The city of Aurora, Colorado, currently has 17 active clinical trials seeking participants for Parkinson's Disease research studies.
Slow Wave Sleep as a Biomarker of Rehabilitation-induced Cognitive Improvement in PD
Recruiting
The purpose of this study is to investigate the effects of exercise rehabilitation on cognition and to evaluate slow wave sleep (SWS) as a biomarker and mediator of response to rehabilitation-induced improvement in cognitive performance among persons with Parkinson's disease (PwP), with the ultimate goal of maximizing rehabilitation efficacy at the individual level (i.e. precision rehabilitation).
Gender:
All
Ages:
Between 45 years and 100 years
Trial Updated:
06/19/2024
Locations: University of Colorado, Anschutz Medical Campus, Aurora, Colorado
Conditions: Parkinson Disease
Parkinson's Disease Progression Study
Recruiting
Disease Progression Study
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/18/2024
Locations: University of Colorado Health Neurosciences Center, Aurora, Colorado
Conditions: Parkinson Disease
Use of CereGate Therapy for Freezing of Gait in PD
Recruiting
A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.
Gender:
All
Ages:
Between 21 years and 75 years
Trial Updated:
06/14/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
Recruiting
The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific's commercially available Vercise DBS System in the treatment of Parkinson's disease. The utilization of Image Guided Programming (IGP), and other commercially available programming features, used as planning tools for the programming of patients with Boston Scientific's Vercise DBS System are also evaluated. Additionally, the utilization of the DBS Illumina 3D feature that may be... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/11/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Parkinson's Disease
Evaluation of a Decision Aid for Deep Brain Stimulation Surgery for Parkinson's Disease
Recruiting
The goal of this clinical trial is to learn if a Decision Aid can help patients with Parkinson's disease make a decision about undergoing Deep Brain Stimulation surgery. The main questions it aims to answer are: Is the Decision Aid acceptable to patients with Parkinson's disease considering Deep Brain Stimulation surgery? Does the decision aid improve decision quality (informed, value-based decision) and uncertainty about the decision? Researchers will compare immediate use of the decision aid... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: University of Colorado Anschutz, Aurora, Colorado
Conditions: Parkinson Disease
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
Recruiting
The purpose of this randomized, double-blind, placebo-controlled study is to assess the efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over 78 weeks in subjects with Parkinson's disease who have a pathogenic variant in the glucocerebrosidase 1 (GBA1) gene (GBA-PD).
Gender:
All
Ages:
Between 35 years and 80 years
Trial Updated:
05/29/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Parkinson's Disease
Study in Parkinson Disease of Exercise
Recruiting
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 mon... Read More
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
05/29/2024
Locations: University of Colorado, Denver, Aurora, Colorado
Conditions: Parkinson Disease
A Study of Suvecaltamide in Adults With Moderate to Severe Residual Tremor in Parkinson's Disease
Recruiting
This is a 17-week double-blind, placebo-controlled, randomized, flexible-dosing, parallel-group, multicenter study designed to evaluate the efficacy and safety of suvecaltamide for the treatment of moderate to severe residual tremor in adult participants with Parkinson's disease (PD). The target population represents participants who have tremor that is not adequately controlled by PD medications and that interferes with their activities of daily living (ADL) and/or with their performance of tas... Read More
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
04/29/2024
Locations: University of Colorado Hospital Anschutz Outpatient Pavilion, Aurora, Colorado
Conditions: Parkinson Disease, Tremor
A Study to Assess the Safety of BIIB122 Tablets and if it Can Slow the Worsening of Early-Stage Parkinson's Disease in Participants Between the Ages of 30 and 80
Recruiting
In this study, researchers will learn more about a study drug called BIIB122 in participants with early-stage Parkinson's disease (PD). In this study: Participants will take 225 milligrams (mg) of BIIB122 or a placebo as tablets by mouth. A placebo looks like the study drug but has no real medicine in it. Participants will take BIIB122 or placebo 1 time a day for up to a minimum of 48 weeks and a maximum of 144 weeks. Certain medications for PD will be allowed at enrollment for a subset of part... Read More
Gender:
All
Ages:
Between 30 years and 80 years
Trial Updated:
04/17/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Parkinson Disease
Low-load Resistance Training With Blood Flow Restriction in People With Parkinson's Disease
Recruiting
The study's objective is to determine the feasibility of low-load resistance training with blood flow restriction in people who have advanced Parkinson's disease and impaired mobility using a mixed-methods convergent parallel design in a single cohort. The study's long-term goal is to develop clinically feasible exercise interventions that are effective at improving mobility, participation, and quality of life for people with advanced Parkinson's disease.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
03/27/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Parkinson Disease
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
Recruiting
Patients with Parkinson's disease (PD) sometimes experience symptoms affecting their movement, such as slowness, tremor, stiffness, and balance or walking problems. Many patients also have other symptoms not related to movement, called non-motor symptoms, which may affect one's mood or emotions, memory or thinking, or cause one to see or hear things that aren't real (hallucinations) or believe things that aren't true (delusions). Hallucinations or delusions, together called psychosis, occur in u... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
02/08/2024
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado
Conditions: Parkinson's Disease Psychosis
NMT for Parkinson's Disease
Recruiting
Parkinson's Disease (PD) is defined by characteristic motor symptoms including slow movements, small movements, difficulty with movement initiation and disruptions in timing. Besides gross motor symptoms, fine motor impairments in PD cause difficulties with everyday tasks such as writing, self-care, and fine object manipulation. These activity limitations can lead to disability, social isolation, and a reduced quality of life. In a series of breakthrough studies Michael Thaut and colleagues deve... Read More
Gender:
All
Ages:
Between 45 years and 85 years
Trial Updated:
01/02/2024
Locations: University of Colorado Denver, Aurora, Colorado
Conditions: Parkinson Disease