All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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TSC Biosample Repository and Natural History Database

NCT05676099

Recruiting

The TSC Biosample Repository collects and stores samples of blood, DNA, and tissues that scientists can request to use in their research. The samples we collect are all linked to clinical data in the TSC Natural History Database. The TSC Natural History Database captures clinical data to document the impact of the disease on a person's health over his or her lifetime. This data may be collected retrospectively or prospectively.

Gender:

ALL

Ages:

All

Trial Updated:

07/07/2025

Locations: University of Alabama Birmingham, Birmingham, Alabama +23 locations

University of Alabama Birmingham, Birmingham, Alabama

Loma Linda University Children's Hospital, Loma Linda, California

University of California Los Angeles, Los Angeles, California

Jack & Julia Center for TSC, Oakland Children's Hospital and Research Center, Oakland, California

The Children's Hospital, Denver, Colorado

Nicklaus Children's Hospital, Miami, Florida

Chicago Comer Children's Hospital Neurogenetic Clinic, University of Chicago, Chicago, Illinois

University of Iowa Hospitals and Clinics, Iowa City, Iowa

TSC Alliance, Silver Spring, Maryland

Boston Children's Hospital, Boston, Massachusetts

Massachusetts General Hospital, Boston, Massachusetts

Minnesota Epilepsy Group, Roseville, Minnesota

Washington University in St. Louis, Saint Louis, Missouri

New York University Medical Center, New York, New York

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

University of Pennsylvania Medical Center, Philadelphia, Pennsylvania

Le Bonheur Children's Hospital, Memphis, Tennessee

Scottish Rite Hospital for Children, Dallas, Texas

Texas Childrens Hospital Baylor College of Medicine, Houston, Texas

Memorial Hermann-Texas Medical Center (University of Texas Houston), Houston, Texas

Children's National Medical Center, Fairfax, Virginia

Centre Hospitalier de L'Université de Montréal (Chum), Montréal, Not set

Sainte-Justine Université de Montréal, Montréal, Not set

Conditions: Tuberous Sclerosis, Lymphangioleiomyomatosis

Learn More ›

Cognitive Health Awareness Program in Surgical Patients

NCT06540638

Recruiting

Addressing brain health and cognitive impairment (CI) in the aging population is important, especially in those undergoing surgery. While certain adverse outcomes are beyond control due to various factors, some may be preventable, such as delirium. It is crucial for patients and their families to be fully aware of the heightened risks associated with CI. By discussing the implications for individuals and their families, patients can make informed decisions about their health. Additionally, patie... Read More

Gender:

ALL

Ages:

60 years and above

Trial Updated:

07/07/2025

Locations: 399 Bathurst St. Toronto Western Hospital, Preadmission Clinic, Dept. of Anesthesia, Toronto, Ontario +1 locations

Conditions: Dementia, Cognitive

Learn More ›

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

NCT05509777

Recruiting

Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention. The purpose of the mirikizumab study is to evaluate efficacy, safety, tolerability, and how well mirikizumab absorbs into the body of pediatric participants with Crohn's disease. Study periods for the intervention-specific appendix (ISA) will be as follows: * A 12-week induction period * A maintenance period from Week 12 to Week 52, and * A safety follow-up period... Read More

Gender:

ALL

Ages:

Between 2 years and 17 years

Trial Updated:

07/07/2025

Locations: University of California San Diego, La Jolla, California +82 locations

University of California San Diego, La Jolla, California

Cedars Sinai Medical Center, Los Angeles, California

Connecticut Children's Medical Center, Hartford, Connecticut

Emory University, Atlanta, Georgia

Children's Center for Digestive Health Care, LLC, Atlanta, Georgia

Riley Childrens Hospital, Indianapolis, Indiana

Boston Children's Hospital, Boston, Massachusetts

Atlantic Children's Health--Pediatric Gastroenterology, Morristown, New Jersey

Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC), New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Medical Center/New York Presbyterian, New York, New York

Childrens Medical Center, Dayton, Ohio

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Cook Children's Medical Center, Fort Worth, Texas

University of Vermont Medical Center, Burlington, Vermont

Seattle Children's Hospital, Seattle, Washington

AKH - Medizinische Universtität Wien, Vienna, Not set

Cliniques universitaires Saint-Luc, Bruxelles, Brussel

UZ Leuven, Leuven, Vlaams-Brabant

Universitair Ziekenhuis Brussel, Brussel, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Integral Pesquisa e Ensino, Votuporanga, Sao Paulo

Hospital PUC-CAMPINAS, Campinas, São Paulo

Hospital Pequeno Príncipe, Curitiba-PR, Not set

Hospital das Clínicas - UFG (Universidade Federal de Goiás), Goiânia, Not set

Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set

NDI - Nucleo de Doenças Infecciosas, Santos Dumont, Not set

Children's & Women's Health Centre of British Columbia, Vancouver, British Columbia

IWK Health Centre, Halifax, Nova Scotia

London Health Sciences Centre (LHSC) - Victoria Hospital, London, Ontario

The Hospital for Sick Children, Toronto, Ontario

Hopital Jeanne de Flandre - CHRU Lille, Lille Cedex, Nord

CHU AMIENS Picardie Site SUD CRC, Amiens, Not set

URC CIC, Paris, Not set

Hôpital Robert Debré - Paris, Paris, Not set

Kaplan Medical Center, Pediatric Gastroenterology Dept., Rehovot, Central Dsitrict Of Israel

Soroka Medical Center, Beer Sheva, Not set

Shamir Medical Center (Assaf Harofeh), Israel, Not set

Shaare Zedek, Jerusalem, Not set

Hadassah University Hospital, Ein Kerem,, Jerusalem, Not set

Schneider Children's Medical Center, Petah Tiqva, Not set

Asst Papa Giovanni Xxiii Bergamo, Bergamo, Not set

Azienda USL di Bologna, Bologna, Not set

SOC Gastroenterologia e Nutrizione - AOU Meyer (Primo Piano Ala OVEST, accettazione DH centralizzato), Firenze, Not set

Ospedale dei Bambini Vittore Buzzi, Milano, Not set

Ospedale Pediatrico Bambino Gesù, Roma, Not set

Gastroenterologia ed epatologia pediatrica (Piano terra della Clinica Pediatrica), Roma, Not set

Hirosaki University Hospital, Hirosaki, Aomori Pref.

