The state of California currently has 45 active clinical trials seeking participants for Autism research studies. These trials are conducted in various cities, including Los Angeles, San Francisco, San Diego and Sacramento.
Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth
NCT06362733
Recruiting
The purpose of this open label trial is to examine the preliminary feasibility, acceptability, and effectiveness of a 12-week behavioral intervention program (1 hour/week) to treat insistence on sameness (e.g., difficulty tolerating changes in routine) in youth with autism spectrum disorder (ASD). Treatment will be delivered via secure telemedicine platform and consist of a combination of parent-training and parent-mediated intervention with the child.
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
08/19/2025
Locations: 401 Quarry Road (Remote Study), Stanford, California
Conditions: Autism Spectrum Disorder, Restricted Behavior, Autism
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Trial of Zolpidem for Sleep in Children With Autism
NCT05540574
Recruiting
The purpose of this study is to examine the effect of zolpidem on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Zolpidem is a nonbenzodiazepine GABAa receptor agonist drug that acts as a hypnotic. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of zolpidem on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
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Trial of Diphenhydramine for Sleep in Children With Autism
NCT05501678
Recruiting
The purpose of this study is to examine the effect of diphenhydramine on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Diphenhydramine is an anti-histaminergic agent with strong hypnotic properties. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of diphenhydramine on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
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Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
NCT04532424
Recruiting
Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.
Gender:
ALL
Ages:
Between 12 years and 45 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism Spectrum Disorder, Autism, Asperger Syndrome
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Trial of Suvorexant for Sleep in Children With Autism
NCT05546554
Recruiting
The purpose of this study is to examine the effect of suvorexant on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Suvorexant is a selective, dual orexin receptor antagonist (DORA) used for the treatment of sleep onset difficulties and/or sleep maintenance. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of suvorexant on sleep physiology as assessed by polysomnography (PSG), ac... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
08/16/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
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School-based Paraeducator Education for Engagement at Recess
NCT06559267
Recruiting
The purpose of the proposed three-site study is to test whether an educator-level implementation strategy, coaching, with or without a school-level implementation strategy, school-based teams, will maximize paraeducators' use (fidelity and sustainment) of an evidence-based social engagement intervention, Remaking Recess (RR). RR aims to improve peer related social skills for autistic students and their non-autistic peers who are socially isolated or peripheral and need support during recess.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
08/11/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Autism Spectrum Disorder, Neurodevelopmental Disorders
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RCT to Evaluate Social Skills in Children With Autism Using VR Technology (SoCaVR)
NCT06453629
Recruiting
The goal of this randomized clinical trial is to compare and learn about Virtual Reality (VR) in children with autism/Autistic children. The main question it aims to answer is: • Does the Floreo VR clinical product show clinical improvement in autism symptoms? Participants will engage the VR product for twice a week for twelve weeks. They will be randomized to either the Floreo Clinical Product or a VR Control group experience. Researchers will compare the two groups to see if there is an e... Read More
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
08/04/2025
Locations: Cortica- Carlsbad, Carlsbad, California +7 locations
Conditions: Autism Spectrum Disorder, Social Communication
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Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
NCT06229210
Recruiting
This is a multicenter, global, 26-week, open-label study to assess the safety and tolerability of lumateperone in pediatric patients with schizophrenia, bipolar disorder or autism spectrum disorder.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
07/07/2025
Locations: Clinical Site, Anaheim, California +6 locations
Conditions: Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder
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Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients
NCT06706674
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients aged 5 to 17 years with a primary diagnosis of irritability associated with Autism Spectrum Disorder (ASD) based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Text Revision (DSM-5-TR) and confirmed by the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL).
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
07/03/2025
Locations: Clinical Site, Imperial, California +2 locations
Conditions: Irritability Associated With Autism Spectrum Disorder
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Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder in Pediatric Patients
NCT06690398
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients aged 5 to 17 years with a primary diagnosis of irritability associated with Autism Spectrum Disorder (ASD) based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Text Revision (DSM-5-TR) and confirmed by the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL).
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
07/02/2025
Locations: Clinical Site, Anaheim, California +6 locations
Conditions: Irritability Associated With Autism Spectrum Disorder
Register for Updates
ML-004 in Adolescents and Adults With Autism Spectrum Disorders (ASD)
NCT05081245
Recruiting
ML-004-002 is a multi-center, randomized, double-blind, parallel-group, placebo-controlled study that will enroll approximately 150 adolescent and adult subjects with ASD. The primary objective is to evaluate the efficacy of ML-004 compared with placebo in the improvement of social communication deficits in subjects with ASD.
Gender:
ALL
Ages:
Between 12 years and 45 years
Trial Updated:
06/18/2025
Locations: Cortica Healthcare, Glendale, California +5 locations
Conditions: Autism Spectrum Disorder
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International Multicentric Observational Study to Characterize Subpopulations of Patients With Autism Spectrum Disorder
NCT05590715
Recruiting
To determine sufficient number of biological and clinical markers to identify subgroups of potential best responders to a specific medication
Gender:
ALL
Ages:
Between 12 years and 65 years
Trial Updated:
06/16/2025
Locations: California Neuroscience Research, Sherman Oaks, California
Conditions: Autism Spectrum Disorder
Register for Updates