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All Clinical Trials in Canada
A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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RCT of Mind-body in Long COVID and Myalgic Encephalomyelitis
Recruiting
We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). Our team recognizes that ME/CFS and Long COVID are serious, debilitating, biomedical conditions.
ME/CFS can affect many different parts of the body, such as the nervous system, immune system, and metabolism. It is hypothesized that central sensitization (i.e., when nerves get too excited) may influence these complex conditions and may m... Read More
We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). Our team recognizes that ME/CFS and Long COVID are serious, debilitating, biomedical conditions.
ME/CFS can affect many different parts of the body, such as the nervous system, immune system, and metabolism. It is hypothesized that central sensitization (i.e., when nerves get too excited) may influence these complex conditions and may make symptoms worse.
This study explores a mind-body program called the Dynamic Neural Retraining System™, or DNRS™.
Mind-body interventions (MBIs) focus on how the brain, mind, body, and behaviour interact to improve health and well-being. These techniques help people become more aware of themselves, take better care of their health, and boost mood, quality of life, and coping skills. MBIs use the brain's ability to change (neuroplasticity) by reinforcing certain thoughts, feelings, or behaviours that support changes in biology and function. MBIs may influence physical health by affecting how the brain and body communicate through chemicals such as hormones and neurotransmitters. Objective fMRI evidence shows that practising MBIs can change brain structure and function. This makes MBIs a potential good fit for people with chronic illnesses like ME/CFS and LC, which involve complex interactions between the brain, immune system, and hormones.
There is no rigorous peer-reviewed evidence that DNRS is effective. Our study will address this question using subjective and objective measurements in a multiple-methods wait-list randomized controlled trial.
The objectives of this study are to: 1) examine the effectiveness of the DNRS program for individuals diagnosed with ME/CFS with and without Long COVID, compared to a treatment-as-usual wait-list control group on a range of patient-reported outcomes including health-related quality of life, fatigue, pain, anxiety and depression and objective measures including daily steps, heart rate variability, and sleep; 2) quantify metabolic changes through untargeted serum metabolomics profiling, 3) determine if metabolomics screening can predict treatment responsiveness to DNRS; and 4) identify the microbial signatures of large bowel microbiota in Long COVID patients pre and post MBI.
A descriptive qualitative study will also be conducted in a sample of participants to learn more about their experiences during the trial. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Peter Lougheed Hospital, Calgary, Alberta +2 locations
Peter Lougheed Hospital, Calgary, Alberta
University of Alberta Hospital/Kaye Edmonton Clinic, Edmonton, Alberta
Women's College Hospital, Toronto, Ontario
Conditions: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Recruiting
The purpose of this study is to assess the safety and tolerability and to confirm the dose of nemtabrutinib in combination with venetoclax in participants with R/R CLL/SLL. The primary study hypotheses are that the combination of nemtabrutinib plus venetoclax is superior to VR with respect to progression-free survival (PFS) per 2018 International Workshop on Chronic Lymphocytic Leukemia (iwCLL) criteria as assessed by blinded independent central review (BICR).
The purpose of this study is to assess the safety and tolerability and to confirm the dose of nemtabrutinib in combination with venetoclax in participants with R/R CLL/SLL. The primary study hypotheses are that the combination of nemtabrutinib plus venetoclax is superior to VR with respect to progression-free survival (PFS) per 2018 International Workshop on Chronic Lymphocytic Leukemia (iwCLL) criteria as assessed by blinded independent central review (BICR). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Highlands Oncology Group ( Site 5405), Springdale, Arkansas +51 locations
Highlands Oncology Group ( Site 5405), Springdale, Arkansas
MemorialCare Health System - Long Beach Medical Center ( Site 5421), Long Beach, California
Memorial Hospital West ( Site 5410), Pembroke Pines, Florida
Oregon Health and Science University ( Site 5425), Portland, Oregon
Medical Oncology Associates, PS ( Site 5406), Spokane, Washington
University of Wisconsin Hospital and Clinics-Carbone Cancer Center ( Site 5423), Madison, Wisconsin
Instituto Alexander Fleming ( Site 1005), Ciudad Autónoma de Buenos Aires, Buenos Aires
Instituto de Investigaciones Clínicas Mar del Plata ( Site 1007), Mar del Plata, Buenos Aires
Sanatorio Parque ( Site 1003), Rosario, Santa Fe
Centro Medico Fleischer ( Site 1006), Buenos Aires, Not set
Hospital Aleman-oncohematologic diseases ( Site 1001), Buenos Aires, Not set
Royal Adelaide Hospital ( Site 1104), Adelaide, South Australia
Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research ( Site 1103), Melbourne, Victoria
UZ Leuven-Hematology ( Site 1200), Leuven, Vlaams-Brabant
ZAS Cadix ( Site 1203), Antwerpen, Not set
ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO-Pesquisa Clinica ( Site 1308), Sao Paulo, Not set
The Moncton Hospital ( Site 1414), Moncton, New Brunswick
Biocenter ( Site 1507), Concepcion., Biobio
IC La Serena Research ( Site 1506), La Serena., Coquimbo
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1509), Santiago., Region M. De Santiago
FALP-UIDO ( Site 1500), Santiago, Region M. De Santiago
Clínica Inmunocel ( Site 1511), Santiago, Region M. De Santiago
Fundación Valle del Lili ( Site 1703), Cali, Valle Del Cauca
Hopital Claude Huriez - CHU de Lille ( Site 2107), Lille, Nord
Centre Hospitalier Universitaire Estaing ( Site 2105), Clermont-Ferrand, Puy-de-Dome
CHD Vendee ( Site 2100), La Roche-sur-Yon, Vendee
Klinikum Mutterhaus der Borromäerinnen-Innere Medizin I ( Site 2203), Trier, Rheinland-Pfalz
Universitätsklinikum Leipzig-Medical Department I - Hematology and Celltherapy ( Site 2201), Leipzig, Sachsen
Rambam Health Care Campus ( Site 2801), Haifa, Not set
Hadassah Medical Center-Hemato-Oncology ( Site 2812), Jerusalem, Not set
Sheba Medical Center-Hemato Oncology ( Site 2809), Ramat Gan, Not set
Sourasky Medical Center ( Site 2811), Tel Aviv, Not set
Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 2906), Alessandria, Ancona
Ospedale San Raffaele-Programma di Ricerca Strategica sulla LLC ( Site 2902), Milano, Not set
Arcispedale Santa Maria Nuova-Hematology ( Site 2900), Reggio Emilia, Not set
Centro de Infusion Superare ( Site 3314), Ciudad de México, Distrito Federal
Health Pharma Professional Research S.A. de C.V: ( Site 3301), Ciudad de México, Distrito Federal
Centro de Investigacion Clinica Chapultepec ( Site 3309), Morelia, Michoacan
Auxilio Mutuo Cancer Center ( Site 3900), San Juan, Not set
Netcare Pretoria East Hospital-Albert Alberts Stem Cell Transplant Centre ( Site 4401), Moreletta Park, Gauteng
Groote Schuur Hospital ( Site 4400), Cape Town, Western Cape
Haemalife ( Site 4407), Kuilsriver, Western Cape
Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 4601), L'Hospitalet Del Llobregat, Barcelona
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 4602), Pozuelo de Alarcon, Madrid
HOSPITAL CLINICO DE VALENCIA-HEMATOLOGY ( Site 4603), Valencia, Valenciana, Comunitat
Namik Kemal University Medical Faculty-Hematology ( Site 4912), Tekirdag, Tekirdas
Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 4913), Ankara, Not set
Mega Medipol-Hematology ( Site 4904), İstanbul, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 4906), Istanbul, Not set
Ege Universitesi Hastanesi ( Site 4902), İzmir, Not set
City Hospital, Nottingham University Hospitals-Hematology ( Site 5002), Nottingham, England
University College London Hospital-Cancer Clinical Trials Unit ( Site 5001), London-Camden, London, City Of
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Chronic Lymphocytic, Small-Cell Lymphoma, Lymphoma, Small Lymphocytic, CLL, SLL
Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial
Recruiting
This phase III trial uses the Decipher risk score to guide therapy selection. Decipher score is based on the activity of 22 genes in prostate tumor and may predict how likely it is for recurrent prostate cancer to spread (metastasize) to other parts of the body. Decipher score in this study is used for patient selection and the two variations of treatment to be studied: intensification for higher Decipher score or de-intensification for low Decipher score. Patients with higher Decipher risk scor... Read More
This phase III trial uses the Decipher risk score to guide therapy selection. Decipher score is based on the activity of 22 genes in prostate tumor and may predict how likely it is for recurrent prostate cancer to spread (metastasize) to other parts of the body. Decipher score in this study is used for patient selection and the two variations of treatment to be studied: intensification for higher Decipher score or de-intensification for low Decipher score. Patients with higher Decipher risk score will be assigned to the part of the study that compares the use of 6 months of the usual treatment (hormone therapy and radiation treatment) to the use of darolutamide plus the usual treatment (intensification). The purpose of this section of the study is to determine whether the additional drug can reduce the chance of cancer coming back and spreading in patients with higher Decipher score. The addition of darolutamide to the usual treatment may better control the cancer and prevent it from spreading. Alternatively, patients with low Decipher risk score will be assigned to the part of the study that compares the use of radiation treatment alone (de-intensification) to the usual approach (6 months of hormone therapy plus radiation). The purpose of this part of the study is to determine if radiation treatment alone is as effective compared to the usual treatment without affecting the chance of tumor coming back in patients with low Decipher score prostate cancer. Radiation therapy uses high energy to kill tumor cells and reduce the tumor size. Hormone therapy drugs such as darolutamide suppress or block the production or action of male hormones that play role in prostate cancer development. Effect of radiation treatment alone in patients with low Decipher score prostate cancer could be the same as the usual approach in stabilizing prostate cancer and preventing it from spreading, while avoiding the side effects associated with hormonal therapy. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +562 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Banner MD Anderson Cancer Center, Gilbert, Arizona
