Clinical Trials & Research Studies in Canada(Updated 8/25)

Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II

NCT06467084

Recruiting

KVD900-303 is an open-label, multicenter clinical trial in patients aged 2 to 11 years old with HAE Type I or II.

Gender:

ALL

Ages:

Between 2 years and 11 years

Trial Updated:

07/09/2025

Locations: KalVista Investigative Site, Birmingham, Alabama +23 locations

Conditions: Hereditary Angioedema

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Testicular Evaluation of Azoospermia Using Micro-Ultrasound

NCT06941922

Recruiting

The investigation is a small feasibility study to determine whether there are imaging features related to the seminiferous tubules in the testes under microultrasound. The results from this study will provide guidance on the design and power analysis of future studies in this area.

Gender:

MALE

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Shady Grove Fertility, Rockville, Maryland +1 locations

Conditions: Azoospermia

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Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

NCT05422222

Recruiting

The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at least 1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

Gender:

ALL

Ages:

Between 1 year and 11 years

Trial Updated:

07/09/2025

Locations: Children's Hospital of Orange County, Orange, California +37 locations

Children's Hospital of Orange County, Orange, California

Stanford University Clinical and Translational Research Unit, Palo Alto, California

Children's Hospital of Colorado, Aurora, Colorado

The Emory Clinic / Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana

Boston Children's Hospital, Boston, Massachusetts

Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota

The Children's Mercy Hospital, Kansas City, Missouri

Washington University School of Medicine / St. Louis Children's Hospital, Saint Louis, Missouri

Cohen Children's Medical Center, Lake Success, New York

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Oregon Health & Science University, Portland, Oregon

UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Texas Children's Hospital - Wallace Tower, Houston, Texas

Vermont Lung Center, Colchester, Vermont

American Family Childrens Hospital, Madison, Wisconsin

The Kids Research Institute Australia, Nedlands, Not set

Women's and Children's Hospital, North Adelaide, Not set

The Royal Children's Hospital, Parkville, Not set

Queensland Children's Hospital, South Brisbane, Not set

The Hospital for Sick Children, Toronto, Not set

British Columbia Children's Hospital, Vancouver, Not set

CHU Lyon - Hopital Femme Mere-Enfant, Bron Cedex, Not set

Hopital Necker, Enfants Malades, Paris Cedex 15, Not set

Charité Universitätsmedizin BerlinX, Berlin, Not set

Kinderklinik III, Abt. fur Pneumologie, Essen, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Erasmus Medical Center / Sophia Children's Hospital, Rotterdam, Not set

Starship Children's Hospital, Grafton, Not set

Sahlgrenska Universitetssjukhuset, Göteborg, Not set

Karolinska Universitetssjukhuset, Huddinge, Stockholm, Not set

Inselspital - Universitaetsspital Bern, Bern, Not set

Kinderspital Zurich, Zurich, Not set

Children and Young Adults Research Unit, Cardiff, Not set

Great Ormond Street Hospital for Children, London, Not set

Conditions: Cystic Fibrosis

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Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy

NCT03394365

Recruiting

The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting of (1) solid organ transplant (SOT) after failure of rituximab (SOT-R) and rituximab plus chemotherapy (SOT-R+C) or (2) allogeneic hematopoietic cell transplant (HCT) after failure of rituximab.

Gender:

ALL

Ages:

All

Trial Updated:

07/09/2025

Locations: City of Hope (Adults and Pediatrics), Duarte, California +70 locations

City of Hope (Adults and Pediatrics), Duarte, California

University of California San Diego Moores Cancer Center (Adults only), La Jolla, California

Loma Linda University Medical Center (Adults only), Loma Linda, California

Children's Hospital Los Angeles, Div. of Research Immunology/BMT (Adults and Pediatrics), Los Angeles, California

UCLA Medical Center (Adults and Pediatrics), Los Angeles, California

University of California Davis Comprehensive Cancer Center (Adults only), Sacramento, California

Yale University (Adults and Pediatrics), New Haven, Connecticut

MedStar Georgetown University Hospital (Adults and Pediatrics), Washington, District of Columbia

University of Florida (Adults and Pediatrics), Gainesville, Florida

University of Miami/Jackson Memorial Hospital (Adults only), Miami, Florida

Winship Cancer Institute (Adults only), Atlanta, Georgia

Arthur M. Blank Hospital (Pediatrics), Atlanta, Georgia

Ann & Robert H. Lurie Children's Hospital of Chicago (Adults and Pediatrics), Chicago, Illinois

University of Chicago Medical Center - Duchossois Center for Advanced Medicine (Adults only), Chicago, Illinois

Loyola University Medical Center (Adults and Pediatrics), Maywood, Illinois

University of Maryland School of Medicine (Adults only), Baltimore, Maryland

Dana Farber Cancer Institute, Brigham and Women's Hospital (Adults and Pediatrics), Boston, Massachusetts

Washington University School of Medicine (Adults only), Saint Louis, Missouri

Montefiore Medical Center (Adults only), Bronx, New York

Montefiore Medical Center (Pediatrics only), Bronx, New York

Weill Cornell Medicine (Adults only), New York, New York

Columbia University Medical Center (Adults and Pediatrics), New York, New York

Memorial Sloan Kettering Cancer Center (Adults and Pediatrics), New York, New York

