There are currently 320 clinical trials in Irvine, California looking for participants to engage in research studies. Trials are conducted at various facilities, including University of California, Irvine, Kaiser Permanente-Irvine, City of Hope at Irvine Lennar and UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of DF9001 in Patients With Advanced Solid Tumors
NCT05597839
Recruiting
DF9001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express epidermal growth factor receptor (EGFR). The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eligible pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: UC Irvine Medical Center, Irvine, California
Conditions: Solid Tumor, Adult
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Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis
NCT05526898
Recruiting
This is an multi-center study with the aim of evaluating the efficacy of adipose tissue processed with the SyntrFuge™ system in Orthopedic Surgery, specifically Knee Osteoarthritis. Patients will be enrolled to the treatment group with adipose tissue processed with the SyntrFuge™ system followed by an injection of autologous microsized adipose tissue in the treatment sites or Standard of Care.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/15/2024
Locations: Irvine Site 1, Irvine, California +1 locations
Conditions: Knee Osteoarthritis
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Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission
NCT05230173
Recruiting
The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ulcerative colitis \[UC\]) in symptomatic remission with moderate to severe endoscopic inflammation despite optimization of index TIM in a real-world setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Hoag Hospital, Irvine, California
Conditions: Ulcerative Colitis, Crohn Disease
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A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)
NCT05685433
Recruiting
A prospective, multicenter, single-arm study to evaluate the safety and effectiveness of the eCoin® implanted tibial nerve stimulator in subjects with urgency urinary incontinence (UUI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/06/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Overactive Bladder, Urge Incontinence, Incontinence, Urinary, Urinary Urge Incontinence
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Effect of VR on Pain and Patient Satisfaction in Adults Receiving GNRFA
NCT05468398
Recruiting
The study team aims to investigate whether implementing virtual reality therapy (VRT) during Genicular nerve radiofrequency ablation (GNRFA) procedure will provide better alleviation of procedural pain and augmented satisfaction for patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/29/2024
Locations: UC Irvine Gottschalk Medical Plaza, Irvine, California
Conditions: Pain, Patient Satisfaction
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I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
NCT04488081
Recruiting
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: UC Irvine Medical Center, Irvine, California
Conditions: COVID-19
Register for Updates
Assisted Fluid Management (AFM) System and Postoperative Outcome After High-risk Abdominal Surgery
NCT06011187
Recruiting
Goal directed fluid therapy (GDFT) or "Personalized fluid therapy" may benefit high-risk surgical patients but these strategies are infrequently implemented. It has also been shown that without any goal or protocol for fluid resuscitation, large inter- and intra-provider variability exist that have been correlated with poor patient outcomes. Recently, an "Assisted Fluid Management" (AFM) system has been developed to help ease some of the work associated with GDFT protocol implementation. The AF... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: University of California IRVINE, Irvine, California
Conditions: Decision Support System, Outcome
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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: University of California - Irvine Medical Center, Irvine, California
Conditions: Huntington's Disease
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Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma
NCT04744935
Recruiting
Optical coherence tomography guided laser treatment of basal cell carcinoma
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/22/2024
Locations: UCI Health Gottschalk Medical Plaza, Irvine, California
Conditions: Basal Cell Carcinoma, Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma
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Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target
NCT00842283
Recruiting
The researchers believe that pro-angiogenic factors are upregulated in a wide range of dermatologic diseases including port wine stains, hemangiomas, angiofibromas, Kaposi's sarcoma, angiosarcoma, scars, rosacea and psoriasis. The researcher can perform immunohistochemistry and/or microarray analysis and/or quantitative polymerase chain reaction on previously biopsied skin specimens and newly biopsied skin specimens to evaluate the expression of various angiogenic factors in these dermatologic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/27/2024
Locations: Gottschalk Medical Plaza, Irvine, California +1 locations
Conditions: Dermatologic Diseases
Register for Updates
Pro APP Prosthetic Outcome Registry
NCT06210620
Recruiting
A national, multi-center registry of patients using lower-limb prosthesis, their profiles and devices, and their long-term follow-up and clinical outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2024
Locations: Össur Americas, Irvine, California
Conditions: Amputation
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Coflex PS3 Actual Conditions for Use Study
NCT02555280
Recruiting
A 2 and 5 year evaluation of clinical outcomes in the treatment of degenerative spinal stenosis with concomitant low back pain by decompression with additional stabilization using the coflex® Interlaminar Technology for FDA Actual Conditions of Use Study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: Hoag Orthopedics, Irvine, California
Conditions: Spinal Stenosis Lumbar
Register for Updates