There are currently 54 active clinical trials seeking participants for Diabetes Mellitus research studies. The states with the highest number of trials for Diabetes Mellitus participants are California, Florida, Texas and North Carolina.
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
NCT03622359
Recruiting
The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging tool for quantifying regional abnormalities... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Diabetes Mellitus, Peripheral Artery Disease, Chronic Limb-Threatening Ischemia
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Impact of Per Oral Pyloromyotomy (POP) on Glycemic Control in Diabetes
NCT04696159
Recruiting
This study will assess changes in glycemic control in 40 patients with diabetes who undergo per-oral pyloromyotomy (POP) for medically refractory gastroparesis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Diabetes Mellitus, Gastroparesis With Diabetes Mellitus, Gastroparesis
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Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation
NCT03995238
Recruiting
The population of older Veterans with non-traumatic lower limb amputation is growing. Following lower limb amputation, asymmetrical movements persist during walking and likely contribute to disabling sequelae including secondary pain conditions, poor gait efficiency, impaired physical function, and compromised skin integrity of the residual limb. This study seeks to address chronic gait asymmetry by evaluating the efficacy of two error-manipulation gait training programs to improve gait symmetry... Read More
Gender:
ALL
Ages:
Between 40 years and 89 years
Trial Updated:
04/15/2025
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado +1 locations
Conditions: Transtibial Amputation, Peripheral Artery Disease, Diabetes Mellitus
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Genetic Studies of Insulin and Diabetes
NCT00001987
Recruiting
The study will allow researchers to obtain blood, plasma, DNA, and RNA for genetic studies of insulin. There will be a focus on the causes of insulin resistance and diabetes mellitus. Insulin is a hormone found in the body that controls the level of sugar in the blood. Insulin resistance refers to conditions like diabetes when insulin does not work properly. In this study researchers would like to compare patients with diabetes and other forms of insulin resistance to normal individuals. The stu... Read More
Gender:
ALL
Ages:
Between 6 months and 120 years
Trial Updated:
04/11/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Diabetes Mellitus, Severe Insulin Resistance
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Early Tracking of Childhood Health Determinants (ETCHED) Study
NCT03481829
Recruiting
Background: Children s weight has increased sharply in recent years. This may put them at higher risk for health problems. High blood glucose in a pregnant mother and too much weight gain during pregnancy also may have long-term effects on the child s health. Children who become overweight or obese during childhood tend to remain so as adults. Researchers want to study many risk factors during and after pregnancy, and how these affect a child s development. They will also follow the mother s he... Read More
Gender:
ALL
Ages:
Between 1 day and 99 years
Trial Updated:
04/11/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Fatty Liver, Diabetes Mellitus
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Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis Associated Diabetes Mellitus
NCT06729996
Recruiting
The purpose of this study is to evaluate efficacy of pioglitazone (PIO) versus empagliflozin (EMPA) to improve glycemic control in people with Chronic Pancreatitis (CP) or Recurrent Acute Pancreatitis (RAP) associated with Diabetes Mellitus (DM). To evaluate mixed meal response in PIO versus EMPA group to better understand physiology of both therapies in CP-DM.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/10/2025
Locations: Mayo Clinic, Rochester, Minnesota +1 locations
Conditions: Pancreatitis, Chronic, Pancreatitis, Acute, Diabetes Mellitus
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Inflammation, Diabetes, Ethnicity and Obesity Cohort
NCT03022682
Recruiting
Obesity affects over one third of US adults (\>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given its prevalence, impact on morbidity and mortality, and economic cost, limiting the spread of obesity and its consequences is one of the mo... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/02/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Obesity, Diabetes Mellitus, Pre Diabetes
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Comparing Healthcare Visit Recording and Open Notes to Improve Chronic iLlness Care Experience in Older Adults
NCT05955339
Recruiting
CHRONICLE is a randomized trial assessing the comparative effectiveness of providing written visit information via the patient portal (NOTES) versus NOTES plus visit audio recording (AUDIO) to older adult patients with chronic diseases on quality of life and other outcomes. During the trial, the team will also invite caregivers identified by patients to join the project.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Dartmouth Hitchcock Clinics Manchester, Manchester, New Hampshire +2 locations
Conditions: Diabetes Mellitus, Hypertension
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A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer
NCT06623396
Recruiting
Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory at Memorial Sloan Kettering to be changed (modified) to become MSLN-targeted CAR T cells, the CAR T-cell therapy that participants will receive during the study. Participant study therapy will take about 3-4 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Mesothelin Positive, Mesothelin-Expressing Tumors, Esophageal Adenocarcinoma, Esophageal Adenocarcinomas, Esophagogastric Adenocarcinoma, Peritoneal Carcinomatosis, Breast Neoplasms, Diabetes Mellitus
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SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674
Recruiting
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be collected from eligible subjects previously treated in the SPYRAL PIVOTAL-SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama +97 locations
Conditions: Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
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American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
NCT04185844
Recruiting
Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key risk factors for these diseases remain unanswered in the AI population. To address this burden of CKD in AI communities Investigators formed a consortium of investigators with extensive experience in conducting research of chronic diseases including diabetes, cardiovascula... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
03/24/2025
Locations: NIDDK-Phoenix Epidemiology and Clinical Research, Phoenix, Arizona +2 locations
Conditions: Diabetes Mellitus, Chronic Kidney Diseases, Heart Diseases, Cardiovascular Diseases
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Family Investigation of Nephropathy and Diabetes (F.I.N.D.)
NCT00342927
Recruiting
The Family Investigation of Nephropathy and Diabetes (FIND) is a multicenter study designed to identify genetic determinants of diabetic kidney disease. FIND will be conducted in eleven centers and in many ethnic groups throughout the United States. Two different strategies will be used to localize genes predisposing to kidney disease: a family-based genetic linkage study and a case-control study that utilizes admixture linkage disequilibrium. The center based at the Phoenix office of the Nation... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/13/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Diabetic Nephropathy, Diabetes Mellitus, Diabetic Kidney Disease, Albuminuria
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