All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT06764875

Recruiting

This is a Phase Ⅲ, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter study assessing the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS ≥ 1. Rilvegostomig in combination with trastuzumab and chemotherapy will be evaluated in a separate arm (Arm C) to... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Research Site, Anchorage, Alaska +264 locations

Research Site, Anchorage, Alaska

Research Site, Duarte, California

Research Site, La Jolla, California

Research Site, Los Alamitos, California

Research Site, Los Angeles, California

Research Site, Santa Barbara, California

Research Site, Santa Monica, California

Research Site, Walnut Creek, California

Research Site, Aurora, Colorado

Research Site, Jacksonville, Florida

Research Site, Orlando, Florida

Research Site, Marietta, Georgia

Research Site, Arlington Heights, Illinois

Research Site, Chicago, Illinois

Research Site, Skokie, Illinois

Research Site, Dyer, Indiana

Research Site, Louisville, Kentucky

Research Site, Silver Spring, Maryland

Research Site, Boston, Massachusetts

Research Site, Grand Rapids, Michigan

Research Site, Burnsville, Minnesota

Research Site, Kansas City, Missouri

Research Site, Saint Louis, Missouri

Research Site, Reno, Nevada

Research Site, Santa Fe, New Mexico

Research Site, New Hyde Park, New York

Research Site, New York, New York

Research Site, Cincinnati, Ohio

Research Site, Knoxville, Tennessee

Research Site, Nashville, Tennessee

Research Site, Dallas, Texas

Research Site, Webster, Texas

Research Site, Fairfax, Virginia

Research Site, Richmond, Virginia

Research Site, Madison, Wisconsin

Research Site, Buenos Aires, Not set

Research Site, Ciudad Autónoma Buenos Aires, Not set

Research Site, Rosario, Not set

Research Site, Viedma, Not set

Research Site, Darlinghurst, Not set

Research Site, Heidelberg, Not set

Research Site, Murdoch, Not set

Research Site, Westmead, Not set

Research Site, Linz, Not set

Research Site, Salzburg, Not set

Research Site, Wiener Neustadt, Not set

Research Site, Wien, Not set

Research Site, Edegem, Not set

Research Site, Gent, Not set

Research Site, Leuven, Not set

Research Site, Liège, Not set

Research Site, Barretos, Not set

Research Site, Brasilia, Not set

Research Site, Campo Grande, Not set

Research Site, Natal, Not set

Research Site, Porto Alegre, Not set

Research Site, Recife, Not set

Research Site, Salvador, Not set

Research Site, Sao Paulo, Not set

Research Site, Vitória, Not set

Research Site, Calgary, Alberta

Research Site, Edmonton, Alberta

Research Site, Winnipeg, Manitoba

Research Site, Barrie, Ontario

Research Site, Hamilton, Ontario

Research Site, Toronto, Ontario

Research Site, Montreal, Quebec

Research Site, Chicoutimi, Not set

Research Site, Puerto Montt, Not set

Research Site, Rancagua, Not set

Research Site, Santiago, Not set

Research Site, Temuco, Not set

Research Site, Viña del Mar, Not set

Research Site, Anyang, Not set

Research Site, Beijing, Not set

Research Site, Bengbu, Not set

Research Site, Changchun, Not set

Research Site, Changsha, Not set

Research Site, Chengdu, Not set

Research Site, Fuzhou, Not set

Research Site, Guangzhou, Not set

Research Site, Hangzhou, Not set

Research Site, Harbin, Not set

Research Site, Hefei, Not set

Research Site, Jinan, Not set

Research Site, Kunming, Not set

Research Site, Lanzhou, Not set

Research Site, Linfen, Not set

Research Site, Linyi, Not set

Research Site, Nanchang, Not set

Research Site, Nanjing, Not set

Research Site, Shandong, Not set

Research Site, Shanghai, Not set

Research Site, Shenyang, Not set

Research Site, Shijiazhuang, Not set

Research Site, Tianjin, Not set

Research Site, Wenzhou, Not set

Research Site, Wuhan, Not set

Research Site, Xi'an, Not set

Research Site, Xian, Not set

Research Site, Xining, Not set

Research Site, Yinchuan, Not set

Research Site, Zhengzhou, Not set

Research Site, Bordeaux, Not set

Research Site, Caen Cedex 5, Not set

Research Site, Clermont-Ferrand, Not set

Research Site, Dijon, Not set

Research Site, Lyon, Not set

Research Site, Marseille, Not set

Research Site, Poitiers, Not set

Research Site, Rennes, Not set

Research Site, Toulouse, Not set

Research Site, Villejuif Cedex, Not set

Research Site, Augsburg, Not set

Research Site, Bad Saarow, Not set

Research Site, Berlin, Not set

Research Site, Braunschweig, Not set

Research Site, Chemnitz, Not set

Research Site, Düsseldorf, Not set

Research Site, Essen, Not set

Research Site, Frankfurt, Not set

Research Site, Göttingen, Not set

Research Site, Hamburg, Not set

Research Site, Leipzig, Not set

Research Site, Ludwigshafen, Not set

Research Site, Mannheim, Not set

Research Site, Ulm, Not set

Research Site, Hong Kong, Not set

Research Site, Shatin, Not set

Research Site, Budapest, Not set

Research Site, Gyula, Not set

Research Site, Gyöngyös, Not set

Research Site, Győr, Not set

Research Site, Zalaegerszeg, Not set

Research Site, Bangalore, Not set

Research Site, Delhi, Not set

Research Site, Hyderabad, Not set

Research Site, Kolkata, Not set

Research Site, Mumbai, Not set

Research Site, Varanasi, Not set

Research Site, Cagliari, Not set

Research Site, Firenze, Not set

Research Site, Milano, Not set

Research Site, Napoli, Not set

Research Site, Padova, Not set

Research Site, Rozzano, Not set

Research Site, Torino, Not set

Research Site, Tricase, Not set

Research Site, Akashi-shi, Not set

Research Site, Bunkyo-ku, Not set