Kokikai Tsujinaka Hospital Kashiwanoha, Kashiwa-shi, Chiba-Ken

Kobe University Hospital, Kobe, Hyogo

Yokohama City University Medical Center, Center of IBD, Yokohama-shi, Kanagawa-Ken

Miyagi Children's Hospital, Sendai-shi, Miyagi

Juntendo University Hospital, Bunkyo-ku, Tokyo

National Center for Child Health and Development, Setagaya-ku, Tokyo

Saga University Hospital, Saga, Not set

Kyungpook National University Chilgok Hospital, Daegu, Gyeongsangbuk-do

Samsung Medical Center, Seoul, Korea

Inje University Haeundae Paik Hospital, Busan, Kwangyǒkshi

Seoul National University Hospital, Seoul, Teukbyeolsi [Seoul]

Severance Hospital, Yonsei University Health System, Seoul, Not set

Erasmus Medisch Centrum, Rotterdam, Zuid-Holland

Akershus Universitetssykehus, Nordbyagen, Not set

Oslo University Hospital, Oslo, Not set

Universitetssykehuset Nord-Norge, Tromsø, Not set

St-Olavs Hospital, Trondheim, Not set

Instytut Pomnik-Centrum Zdrowia Dziecka, Warszawa, Masovian

Uniwersytecki Szpital Dziecięcy w Krakowie, Krakow, Not set

Korczowski Bartosz, Gabinet Lekarski, Rzeszow, Not set

Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga), Braga, Not set

Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisboa, Not set

Centro Hospitalar de São João, E.P.E., Porto, Not set

Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona

Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona

Hospital Universitario Reina Sofia, Cordoba, Not set

Hospital Universitari i Politecnic La Fe, València, Not set

Royal London Hospital, Whitechapel, Greater London

Great Ormond Street Hospital For Children NHS Foundation Trust, London, London, City Of

Royal Hospital for Children and Young People, Edinburgh, Lothian Region

Oxford University Hospitals NHS trust John Radcliffe hospital, Headington, Oxford

Sheffield Children's Hospital, Sheffield, South Yorkshire

Manchester University NHS Foundation Trust, Manchester, Not set

Conditions: Crohn's Disease

Learn More ›

Childhood Cancer Survivor Study

NCT01120353

Recruiting

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic mod... Read More

Gender:

ALL

Ages:

All

Trial Updated:

07/07/2025

Locations: University of Alabama at Birmingham/Children's of Alabama, Birmingham, Alabama +30 locations

University of Alabama at Birmingham/Children's of Alabama, Birmingham, Alabama

City of Hope National Medical Center, Duarte, California

Children's Hospital Los Angeles, Los Angeles, California

University of California-Los Angeles, Los Angeles, California

Children's Hospital of Orange County, Orange, California

University of California-San Francisco, San Francisco, California

Stanford University School of Medicine, Stanford, California

Children's Hospital Colorado, Aurora, Colorado

Children's National Medical Center, Washington, District of Columbia

Emory University/Children's Health Care of Atlanta, Atlanta, Georgia

Ana & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

University of Chicago, Chicago, Illinois

Indiana University/Riley Hospital for Children, Indianapolis, Indiana

Dana-Farber Cancer Institute, Boston, Massachusetts

University of Michigan/Mott Children's Hospital, Ann Arbor, Michigan

Children's Hospitals & Clinics of Minnesota, Minneapolis, Minnesota

University of Minnesota, Minneapolis, Minnesota

Mayo Clinic, Rochester, Minnesota

St. Louis Children's Hospital/The Washington University, Saint Louis, Missouri

Roswell Park Cancer Institute, Buffalo, New York

Memorial-Sloan Kettering Cancer Center, New York, New York

Nationwide Children's Hospital, Columbus, Ohio

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

St. Jude Children's Research Hospital, Memphis, Tennessee

University of Texas Southwestern Medical Center, Dallas, Texas

Cook Children's Medical Center, Fort Worth, Texas

M.D. Anderson Cancer Center, Houston, Texas

Texas Children's Hospital, Houston, Texas

Seattle Children's Hospital, Seattle, Washington

The Hospital for Sick Children, Toronto, Ontario

Conditions: Cancer

Learn More ›

A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B)

NCT06349473

Recruiting

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) of SR604 in healthy participants (Part A) and to evaluate the safety, tolerability, PK, PD, and efficacy of SR604 in participants with Hemophilia A or Hemophilia B, with or without inhibitors (Part B).

Gender:

MALE

Ages:

Between 18 years and 60 years

Trial Updated:

07/07/2025

Locations: California Clinical Trials Medical Group (CCTMG), Glendale, California +9 locations

Conditions: Healthy Participants, Hemophilia A, Hemophilia B

Learn More ›

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

NCT05727904

Recruiting

This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combination with pembrolizumab compared with pembrolizumab alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who subsequently have a blinded independent central review- verified confirmed progressive disease (PD) will be offered lifileucel monotherapy in an optional crossove... Read More

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

07/07/2025

Locations: University of Alabama at Birmingham: The Kirklin Clinic, Birmingham, Alabama +71 locations

University of Alabama at Birmingham: The Kirklin Clinic, Birmingham, Alabama

City of Hope, Duarte, California

USC Norris Comprehensive Cancer Center, Los Angeles, California

California Pacific Medical Center, San Francisco, California

University of Colorado Cancer Center, Aurora, Colorado

Orlando Health Cancer Institute, Orlando, Florida

University of Illinois Hospital & Health Sciences System, Chicago, Illinois

University of Kansas, Kansas City, Kansas

University of Louisville - James Graham Brown Cancer Center, Louisville, Kentucky

National Cancer Institute, Bethesda, Maryland

Barbara Ann Karmanos Cancer Hospital dba Karmanos Cancer Center, Detroit, Michigan

Henry Ford Health, Detroit, Michigan

Dartmouth-Hitchcock Medical Center (DHMC) - Norris Cotton Cancer Center, Lebanon, New Hampshire

MD Anderson Cancer Center at Cooper, Camden, New Jersey

Oncology Hematology Care, Cincinnati, Ohio

Ohio State University, Columbus, Ohio

St. Luke's Cancer Center - Anderson, Easton, Pennsylvania

Allegheny Health Network, Pittsburgh, Pennsylvania

Baptist Cancer Center, Bartlett, Tennessee

SCRI Oncology Partners, Nashville, Tennessee

Virginia Commonwealth University, Richmond, Virginia

Swedish Cancer Institute, Edmonds, Washington

Greenslopes Private Hospital, Greenslopes, Queensland

Peter MacCallum Cancer Centre, Melbourne, Victoria

Fiona Stanley Hospital, Murdoch, Western Australia

Flinders Medical Centre, Bedford Park, Not set

Westmead Hospital, Westmead, Not set

Universitair Ziekenhuis Brussel - Oncologisch Centrum, Jette, Not set

Centre hospitalier de l'Université de Montréal, Montréal, Quebec

Princess Margaret Cancer Centre, Toronto, Not set

Institut Paoli Calmettes, Marseille, Not set

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu, Nantes, Not set

Hopital Saint Louis, Paris, Not set

Universitätsklinikum Carl Gustav Carus, Dresden, Not set

Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set

Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck, Not set

Klinikum Rechts der Isar der Technischen Universität München, Munich, Not set

Hadassah Medical Center, Jerusalem, Not set

Sheba Medical Center, Ramat Gan, Not set

Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

Istituto Romagnolo per lo Studio dei Tumori, Meldola, Forlì-Cesena

Centro di Riferimento Oncologico IRCCS, Aviano, Friuli-Venezia Giulia

Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana

Istituto Europeo Di Oncologia, Milan, Not set

Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale, Napoli, Not set

Azienda Ospedaliera Universitaria Senese, Siena, Not set

Bundang Medical Center - CHA University, Seongnam-si, Gyeonggi-do

Seoul National University Hospital, Seoul, Not set

Severance Hospital, Yonsei University Health System, Seoul, Not set

Nederlands Kanker Instituut, Amsterdam, Not set

Hospital Universitario Marques de Valdecilla, Santander, Cantabria

Hospital Regional Universitario de Malaga - Hospital General, Malaga, Málaga

Instituto Oncologico Rosell, Barcelona, Not set

Hospital Universitari Vall dHebron, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

