There are currently 33 active clinical trials seeking participants for Down Syndrome research studies. The states with the highest number of trials for Down Syndrome participants are California, Florida, Texas and Michigan.
Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome
NCT05059041
Recruiting
Individuals with Down syndrome (DS) live with visual deficits due, in part, to elevated levels of higher-order optical aberrations (HOA). HOAs are distortions/abnormalities in the structure of the refractive components of the eye (i.e. the cornea and the lens) that, if present, can result in poor quality focus on the retina, thus negatively impacting vision. HOAs in the general population are overall low, and thus not ordinarily considered during the eye examination and determination of refracti... Read More
Gender:
All
Ages:
5 years and above
Trial Updated:
05/02/2024
Locations: Ohio State University, Columbus, Ohio +1 locations
Conditions: Down Syndrome, Refractive Errors
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A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
NCT03914625
Recruiting
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexa... Read More
Gender:
All
Ages:
Between 365 days and 31 years
Trial Updated:
06/21/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +227 locations
Conditions: B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Down Syndrome
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Role of Early Motor Experience in Infants With Down Syndrome
NCT05144373
Recruiting
Infants with Down syndrome show significant delays and weaknesses in motor, cognitive, and language development compared to typically developing infants. This project aims to examine the developmental cascade effects of specific gross and fine motor experience on motor, cognitive and language development in infants with Down syndrome. We propose that both gross and fine motor experience will facilitate cognitive and language development in infants with Down syndrome, and particularly, fine motor... Read More
Gender:
All
Ages:
Between 7 months and 24 months
Trial Updated:
06/10/2024
Locations: Biomechanics lab, Atlanta, Georgia
Conditions: Down Syndrome
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DS-Connect {TM}: The Down Syndrome Registry
NCT01950624
Recruiting
Objective: The development of a patient registry for Down syndrome (DS) was identified as a priority in the 2007 Down Syndrome Research Plan. Under the auspices of the Down Syndrome Consortium, founded in 2011 as a public-private partnership between the NIH and DS advocacy organizations, NICHD awarded a contract in 2012 to create a patient-focused online registry to facilitate research participation by individuals with DS. Two advisory boards, composed of advocates, family members, clinicians, r... Read More
Gender:
All
Ages:
Between 3 months and 106 years
Trial Updated:
06/08/2024
Locations: National Institute of Child Health and Human Development (NICHD), 9000 Rockville, Bethesda, Maryland
Conditions: Down Syndrome
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Proactive Speech and Language Intervention for Infants With Down Syndrome
NCT06450509
Recruiting
Children with Down syndrome (DS) face life-long struggles with verbal communication. Babble and speech sound development is delayed, and speech can be difficult to understand. Words emerge late, at 21 months on average, compared to 12 months for typical peers, and vocabulary and grammar can remain limited throughout adulthood. Because DS is diagnosed at or even before birth, these difficulties are predictable; yet despite this prognostic knowledge, systematic and sustained proactive intervention... Read More
Gender:
All
Ages:
Between 0 months and 12 months
Trial Updated:
06/06/2024
Locations: Arizona State University, Tempe, Arizona
Conditions: Down Syndrome
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Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory and That Expresses E-selectin Ligand on the Cell Membrane
NCT05146739
Recruiting
This phase I trial tests the safety, side effects, and best dose of uproleselan in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia, myelodysplastic syndrome or mixed phenotype acute leukemia that has come back (relapsed) or does not respond to treatment (refractory) and that expresses E-selectin ligand on the cell membrane. Uproleselan binds to E-selectin expressed on endothelial cells of the bone marrow and prevents their interaction with selectin-E... Read More
Gender:
All
Ages:
17 years and below
Trial Updated:
06/04/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +18 locations
Conditions: Down Syndrome, Recurrent Acute Myeloid Leukemia, Recurrent Mixed Phenotype Acute Leukemia, Recurrent Myelodysplastic Syndrome, Refractory Acute Myeloid Leukemia, Refractory Mixed Phenotype Acute Leukemia, Refractory Myelodysplastic Syndrome, Acute Myeloid Leukemia Post Cytotoxic Therapy, Myelodysplastic Syndrome Post Cytotoxic Therapy
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Investigating the Impact of JASPER Behavioral Therapy in Children With Down Syndrome
NCT05638412
Recruiting
In this study, investigators will study the impact of a 1:1 caregiver coaching intervention using the JASPER (Joint Attention, Symbolic Play, Engagement, Regulation) behavioral therapy curriculum compared to a psychoeducational curriculum that will be provided to caregivers for self-directed learning. Investigators want to determine the impact of both interventions on the child's development and behavior, and caregiver implementation of strategies.
Gender:
All
Ages:
Between 36 months and 90 months
Trial Updated:
05/30/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Down Syndrome
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A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
NCT05702645
Recruiting
This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By learning more about the factors that may contribute to chronic health conditions and long-term effects after treatment for leukemia in persons with Down syndrome, clinical practice guidelines for survi... Read More
Gender:
All
Ages:
Between 6 years and 39 years
Trial Updated:
05/29/2024
Locations: Valley Children's Hospital, Madera, California +37 locations
Conditions: Down Syndrome, B Acute Lymphoblastic Leukemia Associated With Down Syndrome, Myeloid Leukemia Associated With Down Syndrome
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Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
NCT04801771
Recruiting
This study is a prospective, single-arm study conducted under a common implant and follow-up protocol. The objective will be to follow fifty-seven (57) adolescents and young adults (10-21 years of age), with Down syndrome, moderate to severe sleep apnea, and post-adenotonsillectomy, for 12 months after undergoing implant of the Inspire Upper Airway Stimulation (UAS) System. The study is being conducted in order to evaluate objective change in cognition and expressive language after implant and t... Read More
Gender:
All
Ages:
Between 10 years and 21 years
Trial Updated:
04/19/2024
Locations: Children's Healthcare of Atlanta/ Emory University School of Medicine, Atlanta, Georgia +7 locations
Conditions: Down Syndrome, Obstructive Sleep Apnea
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PAP for Children With DS and OSAS
NCT04132999
Recruiting
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
Gender:
All
Ages:
Between 6 years and 18 years
Trial Updated:
04/12/2024
Locations: University of Miami, Miami, Florida +2 locations
Conditions: Down Syndrome, Obstructive Sleep Apnea
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The Crnic Institute Human Trisome Project Biobank
NCT02864108
Recruiting
The Human Trisome Project will significantly increase the speed of Down syndrome research and the understanding of associated medical conditions. Its biobank will provide de-identified samples to research.
Gender:
All
Ages:
Between 6 months and 89 years
Trial Updated:
04/01/2024
Locations: Linda Crnic Institute for Down Syndrome at the University of Colorado Denver, Denver, Colorado
Conditions: Down Syndrome, Trisomy 21
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Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
NCT02612376
Recruiting
This study plans to establish a large bank of blood, cerebral spinal fluid (CSF), imaging, and clinical data. These data and samples will be used for future research into the causes of Alzheimer's disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems. This future research will also study how treatments for these diseases work. This research may help develop new treatments for some diseases of the nervous system and help understand these diseases better.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/29/2024
Locations: University of Colorado, Denver, Aurora, Colorado
Conditions: Alzheimer Disease, Down Syndrome, Mild Cognitive Impairment
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