Research Site, Chuo-ku, Not set

Research Site, Fukuoka-shi, Not set

Research Site, Hidaka-shi, Not set

Research Site, Hirakata-shi, Not set

Research Site, Hiroshima-shi, Not set

Research Site, Kasama-shi, Not set

Research Site, Kita-gun, Not set

Research Site, Kitaadachi-gun, Not set

Research Site, Koto-ku, Not set

Research Site, Matsuyama-shi, Not set

Research Site, Niigata-shi, Not set

Research Site, Osaka-shi, Not set

Research Site, Osakasayama-shi, Not set

Research Site, Ota-shi, Not set

Research Site, Sendai-shi, Not set

Research Site, Shiwa-gun, Not set

Research Site, Suita-shi, Not set

Research Site, Sunto-gun, Not set

Research Site, Toyoake-shi, Not set

Research Site, Yokohama-shi, Not set

Research Site, Daegu, Not set

Research Site, Goyang-si, Not set

Research Site, Gyeonggi-do, Not set

Research Site, Jeonnam, Not set

Research Site, Seoul, Not set

Research Site, Georgetown, Not set

Research Site, Ipoh, Not set

Research Site, Kuala Lumpur, Not set

Research Site, Sabah, Not set

Research Site, Amsterdam, Not set

Research Site, Arnhem, Not set

Research Site, Leiden, Not set

Research Site, Arequipa, Not set

Research Site, Callao, Not set

Research Site, Lima, Not set

Research Site, San Isidro, Not set

Research Site, Białystok, Not set

Research Site, Gdańsk, Not set

Research Site, Koszalin, Not set

Research Site, Olsztyn, Not set

Research Site, Przemysl, Not set

Research Site, Warszawa, Not set

Research Site, Wrocław, Not set

Research Site, Rio Piedras, Not set

Research Site, Badalona, Not set

Research Site, Barcelona, Not set

Research Site, Madrid, Not set

Research Site, Orense, Not set

Research Site, Santander, Not set

Research Site, Sevilla, Not set

Research Site, Valencia, Not set

Research Site, Kaohsiung, Not set

Research Site, Taichung, Not set

Research Site, Tainan, Not set

Research Site, Taipei, Not set

Research Site, Taoyuan, Not set

Research Site, Bangkok, Not set

Research Site, Banphaeo, Not set

Research Site, Dusit, Not set

Research Site, Khon Kaen, Not set

Research Site, Ankara, Not set

Research Site, Antalya, Not set

Research Site, Diyarbakir, Not set

Research Site, Erzurum, Not set

Research Site, Istanbul, Not set

Research Site, Izmir, Not set

Research Site, Mezitli, Not set

Research Site, Cambridge, Not set

Research Site, Coventry, Not set

Research Site, Dundee, Not set

Research Site, London, Not set

Research Site, Manchester, Not set

Research Site, Sutton, Not set

Research Site, Hanoi, Not set

Research Site, Ho Chi Minh city, Not set

Research Site, Viet Tri, Not set

Research Site, Vinh, Not set

Conditions: HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma

Learn More ›

Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II

NCT06467084

Recruiting

KVD900-303 is an open-label, multicenter clinical trial in patients aged 2 to 11 years old with HAE Type I or II.

Gender:

ALL

Ages:

Between 2 years and 11 years

Trial Updated:

07/09/2025

Locations: KalVista Investigative Site, Birmingham, Alabama +23 locations

Conditions: Hereditary Angioedema

Learn More ›

Study to Assess Function and Satisfaction of Oral Ubrogepant in Adult Participants After Multiple Migraine Attacks In Canada

NCT06692881

Recruiting

Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will evaluate function and satisfaction with oral ubrogepant in treating adult participants after multiple migraine attacks. Ubrogepant is a drug approved for the acute treatment of migraine in adults. Approximately 167 participants will be enrolled in approximately 10-15 sites across Canada. Participants will receive ubrogepant as... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Calgary Headache Assessment and Management Program /ID# 271475, Calgary, Alberta +9 locations

Conditions: Migraine

Learn More ›

Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents

NCT05867472

Recruiting

The goal of a pilot study is to test a study plan to see if it is appropriate for a larger study. This study plan is looking at whether the use of inhaled sedatives (medications that help people be calm and sleep) can reduce delirium (extreme confusion) in children who need a ventilator (breathing machine) compared to IV or oral sedatives. The main question\[s\] it aims to answer are: * Will people join the study? (recruitment) * Will participants finish the study? * Will healthcare teams acce... Read More

Gender:

ALL

Ages:

Between 1 month and 18 years

Trial Updated:

07/09/2025

Locations: McMaster Children's Hospital, Hamilton, Ontario +2 locations

Conditions: Intensive Care Units, Pediatric, Anesthetics, Inhalation, Mechanically Ventilated, Critically Ill Children

Learn More ›

A Study to Test the Benefit of Vitamin B5 in Patients With Melanoma

NCT06377111

Recruiting

This study is open to patients with a type of cancer called melanoma. Patients can join the study if their tumor cannot be removed by surgery or has spread to other organs, and are planned to receive immunotherapy as treatment for their cancer. This study is looking at whether taking calcium pantothenate supplement (a type of Vitamin B5) can increase its levels in the blood and have an effect in the immune system, when its used in combination with the immunotherapy.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: University Health Network- Princess Margaret Cancer Centre, Toronto, Ontario

Conditions: Melanoma (Skin)

Learn More ›

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

NCT05172973

Recruiting

The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.