Arizona Center for Cancer Care - Gilbert, Gilbert, Arizona
Arizona Center for Cancer Care-Peoria, Peoria, Arizona
Arizona Center for Cancer Care - Phoenix, Phoenix, Arizona
Arizona Center for Cancer Care - Scottsdale, Scottsdale, Arizona
Arizona Center for Cancer Care-Surprise, Surprise, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield, California
Tower Cancer Research Foundation, Beverly Hills, California
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California
City of Hope Corona, Corona, California
City of Hope Comprehensive Cancer Center, Duarte, California
Kaiser Permanente Dublin, Dublin, California
UC San Diego Health System - Encinitas, Encinitas, California
Kaiser Permanente-Fremont, Fremont, California
Washington Hospital, Fremont, California
Kaiser Permanente-Fresno, Fresno, California
Marin General Hospital, Greenbrae, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
UC San Diego Moores Cancer Center, La Jolla, California
City of Hope Antelope Valley, Lancaster, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Fremont - Rideout Cancer Center, Marysville, California
Memorial Medical Center, Modesto, California
Kaiser Permanente-Modesto, Modesto, California
Providence Queen of The Valley, Napa, California
Kaiser Permanente-Oakland, Oakland, California
Saint Joseph Hospital - Orange, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Palo Alto Medical Foundation Health Care, Palo Alto, California
Kaiser Permanente-Roseville, Roseville, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
Kaiser Permanente Downtown Commons, Sacramento, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Kaiser Permanente-South Sacramento, Sacramento, California
California Protons Cancer Therapy Center, San Diego, California
Sharp Memorial Hospital, San Diego, California
Kaiser Permanente-San Francisco, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
Ridley-Tree Cancer Center, Santa Barbara, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
Kaiser Permanente-Santa Rosa, Santa Rosa, California
City of Hope South Pasadena, South Pasadena, California
Kaiser Permanente-South San Francisco, South San Francisco, California
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California
Cedars-Sinai Cancer - Tarzana, Tarzana, California
City of Hope South Bay, Torrance, California
Torrance Memorial Physician Network - Cancer Care, Torrance, California
Torrance Memorial Medical Center, Torrance, California
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California
City of Hope Upland, Upland, California
Kaiser Permanente-Vallejo, Vallejo, California
Sutter Solano Medical Center/Cancer Center, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
BASS Medical Group - Lennon, Walnut Creek, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado
UCHealth Memorial Hospital Central, Colorado Springs, Colorado
Memorial Hospital North, Colorado Springs, Colorado
Shaw Cancer Center, Edwards, Colorado
Poudre Valley Hospital, Fort Collins, Colorado
Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
UCHealth Greeley Hospital, Greeley, Colorado
UCHealth Highlands Ranch Hospital, Highlands Ranch, Colorado
Medical Center of the Rockies, Loveland, Colorado
Banner McKee Medical Center, Loveland, Colorado
Hartford HealthCare - Saint Vincent's Medical Center, Bridgeport, Connecticut
Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut
Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Hartford Hospital, Hartford, Connecticut
Midstate Medical Center, Meriden, Connecticut
The Hospital of Central Connecticut, New Britain, Connecticut
Yale University, New Haven, Connecticut
Norwalk Hospital, Norwalk, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Beebe South Coastal Health Campus, Millville, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
George Washington University Medical Center, Washington, District of Columbia
Bay Pines VA Healthcare System, Bay Pines, Florida
Boca Raton Regional Hospital, Boca Raton, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Jupiter Medical Center, Jupiter, Florida
GenesisCare USA - Plantation, Plantation, Florida
Cleveland Clinic-Weston, Weston, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Piedmont Hospital, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Emory Decatur Hospital, Decatur, Georgia
Piedmont Fayette Hospital, Fayetteville, Georgia
Northeast Georgia Medical Center-Gainesville, Gainesville, Georgia
Emory Johns Creek Hospital, Johns Creek, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho
Alton Memorial Hospital, Alton, Illinois
Rush - Copley Medical Center, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Illinois CancerCare-Canton, Canton, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Illinois CancerCare-Eureka, Eureka, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
Edward Hines Jr VA Hospital, Hines, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Northwestern Medicine Oak Brook, Oak Brook, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Northwestern Medicine Orland Park, Orland Park, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Advocate High Tech Medical Park, Palos Heights, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
Illinois CancerCare-Peoria, Peoria, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Memorial Hospital East, Shiloh, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Illinois CancerCare - Washington, Washington, Illinois
Saint Luke's Hospital, Cedar Rapids, Iowa
Mercy Hospital, Cedar Rapids, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky
Mary Bird Perkins Cancer Center - Metairie, Metairie, Louisiana
East Jefferson General Hospital, Metairie, Louisiana
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie, Louisiana
MaineHealth Maine Medical Center - Portland, Portland, Maine
Penobscot Bay Medical Center, Rockport, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland, Maine
Luminis Health Anne Arundel Medical Center, Annapolis, Maryland
Maryland Proton Treatment Center, Baltimore, Maryland
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
University of Maryland Shore Medical Center at Easton, Easton, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
UM Capital Region Medical Center, Largo, Maryland
TidalHealth Richard A Henson Cancer Institute, Ocean Pines, Maryland
TidalHealth Peninsula Regional, Salisbury, Maryland
Beverly Hospital, Beverly, Massachusetts
Lahey Hospital and Medical Center, Burlington, Massachusetts
Addison Gilbert Hospital, Gloucester, Massachusetts
Lahey Medical Center-Peabody, Peabody, Massachusetts
Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care, Winchester, Massachusetts
Veteran's Administration Medical Center - Ann Arbor, Ann Arbor, Michigan
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
McLaren Cancer Institute-Bay City, Bay City, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Chelsea Hospital, Chelsea, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
McLaren Cancer Institute-Clarkston, Clarkston, Michigan
Michigan Healthcare Professionals Clarkston, Clarkston, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Michigan Healthcare Professionals Farmington, Farmington Hills, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
McLaren Cancer Institute-Flint, Flint, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Michigan Healthcare Professionals Macomb, Macomb, Michigan
Michigan Healthcare Professionals Madison Heights, Madison Heights, Michigan
McLaren Cancer Institute-Macomb, Mount Clemens, Michigan
McLaren Cancer Institute-Central Michigan, Mount Pleasant, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan
McLaren-Port Huron, Port Huron, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
MyMichigan Medical Center Tawas, Tawas City, Michigan
Munson Medical Center, Traverse City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Michigan Healthcare Professionals Troy, Troy, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
University of Michigan Health - West, Wyoming, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Miller-Dwan Hospital, Duluth, Minnesota
Saint Luke's Hospital of Duluth, Duluth, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
Saint Francis Medical Center, Cape Girardeau, Missouri
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Parkland Health Center - Farmington, Farmington, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
SSM Health Saint Louis University Hospital, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri
Mercy Hospital Springfield, Springfield, Missouri
Missouri Baptist Sullivan Hospital, Sullivan, Missouri
BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri
Billings Clinic Cancer Center, Billings, Montana
Saint James Community Hospital and Cancer Treatment Center, Butte, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Nebraska Medicine-Bellevue, Bellevue, Nebraska
Nebraska Medicine-Village Pointe, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Solinsky Center for Cancer Care, Manchester, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Clara Maass Medical Center, Belleville, New Jersey
Cooper Hospital University Medical Center, Camden, New Jersey
