There are currently 15 active clinical trials seeking participants for Osteoporosis research studies. The states with the highest number of trials for Osteoporosis participants are California, Florida, Illinois and Pennsylvania.
RESTORE: REducing Future FractureS and Improving OuTcOmes of FRagility FracturE
Recruiting
RESTORE tests whether Augmented-FLS, where patients are contacted by a patient navigator (serving as the liaison) and referred to a bone health provider, is better than Enhanced Usual Care, which includes patient and PCP education and activation. We also aim to determine the influence of age, race, ethnicity, sex, poverty level, geographic region, and timing of entry into the trial after a fracture on the effectiveness of the two strategies.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
01/30/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Osteoporosis, Osteoporotic Fractures
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
Recruiting
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty. The main question this study aims to answer is: 1) What is impact of a surgeon-driven bone health referral pathway on implant-related complications and fragility fractures when compared to standard of care primary care provider referral. Researchers will compare the endocrinology referral pathway and standard of care to see if there is a difference i... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
10/28/2024
Locations: Charter Professional Center, Columbia, Maryland
Conditions: Osteoporosis, Arthroplasty Complications, Fragility Fracture
Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
Recruiting
People with Alzheimer's disease are at an increased risk of bone fracture. Some studies have shown that those taking donepezil have a lower rate of bone fractures, but the reasons for this are unknown. The purpose of this study is to measure the effect of donepezil treatment on bone metabolism factors including bone mineral density, bone turnover markers, and bone quality. Participants in this study will have a bone density test and have blood samples collected at the baseline study visit. Part... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
10/07/2024
Locations: Duke Memory Disorders Clinic, Durham, North Carolina
Conditions: Osteoporosis
Romosozumab Use to Build Skeletal Integrity
Recruiting
The purpose of this study is to find out if one year of romosozumab (Evenity®), a monthly injection given in the arm under the skin, prior to an infusion of zoledronic acid Reclast®, works to treat bone loss and prevent it from worsening in older women (ages 65 and older) who have osteoporosis and reside in long-term care (LTC) facilities.
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
09/09/2024
Locations: UPMC Senior Communities, Pittsburgh, Pennsylvania
Conditions: Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Fracture
Trial of Parkinson's and Zoledronic Acid
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/03/2024
Locations: Mayo Clinic, Scottsdale, Arizona +77 locations
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
PTH And Calcium Responses to Exercise in Older Adults Experiment 2 (PACE Sr. 2)
Recruiting
Declines in serum calcium during exercise may cause increases in markers of bone resorption. This study will determine if preventing the decline serum ionized calcium experienced at the onset of exercise through the use of a "calcium clamp" also prevents increases in blood biomarkers associated with bone resorption.
Gender:
FEMALE
Ages:
Between 60 years and 80 years
Trial Updated:
08/05/2024
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Osteoporosis
Mode of Exercise and Bone Biomarkers in Older Veterans
Recruiting
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences b... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
06/18/2024
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado
Conditions: Aging, Musculoskeletal Diseases, Osteoporosis
Skeletal Response to Simulated Night Shift
Recruiting
This small intervention study will determine if simulated short-term night shift work (NSW) negatively alters bone metabolism. The specific aim of the study is to determine if NSW acutely uncouples bone turnover markers (BTMs), if sympathetic tone is a mechanism for this disruption and if a resumption of a normal sleep/wake pattern reverses BTM uncoupling. Our hypothesis is that NSW will reversibly uncouple BTMs via increased sympathetic nervous system (SNS) tone.
Gender:
All
Ages:
Between 20 years and 40 years
Trial Updated:
06/14/2024
Locations: CU Anschutz, Aurora, Colorado
Conditions: Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
Recruiting
Proton pump inhibitors (PPIs) are widely used for the control of gastric ulcer-gastritis, erosive esophagitis (gastroesophageal reflux disease), peptic ulcer disease (duodenal ulcer), and heartburn. Despite their efficacy, their use has been implicated in possibly causing fragility fractures (osteoporosis), hypomagnesemia (magnesium deficiency) and increased risk of chronic kidney disease (CKD). The current trial represents the investigators ongoing effort to discern whether these complications... Read More
Gender:
All
Ages:
Between 21 years and 99 years
Trial Updated:
05/21/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas +1 locations
Conditions: Osteoporosis, Hypomagnesemia
Skeletal Effects of Chronic Night Shift
Recruiting
The specific aim of this observational study is to characterize changes in bone turnover makers (BTMs), bone mineral density (BMD), and bone microarchitecture in a cohort of nurses during their first year of night compared to day shift work. The hypothesis is that night shift nurses will have poorer bone health indices at one year compared to day shift nurses.
Gender:
All
Ages:
Between 20 years and 50 years
Trial Updated:
05/10/2024
Locations: CU Anschutz, Aurora, Colorado
Conditions: Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
Effect of Soluble Corn Fiber Supplementation for 1 Year on Bone Metabolism in Adolescents
Recruiting
The primary aim of this proposal is to determine the effects of soluble corn fiber (SCF) supplementation for 1 year on bone metabolism in growing adolescents compared to controls. For the proposed study, a randomized double-blinded placebo controlled clinical trial will be conducted in 236 healthy adolescents aged 10-13 years, equally randomly assigned to one of four intervention groups: SCF (12 g/d), SCF + calcium (12 g/d of SCF + 600 mg/d of elemental calcium), placebo (0 g/d of SCF or of calc... Read More
Gender:
All
Ages:
Between 9 years and 14 years
Trial Updated:
05/01/2024
Locations: Nicklaus Childrens Hospital, Miami, Florida
Conditions: Osteoporosis
Preserving Geriatric Muscle With an Osteoporosis Medication
Recruiting
Our goal is to demonstrate efficacy of the novel agent Denosumab to improve or preserve muscle health, strength, mobility and function in frail older adults.
Gender:
All
Ages:
65 years and above
Trial Updated:
03/28/2024
Locations: St. Barnabas Woodlands, Pittsburgh, Pennsylvania
Conditions: Osteoporosis