Hospital 12 de Octubre, Madrid, Not set

Hospital Universitario Madrid Sanchinarro - CIOCC, Madrid, Not set

Hospital Universitario Quirónsalud Madrid, Madrid, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

Clínica Universitaria de Navarra, Pamplona, Not set

Hospital Universitario Virgen Macarena, Sevilla, Not set

Consorcio Hospital General Universitario de Valencia, Valencia, Not set

Sahlgrenska Universitetssjukhuset, Göteborg, Vastra Gotalands Lan

Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Not set

Queen Elizabeth Hospital Birmingham, Birmingham, England

Freeman Hospital, Newcastle upon Tyne, England

Royal Marsden Hospital, Chelsea, London

Beaston West of Scotland Canter Centre, Glasgow, Not set

Guy's Hospital, London, Not set

Sarah Cannon Research Institute UK, London, Not set

Conditions: Metastatic Melanoma, Unresectable Melanoma, Melanoma

Learn More ›

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

NCT05651932

Recruiting

A Phase I study to evaluate the safety of a novel, orally available, selective, and potent small molecule inhibitor of the histone lysine methyl transferase MMSET (also known as NSD2/WHSC1) to prevent the dimethylation of H3K36 in adult patients with relapsed or refractory multiple myeloma (RRMM).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: UCSF Medical Center - Hematology and Blood and Marrow Transplant Clinic, San Francisco, California +20 locations

UCSF Medical Center - Hematology and Blood and Marrow Transplant Clinic, San Francisco, California

Mayo Clinic Hospital - Florida, Jacksonville, Florida

The Winship Cancer Institute of Emory University, Atlanta, Georgia

Massachusetts General Hospital, Boston, Massachusetts

Mayo Clinic - Transplant Center - Rochester, Rochester, Minnesota

Hackensack University Medical Center, Hackensack, New Jersey

Memorial Sloan-Kettering Cancer Center, New York, New York

Atrium Health, Levine Cancer Institute, Charlotte, North Carolina

Duke University Hospital, Durham, North Carolina

University of Pennsylvania, Philadelphia, Pennsylvania

Tennessee Oncology, Nashville, Tennessee

University of Texas Southwestern Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas

University Health Network (UHN) - Princess Margaret Cancer Centre (Princess Margaret Hospital), Toronto, Ontario

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu, Nantes, Not set

Centre Hospitalier Universitaire de Poitiers (CHU de Poitiers), Poitiers, Not set

Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, Not set

Universitaire de Lille, Villeneuve-d'Ascq, Not set

Clínica Universidad de Navarra, Pamplona, Navarra

Hospital ClÃ-nic de Barcelona, Barcelona, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Instituto de Investigacion Biomedica de Salamanca (IBSAL), Salamanca, Not set

Conditions: Multiple Myeloma, Myeloma, Myeloma Multiple

Learn More ›

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

NCT03093116

Recruiting

Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies harboring an ALK, ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. Midazolam DDI substudy will examine effect of of repotrectinib on CYP3A induction. Phase 2 will determine the confirmed Overall Response Rate (ORR) as assessed by Blin... Read More

Gender:

ALL

Ages:

12 years and above

Trial Updated:

07/07/2025

Locations: Local Institution - 2129, Duarte, California +164 locations

Local Institution - 2129, Duarte, California

Local Institution - 2120, Glendale, California

Local Institution - 2136, La Jolla, California

Local Institution - 2114, La Jolla, California

Local Institution - 2121, Long Beach, California

Local Institution - 2101, Orange, California

University of California Irvine Medical Center, Orange, California

Local Institution - 2126, Santa Rosa, California

Local Institution - 1003, Aurora, Colorado

Local Institution - 2103, Aurora, Colorado

Local Institution - 2106, Washington, District of Columbia

Local Institution - 2110, Washington, District of Columbia

Local Institution - 2128, Hollywood, Florida

Local Institution - 2113, Tampa, Florida

Local Institution - 2139, Athens, Georgia

Local Institution - 2134, Columbus, Georgia

Local Institution - 2125, Chicago, Illinois

Local Institution - 2142, Peoria, Illinois

Local Institution - 2116, New Orleans, Louisiana

Local Institution - 2133, Baltimore, Maryland

Local Institution - 2104, Boston, Massachusetts

Local Institution - 1004, Boston, Massachusetts

Local Institution - 2131, Boston, Massachusetts

Local Institution - 2105, Ann Arbor, Michigan

Local Institution - 2111, Detroit, Michigan

Local Institution - 2140, Detroit, Michigan

Local Institution - 2132, Saint Paul, Minnesota

Local Institution - 2147, Bolivar, Missouri

Local Institution - 2115, Saint Louis, Missouri

Local Institution - 2122, New Brunswick, New Jersey

Local Institution - 2117, New York, New York

Local Institution - 2102, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Local Institution - 2144, Goldsboro, North Carolina

Local Institution - 2112, Canton, Ohio

Local Institution - 2143, Cincinnati, Ohio

Local Institution - 2109, Cleveland, Ohio

Local Institution - 2123, Columbus, Ohio

Local Institution - 2119, Toledo, Ohio

Local Institution - 2108, Philadelphia, Pennsylvania

Local Institution - 2148, Memphis, Tennessee

Local Institution - 2130, Dallas, Texas

Local Institution - 2127, Houston, Texas

Local Institution - 2138, Houston, Texas

Local Institution - 2146, Kingwood, Texas

Local Institution - 2137, Fairfax, Virginia

Local Institution - 2107, Seattle, Washington

Local Institution - 2141, Tacoma, Washington

Local Institution - 2145, Appleton, Wisconsin

Local Institution - 6102, Camperdown, New South Wales

Local Institution - 6103, Adelaide, South Australia

Local Institution - 6101, Melbourne, Victoria

Local Institution - 3301, East Melbourne, Not set

Local Institution - 4802, Antwerp, Not set

Local Institution - 4801, Leuven, Not set

Local Institution - 2202, Edmonton, Alberta

Local Institution - 2205, Vancouver, British Columbia

Local Institution - 2201, Toronto, Ontario

Local Institution - 6503, Toronto, Ontario

Local Institution - 2203, Ontario, Not set

Local Institution - 2204, Ottawa, Not set

Local Institution - 6702, Beijing, Beijing

Beijing Cancer hospital, Beijing, Beijing

Daping Hospital, the Third Affiliated Hospital of Third Military Medical University /Cancer Center, Daping, Chongqing

