There are currently 248 clinical trials in Irvine, California looking for participants to engage in research studies. Trials are conducted at various facilities, including University of California, Irvine, Kaiser Permanente-Irvine, City of Hope at Irvine Lennar and Masimo Corporation. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of PULSAR-ICI +/- IMSA101 in Patients With Oligometastatic NSCLC and RCC
NCT05846646
Recruiting
Phase 2, open-label, multicenter, randomized study comparing the safety and efficacy of personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) combined with immune checkpoint inhibitor (ICI) immunotherapy (PULSAR-ICI) + IMSA101 and PULSAR-ICI alone in patients with NSCLC or RCC
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California
Conditions: Oligometastatic Disease
Register for Updates
Dementia Family Caregiver Study
NCT04894006
Recruiting
The proposed study will test a 3-month, community health worker (CHW) delivered home visit, culturally and language-appropriate intervention for ethnic and underserved dementia family caregivers of persons with dementia (PWD) using wearable technology for real time monitoring of caregivers' stress and sleep. The CHW delivered home visit intervention includes stress reduction techniques by mindful deep breathing and compassionate support/listening and caregiving education to improve caregiver's h... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Dementia Caregiver
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Study of PULSAR-ICI +/- IMSA101 in Patients With Oligoprogressive Solid Tumor Malignancies
NCT05846659
Recruiting
Phase 2, open-label, multicenter, randomized study comparing the safety and efficacy of personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) combined with immune checkpoint inhibitor (ICI) immunotherapy (PULSAR-ICI) + IMSA101 and PULSAR-ICI alone in patients with oligoprogressive solid tumor malignancies after prior anti-cancer therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California
Conditions: Oligoprogressive
Register for Updates
ICG Fluorescence Imaging in Post-traumatic Infection
NCT04403204
Recruiting
The focus of this prospective observational study is to (1) establish the range and variation associated with bone/soft tissue perfusion in fracture patients, using ICG fluorescence imaging; (2) examine the relationship between perfusion and complications such as surgical site infection (SSI), persistent SSI, and fracture nonunion; (3) to determine whether the quantitative ICG fluorescence can be used to guide bony debridement in the setting of infected fracture to minimize complications.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Trauma Injury
Register for Updates
ICG Fluorescence Imaging in Open Fracture Trauma Patients
NCT04416412
Recruiting
This is a prospective observational study that will evaluate the association between bone and tissue perfusion, as measured by indocyanine green (ICG) fluorescence imaging, and complications, in an effort to develop ICG fluorescence imaging as a diagnostic tool to quantitatively guide operative debridement.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Trauma Injury
Register for Updates
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: University of California - Irvine Medical Center, Irvine, California
Conditions: Huntington's Disease
Register for Updates
Positive Affect Treatment for Adolescents With Early Life Adversity
NCT06273137
Recruiting
Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed adolescents in order to determine whether PAT increases positive affect, and subsequently symptoms of depression. For this pilot... Read More
Gender:
All
Ages:
Between 12 years and 16 years
Trial Updated:
02/25/2024
Locations: University of California Irvine, Irvine, California
Conditions: Depression
Register for Updates
Molecular Transducers of Physical Activity Consortium (MoTrPAC) - Pediatric Protocol
NCT04151199
Recruiting
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, studies will be conducted in adults and separately in children and adolescents. The UC Irvine MoTrPAC Pediatric Clinical Center oversees two interrelated study phases in children and adolescents: A cross-sectional phase in which molecular transducers (obtained from blood sampling) are measured in response to an acut... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
02/23/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Physical Activity
Register for Updates
Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma
NCT04744935
Recruiting
Optical coherence tomography guided laser treatment of basal cell carcinoma
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
02/22/2024
Locations: UCI Health Gottschalk Medical Plaza, Irvine, California
Conditions: Basal Cell Carcinoma, Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma
Register for Updates
Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-Line Treatment in Participants With PD-L1-Positive (CPS ≥ 1) Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
NCT05287113
Recruiting
The purpose of this study is to evaluate the safety and efficacy of the combination of retifanlimab plus INCAGN02385 and retifanlimab plus INCAGN02385 and INCAGN02390 compared with retifanlimab alone as first-line treatment in PD-L1-positive and systemic therapy-naive recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN).
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
02/22/2024
Locations: City of Hope Orange County, Irvine, California
Conditions: Head and Neck Cancer
Register for Updates
Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents
NCT03369691
Recruiting
The study will examine the mechanisms linking race, stress and biobehavioral factors to energy balance and obesity in both natural and controlled environments in African-American and Caucasian adolescent females. A Hispanic/Latina cohort has recently been added with permission for the sponsor.
Gender:
Female
Ages:
Between 13 years and 17 years
Trial Updated:
02/22/2024
Locations: Universty of California, Irvine, Irvine, California
Conditions: Obesity, Adolescent, Stress, Physical Activity
Register for Updates
Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
NCT03370393
Recruiting
Adolescence is a time of biological and behavioral changes that can lead to risky and dangerous behaviors, and African-American youth are highly vulnerable to the consequences of risky behavior, including HIV/AIDS and violence, leading to premature death. The investigators previously showed that an intervention program reduces HIV-risk vulnerability behaviors in many African-American youth. The investigators aim to measure how the program affects different regions of the brain in order to better... Read More
Gender:
All
Ages:
Between 11 years and 14 years
Trial Updated:
02/22/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Risk-Taking, Adolescent Behavior
Register for Updates