AtlantiCare Surgery Center, Egg Harbor Township, New Jersey
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus, Elizabeth, New Jersey
Englewood Hospital and Medical Center, Englewood, New Jersey
The Cancer Institute of New Jersey Hamilton, Hamilton, New Jersey
Jersey City Medical Center, Jersey City, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Cooper CyberKnife Center, Mount Laurel, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
The Valley Hospital - Luckow Pavilion, Paramus, New Jersey
Sidney Kimmel Cancer Center Washington Township, Sewell, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
Community Medical Center, Toms River, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Lovelace Medical Center-Saint Joseph Square, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Lovelace Radiation Oncology, Albuquerque, New Mexico
Presbyterian Kaseman Hospital, Albuquerque, New Mexico
Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho, New Mexico
Northwell Health Imbert Cancer Center, Bay Shore, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Commack, Commack, New York
Mary Imogene Bassett Hospital, Cooperstown, New York
Noyes Memorial Hospital/Myers Cancer Center, Dansville, New York
Arnot Ogden Medical Center/Falck Cancer Center, Elmira, New York
The New York Hospital Medical Center of Queens, Flushing, New York
Northwell Health Physicians Partners Radiation Medicine at Queens, Forest Hills, New York
Glens Falls Hospital, Glens Falls, New York
Northwell Health Cancer Institute at Huntington, Greenlawn, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Manhattan Eye Ear and Throat Hospital, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Lenox Hill Hospital, New York, New York
Queens Cancer Center, Rego Park, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Phelps Memorial Hospital Center, Sleepy Hollow, New York
Staten Island University Hospital, Staten Island, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Westchester Medical Center, Valhalla, New York
Wilmot Cancer Institute at Webster, Webster, New York
Mission Hospital, Asheville, North Carolina
Duke Cancer Center Cary, Cary, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Durham VA Medical Center, Durham, North Carolina
Duke University Medical Center, Durham, North Carolina
UNC Rex Healthcare, Raleigh, North Carolina
Duke Cancer Center Raleigh, Raleigh, North Carolina
UNC Rex Cancer Center of Wakefield, Raleigh, North Carolina
Novant Cancer Institute Radiation Oncology - Supply, Supply, North Carolina
Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington, North Carolina
Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Broadway Medical Center, Fargo, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Altru Cancer Center, Grand Forks, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Cleveland Clinic Akron General, Akron, Ohio
UH Seidman Cancer Center at UH Avon Health Center, Avon, Ohio
Summa Health System - Barberton Campus, Barberton, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Aultman Health Foundation, Canton, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
Grant Medical Center, Columbus, Ohio
Doctors Hospital, Columbus, Ohio
Delaware Health Center-Grady Cancer Center, Delaware, Ohio
Dublin Methodist Hospital, Dublin, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio
OhioHealth Marion General Hospital, Marion, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
Summa Health Medina Medical Center, Medina, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio
University Hospitals Parma Medical Center, Parma, Ohio
University Hospitals Portage Medical Center, Ravenna, Ohio
North Coast Cancer Care, Sandusky, Ohio
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
South Pointe Hospital, Warrensville Heights, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Saint Charles Health System, Bend, Oregon
Legacy Mount Hood Medical Center, Gresham, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Providence Portland Medical Center, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Legacy Meridian Park Hospital, Tualatin, Oregon
Saint Luke's Cancer Center - Allentown, Allentown, Pennsylvania
UPMC Altoona, Altoona, Pennsylvania
UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem, Pennsylvania
Crozer-Keystone Regional Cancer Center at Broomall, Broomall, Pennsylvania
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Chambersburg Hospital, Chambersburg, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania
Northeast Radiation Oncology Center, Dunmore, Pennsylvania
Saint Luke's Hospital-Anderson Campus, Easton, Pennsylvania
Ephrata Cancer Center, Ephrata, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
Saint Vincent Hospital, Erie, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
Crozer Regional Cancer Center at Brinton Lake, Glen Mills, Pennsylvania
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
IRMC Cancer Center, Indiana, Pennsylvania
Jefferson Hospital, Jefferson Hills, Pennsylvania
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania
Sechler Family Cancer Center, Lebanon, Pennsylvania
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania
Yolanda G Barco Oncology Institute, Meadville, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
Forbes Hospital, Monroeville, Pennsylvania
UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center in Coraopolis, Moon, Pennsylvania
Allegheny Valley Hospital, Natrona Heights, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Jefferson Torresdale Hospital, Philadelphia, Pennsylvania
Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Margaret, Pittsburgh, Pennsylvania
West Penn Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
UPMC-Passavant Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania
Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania
Saint Luke's Hospital - Upper Bucks Campus, Quakertown, Pennsylvania
Saint Luke's Hospital-Quakertown Campus, Quakertown, Pennsylvania
UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania
Saint Luke's Hospital - Monroe Campus, Stroudsburg, Pennsylvania
Chester County Hospital, West Chester, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Wexford Health and Wellness Pavilion, Wexford, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Divine Providence Hospital, Williamsport, Pennsylvania
Asplundh Cancer Pavilion, Willow Grove, Pennsylvania
WellSpan Health-York Cancer Center, York, Pennsylvania
UPMC Memorial, York, Pennsylvania
Saint Joseph's/Candler - Bluffton Campus, Bluffton, South Carolina
Medical University of South Carolina, Charleston, South Carolina
MUSC Health Florence Medical Center, Florence, South Carolina
Saint Francis Hospital, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Self Regional Healthcare, Greenwood, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island, South Carolina
Carolina Regional Cancer Center, Myrtle Beach, South Carolina
Beaufort Memorial/New River Cancer Center, Okatie, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
MD Anderson in The Woodlands, Conroe, Texas
UT Southwestern Simmons Cancer Center - RedBird, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas
M D Anderson Cancer Center, Houston, Texas
MD Anderson West Houston, Houston, Texas
MD Anderson League City, League City, Texas
UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
MD Anderson in Sugar Land, Sugar Land, Texas
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah
Sandra L Maxwell Cancer Center, Cedar City, Utah
Farmington Health Center, Farmington, Utah
Logan Regional Hospital, Logan, Utah
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Utah Valley Regional Medical Center, Provo, Utah
Riverton Hospital, Riverton, Utah
Saint George Regional Medical Center, Saint George, Utah
University of Utah Sugarhouse Health Center, Salt Lake City, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Central Vermont Medical Center/National Life Cancer Treatment, Berlin, Vermont
University of Vermont Medical Center, Burlington, Vermont
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Schar Cancer Institute, Fairfax, Virginia
Inova Fair Oaks Hospital, Fairfax, Virginia
Bon Secours Saint Francis Medical Center, Midlothian, Virginia
Bon Secours Cancer Institute at Reynolds Crossing, Richmond, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Virginia Mason Medical Center, Seattle, Washington
Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver, Washington
Legacy Salmon Creek Hospital, Vancouver, Washington
Providence Saint Mary Regional Cancer Center, Walla Walla, Washington
Langlade Hospital and Cancer Center, Antigo, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Ascension Saint Elizabeth Hospital, Appleton, Wisconsin
Northwest Wisconsin Cancer Center, Ashland, Wisconsin
Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Ascension Calumet Hospital, Chilton, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Ascension Saint Francis - Reiman Cancer Center, Franklin, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Bellin Memorial Hospital, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
ProHealth D N Greenwald Center, Mukwonago, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
Ascension Mercy Hospital, Oshkosh, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Ascension All Saints Hospital, Racine, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Ascension Medical Group Southeast Wisconsin - Mayfair Road, Wauwatosa, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John, New Brunswick
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Conditions: Prostate Adenocarcinoma
Dominantly Inherited Alzheimer Network (DIAN)
Recruiting
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Mayo Clinic Jacksonville, Jacksonville, Florida +24 locations
Mayo Clinic Jacksonville, Jacksonville, Florida
Indiana University-Indiana Alzheimer Disease Center, Indianapolis, Indiana
Brigham and Women's Hospital, Boston, Massachusetts
Washington University in St. Louis School of Medicine, St. Louis, Missouri
Columbia University, New York, New York
University of Pittsburgh, Pittsburgh, Pennsylvania
