There are currently 29 active clinical trials seeking participants for Down Syndrome research studies. The states with the highest number of trials for Down Syndrome participants are California, Florida, Texas and Michigan.
PAP for Children With DS and OSAS
NCT04132999
Recruiting
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
08/11/2025
Locations: University of Miami, Miami, Florida +2 locations
Conditions: Down Syndrome, Obstructive Sleep Apnea
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A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
NCT05702645
Recruiting
This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By learning more about the factors that may contribute to chronic health conditions and long-term effects after treatment for leukemia in persons with Down syndrome, clinical practice guidelines for survi... Read More
Gender:
ALL
Ages:
Between 6 years and 39 years
Trial Updated:
08/08/2025
Locations: Valley Children's Hospital, Madera, California +56 locations
Conditions: Down Syndrome, B Acute Lymphoblastic Leukemia Associated With Down Syndrome, Myeloid Leukemia Associated With Down Syndrome
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A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
NCT04546399
Recruiting
This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein that identifies and targets specific molecules in the body. Blinatumomab searches for and attaches itself to the cancer cell. Once attached, an immune response occu... Read More
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
07/01/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +207 locations
Conditions: Down Syndrome, Recurrent B Acute Lymphoblastic Leukemia
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Trial-Ready Cohort-Down Syndrome (TRC-DS)
NCT04165109
Recruiting
The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 450 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS) study. Participants enrolled in the TRC-DS will undergo longitudinal cognitive and clinical assessment, genetic and biomarker testing, as well as imaging and biospecimen collection. Using these outc... Read More
Gender:
ALL
Ages:
Between 25 years and 55 years
Trial Updated:
05/30/2025
Locations: Barrow Neurological Institute, Phoenix, Arizona +19 locations
Conditions: Down Syndrome, Alzheimer Disease, Dementia
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Brain Outcomes With Lifestyle Change in Down Syndrome
NCT05985486
Recruiting
The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease Adults with Down syndrome without dementia will be randomized to either a weight loss group or a general health education control group. The weight loss group will be asked to follow a reduced energy diet, attend monthly education sessions delivered remotely and self-monitor diet and body weight using commercially available we... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/15/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Down Syndrome, Alzheimer Disease, Obesity
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Measuring Aided Language Development
NCT06512168
Recruiting
The focus of the current study is to systematically investigate the psychometric properties of a range of aided language measures, which are based on the Graphic Symbol Utterance and Sentence Development Framework (Binger \& Kent-Walsh).
Gender:
ALL
Ages:
Between 42 months and 60 months
Trial Updated:
05/13/2025
Locations: University of Central Florida - Innovative Center, Orlando, Florida
Conditions: Down Syndrome, Cerebral Palsy, Apraxia of Speech, Speech Sound Disorder, Speech Disorders in Children, Speech and Language Disorder
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Harness-based Mobility Intervention for Infants With Down Syndrome
NCT06219863
Recruiting
The emergence of crawling and walking is significantly delayed in infants with Down syndrome (DS), but the development of independent mobility provides infants with new opportunities for exploring the environment and interacting with objects and people that are important foundations for early learning. Increasing infant mobility early in development with body weight supported harness systems may support infant exploration, communication, and social interaction. This project will set the stage fo... Read More
Gender:
ALL
Ages:
2 years and below
Trial Updated:
05/11/2025
Locations: Boston University, Boston, Massachusetts
Conditions: Down Syndrome
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Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)
NCT06673069
Recruiting
The primary purpose of this study is to evaluate the safety and tolerability of ION269 in adults with Down syndrome with evidence of brain amyloid positivity.
Gender:
ALL
Ages:
Between 35 years and 55 years
Trial Updated:
04/29/2025
Locations: Ionis Investigative Site, Indianapolis, Indiana +5 locations
Conditions: Alzheimer Disease, Down Syndrome
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How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome
NCT06951516
Recruiting
The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS). The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with DS (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplif... Read More
Gender:
ALL
Ages:
Between 2 years and 7 years
Trial Updated:
04/22/2025
Locations: Michigan State University, East Lansing, Michigan
Conditions: Down Syndrome
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Down Syndrome Obstructive Sleep Apnea
NCT06043440
Recruiting
The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
04/18/2025
Locations: Children's Hospital of Los Angeles, Los Angeles, California +6 locations
Conditions: Down Syndrome, Obstructive Sleep Apnea
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Patterns of Neurodevelopmental Disorders
NCT06213090
Recruiting
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
Gender:
ALL
Ages:
All
Trial Updated:
04/01/2025
Locations: Rossignol Medical Center, Phoenix, Arizona
Conditions: Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome, Down Syndrome, Epilepsy, Mitochondrial Encephalomyopathies, Cerebral Folate Deficiency
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Therapies for Down Syndrome Regression Disorder
NCT05662228
Recruiting
Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD). A DSRD diagnosis often includes a sub-acute onset of catatonia, mutism, depersonalization, loss of ability to perform activities of daily living, hallucinations, delusions, and aggression and is most commonly observed in adolescents and young adults. The study evaluates the safety and efficacy of three current... Read More
Gender:
ALL
Ages:
Between 8 years and 30 years
Trial Updated:
03/24/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +1 locations
Conditions: Down Syndrome, Regression
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