Local Institution - 6719, Fuzhou, Fujian

The First Affiliated hospital of Xiamen University-oncology, Xiamen, Fujian

Guangdong Provincial People'S Hospital, Guangzhou, Guangdong

Local Institution - 6733, Guangzhou, Guangdong

Local Institution - 6505, Shenzhen, Guangdong

The Affiliated Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang

Local Institution - 6504, Shatin, Hong Kong

Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology/Cancer Center Department, Wuhan, Hubei

Local Institution - 6705, Changsha, Hunan

Hunan Cancer Hospital-thoracic oncology II, Changsha, Hunan

Local Institution - 6748, Nanjing, Jiangsu

XuZhou Central Hospital/Oncology Department, Xuzhou City, Jiangsu

Jilin Cancer Hospital/Medical Oncology Department, Changchun, Jilin

The first hospital of Jilin university-Oncology Department, Changchun, Jilin

Liaoning Cancer Hospital, Shenyang, Liaoning

Tangdu Hospital, Xi'an, Shan3xi

Shanxi Bethune Hospital, Taiyuan, Shanxi

Sichuan Cancer Hospital/Medical Oncology Department, Chengdu City, Sichuan

The First Hospital Affiliated To AMU - Southwest Hospital, Chongqing, Sichuan

Local Institution - 6725, Hangzhou, Zhejiang

Zhejiang Cancer Hospital-Oncology, Hangzhou, Zhejiang

The Third Xiangya Hospital of Central South University/Department of Respiratory and Critical Care Medicine, Changsha, Not set

West China Hospital Sichuan University/Lung cancer center, Chengdu, Not set

The First Affiliated Hospital - Zhejiang University School of Medicine, Hangzhou, Not set

Anhui Provincial Hospital, Hefei, Not set

Shanghai Chest Hospital, Shanghai, Not set

Weifang People's Hospital/Medical Oncology Department, Weifang City, Not set

Henan Cancer Hospital/The 1st pneumology department, Zhengzhou, Not set

Local Institution - 4901, Copenhagen, Not set

Local Institution - 4201, Marseille, Bouches-du-Rhône

Local Institution - 4207, Brest, Not set

Local Institution - 4204, Dijon Cedex, Not set

Local Institution - 4206, Grenoble Cedex 9, Not set

Centre Antoine-Lacassagne, Nice, Not set

Chu Poitiers, Poitiers, Not set

Local Institution - 4203, St Mande, Not set

Institute Gustave Roussy, Villejuif, Not set

Local Institution - 4704, Berlin, Not set

Local Institution - 4703, Dresden, Not set

Local Institution - 4702, Heidelberg, Not set

Local Institution - 4701, Koln, Not set

Local Institution - 6502, Hong Kong, Not set

Local Institution - 6501, Hong Kong, Not set

Local Institution - 5101, Budapest, Not set

Local Institution - 5103, Budapest, Not set

Local Institution - 4301, Milano, MI

Local Institution - 4306, Milano, Not set

Local Institution - 4307, Palermo, Not set

Local Institution - 4303, Pordenone, Not set

Local Institution - 4304, Ravenna, Not set

Local Institution - 4305, Reggio Emilia, Not set

Local Institution - 4308, Roma, Not set

Local Institution - 4302, Terni, Not set

Ehime University Hospital, Toon, Ehime

Hokkaido University Hospital, Sapporo-shi, Hokkaido

Kanagawa cancer center, Yokohama, Kanagawa

Osaka City General Hospital, Osaka-shi, Osaka

National Cancer Center Hospital., Chuo-ku, Tokyo

Tottori University Hospital, Yonago, Tottori

National Cancer Center Hospital East, Kashiwa, Not set

Nagoya University Hospital, Nagoya-shi, Not set

Osaka International Cancer institute, Osaka, Not set

Local Institution - 3003, Seoul, Gangnam-gu

Local Institution - 6308, Hwasun-eup, Hwasun-gun, Jeonnam

Yonsei University Health System, Seoul, Seodaemun-gu

Local Institution - 3002, Seoul, Seoul Teugbyeolsi

Local Institution - 6301, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 6303, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 6306, Cheongju-si, Not set

Seoul National University Hospital, Seoul, Not set

Local Institution - 6302, Seoul, Not set

Local Institution - 6307, Seoul, Not set

Local Institution - 6305, Seoul, Not set

Local Institution - 6304, Seoul, Not set

Local Institution - 4502, Amsterdam, Not set

Local Institution - 4501, Groningen, Not set

Ośrodek Badań Klinicznych Wczesnych Faz, Uniwersyteckie Centrum Kliniczne, Gdańsk, Not set

Local Institution - 4604, Lublin, Not set

Local Institution - 4605, Poznań, Not set

Local Institution - 4603, Szczecin, Not set

Local Institution - 4602, Warszawa, Not set

Local Institution - 6401, Singapore, Not set

Local Institution - 6402, Singapore, Not set

Local Institution - 4102, Barcelona, Not set

Local Institution - 4101, Barcelona, Not set

Local Institution - 4106, Madrid, Not set

Local Institution - 4104, Madrid, Not set

Local Institution - 4103, Madrid, Not set

Local Institution - 4105, Madrid, Not set

Clinica Universidad de Navarra, Pamplona, Not set

Instituto Valenciano de Oncología (IVO) - Unidad de Investigación Clínica FINCIVO, Valencia, Not set

Local Institution - 6201, Taiepi, Not set

Local Institution - 6203, Tainan, Not set

Local Institution - 6202, Taipei, Not set

Local Institution - 4401, London, Not set

Local Institution - 4402, London, Not set

Local Institution - 4404, London, Not set

Local Institution - 4403, Manchester, Not set

Local Institution - 4405, Sutton, Not set

Conditions: Locally Advanced Solid Tumors, Metastatic Solid Tumors

Learn More ›

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

NCT05592626

Recruiting

This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent administered intravenously in participants with advanced solid tumors that are antigen-rich.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: Loma Linda University Cancer Center, Loma Linda, California +31 locations

Loma Linda University Cancer Center, Loma Linda, California

UC Davis Comprehensive Cancer Center, Sacramento, California

Sarah Cannon Research Institute at HealthONE, Denver, Colorado

AdventHealth Celebration, Celebration, Florida

University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida

The University of Kansas Cancer Center, Kansas City, Kansas

National Institutes of Health, Bethesda, Maryland

Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

Karmanos Cancer Institute, Detroit, Michigan

Memorial Sloan-Kettering Cancer Center, New York, New York

The Ohio State University Comprehensive Cancer Center, Columbus, Ohio

University of Oklahoma Health Sciences, Stephenson Cancer Center, Oklahoma City, Oklahoma

Sarah Cannon Research Institute Oncology Partners (SCRI-Nashville), Nashville, Tennessee

