1% Lidocaine Paracervical Block for Endometrial Biopsy
NCT06546254
Recruiting
The objective of this study is to to determine whether 1% lidocaine paracervical block reduces pain during endometrial biopsy in comparison to no intervention. The proposed study is a double-blind randomized controlled trial (RCT). Each participant will be randomly assigned to one of two arms: 1. intervention (paracervical block - 10 mL 1% lidocaine with epinephrine) 2. control (gently tapping the cervicovaginal junction with a capped needle) The primary outcome will be a global pain score,... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: OPG, Toronto, Ontario
Conditions: Endometrial Biopsy
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ATI-045 Versus Placebo in Patients With Moderate-to-Severe Atopic Dermatitis
NCT07011706
Recruiting
This study evaluates ATI-045 versus placebo in patients with Moderate-to-Severe Atopic Dermatitis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/28/2025
Locations: Aclaris Study Site, Bryant, Arkansas +22 locations
Conditions: Atopic Dermatitis, Atopic, Dermatitis, AD, Eczema
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Cannabidiol After Multi-Trauma for Pain and Opioid Therapy
NCT06448923
Recruiting
The aim of this project is to investigate the therapeutic potential and safety of acute Cannabidiol (CBD) treatment on longitudinal pain symptoms, and to assess potential interactions with pain mediators including opioids and sex on CBD treatment response. To this end, this research protocol proposes a comprehensive translational approach including a placebo-controlled randomized clinical trial comparing two daily doses of CBD treatment administered for one month on pain relief. This study will... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/28/2025
Locations: Hôpital Sacré-Coeur de Montréal, Montréal, Quebec
Conditions: Fracture
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Presacral Nerve Block Versus Sham Block on Post-operative Pain for Total Laparoscopic Hysterectomy
NCT05953766
Recruiting
The study is a single-center parallel group randomized controlled trial comparing the administration of a presacral nerve block using 20mL of local ropivacaine 5.0mg/ml versus 20mL of normal saline (sham block) on post-operative pain following total laparoscopic hysterectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Mount Sinai Hospital, Toronto, Ontario
Conditions: Post-operative Pain
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Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
NCT06331312
Recruiting
The purpose of this extension study is to assess the safety and tolerability of secukinumab when administered long-term in patients with polymyalgia rheumatica.
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
07/28/2025
Locations: Arizona Arthritis and Rheumatology Associates PLLC, Avondale, Arizona +108 locations
Conditions: Polymyalgia Rheumatica
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A Study to Evaluate the Effect of Budesonide, Glycopyrronium, Formoterol Fumarate (BGF) Metered Dose Inhaler (MDI), Budesonide and Formoterol Fumarate (BFF) MDI and Placebo MDI on Exercise Parameters in Participants With Chronic Obstructive Pulmonary Disease (COPD).
NCT06067828
Recruiting
This study will investigate the effect of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) metered dose inhaler (MDI) compared with Placebo MDI, and Budesonide and Formoterol Fumarate (BFF) MDI on isotime inspiratory capacity (IC) and exercise endurance time.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
07/28/2025
Locations: Research Site, Los Angeles, California +36 locations
Conditions: Chronic Obstructive Pulmonary Disease
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Higher vs. Lower Dose Heparin for PCI
NCT04049591
Recruiting
HD PCI is a multicenter, randomized, registry-based, cluster crossover design trial of higher dose versus lower dose heparin in patients undergoing elective percutaneous coronary intervention (PCI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Hamilton Health Sciences, General Hospital, Hamilton, Ontario
Conditions: Cardiovascular Diseases, Percutaneous Coronary Intervention
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Anticoagulation After GI Bleeding Pilot Study and Registry
NCT05290857
Recruiting
PANTHER-GI Pilot Study will assess the feasibility of a full-scale multicentre cohort management study evaluating the safety of a standardized strategy for resuming direct oral anticoagulants (DOACs) after major DOAC-related gastrointestinal (GI) bleeding among patients at moderate to high risk of re-bleeding and thrombosis. A parallel registry will assess whether eligible patients who are not enrolled in the PANTHER-GI Pilot Study are systematically different than enrolled patients and to explo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Alberta Health Services - Peter Lougheed Center Endoscopy Unit, Calgary, Alberta +1 locations
Conditions: GastroIntestinal Bleeding, Anticoagulant-induced Bleeding
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Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial
NCT06884540
Recruiting
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. Few preventive interventions exist, but intravenous dexmedetomidine and lidocaine administered during general anesthesia represent simple strategies that may significantly impact recovery and other patient-centred outcomes after surgery. The goal of this pilot trial is to determine the feasibility of conducting a phase 3 pragmatic adaptive multicentre trial... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus), Québec, Quebec
Conditions: Anesthesia, Anesthesia Complication, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity, Feasibility Studies, Patient-centredness
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Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
NCT01526681
Recruiting
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting. Optional addendums 1 and 2 included in the protocol are intended to establish comparative groups and focused subgroups within the registry.
Gender:
ALL
Ages:
All
Trial Updated:
07/25/2025
Locations: RANGER & MATCH: Arizona Center for Hand Surgery, Phoenix, Arizona +48 locations
Conditions: Peripheral Nerve Injuries
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Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy
NCT06908694
Recruiting
GAIN PC CONTROL is a study investigating Glucagon-Like Peptide-1 Receptor Agonists in men with prostate cancer who are being treated with androgen deprivation therapy.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Juravinski Cancer Centre, Hamilton, Ontario
Conditions: Prostate Cancer
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A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)
NCT06963710
Recruiting
This is a Phase 2 study to evaluate efficacy and safety of 48 weeks of oral once daily monotherapy with ALG-000184 versus tenofovir disproxil fumarate (TDF) for chronic HBV infection.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/25/2025
Locations: Aligos Investigational Site, Chandler, Arizona +6 locations
Conditions: Chronic Hepatitis B Infection
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