Gender:

ALL

Ages:

All

Trial Updated:

07/09/2025

Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California +34 locations

Hoag Memorial Hospital Presbyterian, Newport Beach, California

Bay Area Structural Heart at Sutter Health, San Francisco, California

Kaiser San Francisco, San Francisco, California

Stanford University Medical Center, Stanford, California

UC Health Medical Center of the Rockies, Loveland, Colorado

Naples Community Hospital Healthcare System, Naples, Florida

Emory University Atlanta, Atlanta, Georgia

Piedmont Heart Institute, Atlanta, Georgia

Northwestern University Chicago, Evanston, Illinois

Alexian Brothers Hospital Network, Lisle, Illinois

Cardiovascular Research Institute of Kansas, Wichita, Kansas

MedStar Union Memorial Hospital, Baltimore, Maryland

Brigham and Women's Hospital, Boston, Massachusetts

Henry Ford Hospital Detroit, Detroit, Michigan

Mayo Clinic, Rochester, Minnesota

Atlantic Health System Morristown, Morristown, New Jersey

Robert Wood Johnson University Hospital, New Brunswick, New Jersey

The Valley Hospital, Ridgewood, New Jersey

University of Buffalo, Buffalo, New York

Cornelll University New York, New York, New York

Columbia University Medical Center / NYPH, New York, New York

Rochester General Hospital, Rochester, New York

Carolinas Health System, Charlotte, North Carolina

Novant Health and Vascular Institute, Charlotte, North Carolina

The Christ Hospital, Cincinnati, Ohio

The Cleveland Clinic Foundation, Cleveland, Ohio

Oklahoma Heart Institute, Tulsa, Oklahoma

Allegheny General Hospital, Pittsburgh, Pennsylvania

Saint Thomas Health, Nashville, Tennessee

University of Texas Memorial Hermann, Houston, Texas

The Heart Hospital Baylor Plano, Plano, Texas

University of Washington Seattle, Seattle, Washington

St. Paul's Hospital Vancouver, Vancouver, British Columbia

Hamilton Health Sciences, Hamilton, Ontario

Institut Universitaire de Cardiologie et de Pneumologie de Québec- Universite Laval, Québec, Quebec

Conditions: Aortic Valve Insufficiency, Aortic Valve Stenosis

Learn More ›

The Fourth Left Atrial Appendage Occlusion Study

NCT05963698

Recruiting

LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Affinity Hospital dba Grandview Medical Center, Birmingham, Alabama +63 locations

Affinity Hospital dba Grandview Medical Center, Birmingham, Alabama

Arrhythmia Research Group, Jonesboro, Arkansas

Memorial Health Services, Fountain Valley, California

Loma Linda University Health, Loma Linda, California

Sutter Valley Hospitals dba Sutter Institute for Medical Research, Sacramento, California

St. Vincent's Health System, Jacksonville, Florida

St Luke's Regional Medical Center, Ltd, Boise, Idaho

Kootenai Health Inc., Coeur d'Alene, Idaho

Northwestern University, Evanston, Illinois

Cardiovascular Medicine, PLLC and Unity Point Trinity Rock Island, Rock Island, Illinois

Community Health Network Inc., Indianapolis, Indiana

MercyOne Iowa Heart Center, West Des Moines, Iowa

University of Kansas Medical Center Research Institute, Inc., Kansas City, Kansas

Babtist Health Lexington, Lexington, Kentucky

Ochsner Clinic Foundation, New Orleans, Louisiana

University of Maryland Baltimore, Baltimore, Maryland

Lahey Clinic Inc., Burlington, Massachusetts

University of Michigan, Ann Arbor, Michigan

Henry Ford Health System, Detroit, Michigan

The Feinstein Institutes for Medical Research, Manhasset, New York

NYU Grossman School of Medicine, New York, New York

Cornell University for and on behalf of its Joan & Sanford I. Weill Medical College and The New York Presbyterian Hospital, New York, New York

Mission Hospital HCA, Asheville, North Carolina

Aultman Hospital, Canton, Ohio

TriHealth Inc., Cincinnati, Ohio

Cleveland Clinic, Cleveland, Ohio

Texas Cardiac Arrhythmia Research Foundation, Austin, Texas

Baylor Research Institute, Dallas, Texas

Heart Rhythm Associates, The Woodlands, Texas

CHRISTUS Northeast Texas Health System, Tyler, Texas

The Rector and Visitors of the University of Virginia, Charlottesville, Virginia

The Medical College of Wisconsin, Milwaukee, Wisconsin

University of Calgary, Calgary, Alberta

Vancouver Coastal Health Authority, Vancouver, British Columbia

St. Boniface Hospital Inc., Winnipeg, Manitoba

Circulate Cardiac & Vascular Centre (CCVC), Burlington, Ontario

Cambridge Cardiac Care Inc., Cambridge, Ontario

Hamilton Health Sciences Corp, Hamilton, Ontario

Waterloo Wellington Cardiovascular Research Institute (WWCRI), Kitchener, Ontario