The University of Texas, MD Anderson Cancer Center, Houston, Texas

UT Health Mays Cancer Center, San Antonio, Texas

Fred Hutchinson Cancer Center, Seattle, Washington

University of Wisconsin- Madison, Madison, Wisconsin

Princess Margaret Cancer Centre, Toronto, Ontario

Research Institute of McGill University Health Centre, Montreal, Quebec

Institut Bergonié, Bordeaux, Not set

Centre Leon Berard, Lyon, Not set

Hopsital Institut Curie, Paris, Not set

Oncopole Claudius Regaud IUCT, Toulouse, Not set

Institute Gustave Roussy, Villejuif, Not set

Vall d'Hebron Institute of Oncology, Barcelona, Cataluna

Clinica Universidad de Navarra, San Blas-Canillejas, Madrid

NEXT Oncology Barcelona, Hospital Quirónsalud Barcelona, Barcelona, Not set

START Madrid FJD, Madrid, Not set

Hospital Universitario Quirónsalud Madrid, Madrid, Not set

Clinica Universidad de Navarra, Pamplona, Not set

Instituto de Investigacion Sanitaria, INCLIVA, Valencia, Not set

Conditions: Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm, Neoplasms by Site, Papillomavirus Infection, Epstein-Barr Virus Infections, Carcinoma, Neoplasms, Vulvar Neoplasms, Vulvar Diseases, Abdominal Neoplasm

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A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

NCT05797610

Recruiting

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of sefaxersen (RO7434656), a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease despite optimized supportive care.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: UAB Nephrology Research Clinic, Birmingham, Alabama +182 locations

UAB Nephrology Research Clinic, Birmingham, Alabama

Sunrise Medical Management LLC, Surprise, Arizona

Tucson Neuroscience Research - M3 WR, Tucson, Arizona

Southern California Medical Research Center, La Palma, California

Academic Medical Research Institute - Los Angeles, Los Angeles, California

UCLA University of California Los Angeles, Los Angeles, California

North America Research Institute-San Dimas, San Dimas, California

Hope Clinic & Research Center, Hialeah, Florida

LCC Medical Research - Miami - ClinEdge - PPDS, Miami, Florida

L&C Professional Medical Research Institute, W. Miami, Florida

Cowry Medical Group LLC, Acworth, Georgia

Care Institute Idaho Kidney Institute, Chubbuck, Idaho

Care Institute Idaho Kidney Institute, Idaho Falls, Idaho

Nephrology Associates of Northern Illinois, Hinsdale, Illinois

University of Iowa, Iowa City, Iowa

Massachussets General Hospital, Boston, Massachusetts

University of Mississippi Medical Center, Jackson, Mississippi

Sierra Nevada Nephrology Consultants, Reno, Nevada

NYU Langone Nephrology Associates - Mineola, Mineola, New York

North Carolina Nephrology, PA, Raleigh, North Carolina

Ohio State University Wexner Medical Center - Outpatient Care East, Columbus, Ohio

Kidney and Hypertension Center, Roseburg, Oregon

Global Medical Research - M3 WR, Dallas, Texas

Texas Kidney Institute - Dallas, Dallas, Texas

Pioneer Research Solutions, Houston, Texas

Prolato Clinical Research Center, Houston, Texas

R & H Clinical Research, Katy, Texas

Revival Research Corporation - Sherman - ClinEdge - PPDS, Sherman, Texas

Utah Kidney Research Institute, Salt Lake City, Utah

Nephrology Associates of Northern Virginia Inc, Fairfax, Virginia

Virginia Commonwealth University, Richmond, Virginia

Milwaukee Nephrologists, Sc, Wauwatosa, Wisconsin

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada, Ciudad Autonoma Buenos Aires, Not set

Consultorios Médicos Dr. Doreski, Ciudad Autonoma Buenos Aires, Not set

Sanatorio Mayo Privado, Cordoba, Not set

Sanatorio Allende, Cordoba, Not set

Instituto Medico de la Fundacion Estudios Clinicos, Rosario, Not set

Nepean Hospital, Kingswood, New South Wales

St George Hospital, Kogarah, New South Wales

Liverpool Hospital, Liverpool, New South Wales

Princess Alexandra Hospital, Woolloongabba, Queensland

Royal Adelaide Hospital, Adelaide, South Australia

Royal Melbourne Hospital, Parkville, Victoria

Sunshine Hospital, St Albans, Victoria

Santa Casa de Misericordia de Belo Horizonte - PPDS, Belo Horizonte, Minas Gerais

Freire Pesquisa Clinica, Belo Horizonte, Minas Gerais

Hospital de Clinicas de Porto Alegre HCPA PPDS, Porto Alegre, Rio Grande Do Sul

Centro de Pesquisa Clinica da Fundação Pró Rim, Joinville, Santa Catarina

Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, São Paulo

Hospital Do Rim E Hipertensao Fundacao Oswaldo Ramos, Sao Paulo, São Paulo

Instituto D?Or Pesquisa e Ensino - Hospital Gloria D?Or, Rio de Janeiro, Not set

Vancouver General Hospital, Vancouver, British Columbia

Cape Breton Regional Hospital, Sydney, Nova Scotia

London Health Sciences Centre · Victoria Hospital, London, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

Montreal General Hospital, Montreal, Quebec

Centre Hospitalier Universitaire de Quebec, Quebec, Not set

Beijing Friendship Hospital, Capital Medical University - PPDS, Beijing, Beijing

Peking University First Hospital, Beijing City, Not set

Peking University People's Hospital, Beijing, Not set

Changzhou First People's Hospital, Changzhou, Not set

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu City, Not set

Guangdong Provincial People's Hospital, Guangzhou City, Not set

Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou City, Not set

Zhejiang Provincial People?s Hospital, Hangzhou, Not set

The Second Affiliated Hospital of Nanchang University, Nanchang City, Not set

The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Not set

Ningbo No.2 Hospital, Ningbo City, Not set

Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai City, Not set

Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, Shanghai, Not set

Shenzhen People's Hospital, Shenzhen City, Not set

The University of Hong Kong - Shenzhen Hospital, Shenzhen City, Not set

The Second Affiliated Hospital of Soochow University, Suzhou, Not set

Renmin Hospital of Wuhan University, Wuhan, Not set

The First Affiliated Hospital of Xian Jiao Tong University, Xi'an City, Not set

General Hospital of Ningxia Medical University, Yinchuan, Not set

Affiliated Hospital of Jiangsu University, Zhenjiang, Not set

Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set

Vseobecna fakultni nemocnice v Praze, Praha 2, Not set

Centre Hospitalier, Annonay, Not set

CHU Boulogne sur Mer, Boulogne Sur Mer, Not set

Hopital Henri Mondor, Creteil, Not set

Hopital Tenon, Paris, Not set

Hopital Bichat - Claude Bernard AP-HP, Paris, Not set

Hôpital de Rangueil, Toulouse, Not set

Universitatsklinikum der RWTH Aachen, Aachen, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Klinikum Koln-Merheim, Köln, Not set