Butler Hospital, Providence, Rhode Island
University of Washington, Seattle, Washington
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia" (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Not set
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Salta, Not set
Neuroscience Research Australia, Sydney, New South Wales
Mental Health Research Institute, University of Melbourne, Melbourne, Victoria
Sir James McCusker Alzheimer's Disease Research Unit, Edith Cowan University, Perth, Western Australia
Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Not set
McGill University Research Centre for Studies in Aging, Verdun, Quebec
Grupo Neurociencias de Antioquia, Medellín, Not set
German Center for Neurodegenerative Diseases (DZNE) Munich, and University Hospital Ludwig-Maximilians-Universitat (LMU) Munich, Munich, Not set
German Center for Neurodegenerative Diseases (DZNE) Tübingen and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Not set
Niigata University, Niigata, Not set
Osaka City University, Osaka City, Not set
Tokyo University, Tokyo, Not set
Asan Medical Center, Seoul, Songpa-Gu
Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez", Mexico City, México
Hospital Clinic Barcelona, Barcelona, Catalunya
Institute of Neurology, Queen Square, London, Not set
Conditions: Alzheimer's Disease
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Recruiting
This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can reduce the damage to different organs, improve your exercise tolerance and reduce fatigue in people with sickle cell disease.The participants will either get etavopivat or placebo. Which treatment the par... Read More
This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can reduce the damage to different organs, improve your exercise tolerance and reduce fatigue in people with sickle cell disease.The participants will either get etavopivat or placebo. Which treatment the participants will get is decided by chance. Etavopivat is a new medicine and is currently being tested in other studies in addition to this one. The study will last for about 2 years. Read Less
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/14/2025
Locations: Uni of Alabama at Birmingham, Birmingham, Alabama +160 locations
Uni of Alabama at Birmingham, Birmingham, Alabama
Univer South Alabama Ped/Onc, Mobile, Alabama
Phoenix Children's Hsptl, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Children's Hospital Los Angeles - Endocrinology, Los Angeles, California
UCLA Health, Los Angeles, California
Valley Children's Hospital, Madera, California
University Of California Irvine, Orange, California
Stanford University_Palo Alto, Palo Alto, California
Harbor-UCLA Medical Center, Torrance, California
Clinical and Transl Res Center, Aurora, Colorado
Nemours/AI duPont Hosp-Chld, Wilmington, Delaware
Childrens National Medical Ctr, Washington, District of Columbia
MedStar Hlth Res Institute, Washington, District of Columbia
Memorial Healthcare, Hollywood, Florida
Children's Healthcare Atlanta, Atlanta, Georgia
Childrens Hospital of Chicago, Chicago, Illinois
Univer Of Illinois at Chicago, Chicago, Illinois
Children's Hosp-New Orleans, New Orleans, Louisiana
Boston Children's Hospital, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
Henry Ford Hospital_Detroit, Detroit, Michigan
University of Minnesota, Minneapolis, Minnesota
Washington University-St.Louis, Saint Louis, Missouri
Children's Nebraska, Omaha, Nebraska
Cure 4 the Kids Foundation, Las Vegas, Nevada
Newark Beth Israel Medical Center, Newark, New Jersey
Jacobi Medical Center, Bronx, New York
Montefiore Medical Ctr, Bronx, New York
NYC Health+Hospitals, Brooklyn, New York
Interfaith Medical Center, Brooklyn, New York
Northwell Health, Mount Kisco, New York
Cohen Children's Medical Ctr, Queens, New York
Duke Comprehen Sickle Cell, Durham, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina Univ-Greenville, Greenville, North Carolina
Atrium Health-Wake Forest Bapt, Winston-Salem, North Carolina
Univ Hosp Cleveland Med Ctr, Cleveland, Ohio
Ohio State Univ Wexner Med Ctr, Columbus, Ohio
Univ of OK Health Sciences Ctr, Oklahoma City, Oklahoma
Children's Hosptl Philadelphia, Philadelphia, Pennsylvania
St Christopher Hosp for Child, Philadelphia, Pennsylvania
Methodist University Hospital, Memphis, Tennessee
St. Jude Children's Res Hosp, Memphis, Tennessee
UT Health University of Texas, Houston, Texas
Inova Health System, Fairfax, Virginia
Children's Hsptl Of The Kings, Norfolk, Virginia
Virginia Comm Univ Medical Ctr, Richmond, Virginia
Mary Bridge Children's Health, Tacoma, Washington
Mary Bridge Children's Health, Tacoma, Washington
Royal Prince Alfred Hospital, Camperdown, New South Wales
Prince of Wales Hospital - Department of Haematology, Randwick, New South Wales
Monash Health, Clayton, Victoria
Fiona Stanley Hospital - Haemophilia and Haemostasis Centre, Murdoch, Western Australia
CHU Saint-Pierre - UMC Sint-Pieter, Bruxelles, Not set
CHU - UVC Brugmann, Bruxelles, Not set
HUB - Hôpital Erasme, Bruxelles, Not set
UZ Antwerpen - UZA - Haematology, Edegem, Not set
UZ Antwerpen - UZA - Kinderhemato-Oncologie, Edegem, Not set
UZ Leuven - Kindergeneeskunde, Leuven, Not set
MultiHemo - Grupo Oncoclínicas, Recife, Pernambuco
HC da FMUSP Hospital das Clínicas São Paulo, São Paulo, SP
Hemocentro UNICAMP, Distrito De Barão Geraldo - Campinas, São Paulo
Fundação Hemocentro de Ribeirão Preto, Ribeirão Preto, São
Hemorio-Fundarj, Rio de Janeiro, Not set
Hospital Samaritano Higienópolis - Instituto de Conhecimento Ensino e Pesquisa (ICEP), São Paulo, Not set
Foothills Med Ctr-Univ Calgary, Calgary, Alberta
Stollery Children's Hospital, Edmonton, Alberta
University of Alberta_Edmonton, Edmonton, Alberta
BC Children's Hospital, Vancouver, British Columbia
LHSC - Victoria Hospital, London, Ontario
UHN-Toronto General Hospital, Toronto, Ontario
University of Toronto, Toronto, Ontario
CHUM-Hosp de Univ Montreal, Montreal, Quebec
Montreal Children's Hospital, Montreal, Quebec
Hospital Pablo Tobon Uribe, Medellin, Antioquia
Clinica de la Costa, Barranquilla, Atlántico
Sociedad de Oncología y Hematología del Cesar SAS (SOHEC), Valledupar, Cesar
Clínica IMAT Oncomedica Auna S.A.S., Monteria, Córdoba
Centro de investigaciones clínicas, fudación valle del lili, Cali, Valle Del Cauca
Sociedad de Oncología y Hematología del Cesar SAS (SOHEC), Antioquia, Not set
Centro de investigaciones clínicas, fudación valle del lili, Cali, Not set
Clínica IMAT Oncomedica Auna S.A.S., Monteria, Not set
Ap-Hp-Hopital Avicenne, Bobigny, Not set
Centre Hospitalier Universitaire de Bordeaux-Hopital Pellegrin, Bordeaux, Not set
Ap-Hp-Hopital Henri Mondor, Créteil, Not set
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-1, Grenoble cedex 9, Not set
Hospices Civils de Lyon-Hopital Edouard Herriot, Lyon Cedex 03, Not set
Ap-Hp-Hopital Necker-1, Paris, Not set
Ap-Hp-Hopital Robert Debre, Paris, Not set
Centre Hospitalier Universitaire de Rouen-Hopital Charles Nicolle, Rouen cedex, Not set
Agogo Presbyterian Hospital, Ghana, Agogo, Not set
Kintampo Health Research Centre (KHRC), Kintampo, Ghana, Kintampo, Not set
Navrongo Health Research Centre, Ghana, Navrongo, Not set
"Laiko" General Hospital of Athens, Athens, Not set
Childrens' Hospital of Athens "Agia Sofia", Athens, Not set
Hippokration Hospital, Athens, Not set
University General Hospital Of Ioannina, Ioannina, Not set
"AHEPA" University General Hospital of Thessaloniki, Thessaloniki, Not set
Gauhati Medical College and Hospital, Guwahati, Assam
All India Institute of Medical Sciences (AIIMS), Raipur, Raipur, Chhattisgarh
Zydus Medical College & Hospital, Dahod, Gujarat
Nirmal Hospital Pvt. Ltd., Surat, Gujarat
SSG Hospital, Baroda, Vadodara, Gujarat
HOCC Haemato Oncology Care Centre, Vadodara, Gujarat
JSS Hospital, Mysore, Mysuru, Karnataka
Government Medical College, Kozhikode, Kozhikode, Kerala
Arihant Multispeciality Hospital, Nagpur, Maharashtra
IMS and SUM Hospital, Bhubaneswar, Orissa
RNT Medical College, Udaipur, Rajasthan
NIZAM'S Institute of Medical Sciences, Hyderabad, Telangana
Post Graduate Institute of Child Health, Noida, Uttar Pradesh
All India Institute of Medical Sciences_New Dehli, New Delhi, Not set
Azienda Ospedaliera Universitaria San Luigi Gonzaga, Orbassano, Torino
ASST Civili di Brescia, Brescia, Not set
ARNAS (Azienda Ospedaliera di Rilievo Nazionale di Alta Specializzazione) Ospedale Garibaldi, Catania, Not set
A.O. Universitaria di Modena, Modena, Not set
Fondazione IRCCS San Gerardo dei Tintori, Monza, Not set
A.O.U. Università Studi della Campania "Luigi Vanvitelli", Naples, Not set
Azienda Ospedale Universita Padova, Padova, Not set
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo, Not set
Policlinico GB Rossi, Verona, Not set
Ahero Clinical Trials Unit, Kisumu, Kenya, Kisumu, Not set
Gertrude's Children's Hospital, Nairobi, Nairobi, Not set
KEMRI Siaya Clinical Research Annex Siaya County Referral Hospital, Siaya, Siaya, Not set
International Cancer Institute (ICI), Uasin Gishu County, Not set
American University of Beirut Medical Centre, Hamra, Not set
Hospital Nini, Tripoli, Not set
Amsterdam UMC Lokatie VUMC, Amsterdam, Not set
Haga Ziekenhuis, Den Haag, Not set
Erasmus MC, Rotterdam, Not set
UMC Utrecht, Van Creveldkliniek, Utrecht, Not set
University College Hospital Paediatric Haematology and Oncology Unit, Ibadan, Ibadan, Oyo State
Centre for Sickle Cell Disease Research and Training University of Abuja (CESRTA), Abuja, Abuja, Not set
University of Nigeria Teaching Hospital, Enugu, Enugu, Not set
Lagos University Teaching Hospital, Lagos, Lagos, Not set
The Royal Hospital, Muscat, Not set
Sultan Qaboos University Hospital, Muscat, Not set
King Abdulaziz Hospital-Al Ahsa-National Guard, Al Ahsa, Not set
National Guard Hospital Dammam, Dhahran, Not set
King Faisal Specialist Hospital & Research Centre, Riyadh, Riyadh, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Hospital Gregorio Marañón, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Acibadem Adana Hastanesi, Adana, Not set
Baskent Universitesi Adana, Adana, Not set
Cukurova University Medical Faculty, Adana, Not set