Lawson Health Research Institute, London, Ontario

Southlake Regional Health Centre, Newmarket, Ontario

Partners in Advanced Cardiac Evaluation (PACE), Newmarket, Ontario

Ottawa Heart Institute Research Corp, Ottawa, Ontario

Niagara Health Systems - St. Catharines, St Catharines, Ontario

Niagara Health System - Niagara Falls, St. Catharines, Ontario

Sunnybrook Health Sciences Center, Toronto, Ontario

Lawrence Park Cardiology, Toronto, Ontario

Institut de Cardiologie de Montreal (ICM), Montréal, Quebec

Centre hospitalier de l'Université de Montréal, Montréal, Quebec

Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Québec, Quebec

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS), Sherbrooke, Quebec

Prairie Valscular Research Inc. (PVRI), Regina, Saskatchewan

Saskatchewan Health Authority, Saskatoon, Saskatchewan

Region Hospital Viborg, Viborg, Midtjylland

Aarhus University Hospital (AUH), Aarhus, Region Midt

Infirmerie Protestante de Lyon, Caluire-et Cuire, Rhone Alpes

L'Assistance Publique - Hôpitaux de Paris, Paris, Not set

CVC Rhein-Main GmbH, Frankfurt, Hessen

MVZ CCB Frankfurt und Main-Taunus GbR, Frankfurt, Hessen

Krankenhausbetriebsgesellschaft Bad Oeynhausen mbH, Bad Oeynhausen, NRW

Westpfalz-Klinikum GmbH, Kaiserslautern, Rheinland-Pfalz

Katholisches Krankenhaus "St. Johann Nepomuk", Erfurt, Thuringen

Charité Universitätsmedizin Berlin, Berlin, Not set

Asklepios Kliniken Hamburg GmbH, Hamburg, Not set

Conditions: Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism

Learn More ›

Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)

NCT06593600

Recruiting

This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * How the study drug changes heart rate and blood pressure in participants with POTS * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether... Read More

Gender:

ALL

Ages:

Between 18 years and 55 years

Trial Updated:

07/09/2025

Locations: Mercy Gilbert Medical Center, Gilbert, Arizona +17 locations

Conditions: Postural Orthostatic Tachycardia Syndrome (POTS)

Learn More ›

Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension

NCT06492291

Recruiting

This is an extension study to evaluate the longer-term safety and efficacy of enlicitide decanoate in adults with hypercholesterolemia who completed either study MK-0616-013 (NCT05952856), study MK-0616-017 (NCT05952869), or study MK-0616-018 (NCT06450366).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Alliance for Multispecialty Research, LLC ( Site 0027), Daphne, Alabama +221 locations

Alliance for Multispecialty Research, LLC ( Site 0027), Daphne, Alabama

G&L Research ( Site 0035), Foley, Alabama

Synexus Clinical Research US, Inc.-Synexus Clinical Research US, Inc - Central Phoenix ( Site 0048), Phoenix, Arizona

National Heart Institute-Research ( Site 0029), Beverly Hills, California

Clinical Trials Research ( Site 0054), Sacramento, California

Velocity Clinical Research, Banning ( Site 0023), San Bernardino, California

Emerson Clinical Research Institute ( Site 0017), Washington, District of Columbia

Excel Medical Clinical Trials ( Site 0010), Boca Raton, Florida

Alliance for Multispecialty Research, LLC ( Site 0037), Coral Gables, Florida

Alliance for Multispecialty Research, LLC ( Site 0056), Fort Myers, Florida

Velocity Clinical Research, Hallandale Beach ( Site 0053), Hallandale Beach, Florida

Jacksonville Center for Clinical Research ( Site 0025), Jacksonville, Florida

South Broward Research ( Site 0012), Miramar, Florida

Progressive Medical Research ( Site 0033), Port Orange, Florida

Clinical Research Trials of Florida ( Site 0006), Tampa, Florida

Clinical Site Partners, LLC dba Flourish Research ( Site 0004), Winter Park, Florida

East Coast Institute for Research, LLC ( Site 0020), Macon, Georgia

Healthcare Research Network - Chicago ( Site 0051), Flossmoor, Illinois

Synexus Clinical Research US - Evansville ( Site 0005), Evansville, Indiana

Midwest Institute For Clinical Research ( Site 0052), Indianapolis, Indiana

Alliance for Multispecialty Research, LLC ( Site 0001), Lexington, Kentucky

L-MARC Research Center ( Site 0011), Louisville, Kentucky

Velocity Clinical Research, Covington ( Site 0026), Covington, Louisiana

Velocity Clinical Research Rockville ( Site 0022), Rockville, Maryland

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0018), Troy, Michigan

Velocity Clinical Research, Gulfport ( Site 0032), Gulfport, Mississippi

Healthcare Research Network - St. Louis ( Site 0040), Hazelwood, Missouri

Velocity Clinical Research at The Pioneer Heart Institute, Lincoln ( Site 0031), Lincoln, Nebraska

