There are currently 16 active clinical trials seeking participants for Osteoporosis research studies. The states with the highest number of trials for Autism participants are California, Florida, Illinois and Pennsylvania.
Sacral Fracture Fusion/Fixation for Rapid Rehabilitation
NCT05426356
Recruiting
To determine the safety and efficacy of concomitant sacral fracture fixation and sacroiliac (SI) joint fusion vs. non-surgical management for patients with debilitating sacral fragility or insufficiency fractures
Gender:
All
Ages:
60 years and above
Trial Updated:
04/12/2024
Locations: UC Davis Department of Orthopaedic Surgery, Davis, California +11 locations
Conditions: Fracture;Pelvis, Sacral Fracture, Sacroiliac; Fusion, Fragility Fracture, Insufficiency Fractures, Osteoporosis
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Preserving Geriatric Muscle With an Osteoporosis Medication
NCT06118905
Recruiting
Our goal is to demonstrate efficacy of the novel agent Denosumab to improve or preserve muscle health, strength, mobility and function in frail older adults.
Gender:
All
Ages:
65 years and above
Trial Updated:
03/28/2024
Locations: St. Barnabas Woodlands, Pittsburgh, Pennsylvania
Conditions: Osteoporosis
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Treatment With Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
NCT05180032
Recruiting
The objective of the proposed work is to determine whether administration for 12 months of romosozumab (evenity) followed by 12 months of denosumab (prolia) will maintain bone mass at the knee in subjects with chronic SCI.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/21/2024
Locations: Kessler Institute for Rehabilitation, West Orange, New Jersey +1 locations
Conditions: Osteoporosis, Spinal Cord Injuries
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PatientSpot Formerly Known as ArthritisPower
NCT03840928
Recruiting
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with rheumatoid arthritis (RA), spondyloarthritis (SpA), other musculoskeletal conditions, chronic neurological conditions like migraine, chronic pulmonary conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, autoimmune dermatological conditions such as psor... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
12/12/2023
Locations: Global Healthy Living Foundation, Upper Nyack, New York
Conditions: Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout, Crohn Disease, Juvenile Idiopathic Arthritis, Lupus Erythematosus, Myositis, Osteoarthritis, Osteoporosis, Psoriasis, Psoriatic Arthritis, Scleroderma, Dermatomyositis, Inflammatory Bowel Diseases, Polymyositis, Axial Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis, Polymyalgia Rheumatica, Giant Cell Arteritis, Temporal Arteritis, Wegener, Relapsing Polychondritis, Undifferentiated Connective Tissue Disease, Spinal Cord Injuries, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Ataxia, Bell Palsy, Brain Tumor, Cerebral Aneurysm, Epilepsy, Guillain-Barre Syndrome, Headache, Head Injury, Hydrocephalus, Lumbar Disc Disease, Meningitis, Multiple Sclerosis, Muscular Dystrophy, Neurocutaneous Syndromes, Parkinson Disease, Stroke, Cluster Headache, Tension-Type Headache, Chronic Obstructive Pulmonary Disease, Asthma, Lung Cancer, Cystic Fibrosis, Sleep Apnea, Eczema, Alopecia, Chronic Inflammation, Unstable Angina, Heart Attack, Heart Failure, Arrythmia, Valve Heart Disease, High Blood Pressure, Congenital Heart Disease, Peripheral Arterial Disease, Diabetes, Chronic Liver Disease, Obesity
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PTH And Calcium Responses to Exercise in Older Adults Experiment 2 (PACE Sr. 2)
NCT02580604
Recruiting
Declines in serum calcium during exercise may cause increases in markers of bone resorption. This study will determine if preventing the decline serum ionized calcium experienced at the onset of exercise through the use of a "calcium clamp" also prevents increases in blood biomarkers associated with bone resorption.
Gender:
Female
Ages:
Between 60 years and 80 years
Trial Updated:
11/14/2023
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Osteoporosis
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Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
NCT05845021
Recruiting
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty. The main question this study aims to answer is: 1) What is impact of a surgeon-driven bone health referral pathway on implant-related complications and fragility fractures when compared to standard of care primary care provider referral. Researchers will compare the endocrinology referral pathway and standard of care to see if there is a difference i... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
11/07/2023
Locations: Charter Professional Center, Columbia, Maryland
Conditions: Osteoporosis, Arthroplasty Complications, Fragility Fracture
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A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis
NCT05775094
Recruiting
The purpose of this study is to measure the effect of romosozumab on bone formation and breakdown (resorption) and determine if romosozumab is a safe treatment for osteoporosis and myeloma-related bone disease (MBD) in postmenopausal people with multiple myeloma (MM).
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Multiple Myeloma, Osteoporosis
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Skeletal Response to Simulated Night Shift
NCT05074277
Recruiting
This small intervention study will determine if simulated short-term night shift work (NSW) negatively alters bone metabolism. The specific aim of the study is to determine if NSW acutely uncouples bone turnover markers (BTMs), if sympathetic tone is a mechanism for this disruption and if a resumption of a normal sleep/wake pattern reverses BTM uncoupling. Our hypothesis is that NSW will reversibly uncouple BTMs via increased sympathetic nervous system (SNS) tone.
Gender:
All
Ages:
Between 20 years and 40 years
Trial Updated:
10/19/2023
Locations: CU Anschutz, Aurora, Colorado
Conditions: Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
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Skeletal Effects of Chronic Night Shift
NCT05091021
Recruiting
The specific aim of this observational study is to characterize changes in bone turnover makers (BTMs), bone mineral density (BMD), and bone microarchitecture in a cohort of nurses during their first year of night compared to day shift work. The hypothesis is that night shift nurses will have poorer bone health indices at one year compared to day shift nurses.
Gender:
All
Ages:
Between 20 years and 50 years
Trial Updated:
10/19/2023
Locations: CU Anschutz, Aurora, Colorado
Conditions: Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
Register for Updates
Romosozumab Use to Build Skeletal Integrity
NCT05058976
Recruiting
The purpose of this study is to find out if one year of romosozumab (Evenity®), a monthly injection given in the arm under the skin, prior to an infusion of zoledronic acid Reclast®, works to treat bone loss and prevent it from worsening in older women (ages 65 and older) who have osteoporosis and reside in long-term care (LTC) facilities.
Gender:
Female
Ages:
65 years and above
Trial Updated:
09/08/2023
Locations: UPMC Senior Communities, Pittsburgh, Pennsylvania
Conditions: Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Fracture
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Trial of Parkinson's And Zoledronic Acid
NCT03924414
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Mayo Clinic, Scottsdale, Arizona +66 locations
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
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Mode of Exercise and Bone Biomarkers in Older Veterans
NCT05266976
Recruiting
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences b... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/06/2023
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado
Conditions: Aging, Musculoskeletal Diseases, Osteoporosis
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