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Not set

University General Hospital of Heraklion, Heraklion, Not set

Venizeleio General Hospital of Heraklion, Irakleio Kritis, Not set

University General Hospital of Patras, Patra, Not set

Ippokratio General Hospital of Thessaloniki, Thessaloniki, Not set

Queen Mary Hospital, Hong Kong, Not set

Azienda Ospedaliera Universitaria Federico II, Napoli, Campania

Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti, Bologna, Emilia-Romagna

Fondazione Policlinico Universitario A Gemelli, Roma, Lazio

Ospedale Policlinico San Martino, Genova, Liguria

IRCCS Pavia - Istituti Clinici Scientifici Maugeri Spa ? Società Benefit, Pavia, Lombardia

Ospedale San Giovanni Bosco, Torino, Piemonte

Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Puglia

Fujita Health University Hospital, Aichi, Not set

Hirosaki University Hospital, Aomori, Not set

Juntendo University Urayasu Hospital, Chiba, Not set

University of Yamanashi Hospital, Chuo, Not set

Matsuyama Red Cross Hospital, Ehime, Not set

Japanese Red Cross Fukuoka Hospital, Fukuoka, Not set

Hiroshima University Hospital, Hiroshima, Not set

Hokkaido University Hospital, Hokkaido, Not set

Tokyo Medical University Ibaraki Medical Center, Inashiki-Gun, Not set

Kanazawa Medical University Hospital, Ishikawa, Not set

Iwate Medical University Hospital, Iwate, Not set

Nara Medical University Hospital, Kashihara, Not set

Kumamoto University Hospital, Kumamoto, Not set

Tohoku University Hospital, Miyagi, Not set

Kyoto City Hospital, Nakagyo-ku, Not set

Nara Prefecture General Medical Center, Nara, Not set

Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Not set

Okayama University Hospital, Okayama-Shi Kita-Ku, Not set

National Hospital Organization Okayama Medical Center, Okayama, Not set

University of the Ryukyus Hospital, Okinawa, Not set

Saitama Medical University Hospital, Saitama, Not set

Osaka University Hospital, Suita, Not set

Jichi Medical University Hospital, Tochigi, Not set

Tokushima University Hospital, Tokushima, Not set

The Jikei University Hospital, Tokyo, Not set

Juntendo University Hospital, Tokyo, Not set

Tokyo Women's Medical University Hospital, Tokyo, Not set

Juntendo University Nerima Hospital, department of renal and hypertension, Tokyo, Not set

University of Tsukuba Hospital, Tsukuba, Not set

Yamaguchi University Hospital, Ube, Not set

Hallym University Sacred Heart Hospital, Anyang-si, Not set

Soon Chun Hyang University Hospital Bucheon, Bucheon-si,, Not set

Chungbuk National University Hospital, Cheongju si, Not set

Ajou University Hospital, Gyeonggi-do, Not set

CHA Bundang Medical Center, CHA University, Seongnam-si, Not set

Seoul National University Bundang Hospital, Seongnam-si, Not set

Seoul National University Hospital, Seoul, Not set

Konkuk University Medical Center, Seoul, Not set

Gangdong Kyung Hee University Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

SMG-SNU Boramae Medical Center, Seoul, Not set

Hospital Kuala Lumpur, Kuala Lumpur, FED. Territory OF Kuala Lumpur

University Malaya Medical Centre, Kuala Lumpur, FED. Territory OF Kuala Lumpur

Hospital Tengku Ampuan Afzan, Kuantan, Pahang

Hospital Seri Manjung, Seri Manjong, Pahang

Taiping Hospital, Taiping, Perak

Hospital Sibu, Sibu, Sarawak

Hospital Ampang, Ampang, Not set

Miri Hospital, Miri, Not set

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Barrio Belisario Domínguez Secc XVI, Mexico CITY (federal District)

Centro de Investigacion Clinica Chapultepec S. A. de C. V., Morelia, Michoacan

Instituto Mexicano de Trasplantes, Cuernavaca, Morelos

Christus Latam Hub Center Of Excellence & Innovation, Monterrey, Nuevo LEON

Centenario Hospital Miguel Hidalgo, Aguascalientes, Not set

SCM Clinic - Prywatny Szpital Specjalistyczny, Kraków, Not set

SPZOZ Centralny Szpital Klin, Lodz, Not set

Szpital Kliniczny im. H.Swiecickiego UM w Poznaniu, Pozna?, Not set

Szpital Kliniczny Dzieciatka Jezus, Warszawa, Not set

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu, Wroc?aw, Not set

National University Hospital, Singapore, Not set

Singapore General Hospital, Singapore, Not set

Tan Tock Seng Hospital, Singapore, Not set

Changi General Hospital, Singapore, Not set

Hospital Universitari Arnau de Vilanova, Lleida, Lerida

Hospital Universitario Vall d'Hebron - PPDS, Barcelona, Not set

Hospital Ribera Polusa, Lugo, Not set

Hospital Universitario 12 De Octubre, Madrid, Not set

Hospital Universitario La Paz - PPDS, Madrid, Not set

Hospital Universitario Virgen del Rocio - PPDS, Sevilla, Not set

Changhua Christian Hospital, Changhua, Not set

Chang Gung Medical Foundation, Kaohsiung, Not set

China Medical University Hospital, Taichung, Not set

Far Eastern Memorial Hospital, Taipei, Not set

Chang Gung Memorial Hospital, Linkou, Taoyuan City, Not set

Taichung Veterans General Hospital, Xitun Dist., Not set

Mackay Memorial Hospital-Taipei branch, Zhongshan Dist., Not set

Addenbrookes Hospital, Cambridge, Not set

Leicester General Hospital, Leicester, Not set

Guys and St Thomas Hospital, London, Not set

Kings College Hospital, London, Not set

Churchill Hospital, Oxford, Not set

Salford Royal Hospital, Salford, Not set

Conditions: Primary IgA Nephropathy

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

NCT05580562

Recruiting

This is a randomized, double-blind, placebo-controlled, parallel-group, international, Phase 3 study in patients with newly diagnosed H3 K27M-mutant diffuse glioma to assess whether treatment with ONC201 following frontline radiotherapy will extend overall survival and progression-free survival in this population. Eligible participants will have histologically diagnosed H3 K27M-mutant diffuse glioma and have completed standard frontline radiotherapy.

