Compostela, A Coruña [La Coruña]

Local Institution - 0501, Barcelona, Barcelona [Barcelona]

Local Institution - 0497, Hospitalet, Barcelona [Barcelona]

Local Institution - 0505, Barcelona, Catalunya [Cataluña]

Hospital Son Llàtzer, Palma, Illes Balears [Islas Baleares]

Local Institution - 0500, Madrid, Madrid, Comunidad De

Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De

Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De

Local Institution - 0669, Pontevedra, Pontevedra [Pontevedra]

Hospital Arnau de Vilanova, Valencia, València

Hospital Clinico San Carlos, Madrid, Not set

H.R.U Málaga - Hospital General, Málaga, Not set

Hospital Universitario Virgen Del Rocio, Sevilla, Not set

Local Institution - 0495, València, Not set

Kantonsspital Münsterlingen - Spital Thurgau AG, Münsterlingen, Not set

Chi Mei Hospital - Liouying Branch, Tainan City, Tainan

Tri-Service General Hospital, Taipei City, Taipei

Taipei Medical University Shuang Ho Hospital, New Taipei, Not set

National Cheng Kung University Hospital, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Local Institution - 0565, Muang, Khon Kaen

Local Institution - 0563, Bangkok, Krung Thep Maha Nakhon

Local Institution - 0564, Hatyai, Songkhla

Local Institution - 0548, Stanbul, İstanbul

Local Institution - 0199, Izmir, Karsiyaka, İzmir

Local Institution - 0197, Adana, Not set

Local Institution - 0201, Ankara, Not set

Local Institution - 0194, Ankara, Not set

Local Institution - 0198, Ankara, Not set

Local Institution - 0550, Istanbul, Not set

Local Institution - 0549, Istanbul, Not set

Local Institution - 0200, Izmir, Not set

University College London Hospital, London, London, City Of

Guy's & St Thomas' NHS Foundation Trust, London, London, City Of

Local Institution - 0092, Birmingham, Not set

Local Institution - 0090, Guildford, Not set

Local Institution - 0545, Guildford, Not set

Local Institution - 0093, Manchester, Not set

Conditions: Carcinoma, Non-Small-Cell Lung

Learn More ›

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

NCT06868277

Recruiting

The purpose of ARTEMIDE-Lung04 is to assess the efficacy and safety of rilvegostomig compared with pembrolizumab monotherapy as 1L treatment in participants with mNSCLC and whose tumors express PD-L1.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: Research Site, Bay Pines, Florida +179 locations