Hacettepe University Hematology, Ankara, Not set
Mersin University Medical Faculty Pediatric Hematology, Mersin, Not set
Mersin University Medical Faculty Pediatric Hematology, Mersin, Not set
VM Medical Park Mersin Hospital, Mersin, Not set
Jinja Regional Referral Hospital Children's Ward, Jinja, Not set
Makerere University College of Health Sciences, Kampala, Not set
Joint Clinical Research Centre (JCRC), Kampala, Not set
Addenbrooke's Hospital, Cambridge, Not set
Whittington Hospital, London, Not set
Guy's Hospital, London, Not set
Kings College Hospital, London, Not set
Kings College Hospital, London, Not set
Imperial College London, London, Not set
Conditions: Sickle Cell Disease
Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
Recruiting
This phase III trial compares the usual treatment of surgery after stereotactic radiosurgery (SRS) to receiving SRS before surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation to target tumors and minimizes effect on normal surrounding brain tissue. The combination of surgery and radiation may stop the tumor from growing for a few months or longer and may reduce sy... Read More
This phase III trial compares the usual treatment of surgery after stereotactic radiosurgery (SRS) to receiving SRS before surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation to target tumors and minimizes effect on normal surrounding brain tissue. The combination of surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases. This study investigates whether treating with SRS before surgery may be better than SRS after surgery in reducing the possibility of the tumor coming back, reducing or preventing the cancer from spreading to other areas of the brain and reducing the risk of scarring on the brain from radiation. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Saint Joseph's Hospital and Medical Center, Phoenix, Arizona +212 locations
Saint Joseph's Hospital and Medical Center, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
Kaiser Permanente-Anaheim, Anaheim, California
Sutter Auburn Faith Hospital, Auburn, California
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
Kaiser Permanente-Bellflower, Bellflower, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Memorial Medical Center, Modesto, California
Kaiser Permanente-Ontario, Ontario, California
Saint Joseph Hospital - Orange, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
Sutter Roseville Medical Center, Roseville, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
UCSF Medical Center-Parnassus, San Francisco, California
Sutter Pacific Medical Foundation, Santa Rosa, California
Sutter Solano Medical Center/Cancer Center, Vallejo, California
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Mayo Clinic in Florida, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Miami Cancer Institute, Miami, Florida
Moffitt Cancer Center-International Plaza, Tampa, Florida
Moffitt Cancer Center - McKinley Campus, Tampa, Florida
Moffitt Cancer Center, Tampa, Florida
Moffitt Cancer Center at Wesley Chapel, Wesley Chapel, Florida
Grady Health System, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Piedmont Hospital, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
Pali Momi Medical Center, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
University of Hawaii Cancer Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Castle Medical Center, Kailua, Hawaii
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii
Advocate Outpatient Center - Aurora, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Centralia Oncology Clinic, Centralia, Illinois
Northwestern University, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois
Cancer Care Center of O'Fallon, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
UM Capital Region Medical Center, Largo, Maryland
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Essentia Health Saint Joseph's Medical Center, Brainerd, Minnesota
Essentia Health - Deer River Clinic, Deer River, Minnesota
Essentia Health Cancer Center, Duluth, Minnesota
Essentia Health Saint Mary's Medical Center, Duluth, Minnesota
Miller-Dwan Hospital, Duluth, Minnesota
Essentia Health Hibbing Clinic, Hibbing, Minnesota
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota
Essentia Health Sandstone, Sandstone, Minnesota
Essentia Health Virginia Clinic, Virginia, Minnesota
Parkland Health Center - Farmington, Farmington, Missouri
Saint Luke's Hospital of Kansas City, Kansas City, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri
Mercy Hospital Springfield, Springfield, Missouri
Missouri Baptist Sullivan Hospital, Sullivan, Missouri
BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri
Billings Clinic Cancer Center, Billings, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Cooper Hospital University Medical Center, Camden, New Jersey
Jersey City Medical Center, Jersey City, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
The Valley Hospital - Luckow Pavilion, Paramus, New Jersey
Capital Health Medical Center-Hopewell, Pennington, New Jersey
Valley Health System Ridgewood Campus, Ridgewood, New Jersey
Community Medical Center, Toms River, New Jersey
Valley Health System-Hematology/Oncology, Westwood, New Jersey
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center-Weiler Hospital, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
The New York Hospital Medical Center of Queens, Flushing, New York
Northern Westchester Hospital, Mount Kisco, New York
Mount Sinai Chelsea, New York, New York
Mount Sinai West, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Manhattan Eye Ear and Throat Hospital, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
Lenox Hill Hospital, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Good Samaritan University Hospital, West Islip, New York
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina
CaroMont Regional Medical Center, Gastonia, North Carolina
Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Indu and Raj Soin Medical Center, Beavercreek, Ohio
Case Western Reserve University, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
Grant Medical Center, Columbus, Ohio
Delaware Health Center-Grady Cancer Center, Delaware, Ohio
Grady Memorial Hospital, Delaware, Ohio
Kettering Medical Center, Kettering, Ohio
Mercy Health - Perrysburg Hospital, Perrysburg, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Northeast Radiation Oncology Center, Dunmore, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
UPMC-Presbyterian Hospital, Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Gibbs Cancer Center-Gaffney, Gaffney, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
SMC Center for Hematology Oncology Union, Union, South Carolina
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Covenant Medical Center-Lakeside, Lubbock, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Inova Schar Cancer Institute, Fairfax, Virginia
Henrico Doctor's Hospital, Richmond, Virginia
CJW Medical Center - Johnston-Willis Campus, Richmond, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Carilion Roanoke Memorial Hospital, Roanoke, Virginia
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Duluth Clinic Ashland, Ashland, Wisconsin
Northwest Wisconsin Cancer Center, Ashland, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Essentia Health-Hayward Clinic, Hayward, Wisconsin
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Essentia Health-Spooner Clinic, Spooner, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Essentia Health Saint Mary's Hospital - Superior, Superior, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec
The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec
Hokkaido University Hospital, Sapporo, Hokkaido
Gunma University Hospital, Gunma, Maebashi
Kyoto University Hospital, Kyoto, Not set
National Cancer Center Hospital, Tokyo, Not set
Conditions: Metastatic Malignant Neoplasm in the Brain
Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)
Recruiting
To compare the efficacy and safety in subjects with advanced or metastatic LMS previously treated with an anthracycline.
To compare the efficacy and safety in subjects with advanced or metastatic LMS previously treated with an anthracycline. Read Less
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/14/2025
Locations: Mayo Clinic Arizona, Phoenix, Arizona +29 locations
Mayo Clinic Arizona, Phoenix, Arizona
USC Norris comprehensive cancer center, Los Angeles, California
Stanford University Medical Centre, Palo Alto, California
UCSF, San Francisco, California
UCLA, Santa Monica, California
University of Colorado Cancer Center/ CU Anschutz Medical Campus, Aurora, Colorado
Mayo Clinic Florida, Jacksonville, Florida
University of Miami/ Sylvester Comprehensive Cancer Center, Miami, Florida
Moffitt Cancer Center, Tampa, Florida
Northwestern, Chicago, Illinois
Indiana University, Indianapolis, Indiana
University of Iowa, Iowa City, Iowa
Mass General Brigham Cancer Center, Boston, Massachusetts
University of Michigan, Ann Arbor, Michigan
Mayo Clinic Rochester, Rochester, Minnesota
Washington University School of Medicine - Siteman Cancer Center, Saint Louis, Missouri
Memorial Sloan Kettering Cancer Center, New York, New York
Duke Cancer Institute, Durham, North Carolina
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Cleveland Clinic, Cleveland, Ohio
Ohio State University Wexner Medical Center/ The James Cancer Hospital and Solove Research Institute, Columbus, Ohio
UPenn (Abramson Cancer Center, Pennsylvania Hospital), Philadelphia, Pennsylvania
UPMC Hillman Cancer Center, Pittsburg, Pennsylvania
University of Texas MD Anderson Cancer Center, Houston, Texas
Medical College of Wisconsin/ Froedtert Hospital, Milwaukee, Wisconsin
UHN - Princess Margaret Cancer Center (Ontario), Toronto, Ontario
McGill University Health Centre (Quebec), Montréal, Quebec
Chang Gung Medical Foundation Kaohsiung, Kaohsiung City, Niaosong District
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Conditions: Soft Tissue Sarcoma
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
Recruiting
This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.