Gender:

ALL

Ages:

All

Trial Updated:

07/07/2025

Locations: Barrow Neurological Institute, Phoenix, Arizona +159 locations

Barrow Neurological Institute, Phoenix, Arizona

Banner MD Anderson Cancer Center, Phoenix, Arizona

Phoenix Childrens Hospital, Phoenix, Arizona

Mayo Clinic Arizona, Phoenix, Arizona

University of California Irvine, Costa Mesa, California

UC San Diego Moores Cancer Center, La Jolla, California

Kaiser Permanente Los Angeles Medical Center, Los Angeles, California

UCLA University of California Los Angeles, Los Angeles, California

Children's Hospital of Orange County, Orange, California

UCSF Benioff Children's Hospital, San Francisco, California

University of California San Francisco, San Francisco, California

Providence Saint John's Cancer Institute, Santa Monica, California

Stanford Cancer Center, Stanford, California

Yale University, Fairfield, Connecticut

MedStar Georgetown University Hospital, Washington, District of Columbia

Mayo Clinic Jacksonville, Jacksonville, Florida

Miami Cancer Institute, Miami, Florida

St Joseph's Children's Hospital of Tampa, Tampa, Florida

Moffitt Cancer Center, Tampa, Florida

Children's Healthcare of Atlanta, Atlanta, Georgia

Kapi'olani Medical Center for Women and Children, Honolulu, Hawaii

Feinberg School of Medicine Northwestern University, Chicago, Illinois

Indiana University School of Medicine - Indianapolis, Indianapolis, Indiana

University of Iowa Hospitals & Clinics, Iowa City, Iowa

Norton Healthcare, Louisville, Kentucky

Ochsner Medical Center - New Orleans, New Orleans, Louisiana

University of Maryland School of Medicine, Baltimore, Maryland

Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Dana Farber Cancer Institute, Boston, Massachusetts

University of Michigan Hospital, Ann Arbor, Michigan

University of Minnesota, Minneapolis, Minnesota

Mayo Clinic - Cancer Center - Rochester, Rochester, Minnesota

Washington University School of Medicine, Saint Louis, Missouri

Benefis Hospital Sletten Cancer Institute, Great Falls, Montana

University of Nebraska Medical Center, Omaha, Nebraska

Jersey Shore University Medical Center, Neptune, New Jersey

Overlook Medical Center, Summit, New Jersey

Albany Medical Center, Albany, New York

Children's Hospital at Montefiore Medical Center, New York, New York

Montefiore Medical Park, New York, New York

Laura & Isaac Perlmutter Cancer Center - NYU ACC, New York, New York

Columbia University Medical Center, New York, New York

Lenox Hill Hospital, New York, New York

University of Rochester Medical Center, Rochester, New York

Levine Cancer Institute/ Atrium Health, Charlotte, North Carolina

Duke Cancer Institute, Durham, North Carolina

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Cleveland Clinic, Cleveland, Ohio

Ohio State University, Columbus, Ohio

University of Oklahoma Peggy and Charles Stephenson Cancer Center, Oklahoma City, Oklahoma

Providence Health and Services St. Vincent Medical Center, Portland, Oregon

University of Pennsylvania, Philadelphia, Pennsylvania

Thomas Jefferson University, Philadelphia, Pennsylvania

UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

Dell Children's Medical Center of Central Texas, Austin, Texas

Neuro-Oncology Associates, Dallas, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

UT Health Science Center Houston Department of Neurosurgery, Houston, Texas

University of Texas - San Antonio - Health Science Center, San Antonio, Texas

University of Utah - Huntsman Cancer Institute, Salt Lake City, Utah

Inova Schar Cancer Institute, Fairfax, Virginia

Children's Hospital of The King's Daughter, Norfolk, Virginia

University of Washington, Seattle, Washington

University Of Wisconsin - Madison, Madison, Wisconsin

FLENI Neurologia, Ciudad Autónoma de Buenos Aires, Not set

Sydney Children's Hospital, Randwick, New South Wales

Royal North Shore Hospital, Sydney, New South Wales

Royal Brisbane and Women's Hospital, Herston, Queensland

Royal Hobart Hospital, Hobart, Tasmania

Olivia Newton-John Cancer Research Institute (ONJCRI), Heidelberg, Victoria

Perth Children's Hospital, Nedlands, Western Australia

Medical University of Vienna - Adults, Vienna, Wien

Medical University of Vienna - Pediatrics, Vienna, Wien

Hospital do GRAACC, São Paulo, Not set

Hcor Research Institute, São Paulo, Not set

Instituto Do Cancer Do Estado De São Paulo, São Paulo, Not set

Tom Baker Cancer Cetre, Calgary, Alberta

BC Cancer - The Vancouver Center, Vancouver, British Columbia

Children's & Women's Health Care of BC, Vancouver, British Columbia

London Health Sciences Centre, London, Ontario

Childrens Hospital of Eastern Ontario, Ottawa, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

Princess Margaret Hospital, Toronto, Ontario

Hopital Notre Dame, Lachapelle, Montréal, Quebec

Copenhagen University Hospital, Copenhagen, Capital

Aalborg Universitetshospital, Aalborg, Nordjylland

F345 H.C. Andersen's Children's Hospital, Odense, South Denmark

Odense Universitetshospital, Odense, South Denmark

University Clinic Heidelberg, Heidelberg, Baden-Württemberg

Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg

Universitätsklinikum Augsburg, Augsburg, Bayern

University Clinic Regensburg, Regensburg, Bayern

Klinikum der Johann-Wolfgang Goethe-Universitat, Frankfurt am Main, Hessen

Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen

Universitätsklinikum Essen, Essen, Nordrhein-Westfalen

Uniklinik Köln, Köln, Nordrhein-Westfalen

Vivantes Klinikum Neukölln, Berlin, Not set

Klinikum Mannheim Universitätsklinikum gGmbH, Manheim, Not set

Universitätsklinikum Tübingen, Tübingen, Not set

Queen Mary Hospital, Hong Kong, Not set

Sheba Medical Center, Ramat Gan, Tel-Aviv

Soroka University Medical Centre, Be'er Sheva, Not set

Rambam Medical Center, Haifa, Not set

Hadassah Ein Kerem Medical Center, Jerusalem, Not set

Schneider Children's Medical Center of Israel, Petah Tikvah, Not set

Rabin Medical Center, Petah Tikva, Not set

Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

Ospedale Bellaria, Bologna, Emilia-Romagna

Istituto Nazionale Tumori Regina Elena, Roma, Lazio

Ospedale San Raffaele S.r.l., Milano, Lombardia

Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo Besta, Milano, Lombardia

Istituto Clinico Humanitas, Rozzano, Lombardia

Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Piemonte

Istituto Oncologico Veneto, Padova, Veneto

National Cancer Center Hospital, Chuo City, Not set

National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set

Kyoto University Hospital, Kyoto, Not set

Osaka City General Hospital, Osaka, Not set

Hokkaido University Hospital, Sapporo, Not set

The University of Tokyo Hospital, Tokyo, Not set

CHA Bundang Medical Center, Bundang-Gu, Seongnam-Si, Gyeonggido

Seoul National University Bundang Hospital, Bundang-gu, Seongnam-si, Gyeonggido

National Cancer Center, Ilsandong-Gu, Goyang-Si, Gyeonggido

Samsung Medical Center, Gangnam-Gu, Seoul Teugbyeolsi

Gangnam Severance Hospital, Yonsei University Health System, Gangnam, Seoul Teugbyeolsi