Jubilee Clinical Research ( Site 0049), Las Vegas, Nevada

AB Clinical Trials ( Site 0002), Las Vegas, Nevada

New Mexico Clinical Research & Osteoporosis Center ( Site 0043), Albuquerque, New Mexico

Velocity Clinical Research, Syracuse ( Site 0014), East Syracuse, New York

Icahn School of Medicine at Mount Sinai-Cardiology ( Site 0042), New York, New York

Lillestol Research ( Site 0030), Fargo, North Dakota

altoona center for clinical research ( Site 0024), Duncansville, Pennsylvania

Cardiology Consultants of Philadelphia Yardley ( Site 0021), Yardley, Pennsylvania

Velocity Clinical Research, Anderson ( Site 0015), Anderson, South Carolina

Piedmont Research Partners ( Site 0045), Fort Mill, South Carolina

Coastal Carolina Research Center ( Site 0055), North Charleston, South Carolina

Monument Health Clinical Research, a department of Monument -Monument Health Clinical Research, a d ( Site 0038), Rapid City, South Dakota

Holston Medical Group ( Site 0034), Kingsport, Tennessee

Alliance for Multispecialty Research, LLC ( Site 0050), Knoxville, Tennessee

Velocity Clinical Research, Dallas ( Site 0028), Dallas, Texas

Center for Cardiometabolic Disease Prevention/Baylor College of Medicine ( Site 0009), Houston, Texas

Clinical Trials of Texas, LLC ( Site 0016), San Antonio, Texas

Synexus Clinical Research US, Inc. ( Site 0003), Salt Lake City, Utah

Velocity Clinical Research, Salt Lake City ( Site 0041), West Jordan, Utah

Manassas Clinical Research Center ( Site 0007), Manassas, Virginia

Health Research of Hampton Roads, Inc. ( Site 0019), Newport News, Virginia

Alliance for Multispecialty Research, LLC ( Site 0008), Norfolk, Virginia

National Clinical Research, Inc ( Site 0044), Richmond, Virginia

Rainier Clinical Research Center ( Site 0013), Renton, Washington

CEDIC ( Site 0603), Caba, Buenos Aires

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0605), Caba, Buenos Aires

Fundación Respirar ( Site 0606), Caba, Buenos Aires

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0602), Mar del Plata, Buenos Aires

Instituto de Investigaciones Clinicas Zarate ( Site 0604), Zárate, Buenos Aires

Fundacion Estudios Clinicos ( Site 0601), Rosario, Santa Fe

Centro de Investigaciones Metabolicas CINME - Cardiology ( Site 0607), Caba, Not set

CIPREC ( Site 0600), Caba, Not set

Royal Prince Alfred Hospital-6West CV Ambulatory Care ( Site 2808), Camperdown, New South Wales

Victorian Heart Hospital-Monash Cardiovascular Research Centre (MCRC) ( Site 2803), Clayton, Victoria

Universidade Federal Do Ceara ( Site 0702), Fortaleza, Ceara

Instituto Dante Pazzanese de Cardiology ( Site 0701), São Paulo, Sao Paulo

Incor - Instituto do Coracao ( Site 0703), Sao Paulo, Not set

The Medical Arts Health Research Group ( Site 0506), North Vancouver, British Columbia

Cambridge Cardiac Care Centre ( Site 0502), Cambridge, Ontario

North York Diagnostic and Cardiac Centre ( Site 0505), North York, Ontario

Ecogene-21 ( Site 0500), Chicoutimi, Quebec

Institut de Cardiologie de Montreal ( Site 0504), Montreal, Quebec

Diex Recherche Trois-Rivieres ( Site 0503), Trois-Rivieres, Quebec

Clinical Research Chile SpA ( Site 0800), Valdivia, Los Rios

CDIEM ( Site 0801), Providencia, Region M. De Santiago

Pontificia Universidad Catolica de Chile-CICUC ( Site 0803), Santiago, Region M. De Santiago

Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 6000), Beijing, Beijing

Beijing Friendship Hospital Affiliate of Capital University ( Site 6003), Beijing, Beijing

The Second Affiliated Hospital of Chongqing Medical University ( Site 6020), Chongqing, Chongqing

