The state of Colorado currently has 12 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Denver, Aurora, Colorado Springs and Englewood.
BPL-003 Efficacy and Safety in Treatment Resistant Depression
Recruiting
This is a Phase 2 study randomized, quadruple masked, multi-center study designed to investigate the efficacy and safety of a single dose of BPL-003 combined with psychological support in patients with treatment resistant depression (TRD).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/19/2024
Locations: Wholeness Center, Fort Collins, Colorado
Conditions: Treatment Resistant Depression
Examining the Efficacy of a Digital Therapeutic to Prevent Suicidal Behaviors
Recruiting
The primary aim of the project is to test the efficacy of BCBT delivered via a digital platform (i.e., smartphone) to Servicemembers with recent suicidal ideation and/or suicide attempts presenting to primary care clinics. Given existing challenges of scaling empirically-supported treatments/interventions for suicidality with fidelity, this project could lead to markedly expanded access to BCBT, along with improving our understanding about what intervention strategies are most effective and how... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Fort Carson, Colorado Springs, Colorado
Conditions: Suicidal Behaviors, Suicide Ideation, Depression/Anxiety
A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)
Recruiting
This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/15/2024
Locations: Relmada Site, Denver, Colorado
Conditions: Major Depressive Disorder, Depression
Depression & Insulin Sensitivity in Adolescents
Recruiting
There has been a rise in type 2 diabetes (T2D) rates in adolescents, disproportionately in girls from disadvantaged racial/ethnic groups. This group of girls also is at heightened risk for depression, and depression and T2D are linked. Depressive symptoms are a risk factor for worsening of insulin sensitivity, one if the major precursors to T2D. In preliminary studies, the investigators found that a brief cognitive-behavioral therapy group decreased depressive symptoms and prevented worsening of... Read More
Gender:
Female
Ages:
Between 12 years and 17 years
Trial Updated:
12/06/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance, Depression, Adolescent Obesity
Parenting Skills Group for Mothers With Postpartum Depression
Recruiting
The goal of this longitudinal study is to study the effects of a parenting skills group (Circle of Security Parenting, aka COSP) in mothers with postpartum depression. The main questions it aims to answer are: Will changes in methylation of the OXTR rs53576 be apparent in mother and/or infant after having gone through the 8-week COSP program? Will COSP participation be associated with improved symptoms of postpartum depression (over and above standard care), attachment style, and relational cha... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
11/28/2023
Locations: University of Colorado Denver, Denver, Colorado
Conditions: Postpartum Depression
Companion Dog Walking for ICU Survivor Health
Recruiting
The goal of this clinical trial is to determine the feasibility and acceptability of a randomized controlled trial comparing a pet dog walking intervention to an attention control education intervention in adult intensive care unit survivors. The main question[s] it aims to answer are: What is the feasibility of a pet dog-walking intervention compared to an attention control education intervention on depression, anxiety, cortisol, and quality of life for adult ICU survivors. What is the accept... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Penrose Hospital, Colorado Springs, Colorado +1 locations
Conditions: Post Intensive Care Syndrome, Depression, Anxiety, Quality of Life
Modulating Exercise Dosage to Improve Concussion Recovery
Recruiting
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity l... Read More
Gender:
All
Ages:
Between 13 years and 18 years
Trial Updated:
10/18/2023
Locations: University of Colorado Denver, Aurora, Colorado
Conditions: Concussion, Brain, Treatment, Aerobic Exercise, Inflammation, Depression, Anxiety
Creative Arts Program to Reduce Burnout in Healthcare Professionals
Recruiting
This study plans to learn if creative arts programs that include visual, musical, written, or physical expression can reduce symptoms of burnout syndrome, Post Traumatic Stress Disorder (PTSD), depression, and anxiety in critical care healthcare professionals. This study also explores if creative arts can enhance the connection to the purpose of work, the development of adequate coping skills, while providing time to connect with peers.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/12/2023
Locations: University of Colorado - Anschutz Medical Campus, Aurora, Colorado
Conditions: Burn-Out Syndrome, Post-Traumatic Stress Disorder, Depression, Anxiety
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Recruiting
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise training groups, decreases stress, improves mood, increases physical activity and physical fitness, and decreases insulin resistance among teenagers at risk for diabetes.
Gender:
Female
Ages:
Between 12 years and 17 years
Trial Updated:
06/15/2023
Locations: Children's Hospital Colorado, Aurora, Colorado +1 locations
Conditions: Insulin Resistance, Depression, Depressive Disorder, Mood Disorders, Mental Disorder in Adolescence, Hyperinsulinism, Glucose Metabolism Disorders, Metabolic Disease
In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression
Recruiting
The goal of this clinical trial is to test whether an established preventive intervention (group interpersonal therapy) delivered virtually shows the same benefits for preventing postpartum depression as it does when delivered in person.
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: Denver Health Medical Center, Denver, Colorado
Conditions: Postpartum Depression
Heartfulness Meditation to Improve Resilience Among Health Care Students: A 90 Day Program
Recruiting
This investigation will examine the feasibility of delivery and effect on resilience, depression and anxiety of a 90-day Heartfulness Practice delivered virtually for health care students. It is hypothesized that by providing this program on-line, students will be able to attend easily and complete the sessions. It is also hypothesized that those students who participate in the meditation program will increase resilience.
Gender:
All
Ages:
Between 20 years and 70 years
Trial Updated:
08/12/2022
Locations: University of Colorado Anschutz, Aurora, Colorado
Conditions: Mental Health Wellness 1, Stress, Psychological, Depression, Anxiety
Randomized Clinical Trial of a Multi-Modal Palliative Care Intervention
Recruiting
Adults diagnosed with metastatic cancer commonly experience depression and anxiety symptoms, which can interfere with advance care planning. This randomized clinical trial evaluates a novel, piloted, primary palliative care intervention that addresses advance care planning and psychosocial needs of patients with metastatic cancer. The intervention focuses on patients with elevated anxiety and depression (anx/dep) symptoms-those with highest psychosocial needs who may be at greatest risk for adva... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/25/2022
Locations: Rocky Mountain Cancer Centers, Boulder, Colorado
Conditions: Depression, Anxiety, Metastatic Cancer