University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center (Adults and Pediatrics), Chapel Hill, North Carolina

Carolinas Medical Center/Levine Children's Hospital (Adults and Pediatrics), Charlotte, North Carolina

Duke Cancer Institute (Adults only), Durham, North Carolina

Cleveland Clinic Foundation (Adults and Pediatrics), Cleveland, Ohio

Nationwide Children's Hospital (Pediatrics only), Columbus, Ohio

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (Adults and Pediatrics), Columbus, Ohio

Oregon Health and Science University Physicians Pavilion (Adults and Pediatrics), Portland, Oregon

Hospital of the University of Pennsylvania (Adults only), Philadelphia, Pennsylvania

The Children's Hospital of Philadelphia Oncology Division, Blood & Marrow Transplant Section (Pediatrics), Philadelphia, Pennsylvania

University of Pittsburgh Medical Center (Adults only), Pittsburgh, Pennsylvania

Medical University of South Carolina (Adults and Pediatrics), Charleston, South Carolina

Saint Jude Children's Research Hospital (Pediatrics only), Memphis, Tennessee

Vanderbilt University Medical Center Henry-Joyce Cancer Clinic (Adults and Pediatrics), Nashville, Tennessee

Baylor Scott and White Research Institute (Adults only), Dallas, Texas

University of Texas Southwestern Medical Center - Children's Medical Center (Pediatrics only), Dallas, Texas

MD Anderson Cancer Center (Pediatrics and Adult), Houston, Texas

Froedtert and Medical College of Wisconsin - Clinical Cancer Center (Adults only), Milwaukee, Wisconsin

The Children's Hospital at Westmead (Pediatrics only), Westmead, New South Wales

Westmead Hospital (Adults only), Westmead, New South Wales

The Prince Charles Hospital (Adults only), Chermside, Queensland

Royal Adelaide Hospital (Adults only), Adelaide, South Australia

The Royal Children's Hospital Melbourne (Pediatrics only), Melbourne, Victoria

Fiona Stanley Hospital (Adults only), Murdoch, Western Australia

Medizinische Universitat Wien (Adults only), Wien, Not set

Centre Hospitalier Universitaire de Liège Site Sart Tilman (Adults and Pediatrics), Liège, Brussels

Universitair Ziekenhuis Leuven (Adults and Pediatrics), Leuven, Flemish Brabant

Alberta Children's Hospital (Adults and Pediatrics), Calgary, Alberta

Sick Kids (Pediatrics only), Toronto, Ontario

Princess Margaret Cancer Centre (Adults only), Toronto, Ontario

Centre Hospitalier Universitaire de Bordeaux (Adults only), Pessac, Aquitaine

Hôpital Saint Antoine (Adults only), Paris, Ile-de-France

Centre Hospitalier Régional Universitaire de Lille (Adults and Pediatrics), Lille cedex, Nord-Pas-de-Calais

Hôpital Necker-Enfants Malades (Pediatrics only), Paris 15, Île-de-France

Hôpital Universitaire Pitié Salpêtrière (Adults only), Paris Cedex 13, Île-de-France

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (Adults only), Milano, Not set

Fondazione IRCCS Policlinico San Matteo (Adults and Pediatrics), Pavia, Not set

Fondazione Policlinico Universitario Agostino Gemelli (Adults only), Roma, Not set

Ospedale Pediatrico Bambino Gesu (Pediatrics only), Roma, Not set

Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino (Adults only), Torino, Not set

Hospital Duran i Reynals (Adults and Pediatrics), Badalona, Barcelona

Hospital Universitario Marqués de Valdecilla (Adults and Pediatrics), Santander, Cantabria

Hospital Universitari Vall d'Hebrón - Institut de Recerca (Adults and Pediatrics), Barcelona, Not set

Hospital General Universitario Gregorio Marañón (Adults and Pediatrics), Madrid, Not set

University Hospital Virgen del Rocio (Adults and Pediatrics), Sevilla, Not set

Hospital Universitario La Fe (Adults and Pediatrics), Valencia, Not set

University Hospitals Birmingham NHS Foundation Trust (Adults only), Birmingham, England

King's College Hospital NHS Foundation Trust (Adults only), London, England

Imperial College Healthcare NHS Trust (Adults only), London, England

Conditions: Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications

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Tucatinib With Brain and/or Spinal XRT in Patients With HER2+ Metastatic Breast Cancer and LMD

NCT06016387

Recruiting

The proposed study will evaluate the safety and efficacy of XRT followed by systemic therapy among patients with HER2+ metastatic breast cancer and LMD

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: The Ottawa Hospital, Ottawa, Ontario +1 locations

Conditions: HER2-positive Breast Cancer, LMD

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Study to Assess Function and Satisfaction of Oral Ubrogepant in Adult Participants After Multiple Migraine Attacks In Canada

NCT06692881

Recruiting

Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will evaluate function and satisfaction with oral ubrogepant in treating adult participants after multiple migraine attacks. Ubrogepant is a drug approved for the acute treatment of migraine in adults. Approximately 167 participants will be enrolled in approximately 10-15 sites across Canada. Participants will receive ubrogepant as... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Calgary Headache Assessment and Management Program /ID# 271475, Calgary, Alberta +9 locations

Conditions: Migraine

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Cannabidiol Medication Intervention Trial

NCT06014424

Recruiting

CALM-IT is a Randomized, double-blind, placebo-controlled cross-over clinical trial. Safety and efficacy of cannabidiol (CBD) capsules assessed for managing agitation in patients with AD and to identify novel biomarkers of agitation severity and treatment response.