Chongqing University Three Gorges Hospital ( Site 6021), Chongqing, Chongqing

Guangdong Provincial People s Hospital ( Site 6004), Guangzhou, Guangdong

Zhujiang Hospital ( Site 6029), Guangzhou, Guangdong

Huizhou Municipal Central Hospital ( Site 6079), Huizhou, Guangdong

The University of Hong Kong-Shenzhen Hospital ( Site 6018), Shenzhen, Guangdong

Jingzhou Central Hospital ( Site 6076), Jingzhou, Hubei

Wuhan Fourth Hospital ( Site 6056), Wuhan, Hubei

Hunan Provincial People's Hospital ( Site 6017), Changsha, Hunan

Changzhou Second People's Hospital ( Site 6073), Changzhou, Jiangsu

Northern Jiangsu People s Hospital ( Site 6008), Yangzhou, Jiangsu

The Third Hospital of Nanchang - Fuhe ( Site 6078), Nanchang, Jiangxi

Siping Central People's Hospital ( Site 6011), Siping, Jilin

Xianyang Hospital of Yan'an University ( Site 6040), Xianyang City, Shaanxi

Chengdu Second Municipal People's Hospital ( Site 6032), Chengdu, Sichuan

Lishui City People s Hospital ( Site 6002), Lishui, Zhejiang

Fundación Centro de Investigación Clínica CIC ( Site 0904), Medellín, Antioquia

Ciensalud Ips S A S ( Site 0900), Barranquilla, Atlantico

Clinica de la Costa S.A.S. ( Site 0901), Barranquilla, Atlantico

Salud SURA Calle 100 ( Site 0905), Bogotá, Cundinamarca

Healthy Medical Center S.A.S ( Site 0902), Zipaquira, Cundinamarca

Fundación Valle del Lili ( Site 0903), Cali, Valle Del Cauca

Fakultni Nemocnice u sv. Anny v Brne ( Site 3604), Brno, Brno-mesto

Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 3602), Brno, Brno-mesto

Institut Klinicke a Experimentalni Mediciny ( Site 3601), Prague, Praha 4

Meilahden tornisairaala - Meilahti Tower Hospital ( Site 1300), Helsinki, Uusimaa

Hôpital Arnaud de Villeneuve - CHU Montpellier ( Site 5002), Montpellier, Herault

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes ( Site 5004), Saint-Herblain, Loire-Atlantique

Hospices Civils de Lyon - Hopital Louis Pradel-Service d'endocrinologie, de diabétologie et des mal ( Site 5000), Bron, Rhone

Unterfrintroper Hausarztzentrum Klinische Forschung ( Site 1543), Essen, Nordrhein-Westfalen

Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels ( Site 1528), Hohenmoelsen, Sachsen-Anhalt

Universitaetsklinikum Carl Gustav Carus Dresden-Universitätsstudienzentrum für Stoffwechselerkranku ( Site 1510), Dresden, Sachsen

Zentralklinik Bad Berka ( Site 1531), Bad Berka, Thuringen

Velocity Clinical Research GmbH Berlin ( Site 1503), Berlin, Not set

Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 1534), Berlin, Not set

Queen Mary Hospital-Medical ( Site 3300), Hksar, Not set

Prince of Wales Hospital ( Site 3304), Shatin, Not set

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1603), Szeged, Csongrad

Semmelweis Egyetem-Városmajori Szív- és Érgyógyászati Klinika ( Site 1600), Budapest, Not set

Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Anyagcsere Tanszék) ( Site 1601), Debrecen, Not set

Hillel Yaffe Medical Center ( Site 1731), Hadera, Not set

Rambam Health Care Campus ( Site 1739), Haifa, Not set

Rambam Health Care Campus ( Site 1742), Haifa, Not set

Shaare Zedek Medical Center ( Site 1735), Jerusalem, Not set

Hadassah Medical Center ( Site 1732), Jerusalem, Not set

Hadassah Medical Center ( Site 1741), Jerusalem, Not set

Hadassah Medical Center-Heart Institute ( Site 1734), Jerusalem, Not set

Meir Medical Center. ( Site 1737), Kfar Saba, Not set

Rabin Medical Center ( Site 1738), Petah Tikva, Not set

Rabin Medical Center ( Site 1740), Petah Tikva, Not set

Sheba Medical Center ( Site 1733), Ramat Gan, Not set

Clalit Health Services - Sakhnin Community Clinic ( Site 1730), Sakhnin, Not set

Yitzhak Shamir Medical Center. ( Site 1736), Zerifin, Not set

Fondazione Policlinico Tor Vergata ( Site 1809), Rome, Lazio

Centro Cardiologico Monzino ( Site 1804), Milan, Milano

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1801), Torino, Piemonte

Azienda Ospedaliera Sant'Andrea-Department of Clinical and Molecular Medicine ( Site 1807), Rome, Roma

Azienda Ospedaliera Garibaldi ( Site 1810), Catania, Not set

Hirohata Naika Clinic ( Site 3513), Kitakyushu, Fukuoka

Nakakinen clinic ( Site 3510), Naka, Ibaraki

Noritake Clinic ( Site 3512), Ushiku, Ibaraki

National Hospital Organization Kanazawa Medical Center ( Site 3508), Kanazawa, Ishikawa

Hirano Medical Clinic ( Site 3522), Morioka, Iwate

Shirai Healthcare Clinic Izumichuou ( Site 3527), Sendai, Miyagi

Rinku General Medical Center ( Site 3503), Izumisano, Osaka

Shiraiwa Medical Clinic ( Site 3514), Kashiwara, Osaka

Medical Corporation Heishinkai OCROM Clinic ( Site 3501), Suita-shi, Osaka

Saitama Medical University Hospital ( Site 3506), Iruma, Saitama

Teramoto Medical and Dental Clinic ( Site 3507), Bunkyo-ku, Tokyo

Tokyo-Eki Center-building Clinic ( Site 3505), Chuo-ku, Tokyo

Fukuwa Clinic ( Site 3504), Chuo-ku, Tokyo

Teikyo University Hospital ( Site 3500), Itabashi-ku, Tokyo

Kato Clinic of Internal Medicine ( Site 3509), Katsushika-ku, Tokyo

Kanno Naika ( Site 3511), Mitaka, Tokyo

Sugawara Clinic ( Site 3519), Nerima-ku, Tokyo

Shin Clinic ( Site 3517), Ota-ku, Tokyo

Medical Corporation Heishinkai ToCROM Clinic ( Site 3502), Shinjuku-ku, Tokyo

Medical Corporation Hakuaikai Wellness Tenjin Clinic ( Site 3520), Fukuoka, Not set

