A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFH
NCT07000136
Recruiting
This is a study to evaluate the efficacy and safety of AZD0780 in adults with HeFH and elevated LDL-C, either with clinical ASCVD and LDL-C levels of 55 mg/dL or higher or without clinical ASCVD and LDL-C levels of 70 mg/dL or higher. AZD0780 is a small molecule that reduces the amount of LDL-C in the blood. Placebo will be used for comparison, and neither the participants nor the Investigators will know who is receiving the AZD0780 medication and who is receiving the placebo until the end of st... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Research Site, Chula Vista, California +183 locations
Conditions: Heterozygous Familial Hypercholesterolaemia
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Evaluation of a Simple-Prep Controlled Embolic
NCT06453642
Recruiting
The objective of this study is to evaluate the safety and effectiveness of the GPX® Embolic Device when used as indicated for embolization requiring distal vessel penetration in 114 subjects in up to 25 investigational sites in the USA, New Zealand, and Canada.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: University of California San Diego Altman Clinical and Translation Research Institute, La Jolla, California +17 locations
Conditions: Vascular Tumor, Renal Angiomyolipoma, Renal Cell Carcinoma, Bone Tumor, Embolization, Portal Vein Embolization
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A Study of LY4100511 (DC-853) in Adult Participants With Moderate-to-Severe Plaque Psoriasis
NCT06602219
Recruiting
The main purpose of this study is to assess the safety and efficacy of LY4100511 in adult participants with moderate-to-severe plaque psoriasis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/22/2025
Locations: Cahaba Dermatology Skin Health Center, Birmingham, Alabama +57 locations
Conditions: Plaque Psoriasis
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SASS 2 : Self Assembled Skin Substitute for the Autologous Treatment of Severe Burn Wounds in Acute Stage of Burn Trauma
NCT02350205
Recruiting
This clinical trial is designed to assess the safety, effectiveness and benefits of Self Assembled Skin Substitute SASS grafts as a permanent skin replacement for the treatment of full-thickness burn wounds that require permanent coverage where the availability of donor sites is limited.
Gender:
ALL
Ages:
All
Trial Updated:
07/22/2025
Locations: Foothill Medcial Centre, Calgary, Alberta +6 locations
Conditions: Burns
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An Ophthalmic Safety Study in Patients With Breast Cancer
NCT06767462
Recruiting
To assess ophthalmic health in parallel cohorts of patients with breast cancer
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
07/22/2025
Locations: Research Site, La Jolla, California +74 locations
Conditions: Ophthalmic Safety in Patients With Breast Cancer
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Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease
NCT05099770
Recruiting
The purpose of this study is to assess the safety and efficacy (including durability) of up to 2 REACT injections given 3 months (+30 days) apart and delivered percutaneously into biopsied and non-biopsied contralateral kidneys in participants with T2DM and CKD.
Gender:
ALL
Ages:
Between 30 years and 80 years
Trial Updated:
07/22/2025
Locations: University of Arizona, Tucson, Arizona +77 locations
Conditions: Type 2 Diabetes Mellitus, Chronic Kidney Diseases
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Ambulatory Oxygen Therapy for Individuals With Mild-to-moderate Interstitial Lung Disease
NCT06053164
Recruiting
The investigators plan to conduct a study to find out if giving portable oxygen therapy (during physical activity) to patients with interstitial lung disease will improve quality of life, exercise tolerance, shortness of breath, and blood vessel function. Oxygen will be provided for a period of 8 weeks. Additionally, the investigators plan to investigate if it is helpful to deliver individualized support when providing oxygen therapy, through check-in phone calls with a respiratory therapist and... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
07/21/2025
Locations: Clinical Physiology Laboratory, Edmonton, Alberta
Conditions: Fibrotic Interstitial Lung Disease
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[Ac-225]-PSMA-62 Trial in Oligometastatic Hormone Sensitive and Metastatic Castration Resistant Prostate Cancer
NCT06229366
Recruiting
ACCEL is a multicenter, open label phase Ia/Ib/II study of \[Ac-225\]-PSMA-62 in participants with prostate-specific membrane antigen (PSMA)-positive prostate cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: BC Cancer Vancouver, Vancouver, British Columbia +6 locations
Conditions: Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, Oligometastatic Prostate Carcinoma, Hormone Sensitive Prostate Cancer
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Inhaled Treprostinil for Dyspnea and Exercise Intolerance in Mild COPD
NCT06969573
Recruiting
The goal of this clinical trial is to evaluate the impact of inhaled Treprostinil on breathlessness and low exercise capacity in patients living with mild chronic obstructive pulmonary disease. Participants will be asked to: * Perform lung function and exercise tests * Have ultrasound of their heart * Have CT images of their lungs * Visit the lab on 5 different occasions (plus one visit to the CT imaging clinic) The researchers will compare the effectiveness and feasibility of inhaled Treprost... Read More
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
07/21/2025
Locations: Clinical Physiology Laboratory, Edmonton, Alberta
Conditions: COPD (Chronic Obstructive Pulmonary Disease)
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ELIOS - Investigational Biomarkers to Track Disease Modification in Active RRMS
NCT06733922
Recruiting
The exploratory ELIOS study aims to assess the value of novel investigational Eye Movement Biomarkers (EMBs) in tracking disease-related changes among a real-world cohort of Canadian patients with active RRMS, within the context of disease-modifying treatment (i.e., ofatumumab). To that end, the study will use the patented investigational, Eye Tracking Neurological Assessment (ETNA-ProgMS) SaMD (v1.0.11 or later), which has not yet received Health Canada approval, to reliably and accurately trac... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/21/2025
Locations: Novartis Investigative Site, Halifax, Nova Scotia +4 locations
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS)
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Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
NCT04301843
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Gender:
ALL
Ages:
31 years and below
Trial Updated:
07/21/2025
Locations: University of Alabama, Children's Alabama, Birmingham, Alabama +28 locations
Conditions: Neuroblastoma
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Cardiovascular Consequences of Inhaled Short-acting Beta-agonist Use
NCT06027606
Recruiting
The goal of this clinical trial is to test the impact inhalers have on blood vessels in young healthy individuals. The main question it aims to answer is if long term use of asthma inhalers have any effect on the blood vessels and heart. Participants will be asked to: * Perform lung function and exercise tests * Have ultrasound images taken of the artery in their arm * Use an inhaler for 4 weeks * Visit the lab for testing on 4-6 different occasions Researchers will compare two different inhal... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/21/2025
Locations: Clinical Physiology Laboratory, Edmonton, Alberta
Conditions: Healthy
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