Seoul National University Hospital, Jongno-Gu, Seoul Teugbyeolsi

Asan Medical Center, Seoul, Seoul Teugbyeolsi

Severance Hospital Yonsei University Health System, Seoul, Not set

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set

Erasmus MC, Rotterdam, Zuid-Holland

Universitair Medisch Centrum Utrecht Cancer Center, Utrecht, Not set

KK Women's and Children's Hospital, Singapore, Not set

National Cancer Centre, Singapore, Not set

National Neuroscience Institute, Singapore, Not set

Hospital Sant Joan de Deu, Esplugues De Llobregat, Barcelona

Clinica Universidad Navarra, Pamplona, Navarra

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Universitario Vall d'Hebron, Barcelona, Not set

Hospital Infantil Universitario Niño Jesus, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario HM Sanchinarro, Madrid, Not set

Complejo Asistencial Universitario de Salamanca - H. Clinico, Salamanca, Not set

Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set

Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud

Universitätsspital Zürich, Zürich, Not set

Addenbrooke's Hospital, Cambridge, Cambridgeshire

Beatson West of Scotland Cancer Centre, Glasgow, Lanarkshire

Royal Hospital for Children (Glasgow), Glasgow, Lanarkshire

Clatterbridge Cancer Centre - Liverpool, Liverpool, Lancashire

The Christie NHS Foundation Trust, Manchester, Lancashire

The Royal Marsden in Sutton, Surrey, Sutton, Surrey

Royal Victoria Infirmary, Newcastle Upon Tyne, Tyne And Wear

Freeman Hospital, Newcastle Upon Tyne, Tyne And Wear

St James University Hospital, Leeds, West Yorkshire

The Leeds Teaching Hospitals NHS Trust, Leeds General Infimary, Leeds, Not set

Guy's Hospital, London, Not set

Churchill Hospital, Oxford, Not set

Conditions: H3 K27M, Glioma

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Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

NCT06127407

Recruiting

Study CL3-95031-007 (CHONQUER) is a Phase 3, international, multicenter, double-blind, randomized, placebo-controlled study of orally administered ivosidenib. Participants are required to have a histopathological diagnosis consistent with isocitrate dehydrogenase-1 (IDH1) gene-mutated, locally advanced or metastatic conventional chondrosarcoma Grades 1, 2, or 3 and not eligible for curative resection. IDH1 mutant status will be determined during pre-screening/screening phase. Participant must ha... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: Usc Norris Comprehensive Cancer Center, Los Angeles, California +75 locations

Usc Norris Comprehensive Cancer Center, Los Angeles, California

Sarcoma Oncology Research Center, Santa Monica, California

University of Colorado Cancer Center, Aurora, Colorado

Yale Cancer Center, New Haven, Connecticut

Mayo Clinic - Jacksonville, Fl, Jacksonville, Florida

University of Miami, Miami, Florida

Emory Winship Cancer Institute, Atlanta, Georgia

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois

University of Iowa Hospitals & Clinics- Holden Comprehensive Cancer Center, Iowa City, Iowa

Dana-Farber Cancer Institute, Boston, Massachusetts

Mayo Clinic - Rochester, Mn, Rochester, Minnesota

The Washington University, Saint Louis, Missouri

Nebraska Methodist Hospital, Omaha, Nebraska

Memorial Sloan Kettering Cancer Center, New York, New York

Duke University, Durham, North Carolina

Cleveland Clinic, Cleveland, Ohio

The Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Oregon Health & Science University Knight Cancer Institute, Portland, Oregon

University of Pittsburgh Medical Center-Hillman Cancer Center, Pittsburgh, Pennsylvania

Vanderbilt University Medical Center, Nashville, Tennessee

The Univeristy of Texas Md Anderson Cancer Center, Houston, Texas

Flinders Medical Centre, Bedford Park, Not set

Chris O'Brien Lifehouse, Camperdown, Not set

St Vincent'S Hospital Melbourne, Fitzroy, Not set

Sir Charles Gairdner Hospital, Nedlands, Not set

Princess Alexandra Hospital, Woolloongabba, Not set

Hospital de Amor - Barretos, Barretos, Not set

Hospital Das Clínicas Da Ufmg, Belo Horizonte, Not set

CIONC, Curitiba, Not set

Cepon - Centro de Pesquisas Oncologicas, Florianópolis, Not set

Fundação Amaral Carvalho - Jaú/ Sp, Jaú, Not set

Instituto Nacional Do Câncer - Inca, Rio De Janeiro, Not set

Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, Not set

Impar Serviços Hospitalares S.A. - Hospital Nove de Julho, São Paulo, Not set

Hospital A C Camargo, São Paulo, Not set

Hospital Albert Einstein, São Paulo, Not set

University Health Network, Toronto, Ontario

Muhc Glen Site, Montréal, Quebec

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei

Shanghai General Hospital, Shanghai, Shanghai

West China Hopital of Sichuan University, Chengdu, Sichuan

The Second Affiliated Hospital Zhejiang University School of Medical, Hangzhou, Zhejiang

Helios Klinikum Bad Saarow, Bad Saarow, Not set

Charite Universitatsmedizin, Berlin, Not set

Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set

Universitätsmedizin Mannheim (Umm), Mannheim, Not set

Lmu Klinikum, Muenchen, Not set

Aou Policlinico Paolo Giaccone, Palermo, Not set

Ospedale Santo Stefano, Prato, Not set

Policlinico Universitario Campus Biomedico, Roma, Not set

Istituti Fisioterapici Ospitalieri (Ifo) - Istituto Nazionale Tumori Regina Elena (Ire), Roma, Not set

Hokkaido Cancer Center, Sapporo, Hokkaido

Kanazawa University Hospital, Kanazawa, Ishikawa

Nagoya University Hospital, Showa-ku, Nagoya-shi, Aichi

Oita University Hospital, Yufu-Shi, Oita

Osaka International Cancer Institute, Chuo Ku, Osaka-shi, Osaka

National Cancer Center Hospital, Chuo-ku, Tokyo, Not set

Kyushu University Hospital, Higashi, Not set

Cancer Institute Hospital of Jfcr, Koto-Ku, Tokyo, Not set

Okayama University Hospital, Okayama, Not set

Universitair Medisch Centrum Groningen (Umcg), Groningen, Not set

Leids Universitair Medisch Centrum, Leiden, Not set

Radboud Umc, Nijmegen, Not set

Hospital Universitario Valle de Hebrón - Vhio, Barcelona, Not set

Hospital de La Santa Creu I Sant Pau, Barcelona, Not set

Hospital de Bellvitge - Ico, L'Hospitalet De Llobregat, Not set

Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Y Politecnico La Fe, Valencia, Not set

National Taiwan University Hospital, Taipei, Not set

Western General Hospital, Edinburgh, Not set

Royal Marsden Hospital, London, Not set

UCLH, London, Not set

Christie Hospital, Manchester, Not set

Churchill Hospital, Oxford, Not set

Conditions: Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

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