This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +208 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Saint Joseph's Hospital and Medical Center, Phoenix, Arizona
Mayo Clinic Hospital in Arizona, Phoenix, Arizona
Mayo Clinic in Arizona, Scottsdale, Arizona
University of Arizona Cancer Center-Orange Grove Campus, Tucson, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
Kaiser Permanente-Anaheim, Anaheim, California
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
Kaiser Permanente-Bellflower, Bellflower, California
Kaiser Permanente Dublin, Dublin, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
Memorial Medical Center, Modesto, California
Kaiser Permanente Oakland-Broadway, Oakland, California
Kaiser Permanente-Ontario, Ontario, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova, California
Rohnert Park Cancer Center, Rohnert Park, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
The Permanente Medical Group-Roseville Radiation Oncology, Roseville, California
Sutter Medical Center Sacramento, Sacramento, California
South Sacramento Cancer Center, Sacramento, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
Kaiser Permanente Cancer Treatment Center, South San Francisco, California
Sutter Solano Medical Center/Cancer Center, Vallejo, California
Hartford Hospital, Hartford, Connecticut
Yale University, New Haven, Connecticut
Helen F Graham Cancer Center, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
TidalHealth Nanticoke / Allen Cancer Center, Seaford, Delaware
Boca Raton Regional Hospital, Boca Raton, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Baptist MD Anderson Cancer Center, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Miami Cancer Institute, Miami, Florida
AdventHealth Orlando, Orlando, Florida
AdventHealth East Orlando, Orlando, Florida
Memorial Hospital West, Pembroke Pines, Florida
Moffitt Cancer Center, Tampa, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Piedmont Hospital, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Northside Hospital-Forsyth, Cumming, Georgia
Piedmont Fayette Hospital, Fayetteville, Georgia
Piedmont Newnan Hospital, Newnan, Georgia
Piedmont Henry Hospital, Stockbridge, Georgia
Queen's Medical Center, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
Decatur Memorial Hospital, Decatur, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
Loyola University Medical Center, Maywood, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
IU Health Methodist Hospital, Indianapolis, Indiana
Iowa Methodist Medical Center, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
LSU Health Sciences Center at Shreveport, Shreveport, Louisiana
MaineHealth Coastal Cancer Treatment Center, Bath, Maine
MaineHealth Maine Medical Center - Portland, Portland, Maine
MaineHealth Cancer Care Center of York County, Sanford, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
Maryland Proton Treatment Center, Baltimore, Maryland
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Tufts Medical Center, Boston, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Chelsea Hospital, Chelsea, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Henry Ford Hospital, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Henry Ford Health Warren Hospital, Warren, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
University of Michigan Health - West, Wyoming, Michigan
Essentia Health Cancer Center, Duluth, Minnesota
Miller-Dwan Hospital, Duluth, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Benefis Sletten Cancer Institute, Great Falls, Montana
Logan Health Medical Center, Kalispell, Montana
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Capital Health Medical Center-Hopewell, Pennington, New Jersey
ProCure Proton Therapy Center-Somerset, Somerset, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
Memorial Sloan Kettering Commack, Commack, New York
The New York Hospital Medical Center of Queens, Flushing, New York
Memorial Sloan Kettering Westchester, Harrison, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Westchester Medical Center, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Case Western Reserve University, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Mercy Cancer Center-Elyria, Elyria, Ohio
Kettering Medical Center, Kettering, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Mount Hood Medical Center, Gresham, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania
Lewistown Hospital, Lewistown, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Temple University Hospital, Philadelphia, Pennsylvania
Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Lankenau Medical Center, Wynnewood, Pennsylvania
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Prisma Health Cancer Institute - Greer, Greer, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
M D Anderson Cancer Center, Houston, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah
Logan Regional Hospital, Logan, Utah
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Utah Valley Regional Medical Center, Provo, Utah
Riverton Hospital, Riverton, Utah
LDS Hospital, Salt Lake City, Utah
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
University of Washington Medical Center - Montlake, Seattle, Washington
Legacy Salmon Creek Hospital, Vancouver, Washington
Langlade Hospital and Cancer Center, Antigo, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Diagnostic and Treatment Center, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
London Regional Cancer Program, London, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec
The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Tata Memorial Hospital, Mumbai, Not set
Hokkaido University Hospital, Sapporo, Hokkaido
Iwate Medical University Hospital, Shiwa-gun, Iwate
Kyorin University Hospital, Mitaka-shi, Tokyo
Keio University, Shinjuku-ku, Tokyo
Hiroshima University Hospital, Hiroshima City, Not set
Saitama Medical University International Medical Center, Saitama, Not set
National Cancer Center Hospital, Tokyo, Not set
King Faisal Specialist Hospital and Research Centre, Riyadh, Not set
Conditions: Intracranial Meningioma, Grade 2 Meningioma
Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation
Recruiting
The current standard for biopsy-based diagnoses of dysfunction of kidney transplants is the Banff Classification which represents arbitrary international consensus. Recent data-driven approaches using molecular and conventional technologies indicate that mere consensus produces frequently incorrect diagnoses with potential harm to patients due to inappropriate treatment. To address this unmet need and improve diagnostics in the area of organ transplantation, the Alberta Transplant Applied Genomi... Read More
The current standard for biopsy-based diagnoses of dysfunction of kidney transplants is the Banff Classification which represents arbitrary international consensus. Recent data-driven approaches using molecular and conventional technologies indicate that mere consensus produces frequently incorrect diagnoses with potential harm to patients due to inappropriate treatment. To address this unmet need and improve diagnostics in the area of organ transplantation, the Alberta Transplant Applied Genomics Centre (ATAGC) has developed a new diagnostic system that combines the molecular and histopathological features of transplant biopsies, plus clinical and laboratory parameters, to create the first Integrated Diagnostic System. The present study will validate and refine this system in 500 prospectively unselected biopsies for clinical indications from American, Canadian and European centres in addition to 300 biopsies already collected. Due to a considerable interest and support from participating Centers, the study is further extended to 1500 prospective biopsies. Thus this is the extension of the INTERCOM study (INTERCOMEX). In addition to demonstrating the feasibility and value of this System in routine patient care and clinical trials, the study will develop and optimize a transparent and user-friendly reporting format to communicate this information to clinicians and obtain detailed feedback on how this system can best improve patient care. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: University of Alabama, Birmingham, Alabama +25 locations
University of Alabama, Birmingham, Alabama
University of Maryland School of Medicine, Baltimore, Maryland
University of Michigan Health System, Ann Arbor, Michigan
University of Minnesota, Minneapolis, Minnesota
Barnes-Jewish Hospital, Saint Louis, Missouri
Montefiore Medical Center, Bronx, New York
Pinnacle Transplant Associates, Harrisburg, Pennsylvania
Texas Transplant Institute - Methodist Healthcare System, San Antonio, Texas
Virginia Commonwealth University School of Medicine, Richmond, Virginia
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Medical University of Vienna, Vienna, Not set
Department of Medicine, University of Alberta, Edmonton, Alberta
University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia
University Hospital Merkur, Zagreb, Not set
Institute for Experimental and Clinical Medicine (IKEM), Prague, Not set
Hopital Necker, Paris, Not set
Hopital St. Louis, Paris, Not set
Charité - Universitätmedizin Berlin, Berlin, Not set
Medizinische Hochschule, Hannover, Not set
Beaumont Hospital, Dublin, Not set
Department of Surgery, University of Usan, College of Medicine, Seoul, Not set
Pomeranian Medical University in Szczecin, Szczecin, Not set
University of Ljubljana, Ljubljana, Not set
Vall d'Hebron Hospital, Barcelona, Not set
University Hospital Zurich, Zürich, Not set
Manchester Royal Infirmary, Manchester, Not set
Conditions: Validation Study of Molecular Diagnostic System, Development of Reporting System for Molecular Diagnosis, Incorporate Molecular Diagnosis Into Diagnostic Standards
A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia
Recruiting
The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in patients with chronic myeloid leukemia with and without T315I mutations in patients who are relapsed, refractory or intolerant to TKIs.