Hiroshima City Hiroshima Citizens Hospital ( Site 3518), Hiroshima, Not set

Mishuku Hospital ( Site 3524), Tokyo, Not set

Mitsukoshi Health and Welfare Foundation ( Site 3521), Tokyo, Not set

Chungbuk National University Hospital ( Site 3011), Cheongju-si, Chungbuk

Wonju Severance Christian Hospital ( Site 3008), Wonju, Kang-won-do

Chonnam National University Hospital ( Site 3014), Gwangju-si, Kwangju-Kwangyokshi

Seoul National University Bundang Hospital ( Site 3005), Seongnam, Kyonggi-do

Ajou University Hospital ( Site 3006), Suwon, Kyonggi-do

Dong-A University Hospital-Cardiology ( Site 3013), Busan, Pusan-Kwangyokshi

Pusan National University Hospital-Internal Medicine ( Site 3012), Busan, Pusan-Kwangyokshi

Inje University Haeundae Paik Hospital ( Site 3010), Haeundae-gu, Pusan-Kwangyokshi

Keimyung University Dongsan Hospital CRC room 1 ( Site 3003), Daegu, Taegu-Kwangyokshi

Seoul National University Hospital ( Site 3001), Seoul, Not set

Kangbuk Samsung Hospital ( Site 3009), Seoul, Not set

Severance Hospital, Yonsei University Health System ( Site 3002), Seoul, Not set

Asan Medical Center ( Site 3004), Seoul, Not set

Samsung Medical Center-cardiology ( Site 3000), Seoul, Not set

The Catholic Univ. of Korea Seoul St. Mary's Hospital-cardiology ( Site 3007), Seoul, Not set

Instituto Nacional de Ciencias Medicas y Nutricion Salvador -Unidad de Investigación de Enfermedade ( Site 1071), Mexico City, Distrito Federal

Instituto Jalisciense de Investigacion en Diabetes y Obesidad-Endocrinology ( Site 1057), Guadalajara, Jalisco

Radboudumc-internal medicine ( Site 1952), Nijmegen, Gelderland

Amsterdam UMC, locatie AMC-Vascular Medicine Clin Trial Unit ( Site 1954), Amsterdam, Noord-Holland

Dijklander Ziekenhuis ( Site 1953), Hoorn, Noord-Holland

Universitair Medisch Centrum Utrecht-Vascular Medicine Research ( Site 1955), Utrecht, Not set

Pacific Clinical Research Network - Rotorua ( Site 2902), Rotorua, Bay Of Plenty

New Zealand Clinical Research (Christchurch) ( Site 2901), Christchurch, Canterbury

Nordlandssykehuset ( Site 2041), Bodø, Nordland

Oslo Universitetssykehus Aker-Lipidklinikken ( Site 2040), Oslo, Not set

Changi General Hospital ( Site 3211), Singapore, Central Singapore

IATROS International ( Site 2204), Bloemfontein, Free State

Charlotte Maxeke Johannesburg Academic Hospital ( Site 2202), Johannesburg, Gauteng

Soweto Clinical Trials Centre ( Site 2203), Soweto, Gauteng

TREAD Research ( Site 2201), Cape Town, Western Cape

Tiervlei Trial Centre ( Site 2205), Cape Town, Western Cape

University of Cape Town (UCT)-Medicine, Division of Lipidology ( Site 2200), Cape Town, Western Cape

Hospital Universitario Virgen de la Victoria-UGC Endocrinologia y nutricion ( Site 2358), Malaga, Andalucia

EBA CENTELLES ( Site 2319), Centelles, Barcelona

Hospital Universitari Vall d'Hebron ( Site 2362), Barcelona, Cataluna

Hospital de Figueres ( Site 2361), Figueres, Gerona

Hospital Abente y Lago ( Site 2356), A Coruña, La Coruna

Hospital San Rafael de Coruna ( Site 2363), A Coruña, La Coruna

CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 2320), Santiago de compostela, La Coruna

Hospital Universitario Fundacion ALcorcon-Endocrinologia y Nutrición ( Site 2316), Alcorcón, Madrid, Comunidad De

HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 2344), Pozuelo de Alarcon, Madrid

Vithas Hospital Sevilla-Unidad de Salud Metabólica. Diabetes y Obesidad ( Site 2349), Castilleja de la Cuesta, Sevilla

Hospital Universitari Sant Joan de Reus ( Site 2329), Reus, Tarragona

HOSPITAL CLINICO DE VALENCIA-CARDIOLOGY ( Site 2321), Valencia, Valenciana, Comunitat

EAP Sardenya ( Site 2357), Barcelona, Not set

Hospital Universitario 12 de Octubre-Internal Medicine. Unidad de Ensayos Clínicos ( Site 2311), Madrid, Not set

Hospital Universitario Virgen Macarena-Cardiology ( Site 2352), Sevilla, Not set

Mackay Memorial Hospital -Tamsui Branch ( Site 3109), New Taipei City, New Taipei

Chi Mei Medical Center ( Site 3104), Tainan City, Tainan

Shin Kong Wu Ho-Su Memorial Hospital ( Site 3110), Taipei City, Taipei

Changhua Christian Hospital ( Site 3101), Changhua, Not set

Chang Gung Memorial Hospital at Kaohsiung ( Site 3102), Kaohsiung, Not set

National Cheng Kung University Hospital-Internal Medicine ( Site 3107), Tainan, Not set

