Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma
NCT06319196
Recruiting
Clear-Me is a biomarker-driven phase II study that tests whether the combination anti- lymphocyte-activation gene-3 (LAG3)/anti-programmed cell death protein 1(PD-1) inhibition Bristol-Myers Squibb (BMS986213) is superior to anti-PD-1 inhibition in patients with detectable circulating tumor deoxyribonucleic acid (ctDNA) following definitive surgery for high risk melanoma. Patients will be allocated to either Arm A or Arm B via the process of randomization. The randomization process will be strat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/30/2025
Locations: UHN- Princess Margaret Cancer Center, Toronto, Ontario
Conditions: Cutaneous Melanoma, Melanoma Stage IV, Mucosal Melanoma
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Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
NCT03573089
Recruiting
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/29/2025
Locations: Royal Prince Alfred Hosptial, Camperdown, New South Wales +114 locations
Conditions: Kidney Failure, Chronic, Hyperphosphatemia
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Study of TBI-2001(Autologous CD19 Specific Chimeric Antigen Receptor (CAR) Gene-transduced T Lymphocytes) for Relapsed or Refractory CD19+ B-cell Lymphoma, CLL/SLL
NCT05963217
Recruiting
This is a Phase 1/1b, open-label, dose-escalation study to evaluate the safety and the efficacy of anti-CD19 chimeric antigen receptor (CAR) (TBI-2001) for relapsed or refractory CD19+ B-cell lymphoma Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Relapsed or Refractory CD19+ B-cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma
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A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity
NCT06780449
Recruiting
This study will look at how well CagriSema helps people with obesity lose weight compared to a "dummy medicine". CagriSema is a new medicine developed by Novo Nordisk. CagriSema cannot yet be prescribed by doctors. The study has two parts: First part is called the main phase and will last for 2 years, and second part is called the extension phase and will last for 1 year. In the main phase participants will either get CagriSema or "dummy medicine". Which treatment participants get is decided by... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Valley Clinical Trials, Covina, California +36 locations
Conditions: Obesity
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Power Over Pain Portal: A Stepped-care Virtual Solution to Deliver Early Intervention to Canadian Youth With Chronic Pain
NCT06076889
Recruiting
The COVID-19 pandemic is presenting one of the greatest threats to youth mental health seen in generations. Pain is one of the most common symptoms of extreme stress in youth. In 2020, the investigators created an online "stepped-care" program called the Power over Pain Portal. Stepped care is a promising way to improve access to CP care. Stepped care tailors care based on a person's symptom severity. Like a ladder, a person must start with one type of care then "step up" or "step down" to more... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
06/27/2025
Locations: The Hospital for Sick Children, Toronto, Ontario
Conditions: Chronic Pain
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A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age
NCT05575492
Recruiting
The main purpose of study is to evaluate the safety and immunogenicity of different dose levels of mRNA-1647 versus control in healthy cytomegalovirus (CMV)-seronegative and CMV-seropositive female and male participants 9 to 15 years of age. In addition, mRNA-1647 will be evaluated in female participants 16 to 25 years as a comparator cohort.
Gender:
ALL
Ages:
Between 9 years and 25 years
Trial Updated:
06/27/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +70 locations
Conditions: Cytomegalovirus
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Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!)
NCT05196087
Recruiting
Patients who have undergone curative treatment may be at risk of relapse. This study will collect, annotate, and sequence biospecimens (blood, stool, and tissue) from patients across different tumor types to detect molecular residual disease (MRD) before metastases become radiographically or clinically detectable. This will allow for early cancer interception, and hopefully prolong relapse-free survival across tumor types.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Breast Cancer, Melanoma, Gastrointestinal Neuroendocrine Tumor
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24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 - <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up
NCT05677451
Recruiting
The purpose of this trial is: 1. to assess the efficacy, pharmacokinetics, and safety of remibrutinib vs. placebo in adolescents from 12 to \< 18 years of age suffering from chronic spontaneous urticaria inadequately controlled by H1-antihistamines 2. to collect long-term efficacy, safety and tolerability data on remibrutinib in adolescents after having completed 24 weeks of treatment 3. to collect safety data in this population for up to three years after the last dose of study treatment
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
06/27/2025
Locations: Kern Research, Bakersfield, California +62 locations
Conditions: Chronic Spontaneous Urticaria
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Cognitive Groove (Brought to You by GERAS DANCE)
NCT06870149
Recruiting
The goal of this clinical trial is to determine the effect of a community-based rehabilitation intervention (Cognitive Groove, Brought to you by GERAS DANCE), compared to usual care, on clinical outcomes in community-dwelling older adults living with frailty. The main questions it aims to answer are: 1. In community-dwelling older adults living with frailty, is Cognitive Groove more effective than usual care in improving functional movement, physical performance and strength? 2. In community-dw... Read More
Gender:
ALL
Ages:
Between 65 years and 100 years
Trial Updated:
06/27/2025
Locations: Geras Centre for Aging Research, St. Peter's Hospital, Hamilton Health Sciences, Hamilton, Ontario
Conditions: Frailty, Frail Older Adults, Frailty in Aging, Frailty Syndrome
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The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
NCT04947722
Recruiting
Hip fractures occur nearly twice as often for older adults residing in long-term care as they do in older adults of a similar age still living in other settings. Hip fractures are the leading cause of hospitalization and often result in loss of independence, problems with walking and sometimes death. To address this problem the PREVENT (Person-centered Routine Fracture PrEVENTion in LTC) program was designed for use in long-term care homes. PREVENT uses a tool ("fracture risk calculator") based... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/27/2025
Locations: McMaster University - St. Peter's Hospital, Hamilton, Ontario
Conditions: Fracture, Fractures, Hip, Osteoporosis
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FitJoints: Getting Fit for Hip and Knee Replacement
NCT05100966
Recruiting
Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis. The number of people waiting for elective surgeries has spiked in the COVID-19 pandemic. Prior to COVID-19, up to 40% of patients receiving joint replacement were frail and this number is rapidly increasing with longer wait-times and deconditioning associated with COVID-19 physical distancing. There is an urgent need to be r... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
06/27/2025
Locations: Foothill Medical Centre - Alberta Health Services, Calgary, Alberta +3 locations
Conditions: Hip Osteoarthritis, Knee Osteoarthritis
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LANDscape MApping of Epitopes and T Cell Receptors for Selected Cancers
NCT04665388
Recruiting
This is a correlative research project aimed at characterizing the T cell mediated immune responses to hepatocellular carcinoma (HCC), as well as Epstein-Barr virus (EBV)- and human papillomavirus (HPV)-related cancers. This study will enroll approximately 105 patients over 48 months. Of these 105 patients, 30 are EBV-related cancer, 45 are HPV-related cancer, and 30 are HCC. Patients will have blood samples collected one time to identify cancer specific T cells and T cell receptors in their blo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Solid Tumor
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