There are currently 782 clinical trials in San Diego, California looking for participants to engage in research studies. Trials are conducted at various facilities, including University of California, San Diego, Rady Children's Hospital San Diego, GSK Investigational Site and Naval Medical Center San Diego. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer
NCT05364645
Recruiting
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may st... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Kaiser Permanente-San Diego Zion, San Diego, California
Conditions: Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
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Low-Dose Intravenous Ketamine for Adolescents With Depression and Suicidal Ideation in the Emergency Department
NCT05217706
Recruiting
The goal of this study is to test whether a single low-dose of IV ketamine given in the emergency department to adolescents with treatment-resistant depression and suicidal ideation can reduce depression symptoms and suicidal thoughts compared to placebo. Participants will complete depression scales at baseline, and 1 hour, 3 hours, 1 day, 3 days, and 7 days after receiving the treatment.
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
02/15/2023
Locations: Rady Children's Hospital San Diego, San Diego, California
Conditions: Depression, Suicidal Ideation
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Effectiveness of AlloWrap® for the Reduction of Inflammation in ACDF Procedures
NCT04684901
Recruiting
The primary objective of this study is to obtain evidence of the effectiveness of AlloWrap Amniotic Membrane in the reduction of soft tissue swelling in two-level ACDF procedures.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/09/2023
Locations: Spine Institute of San Diego, San Diego, California
Conditions: Cervical Stenosis, Spondylolisthesis, Cervical Radiculopathy, Cervical Disc Disorder
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Prospective Pilot Feasibility Study Comparing Envarsus Once-a-day to Tacrolimus Twice-a-day Immunosuppressive Regimen on Drug Bioavailability in Hispanic First Time Kidney Transplant Recipients
NCT03438773
Recruiting
This investigator-initiated post-marketing study will evaluate the role of Hispanic ethnicity on drug dosing of Envarsus in first-time stable renal transplant recipients. Tacrolimus trough drug levels will be studied as a primary endpoint at 24 hours after drug dosing and at steady state (e.g., trough level at 3 months post conversion) and secondary compliance assessments will be done by pill counts at clinic visits. Secondary outcomes will be the safety of once a day dosing as well as assessmen... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/07/2023
Locations: California Institute of Renal Research, San Diego, California
Conditions: Kidney Transplant; Complications, Kidney Transplant Failure and Rejection
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Efficacy of mHealth Applications in Weight Management in a Population Affected by Overweight or Obesity
NCT05726942
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes in patients with overweight and obesity. This study will involve a 6-month long commitment where participants will be expected to use an mHealth app daily, weigh themselves and check their fasting blood glucose levels every morning.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
02/03/2023
Locations: San Diego State University, San Diego, California
Conditions: Overweight and Obesity
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Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation
NCT04950894
Recruiting
Multi-center, open-label, prospective, randomized clinical trial of the aura6000(R) System for the reduction of apnea and hypopneas in adult patients with moderate to severe obstructive sleep apnea who have failed or are unwilling to use positive airway pressure treatment.
Gender:
All
Ages:
22 years and above
Trial Updated:
02/02/2023
Locations: Paul Schalch Lepe, Md/Silenso Clinic, San Diego, California
Conditions: Obstructive Sleep Apnea, OSA, Apnea, Apnea, Obstructive, Apnea, Obstructive Sleep, Apnea+Hypopnea, Hypopnea, Sleep
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ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK
NCT03287271
Recruiting
The purpose of the study is to investigate the combination VS-6063, carboplatin, and paclitaxel. in the treatment of patients with ovarian cancer. The study will evaluate whether this regimen is safe. The study will also evaluate whether the regimen can reduce the amount of cancerous cells in your body. If you agree, you will be treated with VS-6063 by mouth, as well as carboplatin and paclitaxel infusions. Carboplatin and paclitaxel are approved by the FDA for the treatment of ovarian cancer. V... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: University of California San Diego, San Diego, California
Conditions: Ovarian Cancer
Register for Updates
Collection of Samples USOPTIVAL Study
NCT04792684
Recruiting
A prospective multi-center observational study. The study will enroll eligible subjects from the United States to optimize the biomarker panel and evaluate the performance of a cfDNA marker panel selected by the Sponsor for CRC and advanced adenoma detection.
Gender:
All
Ages:
Between 45 years and 84 years
Trial Updated:
01/26/2023
Locations: Precision Research Institute, San Diego, California +1 locations
Conditions: Colorectal Cancer (CRC), Advanced Adenomas (AA)
Register for Updates
Study of the Safety and Efficacy of STI-6643 in Subjects With Advanced Solid Tumors
NCT04900519
Recruiting
This is a first-in-human, phase 1, open-label, dose-escalation study of STI-6643 administered by intravenous infusion in subjects with a relapsed/refractory advanced solid tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2023
Locations: University of California, San Diego, San Diego, California
Conditions: Solid Tumor, Relapsed Solid Neoplasm, Refractory Tumor
Register for Updates
Effect of Myofunctional Therapy on OSA
NCT04608552
Recruiting
The primary medical therapies for patients with Obstructive Sleep Apnea syndrome (OSA) require the use of medical devices on a nightly basis to help control breathing during sleep, which can be difficult for patients with mild-to-moderate disease. Because many patients use these therapies on a limited basis, or stop using them altogether, they continue to be at increased risk of the consequences of untreated OSA. Untreated and undertreated OSA compounds the risk of OSA consequences over time, pa... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/09/2023
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Obstructive Sleep Apnea
Register for Updates
Identification of Patients With a High Probability of Meeting Eligibility Criteria for an Alzheimer's Disease Clinical Trial (APHELEIA)
NCT05364307
Recruiting
Apheleia-001 is a prescreener that aims to identify and characterize participants with reported cognitive impairment using demographic information, clinical history, brief cognitive assessments, and blood-based biomarkers to distinguish appropriate participants for referral to a therapeutic AD clinical trial.
Gender:
All
Ages:
Between 50 years and 90 years
Trial Updated:
12/28/2022
Locations: Pacific Research Network, San Diego, California
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Memory Loss, Memory Disorders, Memory Impairment
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Mobile Biosensor for Measuring Vital Signs in Healthcare and Home Settings
NCT04233827
Recruiting
This study will record vital signs (heart rate and blood oxygen levels) using a new cell phone integrated biosensor and compare it to routine measurements carried out in the clinics and hospital at UCSD. Cell phones will be given to a selected group of subjects for use at home and data collected.
Gender:
All
Ages:
13 years and above
Trial Updated:
12/21/2022
Locations: UCSD AntiViral Research Center, San Diego, California
Conditions: Pulse Oximetry
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