Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis
NCT06256575
Recruiting
This study is performed to consider the safety and healing ability of diosmin in patients with systemic sclerosis (scleroderma) and open sores on their fingers (digital ulcers). Two (2) out of three (3) participants will receive active product. The participants will have four (4) visits over eight (8) weeks. Physical exams and photos will be performed. A variety of questions will be asked describing level of pain and lifestyle changes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/05/2025
Locations: Saint Joseph Health Care Centre, London, Ontario +1 locations
Conditions: Scleroderma, Systemic, Digital Ulcer
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iP2P Mentorship Program for Adolescent HF Patients
NCT05709132
Recruiting
The iPeer2Peer (iP2P) program is an online peer support mentorship program that provides modelling and reinforcement by trained young adult peer mentors to adolescent mentees with the same condition. A quasi-experimental single-arm pre-post study design will be employed across three sites. We will recruit 40 mentees (12-17 years of age) and 12-15 mentors (18-30 years of age) who will undergo training in mentoring and the use of eHealth technology. Mentor-mentee pairings will connect over 15 week... Read More
Gender:
ALL
Ages:
Between 12 years and 30 years
Trial Updated:
07/04/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Heart Failure
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Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
NCT05849129
Recruiting
This is a two arm RCT evaluating the effect of intravenous vitamin C versus placebo in patients with incurable non-small cell lung cancer. Participants in both arms will be receiving platinum doublet chemotherapy with or without concurrent immunotherapy as standard care. We plan to enroll 90 patients over 5 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/04/2025
Locations: The Ottawa Hospital, Ottawa, Ontario
Conditions: Lung Cancer
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A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work
NCT06290128
Recruiting
The purpose of the study is to evaluate efficacy of riliprubart compared to placebo in adult participants with CIDP whose disease is refractory to standard of care. The study duration will be for a maximum of 111 weeks including screening, treatment phases, and follow-up.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/04/2025
Locations: Alabama Neurology Associates- Site Number : 8400019, Homewood, Alabama +104 locations
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Polyneuropathy, Inflammatory Demyelinating, Chronic
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A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies
NCT05081609
Recruiting
TransCon IL-2 β/γ is an investigational drug being developed for treatment of locally advanced or metastatic solid tumors. This is a first-in-human, open-label, Phase 1/2, dose escalation and dose expansion study of TransCon IL-2 β/γ as monotherapy or in combination therapy in adult participants with advanced or metastatic solid tumors. Given the unique PK profile enabled by the TransCon technology, TransCon IL-2 β/γ presents the opportunity to enhance the therapeutic index of current IL-2 thera... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/04/2025
Locations: Ascendis Pharma Investigational Site, Los Angeles, California +68 locations
Conditions: Advanced Solid Tumor, Locally Advanced Solid Tumor, Metastatic Solid Tumor, Platinum-resistant Ovarian Cancer, Post Anti-PD-1 Melanoma, 2L+ Cervical Cancer, Neoadjuvant Melanoma, Neoadjuvant Non-Small Cell Lung Cancer, Post Anti-PD-(L)1 Non-Small Cell Lung Cancer, Post Anti-PD-(L)1 Small Cell Lung Cancer, Third Line or Later (3L+) HER2+ Breast Cancer, Second or Third Line (2L/3L) Cervical Cancer, Third-line or Later (3L+) Platinum-resistant Ovarian Cancer (PROC)
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A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
NCT05711394
Recruiting
A migraine is a moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms. A number of treatments are available for adults with migraine but there are limited approved treatments available for pediatric participants. The main goal of the study is to evaluate the safety and efficacy (how well treatment works) of a low-dose and high-dose of atogepant in pediatric par... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
07/04/2025
Locations: Rehabilitation & Neurological Services /ID# 248517, Huntsville, Alabama +93 locations
Conditions: Episodic Migraine
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Implementation of Personalized Medicine for Optimal Drug Therapy in Cancer
NCT05830279
Recruiting
A prospective longitudinal cohort study that will assess the effect of a Personalized Medicine (PM) clinic recommendations on pharmacogenetic variation and/or interacting drugs on plasma drug exposure, effectiveness or toxicity of commonly used antidepressant, pain, and antiemetic medications in cancer patients. Such recommendations will entail genotype-guided treatment suggestions while also considering potential DDI, and will be provided to patients during their clinic visit, and referring phy... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/04/2025
Locations: Lawson Health Research Institute, London, Ontario
Conditions: Nausea With Vomiting Chemotherapy-Induced, Depression, Reactive, Cancer Pain
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Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback
NCT06873841
Recruiting
The goal of this clinical trial is to compare the effectiveness of CoPs therapy with or without the therapeutic component of biofeedback in treating tics in Tourette Syndrome with emerging young adults. Hypotheses: 1. The CoPs+Biofeedback treatment will improve the severity of tics (YGTSS) and the Clinical Global Impression, surpassing the clinical significance threshold of CoPs treatment alone. 2. We expect that the identified variables (psychosocial, neurocognitive, biological) will predict... Read More
Gender:
ALL
Ages:
Between 14 years and 21 years
Trial Updated:
07/04/2025
Locations: Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal, Hôpital Rivières-des-Prairies, Montréal, Quebec
Conditions: Tourette Syndrome, Tics, Tourette Syndrome in Adolescence
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Effects of Resistance Exercise on Blood Glucose in Post-menopausal Women With Type 1 Diabetes
NCT05203640
Recruiting
Regular physical activity has substantial health benefits in people with type 1 diabetes. The fear of hypoglycemia, both during and after exercise, is a major barrier to exercise in this population. A major obstacle to providing specific physical activity and exercise advice is that there are still significant gaps in the fundamental understanding of the impact of physical activity and exercise on blood glucose levels in type 1 diabetes. Women with type 1 diabetes have a substantial increase in... Read More
Gender:
FEMALE
Ages:
Between 45 years and 75 years
Trial Updated:
07/04/2025
Locations: Alberta Diabetes Institute, Edmonton, Alberta
Conditions: Type 1 Diabetes
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Exercise and the Menstrual Cycle in Type 1 Diabetes
NCT05188014
Recruiting
Female participants with type 1 diabetes using oral contraceptives will be asked to wear a continuous glucose monitor for at least three days on two separate occasions (once during the last week of active pills and once during the no pill/placebo pill phase of the menstrual cycle). An exercise session (45 minutes of aerobic exercise at 60% VO2peak on a cycle ergometer) will take place at 5 pm on the second day of glucose monitoring.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
07/04/2025
Locations: Alberta Diabetes Institute, Edmonton, Alberta
Conditions: Type 1 Diabetes
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A Study of MK-4700 Alone or With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors (MK-4700-001)
NCT06894771
Recruiting
The goal of this study is to learn about the safety of different doses of MK-4700 and if people tolerate them. The study will also measure what happens in a person's body over time when MK-4700 is given alone or with pembrolizumab (MK-3475) in order to find a dose that is safe, tolerated, and may work to treat certain types of cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/04/2025
Locations: John Theurer Cancer Center at Hackensack University Medical Center ( Site 0301), Hackensack, New Jersey +5 locations
Conditions: Malignant Neoplasm
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Establishing and Validating a Meal-provoked Intestinal Permeability Test for Nutritional and Metabolic Health Clinical Research.
NCT07066176
Recruiting
Development of Intestinal Permeability Tests for Clinical Nutrition and Metabolic Health Studies
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/04/2025
Locations: INAF, Québec, Quebec
Conditions: Intestinal Permeability
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