The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in patients with chronic myeloid leukemia with and without T315I mutations in patients who are relapsed, refractory or intolerant to TKIs. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Montefiore Medical Center, Bronx, New York +43 locations
Montefiore Medical Center, Bronx, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Oregon Health & Science University-Knight Cardiovascular Institute, Portland, Oregon
The University of Texas MD Anderson Cancer Center, Houston, Texas
Royal Adelaide Hospital, Adelaide, Not set
UZ Gent, Gent, Not set
CHU Liege, Liège, Not set
University Health Network (UHN) - Princess Margaret Cancer Centre, Toronto, Ontario
CHU Amiens Picardie Site Sud, Amiens, Not set
Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux, Not set
Centre Hospitalier de Versailles (CHV), Le Chesnay, Not set
CHRU de Lille - Hopital Calmette-Boulevard du Pr Leclercq CHRU Lille, Lille, Not set
Centre Hospitalier Universitaire (CHU) De Limoges Hopital Dupuytren, Limoges, Not set
Centre Leon Berard, Lyon, Not set
Centre Hospitalier Lyon Sud, Pierre Benite Cedex, Not set
Uniklinik RWTH Aachen Medizinische, Aachen, Not set
Charite Campus Virchow, Berlin, Not set
Klinikum der Goethe Universitat, Frankfurt, Not set
Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes, Homburg, Not set
Universitaetsklinikum Jena, Jena, Not set
Medizinische Universitatsklinik Mannheim der Universitat Heidelberg, Mannheim, Not set
Universitaetsmedizin Rostock, Rostock, Not set
Semmelweis Egyetem, Belgyogyaszati es Onkologiai Klinika, Budapest, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont (University of Pecs, Clinical Centre), Pécs, Not set
Hadassah Medical Center, Jerusalem, Not set
The Galilee Medical Center, Nahariya, Not set
Rabin Medical Center, Petah Tikva, Not set
Azienda Ospedaliero Universitaria Delle Marche, Ancona, Not set
Chonbuk National University Hospital, Jeonju, Jeollabuk-do
Keimyung University Dongsan Hospital, Daegu, Not set
Uijeongbu Eulji Medical Center, Gyeonggi-do, Not set
Chonnam National University Hwasun Hospital, Hwasun, Not set
Samsung Medical Center, Seoul, Not set
Radboud University Medical Center, Nijmegen, Not set
Szpital Specjalistycnzy im. Jedrzeja Sniadeckiego w Nowym Saczu, Nowy Sącz, Not set
MICS Centrum Medyczne Torun, Toruń, Not set
Hospital Del Mar, Barcelona, Not set
Hospital Universitario de Gran Canaria Dr. Negrin, Servicio Canario e Salud (SCS), Las Palmas De Gran Canaria, Not set
Hospital Universitario La Paz, Madrid, Not set
Complejo Hospitalario de Toledo - Hospital Virgen de la Salud, Toledo, Not set
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia, Not set
Beatson West of Scotland Cancer Centre, Gartnavel General Hospital, Glasgow, Not set
Hammersmith Hospital Imperial College Healthcare NHS Trust, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Cml
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
Recruiting
A Phase 3b, open-label, single-arm, rollover study to evaluate the long-term safety of luspatercept, to the following participants:
* Participants receiving luspatercept on a parent protocol at the time of their transition to the rollover study, who tolerate the protocol-prescribed regimen in the parent trial and, in the opinion of the investigator, may derive clinical benefit from continuing treatment with luspatercept
* Participants in the follow-up phase previously treated with luspatercept... Read More
A Phase 3b, open-label, single-arm, rollover study to evaluate the long-term safety of luspatercept, to the following participants:
* Participants receiving luspatercept on a parent protocol at the time of their transition to the rollover study, who tolerate the protocol-prescribed regimen in the parent trial and, in the opinion of the investigator, may derive clinical benefit from continuing treatment with luspatercept
* Participants in the follow-up phase previously treated with luspatercept or placebo in the parent protocol will continue into long-term post-treatment follow-up in the rollover study until the follow-up commitments are met
* The study design is divided into the Transition Phase, Treatment Phase and Follow-up Phase. Participants will enter transition phase and depending on their background will enter either the treatment phase or the Long-term Post-treatment Follow-up (LTPTFU) phase
* Transition Phase is defined as one Enrollment visit
* Treatment Phase: For participants in luspatercept treatment the dose and schedule of luspatercept in this study will be the same as the last dose and schedule in the parent luspatercept study. This does not apply to participants that are in long-term follow-up from the parent protocol
* Follow-up Phase includes:
- 42 Day Safety Follow-up Visit
* During the Safety Follow up, the participants will be followed for 42 days after the last dose of luspatercept, for the assessment of safety-related parameters and adverse event (AE) reporting
- Long-term Post-treatment Follow-up (LTPTFU) Phase
* Participants will be followed for overall survival every 6 months for at least 5 years from first dose of luspatercept in the parent protocol, or 3 years of post-treatment from last dose, whichever occurs later, or until death, withdrawal of consent, study termination, or until a subject is lost to follow-up. Participants will also be monitored for progression to AML or any malignancies/pre-malignancies. New anticancer or disease related therapies should be collected at the same time schedule
Participants transitioning from a parent luspatercept study in post-treatment follow-up (safety or LTPTFU) will continue from the same equivalent point in this rollover study.
The ACE-536-LTFU-001 rollover study will be terminated, and relevant participants will discontinue from the study when all participants fulfill 5 years on the study, including treatment and follow-up. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Childrens Hospital Los Angeles RHU, Los Angeles, California +142 locations
Childrens Hospital Los Angeles RHU, Los Angeles, California
Local Institution - 971, Oakland, California
Local Institution - 978, Stanford, California
Local Institution - 975, Tampa, Florida
Local Institution - 970, Chicago, Illinois
Local Institution - 973, Boston, Massachusetts
Local Institution - 961, Detroit, Michigan
Local Institution - 969, New York, New York
Local Institution - 967, Cleveland, Ohio
Local Institution - 972, Philadelphia, Pennsylvania
Vanderbilt - Ingram Cancer Center, Nashville, Tennessee
The University of Texas - MD Anderson Cancer Center, Houston, Texas
Local Institution - 100, South Brisbane, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Local Institution - 102, Clayton, Victoria
Royal Prince Alfred Hospital, Camperdown, Not set
Local Institution - 182, Brasschaat, Not set
Local Institution - 180, Brugge, Not set
Local Institution - 183, Ghent, Not set
Local Institution - 184, Leuven, Not set
Local Institution - 220, Boulevard, Sofia
Local Institution - 221, Plovdiv, Not set
Local Institution - 262, Toronto, Ontario
Local Institution - 260, Toronto, Ontario
Local Institution - 263, Toronto, Ontario
Local Institution - 131, Beijing, Beijing
Local Institution - 135, Guangzhou, Guangdong
Local Institution - 132, Shanghai, Shanghai
Local Institution - 134, Chengdu, Sichuan
Local Institution - 130, Tianjin, Tianjin
Local Institution - 133, Hangzhou, Zhejiang
Local Institution - 305, Angers, Not set
Local Institution - 300, Creteil, Not set
Local Institution - 310, La Tronche, Not set
Local Institution - 306, Lille, Not set
Local Institution - 301, Marseille Cedex 9, Not set
Local Institution - 302, Paris, Not set
Local Institution - 307, Pessac Cedex, Not set
Local Institution - 304, Pierre Benite cedex, Not set
Local Institution - 308, Strasbourg, Not set
Local Institution - 309, Toulouse Cedex 9, Not set
Local Institution - 303, Tours, Not set
Local Institution - 341, Berlin, Not set
Local Institution - 348, Dresden, Not set
Local Institution - 345, Duesseldorf, Not set
Local Institution - 346, Dusseldorf, Not set
Local Institution - 343, Halle, Not set
Local Institution - 342, Hamburg, Not set
Local Institution - 344, Hannover, Not set
Local Institution - 349, Leipzig, Not set
Local Institution - 340, Mainz, Not set
Local Institution - 347, München, Not set
Aghia Sophia' Children's General Hospital of Athens, Athens, Not set
Laiko General Hospital of Athens - Center of Thalassemia, Athens, Not set
Local Institution - 384, Athens, Not set
Local Institution - 383, Rio Patras, Not set
Local Institution - 381, Thessaloniki, Not set
Local Institution - 425, Afula, Not set
Rambam Health Corporation, Haifa, Not set
Local Institution - 422, Jerusalem, Not set
Local Institution - 424, Jerusalem, Not set
Local Institution - 421, Nahariya, Not set
Local Institution - 423, Petah Tikva, Not set
Local Institution - 478, Firenze, Toscana
Local Institution - 471, Firenze, Toscana
Local Institution - 470, Allessandria, Not set
Local Institution - 464, Bologna, Not set
Local Institution - 466, Brindisi, Not set
Local Institution - 477, Cagliari, Not set
Local Institution - 462, Ferrara, Not set
Ente Ospedaliero Ospedali Galliera - Centro della Microcitemia e delle Anemie Congenite, Genoa, Not set
Local Institution - 473, Lecce, Not set
Maggiore Polyclinic Hospital, IRCCS Ca' Granda, Milano, Not set
Local Institution - 479, Modena, Not set
AORN A Cardarelli, Napoli, Not set
AOU dell'Universita degli Studi della Campania Luigi Vanvitelli, Napoli, Not set
Azienda Ospedaliero Universitaria S. Luigi Gonzaga, Orbassano, Not set
Local Institution - 469, Pavia, Not set
Local Institution - 468, Reggio Di Calabria, Not set
Local Institution - 465, Roma, Not set
Local Institution - 474, Rozzano, Not set
Local Institution - 472, Varese, Not set
Local Institution - 463, Verona, Not set
Local Institution - 610, Nagoya, Aichi
Local Institution - 601, Kamogawa, Chiba
Matsuyama Red Cross Hospital, Matsuyama, Ehime
Ogaki Municipal Hospital, Ogaki, Gifu
Japanese Red Cross Society Himeji Hospital, Himeji, Hyogo