National Taiwan University Hospital ( Site 3100), Taipei, Not set

Taipei Medical University Hospital ( Site 3108), Taipei, Not set

Taipei Veterans General Hospital ( Site 3106), Taipei, Not set

Chang Gung Medical Foundation-Linkou Branch ( Site 3105), Taoyuan, Not set

Ege Universitesi Hastanesi-Cardilogy Department ( Site 2502), Bornova, Izmir

Hacettepe Universite Hastaneleri ( Site 2500), Ankara, Not set

Ankara Bilkent Şehir Hastanesi-cardiology ( Site 2501), Ankara, Not set

Eskisehir Osmangazi University-Cardiology ( Site 2510), Eskisehir, Not set

Erciyes Universitesi Tıp Fakultesi Hastaneleri ( Site 2522), Kayseri, Not set

Kocaeli Üniversitesi-Cardiology ( Site 2516), Kocaeli, Not set

Barts Health NHS Trust-William Harvey Clinical Research Centre ( Site 4001), London, England

Royal Free Hospital ( Site 4000), London, England

Conditions: Hypercholesterolemia

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Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

NCT06498960

Recruiting

Prospective, multi-center, randomized, controlled trial of the eShunt System in the treatment of patients with normal pressure hydrocephalus.

Gender:

ALL

Ages:

60 years and above

Trial Updated:

07/09/2025

Locations: University of Southern California, Los Angeles, California +25 locations

University of Southern California, Los Angeles, California

Yale University, New Haven, Connecticut

Baptist Medical Center - Jacksonville, Jacksonville, Florida

University of South Florida, Tampa, Florida

Northwestern University, Chicago, Illinois

Advocate Lutheran General Hospital, Park Ridge, Illinois

Indiana University, Indianapolis, Indiana

University of Kansas Medical Center, Kansas City, Kansas

University of Kentucky Research Foundation, Lexington, Kentucky

Massachusetts General Hospital, Boston, Massachusetts

Brigham and Women's Hospital, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Boston, Massachusetts

Henry Ford Health, West Bloomfield, Michigan

Cooper Neurological Institute, Camden, New Jersey

Albany Medical Center, Albany, New York

Montefiore Medical Center, Bronx, New York

University at Buffalo Neurosurgery, Buffalo, New York

Northwell Health, Manhasset, New York

NYU Langone Health, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Lenox Hill Hospital, New York, New York

University of Rochester Medical Center, Rochester, New York

Cleveland Clinic, Cleveland, Ohio

Virginia Commonwealth University, Richmond, Virginia

Clinica La Sagrada Familia, Buenos Aires, Not set

St. Michael's Hospital, Toronto, Ontario

Conditions: Normal Pressure Hydrocephalus

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Testicular Evaluation of Azoospermia Using Micro-Ultrasound

NCT06941922

Recruiting

The investigation is a small feasibility study to determine whether there are imaging features related to the seminiferous tubules in the testes under microultrasound. The results from this study will provide guidance on the design and power analysis of future studies in this area.

Gender:

MALE

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Shady Grove Fertility, Rockville, Maryland +1 locations

Conditions: Azoospermia

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Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

NCT05422222

Recruiting

The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at least 1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

Gender:

ALL

Ages:

Between 1 year and 11 years

Trial Updated:

07/09/2025

Locations: Children's Hospital of Orange County, Orange, California +37 locations

Children's Hospital of Orange County, Orange, California

Stanford University Clinical and Translational Research Unit, Palo Alto, California

Children's Hospital of Colorado, Aurora, Colorado

The Emory Clinic / Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana

Boston Children's Hospital, Boston, Massachusetts

Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota

The Children's Mercy Hospital, Kansas City, Missouri

Washington University School of Medicine / St. Louis Children's Hospital, Saint Louis, Missouri

Cohen Children's Medical Center, Lake Success, New York

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Oregon Health & Science University, Portland, Oregon

UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Texas Children's Hospital - Wallace Tower, Houston, Texas

Vermont Lung Center, Colchester, Vermont

American Family Childrens Hospital, Madison, Wisconsin

The Kids Research Institute Australia, Nedlands, Not set

Women's and Children's Hospital, North Adelaide, Not set

The Royal Children's Hospital, Parkville, Not set

Queensland Children's Hospital, South Brisbane, Not set

The Hospital for Sick Children, Toronto, Not set

British Columbia Children's Hospital, Vancouver, Not set

CHU Lyon - Hopital Femme Mere-Enfant, Bron Cedex, Not set

Hopital Necker, Enfants Malades, Paris Cedex 15, Not set

Charité Universitätsmedizin BerlinX, Berlin, Not set

Kinderklinik III, Abt. fur Pneumologie, Essen, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Erasmus Medical Center / Sophia Children's Hospital, Rotterdam, Not set

Starship Children's Hospital, Grafton, Not set

Sahlgrenska Universitetssjukhuset, Göteborg, Not set

Karolinska Universitetssjukhuset, Huddinge, Stockholm, Not set

Inselspital - Universitaetsspital Bern, Bern, Not set

Kinderspital Zurich, Zurich, Not set

Children and Young Adults Research Unit, Cardiff, Not set

Great Ormond Street Hospital for Children, London, Not set

Conditions: Cystic Fibrosis

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