The city of Aurora, Colorado, currently has 171 active clinical trials seeking participants for Cancer research studies.
Carboplatin or Olaparib for BRcA Deficient Prostate Cancer
Recruiting
This is an unblinded, randomized clinical study comparing the efficacy of DNA damaging chemotherapy using carboplatin, to standard of care therapy for patients who have metastatic castrate resistant prostate cancer. This trial will use olaparib or carboplatin as initial therapy with crossover to the alternate or second-line drug after first progression for patients with tumors containing BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D, or RAD54L inactivating mutations. P... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
10/31/2023
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado
Conditions: Metastatic Castrate Resistant Prostate Cancer, BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D, or RAD54L Mutations
CNS Qualitative Interview
Recruiting
Explore factors involved in decision making for patients with new or recurrent CNS tumors and their families surrounding treatment planning and clinical trial enrollment.
Gender:
All
Ages:
All
Trial Updated:
10/25/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Central Nervous System Cancer
Pediatric Oncology Recovery Trial After Surgery
Recruiting
Pediatric Oncologic Recovery Trial After Surgery (PORTS) trial is an investigator-initiated, multicenter, multidisciplinary prospective case-control study of the implementation of an Enhanced Recovery After Surgery (ERAS) protocol at five tertiary-care pediatric hospitals in pediatric patients undergoing abdominal or retroperitoneal surgical resections for cancer. A pilot phase will determine characteristics of a successful protocol implementation and an exploratory phase plans to examine adhere... Read More
Gender:
All
Ages:
Between 1 month and 18 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Pelvic Cancer
Informational Meetings for Planning and Coordinating Treatment
Recruiting
This prospective cluster-randomized trial examines the efficacy of a novel communication intervention delivered by trained physician and nurse dyads to parents of children with cancer within the clinicians' practice, to foster alignment of the goals of treatment. The investigators hypothesize that goal alignment will improve quality of life outcomes, in particular for those patients who reach end of life. Findings from the proposed research will provide essential information to promote communica... Read More
Gender:
All
Ages:
Between 1 month and 17 years
Trial Updated:
10/01/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: End of Life, Communication, Cancer Metastatic
Care Planning Framework in Advanced Cancer (ABC123)
Recruiting
Pilot study assessing the feasibility and acceptability of the ABC123 framework, as well as goal concordance between patient and clinician stated goals. Patients >60 years old with recently diagnosed advanced, incurable cancer in for a first consultation at a participating medical oncology clinic. The team will pilot test the ABC123 framework delivery by an advanced practice provider working with a medical oncologist to inform the overall care planning process. This framework will routinely inco... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
09/19/2023
Locations: University of Colorado Cancer Center, Aurora, Colorado
Conditions: Advanced Cancer
Comparison of Contrast Agents in Liver MR for the Detection of Hepatic Metastases
Recruiting
If an abbreviated HBP protocol liver MR with gadobenate dimeglumine is shown clinically comparable to standard of care liver MR with gadoxetate disodium for detecting hepatic metastasis from colorectal cancer, its use will save time, cost, and patients' effort.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/11/2023
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Oligometastatic Disease, Liver Metastases, Colorectal Cancer
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
Recruiting
This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma. The usual approach for patients is treatment with FOLFOX chemotherapy. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by k... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/30/2023
Locations: Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado
Conditions: Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma, Clinical Stage III Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Gastric Cancer AJCC v8, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IV Esophageal Adenocarcinoma AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Metastatic Esophageal Adenocarcinoma, Metastatic Gastric Adenocarcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Unresectable Esophageal Adenocarcinoma, Unresectable Gastric Adenocarcinoma, Unresectable Gastroesophageal Junction Adenocarcinoma
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
Recruiting
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/28/2023
Locations: Rocky Mountain Regional VA Medical Center, Aurora, Colorado +1 locations
Conditions: Previously Treated Non-Small Cell Lung Cancer
Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children
Recruiting
The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.
Gender:
All
Ages:
Between 5 years and 10 years
Trial Updated:
08/21/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Survivors of Childhood Cancer, Bladder Dysfunction
Biomarkers of Immune-Related Toxicity
Recruiting
This is a single-center, correlative pilot study evaluating potential biomarkers predictive of immune-related adverse events associated with immune checkpoint inhibitor therapy.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
08/21/2023
Locations: University of Colorado Denver, Aurora, Colorado
Conditions: Cancer, Metastatic Cancer
Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer
Recruiting
The overall objective of this study is to develop a novel couple-based mindfulness intervention aimed at reducing distress in patients with metastatic colorectal cancer (mCRC) and their partners.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/18/2023
Locations: University of Colorado Cancer Center, Aurora, Colorado
Conditions: Metastatic Colorectal Cancer
High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers
Recruiting
This study will determine whether the presence of DNA repair deficiency in the form of alterations in the genes ATM, CDK12 or CHEK2 predicts for a high likelihood of responding to the use of intermittent high dose testosterone. This therapy may result in responses in tumors which are genetically unstable because of DNA repair deficiency and this is a prospective study to test that hypothesis
Gender:
Male
Ages:
18 years and above
Trial Updated:
08/16/2023
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado
Conditions: Metastatic Prostate Cancer