There are currently 6 active clinical trials seeking participants for Cocaine Dependence research studies. The states with the highest number of trials for Autism participants are Texas, Connecticut, Pennsylvania and New York.
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
Recruiting
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2023
Locations: UVA Center for Leading Edge Addiction Research, Charlottesville, Virginia
Conditions: Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Recruiting
Background: More effective treatments for people with cocaine use disorder are needed. Researchers want to understand the parts of the brain involved in the disorder. Transcranial magnetic stimulation (TMS) stimulates parts of the brain. A form of TMS called intermittent theta-burst stimulation (iTBS) may help reduce cocaine use. Researchers want to learn how the brain might change with treatment. Objectives: To test if iTBS can reduce cocaine use. Also, to learn how cocaine changes the heart... Read More
Gender:
All
Ages:
Between 22 years and 60 years
Trial Updated:
03/26/2024
Locations: National Institute on Drug Abuse, Baltimore, Maryland
Conditions: Cocaine Use Disorder, Cocaine Dependence
Substance Abuse Pre-Treatment Screening Study
Recruiting
The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for their presenting concerns or interests. A second purpose is to have a consolidated intake data base on which secondary analyses can be conducted.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
12/19/2023
Locations: University of Texas Medical School- Houston, Dept. of Psychiatry Mental Sciences Institute, Houston, Texas
Conditions: Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence, Substance Abuse
Safety Study of a Disrupted Adenovirus (Ad) Serotype Cocaine Vaccine for Cocaine-dependent Individuals
Recruiting
The purpose of this study is to assess the safety and preliminary efficacy of an anti-cocaine vaccine called dAd5GNE in cocaine-dependent individuals. It uses the concept of a vaccine to treat the neurological effects of cocaine by evoking "immunity" to prevent the effects of cocaine on the brain.
Gender:
All
Ages:
Between 21 years and 69 years
Trial Updated:
12/13/2023
Locations: WCMC Department of Genetic Medicine, New York, New York
Conditions: Cocaine Dependence
Clavulanic Acid for the Treatment of Cocaine Use Disorder
Recruiting
A dose escalation study to assess the efficacy and safety of Clavulanic Acid (CLAV) vs. placebo (PBO) for the treatment of cocaine use disorder (CUD)
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/02/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +1 locations
Conditions: Cocaine Dependence
tDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study
Recruiting
Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation in which low level electrical currents are applied to the scalp in order to alter brain function. In a prior Phase-I study, the research team demonstrated feasibility of self-administration of a home-tDCS prototype in 14 patients that applied 15 sessions for each patient at an outpatient center.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
08/13/2021
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Cocaine Use Disorder, Cocaine Dependence