There are currently 11 active clinical trials seeking participants for Emphysema research studies. The states with the highest number of trials for Autism participants are California, Pennsylvania, Florida and Texas.
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
Recruiting
This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigators will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). The investigators will study the effect of pulmonary arterial vasodilation... Read More
Gender:
All
Ages:
Between 25 years and 65 years
Trial Updated:
03/27/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Emphysema
Smoking Cessation and Functional CT Assessment
Recruiting
The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema.
Gender:
All
Ages:
Between 21 years and 65 years
Trial Updated:
03/27/2024
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Emphysema
Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema
Recruiting
Phase 2 study to compare INBRX-101 to plasma derived A1PI therapy in adults with AATD emphysema
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/22/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +38 locations
Conditions: Alpha 1-Antitrypsin Deficiency, Emphysema
4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction Targeting
Recruiting
This study will investigate the utility of 4D Medical's X-ray Velocimetry (XV) imaging analysis software for the detection of hyperinflation, and compare endobronchial valve placement outcomes with predictive indices obtained utilizing this technique.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Copd, Emphysema, Hyperinflation
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
Recruiting
The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of ant... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
01/31/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +15 locations
Conditions: Emphysema, HIV
Anti-Platelets in Chronic Obstructive Pulmonary Disease
Recruiting
This is a 6 week crossover study in former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e. blood flow in the lungs measured on a contrast CT scan) compared to placebo.
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
12/08/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: COPD, Emphysema, Emphysema or COPD
Emphysema Research Registry and Biosample Repository
Recruiting
The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and therapeutic services. The Emphysema/COPD Research Center (ECRC) is a specialty clinic, within this center, that attempts to advance the understanding of emphysema and to evaluate new therapies for patients with emphysema. The Emphysema Research Registry will enable pulmonary research physicians to: 1)... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
11/10/2023
Locations: University of Pittsburgh Emphysema/COPD Research Center, Pittsburgh, Pennsylvania
Conditions: Emphysema, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
Recruiting
The purpose of this cross-sectional, observational study is to evaluate the site and mechanism(s) for expiratory airflow limitation in chronic, treated, current or former smokers (>15 pack years) with COPD, Emphysema, and Asthma-COPD Overlap with mild to severe expiratory airflow limitation. Treatment may include short and long acting inhaled beta2agonists, short and long acting inhaled muscarinic receptor antagonists, inhaled and or oral corticosteroid, oral antibiotic, supplemental oxygen, and... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
10/25/2023
Locations: Arthur F Gelb MD, Lakewood, California +1 locations
Conditions: COPD, Emphysema, Asthma COPD Overlap, Emphysema
STRIVE Post-Market Registry Study
Recruiting
This is a single-arm, prospective, multi-center, Registry study to evaluate the long-term safety and effectiveness of the Spiration Valve System (SVS) for the treatment of severe emphysema in a post-market setting.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/31/2023
Locations: El Camino, Taft Center for Clinical Research, Mountain View, California +7 locations
Conditions: Emphysema
Functional Lung Imaging in Patients With Respiratory Compromise Undergoing Endobronchial Valve Placement
Recruiting
Bronchoscopic lung volume reduction (BLVR) using endobronchial valves is effective in improving quality of life in patients suffering from emphysema. BLVR treatment in advanced emphysema requires targeted segmental or sub-segmental placement of endobronchial valves (EBV) to achieve total lobar occlusion to induce effective lobar volume reduction. BLVR procedure success rate declines in patients with incomplete lobar fissure integrity due to the potential for collateral ventilation to circumvent... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
10/20/2022
Locations: Temple University Hospital, Philadelphia, Pennsylvania
Conditions: Emphysema
COPD Patient-Powered Research Network
Recruiting
The COPD Patient-Powered Research Network (COPD PPRN) is a patient research registry with the goal of enrolling 75,000 or more COPD patients and those at risk who are willing to share their heath information over several years and participate in research. The COPD PPRN has built an online platform to allow volunteers to enroll electronically, complete surveys, be contacted about studies they qualify for and become connected to COPD resources. The goal of the registry is to speed research to find... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2022
Locations: COPD Foundation, Washington, District of Columbia
Conditions: Chronic Obstructive Pulmonary Disorder, Chronic Obstructive Lung Disease, Emphysema, Chronic Bronchitis