Research Site, Bay Pines, Florida

Research Site, Clearwater, Florida

Research Site, Saint Petersburg, Florida

Research Site, Marietta, Georgia

Research Site, Decatur, Illinois

Research Site, Des Moines, Iowa

Research Site, Leawood, Kansas

Research Site, Lexington, Kentucky

Research Site, Frederick, Maryland

Research Site, Silver Spring, Maryland

Research Site, Towson, Maryland

Research Site, Lincoln, Nebraska

Research Site, Paramus, New Jersey

Research Site, Westbury, New York

Research Site, Canton, Ohio

Research Site, Philadelphia, Pennsylvania

Research Site, Aberdeen, Washington

Research Site, Cordoba, Not set

Research Site, Rosario, Not set

Research Site, Hobart, Not set

Research Site, Woolloongabba, Not set

Research Site, Edegem, Not set

Research Site, Liège, Not set

Research Site, Mechelen, Not set

Research Site, Roeselaere, Not set

Research Site, Blumenau, Not set

Research Site, Fortaleza, Not set

Research Site, Ijui, Not set

Research Site, Itajai, Not set

Research Site, Londrina, Not set

Research Site, Passo Fundo, Not set

Research Site, Porto Alegre, Not set

Research Site, Porto Velho, Not set

Research Site, São Paulo, Not set

Research Site, Burgas, Not set

Research Site, Panagyurishte, Not set

Research Site, Sofia, Not set

Research Site, Kelowna, British Columbia

Research Site, Cambridge, Ontario

Research Site, Toronto, Ontario

Research Site, Baoding, Not set

Research Site, Beijing, Not set

Research Site, Changchun, Not set

Research Site, Changsha, Not set

Research Site, Chongqing, Not set

Research Site, Fuzhou, Not set

Research Site, Guangzhou, Not set

Research Site, Jiamusi, Not set

Research Site, Jinan, Not set

Research Site, Lanzhou, Not set

Research Site, Linyi, Not set

Research Site, Nanchang, Not set

Research Site, Nanjing, Not set

Research Site, Ningbo, Not set

Research Site, Shanghai, Not set

Research Site, Shenyang, Not set

Research Site, Suzhou, Not set

Research Site, Wuhan, Not set

Research Site, Xuzhou, Not set

Research Site, Yantai, Not set

Research Site, Valledupar, Not set

Research Site, Angers, Not set

Research Site, Avignon, Not set

Research Site, Caen, Not set

Research Site, Dijon, Not set

Research Site, La Tronche, Not set

Research Site, Limoges, Not set

Research Site, Nantes CEDEX 1, Not set

Research Site, Paris, Not set

Research Site, Pau Cedex, Not set

Research Site, Toulouse, Not set

Research Site, Tbilisi, Not set

Research Site, Amberg, Not set

Research Site, Bad Saarow, Not set

Research Site, Berlin, Not set

Research Site, Bonn, Not set

Research Site, Essen, Not set

Research Site, Frankfurt am Main, Not set

Research Site, Heilbronn, Not set

Research Site, Immenhausen, Not set

Research Site, Koblenz, Not set

Research Site, Leipzig, Not set

Research Site, München, Not set

Research Site, Oldenburg, Not set

Research Site, Rotenburg, Not set

Research Site, Schweinfurt, Not set

Research Site, Velbert, Not set

Research Site, Würselen, Not set

Research Site, Würzburg, Not set

Research Site, Athens, Not set

Research Site, Peiraias, Not set

Research Site, Thessaloniki, Not set

Research Site, Afula, Not set

Research Site, Beer-Sheva, Not set

Research Site, Hadera, Not set

Research Site, Haifa, Not set

Research Site, Jerusalem, Not set

Research Site, Ramat Gan, Not set

Research Site, Tel Aviv, Not set

Research Site, Tel-Aviv, Not set

Research Site, Candiolo, Not set

Research Site, Lucca, Not set

Research Site, Napoli, Not set

Research Site, Peschiera Del Garda, Not set

Research Site, Pisa, Not set

Research Site, Udine, Not set

Research Site, Verona, Not set

Research Site, Akashi, Not set

Research Site, Bunkyo-ku, Not set

Research Site, Fukuoka-shi, Not set

Research Site, Fukuoka-Shi, Not set

Research Site, Hamamatsu-shi, Not set

Research Site, Iwakuni-shi, Not set

Research Site, Izumi-shi, Not set

Research Site, Kashihara-shi, Not set

Research Site, Kobe, Not set

Research Site, Koto-ku, Not set

Research Site, Kurume-shi, Not set

Research Site, Kyoto-shi, Not set

Research Site, Matsuyama-shi, Not set

Research Site, Nankoku-shi, Not set

Research Site, Niigata-shi, Not set

Research Site, Osaka-shi, Not set

Research Site, Osakasayama, Not set

Research Site, Sakai-shi, Not set

Research Site, Sendai-shi, Not set

Research Site, Shinagawa-ku, Not set

Research Site, Toyoake-shi, Not set

Research Site, Toyonaka-shi, Not set

Research Site, Jinju-si, Not set

Research Site, Seoul, Not set

Research Site, Kuala Lumpur, Not set

Research Site, Perai, Not set

Research Site, Selangor, Not set

Research Site, Alcabideche, Not set

Research Site, Lisboa, Not set

Research Site, Lisbon, Not set

Research Site, Porto, Not set

Research Site, Bucuresti, Not set

Research Site, Craiova, Not set

Research Site, Iasi, Not set

Research Site, Pitesti, Not set

Research Site, Badalona, Not set

Research Site, Castellón, Not set

Research Site, Granada, Not set

Research Site, Madrid, Not set

Research Site, Málaga, Not set

Research Site, Oviedo, Not set

Research Site, Valencia, Not set

Research Site, Bakirkoy, Not set

Research Site, Izmit, Not set

Research Site, Yüreğir, Not set

Research Site, Çankaya, Not set

Research Site, Blackpool, Not set

Research Site, Hull, Not set

Research Site, Stevenage, Not set

Conditions: Carcinoma, Non-Small Cell Lung

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Scaling Up Point-of-Care Hepatitis C Testing and Treatment in Canada

NCT07095192

Recruiting

The SCALE-POCT study is a national initiative designed to provide robust evidence for scaling up point-of-care hepatitis C testing for key populations. The study seeks to map current hepatitis C clinical processes, identify barriers and facilitators to implementation, and co-design practical tools and strategies in partnership with stakeholders. A major obstacle to hepatitis C elimination and increasing treatment uptake is the current multi-step diagnostic process, which leads to loss to follow... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: Anonyme L'Unite D'Intervention, Montreal, Quebec +11 locations

Conditions: HCV, HEPATITIS C VIRUS CHRONIC INFECTION

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A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants

NCT06115967

Recruiting

This study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses of AZD6912 administered subcutaneously (SC) in healthy participants.

Gender:

ALL

Ages:

Between 18 years and 50 years

Trial Updated:

07/23/2025

Locations: Research Site, Montréal, Quebec +1 locations

Conditions: Rheumatoid Arthritis

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Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive Impairment

NCT06041152

Recruiting

The goal of this clinical trial is to investigate the effects of psilocybin on synaptic vesicular density (SVD) as measured by the positron emission tomography (PET) radiotracer, 18F-SynVesT-1, in participants with amnestic Mild Cognitive Impairment (aMCI) and healthy participants. The investigators hypothesize that SVD levels in the brain will be higher following the ingestion of psilocybin in comparison to placebo, and that increases in SVD will be associated with improvements in cognition. 6... Read More

Gender:

ALL

Ages:

Between 60 years and 75 years

Trial Updated:

07/23/2025

Locations: Centre for Addiction and Mental Health, Toronto, Ontario

Conditions: Amnestic Mild Cognitive Impairment

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Comprehensive Aneurysm Management Trial

NCT04155606

Recruiting

The uncertainty regarding the management of Unruptured Intracranial Aneurysms (UIAs) has not progressed in the last 30 years. The fundamental ethical basis for this study is that physicians should only offer a risky preventive treatment when it has been shown to be beneficial. Before that, such treatment should be offered as an RCT. The CAM trial offers a comprehensive framework, so that all patients confronted with the clinical dilemma can be offered participation. The principal questions to be addressed are : 1. do patients with UIAs, considered for curative treatments, have a better long-term clinical outcome with active treatment or conservative management? 2. when patients are considered ineligible for conservative management, and surgical and endovascular management are both judged reasonable, do patients with UIAs have a better long-term clinical outcome with surgical or endovascular management? The primary hypothesis for patients allocated to at least 2 options, one of which is conservative management is: the 10 year combined neurological morbidity and mortality (mRS\>2) will be reduced from 24% to 16% (beta 80%; alpha 0.048; sample size 961 patients (836 plus 15% losses to FU and cross-overs) with active treatment. This study is designed as a pragmatic, comprehensive way to address the unruptured aneurysm clinical dilemma, combining large simple RCTs whenever patients are judged eligible for more than one management option, or otherwise a registry of each option. All patients with one or more UIAs will be eligible for participation in either a registry or one of the trials. Patients will be followed for 10 years according to a standard of car follow-up schedule. The primary outcome is survival without neurological dependency (mRS\<3) at 10 years. The secondary outcomes are: 1. the incidence of SAH during follow-up and related morbidity and mortality; 2. the morbidity and mortality related to endovascular or surgical treatment of the UIA at one year; 3. overall mortality at 1, 5 and 10 years; 4. overall morbidity (mRS\>2) at 1, 5 and 10 years; 5. length of hospitalization; 6. discharge to location other than home Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: University of Alberta Hospital, Edmonton, Alberta +5 locations

Conditions: Saccular Aneurysm, Intracranial Aneurysm, Unruptured Cerebral Aneurysm

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A Study Comparing Venetoclax and Azacitidine Plus Cusatuzumab to Venetoclax and Azacitidine in Newly Diagnosed AML Ineligible for Intensive Therapy

NCT06384261

Recruiting

The goal of this clinical trial is to learn if participants treated with the experimental drug cusatuzumab added to venetoclax and azacitidine works to treat acute myeloid leukemia (AML) compared to venetoclax and azacitidine. Venetoclax and azacitidine are drugs commonly used to treat AML in patients that are unable to receive chemotherapy to treat AML. The main question the clinical trial aims to answer is does cusatuzumab added to venetoclax and azacitidine prolong the length of time particip... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/23/2025

Locations: Banner MD Anderson, Gilbert, Arizona +30 locations

Banner MD Anderson, Gilbert, Arizona

City of Hope, Duarte, California

University of California Los Angeles, Los Angeles, California

University of Colorado Health - Anschutz Cancer Pavilion - Anschutz Medical Campus, Aurora, Colorado

Yale School of Medicine, New Haven, Connecticut

AdventHealth Medical Group Blood & Marrow Transplant at Orlando, Orlando, Florida

The University of Iowa Hospitals & Clinics, Iowa City, Iowa

University of Kentucky Chandler Medical Center, Lexington, Kentucky

Norton Healthcare, Inc., Louisville, Kentucky

Hackensack University Medical Center, Hackensack, New Jersey

Hofstra/Northwell Health, Lake Success, New York

Cornell University, New York, New York

University of Rochester Medical Center, Rochester, New York

Wake Forest North Carolina, Winston-Salem, North Carolina

Medical University of South Carolina, Charleston, South Carolina

Fred Hutch Seattle Cancer Care Alliance, Seattle, Washington

Medical College of Wisonsin, Milwaukee, Wisconsin

Tom Baker Cancer Center-Alberta Health Services - University of Calgary, Calgary, Alberta

Stollery Children's Hospital-Walter C Mackenzie Health Sciences Centre - University of Alberta, Edmonton, Alberta

Vancouver General Hospital, Gordon and Leslie Diamond Health Care Centre, Vancouver, British Columbia

University of Western Ontario, London, Ontario

The Ottawa Hospital - General Campus, Ottawa, Ontario

Princess Margaret Cancer Centre, Toronto, Ontario

Saskatchewan Cancer Agency - Saskatoon Cancer Centre, Saskatoon, Saskatchewan

Marien Hospital Duesseldorf, Dusseldorf, Not set

Universitaetsklinik Frankfurt, Frankfurt, Not set

Medizinische Hochschule Hanover, Hannover Medical School, Hannover, Not set

Universitaetsklinik um Schleswig-Holstein, UKSH-Campus Kiel, Kiel, Not set

Inselspital Bern, Bern, Not set

HFR Fribourg - Hopital Cantonal, Fribourg, Not set

Kantonsspital St. Gallen, Saint Gallen, Not set

Conditions: Leukemia, Myeloid, Acute

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