There are currently 24 active clinical trials seeking participants for Malignant Neoplasm research studies. The states with the highest number of trials for Malignant Neoplasm participants are Michigan, Illinois, Nevada and California.
New Assessment System in Measuring Symptom Distress in Cancer Patients
NCT00505245
Recruiting
This trial studies how well a new assessment system (MDASI or other MD Anderson-developed PRO instrument) works in measuring symptoms and the impact on quality of life in cancer patients. Development of a new assessment system may provide more information about the common symptoms that may occur in patients due to cancer and its treatment and how the symptoms impact quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Caregiver, Health Care Provider, Malignant Neoplasm, Physician
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A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)
NCT06941272
Recruiting
Researchers are looking for new ways to treat children with hepatoblastoma or rhabdomyosarcoma (RMS) that has relapsed or is refractory: * Hepatoblastoma is a common liver cancer in babies and very young children * RMS is a cancer that starts in muscle cells, often in a child's head and neck, bladder, arms, or legs * Relapsed means the cancer came back after treatment * Refractory means the cancer did not respond (get smaller or go away) to treatment The study treatment HER3-DXd (also known as... Read More
Gender:
ALL
Ages:
Between 1 month and 17 years
Trial Updated:
07/25/2025
Locations: University of Iowa Health Care Holden Comprehensive Cancer Center ( Site 3017), Iowa City, Iowa +9 locations
Conditions: Malignant Neoplasm
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A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)
NCT06818643
Recruiting
Researchers are looking for new ways to treat people with certain advanced solid tumors. Advanced means the cancer has spread to other parts of the body and cannot be removed with surgery. Solid tumors are cancers mostly in body organs and tissues, not in the blood or other body liquids. The main goal of this study is to learn about the safety of MK-3120 and if people tolerate it.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: John Theurer Cancer Center at Hackensack University Medical Center ( Site 1009), Hackensack, New Jersey +25 locations
Conditions: Advanced Solid Tumors, Malignant Neoplasm
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Project: Every Child for Younger Patients With Cancer
NCT02402244
Recruiting
This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
Gender:
ALL
Ages:
25 years and below
Trial Updated:
07/10/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +241 locations
Conditions: Central Nervous System Neoplasm, Childhood Immature Teratoma, Childhood Langerhans Cell Histiocytosis, Childhood Mature Teratoma, Congenital Mesoblastic Nephroma, Lymphoproliferative Disorder, Myeloproliferative Neoplasm, Stromal Neoplasm, Carcinoma In Situ, Malignant Solid Neoplasm, Desmoid Fibromatosis, Ganglioneuroma, Melanocytic Neoplasm, Neuroendocrine Neoplasm, Adrenal Gland Pheochromocytoma, Malignant Neoplasm, Neoplasm of Uncertain Malignant Potential, Childhood Kidney Neoplasm
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Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers
NCT03207854
Recruiting
This research trial collects and stores blood, tissue, and bone marrow specimens from patients with cancer or blood disorders, and healthy volunteers to study the immune system in a variety of different types of experiments, as well as associated clinical data as appropriate, focused on understanding mechanisms of immunotherapy.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
07/10/2025
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Healthy Subject, Hematologic and Lymphocytic Disorder, Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder, Malignant Neoplasm
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Virtual Reality in Reducing Pain and Anxiety in Cancer Participants Undergoing Painful Procedures
NCT03568292
Recruiting
This trial studies how well virtual reality (VR) works in reducing pain and anxiety in cancer participants undergoing bone marrow biopsy or lumbar puncture. Virtual reality may impact pain and anxiety during and after the procedure.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/10/2025
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Malignant Neoplasm
Register for Updates
Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus
NCT02479698
Recruiting
This phase II trial studies how well donor cytotoxic T lymphocytes work in treating patients with malignancies with BK and/or JC virus. Cytotoxic T lymphocytes are made from donated blood cells that are grown in the laboratory and are designed to kill viruses that can cause infections in transplant patients and may be an effective treatment in patients with malignancies with BK and/or JC virus.
Gender:
ALL
Ages:
All
Trial Updated:
07/09/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Acquired Immunodeficiency Syndrome, BK Virus Infection, Human Immunodeficiency Virus, JC Virus Infection, Malignant Neoplasm, Merkel Cell Carcinoma, Merkel Cell Polyomavirus Infection, Viral Encephalitis
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A Study of MK-4700 Alone or With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors (MK-4700-001)
NCT06894771
Recruiting
The goal of this study is to learn about the safety of different doses of MK-4700 and if people tolerate them. The study will also measure what happens in a person's body over time when MK-4700 is given alone or with pembrolizumab (MK-3475) in order to find a dose that is safe, tolerated, and may work to treat certain types of cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/04/2025
Locations: John Theurer Cancer Center at Hackensack University Medical Center ( Site 0301), Hackensack, New Jersey +5 locations
Conditions: Malignant Neoplasm
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Molecular Genetics Studies of Cancer Patients and Their Relatives
NCT04185935
Recruiting
This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.
Gender:
ALL
Ages:
All
Trial Updated:
06/23/2025
Locations: Valleywise Comprehensive Health Center - Phoenix, Phoenix, Arizona +41 locations
Conditions: Malignant Neoplasm
Register for Updates
Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials
NCT05886764
Recruiting
This trial will study different outreach methods to assess impact on enrollment of underrepresented minorities (specifically African Americans) to early phase cancer clinical treatment trials. Both patients and providers (those seeing enrolled patients) will be enrolled and receive the study interventions or no intervention (control arm).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/06/2025
Locations: University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois
Conditions: Cancer, Malignancy, Malignant Neoplasm
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Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing
NCT06207864
Recruiting
This clinical trial studies engagement strategies for recruiting American Indians (AI) of Southwestern Tribal Nations for cancer genome sequencing. American Indians in the Southwest have higher rates of some types of cancer, such as cancers that arise in the liver, kidney, breast, and colon. American Indians with cancer may also live for less time than people from other population groups who have been treated for the same cancer. Damage to the cells of the body, acquired as people live, grow old... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Conditions: Malignant Neoplasm
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Intraoperative Tumor Margin Identification With ICG Dye Imaging
NCT04752137
Recruiting
In this research study we want to learn more about the use of indocyanine green (ICG) during bone or soft tissue mass resections. Indocyanine green (ICG) is a type of dye that is used in medical diagnostics. We want to determine if ICG-guided tumor resection is more effective in obtaining negative margins. Lastly, we want to assess traditional oncologic outcomes of local recurrence, time to metastatic disease, and overall and disease specific survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Benign Neoplasm, Malignant Neoplasm
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