Gender:

ALL

Ages:

55 years and above

Trial Updated:

07/09/2025

Locations: University of Calgary, Calgary, Alberta +4 locations

Conditions: Alzheimer Disease

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Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy

NCT06174220

Recruiting

The TaRGET study is a multi-centre, prospective, randomized, double-blind, placebo-controlled trial designed to evaluate the potential therapeutic efficacy of tideglusib, a glycogen synthase kinase-3 β inhibitor, in genotype positive arrhythmogenic cardiomyopathy.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: Foothills Medical Centre, Calgary, Alberta +16 locations

Conditions: Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy

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Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer

NCT05314400

Recruiting

After a patient is diagnosed with colon cancer, they receive a CT of the chest, abdomen, and pelvis to see if the cancer has spread (metastasized) to other parts of the body. A common site for the cancer to spread to is the liver. If an abnormality is seen in the liver on CT, sometimes an MRI of the liver is required to determine a) whether it is cancer or not and b) whether there are small tumours in the liver that were not visible on CT. During the MRI, the patient is injected with intravenou... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/08/2025

Locations: St. Joseph's Healthcare, London, Ontario +1 locations

Conditions: Liver Metastasis Colon Cancer

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Evaluating the Effectiveness of the Nurse Ned Clinic

NCT05033301

Recruiting

The purpose of this non-randomized control trial is to evaluate the effectiveness of a virtual nurse-led survivorship clinic for prostate cancer (PCa) survivors. Through this trial, investigators will compare pre-determined survivorship outcomes of men receiving care via traditional specialist-led PCa virtual care model (Specialist Ned) to those receiving care via the newly-proposed nurse-led PCa virtual care model (Nurse Ned). In total, it is anticipated that a maximum of 600 men (300 in contro... Read More

Gender:

MALE

Ages:

18 years and above

Trial Updated:

07/08/2025

Locations: University Health Network (Princess Margaret Hospital), Toronto, Ontario

Conditions: Prostate Cancer

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Mirikizumab Real World Protocol

NCT06696014

Recruiting

The goal of this observational study is to learn about how effective mirikizumab (Omvoh) is when treating patients with ulcerative colitis (UC) Does mirikizumab (Omvoh) lead to a reduction in symptoms at intervals throughout one year? Participants being prescribed mirikizumab (Omvoh) as part of their regular medical care for UC will answer online survey questions about their bowel habits for 1 year.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/08/2025

Locations: South Denver Gastroenterology, Denver, Colorado +8 locations

Conditions: Ulcerative Colitis

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

NCT04363684

Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/08/2025

Locations: University of Alabama Birmingham, Birmingham, Alabama +26 locations

University of Alabama Birmingham, Birmingham, Alabama

University of California, Los Angeles, Los Angeles, California

University of California, San Diego, San Diego, California

University of California San Francisco, San Francisco, California

University of Colorado Denver, Denver, Colorado

Mayo Clinic Florida, Jacksonville, Florida

Emory University, Atlanta, Georgia

Northwestern University, Chicago, Illinois

Indiana University, Indianapolis, Indiana

Johns Hopkins University, Baltimore, Maryland

NIH, Bethesda, Maryland

Massachusetts General Hospital, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Mayo Clinic Rochester, Rochester, Minnesota

Washinton University in St. Louis, Saint Louis, Missouri

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada

Mount Sinai, New York, New York

Columbia University, New York, New York

University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

Case Western Reserve Medical Center, Cleveland, Ohio

University of Pennsylvania, Philadelphia, Pennsylvania

Vanderbilt University, Nashville, Tennessee

Nantz National Alzheimer Center Houston, Houston, Texas

UT San Antonio Health Science Center, San Antonio, Texas

University of Washington, Seattle, Washington

University of British Columbia, Vancouver, British Columbia

University of Toronto, Toronto, Ontario

Conditions: Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Behavioral Variant Frontotemporal Dementia (bvFTD), Semantic Variant Primary Progressive Aphasia (svPPA), Nonfluent Variant Primary Progressive Aphasia (nfvPPA), FTD With Amyotrophic Lateral Sclerosis (FTD/ALS), Amyotrophic Lateral Sclerosis, Oligosymptomatic PSP (oPSP), C9orf72, GRN Related Frontotemporal Dementia, MAPT Gene Mutation, TBK1 Gene Mutation, Oligosymptomatic Progressive Supranuclear Palsy

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All Clinical Trials in Canada

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