Local Institution - 605, Hitachi, Ibaraki
Kitasato University Hospital, Sagamihara, Kanagawa
Local Institution - 0979, Sendai, Miyagi
Tohoku University Hospital, Sendai, Miyagi
Local Institution - 611, Nagasaki-shi, Nagasaki
Japanese Red Cross Medical Center, Shibuya City, Tokyo
NTT Medical Center Tokyo, Shinagawa City, Tokyo
Local Institution - 612, Chiba, Not set
Shonan Kamakura General Hospital, Kamakura, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Local Institution - 604, Osaka, Not set
Chronic Care Center, Hazmieh, Not set
Local Institution - 545, Johor Bahru, Johor
Hospital Sultanah Bahiyah, Alor Setar, Kedah
Hospital Raja Permaisuri Bainun, Ipoh, Perak
Queen Elizabeth Hospital, Kota Kinabalu, Sabah
Hospital Umum Sarawak, Kuching, Sarawak
University Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 580, Amsterdam, Not set
Local Institution - 681, Barakaldo, Not set
Local Institution - 686, Barcelona, Not set
Local Institution - 685, Barcelona, Not set
Local Institution - 687, Madrid, Not set
Local Institution - 682, Oviedo, Not set
Local Institution - 684, Salamanca, Not set
Local Institution - 680, Seville, Not set
Local Institution - 683, Valencia, Not set
Local Institution - 720, Goteborg, Not set
Local Institution - 722, Lund, Not set
Local Institution - 721, Stockholm, Not set
Local Institution - 760, Kaohsiung, San Ming Dist., Not set
China Medical University Hospital, Taichung, Not set
Local Institution - 761, Taipei, Not set
Chulalongkorn University Faculty of Medicine - King Chulalongkorn Memorial Hospital, Bangkok, Not set
Siriraj Hospital Mahidol University, Bangkok, Not set
Chiang Mai University - Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Not set
University Hospital Farhat Hached, Sousse, Not set
Bone Marrow Transplant Center, Tunis, Not set
Aziza Othmana Hospital, Tunis, Not set
Military Hospital of Tunis, Tunis, Not set
Acibadem Adana Hospital, Adana, Not set
Local Institution - 885, Ankara, Not set
Local Institution - 882, Istanbul, Not set
Local Institution - 884, Istanbul, Not set
Local Institution - 880, Izmir, Not set
Local Institution - 883, Mersin, Not set
Local Institution - 925, Aberdeen, Not set
Local Institution - 921, Leeds, Not set
Local Institution - 923, London, Not set
Whittington Hospital, London, Not set
University College London Hospitals NHS Foundation Trust - University College Hospital, London, Not set
Local Institution - 928, London, Not set
Local Institution - 924, London, Not set
Local Institution - 929, Oxford, Not set
Local Institution - 926, Sutton in Ashfield, Not set
Conditions: Myelodysplastic Syndromes (MDS), Beta-thalassemia, Myeloproliferative Neoplasm(MPN)-Associated Myelofibrosis
First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
Recruiting
Researchers are looking for a better way to treat participants who have metastatic castration-resistant prostate cancer (mCRPC).
mCRPC is a cancer of the prostate (male reproductive gland found below the bladder) that has spread to other parts of the body. This type of prostate cancer does not respond to hormone treatment used to lower the level of testosterone, a male sex hormone, to prevent cancer from growing.
The study treatment 225Ac-PSMA-Trillium, also called BAY3563254, is under develop... Read More
Researchers are looking for a better way to treat participants who have metastatic castration-resistant prostate cancer (mCRPC).
mCRPC is a cancer of the prostate (male reproductive gland found below the bladder) that has spread to other parts of the body. This type of prostate cancer does not respond to hormone treatment used to lower the level of testosterone, a male sex hormone, to prevent cancer from growing.
The study treatment 225Ac-PSMA-Trillium, also called BAY3563254, is under development to treat advanced metastatic castration-resistant prostate cancer. It works by binding to PSMA and giving off radiation that can damage cancer cells and stop them from growing.
The main purpose of this first-in-human study is to learn:
* How safe is BAY3563254 in participants.
* What is the recommended dose of BAY3563254 that is safe and works well that will be further tested in Part 2 of the study.
* How well does BAY3563254 work in participants.
To answer this, the researchers will look at:
* The number and severity of medical problems including serious medical problems that participants experience after taking BAY3563254
* The number of dose-limiting toxicities (DLT) at each dose level. A DLT is a medical problem caused by a drug that is too severe to continue the use of that specific dose.
* The number of participants whose cancer completely disappears (complete response) or reduces by at least 30% (partial response) after taking the treatment (also known as objective response rate (ORR))
* The number of participants who have a decrease in the levels of PSA\* by at least 50% in their blood (also known as PSA50). PSA is a protein made by the prostate gland. High levels of PSA may indicate the presence of prostate cancer.
* Participants' best response to treatment based on their PSA levels (also known as the best overall PSA response).
The study will have two parts. The first part, called dose escalation, is done to find the most appropriate dose of BAY3563254 for use in the second part of the study. For this, each participant will receive one of different increasing amounts of BAY3563254. They will take BAY3563254 as an injection into a vein. All participants in the second part of the study, called dose expansion, will receive the most appropriate dose of BAY3563254 that was identified from the first part of the study.
Participants in this study will take the study treatment once every 6 weeks, which is known as a treatment cycle. Each participant will have up to 4 of these treatment cycles, if the participant benefits from the treatment. Each participant will be in the study for approximately 6 years, including a screening phase of up to 30 days, 6 months of treatment depending on the participant's benefit, and a follow up phase of 60 months after the end of treatment.
In addition, substudies performed during both dose escalation and dose expansion parts of the study will evaluate:
* the clearance of radioactivity from the body over time
* the doses of radiation that are delivered to normal organs and tumors
During the study, the doctors and their study team will:
* take blood and urine samples
* check vital signs such as blood pressure, heart rate, and body temperature
* examine heart health using electrocardiogram (ECG)
* take tumor samples if required
* check if the participants' cancer has grown and/or spread using CT (computed tomography) or MRI (magnetic resonance imaging) and bone scan
* check the tumor status using PET (positron emission tomography)
* check the amount of radiation absorbed by tumors and normal organs using SPECT/CT (single-photon emission tomography and computed tomography scan)
* ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatments. In addition, the participants will be asked to complete a questionnaire on quality of life at certain time points during the study.
The treatment period ends with a visit in 6-12 weeks after the last BAY3563254 dose. About 6-12 weeks after the last dose and every 6 weeks thereafter, the study doctors and their team will check the participants' health and any changes in their cancer. This active follow-up period ends after 18 months. The long-term follow-up period will start after the end of the active follow-up visit and will continue for up to 60 months after the the last BAY3563254 dose. Participants will be contacted, typically by phone call or clinic visit, approximately every 12 weeks after the end of active follow-up. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: City of Hope, Duarte, California +29 locations
City of Hope, Duarte, California
University of Minnesota Medical Center, Minneapolis, Minnesota
XCancer Omaha, Omaha, Nebraska
University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston, Texas
Institut Jules Bordet / Nuclear Medicine, Anderlecht, Not set
AZ Groeninge Campus Kennedylaan - Urology, Kortrijk, Not set
Cross Cancer Institute, Clinical Trials Unit, Edmonton, Alberta
BC Cancer - Vancouver Site, Vancouver, British Columbia
Juravinski Cancer Centre - Clinical Trials Department, Hamilton, Ontario
Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology, Toronto, Ontario
Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopi, Montreal, Quebec
McGill University Health Centre (MUHC) - Research Institute (RI) - McConnell Centre for Innovative Medicine (CIM), Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke (CHUS) - Hopital Fleurimont, Sherbrooke, Not set
Kuopio University Hospital, Kuopio, Pohjois-Savo
Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Uusimaa
Docrates Mehiläinen Syöpäsairaala, Helsinki, Uusimaa
Tampere University Hospital, Tampere, Not set
Turku University Hospital, Turku, Not set
Istituto Europeo di Oncologia s.r.l - Medicina Nucleare, Milano, Not set
IRCCS Istituto Nazionale Tumori Fondazione Pascale - S. C. Medicina Nucleare e Terapia Metabolica, Napoli, Not set
Universitair Medisch Centrum Groningen (UMCG) - UMC Groningen Comprehensive Cancer Center, Groningen, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
Sahlgrenska Universitetssjukhuset - Klinisk prövningsenhet Fas I/FIH, Göteborg, Not set
Skånes Universitetssjukhus Lund - Onkologens kliniska forskningsenhet, Lund, Not set
Karolinska Universitetssjukhuset - Fas I-enheten Solna CKC, Stockholm, Not set
Akademiska Sjukhuset - Fas-I-enheten, Uppsala, Not set
Kantonsspital Baden, Baden, Aargau
Royal Marsden NHS Trust (Surrey), Sutton, Surrey
University College London Hospitals NHS Foundation Trust, London, Not set
The Newcastle upon Tyne Hospitals NHS Foundation Trust | Freeman Hospital - Cancer Trials Research Centre, Newcastle upon Tyne, Not set
Conditions: Advanced Metastatic Castration-resistant Prostate Cancer, Prostate Specific Membrane Antigen (PSMA) Expression
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